ACSL4 Gene
protein-coding GIFtS : 68
GCID: GC0X M108872
acyl-CoA synthetase long-chain family member 4 (Previous names: fatty-acid-Coenzyme A ligase, long-chain 4, mental retardation,... ) (Previous symbols: FACL4, MRX63, MRX68 )
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Aliasesfor ACSL4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Acyl-CoA Synthetase Long-Chain Family Member 4 1 2 LACS 42 3 ACS41 2 3 5 EC 6.2.1.33 8 FACL41 2 3 5 Mental Retardation, X-Linked 631 LACS41 2 3 Mental Retardation, X-Linked 681 MRX631 2 5 Acyl-CoA Synthetase 42 MRX681 2 Lignoceroyl-CoA Synthase2 Fatty-Acid-Coenzyme A Ligase, Long-Chain 41 2 Long-Chain Fatty-Acid-Coenzyme A Ligase 42 Long-Chain Acyl-CoA Synthetase 42 3 Long-Chain-Fatty-Acid--CoA Ligase 42
Export aliases for ACSL4 gene to outside databases Previous GC identifers: GC0XM107649 GC0XM108690 GC0XM108771 GC0XM108884 GC0XM098507
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Summariesfor ACSL4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ACSL4 : The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488 Function : Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation viabeta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates Gene Wiki entry for ACSL4
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Genomic Viewsfor ACSL4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011651.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ACSL4 gene promoter: Egr-3 SRF USF1 SRF (504 AA) AP-2gamma LCR-F1 USF-1 AP-2beta AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for ACSL4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ACSL4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq22.3-q23 Ensembl cytogenetic band: Xq23 HGNC cytogenetic band: Xq22.3-q23 ACSL4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM108872: view genomic region
(about GC identifiers )
Start:
108,872,579 bp from pter
End:
108,976,632 bp from pter
Size:
104,054 bases
Orientation:
minus strand
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Proteinsfor ACSL4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488 (See
protein sequence )Recommended Name: Long-chain-fatty-acid--CoA ligase 4 Size : 711 amino acids; 79188 Da
Cofactor : Magnesium (By similarity)
Subcellular location : Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisomemembrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity)
Secondary accessions : D3DUY2 O60848 O60849Alternative splicing : 2 isoforms : O60488-1 O60488-2 Explore the universe of human proteins at neXtProt for ACSL4: NX_O60488 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O60488 4/9 DME Specific Peptides for ACSL4 (O60488 ) (see all 9 )ACSL4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_004449.1 NP_075266.1 ENSEMBL proteins: ENSP00000262835 ENSP00000419171 ENSP00000423539 ENSP00000424808 ENSP00000425408 ENSP00000425378 ENSP00000421425 ENSP00000423077 ENSP00000339787 Reactome Protein details: O60488 Human Recombinant Protein Products: Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12 ): About this table
ACSL4 for ontologies About GeneDecksing ACSL4 Antibody Products: Assay Products for ACSL4:
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Protein
Domains / Familiesfor ACSL4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ACSL4 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O60488 ProtoNet protein and cluster: O60488
1 Blocks protein family : IPB000873 AMP-binding signature UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488 Similarity : Belongs to the ATP-dependent AMP-binding enzyme family
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Functionfor ACSL4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488 Function : Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation viabeta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates Catalytic activity : ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoAEnzyme Number (IUBMB): EC 6.2.1.3 1 2
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACSL4 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACSL4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ACSL4 (NM_022977 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACSL4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACSL4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL4
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
ACSL4 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for ACSL4 :Animal Models: Mouse knock-out Acsl4 tm1Tty for ACSL4 9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Acsl4) :
ACSL4 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ACSL4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Metabolism 2 Fatty Acid Beta Oxidation 3 Fatty Acyl-CoA Biosynthesis 4 Fatty Acid Biosynthesis 5 Peroxisome
Pathway sources See GeneCards unified pathways Show all pathways 3 BioSystems Pathways for ACSL4 5/6
Reactome Pathways for ACSL4 (see all 6 )5
Kegg Pathways (Kegg details for ACSL4) :
