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ACSL5 Gene

protein-coding   GIFtS: 61
GCID: GC10P114123

Acyl-CoA Synthetase Long-Chain Family Member 5

(Previous names: fatty-acid-Coenzyme A ligase, long-chain 5)
(Previous symbol: FACL5)
  See ACSL5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Synthetase Long-Chain Family Member 51 2     EC 6.2.1.33 8
FACL51 2 3 5     Fatty-Acid-Coenzyme A Ligase1
Long-Chain Acyl-CoA Synthetase 51 2 3     Long-Chain 51
ACS52 3 5     ACS22
Fatty-Acid-Coenzyme A Ligase, Long-Chain 51 2     Fatty Acid Coenzyme A Ligase 52
FACL5 For Fatty Acid Coenzyme A Ligase 51 2     Long-Chain-Fatty-Acid--CoA Ligase 52
Long-Chain Fatty Acid Coenzyme A Ligase 51 2     EC 6.2.18
LACS 52 3     

External Ids:    HGNC: 165261   Entrez Gene: 517032   Ensembl: ENSG000001971427   OMIM: 6056775   UniProtKB: Q9ULC53   

Export aliases for ACSL5 gene to outside databases

Previous GC identifers: GC10P113800 GC10P107761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACSL5 Gene:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although
differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this
family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid
biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace
amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating
fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACSL5 Gene:
ACSL5 (acyl-CoA synthetase long-chain family member 5) is a protein-coding gene. Diseases associated with ACSL5 include colorectal cancer. GO annotations related to this gene include long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSBG1.

UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5
Function: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and
degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of
triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty
acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also
stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine
may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in
the survival of glioma cells

Gene Wiki entry for ACSL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACSL5 gene promoter:
         Sox5   p300   STAT5A   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ACSL5 promoter sequence
   Search Chromatin IP Primers for ACSL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACSL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1-q25.2   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q25.1-q25.2

ACSL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSL5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P114123:  view genomic region     (about GC identifiers)

Start:
114,133,776 bp from pter      End:
114,188,138 bp from pter
Size:
54,363 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5 (See protein sequence)
Recommended Name: Long-chain-fatty-acid--CoA ligase 5  
Size: 683 amino acids; 75991 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=BAA85979.1; Type=Erroneous initiation; Sequence=BAA86054.1; Type=Erroneous gene model
prediction;
Secondary accessions: D3DRB3 Q6UX44 Q9UIU4
Alternative splicing: 3 isoforms:  Q9ULC5-1   Q9ULC5-3   Q9ULC5-4   (Localize in mitochondrion and endoplasmic reticulum)

Explore the universe of human proteins at neXtProt for ACSL5: NX_Q9ULC5

Explore proteomics data for ACSL5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys404
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACSL5 (Q9ULC5) (see all 11)
     RKPNQPY  YGQTECT  LPLAHMFE  VPLYDTLG 


    See ACSL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_057318.2  NP_976313.1  NP_976314.1  

    ENSEMBL proteins: 
     ENSP00000346680   ENSP00000346223   ENSP00000348429   ENSP00000376796   ENSP00000403647  
     ENSP00000358418  
    Reactome Protein details: Q9ULC5

    ACSL5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ACSL5
    OriGene Protein Over-expression Lysate for ACSL5
    OriGene MassSpec for ACSL5
    OriGene Custom Protein Services for ACSL5
    GenScript Custom Purified and Recombinant Proteins Services for ACSL5
    Novus Biologicals ACSL5 Proteins
    Novus Biologicals ACSL5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACSL5

     
    Search eBioscience for Proteins for ACSL5 

     
    antibodies-online proteins for ACSL5 (7 products) 

     
    antibodies-online peptides for ACSL5

    ACSL5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals ACSL5 Antibodies
    Abcam antibodies for ACSL5
    Cloud-Clone Corp. Antibodies for ACSL5
    ThermoFisher Antibody for ACSL5
    LSBio Antibodies in human, mouse, rat for ACSL5
    antibodies-online antibodies for ACSL5 (26 products) 

    ACSL5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACSL5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACSL5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACSL5
    Cloud-Clone Corp. CLIAs for ACSL5
    Search eBioscience for ELISAs for ACSL5 
    antibodies-online kits for ACSL5 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACS: Acyl-CoA synthetase family

