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ACSL3 Gene

protein-coding GIFtS: 60

GC02P223433

acyl-CoA synthetase long-chain family member 3
(Previous names: fatty-acid-Coenzyme A ligase, long-chain 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FACL3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACS3 ^¹, ², ³, ⁵
EC 6.2.1.3 ^³
FACL3 ^², ³, ⁵
LACS3 ^³
OTTHUMP00000164212 ^²
PRO2194 ^¹, ²

Descriptions
LACS 3 ^³
Long-chain acyl-CoA synthetase 3 ^³
acyl-CoA synthetase long-chain family member 3 ^²
fatty-acid-Coenzyme A ligase, long-chain 3 ^¹, ²
lignoceroyl-CoA synthase ^²

External Ids
HGNC: 3570¹
Entrez Gene: 2181²
UniProtKB: O95573³
Ensembl: ENSG00000123983⁷

Search outside databases for aliases for ACSL3 gene

Previous GC identifers: GC02P223968 GC02P223551

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACSL3:

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase

family. Although differing in substrate specificity, subcellular localization, and tissue

distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA

esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme

is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and

eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that

of rat homolog. Two transcript variants encoding the same protein have been found for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573

Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and

degradation via beta-oxidation. Preferentially uses myristate, laurate, arachidonate and

eicosapentaenoate as substrates (By similarity)

Gene Wiki entry for ACSL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACSL3 gene

Entrez Gene cytogenetic band: 2q34-q35 Ensembl cytogenetic band: 2q36.1 HGNC cytogenetic band: 2q34-q35

ACSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P223433: (about GC identifiers)

Start:	223,433,976 bp from pter
End:	223,516,363 bp from pter
Size:	82,388 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573 (See protein sequence)

Recommended Name: Long-chain-fatty-acid--CoA ligase 3

Size: 720 amino acids; 80420 Da

Cofactor: Magnesium (By similarity)

Subcellular location: Mitochondrion outer membrane; Single-pass type III membrane protein (By

similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome

membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane;

Single-pass type III membrane protein (By similarity)

Secondary accessions: Q60I92 Q8IUM9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004448.2 NP_976251.1

ENSEMBL proteins:

ENSP00000350012 ENSP00000375918

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ACSL3)
	Human Recombinant Proteins from Abnova (ACSL3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0005777	peroxisome	IEA	--
GO:0005778	peroxisomal membrane	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--

About this table

Antibodies for ACSL3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACSL3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ACSL3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACSL3)
	Novus Biologicals Antibodies for ACSL3

Assays for ACSL3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95573

ProtoNet protein and cluster: O95573

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACSL3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACSL3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004457

Applied Biosystems Silencer® siRNAs for ACSL3

Sigma-Aldrich siRNA for ACSL3

Sigma-Aldrich shRNA for ACSL3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACSL3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004457
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004457
untagged cDNA clones in CMV expression vector (see all 2): NM_004457

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004457

UniProtKB/Swiss-Prot: ACSL3_HUMAN, O95573

Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and

degradation via beta-oxidation. Preferentially uses myristate, laurate, arachidonate and

eicosapentaenoate as substrates (By similarity)

Catalytic activity: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

Enzyme Number (IUBMB): EC 6.2.1.3

1 MGI phenotypic allele for Acsl3 (no phenotypes)

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004321	fatty-acyl-CoA synthase activity	TAS	8663269
GO:0004467	long-chain-fatty-acid-CoA ligase activity	IEA	--
GO:0005515	protein binding	IPI	17220478
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for ACSL3 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Type II Diabetes Mellitus Signaling
Pyruvate Metabolism
Glycolysis/Gluconeogenesis
Propanoate Metabolism
LPS/IL-1 Mediated Inhibition of RXR Function

GeneDecks ACSL3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ACSL3

5/29 Interacting proteins for ACSL3 (ENSP00000350012³ O95573¹) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NDRG1	Q92597¹	EBI-1190822, EBI-716486
ACOX1	ENSP00000301608³	STRING (score=.927)
ACOX3	ENSP00000348775³	STRING (score=.927)
ACADL	ENSP00000233710³	STRING (score=.899)
ACADM	ENSP00000359871³	STRING (score=.899)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006631	fatty acid metabolic process	IEA	--
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ACSL3

