Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACSL5 Gene

Aliases for ACSL5 Gene

  • Acyl-CoA Synthetase Long-Chain Family Member 5 2 3
  • Long-Chain Acyl-CoA Synthetase 5 2 3 4
  • FACL5 3 4 6
  • ACS5 3 4 6
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 5 2 3
  • Long-Chain Fatty Acid Coenzyme A Ligase 5 2 3
  • FACL5 For Fatty Acid Coenzyme A Ligase 5 2 3
  • EC 6.2.1.3 4 64
  • LACS 5 3 4
  • Long-Chain-Fatty-Acid--CoA Ligase 5 3
  • Fatty Acid Coenzyme A Ligase 5 3
  • Fatty-Acid-Coenzyme A Ligase 2
  • Long-Chain 5 2
  • EC 6.2.1 64
  • ACS2 3

External Ids for ACSL5 Gene

Previous Symbols for ACSL5 Gene

  • FACL5

Summaries for ACSL5 Gene

Entrez Gene Summary for ACSL5 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACSL5 Gene

ACSL5 (Acyl-CoA Synthetase Long-Chain Family Member 5) is a Protein Coding gene. Diseases associated with ACSL5 include colorectal cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSBG2.

UniProtKB/Swiss-Prot for ACSL5 Gene

  • Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.

Gene Wiki entry for ACSL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL5 Gene

Genomics for ACSL5 Gene

Genomic Location for ACSL5 Gene

Start:
112,374,018 bp from pter
End:
112,428,380 bp from pter
Size:
54,363 bases
Orientation:
Plus strand

Genomic View for ACSL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL5 Gene

Regulatory Elements for ACSL5 Gene

Proteins for ACSL5 Gene

  • Protein details for ACSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC5-ACSL5_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 5
    Protein Accession:
    Q9ULC5
    Secondary Accessions:
    • A6GV77
    • D3DRB3
    • Q6UX44
    • Q9UIU4

    Protein attributes for ACSL5 Gene

    Size:
    683 amino acids
    Molecular mass:
    75991 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA85979.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86054.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSL5 Gene

Proteomics data for ACSL5 Gene at MOPED

Post-translational modifications for ACSL5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys404

Other Protein References for ACSL5 Gene

Domains for ACSL5 Gene

Gene Families for ACSL5 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSL5 Gene

UniProtKB/Swiss-Prot:

ACSL5_HUMAN
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.:
    • Q9ULC5
genes like me logo Genes that share domains with ACSL5: view

Function for ACSL5 Gene

Molecular function for ACSL5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.11 uM for palmitic acid (isoform 1 at pH 7.5) {ECO:0000269 PubMed:17681178}; KM=0.38 uM for palmitic acid (isoform 1 at pH 9.5) {ECO:0000269 PubMed:17681178}; KM=0.04 uM for palmitic acid (isoform 3 at pH 7.5) {ECO:0000269 PubMed:17681178}; KM=0.15 uM for palmitic acid (isoform 3 at pH 8.5) {ECO:0000269 PubMed:17681178}; pH dependence: Optimum pH is 9.5 (isoform 1), 7.5-8.5 (isoform 3). {ECO:0000269 PubMed:17681178};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
UniProtKB/Swiss-Prot Function: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.

Enzyme Numbers (IUBMB) for ACSL5 Gene

Gene Ontology (GO) - Molecular Function for ACSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACSL5: view

miRNA for ACSL5 Gene

miRTarBase miRNAs that target ACSL5

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACSL5 Gene

Localization for ACSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL5 Gene

Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSL5 Gene COMPARTMENTS Subcellular localization image for ACSL5 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
peroxisome 3
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for ACSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with ACSL5: view

Pathways for ACSL5 Gene

genes like me logo Genes that share pathways with ACSL5: view

Interacting Proteins for ACSL5 Gene

Gene Ontology (GO) - Biological Process for ACSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0008152 metabolic process --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with ACSL5: view

Compounds for ACSL5 Gene

(41) HMDB Compounds for ACSL5 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(5) Novoseek inferred chemical compound relationships for ACSL5 Gene

Compound -log(P) Hits PubMed IDs
1-aminocyclopropane-1-carboxylate 80.5 1
cytokinin 77.9 3
acyl-coa 76.3 5
ethylene 73.1 6
fatty acid 46.4 3
genes like me logo Genes that share compounds with ACSL5: view

Transcripts for ACSL5 Gene

Unigene Clusters for ACSL5 Gene

Acyl-CoA synthetase long-chain family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL5 Gene

No ASD Table

Relevant External Links for ACSL5 Gene

GeneLoc Exon Structure for
ACSL5
ECgene alternative splicing isoforms for
ACSL5

Expression for ACSL5 Gene

mRNA expression in normal human tissues for ACSL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACSL5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (7.7), Colon - Transverse (6.3), and Liver (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL5 Gene

