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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACSL5 Gene

protein-coding   GIFtS: 60
GCID: GC10P114123

Acyl-CoA Synthetase Long-Chain Family Member 5

(Previous names: fatty-acid-Coenzyme A ligase, long-chain 5)
(Previous symbol: FACL5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acyl-CoA Synthetase Long-Chain Family Member 51 2     EC 6.2.1.33 8
FACL51 2 3 5     Fatty-Acid-Coenzyme A Ligase1
Long-Chain Acyl-CoA Synthetase 51 2 3     Long-Chain 51
ACS52 3 5     ACS22
Fatty-Acid-Coenzyme A Ligase, Long-Chain 51 2     Fatty Acid Coenzyme A Ligase 52
FACL5 For Fatty Acid Coenzyme A Ligase 51 2     Long-Chain-Fatty-Acid--CoA Ligase 52
Long-Chain Fatty Acid Coenzyme A Ligase 51 2     EC 6.2.18
LACS 52 3     

External Ids:    HGNC: 165261   Entrez Gene: 517032   Ensembl: ENSG000001971427   OMIM: 6056775   UniProtKB: Q9ULC53   

Export aliases for ACSL5 gene to outside databases

Previous GC identifers: GC10P113800 GC10P107761


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACSL5 Gene:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although
differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this
family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid
biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace
amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating
fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACSL5 Gene: 
ACSL5 (acyl-CoA synthetase long-chain family member 5) is a protein-coding gene. Diseases associated with ACSL5 include malignant glioma, and hypertriglyceridemia, and among its related super-pathways are Metabolic pathways and Fatty Acid Beta Oxidation. GO annotations related to this gene include long-chain fatty acid-CoA ligase activity and ATP binding. An important paralog of this gene is ACSBG1.

UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5
Function: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and
degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of
triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty
acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also
stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine
may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in
the survival of glioma cells

Gene Wiki entry for ACSL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACSL5 gene promoter:
         Sox5   p300   STAT5A   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ACSL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACSL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1-q25.2   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q25.1-q25.2

ACSL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSL5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P114123:  view genomic region     (about GC identifiers)

Start:
114,133,776 bp from pter      End:
114,188,138 bp from pter
Size:
54,363 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5 (See protein sequence)
Recommended Name: Long-chain-fatty-acid--CoA ligase 5  
Size: 683 amino acids; 75991 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III
membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By
similarity)
Sequence caution: Sequence=BAA85979.1; Type=Erroneous initiation; Sequence=BAA86054.1; Type=Erroneous gene model
prediction;
Secondary accessions: D3DRB3 Q6UX44 Q9UIU4
Alternative splicing: 3 isoforms:  Q9ULC5-1   Q9ULC5-3   Q9ULC5-4   (Localize in mitochondrion and endoplasmic reticulum)

Explore the universe of human proteins at neXtProt for ACSL5: NX_Q9ULC5

Explore proteomics data for ACSL5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULC5

  • 4/11 DME Specific Peptides for ACSL5 (Q9ULC5) (see all 11)
     RKPNQPY  YGQTECT  LPLAHMFE  VPLYDTLG 

    ACSL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACSL5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_057318.2  NP_976313.1  NP_976314.1  

    ENSEMBL proteins: 
     ENSP00000346680   ENSP00000346223   ENSP00000348429   ENSP00000376796   ENSP00000403647  
     ENSP00000358418  
    Reactome Protein details: Q9ULC5
    Human Recombinant Protein Products for ACSL5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for ACSL5
    OriGene Protein Over-expression Lysate for ACSL5
    OriGene MassSpec for ACSL5 
    OriGene Custom Protein Services for ACSL5
    GenScript Custom Purified and Recombinant Proteins Services for ACSL5
    Novus Biologicals ACSL5 Proteins
    Novus Biologicals ACSL5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACSL5 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA17681178
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005783endoplasmic reticulum IDA17681178
    GO:0005789endoplasmic reticulum membrane TAS--

    ACSL5 for ontologies           About GeneDecksing



    ACSL5 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ACSL5 
    Cloud-Clone Corp. CLIAs for ACSL5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ACS: Acyl-CoA synthetase family

