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Aliases for ACSL1 Gene

Aliases for ACSL1 Gene

  • Acyl-CoA Synthetase Long-Chain Family Member 1 2 3
  • FACL2 3 4 6
  • FACL1 3 4 6
  • ACS1 3 4 6
  • LACS 3 4 6
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 2 2 3
  • Long-Chain Fatty-Acid-Coenzyme A Ligase 1 2 3
  • Long-Chain Fatty Acid-CoA Ligase 2 3 4
  • Long-Chain Acyl-CoA Synthetase 1 3 4
  • Long-Chain Acyl-CoA Synthetase 2 3 4
  • Lignoceroyl-CoA Synthase 2 3
  • Palmitoyl-CoA Ligase 1 3 4
  • Palmitoyl-CoA Ligase 2 3 4
  • Acyl-CoA Synthetase 1 3 4
  • EC 6.2.1.3 4 64
  • LACS 1 3 4
  • LACS 2 3 4
  • LACS2 3 4
  • LACS1 3 4
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 1 3
  • Long-Chain-Fatty-Acid--CoA Ligase 1 3
  • Paltimoyl-CoA Ligase 1 3
  • EC 6.2.1 64

External Ids for ACSL1 Gene

Previous Symbols for ACSL1 Gene

  • FACL2

Summaries for ACSL1 Gene

Entrez Gene Summary for ACSL1 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ACSL1 Gene

ACSL1 (Acyl-CoA Synthetase Long-Chain Family Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSBG2.

UniProtKB/Swiss-Prot for ACSL1 Gene

  • Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate

Gene Wiki entry for ACSL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL1 Gene

Genomics for ACSL1 Gene

Genomic Location for ACSL1 Gene

Start:
184,755,595 bp from pter
End:
184,826,818 bp from pter
Size:
71,224 bases
Orientation:
Minus strand

Genomic View for ACSL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL1 Gene

Proteins for ACSL1 Gene

  • Protein details for ACSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33121-ACSL1_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 1
    Protein Accession:
    P33121
    Secondary Accessions:
    • B7Z452
    • D3DP57
    • P41215
    • Q8N8V7
    • Q8TA99

    Protein attributes for ACSL1 Gene

    Size:
    698 amino acids
    Molecular mass:
    77943 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04704.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSL1 Gene

Proteomics data for ACSL1 Gene at MOPED

Post-translational modifications for ACSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys216, Lys395, Lys419, and Lys532

Domains for ACSL1 Gene

Gene Families for ACSL1 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSL1 Gene

UniProtKB/Swiss-Prot:

ACSL1_HUMAN
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.:
    • P33121
genes like me logo Genes that share domains with ACSL1: view

Function for ACSL1 Gene

Molecular function for ACSL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
UniProtKB/Swiss-Prot Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate

Enzyme Numbers (IUBMB) for ACSL1 Gene

Gene Ontology (GO) - Molecular Function for ACSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity TAS --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACSL1: view
genes like me logo Genes that share phenotypes with ACSL1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACSL1 Gene

Localization for ACSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL1 Gene

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSL1 Gene COMPARTMENTS Subcellular localization image for ACSL1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
peroxisome 5
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ACSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 22022213
GO:0005741 mitochondrial outer membrane TAS --
GO:0005778 peroxisomal membrane IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with ACSL1: view

Pathways for ACSL1 Gene

genes like me logo Genes that share pathways with ACSL1: view

Gene Ontology (GO) - Biological Process for ACSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IDA 22022213
GO:0006631 fatty acid metabolic process --
GO:0006641 triglyceride metabolic process --
GO:0007584 response to nutrient IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ACSL1: view

Compounds for ACSL1 Gene

(47) HMDB Compounds for ACSL1 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(2) Drugbank Compounds for ACSL1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8 target product of
Adenosine triphosphate
  • 5'-ATP
56-65-5 target

(6) Novoseek inferred chemical compound relationships for ACSL1 Gene

Compound -log(P) Hits PubMed IDs
acyl-coa 80.4 10
fatty acid 56.7 8
oleic acid 41 2
lactose 39 2
galactose 36 1
genes like me logo Genes that share compounds with ACSL1: view

Transcripts for ACSL1 Gene

Unigene Clusters for ACSL1 Gene

Acyl-CoA synthetase long-chain family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - - -
SP2:
SP3: - - - - - - - - - - -
SP4:
SP5: - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - -
SP15:
SP16: - - - -
SP17: - - - - - - - - -
SP18:
SP19:
SP20:
SP21:

ExUns: 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29 ^
SP1: - - - - - -
SP2: - -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - -
SP20:
SP21: -

ExUns: 30 ^ 31a · 31b · 31c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ACSL1 Gene