    2 InterPro protein domains:
     IPR020845 AMP-binding_CS
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry Q9ULC5

    ProtoNet protein and cluster: Q9ULC5

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Find genes that share domains with ACSL5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACSL5_HUMAN, Q9ULC5
    Function: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and
    degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of
    triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty
    acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also
    stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine
    may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in
    the survival of glioma cells
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
    Biophysicochemical properties: Kinetic parameters: KM=0.11 uM for palmitic acid (isoform 1 at pH 7.5); KM=0.38 uM
    for palmitic acid (isoform 1 at pH 9.5); KM=0.04 uM for palmitic acid (isoform 3 at pH 7.5); KM=0.15 uM for
    palmitic acid (isoform 3 at pH 8.5); pH dependence: Optimum pH is 9.5 (isoform 1), 7.5-8.5 (isoform 3);

         Enzyme Numbers (IUBMB): EC 6.2.1.31 2 EC 6.2.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016874ligase activity ----
         
    Find genes that share ontologies with ACSL5           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Acsl5 (no phenotypes)

    Find genes that share phenotypes with ACSL5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACSL5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACSL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACSL5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACSL5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACSL5:
    hsa-mir-128-3p (MIRT022047), hsa-mir-124-3p (MIRT023184), hsa-mir-335-5p (MIRT019161)

    Block miRNA regulation of human, mouse, rat ACSL5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACSL5 (see all 10):
    hsa-miR-875-3p hsa-miR-218-1* hsa-miR-4267 hsa-miR-548g hsa-miR-3654 hsa-miR-2115 hsa-miR-1243 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmidACSL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACSL5
    Predesigned siRNA for gene silencing in human, mouse, rat ACSL5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACSL5

    Clone
    Products:
         
    OriGene clones in human, mouse for ACSL5 (see all 17)
    OriGene ORF clones in mouse, rat for ACSL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ACSL5 (NM_203379)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACSL5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACSL5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACSL5_HUMAN, Q9ULC5: Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III
    membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    peroxisome3
    plasma membrane3
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005743mitochondrial inner membrane IEA--

    Find genes that share ontologies with ACSL5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACSL5 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    2PPAR signaling pathway
    fatty acid beta-oxidation VI (peroxisome)0.00
    PPAR signaling pathway
    3stearate biosynthesis I (animals)
    stearate biosynthesis I (animals)0.35
    eicosapentaenoate biosynthesis II (metazoa)0.00
    gamma-linolenate biosynthesis II (animals)0.35
    fatty acid activation0.00
    fatty acid beta-oxidation I0.30
    4Triglyceride Biosynthesis
    Triglyceride Biosynthesis
    Fatty Acyl-CoA Biosynthesis0.00
    Synthesis of very long-chain fatty acyl-CoAs0.00
    5Fatty acid metabolism
    Fatty acid metabolism0.42
    Fatty acid degradation0.42


    Find genes that share SuperPaths with ACSL5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for ACSL5 (see all 8)
        Fatty Acid Beta Oxidation
    stearate biosynthesis I (animals)
    gamma-linolenate biosynthesis II (animals)
    fatty acid beta-oxidation VI (peroxisome)
    fatty acid beta-oxidation I

    1 Reactome Pathway for ACSL5
        Synthesis of very long-chain fatty acyl-CoAs


    Selected Kegg Pathways  (Kegg details for ACSL5) (see all 6):
        Fatty acid degradation
    Metabolic pathways
    Fatty acid metabolism
    PPAR signaling pathway
    Peroxisome

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACSL5: 
              Fatty Acid Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Fatty Liver in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ACSL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACSL5 (Q9ULC53 ENSP000003484294) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    ACADLENSP000002337104STRING: ENSP00000233710
    ACADMENSP000004096124STRING: ENSP00000409612
    ACADVLENSP000003253954STRING: ENSP00000325395
    ACOX1ENSP000002932174STRING: ENSP00000293217
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001676long-chain fatty acid metabolic process IDA17681178
    GO:0008152metabolic process ----
    GO:0019432triglyceride biosynthetic process TAS--
    GO:0035338long-chain fatty-acyl-CoA biosynthetic process TAS--
    GO:0044255cellular lipid metabolic process TAS--

