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ACSL4 Gene

protein-coding GIFtS: 65

GC0XM108771

acyl-CoA synthetase long-chain family member 4
(Previous names: fatty-acid-Coenzyme A ligase, long-chain 4, mental retardation, X-linked 63, mental retardation, X-linked 68 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FACL4, MRX63, MRX68)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACS4 ^¹, ², ³, ⁵
EC 6.2.1.3 ^³
FACL4 ^², ³, ⁵
LACS4 ^¹, ², ³
MRX63 ^², ⁵
MRX68 ^²
OTTHUMP00000023846 ^²

Descriptions
LACS 4 ^³
Long-chain acyl-CoA synthetase 4 ^³
acyl-CoA synthetase 4 ^²
acyl-CoA synthetase long-chain family member 4 ^²
fatty-acid-Coenzyme A ligase, long-chain 4 ^¹, ²
lignoceroyl-CoA synthase ^²
long-chain fatty-acid-Coenzyme A ligase 4 ^²
mental retardation, X-linked 63 ^¹
mental retardation, X-linked 68 ^¹

External Ids
HGNC: 3571¹
Entrez Gene: 2182²
UniProtKB: O60488³
Ensembl: ENSG00000068366⁷

Search outside databases for aliases for ACSL4 gene

Previous GC identifers: GC0XM107649 GC0XM108690

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACSL4:

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase

family. Although differing in substrate specificity, subcellular localization, and tissue

distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA

esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme

preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to

the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2

transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488

Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and

degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as

substrates

Gene Wiki entry for ACSL4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACSL4 gene

Entrez Gene cytogenetic band: Xq22.3-q23 Ensembl cytogenetic band: Xq22.3 HGNC cytogenetic band: Xq22.3-q23

ACSL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM108771: (about GC identifiers)

Start:	108,771,220 bp from pter
End:	108,863,277 bp from pter
Size:	92,058 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011651.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488 (See protein sequence)

Recommended Name: Long-chain-fatty-acid--CoA ligase 4

Size: 711 amino acids; 79188 Da

Cofactor: Magnesium (By similarity)

Subcellular location: Mitochondrion outer membrane; Single-pass type III membrane protein (By

similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome

membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane;

Single-pass type III membrane protein (By similarity)

Secondary accessions: O60848 O60849

Alternative splicing: 2 isoforms: O60488-1 O60488-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004449.1 NP_075266.1

ENSEMBL proteins:

ENSP00000262835 ENSP00000385157 ENSP00000339787 ENSP00000361149

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FACL4)
	Human Recombinant Proteins from Abnova (ACSL4)

OriGene Purified Recombinant Human Protein: ACSL4

5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0005739	mitochondrion	IEA	--
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0005777	peroxisome	IEA	--
GO:0005778	peroxisomal membrane	IEA	--

About this table

Antibodies for ACSL4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACSL4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FACL4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACSL4)
	Novus Biologicals Antibody for ACSL4

Assays for ACSL4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O60488

ProtoNet protein and cluster: O60488

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACSL4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACSL4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_022977

Applied Biosystems Silencer® siRNAs for ACSL4

Sigma-Aldrich siRNA for ACSL4

Sigma-Aldrich shRNA for ACSL4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACSL4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004458
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004458
untagged cDNA clones in CMV expression vector (see all 2): NM_004458

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022977

UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488

Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and

degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as

substrates

Catalytic activity: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

Enzyme Number (IUBMB): EC 6.2.1.3

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Acsl4):

endocrine/exocrine gland

homeostasis/metabolism

normal

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004467	long-chain-fatty-acid-CoA ligase activity	TAS	9480748
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for ACSL4 (Your Favorite Gene powered by Ingenuity)

Fatty Acid Metabolism
Type II Diabetes Mellitus Signaling
LPS/IL-1 Mediated Inhibition of RXR Function

GeneDecks ACSL4 for the pathways selected above

About GeneDecksing

5/37 Interacting proteins for ACSL4 (ENSP00000339787³ O60488²) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²	MINT-3304385
AMMECR1	ENSP00000262844³	STRING (score=.947)
COL4A5	ENSP00000331902³	STRING (score=.946)
CPT1A	ENSP00000265641³	STRING (score=.93)
ACOX1	ENSP00000301608³	STRING (score=.915)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	NAS	9598324
GO:0006631	fatty acid metabolic process	IEA	--
GO:0007611	learning or memory	TAS	9480748
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACSL4
5 Novoseek chemical compound relationships for ACSL4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acyl-coa	79.57	16	9480748 (3), 11485311 (1), 15108178 (1), 15794766 (1) (see all 9)
arachidonic acid	66.86	28	15108178 (3), 10924347 (3), 11005842 (2), 15794766 (2) (see all 10)
fatty acid	39.60	1	11889465 (1)
acth	35.13	4	10924347 (2), 16630718 (1), 15956337 (1)
steroid	23.84	1	15794766 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACSL4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACSL4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_022977

Sigma-Aldrich siRNA for ACSL4

Sigma-Aldrich shRNA for ACSL4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004458 NM_022977

