Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ACSL3 Gene

protein-coding   GIFtS: 64
GCID: GC02P223725

Acyl-CoA Synthetase Long-Chain Family Member 3

(Previous names: fatty-acid-Coenzyme A ligase, long-chain 3)
(Previous symbol: FACL3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Acyl-CoA Synthetase Long-Chain Family Member 31 2     EC 6.2.1.33 8
FACL31 2 3 5     PRO21942
ACS32 3 5     Lignoceroyl-CoA Synthase2
Fatty-Acid-Coenzyme A Ligase, Long-Chain 31 2     Long-Chain-Fatty-Acid--CoA Ligase 32
Long-Chain Acyl-CoA Synthetase 32 3     LACS33
LACS 32 3     

External Ids:    HGNC: 35701   Entrez Gene: 21812   Ensembl: ENSG000001239837   OMIM: 6023715   UniProtKB: O955733   

Export aliases for ACSL3 gene to outside databases

Previous GC identifers: GC02P223968 GC02P223551 GC02P223433 GC02P215580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ACSL3 Gene:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although
differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this
family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid
biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes
myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92%
identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACSL3 Gene:
ACSL3 (acyl-CoA synthetase long-chain family member 3) is a protein-coding gene. Diseases associated with ACSL3 include saethre-chotzen syndrome, and craniosynostosis. GO annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573
Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and
degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses
myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role
in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major
phospholipid located on the surface of VLDL (very low density lipoproteins)

Gene Wiki entry for ACSL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACSL3 gene promoter:
         Pax-2a   AP-4   CBF-C   HNF-4alpha1   CBF-A   CBF-B   CP1C   CP1A   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ACSL3 promoter sequence
   Search Chromatin IP Primers for ACSL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACSL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34-q35   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q34-q35

ACSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSL3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223725:  view genomic region     (about GC identifiers)

Start:
223,725,652 bp from pter      End:
223,809,357 bp from pter
Size:
83,706 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573 (See protein sequence)
Recommended Name: Long-chain-fatty-acid--CoA ligase 3  
Size: 720 amino acids; 80420 Da
Cofactor: Magnesium (By similarity)
Secondary accessions: Q60I92 Q8IUM9

Explore the universe of human proteins at neXtProt for ACSL3: NX_O95573

Explore proteomics data for ACSL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys679
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACSL3 (O95573) (see all 9)
     CGGAPLS  TGRVGAPL  LKIIDRKK  GCRIGYSSP 


    See ACSL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004448.2  NP_976251.1  

    ENSEMBL proteins: 
     ENSP00000350012   ENSP00000375918   ENSP00000438342   ENSP00000416913   ENSP00000441643  
     ENSP00000404182   ENSP00000385157  
    Reactome Protein details: O95573

    ACSL3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ACSL3
    OriGene Protein Over-expression Lysate for ACSL3
    OriGene MassSpec for ACSL3
    OriGene Custom Protein Services for ACSL3
    GenScript Custom Purified and Recombinant Proteins Services for ACSL3
    Novus Biologicals ACSL3 Proteins
    Novus Biologicals ACSL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACSL3

    ACSL3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACSL3
    OriGene Custom Antibody Services for ACSL3
    Novus Biologicals ACSL3 Antibodies
    Abcam antibodies for ACSL3
    Cloud-Clone Corp. Antibodies for ACSL3
    ThermoFisher Antibodies for ACSL3
    LSBio Antibodies in human, mouse, rat for ACSL3

    ACSL3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACSL3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACSL3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACSL3
    Cloud-Clone Corp. CLIAs for ACSL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ACS: Acyl-CoA synthetase family

    2 InterPro protein domains:
     IPR020845 AMP-binding_CS
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry O95573

    ProtoNet protein and cluster: O95573

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    ACSL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACSL3_HUMAN, O95573
    Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and
    degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses
    myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role
    in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major
    phospholipid located on the surface of VLDL (very low density lipoproteins)
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA

         Enzyme Number (IUBMB): EC 6.2.1.31 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IMP--
    GO:0005524ATP binding IEA--
    GO:0019901protein kinase binding IPI--
    GO:0019904protein domain specific binding IPI--
         
    ACSL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACSL3:
     Increased cilium length after  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acsl3):
     growth/size/body  hematopoietic system  immune system 

