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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACSL5 Gene

protein-coding GIFtS: 57
GCID: GC10P114123

acyl-CoA synthetase long-chain family member 5

(Previous names: fatty-acid-Coenzyme A ligase, long-chain 5 )
(Previous symbol: FACL5)

Explore 9 diseases affiliated with
ACSL5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acyl-CoA Synthetase Long-Chain Family Member 5¹ ²		EC 6.2.1.3³ ⁸
ACS5¹ ² ³ ⁵		FACL5 For Fatty Acid Coenzyme A Ligase 5²
FACL5¹ ² ³ ⁵		Fatty Acid Coenzyme A Ligase 5²
ACS2¹ ²		Long-Chain Fatty Acid Coenzyme A Ligase 5²
Fatty-Acid-Coenzyme A Ligase, Long-Chain 5¹ ²		Long-Chain-Fatty-Acid--CoA Ligase 5²
Long-Chain Acyl-CoA Synthetase 5² ³		EC 6.2.1⁸
LACS 5² ³

External Ids:	HGNC: 16526¹	Entrez Gene: 51703²	Ensembl: ENSG00000197142⁷	OMIM: 605677⁵	UniProtKB: Q9ULC5³

Export aliases for ACSL5 gene to outside databases

Previous GC identifers: GC10P113800 GC10P107761

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACSL5:

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although

differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family

convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and

fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain,

but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma

cell growth. Three transcript variants encoding two different isoforms have been found for this gene. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5

Function: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and

degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of

triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids

with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate

fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize

epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of

glioma cells

Gene Wiki entry for ACSL5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACSL5 gene promoter:
Sox5 p300 STAT5A Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ACSL5 promoter sequence

Search SABiosciences Chromatin IP Primers for ACSL5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSL5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1-q25.2 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q25.1-q25.2

ACSL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSL5 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P114123: view genomic region (about GC identifiers)

Start:	114,133,776 bp from pter	End:	114,188,138 bp from pter
Size:	54,363 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5 (See protein sequence)

Recommended Name: Long-chain-fatty-acid--CoA ligase 5

Size: 683 amino acids; 75991 Da

Cofactor: Magnesium (By similarity)

Subcellular location: Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III membrane

protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity)

Sequence caution: Sequence=BAA85979.1; Type=Erroneous initiation; Sequence=BAA86054.1; Type=Erroneous gene model

prediction;

Secondary accessions: D3DRB3 Q6UX44 Q9UIU4

Alternative splicing: 3 isoforms: Q9ULC5-1 Q9ULC5-3 Q9ULC5-4 (Localize in mitochondrion and endoplasmic reticulum)

Explore the universe of human proteins at neXtProt for ACSL5: NX_Q9ULC5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9ULC5

4/11 DME Specific Peptides for ACSL5 (Q9ULC5) (see all 11)

RKPNQPY

YGQTECT

LPLAHMFE

VPLYDTLG

ACSL5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_057318.2 NP_976313.1 NP_976314.1

ENSEMBL proteins:

ENSP00000346680 ENSP00000346223 ENSP00000348429 ENSP00000376796 ENSP00000403647

ENSP00000358418

Reactome Protein details: Q9ULC5
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	Novus Biologicals ACSL5 Proteins Novus Biologicals ACSL5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACSL5

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	17681178
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0005783	endoplasmic reticulum	IDA	17681178
GO:0005789	endoplasmic reticulum membrane	TAS	--

ACSL5 for ontologies About GeneDecksing

ACSL5 Antibody Products:

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	Novus Biologicals ACSL5 Antibodies
	Search for Antibodies for ACSL5 at Abcam
	Uscn Antibodies for ACSL5
	ThermoFisher Antibody for ACSL5

Assay Products for ACSL5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ACSL5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ACSL5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACSL5 for domains About GeneDecksing

2 InterPro domains/families:

IPR000873 AMP-dep_Synth/Lig

IPR020845 AMP-binding_CS

Graphical View of Domain Structure for InterPro Entry Q9ULC5

ProtoNet protein and cluster: Q9ULC5

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACSL5_HUMAN, Q9ULC5

Function: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and

degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of

triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids

with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate

fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize

epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of

glioma cells

Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA

Biophysicochemical properties: Kinetic parameters: KM=0.11 uM for palmitic acid (isoform 1 at pH 7.5); KM=0.38 uM for

palmitic acid (isoform 1 at pH 9.5); KM=0.04 uM for palmitic acid (isoform 3 at pH 7.5); KM=0.15 uM for palmitic acid

