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Aliases for ACSF2 Gene

Aliases for ACSF2 Gene

  • Acyl-CoA Synthetase Family Member 2 2 3 5
  • PPARG Binding, Long Chain Fatty Acid Acyl Co-A Ligase Like 3
  • EC 6.2.1.26 63
  • EC 6.2.1.- 4
  • EC 6.2.1 63
  • AVYV493 3
  • ACSMW 3

External Ids for ACSF2 Gene

Previous GeneCards Identifiers for ACSF2 Gene

  • GC17P045859
  • GC17P048503
  • GC17P043871

Summaries for ACSF2 Gene

GeneCards Summary for ACSF2 Gene

ACSF2 (Acyl-CoA Synthetase Family Member 2) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include ligase activity. An important paralog of this gene is ACSF3.

UniProtKB/Swiss-Prot for ACSF2 Gene

  • Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSF2 Gene

Genomics for ACSF2 Gene

Regulatory Elements for ACSF2 Gene

Enhancers for ACSF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACSF2 on UCSC Golden Path with GeneCards custom track

Promoters for ACSF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACSF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACSF2 Gene

Chromosome:
17
Start:
50,426,158 bp from pter
End:
50,474,845 bp from pter
Size:
48,688 bases
Orientation:
Plus strand

Genomic View for ACSF2 Gene

Genes around ACSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSF2 Gene

Proteins for ACSF2 Gene

  • Protein details for ACSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CM8-ACSF2_HUMAN
    Recommended name:
    Acyl-CoA synthetase family member 2, mitochondrial
    Protein Accession:
    Q96CM8
    Secondary Accessions:
    • B4DFQ6
    • B4DHT5
    • B4DUF5
    • Q9H7G2

    Protein attributes for ACSF2 Gene

    Size:
    615 amino acids
    Molecular mass:
    68125 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSF2 Gene

Proteomics data for ACSF2 Gene at MOPED

Post-translational modifications for ACSF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ACSF2 Gene

Gene Families for ACSF2 Gene

Protein Domains for ACSF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CM8

UniProtKB/Swiss-Prot:

ACSF2_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSF2: view

Function for ACSF2 Gene

Molecular function for ACSF2 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
UniProtKB/Swiss-Prot Induction:
By PPARG.

Enzyme Numbers (IUBMB) for ACSF2 Gene

Gene Ontology (GO) - Molecular Function for ACSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with ACSF2: view
genes like me logo Genes that share phenotypes with ACSF2: view

Animal Models for ACSF2 Gene

MGI Knock Outs for ACSF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACSF2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACSF2 Gene

Localization for ACSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSF2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSF2 Gene COMPARTMENTS Subcellular localization image for ACSF2 gene
Compartment Confidence
mitochondrion 5
cytosol 3
cytoskeleton 2
nucleus 2
peroxisome 2
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ACSF2 Gene

Pathways & Interactions for ACSF2 Gene

genes like me logo Genes that share pathways with ACSF2: view

Gene Ontology (GO) - Biological Process for ACSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019432 triglyceride biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ACSF2: view

No data available for SIGNOR curated interactions for ACSF2 Gene

Drugs & Compounds for ACSF2 Gene

(1) Drugs for ACSF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACSF2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSF2: view

Transcripts for ACSF2 Gene

Unigene Clusters for ACSF2 Gene

Acyl-CoA synthetase family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for ACSF2 Gene

GeneLoc Exon Structure for
ACSF2
ECgene alternative splicing isoforms for
ACSF2

Expression for ACSF2 Gene

mRNA expression in normal human tissues for ACSF2 Gene

mRNA differential expression in normal tissues according to GTEx for ACSF2 Gene

This gene is overexpressed in Kidney - Cortex (x6.4) and Adrenal Gland (x4.9).

Protein differential expression in normal tissues from HIPED for ACSF2 Gene

This gene is overexpressed in Kidney (21.9) and Adrenal (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSF2 Gene



SOURCE GeneReport for Unigene cluster for ACSF2 Gene Hs.288959

genes like me logo Genes that share expression patterns with ACSF2: view

Protein tissue co-expression partners for ACSF2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ACSF2 Gene

Orthologs for ACSF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACSF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACSF2 35
  • 87.15 (n)
  • 84.88 (a)
ACSF2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSF2 35
  • 86.02 (n)
  • 81.79 (a)
ACSF2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsf2 35
  • 82.55 (n)
  • 78.86 (a)
Acsf2 16
Acsf2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACSF2 35
  • 99.43 (n)
  • 99.06 (a)
ACSF2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsf2 35
  • 82.82 (n)
  • 80 (a)
oppossum
(Monodelphis domestica)
Mammalia ACSF2 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves ACSF2 35
  • 66.43 (n)
  • 63.67 (a)
ACSF2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSF2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsf2 35
  • 62.66 (n)
  • 59.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16511 35
zebrafish
(Danio rerio)
Actinopterygii acsf2 35
  • 60.62 (n)
  • 57.17 (a)
wufi49b09 35
acsf2 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008557 35
  • 52.5 (n)
  • 42.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12512 35
  • 52.62 (n)
  • 41.05 (a)
CG12512 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea acs-1 35
  • 50.85 (n)
  • 45.64 (a)
acs-1 36
  • 41 (a)
OneToMany
acs-10 36
  • 22 (a)
OneToMany
acs-12 36
  • 18 (a)
OneToMany
acs-14 36
  • 26 (a)
OneToMany
acs-2 36
  • 38 (a)
OneToMany
acs-6 36
  • 22 (a)
OneToMany
acs-7 36
  • 25 (a)
OneToMany
acs-9 36
  • 24 (a)
OneToMany
mec-18 36
  • 18 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06063 35
  • 48.77 (n)
  • 35.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for ACSF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACSF2 Gene

ENSEMBL:
Gene Tree for ACSF2 (if available)
TreeFam:
Gene Tree for ACSF2 (if available)

Paralogs for ACSF2 Gene

Paralogs for ACSF2 Gene

genes like me logo Genes that share paralogs with ACSF2: view

Variants for ACSF2 Gene

Sequence variations from dbSNP and Humsavar for ACSF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17856448 - 50,460,772(+) TGTGG(G/T)CCAGT intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs3744523 - 50,463,452(-) TGCCA(C/T)GGAAC nc-transcript-variant, reference, missense
rs7627 -- 50,474,793(+) CCCCT(C/G)TCTGT nc-transcript-variant, utr-variant-3-prime
rs1010319 -- 50,429,346(-) AAATC(A/T)GTCAG intron-variant
rs1052585 -- 50,474,648(+) CAGTT(C/T)TGAGC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACSF2 Gene

Variant ID Type Subtype PubMed ID
nsv833476 CNV Loss 17160897
nsv2080 CNV Loss 18451855
dgv3228n71 CNV Gain 21882294
nsv908600 CNV Gain 21882294
nsv2081 CNV Loss 18451855

Variation tolerance for ACSF2 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACSF2 Gene

Disorders for ACSF2 Gene

Relevant External Links for ACSF2

Genetic Association Database (GAD)
ACSF2
Human Genome Epidemiology (HuGE) Navigator
ACSF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACSF2

No disorders were found for ACSF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSF2 Gene

Publications for ACSF2 Gene

  1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for ACSF2 Gene

Sources for ACSF2 Gene

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