GeneLoc Exon Structure for
ACSL1
ECgene alternative splicing isoforms for
ACSL1

Expression for ACSL1 Gene

mRNA expression in normal human tissues for ACSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACSL1 Gene

This gene is overexpressed in Whole Blood (14.4), Liver (6.1), and Muscle - Skeletal (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL1 Gene

SOURCE GeneReport for Unigene cluster for ACSL1 Gene Hs.406678

mRNA Expression by UniProt/SwissProt for ACSL1 Gene

P33121-ACSL1_HUMAN
Tissue specificity: Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.
genes like me logo Genes that share expressions with ACSL1: view

Orthologs for ACSL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSL1 36
  • 99.43 (n)
  • 99.14 (a)
ACSL1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSL1 36
  • 85.63 (n)
  • 88.54 (a)
ACSL1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSL1 36
  • 86.91 (n)
  • 90.26 (a)
ACSL1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsl1 36
  • 84 (n)
  • 83.95 (a)
Acsl1 16
Acsl1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSL1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL1 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsl1 36
  • 83.67 (n)
  • 84.81 (a)
chicken
(Gallus gallus)
Aves ACSL1 36
  • 73.78 (n)
  • 76.79 (a)
ACSL1 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSL1 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl1 36
  • 71.35 (n)
  • 75.36 (a)
Str.1693 36
zebrafish
(Danio rerio)
Actinopterygii acsl1a 37
  • 70 (a)
OneToMany
acsl1b 37
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3961 37
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acs-13 37
  • 47 (a)
ManyToMany
acs-5 37
  • 44 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA2 37
  • 30 (a)
OneToMany
FAA2 39
soybean
(Glycine max)
eudicotyledons Gma.7613 36
thale cress
(Arabidopsis thaliana)
eudicotyledons LACS7 36
  • 51.53 (n)
  • 43.93 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9051 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
ManyToMany
CSA.10659 37
  • 49 (a)
ManyToMany
Species with no ortholog for ACSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACSL1 Gene

ENSEMBL:
Gene Tree for ACSL1 (if available)
TreeFam:
Gene Tree for ACSL1 (if available)

Paralogs for ACSL1 Gene

Paralogs for ACSL1 Gene

genes like me logo Genes that share paralogs with ACSL1: view

Variants for ACSL1 Gene

Sequence variations from dbSNP and Humsavar for ACSL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs8086 -- 184,756,267(-) GTGAC(A/G)CCTGA utr-variant-3-prime
rs735948 -- 184,795,335(+) ATTTC(C/T)GTCCT intron-variant
rs735949 -- 184,795,078(+) ACAAA(C/T)ACACA intron-variant
rs745805 -- 184,796,978(-) GAAGG(A/T)CTGTC intron-variant
rs879779 -- 184,783,045(-) CCGTC(C/T)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSL1 Gene

Variant ID Type Subtype PubMed ID
nsv830168 CNV Loss 17160897
esv2662137 CNV Deletion 23128226
nsv822880 CNV Gain 20364138
esv28765 CNV Loss 19812545

Relevant External Links for ACSL1 Gene

HapMap Linkage Disequilibrium report
ACSL1
Human Gene Mutation Database (HGMD)
ACSL1

Disorders for ACSL1 Gene

(2) Novoseek inferred disease relationships for ACSL1 Gene

Disease -log(P) Hits PubMed IDs
obesity 26.9 2
insulin resistance 18 2

Relevant External Links for ACSL1

Genetic Association Database (GAD)
ACSL1
Human Genome Epidemiology (HuGE) Navigator
ACSL1
genes like me logo Genes that share disorders with ACSL1: view

No data available for UniProtKB/Swiss-Prot for ACSL1 Gene

Publications for ACSL1 Gene

  1. Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1). (PMID: 1531127) Stanczak H. … Singh I. (Cytogenet. Cell Genet. 1992) 2 3
  2. Human long-chain acyl-CoA synthetase: structure and chromosomal location. (PMID: 1607358) Abe T. … Yamamoto T. (J. Biochem. 1992) 3 4
  3. Structure and regulation of rat long-chain acyl-CoA synthetase. (PMID: 2341402) Suzuki H. … Yamamoto T. (J. Biol. Chem. 1990) 2 3
  4. Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression. (PMID: 8584017) Ghosh B. … Singh I. (Mol. Cell. Biochem. 1995) 3 4
  5. Identification and molecular characterization of acyl-CoA synthetase in human red cells and erythroid precursor. (PMID: 10548543) Malhotra K.T. … Kuypers F.A. (Biochem. J. 1999) 3 4

Products for ACSL1 Gene

Sources for ACSL1 Gene

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