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Aliases for ACSL1 Gene

Aliases for ACSL1 Gene

  • Acyl-CoA Synthetase Long-Chain Family Member 1 2 3 5
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 2 2 3
  • Long-Chain Fatty-Acid-Coenzyme A Ligase 1 2 3
  • Long-Chain Fatty Acid-CoA Ligase 2 3 4
  • Long-Chain Acyl-CoA Synthetase 1 3 4
  • Long-Chain Acyl-CoA Synthetase 2 3 4
  • Lignoceroyl-CoA Synthase 2 3
  • Palmitoyl-CoA Ligase 1 3 4
  • Palmitoyl-CoA Ligase 2 3 4
  • Acyl-CoA Synthetase 1 3 4
  • EC 6.2.1.3 4 63
  • LACS 1 3 4
  • LACS 2 3 4
  • FACL2 3 4
  • FACL1 3 4
  • LACS1 3 4
  • LACS2 3 4
  • ACS1 3 4
  • LACS 3 4
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 1 3
  • Paltimoyl-CoA Ligase 1 3
  • EC 6.2.1 63

External Ids for ACSL1 Gene

Previous HGNC Symbols for ACSL1 Gene

  • FACL2

Previous GeneCards Identifiers for ACSL1 Gene

  • GC04M186373
  • GC04M186051
  • GC04M185914
  • GC04M185676
  • GC04M181430

Summaries for ACSL1 Gene

Entrez Gene Summary for ACSL1 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ACSL1 Gene

ACSL1 (Acyl-CoA Synthetase Long-Chain Family Member 1) is a Protein Coding gene. Diseases associated with ACSL1 include very long-chain acyl-coenzyme a dehydrogenase deficiency and hodgkin's lymphoma, mixed cellularity. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSBG2.

UniProtKB/Swiss-Prot for ACSL1 Gene

  • Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

Gene Wiki entry for ACSL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL1 Gene

Genomics for ACSL1 Gene

Regulatory Elements for ACSL1 Gene

Promoters for ACSL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACSL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACSL1 Gene

Chromosome:
4
Start:
184,755,595 bp from pter
End:
184,826,818 bp from pter
Size:
71,224 bases
Orientation:
Minus strand

Genomic View for ACSL1 Gene

Genes around ACSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL1 Gene

Proteins for ACSL1 Gene

  • Protein details for ACSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33121-ACSL1_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 1
    Protein Accession:
    P33121
    Secondary Accessions:
    • B7Z452
    • D3DP57
    • P41215
    • Q8N8V7
    • Q8TA99

    Protein attributes for ACSL1 Gene

    Size:
    698 amino acids
    Molecular mass:
    77943 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04704.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSL1 Gene

Proteomics data for ACSL1 Gene at MOPED

Post-translational modifications for ACSL1 Gene

  • Ubiquitination at Lys 216, Lys 395, Lys 419, and Lys 532
  • Glycosylation at Ser 135
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ACSL1 (ACSL1)

Domains & Families for ACSL1 Gene

Gene Families for ACSL1 Gene

Protein Domains for ACSL1 Gene

Graphical View of Domain Structure for InterPro Entry

P33121

UniProtKB/Swiss-Prot:

ACSL1_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSL1: view

Function for ACSL1 Gene

Molecular function for ACSL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
UniProtKB/Swiss-Prot Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

Enzyme Numbers (IUBMB) for ACSL1 Gene

genes like me logo Genes that share phenotypes with ACSL1: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSL1 Gene

Localization for ACSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL1 Gene

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSL1 Gene COMPARTMENTS Subcellular localization image for ACSL1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
peroxisome 5
cytosol 3
nucleus 3
plasma membrane 3
chloroplast 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ACSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 22022213
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACSL1: view

Pathways & Interactions for ACSL1 Gene

genes like me logo Genes that share pathways with ACSL1: view

Gene Ontology (GO) - Biological Process for ACSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process IEA --
GO:0007584 response to nutrient IEA --
GO:0010033 response to organic substance IEA --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0033211 adiponectin-activated signaling pathway IEA --
genes like me logo Genes that share ontologies with ACSL1: view

No data available for SIGNOR curated interactions for ACSL1 Gene

Drugs & Compounds for ACSL1 Gene

(10) Drugs for ACSL1 Gene - From: HMDB, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra Target, product of 0
Adenosine triphosphate Approved Nutra Target 0
Diphosphate Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Propionyl-CoA Experimental Pharma 0

(42) Additional Compounds for ACSL1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSL1: view

Transcripts for ACSL1 Gene

Unigene Clusters for ACSL1 Gene

Acyl-CoA synthetase long-chain family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - - -
SP2:
SP3: - - - - - - - - - - -
SP4:
SP5: - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - -
SP15:
SP16: - - - -
SP17: - - - - - - - - -
SP18:
SP19:
SP20:
SP21:

ExUns: 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29 ^
SP1: - - - - - -
SP2: - -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - -
SP20:
SP21: -

ExUns: 30 ^ 31a · 31b · 31c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ACSL1 Gene

GeneLoc Exon Structure for
ACSL1
ECgene alternative splicing isoforms for
ACSL1

Expression for ACSL1 Gene

mRNA expression in normal human tissues for ACSL1 Gene

mRNA differential expression in normal tissues according to GTEx for ACSL1 Gene

This gene is overexpressed in Whole Blood (x14.4), Liver (x6.1), and Muscle - Skeletal (x5.8).