    Find genes that share ontologies with ACSL5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACSL5

    Selected HMDB Compounds for ACSL5 (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----

    5 Novoseek inferred chemical compound relationships for ACSL5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-aminocyclopropane-1-carboxylate 80.5 1 9539813 (1)
    cytokinin 77.9 10 9539813 (1), 15118728 (1), 18980656 (1)
    acyl-coa 76.3 5 15051725 (1), 15736044 (1), 16241998 (1), 15885896 (1) (see all 5)
    ethylene 73.1 9 9539813 (3), 15118728 (2), 18808454 (1)
    fatty acid 46.4 4 15051725 (1), 11127823 (1), 16241998 (1)



    Find genes that share compounds with ACSL5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACSL5 gene (3 alternative transcripts): 
    NM_016234.3  NM_203379.1  NM_203380.1  

    Unigene Cluster for ACSL5:

    Acyl-CoA synthetase long-chain family member 5
    Hs.11638  [show with all ESTs]
    Unigene Representative Sequence: NM_203380
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354655(uc001kzs.3) ENST00000479936 ENST00000354273(uc009xxz.3 uc010qrj.2)
    ENST00000495539 ENST00000467340 ENST00000496328 ENST00000356116(uc001kzu.3)
    ENST00000393081(uc001kzt.3) ENST00000433418 ENST00000369410
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACSL5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACSL5 (see all 10):
    hsa-miR-875-3p hsa-miR-218-1* hsa-miR-4267 hsa-miR-548g hsa-miR-3654 hsa-miR-2115 hsa-miR-1243 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmidACSL5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACSL5
    Predesigned siRNA for gene silencing in human, mouse, rat ACSL5
    Clone
    Products:
         
    OriGene clones in human, mouse for ACSL5 (see all 17)
    OriGene ORF clones in mouse, rat for ACSL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ACSL5 (NM_203379)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACSL5
    OriGene qSTAR qPCR primer pairs in human, mouse for ACSL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACSL5
      QuantiTect SYBR Green Assays in human, mouse, rat ACSL5
      QuantiFast Probe-based Assays in human, mouse, rat ACSL5

    Additional mRNA sequence: 

    AB033899.1 AJ496489.1 AK000339.1 AK024932.1 AK222782.1 AK223288.1 AK301786.1 AK310436.1 
    AM262166.1 AY358520.1 BC007985.2 

    13 DOTS entries:

    DT.445254  DT.99927408  DT.75109374  DT.121284808  DT.95298959  DT.100781967  DT.100804348  DT.92427826 
    DT.95347878  DT.97812641  DT.97855857  DT.91683457  DT.92427832 

    Selected AceView cDNA sequences (see all 226):

    BQ229959 AW082938 CB161735 AI309579 AI619909 BU619634 BM855568 BU629075 
    AI569416 BQ690117 BG754711 AY358520 T81194 AI365079 CD370136 BC007985 
    AI870460 AI760607 NM_203380 BU608372 BM764896 BU626754 AI677664 AL708724 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACSL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTCTAC
    ACSL5 Expression
    About this image


    ACSL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Perivascular Adipose
             White adipocyte-like cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Thymus (Hematopoietic System)
             Thymus
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Kidney (Urinary System)
             Metanephros
    ACSL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACSL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11638
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACSL5: 
              Fatty Acid Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Fatty Liver in human mouse rat
              PPAR Targets in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACSL5 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acsl51 , 5 acyl-CoA synthetase long-chain family member 51, 5 83.21(n)1
    81.41(a)1
      19 (51.30 cM)5
    4332561  NM_027976.21  NP_082252.11 
     552533695 
    chicken
    (Gallus gallus)
    Aves ACSL51 acyl-CoA synthetase long-chain family member 5 70.38(n)
    69.4(a)
      423896  NM_001031237.1  NP_001026408.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACSL56
    acyl-CoA synthetase long-chain family member 5
    68(a)
    1 ↔ 1
    GL343204.1(1964896-1987009)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119462 Transcribed sequence with moderate similarity to protein more 72.38(n)    BX727325.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa04h022 wufa04h02 76.7(n)   334836  AA497359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39611 CG3961 54.73(n)
    49.4(a)
      40056  NM_168781.3  NP_730369.1 
    worm
    (Caenorhabditis elegans)
    Secernentea acs-131 acs-13 54.39(n)
    49.38(a)
      171643  NM_058343.3  NP_490744.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAA26
    Medium chain fatty acyl-CoA synthetase, activates ...
    30(a)
    1 → many
    V(184541-186775) YER015W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LACS61 LACS6 50.68(n)
    46.56(a)
      819767  NM_111471.2  NP_566265.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g01470001 Os11g0147000 51.29(n)
    45.26(a)
      4349764  NM_001072271.1  NP_001065739.1 


