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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACSL3 Gene

protein-coding   GIFtS: 60
GCID: GC02P223725

acyl-CoA synthetase long-chain family member 3

(Previous names: fatty-acid-Coenzyme A ligase, long-chain 3 )
(Previous symbol: FACL3)
 Explore 8 diseases affiliated with
ACSL3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ACSL3    

Aliases
for ACSL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Acyl-CoA Synthetase Long-Chain Family Member 31 2     LACS 32 3
ACS31 2 3 5     EC 6.2.1.33 8
FACL31 2 3 5     Lignoceroyl-CoA Synthase2
PRO21941 2     Long-Chain-Fatty-Acid--CoA Ligase 32
Fatty-Acid-Coenzyme A Ligase, Long-Chain 31 2     LACS33
Long-Chain Acyl-CoA Synthetase 32 3     

External Ids:    HGNC: 35701   Entrez Gene: 21812   Ensembl: ENSG000001239837   OMIM: 6023715   UniProtKB: O955733   

Export aliases for ACSL3 gene to outside databases

Previous GC identifers: GC02P223968 GC02P223551 GC02P223433 GC02P215580


Summaries
for ACSL3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ACSL3:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although
differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family
convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and
fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate,
arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of
rat homolog. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573
Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and
degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate,
laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy
metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on
the surface of VLDL (very low density lipoproteins)

Gene Wiki entry for ACSL3


Genomic Views
for ACSL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACSL3 gene promoter:
         Pax-2a   AP-4   CBF-C   HNF-4alpha1   CBF-A   CBF-B   CP1C   CP1A   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ACSL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACSL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34-q35   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q34-q35

ACSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSL3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223725:  view genomic region     (about GC identifiers)

Start:
 223,725,652 bp from pter      End:
 223,809,357 bp from pter
Size:
 83,706 bases      Orientation:
 plus strand

Proteins
for ACSL3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573 (See protein sequence)
Recommended Name: Long-chain-fatty-acid--CoA ligase 3  
Size: 720 amino acids; 80420 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome
membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane
protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity)
Secondary accessions: Q60I92 Q8IUM9

Explore the universe of human proteins at neXtProt for ACSL3: NX_O95573

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95573

    • 4/9 DME Specific Peptides for ACSL3 (O95573) (see all 9)
     CGGAPLS  TGRVGAPL  LKIIDRKK  GCRIGYSSP 

    ACSL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004448.2  NP_976251.1  

    ENSEMBL proteins: 
     ENSP00000350012   ENSP00000375918   ENSP00000438342   ENSP00000416913   ENSP00000441643  
     ENSP00000404182   ENSP00000385157  
    Reactome Protein details: O95573
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins (see all 2): ACSL3
    OriGene Protein Over-expression Lysate (see all 2): ACSL3
    OriGene Custom Protein Services for ACSL3 
    GenScript Custom Purified and Recombinant Proteins Services for ACSL3
    Novus Biologicals ACSL3 Proteins
    Novus Biologicals ACSL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ACSL3

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005778peroxisomal membrane IEA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----


    ACSL3 for ontologies           About GeneDecksing



    ACSL3 Antibody Products: 
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    Uscn Antibodies for ACSL3
    ThermoFisher Antibodies for ACSL3

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    Uscn ELISAs and CLIAs for ACSL3

    Protein Domains /
    Families
    for ACSL3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ACSL3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry O95573

    ProtoNet protein and cluster: O95573

    1 Blocks protein family: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Function
    for ACSL3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573
    Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and
    degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate,
    laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy
    metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on
    the surface of VLDL (very low density lipoproteins)
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA

    Enzyme Number (IUBMB): EC 6.2.1.31 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): ACSL3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSL3
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSL3 (see all 70):
    hsa-miR-548j hsa-miR-642a hsa-miR-300 hsa-miR-188-5p hsa-miR-371-5p hsa-miR-550a* hsa-miR-548a-5p hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmid: ACSL3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACSL3 (see all 7)
    OriGene shRNA RFP: ACSL3
    OriGene siRNA: ACSL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSL3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ACSL3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACSL3 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ACSL3 (NM_004457)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSL3 

    Cell Line
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    Search LifeMap BioReagents cell lines for ACSL3

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IMP--
    GO:0005524ATP binding IEA--
    GO:0019901protein kinase binding IPI--
    GO:0019904protein domain specific binding IPI--


    ACSL3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ACSL3:
     Increased cilium length after  

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Acsl3):
     growth/size  hematopoietic system  immune system 