    ACSL3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACSL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACSL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACSL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACSL3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACSL3:
    hsa-mir-100-5p (MIRT048455), hsa-mir-340-5p (MIRT019639), hsa-mir-375 (MIRT019874), hsa-mir-335-5p (MIRT017614), hsa-mir-221-3p (MIRT024182)

    Block miRNA regulation of human, mouse, rat ACSL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACSL3 (see all 70):
    hsa-miR-548j hsa-miR-642a hsa-miR-300 hsa-miR-188-5p hsa-miR-371-5p hsa-miR-550a* hsa-miR-548a-5p hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidACSL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACSL3
    Predesigned siRNA for gene silencing in human, mouse, rat ACSL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACSL3

    Clone
    Products:
         
    OriGene clones in human, mouse for ACSL3 (see all 12)
    OriGene ORF clones in mouse, rat for ACSL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACSL3 (NM_004457)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACSL3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACSL3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ACSL3_HUMAN, O95573: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity).
    Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type
    III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    mitochondrion5
    peroxisome5
    cytosol1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005778peroxisomal membrane IEA--
    GO:0005783endoplasmic reticulum IDA14741744
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IDA--

    ACSL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ACSL3 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    2PPAR signaling pathway
    fatty acid beta-oxidation VI (peroxisome)0.00
    PPAR signaling pathway
    3stearate biosynthesis I (animals)
    stearate biosynthesis I (animals)0.35
    eicosapentaenoate biosynthesis II (metazoa)0.00
    gamma-linolenate biosynthesis II (animals)0.35
    fatty acid activation0.00
    fatty acid beta-oxidation I0.30
    4Triglyceride Biosynthesis
    Triglyceride Biosynthesis
    Fatty Acyl-CoA Biosynthesis0.00
    Synthesis of very long-chain fatty acyl-CoAs0.00
    5Fatty acid metabolism
    Fatty acid metabolism0.42
    Fatty acid degradation0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for ACSL3 (see all 9)
        Fatty Acid Beta Oxidation
    stearate biosynthesis I (animals)
    gamma-linolenate biosynthesis II (animals)
    fatty acid beta-oxidation VI (peroxisome)
    fatty acid beta-oxidation I

    1 Reactome Pathway for ACSL3
        Synthesis of very long-chain fatty acyl-CoAs


    Selected Kegg Pathways  (Kegg details for ACSL3) (see all 6):
        Fatty acid degradation
    Metabolic pathways
    Fatty acid metabolism
    PPAR signaling pathway
    Peroxisome


    ACSL3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACSL3: 
              Fatty Acid Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ACSL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACSL3 (O955733 ENSP000003500124) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPG20Q8N0X73, ENSP000003473144I2D: score=2 STRING: ENSP00000347314
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    NDRG1Q925973, ENSP000003199774I2D: score=3 STRING: ENSP00000319977
    DDA1Q9BW613I2D: score=1 
    GBASO753233I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001676long-chain fatty acid metabolic process ----
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0007420brain development IEA--
    GO:0007584response to nutrient IEA--
    GO:0008152metabolic process ----

    ACSL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACSL3

    Selected HMDB Compounds for ACSL3 (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----

    1 DrugBank Compound for ACSL3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IcosapentEicosapentaenoic acid (see all 4)10417-94-4targetinducer17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ACSL3 gene (2 alternative transcripts): 
    NM_004457.3  NM_203372.1  

    Unigene Cluster for ACSL3:

    Acyl-CoA synthetase long-chain family member 3
    Hs.655772  [show with all ESTs]
    Unigene Representative Sequence: NM_004457
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357430(uc002vni.3 uc002vnj.3) ENST00000392066 ENST00000535678
    ENST00000413316 ENST00000542810 ENST00000540115 ENST00000463813 ENST00000421680
    ENST00000407441 ENST00000474422 ENST00000495541
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACSL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACSL3 (see all 70):
    hsa-miR-548j hsa-miR-642a hsa-miR-300 hsa-miR-188-5p hsa-miR-371-5p hsa-miR-550a* hsa-miR-548a-5p hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidACSL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACSL3
    Predesigned siRNA for gene silencing in human, mouse, rat ACSL3
    Clone
    Products:
         
    OriGene clones in human, mouse for ACSL3 (see all 12)
    OriGene ORF clones in mouse, rat for ACSL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACSL3 (NM_004457)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACSL3
    OriGene qSTAR qPCR primer pairs in human, mouse for ACSL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACSL3
      QuantiTect SYBR Green Assays in human, mouse, rat ACSL3
      QuantiFast Probe-based Assays in human, mouse, rat ACSL3