SOURCE GeneReport for Unigene cluster for ACSL5 Gene Hs.11638

genes like me logo Genes that share expressions with ACSL5: view

Orthologs for ACSL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSL5 36
  • 99.41 (n)
  • 98.92 (a)
ACSL5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSL5 36
  • 85.8 (n)
  • 80.82 (a)
ACSL5 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSL5 36
  • 86.58 (n)
  • 83.75 (a)
ACSL5 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsl5 36
  • 83.21 (n)
  • 81.41 (a)
Acsl5 16
Acsl5 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSL5 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL5 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsl5 36
  • 82.33 (n)
  • 81.11 (a)
chicken
(Gallus gallus)
Aves ACSL5 36
  • 70.38 (n)
  • 69.4 (a)
ACSL5 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSL5 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl5 36
  • 65.98 (n)
  • 66.76 (a)
Str.11946 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4500 36
zebrafish
(Danio rerio)
Actinopterygii acsl5 36
  • 63.58 (n)
  • 66.81 (a)
acsl5 37
  • 67 (a)
OneToOne
wufa04h02 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011603 36
  • 53.72 (n)
  • 48.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3961 36
  • 54.73 (n)
  • 49.4 (a)
CG3961 37
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acs-13 36
  • 54.39 (n)
  • 49.38 (a)
acs-13 37
  • 45 (a)
ManyToMany
acs-5 37
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA2 37
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LACS6 36
  • 50.68 (n)
  • 46.56 (a)
corn
(Zea mays)
Liliopsida Zm.3042 36
rice
(Oryza sativa)
Liliopsida Os11g0147000 36
  • 51.29 (n)
  • 45.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
ManyToMany
CSA.10659 37
  • 49 (a)
ManyToMany
Species with no ortholog for ACSL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACSL5 Gene

ENSEMBL:
Gene Tree for ACSL5 (if available)
TreeFam:
Gene Tree for ACSL5 (if available)

Paralogs for ACSL5 Gene

Paralogs for ACSL5 Gene

Selected SIMAP similar genes for ACSL5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACSL5: view

Variants for ACSL5 Gene

Sequence variations from dbSNP and Humsavar for ACSL5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8624 -- 112,428,029(+) ACATA(C/T)TGTCC utr-variant-3-prime
rs876873 -- 112,411,841(+) CTCCA(C/T)TGGAA intron-variant
rs943260 -- 112,375,063(-) TATTT(A/C/T)TTTTT upstream-variant-2KB, intron-variant
rs1887138 -- 112,383,310(-) ATATT(A/T)ATTTT intron-variant
rs1926564 -- 112,380,138(-) AGTCA(C/T)AGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSL5 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv508609 CNV Loss 20534489
nsv7552 CNV Loss 18451855
nsv831990 CNV Loss 17160897
esv2740984 CNV Deletion 23290073
esv2740995 CNV Deletion 23290073
esv2741006 CNV Deletion 23290073
nsv512186 CNV Loss 21212237
esv2546876 CNV Deletion 19546169
esv2190783 CNV Deletion 18987734
esv4752 CNV Deletion 18987735
esv1472658 CNV Deletion 17803354
esv7592 CNV Loss 19470904
esv2741017 CNV Deletion 23290073
nsv831991 CNV Loss 17160897

Relevant External Links for ACSL5 Gene

HapMap Linkage Disequilibrium report
ACSL5
Human Gene Mutation Database (HGMD)
ACSL5

Disorders for ACSL5 Gene

(1) MalaCards Diseases for ACSL5 Gene

Search for ACSL5 Gene in MalaCards »

(3) Novoseek inferred disease relationships for ACSL5 Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma 39.3 8
adenoma 24.9 3
colorectal cancer 15.4 1

Relevant External Links for ACSL5

Genetic Association Database (GAD)
ACSL5
Human Genome Epidemiology (HuGE) Navigator
ACSL5
genes like me logo Genes that share disorders with ACSL5: view

No data available for UniProtKB/Swiss-Prot for ACSL5 Gene

Publications for ACSL5 Gene

  1. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. (PMID: 11127823) Yamashita Y. … Yamamoto T.T. (Oncogene 2000) 2 3 23
  2. Impaired expression of acyl-CoA-synthetase 5 in epithelial tumors of the small intestine. (PMID: 14608540) Gassler N. … Autschbach F. (Hum. Pathol. 2003) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5. (PMID: 15736044) Gassler N. … Autschbach F. (Histol. Histopathol. 2005) 3 23

Products for ACSL5 Gene

Sources for ACSL5 Gene

Back to Top

Content