(isoform 3 at pH 8.5); pH dependence: Optimum pH is 9.5 (isoform 1), 7.5-8.5 (isoform 3);

Enzyme Numbers (IUBMB): EC 6.2.1.3¹ ² EC 6.2.1²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ACSL5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSL5
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSL5 (see all 10):
		hsa-miR-875-3p hsa-miR-218-1* hsa-miR-4267 hsa-miR-548g hsa-miR-3654 hsa-miR-2115 hsa-miR-1243 hsa-miR-375

		SwitchGear 3'UTR luciferase reporter plasmid: ACSL5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACSL5 (see all 7) OriGene shRNA RFP: ACSL5 OriGene siRNA: ACSL5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSL5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ACSL5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACSL5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACSL5 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ACSL5 (NM_203379)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ACSL5
		Search LifeMap BioReagents cell lines for ACSL5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL5

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004467	long-chain fatty acid-CoA ligase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016874	ligase activity	--	--

ACSL5 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Acsl5^tm1Lex for ACSL5
     1 MGI phenotypic allele

for Acsl5 (no phenotypes)

ACSL5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

fatty acid alpha-oxidation II

	fatty acid alpha-oxidation II	1.00			stearate biosynthesis I (animals)	0.43
	fatty acid activation	0.67			fatty acid beta-oxidation I	0.39

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Fatty Acyl-CoA Biosynthesis

	Fatty Acyl-CoA Biosynthesis	1.00			Triglyceride Biosynthesis	0.47
	Synthesis of very long-chain fatty acyl-CoAs	0.78

eicosapentaenoate biosynthesis II (metazoa)

eicosapentaenoate biosynthesis II (metazoa)

1.00

gamma-linolenate biosynthesis II (animals)

0.69

Fatty Acid Beta Oxidation

Fatty Acid Beta Oxidation

1.00

Fatty acid metabolism

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 BioSystems Pathways for ACSL5 (see all 8)

	fatty acid alpha-oxidation II
	stearate biosynthesis I (animals)
	fatty acid beta-oxidation I
	Fatty Acid Beta Oxidation
	gamma-linolenate biosynthesis II (animals)

5/6 Reactome Pathways for ACSL5 (see all 6)

	Metabolism
	Synthesis of very long-chain fatty acyl-CoAs
	Triglyceride Biosynthesis
	Fatty Acyl-CoA Biosynthesis
	Fatty acid, triacylglycerol, and ketone body metabolism

5 Kegg Pathways (Kegg details for ACSL5):

	Fatty acid metabolism
	Metabolic pathways
	PPAR signaling pathway
	Peroxisome
	Adipocytokine signaling pathway

ACSL5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ACSL5

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/25 Interacting proteins for ACSL5 (Q9ULC5³ ENSP00000348429⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREB3	O43889³	I2D: score=1
ACADL	ENSP00000233710⁴	STRING: ENSP00000233710
ACADM	ENSP00000409612⁴	STRING: ENSP00000409612
ACADVL	ENSP00000325395⁴	STRING: ENSP00000325395
ACOX1	ENSP00000293217⁴	STRING: ENSP00000293217

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001676	long-chain fatty acid metabolic process	IDA	17681178
GO:0006631	fatty acid metabolic process	--	--
GO:0007584	response to nutrient	--	--
GO:0009744	response to sucrose stimulus	--	--
GO:0009749	response to glucose stimulus	--	--

ACSL5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ACSL5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACSL5

10/41 HMDB Compounds for ACSL5 (see all 41) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
20-COOH-leukotriene E4	20-COOH-LTE4 (see all 3)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
6,9,12,15,18,21-Tetracosahexaenoic acid	all-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)	--	--