    2 InterPro protein domains:
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry Q9ULC5

    ProtoNet protein and cluster: Q9ULC5

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    ACSL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACSL5_HUMAN, Q9ULC5
    Function: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and
    degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of
    triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty
    acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also
    stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine
    may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in
    the survival of glioma cells
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
    Biophysicochemical properties: Kinetic parameters: KM=0.11 uM for palmitic acid (isoform 1 at pH 7.5); KM=0.38 uM
    for palmitic acid (isoform 1 at pH 9.5); KM=0.04 uM for palmitic acid (isoform 3 at pH 7.5); KM=0.15 uM for
    palmitic acid (isoform 3 at pH 8.5); pH dependence: Optimum pH is 9.5 (isoform 1), 7.5-8.5 (isoform 3);

         Enzyme Numbers (IUBMB): EC 6.2.1.31 2 EC 6.2.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016874ligase activity ----
         
    ACSL5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Acsl5 (no phenotypes)

    ACSL5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Acsl5tm1Lex for ACSL5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACSL5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACSL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACSL5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACSL5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSL5
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSL5 (see all 10):
    hsa-miR-875-3p hsa-miR-218-1* hsa-miR-4267 hsa-miR-548g hsa-miR-3654 hsa-miR-2115 hsa-miR-1243 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmidACSL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACSL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSL5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACSL5
    Sirion Biotech Customized adenovirus for overexpression of ACSL5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ACSL5 (see all 17)
    OriGene ORF clones in mouse, rat for ACSL5
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    GenScript: all cDNA clones in your preferred vector (see all 3): ACSL5 (NM_203379)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL5
    Sirion Biotech Customized lentivirus for stable overexpression of ACSL5 
                         Customized lentivirus expression plasmids for stable overexpression of ACSL5 

    Cell Line
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    Search LifeMap BioReagents cell lines for ACSL5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACSL5 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    2Fatty Acid Beta Oxidation
    Fatty Acid Beta Oxidation0.35
    Fatty acid degradation0.32
    3fatty acid activation
    fatty acid activation0.55
    fatty acid beta-oxidation VI (peroxisome)0.46
    stearate biosynthesis I (animals)0.55
    fatty acid beta-oxidation I0.40
    4Fatty Acyl-CoA Biosynthesis
    Fatty Acyl-CoA Biosynthesis0.78
    Triglyceride Biosynthesis0.47
    Synthesis of very long-chain fatty acyl-CoAs0.78
    5eicosapentaenoate biosynthesis II (metazoa)
    gamma-linolenate biosynthesis II (animals)0.69
    eicosapentaenoate biosynthesis II (metazoa)0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8 BioSystems Pathways for ACSL5 (see all 8)
        Fatty Acid Beta Oxidation
    stearate biosynthesis I (animals)
    gamma-linolenate biosynthesis II (animals)
    fatty acid beta-oxidation VI (peroxisome)
    fatty acid beta-oxidation I

    5/6        Reactome Pathways for ACSL5 (see all 6)
        Metabolism
    Synthesis of very long-chain fatty acyl-CoAs
    Triglyceride Biosynthesis
    Fatty Acyl-CoA Biosynthesis
    Fatty acid, triacylglycerol, and ketone body metabolism


    5         Kegg Pathways  (Kegg details for ACSL5):
        Fatty acid degradation
    Metabolic pathways
    PPAR signaling pathway
    Peroxisome
    Adipocytokine signaling pathway


    ACSL5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACSL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/25 Interacting proteins for ACSL5 (Q9ULC53 ENSP000003484294) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    ACADLENSP000002337104STRING: ENSP00000233710
    ACADMENSP000004096124STRING: ENSP00000409612
    ACADVLENSP000003253954STRING: ENSP00000325395
    ACOX1ENSP000002932174STRING: ENSP00000293217
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001676long-chain fatty acid metabolic process IDA17681178
    GO:0008152metabolic process ----
    GO:0019432triglyceride biosynthetic process TAS--
    GO:0035338long-chain fatty-acyl-CoA biosynthetic process TAS--
    GO:0044255cellular lipid metabolic process TAS--