    ACSL3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ACSL3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1fatty acid alpha-oxidation II
    		fatty acid alpha-oxidation II1.00
    		stearate biosynthesis I (animals)0.43
    		fatty acid activation0.67
    		fatty acid beta-oxidation I0.39
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    3Fatty Acid Beta Oxidation
    		Fatty Acid Beta Oxidation1.00
    		Fatty acid metabolism0.32
    		Mitochondrial LC-Fatty Acid Beta-Oxidation0.35
    4Fatty Acyl-CoA Biosynthesis
    		Fatty Acyl-CoA Biosynthesis1.00
    		Triglyceride Biosynthesis0.47
    		Synthesis of very long-chain fatty acyl-CoAs0.78
    5eicosapentaenoate biosynthesis II (metazoa)
    		eicosapentaenoate biosynthesis II (metazoa)1.00
    		gamma-linolenate biosynthesis II (animals)0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/9 BioSystems Pathways for ACSL3 (see all 9) 
        Fatty Acid Beta Oxidation
    stearate biosynthesis I (animals)
    fatty acid alpha-oxidation II
    fatty acid beta-oxidation I
    gamma-linolenate biosynthesis II (animals)

    5/6        Reactome Pathways for ACSL3 (see all 6)
        Metabolism
    Synthesis of very long-chain fatty acyl-CoAs
    Triglyceride Biosynthesis
    Fatty Acyl-CoA Biosynthesis
    Fatty acid, triacylglycerol, and ketone body metabolism


    5         Kegg Pathways  (Kegg details for ACSL3):
        Fatty acid metabolism
    Metabolic pathways
    PPAR signaling pathway
    Peroxisome
    Adipocytokine signaling pathway


    ACSL3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACSL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for ACSL3 (O955733 ENSP000003500124) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPG20Q8N0X73, ENSP000003473144I2D: score=2 STRING: ENSP00000347314
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    NDRG1Q925973, ENSP000003199774I2D: score=3 STRING: ENSP00000319977
    DDA1Q9BW613I2D: score=1 
    GBASO753233I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0007420brain development IEA--
    GO:0007584response to nutrient IEA--
    GO:0014070response to organic cyclic compound IEA--
    GO:0019432triglyceride biosynthetic process TAS--


    ACSL3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ACSL3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACSL3

    10/41 HMDB Compounds for ACSL3 (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----

    1 DrugBank Compound for ACSL3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IcosapentEicosapentaenoic acid (see all 4)10417-94-4targetinducer17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about ACSL3 

    Transcripts
    for ACSL3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ACSL3 gene (2 alternative transcripts): 
    NM_004457.3  NM_203372.1  

    Unigene Cluster for ACSL3:

    Acyl-CoA synthetase long-chain family member 3
    Hs.655772  [show with all ESTs]
    Unigene Representative Sequence: NM_004457
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357430(uc002vni.3 uc002vnj.3) ENST00000392066 ENST00000535678
    ENST00000413316 ENST00000542810 ENST00000540115 ENST00000463813 ENST00000421680
    ENST00000407441 ENST00000474422 ENST00000495541

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSL3
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSL3 (see all 70):
    hsa-miR-548j hsa-miR-642a hsa-miR-300 hsa-miR-188-5p hsa-miR-371-5p hsa-miR-550a* hsa-miR-548a-5p hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmid: ACSL3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACSL3 (see all 7)
    OriGene shRNA RFP: ACSL3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSL3
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSL3

    Additional cDNA sequence: 

    AB061712.1 AF116690.1 AK001471.1 AK023191.1 AK314621.1 BC012066.1 BC032144.2 BC041692.1 
    D89053.1 

    20 DOTS entries:

    DT.99962976  DT.217723  DT.100813456  DT.70100809  DT.40109136  DT.91767570  DT.100813459  DT.120939750 
    DT.91767544  DT.100813468  DT.120939718  DT.405782  DT.100813460  DT.120939687  DT.120939704  DT.75196322 
    DT.91767545  DT.95316984  DT.422577  DT.95293549 

    24/379 AceView cDNA sequences (see all 379):

    NM_004457 AA812279 AL121263 AB061712 BU618432 CB149552 CD677145 AA235227 
    AA015802 CA454816 BC032144 AI351449 NM_203372 AU153736 AL710872 BF362207 
    BQ189105 BQ644588 BI089639 AU121354 BU684792 AU139651 AI989295 CR626202 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^
    SP1:                                -     -     -     -                                                                                                         
    SP2:                                -     -     -     -           -                                               -                                             
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -         

    ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:  -     -                                 
    SP5:                                          


    ECgene alternative splicing isoforms for ACSL3

    Expression
    for ACSL3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACSL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGACTAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ACSL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACSL3

