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Aliases for ACSL3 Gene

Aliases for ACSL3 Gene

  • Acyl-CoA Synthetase Long-Chain Family Member 3 2 3 5
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 3 2 3
  • Long-Chain Acyl-CoA Synthetase 3 3 4
  • EC 6.2.1.3 4 63
  • LACS 3 3 4
  • FACL3 3 4
  • ACS3 3 4
  • Lignoceroyl-CoA Synthase 3
  • PRO2194 3
  • LACS3 4

External Ids for ACSL3 Gene

Previous HGNC Symbols for ACSL3 Gene

  • FACL3

Previous GeneCards Identifiers for ACSL3 Gene

  • GC02P223968
  • GC02P223551
  • GC02P223433
  • GC02P223725
  • GC02P215580

Summaries for ACSL3 Gene

Entrez Gene Summary for ACSL3 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACSL3 Gene

ACSL3 (Acyl-CoA Synthetase Long-Chain Family Member 3) is a Protein Coding gene. Diseases associated with ACSL3 include saethre-chotzen syndrome. Among its related pathways are Adipocytokine signaling pathway and Fatty acid biosynthesis (KEGG). GO annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.

UniProtKB/Swiss-Prot for ACSL3 Gene

  • Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).

Gene Wiki entry for ACSL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL3 Gene

Genomics for ACSL3 Gene

Regulatory Elements for ACSL3 Gene

Enhancers for ACSL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACSL3 on UCSC Golden Path with GeneCards custom track

Promoters for ACSL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACSL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACSL3 Gene

Chromosome:
2
Start:
222,860,934 bp from pter
End:
222,944,639 bp from pter
Size:
83,706 bases
Orientation:
Plus strand

Genomic View for ACSL3 Gene

Genes around ACSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL3 Gene

Proteins for ACSL3 Gene

  • Protein details for ACSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95573-ACSL3_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 3
    Protein Accession:
    O95573
    Secondary Accessions:
    • Q60I92
    • Q8IUM9

    Protein attributes for ACSL3 Gene

    Size:
    720 amino acids
    Molecular mass:
    80420 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for ACSL3 Gene

Proteomics data for ACSL3 Gene at MOPED

Post-translational modifications for ACSL3 Gene

  • Ubiquitination at Lys 679
  • Modification sites at PhosphoSitePlus

Other Protein References for ACSL3 Gene

Domains & Families for ACSL3 Gene

Gene Families for ACSL3 Gene

Protein Domains for ACSL3 Gene

Suggested Antigen Peptide Sequences for ACSL3 Gene

Graphical View of Domain Structure for InterPro Entry

O95573

UniProtKB/Swiss-Prot:

ACSL3_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSL3: view

Function for ACSL3 Gene

Molecular function for ACSL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
UniProtKB/Swiss-Prot Function:
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).

Enzyme Numbers (IUBMB) for ACSL3 Gene

genes like me logo Genes that share phenotypes with ACSL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACSL3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSL3 Gene

Localization for ACSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL3 Gene

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSL3 Gene COMPARTMENTS Subcellular localization image for ACSL3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
peroxisome 5
mitochondrion 4
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACSL3: view

Pathways & Interactions for ACSL3 Gene

genes like me logo Genes that share pathways with ACSL3: view

Gene Ontology (GO) - Biological Process for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0007420 brain development IEA --
GO:0007584 response to nutrient IEA --
GO:0034379 very-low-density lipoprotein particle assembly IMP 18003621
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with ACSL3: view

No data available for SIGNOR curated interactions for ACSL3 Gene

Drugs & Compounds for ACSL3 Gene

(8) Drugs for ACSL3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icosapent Approved Nutra Target, inducer 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(33) Additional Compounds for ACSL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSL3: view

Transcripts for ACSL3 Gene

Unigene Clusters for ACSL3 Gene

Acyl-CoA synthetase long-chain family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: -
SP7:
SP8: -
SP9: -
SP10: -
SP11: - - - - - -
SP12:

ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ACSL3 Gene

GeneLoc Exon Structure for
ACSL3
ECgene alternative splicing isoforms for
ACSL3

Expression for ACSL3 Gene

mRNA expression in normal human tissues for ACSL3 Gene

Protein differential expression in normal tissues from HIPED for ACSL3 Gene

This gene is overexpressed in Nasal epithelium (7.9) and Retina (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL3 Gene