5 Novoseek chemical compound relationships for ACSL5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
1-aminocyclopropane-1-carboxylate	80.5	1	9539813 (1)
cytokinin	77.9	10	9539813 (1), 15118728 (1), 18980656 (1)
acyl-coa	76.3	5	15051725 (1), 15736044 (1), 16241998 (1), 15885896 (1) (see all 5)
ethylene	73.1	9	9539813 (3), 15118728 (2), 18808454 (1)
fatty acid	46.4	4	15051725 (1), 11127823 (1), 16241998 (1)

Search CenterWatch for drugs/clinical trials and news about ACSL5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACSL5 gene (3 alternative transcripts):

NM_016234.3 NM_203379.1 NM_203380.1

Unigene Cluster for ACSL5:

Acyl-CoA synthetase long-chain family member 5

Hs.11638 [show with all ESTs]

Unigene Representative Sequence: NM_203380

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354655(uc001kzs.3) ENST00000479936 ENST00000354273(uc009xxz.3 uc010qrj.2)

ENST00000495539 ENST00000467340 ENST00000496328 ENST00000356116(uc001kzu.3)

ENST00000393081(uc001kzt.3) ENST00000433418 ENST00000369410

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ACSL5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSL5
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSL5 (see all 10):
		hsa-miR-875-3p hsa-miR-218-1* hsa-miR-4267 hsa-miR-548g hsa-miR-3654 hsa-miR-2115 hsa-miR-1243 hsa-miR-375

		SwitchGear 3'UTR luciferase reporter plasmid: ACSL5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACSL5 (see all 7) OriGene shRNA RFP: ACSL5 OriGene siRNA: ACSL5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSL5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACSL5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACSL5 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ACSL5 (NM_203379)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSL5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL5

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ACSL5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSL5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSL5

Additional cDNA sequence:

AB033899.1 AJ496489.1 AK000339.1 AK024932.1 AK222782.1 AK223288.1 AK301786.1 AK310436.1

AM262166.1 AY358520.1 BC007985.2

13 DOTS entries:

DT.445254 DT.99927408 DT.75109374 DT.121284808 DT.95298959 DT.100781967 DT.100804348 DT.92427826

DT.95347878 DT.97812641 DT.97855857 DT.91683457 DT.92427832

24/226 AceView cDNA sequences (see all 226):

AW009379 BG754711 AI367368 AI619909 AY358520 BX404984 AI738642 BG257195

BM788860 AA767389 CB216670 BQ229959 AA648989 AI569416 BE293689 BQ684833

AK024932 BU626754 AI203282 NM_203379 AI989597 AF202338 AI870460 AL708807

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACSL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTTCTAC

About this image

ACSL5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Hindgut

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

White adipocyte-like cells (Differentiation of ...)

Adipose

See ACSL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACSL5

SOURCE GeneReport for Unigene cluster: Hs.11638

SABiosciences Expression via Pathway-Focused PCR Arrays including ACSL5:

Fatty Acid Metabolism in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

Fatty Liver in human mouse rat

PPAR Targets in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACSL5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ACSL5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSL5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSL5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL5 gene from 9/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACSL5¹	acyl-CoA synthetase long-chain family member 5	70.38(n) 69.4(a)		423896 NM_001031237.1 NP_001026408.1
lizard (Anolis carolinensis)	Reptilia	ACSL5⁶	--	68(a)	1 ↔ 1	GL343204.1(1964896-1987009)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.11946²	Transcribed sequence with moderate similarity to protein more	72.38(n)		BX727325.1
zebrafish (Danio rerio)	Actinopterygii	wufa04h02²	wufa04h02	76.7(n)		334836 AA497359.1
fruit fly (Drosophila melanogaster)	Insecta	CG3961¹	CG3961	55.21(n) 50.31(a)		40056 NM_140810.3 NP_649067.2
worm (Caenorhabditis elegans)	Secernentea	acs-13¹	Protein ACS-13	54.39(n) 49.38(a)		171643 NM_058343.2 NP_490744.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	FAA2¹	Faa2p	46.47(n) 36.81(a)		856734 NP_010931.3
thale cress (Arabidopsis thaliana)	eudicotyledons	LACS7¹	long-chain acyl-CoA synthetase 7	52.49(n) 46.75(a)		832820 NM_122642.4 NP_198112.2
rice (Oryza sativa)	Liliopsida	-- -- (see all 7)	acyl-CoA synthetase protein, putative, expressed (see all 7)	38(a) 38(a) (see all 7)	possible ortholog possible ortholog (see all 7)	12(2160546-2169072) 11(2127753-2137256)

