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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACSL3 Gene

protein-coding   GIFtS: 63
GCID: GC02P223725

Acyl-CoA Synthetase Long-Chain Family Member 3

(Previous names: fatty-acid-Coenzyme A ligase, long-chain 3)
(Previous symbol: FACL3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acyl-CoA Synthetase Long-Chain Family Member 31 2     EC 6.2.1.33 8
FACL31 2 3 5     PRO21942
ACS32 3 5     Lignoceroyl-CoA Synthase2
Fatty-Acid-Coenzyme A Ligase, Long-Chain 31 2     Long-Chain-Fatty-Acid--CoA Ligase 32
Long-Chain Acyl-CoA Synthetase 32 3     LACS33
LACS 32 3     

External Ids:    HGNC: 35701   Entrez Gene: 21812   Ensembl: ENSG000001239837   OMIM: 6023715   UniProtKB: O955733   

Export aliases for ACSL3 gene to outside databases

Previous GC identifers: GC02P223968 GC02P223551 GC02P223433 GC02P215580


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACSL3 Gene:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although
differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this
family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid
biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes
myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92%
identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACSL3 Gene: 
ACSL3 (acyl-CoA synthetase long-chain family member 3) is a protein-coding gene. Diseases associated with ACSL3 include saethre-chotzen syndrome, and craniosynostosis, and among its related super-pathways are Metabolic pathways and Fatty Acid Beta Oxidation. GO annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573
Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and
degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses
myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role
in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major
phospholipid located on the surface of VLDL (very low density lipoproteins)

Gene Wiki entry for ACSL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACSL3 gene promoter:
         Pax-2a   AP-4   CBF-C   HNF-4alpha1   CBF-A   CBF-B   CP1C   CP1A   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ACSL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACSL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34-q35   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q34-q35

ACSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSL3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223725:  view genomic region     (about GC identifiers)

Start:
223,725,652 bp from pter      End:
223,809,357 bp from pter
Size:
83,706 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573 (See protein sequence)
Recommended Name: Long-chain-fatty-acid--CoA ligase 3  
Size: 720 amino acids; 80420 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity).
Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type
III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By
similarity)
Secondary accessions: Q60I92 Q8IUM9

Explore the universe of human proteins at neXtProt for ACSL3: NX_O95573

Explore proteomics data for ACSL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95573

  • 4/9 DME Specific Peptides for ACSL3 (O95573) (see all 9)
     CGGAPLS  TGRVGAPL  LKIIDRKK  GCRIGYSSP 

    ACSL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACSL3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004448.2  NP_976251.1  

    ENSEMBL proteins: 
     ENSP00000350012   ENSP00000375918   ENSP00000438342   ENSP00000416913   ENSP00000441643  
     ENSP00000404182   ENSP00000385157  
    Reactome Protein details: O95573
    Human Recombinant Protein Products for ACSL3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for ACSL3
    OriGene Protein Over-expression Lysate for ACSL3
    OriGene MassSpec for ACSL3 
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    GenScript Custom Purified and Recombinant Proteins Services for ACSL3
    Novus Biologicals ACSL3 Proteins
    Novus Biologicals ACSL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACSL3 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005778peroxisomal membrane IEA--
    GO:0005783endoplasmic reticulum IDA14741744
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IDA--

    ACSL3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ACSL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ACS: Acyl-CoA synthetase family

    2 InterPro protein domains:
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry O95573

    ProtoNet protein and cluster: O95573

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    ACSL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACSL3_HUMAN, O95573
    Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and
    degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses
    myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role
    in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major
    phospholipid located on the surface of VLDL (very low density lipoproteins)
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA

         Enzyme Number (IUBMB): EC 6.2.1.31 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IMP--
    GO:0005524ATP binding IEA--
    GO:0019901protein kinase binding IPI--
    GO:0019904protein domain specific binding IPI--
         
    ACSL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACSL3:
     Increased cilium length after  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acsl3):
     growth/size  hematopoietic system  immune system 