    SOURCE GeneReport for Unigene cluster: Hs.655772
        SABiosciences Expression via Pathway-Focused PCR Arrays including ACSL3: 
              Fatty Acid Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACSL3
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    In Situ
    Assay Products:     
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    Orthologs
    for ACSL3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACSL3 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ACSL31 acyl-CoA synthetase long-chain family member 3 79.02(n)
    83.57(a)    		   424810  XM_422625.3  XP_422625.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ACSL36
    		 --
    		 79(a)
    		 1 ↔ 1
    		 3(25387277-25420335)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.338762 Xenopus laevis transcribed sequence with moderate similarity more 77.48(n)    BJ624854.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii acsl3b1 acyl-CoA synthetase long-chain family member 3b 66.76(n)
    74.61(a)    		   559656  XM_683018.3  XP_688110.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Acsl1 Acyl-CoA synthetase long-chain 52.63(n)
    50.52(a)    		   46068  NM_170615.1  NP_724695.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea acs-176
    acs-46
    		 fatty Acid CoA Synthetase family member (acs-16)
    		 44(a)
    42(a)
    		 many ↔ many
    many ↔ many
    		 X(5937530-5942160)
    III(7167776-7170930)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes FAA3(YIL009W)4
    FAA11    		 Long chain fatty acyl-CoA synthetase, activates imported more4
    Faa1p1    		 46.41(n)1
    35.01(a)1    		   9(339344-341428)4
    8544951  NP_014962.31  8548084 
     NP_012257.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons LACS81 putative AMP-binding protein 54.06(n)
    48.35(a)    		   814974  NM_126468.3  NP_178516.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.73102 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.88(n)    AK100521.1 


    ENSEMBL Gene Tree for ACSL3 (if available)
    TreeFam Gene Tree for ACSL3 (if available) 

    Paralogs
    for ACSL3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACSL3 gene
    ACSBG12  ACSL62  ACSBG22  ACSL42  ACSL12  ACSL52  
    6 SIMAP similar genes for ACSL3 using alignment to 7 protein entries:     ACSL3_HUMAN (see all proteins):
    FACL4    ACSL4    ACSL1    ACSL6    ACSL5    FACL5

    ACSL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACSL3
    PGOHUM00000238200


    Genomic Variants
    for ACSL3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1555 NCBI SNPs in ACSL3 are shown (see all 1555)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs757741161,2
    		C,--223723732(+) CAGCAT/-TTTTT 2 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs603570621,2
    		C--223723733(+) TTTTTT/-GCAAT 2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1928451321,2
    		--223723772(+) ATGTAC/TATTGT 2 -- us2k10--------
    rs1430749831,2
    		--223723829(+) TTTTTC/TTTTTT 2 -- us2k10--------
    rs1853455601,2
    		--223723906(+) ACCTTC/TGCCTC 2 -- us2k10--------
    rs1901226041,2
    		--223723976(+) CACCAA/CGCCTG 2 -- us2k10--------
    rs1822863721,2
    		--223724005(+) AGTAGA/CGACAG 2 -- us2k10--------
    rs356444611,2
    		C,F,--223724047(+) ACTCCC/TGACCT 2 -- us2k13Minor allele frequency- T:0.40NA WA CSA 5
    rs1873955501,2
    		--223724062(+) TGATCC/TGCCTG 2 -- us2k10--------
    rs1416413601,2
    		--223724233(+) AAGTAA/TCTCTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACSL3 (223725652 - 223809357 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for ACSL3
         9 CNVs: 23604 44015 43472 22617 22993 98146 61888 98147 39280
         5 Indels: 26573 40424 12126 58969 42130

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ACSL3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ACSL3 for disorders           About GeneDecksing

    OMIM gene information: 602371    OMIM disorders: --

    8 diseases for ACSL3:    About MalaCards
    saethre-chotzen syndrome    craniosynostosis    hypertriglyceridemia    prostate cancer
    asthma    prostatitis    hepatitis    malaria


    Export disorders for ACSL3 gene to outside databases

    Publications
    for ACSL3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACSL3 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with ACSL3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PubMed id 18003621)1, 2 Yao H. and Ye J. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PubMed id 11707336)1, 2 Minekura H....Yamamoto T.T. (2001)
    4. Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. (PubMed id 9177793)1, 2 Minekura H.... Yamamoto T.T. (1997)
    5. Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PubMed id 15556626)1, 9 Qiao S. and Tuohimaa P. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    10. The N-terminal region of acyl-CoA synthetase 3 is esse ntial for both the localization on lipid droplets and the function in fatty acid uptake. (PubMed id 22357706)1 Poppelreuther M....Fullekrug J. (2012)

    External Searches for ACSL3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ACSL3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2181 HGNC: 3570 AceView: ACSL3 Ensembl:ENSG00000123983 euGenes: HUgn2181
    ECgene: ACSL3 Kegg: 2181 H-InvDB: ACSL3

    Other Databases showing ACSL3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ACSL3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACSL3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ACSL3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ACSL3 gene:
    Search GeneIP for patents involving ACSL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ACSL3 gene

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    About This Section

     
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