REFSEQ mRNAs for ACSL4 gene (2 alternative transcripts):

NM_004458.2 NM_022977.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004458 NM_022977

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004458
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004458
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004458

Additional cDNA sequence:

AB061713.1 AB061714.1 AF030555.1 AJ227865.1 AK292070.1 AK294197.1 AK294915.1 AK307566.1

BC034959.2 CR603171.1 Y12777.1 Y13058.1

14 DOTS entries:

DT.317429 DT.99998784 DT.92436948 DT.100814367 DT.121301757 DT.121301738 DT.121301650 DT.121301752

DT.91830694 DT.100814371 DT.121301762 DT.40117087 DT.100802668 DT.99926904

24/231 AceView cDNA sequences (see all 231 ):

AI540829 BM930104 AI282399 AA831304 AI610538 AI305180 CA450610 BG392638

BX371469 AA633818 AB061714 AL550201 Z43734 BQ050038 AA232192 CA446060

CB154092 CB243526 AI269401 N33823 AA251792 AI359286 AW089807 AI367469

highest scoring ESTs for ACSL4:

AF030555 AB061713 AB061714 AL036290 AL691592 AL701685 AL708850 AV693478 AV694590 BC034959

Unigene Cluster for ACSL4:

Acyl-CoA synthetase long-chain family member 4

Hs.268785 [show with all ESTs]

Unigene Representative Sequence: NM_022977

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ACSL4 (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^
SP1:													-		-		-
SP2:													-		-		-
SP3:													-
SP4:											-		-
SP5:													-		-

ExUns:	16
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ACSL4

4 Ensembl transcripts including schematic representations:

ENST00000348502 ENST00000407441 ENST00000340800 ENST00000372078

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACSL4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACSL4

¹ / ² / ³

6 probe-sets matching ACSL4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38099_r_at²^{, 3}	U95-A	1	1.00	1.00	0.80	0.81	AF030555	1.00	1.00	1.00	1
67487_at*²^{, 3}	U95-E	1	1.00	1.00	0.69	1.20	W95006	0.40	1.00	0.76	1
202422_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_022977	0.60	1.00	0.82	1
202422_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1557418_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1557419_a_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACSL4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTATCAAAAA

SOURCE GeneReport for Unigene cluster: Hs.268785
Expression variation in blood from EXPOLDB for ACSL4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACSL4 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACSL4¹	--	acyl-CoA synthetase long-chain family member 4	93.86(n) 97.47(a)	481018 XM_538140.2 XP_538140.2
cow (Bos taurus)	ACSL4¹	--	acyl-CoA synthetase long-chain family member 4	93.48(n) 96.27(a)	536628 XM_865924.2 XP_871017.2
rat (Rattus norvegicus)	Acsl4¹	--	acyl-CoA synthetase long-chain family member 4	91(n) 97.46(a)	113976 NM_053623.1 NP_446075.1
mouse (Mus musculus)	Acsl4^{1, 5}	X⁵	acyl-CoA synthetase long-chain family member 4^{1, 5}	92.69(n)¹ 96.77(a)¹	50790¹ NM_207625.2¹ NP_997508.1¹ AA466721⁵ AA619207⁵ (see all 24)
chicken (Gallus gallus)	ACSL4¹	--	acyl-CoA synthetase long-chain family member 4	79.35(n) 86.72(a)	422345 XM_420317.2 XP_420317.2

About this table Species with no ortholog for ACSL4

ENSEMBL Gene Tree for ACSL4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ACSL4 gene

ACSL3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/187 NCBI SNPs in ACSL4 are shown (see all 187 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1802109^1,2	A,C,F,H	108773860(-)	`TCAACC/TTCTAG`	2	--	ut3¹ ese³		4		EU EA WA	418
	rs5943428^1,2	A,C,F,H	108864521(+)	`TTCAAG/AATTGA`	2	--	ng3¹ tfbs³		4		EU EA WA	418
	rs10126612^1,2	F,H	108773756(+)	`TAAACC/TGGACA`	2	--	ut3¹ ese³		4		EU EA WA	418
	rs1063544^1,2	C	108772848(-)	`TTTAAG/TTTTAG`	2	--	ut3¹		0	--	--	--	--
	rs2147518^1,2	A,C,F,H,O	108853081(-)	`AATATT/GAAACA`	2	--	int¹		10		NA EA EU WA	771
	rs1324805^1,2	A,C,F,H,O	108849318(-)	`GTTGAT/CACTTG`	2	--	int¹		11		EA NA EU WA	830
	rs5943418^1,2	A,C,F,H	108832763(+)	`tgaacG/Aatcaa`	2	--	int¹		4		EU EA WA	418
	rs5943421^1,2	A,C,F,H	108841644(+)	`cctctA/Gctatt`	2	--	int¹		8		EU EA WA NA	606
	rs4893538^1,2	A,C,F,H	108860497(+)	`CATACG/TTGACA`	2	--	int¹		12		EU EA WA NS NA	613
	rs5942830^1,2	A,C,F,H	108804413(+)	`TGTTGT/CAATTC`	2	--	int¹		7		EU EA WA NA	529