SOURCE GeneReport for Unigene cluster for ACSL3 Gene Hs.655772

genes like me logo Genes that share expression patterns with ACSL3: view

Protein tissue co-expression partners for ACSL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACSL3 Gene

Orthologs for ACSL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACSL3 35
  • 92.22 (n)
  • 95.28 (a)
ACSL3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSL3 35
  • 90.83 (n)
  • 93.89 (a)
ACSL3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsl3 35
  • 88.89 (n)
  • 92.92 (a)
Acsl3 16
Acsl3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACSL3 35
  • 99.77 (n)
  • 100 (a)
ACSL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsl3 35
  • 88.06 (n)
  • 92.36 (a)
oppossum
(Monodelphis domestica)
Mammalia ACSL3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL3 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACSL3 35
  • 79.02 (n)
  • 83.57 (a)
ACSL3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSL3 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl4 35
  • 68.55 (n)
  • 75.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33876 35
zebrafish
(Danio rerio)
Actinopterygii acsl3b 35
  • 66.76 (n)
  • 74.61 (a)
acsl3a 36
  • 69 (a)
OneToMany
acsl3b 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003623 35
  • 51.7 (n)
  • 47.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acsl 35
  • 52.6 (n)
  • 50.44 (a)
Acsl 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acs-17 36
  • 44 (a)
ManyToMany
acs-4 36
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA1 36
  • 30 (a)
ManyToMany
FAA3 36
  • 30 (a)
ManyToMany
FAA4 36
  • 30 (a)
ManyToMany
FAA3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons LACS8 35
  • 54.37 (n)
  • 48.51 (a)
rice
(Oryza sativa)
Liliopsida Os.7310 35
Os05g0317200 35
  • 54.45 (n)
  • 48.53 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7413 35
corn
(Zea mays)
Liliopsida Zm.8032 35
Species with no ortholog for ACSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACSL3 Gene

ENSEMBL:
Gene Tree for ACSL3 (if available)
TreeFam:
Gene Tree for ACSL3 (if available)

Paralogs for ACSL3 Gene

Paralogs for ACSL3 Gene

(6) SIMAP similar genes for ACSL3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ACSL3 Gene

genes like me logo Genes that share paralogs with ACSL3: view

Variants for ACSL3 Gene

Sequence variations from dbSNP and Humsavar for ACSL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1046032 - 222,930,732(+) TTTCT(C/T)TGAAG nc-transcript-variant, reference, missense
rs705727 -- 222,884,844(-) AGGCA(A/G)TAATA intron-variant
rs1550419 -- 222,928,753(+) AATAG(C/T)TGGGG intron-variant
rs1550420 -- 222,928,762(+) GGATA(C/T)CTCAG intron-variant
rs1550426 -- 222,941,476(+) CTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSL3 Gene

Variant ID Type Subtype PubMed ID
nsv3181 CNV Loss 18451855
esv2621841 CNV Deletion 19546169
nsv436299 CNV Deletion 17901297
nsv435722 CNV Deletion 17901297
nsv511839 CNV Loss 21212237
esv2151193 CNV Deletion 18987734
esv997784 CNV Deletion 20482838
esv4072 CNV Deletion 18987735
esv2721520 CNV Deletion 23290073
esv9602 CNV Loss 19470904
esv1240242 CNV Deletion 17803354
esv2652841 CNV Deletion 19546169
esv2721521 CNV Deletion 23290073
esv3725 CNV Deletion 18987735
esv1617678 CNV Deletion 17803354
nsv215259 CNV Loss 16902084
nsv819092 CNV Loss 19587683

Variation tolerance for ACSL3 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACSL3 Gene

HapMap Linkage Disequilibrium report
ACSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL3 Gene

Disorders for ACSL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACSL3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
saethre-chotzen syndrome
  • saethre-chotzen syndrome with eyelid anomalies
- elite association - COSMIC cancer census association via MalaCards
Search ACSL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACSL3

Genetic Association Database (GAD)
ACSL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACSL3
genes like me logo Genes that share disorders with ACSL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACSL3 Gene

Publications for ACSL3 Gene

  1. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PMID: 18003621) Yao H. … Ye J. (J. Biol. Chem. 2008) 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PMID: 15556626) Qiao S. … Tuohimaa P. (FEBS Lett. 2004) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for ACSL3 Gene

Sources for ACSL3 Gene

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