ACSL4 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACSL4 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/69 Interacting proteins for ACSL4 (O60488 2 , 3 ENSP00000339787 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 69 )About this table Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15 ): About this table
ACSL4 for ontologies About GeneDecksing
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Drugs & Compoundsfor ACSL4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ACSL4 for compounds About GeneDecksing Browse Tocris compounds for ACSL4 10/41 HMDB Compounds for ACSL4 (see all 41 ) About this table Compound Synonyms
CAS
# PubMed Ids (2E)-Decenoyl-CoA (E)-S-2-decenoate Coenzyme A (see all 15 ) 10018-95-8 -- (2E)-Dodecenoyl-CoA 2-trans-Dodecenoyl-Coenzyme A (see all 4 ) 1066-12-2 -- (2E)-Hexadecenoyl-CoA trans-2-Hexadecenoyl-CoA (see all 4 ) 4460-95-1 -- (2E)-Octenoyl-CoA (E)-S-2-octenoate Coenzyme A (see all 16 ) 10018-94-7 -- (2E)-Tetradecenoyl-CoA (2E)-Tetradecenoyl-Coenzyme A (see all 8 ) 38795-33-4 -- 2-Methylbutyryl-CoA 2-methylbutanoyl-CoA (see all 11 ) 6712-02-3 -- 2-Methylhexanoyl-CoA 2-Methylhexanoyl-CoEnzyme A (see all 5 ) -- -- 20-COOH-leukotriene E4 20-COOH-LTE4 (see all 3 ) -- -- 3Z-dodecenoyl-CoA S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4 ) 2152-91-2 -- 6,9,12,15,18,21-Tetracosahexaenoic acid all-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8 ) -- --
3 DrugBank Compounds for ACSL4 About this table 5 Novoseek chemical compound relationships for ACSL4 gene About this table
Search CenterWatch for drugs/clinical trials and news about ACSL4
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Transcriptsfor ACSL4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ACSL4 gene (2 alternative transcripts): NM_004458.2 NM_022977.2 Unigene Cluster for ACSL4:
Acyl-CoA synthetase long-chain family member 4 Hs.268785 [show with all ESTs ] Unigene Representative Sequence: NM_022977 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000505075 ENST00000348502 (uc004eoj.2 ) ENST00000469796 ENST00000514500 ENST00000505855 ENST00000502391 ENST00000508092 ENST00000504980 ENST00000469857 ENST00000504383 ENST00000340800 (uc004eoi.2 uc004eok.2 uc010npp.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACSL4 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACSL4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ACSL4 (NM_022977 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACSL4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACSL4
Additional cDNA sequence: AB061713.1 AB061714.1 AF030555.1 AK054631.1 AK292070.1 AK294197.1 AK294915.1 AK307566.1 BC034959.2 Y12777.1 Y13058.1
15 DOTS entries : DT.317429 DT.99998784
DT.92436948 DT.100814367 DT.105846 DT.121301757 DT.100802668 DT.121301738 DT.121301650 DT.121301752 DT.100814371 DT.121301762 DT.40117087 DT.91830694 DT.92436949 24/231 AceView cDNA sequences (see all 231 ):
Z43734 BM800997 AI540829 AA633818 AL550201 CA450610 BM452675 AI610538 BM977314 BM930104 AA831304 AW089807 AI359286 AA251792 BM684738 BQ008315 BU634080 AI269401 Z39796 CR603171 AL705114 CB159241 BQ050038 BM974237 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ACSL4 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ SP1 :             -   -   -                                     SP2 :             -   -   -                                     SP3 :             -                                         SP4 :           -   -                                         SP5 :             -   -                                      
ExUns: 16 SP1 :   SP2 :   SP3 :   SP4 :   SP5 :  
ECgene alternative splicing isoforms for ACSL4
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Expression for ACSL4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ACSL4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTATCAAAAA
About this image ACSL4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ACSL4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ACSL4 SOURCE GeneReport for Unigene cluster: Hs.268785 SABiosciences Expression via Pathway-Focused PCR Arrays including ACSL4 (see all 6 ): Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ACSL4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ACSL4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ACSL4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ACSL4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL4
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Orthologsfor ACSL4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ACSL4 gene from 8/26 species (see all 26 ) About this table
ENSEMBL Gene Tree for ACSL4 (if available)TreeFam Gene Tree for ACSL4 (if available)
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Paralogsfor ACSL4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ACSL4 gene ACSBG1 2 ACSL3 2 ACSL6 2 ACSBG2 2 ACSL1 2 ACSL5 2 6 SIMAP similar genes for ACSL4 using alignment to 7 protein entries: ACSL4_HUMAN (see all proteins ):FACL4 ACSL3 ACSL5 ACSL6 FACL5 ACSL1
ACSL4 for paralogs About GeneDecksing