    ACSL3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACSL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACSL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACSL3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACSL3 

    miRNA
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    hsa-miR-548j hsa-miR-642a hsa-miR-300 hsa-miR-188-5p hsa-miR-371-5p hsa-miR-550a* hsa-miR-548a-5p hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidACSL3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACSL3 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    2Fatty Acid Beta Oxidation
    Fatty Acid Beta Oxidation0.35
    Fatty acid degradation0.32
    Mitochondrial LC-Fatty Acid Beta-Oxidation0.35
    3fatty acid activation
    fatty acid activation0.55
    fatty acid beta-oxidation VI (peroxisome)0.46
    stearate biosynthesis I (animals)0.55
    fatty acid beta-oxidation I0.40
    4Fatty Acyl-CoA Biosynthesis
    Fatty Acyl-CoA Biosynthesis0.78
    Triglyceride Biosynthesis0.47
    Synthesis of very long-chain fatty acyl-CoAs0.78
    5eicosapentaenoate biosynthesis II (metazoa)
    gamma-linolenate biosynthesis II (animals)0.69
    eicosapentaenoate biosynthesis II (metazoa)0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/9 BioSystems Pathways for ACSL3 (see all 9)
        Fatty Acid Beta Oxidation
    stearate biosynthesis I (animals)
    gamma-linolenate biosynthesis II (animals)
    fatty acid beta-oxidation VI (peroxisome)
    fatty acid beta-oxidation I

    5/6        Reactome Pathways for ACSL3 (see all 6)
        Metabolism
    Synthesis of very long-chain fatty acyl-CoAs
    Triglyceride Biosynthesis
    Fatty Acyl-CoA Biosynthesis
    Fatty acid, triacylglycerol, and ketone body metabolism


    5         Kegg Pathways  (Kegg details for ACSL3):
        Fatty acid degradation
    Metabolic pathways
    PPAR signaling pathway
    Peroxisome
    Adipocytokine signaling pathway


    ACSL3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACSL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for ACSL3 (O955733 ENSP000003500124) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPG20Q8N0X73, ENSP000003473144I2D: score=2 STRING: ENSP00000347314
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    NDRG1Q925973, ENSP000003199774I2D: score=3 STRING: ENSP00000319977
    DDA1Q9BW613I2D: score=1 
    GBASO753233I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001676long-chain fatty acid metabolic process ----
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0007420brain development IEA--
    GO:0007584response to nutrient IEA--
    GO:0008152metabolic process ----

    ACSL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACSL3

    10/41 HMDB Compounds for ACSL3 (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----

    1 DrugBank Compound for ACSL3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IcosapentEicosapentaenoic acid (see all 4)10417-94-4targetinducer17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about ACSL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACSL3 gene (2 alternative transcripts): 
    NM_004457.3  NM_203372.1  

    Unigene Cluster for ACSL3:

    Acyl-CoA synthetase long-chain family member 3
    Hs.655772  [show with all ESTs]
    Unigene Representative Sequence: NM_004457
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357430(uc002vni.3 uc002vnj.3) ENST00000392066 ENST00000535678
    ENST00000413316 ENST00000542810 ENST00000540115 ENST00000463813 ENST00000421680
    ENST00000407441 ENST00000474422 ENST00000495541
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    Additional mRNA sequence: 

    AB061712.1 AF116690.1 AK001471.1 AK023191.1 AK314621.1 BC012066.1 BC032144.2 BC041692.1 
    D89053.1 

    20 DOTS entries:

    DT.99962976  DT.217723  DT.100813456  DT.70100809  DT.40109136  DT.91767570  DT.100813459  DT.120939750 
    DT.91767544  DT.100813468  DT.120939718  DT.405782  DT.100813460  DT.120939687  DT.120939704  DT.75196322 
    DT.91767545  DT.95316984  DT.422577  DT.95293549 

    24/379 AceView cDNA sequences (see all 379):

    BI089639 N76698 AW675700 AI340340 BX095257 AA235227 BU684792 CB149552 
    AI078690 T92314 Z41564 AA812279 AA781480 AA015802 BU734976 BC041692 
    CD677145 AW874028 AF116690 CA454816 BQ644588 NM_004457 BQ082616 AW473591 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^
    SP1:                                -     -     -     -                                                                                                         
    SP2:                                -     -     -     -           -                                               -                                             
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -         

    ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:  -     -                                 
    SP5:                                          


    ECgene alternative splicing isoforms for ACSL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACSL3 expression in normal human tissues (normalized intensities)      ACSL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGACTAGT
    ACSL3 Expression
    About this image


    ACSL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/43 selected tissues (see all 43) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Medulla Oblongata
             brain/forebrain/telencephalon   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Stem Bronchi
             lung ; pneumocytes   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Epithelium
             cervix, uterine ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See ACSL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACSL3

