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Aliases & Descriptions for ACSL3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ACS3 1 , 2 , 3 , 5 EC 6.2.1.3 3 FACL3 2 , 3 , 5 LACS3 3 OTTHUMP00000164212 2 PRO2194 1 , 2
Descriptions LACS 3 3 Long-chain acyl-CoA synthetase 3 3 acyl-CoA synthetase long-chain family member 3 2 fatty-acid-Coenzyme A ligase, long-chain 3 1 , 2 lignoceroyl-CoA synthase 2
Search outside databases for aliases for ACSL3 genePrevious GC identifers: GC02P223968 GC02P223551
Summaries for ACSL3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ACSL3 : The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligasefamily. Although differing in substrate specificity, subcellular localization, and tissuedistribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoAesters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozymeis highly expressed in brain, and preferentially utilizes myristate, arachidonate, andeicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to thatof rat homolog. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq] UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573 Function : Activation of long-chain fatty acids for both synthesis of cellular lipids, anddegradation via beta-oxidation. Preferentially uses myristate, laurate, arachidonate andeicosapentaenoate as substrates (By similarity)
Gene Wiki entry for ACSL3
Genomic Location for ACSL3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ACSL3 gene Entrez Gene cytogenetic band: 2q34-q35 Ensembl cytogenetic band: 2q36.1 HGNC cytogenetic band: 2q34-q35 ACSL3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P223433:
(about GC identifiers )
Start:
223,433,976 bp from pter
End:
223,516,363 bp from pter
Size:
82,388 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000002.10 NT_005403.16 Proteins for ACSL3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573 (See
protein sequence )Recommended Name: Long-chain-fatty-acid--CoA ligase 3 Size : 720 amino acids; 80420 Da
Cofactor : Magnesium (By similarity)
Subcellular location : Mitochondrion outer membrane; Single-pass type III membrane protein (Bysimilarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsomemembrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane;Single-pass type III membrane protein (By similarity)
Secondary accessions : Q60I92 Q8IUM9
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_004448.2 NP_976251.1 ENSEMBL proteins: ENSP00000350012 ENSP00000375918 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9
):
About this table Antibodies for ACSL3: Assays for ACSL3:
Protein
Domains/ Families for ACSL3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O95573 ProtoNet protein and cluster: O95573
1 Blocks protein family : IPB000873 AMP-binding signature UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573 Similarity : Belongs to the ATP-dependent AMP-binding enzyme family
Gene Function for ACSL3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_004457 Applied Biosystems Silencer ® siRNAs for ACSL3 Sigma-Aldrich siRNA for ACSL3 Sigma-Aldrich shRNA for ACSL3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004457                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004457                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_004457  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004457 UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573 Function : Activation of long-chain fatty acids for both synthesis of cellular lipids, anddegradation via beta-oxidation. Preferentially uses myristate, laurate, arachidonate andeicosapentaenoate as substrates (By similarity) Catalytic activity : ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoAEnzyme Number (IUBMB): EC 6.2.1.3
1 MGI phenotypic allele for Acsl3 (no phenotypes)5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for ACSL3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for ACSL3 (Your Favorite Gene powered by Ingenuity) (see all 7
) Gene Network CentralTM Interacting Genes and Proteins Network for ACSL3 5/29 Interacting proteins for ACSL3 (ENSP00000350012 3 O95573 1 ) via UniProtKB, MINT, and/or STRING (see all 29
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006629 lipid metabolic process
IEA -- GO:0006631 fatty acid metabolic process
IEA -- GO:0008152 metabolic process
IEA --
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Drugs & Compounds for ACSL3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for ACSL3
Browse Tocris compounds for ACSL3
Transcripts for ACSL3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_004457 Sigma-Aldrich siRNA for ACSL3 Sigma-Aldrich shRNA for ACSL3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004457 NM_203372
REFSEQ mRNAs for ACSL3 gene (2 alternative transcripts): NM_004457.3 NM_203372.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004457 NM_203372
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004457                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004457                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_004457  
Additional cDNA sequence: AB061712.1 AF116690.1 AK001471.1 AK023191.1 AK314621.1 BC012066.1 BC032144.2 BC041692.1 CR592887.1 CR608706.1 D89053.1
19 DOTS entries : DT.99962976 DT.217723 DT.100813456 DT.70100809 DT.40109136 DT.91767570 DT.100813459 DT.120939750 DT.405782 DT.422577 DT.91767544 DT.100813468 DT.120939718 DT.100813460 DT.120939704 DT.75196322 DT.91767545 DT.95316984 DT.95293549
24/379 AceView cDNA sequences (see all 379
):AU130030 BX102306 N76698 BQ189105 BQ644588 AU139651 AL119851 CR626202 BU684792 BC032144 AW473591 BQ082616 AU121354 BG111778 AI989323 AI351449 CR604798 AA781480 BX088954 AW028979 BM705776 AA235227 CB149552 BM472141
highest scoring ESTs for ACSL3 :D89053 AA015802 AA148851 AA191465 AA352088 AA644297 AA782253 AA812279 AA854273 AA857937
Unigene Cluster for ACSL3: Acyl-CoA synthetase long-chain family member 3 Hs.655772 [show with all ESTs ] Unigene Representative Sequence: NM_004457 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 (see all 12
) ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ SP1 :           -   -   -   -                                     SP2 :           -   -   -   -     -                 -                 SP3 :                                                     SP4 :           -   -   -   -   -       -   -   -   -   -   -   -   -   -   -   -   -   -   -   SP5 :           -   -   -   -       -   -   -   -   -   -   -   -   -   -   -   -   -   -    
ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 SP1 :               SP2 :               SP3 :               SP4 : -   -             SP5 :              
About this scheme ECgene alternative splicing isoforms for ACSL3 2 Ensembl transcripts including schematic representations : ENST00000357430
ENST00000392066
Expression for ACSL3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ACSL3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ACSL3 1 / 2 / 3
5 probe-sets matching ACSL3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCAGACTAGTSOURCE GeneReport for Unigene cluster: Hs.655772 Expression variation in blood from EXPOLDB for ACSL3
Orthologs for ACSL3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ACSL3 gene from 5/14 species (see all 14
)
About this table Species with no ortholog for ACSL3 ENSEMBL Gene Tree for ACSL3 Paralogs for ACSL3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ACSL3 gene ACSL4 2
SNPs/Variants for ACSL3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ACSL3 (up to first 250kb)
Disorders & Mutations for ACSL3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 602371
Medical News for ACSL3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ACSL3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/22 PubMed articles for ACSL3 gene (see all 22
):
Search for ACSL3
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ACSL3
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ACSL3
(According to HUGE )
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Specialized Databases showing ACSL3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ACSL3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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