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Genomic Variantsfor ACSL4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ACSL4 (108872579 - 108976632 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for ACSL4 3 CNVs : 96890 1862 4163 2 Indels : 96891 83677 Human Gene Mutation Database (HGMD) : ACSL4 Locus Specific Mutation Databases (LSDB): ACSL4 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ACSL4
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Disorders
/ Diseasesfor ACSL4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ACSL4 for disorders About GeneDecksing OMIM gene information: 300157 OMIM disorders : 300387 UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488
Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63) [MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]. A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis 20/21 diseases for ACSL4 (see all 21 ): About MalaCards mental retardation, x-linked mental retardation, x-linked nonspecific, 63 mental retardation, x-linked, nonspecific alport syndrome alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis elliptocytosis autism spectrum disorder intellectual disability insulin resistance colon adenocarcinoma mental disorders hepatocellular carcinoma hypotonia adenocarcinoma schizophrenia nephropathy prostate cancer carcinoma prostatitis hepatitis 2 diseases from the University of Copenhagen DISEASES database for ACSL4 :Intellectual disability Alport syndrome 10/11 Novoseek disease relationships for ACSL4 gene (see all 11 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
alports syndrome
77.1
3
9480748 (1), 20186809 (1), 12525535 (1)
elliptocytosis hereditary
70
1
9480748 (1)
mental retardation
59.5
15
18614287 (4), 11889465 (3), 12525535 (2), 9480748 (1) (see all 7 )
colon adenocarcinoma
56.4
2
12824887 (1), 11731423 (1)
hepatocellular carcinoma
28.2
5
18059177 (1), 12824887 (1), 15849811 (1), 17934335 (1)
colon cancer
26.7
3
15849811 (1), 11731423 (1)
adenoma
14.5
4
11731423 (1)
schizophrenia
1.56
1
15108178 (1)
adenocarcinoma
0.199
3
11731423 (2)
tumors
0
4
12824887 (1), 11731423 (1), 10924347 (1), 20360933 (1)
Genetic Association Database (GAD): ACSL4 Human Genome Epidemiology (HuGE) Navigator: ACSL4 (7 documents) Export disorders for ACSL4 gene to outside databases
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Publicationsfor ACSL4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ACSL4 gene, integrated from 9 sources (see all 69 ): (articles sorted by number of sources associating them with ACSL4) Utopia : connect your pdf to the dynamic world of online information
Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. (PubMed id 15108178) 1 , 4, 7, 9 Covault J....Kranzler H.R. (2004) FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation. (PubMed id 9480748) 1 , 2 , 3, 9 Piccini M....Renieri A. (1998) Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4). (PubMed id 9598324) 1 , 2 , 9 Cao Y.... Prescott S.M. (1998) FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X- linked mental retardation. (PubMed id 11889465) 1 , 2 , 9 Meloni I.... Renieri A. (2002) Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24. (PubMed id 12949969) 1 , 3, 9 Verot L....Edery P. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells. (PubMed id 17934335) 1 , 9 Sung Y.K....Kim M.K. (2007) Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. (PubMed id 11731423) 1 , 9 Cao Y....Prescott S.M. (2001) Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase. (PubMed id 15849811) 1 , 9 Liang Y.C....Lin S.Y. (2005) Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma. (PubMed id 12824887) 1 , 9 Sung Y.K....Kim M. (2003)
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External Searches for ACSL4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ACSL4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing ACSL4 gene
(According to HUGE )
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Specialized Databases showing ACSL4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ACSL4 Pharmacogenomics, SNPs, Pathways GeneReviews http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ACSL4
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About This Section Patent Information for ACSL4 gene: Search GeneIP for patents involving ACSL4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ACSL4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ACSL4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ACSL4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ACSL4 OriGene Protein Over-expression Lysate for ACSL4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ACSL4 OriGene 3'-UTR Clone for ACSL4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACSL4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACSL4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ACSL4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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ACSL4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL4
ThermoFisher Antibodies for ACSL4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACSL4
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