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACSL3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACSL3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACSL3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004457

Sigma-Aldrich siRNA for ACSL3

Sigma-Aldrich shRNA for ACSL3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004457 NM_203372

REFSEQ mRNAs for ACSL3 gene (2 alternative transcripts):

NM_004457.3 NM_203372.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004457 NM_203372

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004457
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004457
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004457

Additional cDNA sequence:

AB061712.1 AF116690.1 AK001471.1 AK023191.1 AK314621.1 BC012066.1 BC032144.2 BC041692.1

CR592887.1 CR608706.1 D89053.1

19 DOTS entries:

DT.99962976 DT.217723 DT.100813456 DT.70100809 DT.40109136 DT.91767570 DT.100813459 DT.120939750

DT.405782 DT.422577 DT.91767544 DT.100813468 DT.120939718 DT.100813460 DT.120939704 DT.75196322

DT.91767545 DT.95316984 DT.95293549

24/379 AceView cDNA sequences (see all 379 ):

AU130030 BX102306 N76698 BQ189105 BQ644588 AU139651 AL119851 CR626202

BU684792 BC032144 AW473591 BQ082616 AU121354 BG111778 AI989323 AI351449

CR604798 AA781480 BX088954 AW028979 BM705776 AA235227 CB149552 BM472141

highest scoring ESTs for ACSL3:

D89053 AA015802 AA148851 AA191465 AA352088 AA644297 AA782253 AA812279 AA854273 AA857937

Unigene Cluster for ACSL3:

Acyl-CoA synthetase long-chain family member 3

Hs.655772 [show with all ESTs]

Unigene Representative Sequence: NM_004457

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 (see all 12 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9	^	10	^
SP1:											-		-		-		-
SP2:											-		-		-		-				-																-
SP3:
SP4:											-		-		-		-		-						-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:											-		-		-		-						-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15
SP1:
SP2:
SP3:
SP4:	-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for ACSL3

2 Ensembl transcripts including schematic representations:

ENST00000357430 ENST00000392066

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACSL3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACSL3

¹ / ² / ³

5 probe-sets matching ACSL3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33880_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D89053	1.00	1.00	1.00	1
201662_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D89053	1.00	1.00	1.00	1
201661_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004457	0.60	1.00	0.82	1
201662_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201661_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACSL3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCAGACTAGT

SOURCE GeneReport for Unigene cluster: Hs.655772
Expression variation in blood from EXPOLDB for ACSL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACSL3 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACSL3¹	--	acyl-CoA synthetase long-chain family member 3	90.83(n) 93.89(a)	478927 XM_846524.1 XP_851617.1
chimpanzee (Pan troglodytes)	ACSL3¹	--	acyl-CoA synthetase long-chain family member 3	99.77(n) 100(a)	459974 XM_001166350.1 XP_001166350.1
rat (Rattus norvegicus)	Acsl3¹	--	acyl-CoA synthetase long-chain family member 3	88.06(n) 92.36(a)	114024 NM_057107.1 NP_476448.1
mouse (Mus musculus)	Acsl3^{1, 5}	1 (24.10 cM)⁵	acyl-CoA synthetase long-chain family member 3^{1, 5}	88.84(n)¹ 92.78(a)¹	74205¹ NM_001033606.1¹ NP_001028778.1¹ AK012088⁵ AK046000⁵ (see all 18)
chicken (Gallus gallus)	ACSL3¹	--	acyl-CoA synthetase long-chain family member 3	79.02(n) 83.59(a)	424810 XM_422625.2 XP_422625.2

About this table Species with no ortholog for ACSL3

ENSEMBL Gene Tree for ACSL3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACSL3 gene