    ACSL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACSL5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACSL5

    10/41 HMDB Compounds for ACSL5 (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----

    5 Novoseek inferred chemical compound relationships for ACSL5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-aminocyclopropane-1-carboxylate 80.5 1 9539813 (1)
    cytokinin 77.9 10 9539813 (1), 15118728 (1), 18980656 (1)
    acyl-coa 76.3 5 15051725 (1), 15736044 (1), 16241998 (1), 15885896 (1) (see all 5)
    ethylene 73.1 9 9539813 (3), 15118728 (2), 18808454 (1)
    fatty acid 46.4 4 15051725 (1), 11127823 (1), 16241998 (1)

    Search CenterWatch for drugs/clinical trials and news about ACSL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACSL5 gene (3 alternative transcripts): 
    NM_016234.3  NM_203379.1  NM_203380.1  

    Unigene Cluster for ACSL5:

    Acyl-CoA synthetase long-chain family member 5
    Hs.11638  [show with all ESTs]
    Unigene Representative Sequence: NM_203380
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354655(uc001kzs.3) ENST00000479936 ENST00000354273(uc009xxz.3 uc010qrj.2)
    ENST00000495539 ENST00000467340 ENST00000496328 ENST00000356116(uc001kzu.3)
    ENST00000393081(uc001kzt.3) ENST00000433418 ENST00000369410

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSL5 (see all 10):
    hsa-miR-875-3p hsa-miR-218-1* hsa-miR-4267 hsa-miR-548g hsa-miR-3654 hsa-miR-2115 hsa-miR-1243 hsa-miR-375
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    GenScript: all cDNA clones in your preferred vector (see all 3): ACSL5 (NM_203379)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL5
    Sirion Biotech Customized lentivirus for stable overexpression of ACSL5 
                         Customized lentivirus expression plasmids for stable overexpression of ACSL5 
    Primer
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    OriGene qPCR primer pairs and template standards for ACSL5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSL5

    Additional mRNA sequence: 

    AB033899.1 AJ496489.1 AK000339.1 AK024932.1 AK222782.1 AK223288.1 AK301786.1 AK310436.1 
    AM262166.1 AY358520.1 BC007985.2 

    13 DOTS entries:

    DT.445254  DT.99927408  DT.75109374  DT.121284808  DT.95298959  DT.100781967  DT.100804348  DT.92427826 
    DT.95347878  DT.97812641  DT.97855857  DT.91683457  DT.92427832 

    24/226 AceView cDNA sequences (see all 226):

    CD370136 BQ684833 BM785041 NM_203379 AI928069 NM_203380 BM830057 BQ690117 
    BQ690081 AI677664 AI569416 BM839529 CB161735 BM855568 AI365079 CD244088 
    BM561533 AI989597 CB216670 AW009379 AI738642 BQ229959 AI760607 BG257195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACSL5 expression in normal human tissues (normalized intensities)      ACSL5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTCTAC
    ACSL5 Expression
    About this image


    ACSL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             Human Bladder Microvascular Endothelial Cells (HBdMEC)   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             Human Bladder Microvascular Endothelial Cells (HBdMEC)   
             visceral organ   
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Perivascular Adipose
             Human Mesenchymal Stem Cell-adipose (HMSC-ad)   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   

    See ACSL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACSL5

    SOURCE GeneReport for Unigene cluster: Hs.11638
        SABiosciences Expression via Pathway-Focused PCR Arrays including ACSL5: 
              Fatty Acid Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Fatty Liver in human mouse rat
              PPAR Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACSL5 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acsl51 , 5 acyl-CoA synthetase long-chain family member 51, 5 83.21(n)1
    81.41(a)1
      19 (51.30 cM)5
    4332561  NM_027976.21  NP_082252.11 
     552533695 
    chicken
    (Gallus gallus)
    Aves ACSL51 acyl-CoA synthetase long-chain family member 5 70.38(n)
    69.4(a)
      423896  NM_001031237.1  NP_001026408.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACSL56
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343204.1(1964896-1987009)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119462 Transcribed sequence with moderate similarity to protein more 72.38(n)    BX727325.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa04h022 wufa04h02 76.7(n)   334836  AA497359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39611 CG3961 55.21(n)
    50.31(a)
      40056  NM_140810.3  NP_649067.2 
    worm
    (Caenorhabditis elegans)
    Secernentea acs-131 Protein ACS-13 54.39(n)
    49.38(a)
      171643  NM_058343.2  NP_490744.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAA21 Faa2p 46.47(n)
    36.81(a)
      856734   NP_010931.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LACS71 long-chain acyl-CoA synthetase 7 52.49(n)
    46.75(a)
      832820  NM_122642.4  NP_198112.2 
    corn
    (Zea mays)
    Liliopsida Zm.30422 Zea mays CL741_1 mRNA sequence 75.56(n)    AY109410.1 