ENSEMBL Gene Tree for ACSL5 (if available)
TreeFam Gene Tree for ACSL5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ACSL5 gene

ACSBG1² ACSL3² ACSL6² ACSL4² ACSBG2² ACSL1²

6 SIMAP similar genes for ACSL5 using alignment to 2 protein entries: ACSL5_HUMAN (see all proteins):

FACL5 ACSL6 ACSL1 ACSL3 ACSL4 FACL4

ACSL5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs190542563^1,2	--	114131925(+)	`GTGGGA/GACATG`	1	--	us2k¹		0	--	--	--	--
rs138826075^1,2	--	114132043(+)	`ACGGAA/CCAATC`	1	--	us2k¹		0	--	--	--	--
rs141910881^1,2	--	114132091(+)	`ATGGAC/TCAATC`	1	--	us2k¹		0	--	--	--	--
rs146397331^1,2	--	114132143(+)	`CTGTCC/TGAGCC`	1	--	us2k¹		0	--	--	--	--
rs142007851^1,2	--	114132197(+)	`TTGTTC/GTTTAG`	1	--	us2k¹		0	--	--	--	--
rs181733712^1,2	--	114132225(+)	`TGCTAC/TTGCTC`	1	--	us2k¹		0	--	--	--	--
rs150674440^1,2	--	114132246(+)	`TCTACA/GCTGCT`	1	--	us2k¹		0	--	--	--	--
rs187373467^1,2	--	114132256(+)	`TTTTAC/TGAGCT`	1	--	us2k¹		0	--	--	--	--
rs192094234^1,2	--	114132257(+)	`TTTATA/GAGCTG`	1	--	us2k¹		0	--	--	--	--
rs139867799^1,2	--	114132268(+)	`TAATGC/TTCACT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ACSL5 (114133776 - 114188138 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for ACSL5
4 CNVs: 85486 34848 101046 34847
5 Indels: 44665 61062 39782 24328 42368
Human Gene Mutation Database (HGMD): ACSL5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACSL5

DNA2.0 Custom Variant and Variant Library Synthesis for ACSL5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ACSL5 for disorders           About GeneDecksing

OMIM gene information: 605677    OMIM disorders: --

9 diseases for ACSL5:    About MalaCards

malignant glioma placental cancer hypertriglyceridemia colorectal cancer

alzheimer's disease adenocarcinoma cholesterol hepatitis

malaria

3 Novoseek disease relationships for ACSL5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenocarcinoma	39.3	11	16110457 (4), 16241998 (3), 14608540 (1)
adenoma	24.9	4	16110457 (2), 14608540 (1)
colorectal cancer	15.4	1	16110457 (1)

Human Genome Epidemiology (HuGE) Navigator: ACSL5 (5 documents)

Export disorders for ACSL5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ACSL5 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with ACSL5)

Utopia: connect your pdf to the dynamic
world of online information

Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. (PubMed id 11127823)^{1, 3, 9} Yamashita Y....Yamamoto T.T. (2000)
Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions. (PubMed id 18806831)^{1, 2} Mashima T.... Seimiya H. (2009)
Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. (PubMed id 17681178)^{1, 2} Gassler N.... Kopitz J. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5. (PubMed id 15809837)^{1, 9} Obermuller N....Gassler N. (2006)
Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5. (PubMed id 15736044)^{1, 9} Gassler N....Autschbach F. (2005)
Impaired expression of acyl-CoA-synthetase 5 in epithelial tumors of the small intestine. (PubMed id 14608540)^{1, 9} Gassler N....Autschbach F. (2003)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51703	HGNC: 16526	AceView: ACSL5	Ensembl:ENSG00000197142	euGenes: HUgn51703
ECgene: ACSL5	Kegg: 51703	H-InvDB: ACSL5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ACSL5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACSL5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACSL5 gene:
Search GeneIP for patents involving ACSL5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ACSL5 Gene

acyl-CoA synthetase long-chain family member 5

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ACSL5 Gene

acyl-CoA synthetase long-chain family member 5

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