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Aliases for ACSL5 Gene

Aliases for ACSL5 Gene

  • Acyl-CoA Synthetase Long-Chain Family Member 5 2 3 5
  • Long-Chain Acyl-CoA Synthetase 5 2 3 4
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 5 2 3
  • Long-Chain Fatty Acid Coenzyme A Ligase 5 2 3
  • FACL5 For Fatty Acid Coenzyme A Ligase 5 2 3
  • EC 6.2.1.3 4 63
  • LACS 5 3 4
  • FACL5 3 4
  • ACS5 3 4
  • Fatty Acid Coenzyme A Ligase 5 3
  • Fatty-Acid-Coenzyme A Ligase 2
  • Long-Chain 5 2
  • EC 6.2.1 63
  • ACS2 3

External Ids for ACSL5 Gene

Previous HGNC Symbols for ACSL5 Gene

  • FACL5

Previous GeneCards Identifiers for ACSL5 Gene

  • GC10P113800
  • GC10P114123
  • GC10P107761

Summaries for ACSL5 Gene

Entrez Gene Summary for ACSL5 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACSL5 Gene

ACSL5 (Acyl-CoA Synthetase Long-Chain Family Member 5) is a Protein Coding gene. Diseases associated with ACSL5 include chronic intestinal vascular insufficiency and glioma. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSBG2.

UniProtKB/Swiss-Prot for ACSL5 Gene

  • Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.

Gene Wiki entry for ACSL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL5 Gene

Genomics for ACSL5 Gene

Regulatory Elements for ACSL5 Gene

Promoters for ACSL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACSL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACSL5 Gene

Chromosome:
10
Start:
112,374,018 bp from pter
End:
112,428,380 bp from pter
Size:
54,363 bases
Orientation:
Plus strand

Genomic View for ACSL5 Gene

Genes around ACSL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL5 Gene

Proteins for ACSL5 Gene

  • Protein details for ACSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC5-ACSL5_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 5
    Protein Accession:
    Q9ULC5
    Secondary Accessions:
    • A6GV77
    • D3DRB3
    • Q6UX44
    • Q9UIU4

    Protein attributes for ACSL5 Gene

    Size:
    683 amino acids
    Molecular mass:
    75991 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA85979.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86054.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSL5 Gene

Proteomics data for ACSL5 Gene at MOPED

Post-translational modifications for ACSL5 Gene

  • Ubiquitination at Lys 404
  • Modification sites at PhosphoSitePlus

Other Protein References for ACSL5 Gene

Antibody Products

Domains & Families for ACSL5 Gene

Gene Families for ACSL5 Gene

Protein Domains for ACSL5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULC5

UniProtKB/Swiss-Prot:

ACSL5_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSL5: view

Function for ACSL5 Gene

Molecular function for ACSL5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.11 uM for palmitic acid (isoform 1 at pH 7.5) {ECO:0000269 PubMed:17681178}; KM=0.38 uM for palmitic acid (isoform 1 at pH 9.5) {ECO:0000269 PubMed:17681178}; KM=0.04 uM for palmitic acid (isoform 3 at pH 7.5) {ECO:0000269 PubMed:17681178}; KM=0.15 uM for palmitic acid (isoform 3 at pH 8.5) {ECO:0000269 PubMed:17681178}; pH dependence: Optimum pH is 9.5 (isoform 1), 7.5-8.5 (isoform 3). {ECO:0000269 PubMed:17681178};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
UniProtKB/Swiss-Prot Function:
Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.

Enzyme Numbers (IUBMB) for ACSL5 Gene

genes like me logo Genes that share phenotypes with ACSL5: view

Animal Models for ACSL5 Gene

MGI Knock Outs for ACSL5:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACSL5 Gene

Localization for ACSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL5 Gene

Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSL5 Gene COMPARTMENTS Subcellular localization image for ACSL5 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
peroxisome 3
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for ACSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ACSL5: view

Pathways & Interactions for ACSL5 Gene

genes like me logo Genes that share pathways with ACSL5: view

Interacting Proteins for ACSL5 Gene

Gene Ontology (GO) - Biological Process for ACSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019432 triglyceride biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with ACSL5: view

No data available for SIGNOR curated interactions for ACSL5 Gene

Drugs & Compounds for ACSL5 Gene

(8) Drugs for ACSL5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Propionyl-CoA Experimental Pharma 0

(37) Additional Compounds for ACSL5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSL5: view

Transcripts for ACSL5 Gene

Unigene Clusters for ACSL5 Gene

Acyl-CoA synthetase long-chain family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL5 Gene

No ASD Table

Relevant External Links for ACSL5 Gene

GeneLoc Exon Structure for
ACSL5
ECgene alternative splicing isoforms for
ACSL5

Expression for ACSL5 Gene

mRNA expression in normal human tissues for ACSL5 Gene

mRNA differential expression in normal tissues according to GTEx for ACSL5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x7.7), Colon - Transverse (x6.3), and Liver (x5.2).