    Additional mRNA sequence: 

    AB061712.1 AF116690.1 AK001471.1 AK023191.1 AK314621.1 BC012066.1 BC032144.2 BC041692.1 
    D89053.1 

    20 DOTS entries:

    DT.99962976  DT.217723  DT.100813456  DT.70100809  DT.40109136  DT.91767570  DT.100813459  DT.120939750 
    DT.91767544  DT.100813468  DT.120939718  DT.405782  DT.100813460  DT.120939687  DT.120939704  DT.75196322 
    DT.91767545  DT.95316984  DT.422577  DT.95293549 

    Selected AceView cDNA sequences (see all 379):

    BC041692 AI811296 AI346013 N76698 CR604798 AI351449 AI989323 BF149141 
    BM705776 AB061712 AW028979 BX102306 CD677145 BX095257 AI340340 AK023191 
    T92314 F03962 AA015802 CR608706 BQ644588 BQ950592 BI089639 BX088954 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^
    SP1:                                -     -     -     -                                                                                                         
    SP2:                                -     -     -     -           -                                               -                                             
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -         

    ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:  -     -                                 
    SP5:                                          


    ECgene alternative splicing isoforms for ACSL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ACSL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGACTAGT
    ACSL3 Expression
    About this image


    ACSL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
    ACSL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACSL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655772
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACSL3: 
              Fatty Acid Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACSL3
    OriGene qSTAR qPCR primer pairs in human, mouse for ACSL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACSL3
    QuantiTect SYBR Green Assays in human, mouse, rat ACSL3
    QuantiFast Probe-based Assays in human, mouse, rat ACSL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACSL3 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acsl31 , 5 acyl-CoA synthetase long-chain family member 31, 5 88.89(n)1
    92.92(a)1
      1 (40.84 cM)5
    742051  NM_028817.31  NP_083093.21 
     786578255 
    chicken
    (Gallus gallus)
    Aves ACSL31 acyl-CoA synthetase long-chain family member 3 79.02(n)
    83.57(a)
      424810  XM_422625.4  XP_422625.3 
    lizard
    (Anolis carolinensis)
    Reptilia ACSL36
    acyl-CoA synthetase long-chain family member 3
    79(a)
    1 ↔ 1
    3(25387268-25422482)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.338762 Xenopus laevis transcribed sequence with moderate similarity more 77.48(n)    BJ624854.1 
    zebrafish
    (Danio rerio)
    Actinopterygii acsl3b1 acyl-CoA synthetase long-chain family member 3b 66.76(n)
    74.61(a)
      559656  NM_001145932.1  NP_001139404.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Acsl1 Acyl-CoA synthetase long-chain 52.6(n)
    50.44(a)
      46068  NM_170615.2  NP_724695.1 
    worm
    (Caenorhabditis elegans)
    Secernentea acs-176
    acs-46
    Protein ACS-4 (acs-4) mRNA, complete cds
    44(a)
    43(a)
    many ↔ many
    many ↔ many
    X(5937565-5942195) WBGene00016716
    III(7167838-7170992) WBGene00018152
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAA3(YIL009W)4 Long chain fatty acyl-CoA synthetase, activates imported more   --   9(339344-341428) 854808  NP_012257.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LACS81 LACS8 54.37(n)
    48.51(a)
      814974  NM_126468.3  NP_178516.1 
    rice
    (Oryza sativa)
    Liliopsida Os.73102 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.88(n)    AK100521.1 


    ENSEMBL Gene Tree for ACSL3 (if available)
    TreeFam Gene Tree for ACSL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ACSL3 gene
    ACSL42  
    6 SIMAP similar genes for ACSL3 using alignment to 7 protein entries:     ACSL3_HUMAN (see all proteins):
    FACL4    ACSL4    ACSL1    ACSL6    ACSL5    FACL5

    ACSL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACSL3
    PGOHUM00000238200