Protein differential expression in normal tissues from HIPED for ACSL1 Gene

This gene is overexpressed in Liver (24.5), Nasopharynx (14.4), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL1 Gene



SOURCE GeneReport for Unigene cluster for ACSL1 Gene Hs.406678

mRNA Expression by UniProt/SwissProt for ACSL1 Gene

P33121-ACSL1_HUMAN
Tissue specificity: Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.
genes like me logo Genes that share expression patterns with ACSL1: view

Protein tissue co-expression partners for ACSL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ACSL1 Gene

Orthologs for ACSL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSL1 35
  • 99.43 (n)
  • 99.14 (a)
ACSL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSL1 36
  • 90 (a)
OneToOne
ACSL1 35
  • 85.63 (n)
  • 88.54 (a)
dog
(Canis familiaris)
Mammalia ACSL1 35
  • 86.91 (n)
  • 90.26 (a)
ACSL1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsl1 16
Acsl1 35
  • 84 (n)
  • 83.95 (a)
Acsl1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSL1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsl1 35
  • 83.67 (n)
  • 84.81 (a)
chicken
(Gallus gallus)
Aves ACSL1 36
  • 78 (a)
OneToOne
ACSL1 35
  • 73.78 (n)
  • 76.79 (a)
lizard
(Anolis carolinensis)
Reptilia ACSL1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl1 35
  • 71.35 (n)
  • 75.36 (a)
Str.1693 35
zebrafish
(Danio rerio)
Actinopterygii acsl1a 36
  • 70 (a)
OneToMany
acsl1b 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3961 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acs-13 36
  • 47 (a)
ManyToMany
acs-5 36
  • 44 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA2 36
  • 30 (a)
OneToMany
FAA2 38
soybean
(Glycine max)
eudicotyledons Gma.7613 35
thale cress
(Arabidopsis thaliana)
eudicotyledons LACS7 35
  • 51.53 (n)
  • 43.93 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9051 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
ManyToMany
CSA.10659 36
  • 49 (a)
ManyToMany
Species with no ortholog for ACSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACSL1 Gene

ENSEMBL:
Gene Tree for ACSL1 (if available)
TreeFam:
Gene Tree for ACSL1 (if available)

Paralogs for ACSL1 Gene

Paralogs for ACSL1 Gene

genes like me logo Genes that share paralogs with ACSL1: view

Variants for ACSL1 Gene

Sequence variations from dbSNP and Humsavar for ACSL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs879779 -- 184,783,045(-) CCGTC(C/T)CTGGC intron-variant
rs902177 -- 184,807,685(+) AAACT(C/T)TGGAT intron-variant, upstream-variant-2KB
rs1803898 -- 184,780,395(-) CTGAT(A/C)CAGAA intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs1803899 -- 184,755,786(-) ATTGT(A/C)ATTGT utr-variant-3-prime
rs1803900 -- 184,755,967(-) GGATT(A/C)ACTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACSL1 Gene

Variant ID Type Subtype PubMed ID
nsv830168 CNV Loss 17160897
esv2662137 CNV Deletion 23128226
nsv822880 CNV Gain 20364138
esv28765 CNV Loss 19812545

Variation tolerance for ACSL1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACSL1 Gene

HapMap Linkage Disequilibrium report
ACSL1
Human Gene Mutation Database (HGMD)
ACSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL1 Gene

Disorders for ACSL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ACSL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
very long-chain acyl-coenzyme a dehydrogenase deficiency
  • very long-chain acyl-coa dehydrogenase deficiency
hodgkin's lymphoma, mixed cellularity
  • hodgkin lymphoma, mixed cellularity
- elite association - COSMIC cancer census association via MalaCards
Search ACSL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACSL1

Genetic Association Database (GAD)
ACSL1
Human Genome Epidemiology (HuGE) Navigator
ACSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACSL1
genes like me logo Genes that share disorders with ACSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACSL1 Gene

Publications for ACSL1 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1). (PMID: 1531127) Stanczak H. … Singh I. (Cytogenet. Cell Genet. 1992) 2 3
  3. Structure and regulation of rat long-chain acyl-CoA synthetase. (PMID: 2341402) Suzuki H. … Yamamoto T. (J. Biol. Chem. 1990) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Protein mediated fatty acid uptake: synergy between CD36/FAT-facilitated transport and acyl-CoA synthetase-driven metabolism. (PMID: 24503477) Schneider H. … FA1llekrug J. (Arch. Biochem. Biophys. 2014) 3

Products for ACSL1 Gene

Sources for ACSL1 Gene

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