Protein differential expression in normal tissues from HIPED for ACSL5 Gene

This gene is overexpressed in Breast (32.3), Nasal epithelium (8.9), and Gallbladder (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL5 Gene



SOURCE GeneReport for Unigene cluster for ACSL5 Gene Hs.11638

genes like me logo Genes that share expression patterns with ACSL5: view

Protein tissue co-expression partners for ACSL5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ACSL5 Gene

Orthologs for ACSL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACSL5 35
  • 85.8 (n)
  • 80.82 (a)
ACSL5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSL5 35
  • 86.58 (n)
  • 83.75 (a)
ACSL5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsl5 35
  • 83.21 (n)
  • 81.41 (a)
Acsl5 16
Acsl5 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACSL5 35
  • 99.41 (n)
  • 98.92 (a)
ACSL5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsl5 35
  • 82.33 (n)
  • 81.11 (a)
oppossum
(Monodelphis domestica)
Mammalia ACSL5 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL5 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACSL5 35
  • 70.38 (n)
  • 69.4 (a)
ACSL5 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSL5 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl5 35
  • 65.98 (n)
  • 66.76 (a)
Str.11946 35
zebrafish
(Danio rerio)
Actinopterygii acsl5 35
  • 63.58 (n)
  • 66.81 (a)
wufa04h02 35
acsl5 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4500 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011603 35
  • 53.72 (n)
  • 48.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3961 35
  • 54.73 (n)
  • 49.4 (a)
CG3961 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acs-13 35
  • 54.39 (n)
  • 49.38 (a)
acs-13 36
  • 45 (a)
ManyToMany
acs-5 36
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA2 36
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LACS6 35
  • 50.68 (n)
  • 46.56 (a)
rice
(Oryza sativa)
Liliopsida Os11g0147000 35
  • 51.29 (n)
  • 45.26 (a)
corn
(Zea mays)
Liliopsida Zm.3042 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
ManyToMany
CSA.10659 36
  • 49 (a)
ManyToMany
Species with no ortholog for ACSL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACSL5 Gene

ENSEMBL:
Gene Tree for ACSL5 (if available)
TreeFam:
Gene Tree for ACSL5 (if available)

Paralogs for ACSL5 Gene

Paralogs for ACSL5 Gene

(6) SIMAP similar genes for ACSL5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACSL5: view

Variants for ACSL5 Gene

Sequence variations from dbSNP and Humsavar for ACSL5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3736946 - 112,409,518(-) CACCA(C/T)GGCGA reference, missense
VAR_036377 A colorectal cancer sample
VAR_036378 A colorectal cancer sample
rs12254915 - 112,422,015(+) ACTTT(A/G)CAGTG reference, missense
rs943260 -- 112,375,063(-) TATTT(A/C/T)TTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ACSL5 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv508609 CNV Loss 20534489
nsv7552 CNV Loss 18451855
nsv831990 CNV Loss 17160897
esv2740984 CNV Deletion 23290073
esv2740995 CNV Deletion 23290073
esv2741006 CNV Deletion 23290073
nsv512186 CNV Loss 21212237
esv2546876 CNV Deletion 19546169
esv2190783 CNV Deletion 18987734
esv4752 CNV Deletion 18987735
esv1472658 CNV Deletion 17803354
esv7592 CNV Loss 19470904
esv2741017 CNV Deletion 23290073
nsv831991 CNV Loss 17160897

Variation tolerance for ACSL5 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACSL5 Gene

HapMap Linkage Disequilibrium report
ACSL5
Human Gene Mutation Database (HGMD)
ACSL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL5 Gene

Disorders for ACSL5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ACSL5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
glioma
- elite association - COSMIC cancer census association via MalaCards
Search ACSL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACSL5

Genetic Association Database (GAD)
ACSL5
Human Genome Epidemiology (HuGE) Navigator
ACSL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACSL5
genes like me logo Genes that share disorders with ACSL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACSL5 Gene

Publications for ACSL5 Gene

  1. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. (PMID: 11127823) Yamashita Y. … Yamamoto T.T. (Oncogene 2000) 2 3 23 67
  2. Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5. (PMID: 15809837) ObermA1ller N. … Gassler N. (Int J Colorectal Dis 2006) 3 23
  3. Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5. (PMID: 15736044) Gassler N. … Autschbach F. (Histol. Histopathol. 2005) 3 23
  4. Impaired expression of acyl-CoA-synthetase 5 in epithelial tumors of the small intestine. (PMID: 14608540) Gassler N. … Autschbach F. (Hum. Pathol. 2003) 3 23
  5. TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas. (PMID: 24770931) Klaus C. … Gassler N. (Cell Tissue Res. 2014) 3

Products for ACSL5 Gene

Sources for ACSL5 Gene

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