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ACSL3 (see all 1861)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928451321,2
    --223723772(+) ATGTAC/TATTGT 2 -- us2k10--------
    rs1430749831,2
    --223723829(+) TTTTTC/TTTTTT 2 -- us2k10--------
    rs1853455601,2
    --223723906(+) ACCTTC/TGCCTC 2 -- us2k10--------
    rs1901226041,2
    --223723976(+) CACCAA/CGCCTG 2 -- us2k10--------
    rs1822863721,2
    --223724005(+) AGTAGA/CGACAG 2 -- us2k10--------
    rs356444611,2
    C,F--223724047(+) ACTCCC/TGACCT 2 -- us2k13Minor allele frequency- T:0.40NA WA CSA 5
    rs1873955501,2
    --223724062(+) TGATCC/TGCCTG 2 -- us2k10--------
    rs1416413601,2
    --223724233(+) AAGTAA/TCTCTA 2 -- us2k10--------
    rs767357321,2
    C,F--223724273(+) AACAAG/AATGAG 2 -- us2k13Minor allele frequency- A:0.07NA WA 240
    rs1461749691,2
    --223724424(+) AAGGTA/GCAATA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACSL3 (223725652 - 223809357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ACSL3 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3725CNV Deletion18987735
    esv1617678CNV Deletion17803354
    esv1240242CNV Deletion17803354
    nsv436299CNV Deletion17901297
    esv4072CNV Deletion18987735
    esv2721521CNV Deletion23290073
    nsv435722CNV Deletion17901297
    esv997784CNV Deletion20482838
    esv2621841CNV Deletion19546169
    esv2721520CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACSL3
    DNA2.0 Custom Variant and Variant Library Synthesis for ACSL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602371    OMIM disorders: --

    12 diseases for ACSL3:    
    About MalaCards
    saethre-chotzen syndrome    craniosynostosis    hypertriglyceridemia    labyrinthitis
    asthma    tonsillitis    prostate cancer    prostatitis
    cerebritis    hepatitis    thyroiditis    malaria


    ACSL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACSL3

    Export disorders for ACSL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ACSL3 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with ACSL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PubMed id 18003621)1, 2 Yao H. and Ye J. (J. Biol. Chem. 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PubMed id 11707336)1, 2 Minekura H....Yamamoto T.T. (Gene 2001)
    4. Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. (PubMed id 9177793)1, 2 Minekura H.... Yamamoto T.T. (Genomics 1997)
    5. Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PubMed id 15556626)1, 9 Qiao S. and Tuohimaa P. (FEBS Lett. 2004)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles. (PubMed id 23762027)1 Nchoutmboube J.A....Belov G.A. (PLoS Pathog. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2181 HGNC: 3570 AceView: ACSL3 Ensembl:ENSG00000123983 euGenes: HUgn2181
    ECgene: ACSL3 Kegg: 2181 H-InvDB: ACSL3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ACSL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ACSL3 gene:
    Search GeneIP for patents involving ACSL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACSL3   OriGene RNAi products in human, mouse, rat for ACSL3  
     OriGene qPCR primer pairs and template standards for ACSL3   OriGene Protein Over-expression Lysate for ACSL3  
     OriGene MassSpec something-or-other for ACSL3   OriGene clones in human, mouse for ACSL3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACSL3   OriGene Purified Protein for ACSL3  
     OriGene ORF clones in mouse, rat for ACSL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACSL3   OriGene Custom Protein Services for ACSL3  

     
     
     Block miRNA regulation of human, mouse, rat ACSL3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ACSL3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACSL3 Predesigned siRNA for gene silencing in human, mouse, rat ACSL3
     QuantiFast Probe-based Assays in human, mouse, rat ACSL3 QuantiTect SYBR Green Assays in human, mouse, rat ACSL3
     PCR Arrays including human, mouse, rat ACSL3 Search Chromatin IP Primers for ACSL3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACSL3  GeneGlobe Interaction Network for ACSL3
     Regulatory tfbs in ACSL3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ACSL3 GenScript cDNA clones with any tag delivered in your preferred vector for ACSL3
     GenScript Custom Assay Services for ACSL3 GenScript Custom overexpressing Cell Line Services for ACSL3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ACSL3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ACSL3 antibodies
     ACSL3 proteins
     ACSL3 lysates
     Antibodies for ACSL3
     See all of Abcam's Antibodies, Kits and Proteins for ACSL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ACSL3
     Antibodies for ACSL3
     ELISAs for ACSL3
     CLIAs for ACSL3



     Browse ESI BIO Cell Lines and PureStem Progenitors for ACSL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL3
     SwitchGear 3'UTR luciferase reporter plasmids for ACSL3
     SwitchGear Promoter luciferase reporter plasmids for ACSL3
     ThermoFisher Antibodies for ACSL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACSL3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACSL3
     LSBio Antibodies in human, mouse, rat for ACSL3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACSL3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4