Aliases for ACSL3 Gene
Aliases for ACSL3 Gene
External Ids for ACSL3 Gene
- HGNC: 3570
- Entrez Gene: 2181
- Ensembl: ENSG00000123983
- OMIM: 602371
- UniProtKB: O95573
Previous HGNC Symbols for ACSL3 Gene
- FACL3
Previous GeneCards Identifiers for ACSL3 Gene
- GC02P223968
- GC02P223551
- GC02P223433
- GC02P223725
- GC02P215580
Summaries for ACSL3 Gene
-
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACSL3 Gene
ACSL3 (Acyl-CoA Synthetase Long-Chain Family Member 3) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Peroxisome. GO annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.
UniProtKB/Swiss-Prot for ACSL3 Gene
-
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL3 Gene
Genomics for ACSL3 Gene
Regulatory Elements for ACSL3 Gene
- Transcription factor binding sites by QIAGEN in the ACSL3 gene promoter:
Regulatory Element Products
Genomic Location for ACSL3 Gene
- Chromosome:
- 2
- Start:
- 222,860,934 bp from pter
- End:
- 222,944,639 bp from pter
- Size:
- 83,706 bases
- Orientation:
- Plus strand
Genomic View for ACSL3 Gene
- Cytogenetic band:
-
- 2q36.1 by Ensembl
- 2q36.1 by Entrez Gene
- 2q36.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACSL3 Gene
Proteins for ACSL3 Gene
-
Protein details for ACSL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95573-ACSL3_HUMAN
- Recommended name:
- Long-chain-fatty-acid--CoA ligase 3
- Protein Accession:
- O95573
- Q60I92
- Q8IUM9
Protein attributes for ACSL3 Gene
- Size:
- 720 amino acids
- Molecular mass:
- 80420 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
- No Data Available
Protein Expression for ACSL3 Gene
Selected DME Specific Peptides for ACSL3 Gene
- O95573:
-
- GCRIGYSSP
- CGGAPLS
- YIGYLPLAHVLEL
- IAIFCETRAEWMIAAQ
- LGKVEAALKN
- TGRVGAPL
- IIDRKKDLVKLQAGEYV
- LKIIDRKK
- DQSSKIKKGSKGD
Post-translational modifications for ACSL3 Gene
Other Protein References for ACSL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACSL3
- Novus Biologicals Antibodies for ACSL3
- Invitrogen Antibodies for ACSL3
- antibodies-online Antibodies for ACSL3: See all 61
- GeneTex ACSL3 antibody for ACSL3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ACSL3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ACSL3
- Origene Custom Protein Services for ACSL3
- antibodies-online Proteins for ACSL3: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ACSL3
Assay Products
Domains & Families for ACSL3 Gene
Gene Families for ACSL3 Gene
Protein Domains for ACSL3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACSL3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95573- Family:
-
- Belongs to the ATP-dependent AMP-binding enzyme family.
Function for ACSL3 Gene
Molecular function for ACSL3 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
- UniProtKB/Swiss-Prot Function:
- Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
Enzyme Numbers (IUBMB) for ACSL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004467 | long-chain fatty acid-CoA ligase activity | TAS | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016874 | ligase activity | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 20605918 |
Phenotypes for ACSL3 Gene
- MGI mutant phenotypes for ACSL3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ACSL3:
Animal Model Products
-
Taconic Biosciences Mouse Models for ACSL3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACSL3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ACSL3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACSL3 gene
- Search ViGene Biosciences for ACSL3
CRISPR Products
-
OriGene CRISPR knockouts for ACSL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACSL3
- GenScript: Design CRISPR guide RNA sequences for ACSL3
miRNA for ACSL3 Gene
- miRTarBase miRNAs that target ACSL3
-
- hsa-mir-335-5p (MIRT017614)
- hsa-mir-340-5p (MIRT019639)
- hsa-mir-375 (MIRT019874)
- hsa-mir-221-3p (MIRT024182)
- hsa-mir-100-5p (MIRT048455)
- hsa-mir-377-5p (MIRT441287)
- hsa-mir-6086 (MIRT446291)
- hsa-mir-655-5p (MIRT446292)
- hsa-mir-96-3p (MIRT446293)
- hsa-mir-329-5p (MIRT446294)
- hsa-mir-551b-5p (MIRT446295)
- hsa-mir-5582-3p (MIRT446296)
- hsa-mir-548x-3p (MIRT446297)
- hsa-mir-548j-3p (MIRT446298)
- hsa-mir-548aq-3p (MIRT446299)
- hsa-mir-548am-3p (MIRT446300)
- hsa-mir-548aj-3p (MIRT446301)
- hsa-mir-548ah-3p (MIRT446302)
- hsa-mir-548ae-3p (MIRT446303)
- hsa-mir-548z (MIRT446304)
- hsa-mir-548h-3p (MIRT446305)
- hsa-mir-548d-3p (MIRT446306)
- hsa-mir-548bb-3p (MIRT446307)
- hsa-mir-548ac (MIRT446308)
- hsa-mir-26b-5p (MIRT728395)
- hsa-mir-26a-5p (MIRT728396)
miRNA Products
- Search ViGene Biosciences for ACSL3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ACSL3
- Browse OriGene Inhibitory RNA Products For ACSL3
-
