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Aliases for ACSL3 Gene

Aliases for ACSL3 Gene

  • Acyl-CoA Synthetase Long-Chain Family Member 3 2 3 5
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 3 2 3
  • Long-Chain Acyl-CoA Synthetase 3 3 4
  • EC 6.2.1.3 4 61
  • LACS 3 3 4
  • FACL3 3 4
  • ACS3 3 4
  • Long-Chain-Fatty-Acid--CoA Ligase 3 3
  • Lignoceroyl-CoA Synthase 3
  • PRO2194 3
  • LACS3 4

External Ids for ACSL3 Gene

Previous HGNC Symbols for ACSL3 Gene

  • FACL3

Previous GeneCards Identifiers for ACSL3 Gene

  • GC02P223968
  • GC02P223551
  • GC02P223433
  • GC02P223725
  • GC02P215580

Summaries for ACSL3 Gene

Entrez Gene Summary for ACSL3 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACSL3 Gene

ACSL3 (Acyl-CoA Synthetase Long-Chain Family Member 3) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.

UniProtKB/Swiss-Prot for ACSL3 Gene

  • Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).

Gene Wiki entry for ACSL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL3 Gene

Genomics for ACSL3 Gene

Regulatory Elements for ACSL3 Gene

Enhancers for ACSL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F222805 0.8 FANTOM5 Ensembl ENCODE 15.2 -54.5 -54514 2.0 ZFP64 ARID4B ZNF48 ELK1 KAT8 ATF4 ETV4 KDM1A LEF1 ZNF792 ACSL3 ENSG00000203531 LOC105373904 LOC105373903
GH02F222837 1 Ensembl ENCODE 11.9 -22.7 -22715 2.3 PKNOX1 JUN ZNF384 FEZF1 ZNF316 GATA3 CTBP1 ZNF366 ZNF600 FOS ACSL3 LOC105373904 LOC105373903
GH02F222707 0.8 Ensembl ENCODE 11.7 -152.2 -152223 3.4 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ACSL3 MOGAT1 LOC105373904 FARSB RPL31P17 ENSG00000203531
GH02F222706 0.6 ENCODE 11.7 -154.1 -154128 0.3 ACSL3 MOGAT1 LOC105373904 FARSB ENSG00000203531 RPL31P17
GH02F222891 0.4 Ensembl 11.6 +32.0 31967 2.2 JUN CEBPB CEBPG EP300 ATF2 NR2F2 HIC1 ZNF664 ZNF366 CEBPA ACSL3 LOC105373904 ENSG00000203531 GC02M222904 GC02M222847
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ACSL3 on UCSC Golden Path with GeneCards custom track

Promoters for ACSL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000608187 766 2601 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143

Genomic Location for ACSL3 Gene

Chromosome:
2
Start:
222,860,934 bp from pter
End:
222,944,639 bp from pter
Size:
83,706 bases
Orientation:
Plus strand

Genomic View for ACSL3 Gene

Genes around ACSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL3 Gene

Proteins for ACSL3 Gene

  • Protein details for ACSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95573-ACSL3_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 3
    Protein Accession:
    O95573
    Secondary Accessions:
    • Q60I92
    • Q8IUM9

    Protein attributes for ACSL3 Gene

    Size:
    720 amino acids
    Molecular mass:
    80420 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for ACSL3 Gene

Post-translational modifications for ACSL3 Gene

  • Ubiquitination at Lys 679
  • Modification sites at PhosphoSitePlus

Other Protein References for ACSL3 Gene

Domains & Families for ACSL3 Gene

Gene Families for ACSL3 Gene

Protein Domains for ACSL3 Gene

Suggested Antigen Peptide Sequences for ACSL3 Gene

Graphical View of Domain Structure for InterPro Entry

O95573

UniProtKB/Swiss-Prot:

ACSL3_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSL3: view

Function for ACSL3 Gene

Molecular function for ACSL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
UniProtKB/Swiss-Prot Function:
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).

Enzyme Numbers (IUBMB) for ACSL3 Gene

Gene Ontology (GO) - Molecular Function for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004467 long-chain fatty acid-CoA ligase activity IMP,TAS --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0019901 protein kinase binding IPI 20605918
genes like me logo Genes that share ontologies with ACSL3: view
genes like me logo Genes that share phenotypes with ACSL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACSL3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSL3 Gene

Localization for ACSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL3 Gene

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSL3 Gene COMPARTMENTS Subcellular localization image for ACSL3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
peroxisome 5
mitochondrion 4
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0005783 endoplasmic reticulum IEA,IDA 14741744
genes like me logo Genes that share ontologies with ACSL3: view

Pathways & Interactions for ACSL3 Gene

genes like me logo Genes that share pathways with ACSL3: view

Gene Ontology (GO) - Biological Process for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with ACSL3: view

No data available for SIGNOR curated interactions for ACSL3 Gene

Drugs & Compounds for ACSL3 Gene

(8) Drugs for ACSL3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icosapent Approved Nutra Target, inducer Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(33) Additional Compounds for ACSL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSL3: view

Transcripts for ACSL3 Gene

Unigene Clusters for ACSL3 Gene

Acyl-CoA synthetase long-chain family member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: -
SP7:
SP8: -
SP9: -
SP10: -
SP11: - - - - - -
SP12:

ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ACSL3 Gene

GeneLoc Exon Structure for
ACSL3
ECgene alternative splicing isoforms for
ACSL3

Expression for ACSL3 Gene

mRNA expression in normal human tissues for ACSL3 Gene

Protein differential expression in normal tissues from HIPED for ACSL3 Gene

This gene is overexpressed in Nasal epithelium (7.9) and Retina (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACSL3 Gene



Protein tissue co-expression partners for ACSL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACSL3 Gene:

ACSL3

SOURCE GeneReport for Unigene cluster for ACSL3 Gene:

Hs.655772
genes like me logo Genes that share expression patterns with ACSL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACSL3 Gene

Orthologs for ACSL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSL3 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia ACSL3 34 35
  • 92.22 (n)
dog
(Canis familiaris)
Mammalia ACSL3 34 35
  • 90.83 (n)
mouse
(Mus musculus)
Mammalia Acsl3 34 16 35
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Acsl3 34
  • 88.06 (n)
oppossum
(Monodelphis domestica)
Mammalia ACSL3 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACSL3 34 35
  • 79.02 (n)
lizard
(Anolis carolinensis)
Reptilia ACSL3 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl4 34
  • 68.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33876 34
zebrafish
(Danio rerio)
Actinopterygii acsl3a 35
  • 69 (a)
OneToMany
acsl3b 34 35
  • 66.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Acsl 34 35
  • 52.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003623 34
  • 51.7 (n)
worm
(Caenorhabditis elegans)
Secernentea acs-17 35
  • 44 (a)
ManyToMany
acs-4 35
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA1 35
  • 30 (a)
ManyToMany
FAA3 35 37
  • 30 (a)
ManyToMany
FAA4 35
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LACS8 34
  • 54.37 (n)
rice
(Oryza sativa)
Liliopsida Os05g0317200 34
  • 54.45 (n)
Os.7310 34
wheat
(Triticum aestivum)
Liliopsida Ta.7413 34
corn
(Zea mays)
Liliopsida Zm.8032 34
Species where no ortholog for ACSL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACSL3 Gene

ENSEMBL:
Gene Tree for ACSL3 (if available)
TreeFam:
Gene Tree for ACSL3 (if available)

Paralogs for ACSL3 Gene

Paralogs for ACSL3 Gene

(6) SIMAP similar genes for ACSL3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ACSL3 Gene

genes like me logo Genes that share paralogs with ACSL3: view

Variants for ACSL3 Gene

Sequence variations from dbSNP and Humsavar for ACSL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1011965 -- 222,886,789(+) tacag(A/C)aaaat intron-variant
rs1014280 -- 222,941,256(+) AATAT(A/G)TATTC intron-variant
rs10169861 -- 222,871,160(+) GGGCA(A/G)GGGAA intron-variant
rs10172473 -- 222,914,402(+) GGGAC(A/G)ACAGG intron-variant
rs10174348 -- 222,911,056(+) TTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSL3 Gene

Variant ID Type Subtype PubMed ID
dgv109n73 CNV deletion 24416366
dgv2156n106 CNV deletion 24896259
esv1240242 CNV deletion 17803354
esv1617678 CNV deletion 17803354
esv2151193 CNV deletion 18987734
esv2621841 CNV deletion 19546169
esv2652841 CNV deletion 19546169
esv2721520 CNV deletion 23290073
esv2721521 CNV deletion 23290073
esv2838902 CNV deletion 24192839
esv3561055 CNV deletion 23714750
esv3561056 CNV deletion 23714750
esv3575333 CNV gain 25503493
esv3584363 CNV loss 25503493
esv3594432 CNV loss 21293372
esv3725 CNV loss 18987735
esv4072 CNV loss 18987735
esv9602 CNV loss 19470904
esv997784 CNV deletion 20482838
nsv1011830 CNV gain 25217958
nsv1072498 CNV deletion 25765185
nsv1116829 CNV deletion 24896259
nsv1151451 CNV deletion 26484159
nsv215259 CNV deletion 16902084
nsv3181 CNV deletion 18451855
nsv435722 CNV deletion 17901297
nsv436299 CNV deletion 17901297
nsv511839 CNV loss 21212237
nsv819092 CNV loss 19587683
nsv954182 CNV deletion 24416366

Variation tolerance for ACSL3 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACSL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL3 Gene

Disorders for ACSL3 Gene

Relevant External Links for ACSL3

Genetic Association Database (GAD)
ACSL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACSL3

No disorders were found for ACSL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSL3 Gene

Publications for ACSL3 Gene

  1. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PMID: 18003621) Yao H. … Ye J. (J. Biol. Chem. 2008) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PMID: 15556626) Qiao S. … Tuohimaa P. (FEBS Lett. 2004) 3 22 64
  4. Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PMID: 11707336) Minekura H. … Yamamoto T.T. (Gene 2001) 3 4 64
  5. Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. (PMID: 9177793) Minekura H. … Yamamoto T.T. (Genomics 1997) 3 4 64

Products for ACSL3 Gene

Sources for ACSL3 Gene

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