    ENSEMBL Gene Tree for ACSL5 (if available)
    TreeFam Gene Tree for ACSL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACSL5 gene
    ACSBG12  ACSL62  ACSBG22  ACSL12  
    6 SIMAP similar genes for ACSL5 using alignment to 2 protein entries:     ACSL5_HUMAN (see all proteins):
    FACL5    ACSL6    ACSL1    ACSL3    ACSL4    FACL4

    ACSL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1188 SNPs in ACSL5 are shown (see all 1188)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363784
    A colorectal cancer sample4--see VAR_0363782 G D mis40--------
    VAR_0363774
    A colorectal cancer sample4--see VAR_0363772 K R mis40--------
    rs1905425631,2
    --114131925(+) GTGGGA/GACATG 1 -- us2k10--------
    rs1388260751,2
    --114132043(+) ACGGAA/CCAATC 1 -- us2k10--------
    rs1419108811,2
    --114132091(+) ATGGAC/TCAATC 1 -- us2k10--------
    rs1463973311,2
    --114132143(+) CTGTCC/TGAGCC 1 -- us2k10--------
    rs1420078511,2
    --114132197(+) TTGTTC/GTTTAG 1 -- us2k10--------
    rs1817337121,2
    --114132225(+) TGCTAC/TTGCTC 1 -- us2k10--------
    rs1506744401,2
    --114132246(+) TCTACA/GCTGCT 1 -- us2k10--------
    rs1873734671,2
    --114132256(+) TTTTAC/TGAGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACSL5 (114133776 - 114188138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for ACSL5 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2190783CNV Deletion18987734
    esv2740995CNV Deletion23290073
    esv1472658CNV Deletion17803354
    esv2741017CNV Deletion23290073
    esv2740984CNV Deletion23290073
    esv2741006CNV Deletion23290073
    esv4752CNV Deletion18987735
    esv2546876CNV Deletion19546169
    esv7592CNV Loss19470904
    nsv508609CNV Loss20534489


    Human Gene Mutation Database (HGMD): ACSL5
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ACSL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605677    OMIM disorders: --

    7 diseases for ACSL5:    About MalaCards
    malignant glioma    hypertriglyceridemia    colorectal cancer    adenoma
    adenocarcinoma    alzheimer's disease    hepatitis


    ACSL5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for ACSL5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 39.3 11 16110457 (4), 16241998 (3), 14608540 (1)
    adenoma 24.9 4 16110457 (2), 14608540 (1)
    colorectal cancer 15.4 1 16110457 (1)

    Genetic Association Database (GAD): ACSL5
    Human Genome Epidemiology (HuGE) Navigator: ACSL5 (5 documents)

    Export disorders for ACSL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACSL5 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with ACSL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. (PubMed id 11127823)1, 3, 9 Yamashita Y....Yamamoto T.T. (2000)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions. (PubMed id 18806831)1, 2 Mashima T.... Seimiya H. (2009)
    5. Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. (PubMed id 17495181)1, 4 Adamo K.B....Tesson F. (2007)
    6. Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. (PubMed id 17681178)1, 2 Gassler N.... Kopitz J. (2007)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51703 HGNC: 16526 AceView: ACSL5 Ensembl:ENSG00000197142 euGenes: HUgn51703
    ECgene: ACSL5 Kegg: 51703 H-InvDB: ACSL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACSL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACSL5 gene:
    Search GeneIP for patents involving ACSL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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