ViGene Biosciences ready-to-package AAV shRNAs for ACSL3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACSL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ACSL3
-
ViGene Biosciences adenoviral particle packaged cDNA for ACSL3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ACSL3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACSL3 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSL3 Gene
Localization for ACSL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACSL3 Gene
- Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IEA | -- |
| GO:0005777 | peroxisome | IEA | -- |
| GO:0005778 | peroxisomal membrane | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IDA,IEA | 14741744 |
Pathways & Interactions for ACSL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fatty Acyl-CoA Biosynthesis | ||
| 2 | fatty acid beta-oxidation (peroxisome) | ||
| 3 | Metabolism |
.37
|
|
| 4 | Fatty acid metabolism | ||
| 5 | Mitochondrial LC-Fatty Acid Beta-Oxidation | ||
Pathways by source for ACSL3 Gene
9 BioSystems pathways for ACSL3 Gene
8 KEGG pathways for ACSL3 Gene
Interacting Proteins for ACSL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001676 | long-chain fatty acid metabolic process | IEA | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006633 | fatty acid biosynthetic process | IEA | -- |
| GO:0007420 | brain development | IEA | -- |
No data available for SIGNOR curated interactions for ACSL3 Gene
Drugs & Compounds for ACSL3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Icosapent | Approved | Nutra | Target, inducer | Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation | 0 | |
| Phosphoric acid | Approved | Pharma | 0 | |||
| Adenosine monophosphate | Approved | Nutra | 0 | |||
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| Palmitic Acid | Experimental | Pharma | Full agonist, Agonist | 22 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (2E)-Decenoyl-CoA |
|
10018-95-8 |
|
|||
| (2E)-Dodecenoyl-CoA |
|
1066-12-2 |
|
|||
| (2E)-Hexadecenoyl-CoA |
|
4460-95-1 |
|
|||
| (2E)-Octenoyl-CoA |
|
10018-94-7 |
|
|||
| (2E)-Tetradecenoyl-CoA |
|
38795-33-4 |
|
Transcripts for ACSL3 Gene
mRNA/cDNA for ACSL3 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (379) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ACSL3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ACSL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACSL3
- GenScript: Design CRISPR guide RNA sequences for ACSL3
miRNA Products
- Search ViGene Biosciences for ACSL3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ACSL3
- Browse OriGene Inhibitory RNA Products For ACSL3
-
ViGene Biosciences ready-to-package AAV shRNAs for ACSL3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACSL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | - | - | |||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: |
Expression for ACSL3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACSL3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ACSL3 Gene:
ACSL3SOURCE GeneReport for Unigene cluster for ACSL3 Gene:
Hs.655772Evidence on tissue expression from TISSUES for ACSL3 Gene
- Nervous system(4.6)
- Pancreas(4.3)
- Liver(2.8)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for ACSL3
-
OriGene qPCR primer pairs and template standards for ACSL3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACSL3 Gene
Orthologs for ACSL3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACSL3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ACSL3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ACSL3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Acsl3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Acsl3 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ACSL3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACSL3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ACSL3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ACSL3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | acsl4 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33876 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | acsl3a 35 |
|
OneToMany | |
| acsl3b 34 35 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Acsl 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003623 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | acs-17 35 |
|
ManyToMany | |
| acs-4 35 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FAA1 35 |
|
ManyToMany | |
| FAA3 35 37 |
|
ManyToMany | |||
| FAA4 35 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | LACS8 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0317200 34 |
|
||
| Os.7310 34 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.7413 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.8032 34 |
|