ACSL4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/478 NCBI SNPs in ACSL3 are shown (see all 478 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 138)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2119160^1,2	A,C,F,H	223473735(+)	`TTGATC/TGAGGA`	2	--	int¹ ut5¹		7		NA EU EA WA	550
	rs1046108^1,2	A,C,F,H	223515501(+)	`ATTTCG/ATTGAC`	2	--	ut3¹		8		EU EA WA NA MN	742
	rs10755042^1,2	C,F,H	223516645(+)	`TAGAAC/AGTGAA`	2	--	ng3¹		7		EU EA WA NA	560
	rs4674730^1,2	C,F,H	223515624(+)	`TTTTCA/CTAGTT`	2	--	ut3¹ ese³		7		EU EA WA NA	562
	rs4674729^1,2	C,F,H	223515567(+)	`CTATCC/TCAAAG`	2	--	ut3¹		1		WA	120
--	rs16864237^1,2	F,H	223515500(+)	`TATTTC/TGTTGA`	2	--	ut3¹		6		NA EU EA	406
	rs7606898^1,2	A,C	223432934(+)	`GCCCTG/TGGCCC`	2	--	ng5¹ tfbs³		0	--	--	--	--
--	rs10755043^1,2	C,F	223516681(+)	`AATTTC/GTCTGT`	2	--	ng3¹		3		NA	142
--	rs1046109^1,2	F	223515566(+)	`TCTATT/CCCAAA`	2	--	ut3¹		3		MN NA	366
--	rs17838618^1,2	F	223516061(+)	`AAAAAC/AAAAAA`	2	--	ut3¹		1		MN	184

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HapMap Linkage Disequilibrium images for ACSL3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602371

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/22 PubMed articles for ACSL3 gene (see all 22 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PubMed id 11707336)^{3, 4} Minekura H....Yamamoto T.T. (2001)
Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. (PubMed id 9177793)^{3, 4} Minekura H.... Yamamoto T.T. (1997)
Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PubMed id 15556626)^{1, 3} Qiao S. and Tuohimaa P. (2004)
Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. (PubMed id 19221603)³ Perera F....Ho S.M. (2009)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PubMed id 18003621)³ Yao H. and Ye J. (2008)
Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation. (PubMed id 17761945)³ Zhou Y....Liu J. (2007)
The fatty acid transport protein (FATP) family: very long chain acyl-CoA synthetases or solute carriers? (PubMed id 17901542)³ Jia Z....Watkins P.A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2181	HGNC: 3570	AceView: ACSL3	Ensembl:ENSG00000123983	euGenes: HUgn2181
ECgene: ACSL3	H-InvDB: ACSL3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ACSL3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACSL3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACSL3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACSL3		Antibodies for ACSL3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACSL3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Drugs for ACSL3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACSL3

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ACSL3 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ACSL3

Summaries
for ACSL3

Genomic Location
for ACSL3

Proteins
for ACSL3

Protein Domains/
Families
for ACSL3

Gene Function
for ACSL3

Pathways & Interactions
for ACSL3

Drugs & Compounds
for ACSL3

Transcripts
for ACSL3

Expression
for ACSL3

Orthologs
for ACSL3

Paralogs
for ACSL3

SNPs/Variants
for ACSL3

Disorders & Mutations
for ACSL3

Medical News
for ACSL3

Publications
for ACSL3

Search for ACSL3

Genome Databases showing ACSL3

Other Databases showing ACSL3

Specialized Databases showing ACSL3

Licensable Technologies
for ACSL3

Services
for ACSL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACSL3 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ACSL3

Summariesfor ACSL3

Genomic Locationfor ACSL3

Proteinsfor ACSL3

Protein Domains/Familiesfor ACSL3

Gene Functionfor ACSL3

Pathways & Interactionsfor ACSL3

Drugs & Compoundsfor ACSL3

Transcriptsfor ACSL3

Expression for ACSL3

Orthologsfor ACSL3

Paralogsfor ACSL3

SNPs/Variantsfor ACSL3

Disorders & Mutationsfor ACSL3

Medical Newsfor ACSL3

Publicationsfor ACSL3

Search for ACSL3

Genome Databases showing ACSL3

Other Databases showing ACSL3

Specialized Databases showing ACSL3

Licensable Technologiesfor ACSL3

Servicesfor ACSL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACSL3

Summaries
for ACSL3

Genomic Location
for ACSL3

Proteins
for ACSL3

Protein Domains/
Families
for ACSL3

Gene Function
for ACSL3

Pathways & Interactions
for ACSL3

Drugs & Compounds
for ACSL3

Transcripts
for ACSL3

Expression
for ACSL3

Orthologs
for ACSL3

Paralogs
for ACSL3

SNPs/Variants
for ACSL3

Disorders & Mutations
for ACSL3

Medical News
for ACSL3

Publications
for ACSL3

Licensable Technologies
for ACSL3

Services
for ACSL3