    SOURCE GeneReport for Unigene cluster: Hs.655772
        SABiosciences Expression via Pathway-Focused PCR Arrays including ACSL3: 
              Fatty Acid Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              PPAR Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACSL3 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acsl31 , 5 acyl-CoA synthetase long-chain family member 31, 5 88.89(n)1
    92.92(a)1
      1 (40.84 cM)5
    742051  NM_028817.31  NP_083093.21 
     786578255 
    chicken
    (Gallus gallus)
    Aves ACSL31 acyl-CoA synthetase long-chain family member 3 79.02(n)
    83.57(a)
      424810  XM_422625.3  XP_422625.3 
    lizard
    (Anolis carolinensis)
    Reptilia ACSL36
    acyl-CoA synthetase long-chain family member 3
    79(a)
    1 ↔ 1
    3(25387268-25422482)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.338762 Xenopus laevis transcribed sequence with moderate similarity more 77.48(n)    BJ624854.1 
    zebrafish
    (Danio rerio)
    Actinopterygii acsl3b1 acyl-CoA synthetase long-chain family member 3b 66.76(n)
    74.61(a)
      559656  XM_683018.3  XP_688110.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Acsl1 Acyl-CoA synthetase long-chain 52.63(n)
    50.52(a)
      46068  NM_170615.1  NP_724695.1 
    worm
    (Caenorhabditis elegans)
    Secernentea acs-176
    acs-46
    Protein ACS-4
    43(a)
    43(a)
    many ↔ many
    many ↔ many
    X(5937565-5942195)
    III(7167838-7170992)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAA3(YIL009W)4
    FAA11
    Long chain fatty acyl-CoA synthetase, activates imported more4
    Faa1p1
    46.41(n)1
    35.01(a)1
      9(339344-341428)4
    8544951  NP_014962.31  8548084 
     NP_012257.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LACS81 putative AMP-binding protein 54.06(n)
    48.35(a)
      814974  NM_126468.3  NP_178516.1 
    rice
    (Oryza sativa)
    Liliopsida Os.73102 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.88(n)    AK100521.1 


    ENSEMBL Gene Tree for ACSL3 (if available)
    TreeFam Gene Tree for ACSL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACSL3 gene
    ACSL42  
    6 SIMAP similar genes for ACSL3 using alignment to 7 protein entries:     ACSL3_HUMAN (see all proteins):
    FACL4    ACSL4    ACSL1    ACSL6    ACSL5    FACL5

    ACSL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACSL3
    PGOHUM00000238200


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1861 SNPs in ACSL3 are shown (see all 1861)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928451321,2
    --223723772(+) ATGTAC/TATTGT 2 -- us2k10--------
    rs1430749831,2
    --223723829(+) TTTTTC/TTTTTT 2 -- us2k10--------
    rs1853455601,2
    --223723906(+) ACCTTC/TGCCTC 2 -- us2k10--------
    rs1901226041,2
    --223723976(+) CACCAA/CGCCTG 2 -- us2k10--------
    rs1822863721,2
    --223724005(+) AGTAGA/CGACAG 2 -- us2k10--------
    rs356444611,2
    C,F--223724047(+) ACTCCC/TGACCT 2 -- us2k13Minor allele frequency- T:0.40NA WA CSA 5
    rs1873955501,2
    --223724062(+) TGATCC/TGCCTG 2 -- us2k10--------
    rs1416413601,2
    --223724233(+) AAGTAA/TCTCTA 2 -- us2k10--------
    rs767357321,2
    C,F--223724273(+) AACAAG/AATGAG 2 -- us2k13Minor allele frequency- A:0.07NA WA 240
    rs1461749691,2
    --223724424(+) AAGGTA/GCAATA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACSL3 (223725652 - 223809357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for ACSL3 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv3725CNV Deletion18987735
    esv1617678CNV Deletion17803354
    esv1240242CNV Deletion17803354
    nsv436299CNV Deletion17901297
    esv4072CNV Deletion18987735
    esv2721521CNV Deletion23290073
    nsv435722CNV Deletion17901297
    esv997784CNV Deletion20482838
    esv2621841CNV Deletion19546169
    esv2721520CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602371    OMIM disorders: --

    7 diseases for ACSL3:    About MalaCards
    saethre-chotzen syndrome    craniosynostosis    hypertriglyceridemia    asthma
    prostate cancer    prostatitis    hepatitis


    ACSL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACSL3

    Export disorders for ACSL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACSL3 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with ACSL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PubMed id 18003621)1, 2 Yao H. and Ye J. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PubMed id 11707336)1, 2 Minekura H....Yamamoto T.T. (2001)
    4. Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. (PubMed id 9177793)1, 2 Minekura H.... Yamamoto T.T. (1997)
    5. Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PubMed id 15556626)1, 9 Qiao S. and Tuohimaa P. (2004)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2181 HGNC: 3570 AceView: ACSL3 Ensembl:ENSG00000123983 euGenes: HUgn2181
    ECgene: ACSL3 Kegg: 2181 H-InvDB: ACSL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACSL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACSL3 gene:
    Search GeneIP for patents involving ACSL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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