- Species where no ortholog for ACSL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for ACSL3 Gene
(6) SIMAP similar genes for ACSL3 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for ACSL3 Gene
Variants for ACSL3 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000016553 | -- | 222,898,368(+) | CTTAC(C/T)AGATA | intron-variant | |
| rs1000024308 | -- | 222,862,087(+) | ATGGA(A/C)GCTAG | intron-variant | |
| rs1000031438 | -- | 222,889,163(+) | AATTA(A/C)TGTTG | intron-variant | |
| rs1000071562 | -- | 222,870,660(+) | ATTCC(A/T)GGTAG | intron-variant | |
| rs1000129745 | -- | 222,928,313(+) | TGGTG(A/T)TACAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv109n73 | CNV | deletion | 24416366 |
| dgv2156n106 | CNV | deletion | 24896259 |
| esv1240242 | CNV | deletion | 17803354 |
| esv1617678 | CNV | deletion | 17803354 |
| esv2151193 | CNV | deletion | 18987734 |
| esv2621841 | CNV | deletion | 19546169 |
| esv2652841 | CNV | deletion | 19546169 |
| esv2721520 | CNV | deletion | 23290073 |
| esv2721521 | CNV | deletion | 23290073 |
| esv2838902 | CNV | deletion | 24192839 |
| esv3561055 | CNV | deletion | 23714750 |
| esv3561056 | CNV | deletion | 23714750 |
| esv3575333 | CNV | gain | 25503493 |
| esv3584363 | CNV | loss | 25503493 |
| esv3594432 | CNV | loss | 21293372 |
| esv3725 | CNV | loss | 18987735 |
| esv4072 | CNV | loss | 18987735 |
| esv9602 | CNV | loss | 19470904 |
| esv997784 | CNV | deletion | 20482838 |
| nsv1011830 | CNV | gain | 25217958 |
| nsv1072498 | CNV | deletion | 25765185 |
| nsv1116829 | CNV | deletion | 24896259 |
| nsv1151451 | CNV | deletion | 26484159 |
| nsv215259 | CNV | deletion | 16902084 |
| nsv3181 | CNV | deletion | 18451855 |
| nsv435722 | CNV | deletion | 17901297 |
| nsv436299 | CNV | deletion | 17901297 |
| nsv511839 | CNV | loss | 21212237 |
| nsv819092 | CNV | loss | 19587683 |
| nsv954182 | CNV | deletion | 24416366 |
Relevant External Links for ACSL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACSL3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL3 Gene
Disorders for ACSL3 Gene
Relevant External Links for ACSL3
No disorders were found for ACSL3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSL3 Gene
Publications for ACSL3 Gene
- Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PMID: 18003621) Yao H. … Ye J. (J. Biol. Chem. 2008) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PMID: 15556626) Qiao S. … Tuohimaa P. (FEBS Lett. 2004) 3 22 64
- Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PMID: 11707336) Minekura H. … Yamamoto T.T. (Gene 2001) 3 4 64
- Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. (PMID: 9177793) Minekura H. … Yamamoto T.T. (Genomics 1997) 3 4 64
Products for ACSL3 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Browse Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for ACSL3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ACSL3
- Origene Custom Protein Services for ACSL3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ACSL3
- Browse OriGene Inhibitory RNA Products For ACSL3
- OriGene qPCR primer pairs and template standards for ACSL3
- OriGene qPCR primer pairs for ACSL3
- OriGene CRISPR knockouts for ACSL3
- OriGene ORF clones in human for ACSL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ACSL3
- GenScript: Next-day shipping cDNA ORF clone for ACSL3 in any vector
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- GenScript Custom Assay Services for ACSL3
- GenScript Custom overexpressing Cell Line Services for ACSL3
- GenScript: Design CRISPR guide RNA sequences for ACSL3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ACSL3
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ACSL3
- Novus Biologicals proteins and lysates for ACSL3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for ACSL3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for ACSL3: See all 61
- Search antibodies-online for kits
- antibodies-online Proteins for ACSL3: See all 7
- Search antibodies-online for peptides
- GeneTex ACSL3 antibody for ACSL3
- Search GeneTex for Proteins for ACSL3
- ViGene Biosciences adenoviral particle packaged cDNA for ACSL3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ACSL3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ACSL3 gene
- Search ViGene Biosciences for ACSL3
- Santa Cruz Biotechnology (SCBT) Antibodies for ACSL3
- Search Santa Cruz Biotechnology (SCBT) for ACSL3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ACSL3
- Horizon Cell Lines for ACSL3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACSL3
- VectorBuilder custom plasmid, inducible vectors for ACSL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSL3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ACSL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