    ENSEMBL Gene Tree for ACSL5 (if available)
    TreeFam Gene Tree for ACSL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACSL5 gene
    ACSBG12  ACSL62  ACSBG22  ACSL12  
    6 SIMAP similar genes for ACSL5 using alignment to 2 protein entries:     ACSL5_HUMAN (see all proteins):
    FACL5    ACSL6    ACSL1    ACSL3    ACSL4    FACL4

    Find genes that share paralogs with ACSL5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACSL5 (see all 1188)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363784
    A colorectal cancer sample4--see VAR_0363782 G D mis40--------
    VAR_0363774
    A colorectal cancer sample4--see VAR_0363772 K R mis40--------
    rs1905425631,2
    --114131925(+) GTGGGA/GACATG 1 -- us2k10--------
    rs1388260751,2
    --114132043(+) ACGGAA/CCAATC 1 -- us2k10--------
    rs1419108811,2
    --114132091(+) ATGGAC/TCAATC 1 -- us2k10--------
    rs1463973311,2
    --114132143(+) CTGTCC/TGAGCC 1 -- us2k10--------
    rs1420078511,2
    --114132197(+) TTGTTC/GTTTAG 1 -- us2k10--------
    rs1817337121,2
    --114132225(+) TGCTAC/TTGCTC 1 -- us2k10--------
    rs1506744401,2
    --114132246(+) TCTACA/GCTGCT 1 -- us2k10--------
    rs1873734671,2
    --114132256(+) TTTTAC/TGAGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACSL5 (114133776 - 114188138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ACSL5 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2190783CNV Deletion18987734
    esv2740995CNV Deletion23290073
    esv1472658CNV Deletion17803354
    esv2741017CNV Deletion23290073
    esv2740984CNV Deletion23290073
    esv2741006CNV Deletion23290073
    esv4752CNV Deletion18987735
    esv2546876CNV Deletion19546169
    esv7592CNV Loss19470904
    nsv508609CNV Loss20534489

    Human Gene Mutation Database (HGMD): ACSL5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACSL5
    DNA2.0 Custom Variant and Variant Library Synthesis for ACSL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605677    OMIM disorders: --

    1 disease for ACSL5:    
    About MalaCards
    colorectal cancer


    Find genes that share disorders with ACSL5           About GenesLikeMe

    3 Novoseek inferred disease relationships for ACSL5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 39.3 11 16110457 (4), 16241998 (3), 14608540 (1)
    adenoma 24.9 4 16110457 (2), 14608540 (1)
    colorectal cancer 15.4 1 16110457 (1)

    Genetic Association Database (GAD): ACSL5
    Human Genome Epidemiology (HuGE) Navigator: ACSL5 (5 documents)

    Export disorders for ACSL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACSL5 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with ACSL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. (PubMed id 11127823)1, 3, 9 Yamashita Y....Yamamoto T.T. (Oncogene 2000)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions. (PubMed id 18806831)1, 2 Mashima T.... Seimiya H. (Oncogene 2009)
    5. Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. (PubMed id 17495181)1, 4 Adamo K.B....Tesson F. (Obesity (Silver Spring) 2007)
    6. Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. (PubMed id 17681178)1, 2 Gassler N.... Kopitz J. (Gastroenterology 2007)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51703 HGNC: 16526 AceView: ACSL5 Ensembl:ENSG00000197142 euGenes: HUgn51703
    ECgene: ACSL5 Kegg: 51703 H-InvDB: ACSL5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACSL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACSL5 gene:
    Search GeneIP for patents involving ACSL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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