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HapMap Linkage Disequilibrium images for ACSL4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300157 disorders: 300387

UniProtKB/Swiss-Prot: ACSL4_HUMAN, O60488

Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63)

[MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average

general intellectual functioning associated with impairments in adaptative behavior and manifested

during the developmental period. Non-syndromic mental retardation patients do not manifest other

clinical signs

Defects in ACSL4 may be a cause of AMME complex [MIM:300194]; also known as Alport

syndrome with mental retardation, midface hypoplasia and elliptocytosis. The AMME complex is a

contiguous gene deletion syndrome

10/11 Novoseek disease relationships for ACSL4 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
elliptocytosis hereditary	71.40	1	9480748 (1)
alports syndrome	69.06	2	9480748 (1), 12525535 (1)
colon adenocarcinoma	58.29	2	12824887 (1), 11731423 (1)
mental retardation	58.23	15	18614287 (4), 11889465 (3), 12525535 (2), 9480748 (1) (see all 7)
hepatocellular carcinoma	31.00	5	18059177 (1), 12824887 (1), 15849811 (1), 17934335 (1)
colon cancer	29.58	3	15849811 (1), 11731423 (1)
adenoma	16.98	4	11731423 (1)
schizophrenia	4.72	1	15108178 (1)
adenocarcinoma	3.06	3	11731423 (2)
cancer	0.00	2	18059177 (2)

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Human Gene Mutation Database: ACSL4
Genetic Association Database: ACSL4
Human Genome Epidemiology Navigator: ACSL4 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/37 PubMed articles for ACSL4 gene (see all 37 ):

FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation. (PubMed id 9480748)^{1, 2, 3, 4} Piccini M....Renieri A. (1998)
Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. (PubMed id 15108178)^{1, 3, 6} Covault J....Kranzler H.R. (2004)
Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4). (PubMed id 9598324)^{1, 3, 4} Cao Y.... Prescott S.M. (1998)
FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X- linked mental retardation. (PubMed id 11889465)^{1, 3, 4} Meloni I.... Renieri A. (2002)
Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24. (PubMed id 12949969)^{1, 2, 3} Verot L....Edery P. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells. (PubMed id 17934335)^{1, 3} Sung Y.K....Kim M.K. (2007)
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. (PubMed id 11731423)^{1, 3} Cao Y....Prescott S.M. (2001)
Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase. (PubMed id 15849811)^{1, 3} Liang Y.C....Lin S.Y. (2005)
Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma. (PubMed id 12824887)^{1, 3} Sung Y.K....Kim M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2182	HGNC: 3571	AceView: ACSL4	Ensembl:ENSG00000068366	euGenes: HUgn2182
ECgene: ACSL4	H-InvDB: ACSL4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ACSL4

Licensable Technologies for ACSL4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACSL4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACSL4-related products

	Millipore Custom Antibody & Bulk Services
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Antibodies for ACSL4

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ACSL4 Gene at Home site.
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ACSL4 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ACSL4

Summaries
for ACSL4

Genomic Location
for ACSL4

Proteins
for ACSL4

Protein Domains/
Families
for ACSL4

Gene Function
for ACSL4

Pathways & Interactions
for ACSL4

Drugs & Compounds
for ACSL4

Transcripts
for ACSL4

Expression
for ACSL4

Orthologs
for ACSL4

Paralogs
for ACSL4

SNPs/Variants
for ACSL4

Disorders & Mutations
for ACSL4

Medical News
for ACSL4

Publications
for ACSL4

Search for ACSL4

Genome Databases showing ACSL4

Other Databases showing ACSL4

Specialized Databases showing ACSL4

Licensable Technologies
for ACSL4

Services
for ACSL4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACSL4 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ACSL4

Summariesfor ACSL4

Genomic Locationfor ACSL4

Proteinsfor ACSL4

Protein Domains/Familiesfor ACSL4

Gene Functionfor ACSL4

Pathways & Interactionsfor ACSL4

Drugs & Compoundsfor ACSL4

Transcriptsfor ACSL4

Expression for ACSL4

Orthologsfor ACSL4

Paralogsfor ACSL4

SNPs/Variantsfor ACSL4

Disorders & Mutationsfor ACSL4

Medical Newsfor ACSL4

Publicationsfor ACSL4

Search for ACSL4

Genome Databases showing ACSL4

Other Databases showing ACSL4

Specialized Databases showing ACSL4

Licensable Technologiesfor ACSL4

Servicesfor ACSL4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACSL4

Summaries
for ACSL4

Genomic Location
for ACSL4

Proteins
for ACSL4

Protein Domains/
Families
for ACSL4

Gene Function
for ACSL4

Pathways & Interactions
for ACSL4

Drugs & Compounds
for ACSL4

Transcripts
for ACSL4

Expression
for ACSL4

Orthologs
for ACSL4

Paralogs
for ACSL4

SNPs/Variants
for ACSL4

Disorders & Mutations
for ACSL4

Medical News
for ACSL4

Publications
for ACSL4

Licensable Technologies
for ACSL4

Services
for ACSL4