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ACSF2 Gene

protein-coding   GIFtS: 50
GCID: GC17P048503

Acyl-CoA Synthetase Family Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Synthetase Family Member 21 2     EC 6.2.1.-3
ACSMW2     FLJ209205
AVYV4932     EC 6.2.18
Acyl-CoA Synthetase Family Member 2, Mitochondrial2     EC 6.2.1.268
PPARG Binding, Long Chain Fatty Acid Acyl Co-A Ligase Like2     

External Ids:    HGNC: 261011   Entrez Gene: 802212   Ensembl: ENSG000001671077   OMIM: 6104655   UniProtKB: Q96CM83   

Export aliases for ACSF2 gene to outside databases

Previous GC identifers: GC17P045859 GC17P043871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ACSF2 Gene:
ACSF2 (acyl-CoA synthetase family member 2) is a protein-coding gene. Diseases associated with ACSF2 include tuberculosis, and malaria. GO annotations related to this gene include ligase activity. An important paralog of this gene is C10orf129.

UniProtKB/Swiss-Prot: ACSF2_HUMAN, Q96CM8
Function: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with
CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACSF2 gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   HNF-4alpha1   RORalpha2   COUP-TF   FOXO4   FOXO1a   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACSF2 promoter sequence
   Search Chromatin IP Primers for ACSF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACSF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

ACSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSF2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048503:  view genomic region     (about GC identifiers)

Start:
48,503,519 bp from pter      End:
48,552,206 bp from pter
Size:
48,688 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ACSF2_HUMAN, Q96CM8 (See protein sequence)
Recommended Name: Acyl-CoA synthetase family member 2, mitochondrial precursor  
Size: 615 amino acids; 68125 Da
Secondary accessions: Q9H7G2

Explore the universe of human proteins at neXtProt for ACSF2: NX_Q96CM8

Explore proteomics data for ACSF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACSF2 (Q96CM8) (see all 13)
     IRGYCVM  ENSPVTF  GGENIYPA  PKGATLSH 


    See ACSF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001275897.1  NP_001275898.1  NP_001275899.1  NP_001275900.1  NP_001275901.1  NP_079425.3  

    ENSEMBL proteins: 
     ENSP00000425332   ENSP00000300441   ENSP00000426730   ENSP00000424842   ENSP00000425964  
     ENSP00000401831   ENSP00000421884   ENSP00000422546   ENSP00000421558   ENSP00000437987  

    ACSF2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ACSF2
    OriGene Custom MassSpec
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    Novus Biologicals ACSF2 Protein
    Novus Biologicals ACSF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACSF2

    ACSF2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for ACSF2

    ACSF2 Assay Products:

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    Cloud-Clone Corp. ELISAs for ACSF2
    Cloud-Clone Corp. CLIAs for ACSF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACS: Acyl-CoA synthetase family

    3 InterPro protein domains:
     IPR025110 AMP-bd_C
     IPR020845 AMP-binding_CS
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry Q96CM8

    ProtoNet protein and cluster: Q96CM8

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACSF2_HUMAN, Q96CM8
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    ACSF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACSF2_HUMAN, Q96CM8
    Function: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with
    CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation
    Induction: By PPARG

         Enzyme Numbers (IUBMB): EC 6.2.1.262 EC 6.2.12 EC 6.2.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005524ATP binding IEA--
    GO:0016874ligase activity IEA--
         
    ACSF2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Acsf2):
     normal 

    ACSF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Acsf2tm1(KOMP)Vlcg for ACSF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACSF2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACSF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACSF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACSF2:
    hsa-mir-26b-5p (MIRT029317), hsa-mir-335-5p (MIRT017740)

    Block miRNA regulation of human, mouse, rat ACSF2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ACSF2:
    hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidACSF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACSF2
    Predesigned siRNA for gene silencing in human, mouse, rat ACSF2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ACSF2 (NM_025149)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSF2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ACSF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACSF2_HUMAN, Q96CM8: Mitochondrion (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytoskeleton1
    cytosol1
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    ACSF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACSF2
    Interactions:

        Search GeneGlobe Interaction Network for ACSF2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for ACSF2 (Q96CM83 ENSP000003004414) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6IP1Q150413I2D: score=1 
    CMTM5Q96DZ93I2D: score=1 
    CREB3O438893I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    LSSENSP000003487624STRING: ENSP00000348762
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IEA--
    GO:0008152metabolic process ----

    ACSF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACSF2

    Selected HMDB Compounds for ACSF2 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ACSF2 gene (6 alternative transcripts): 
    NM_001288968.1  NM_001288969.1  NM_001288970.1  NM_001288971.1  NM_001288972.1  NM_025149.5  

    Unigene Cluster for ACSF2:

    Acyl-CoA synthetase family member 2
    Hs.288959  [show with all ESTs]
    Unigene Representative Sequence: NM_025149
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000510410 ENST00000300441(uc002iqu.2 uc010wml.1 uc010wmn.1 uc010wmo.1)
    ENST00000504945 ENST00000503408 ENST00000506582 ENST00000504392 ENST00000427954(uc010wmm.1)
    ENST00000502667 ENST00000570356 ENST00000506052 ENST00000513101 ENST00000508245
    ENST00000510262 ENST00000507769 ENST00000509806 ENST00000513544 ENST00000511288
    ENST00000506085(uc010dbt.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACSF2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ACSF2:
    hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidACSF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACSF2
    Predesigned siRNA for gene silencing in human, mouse, rat ACSF2
    Clone
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    OriGene clones in human, mouse for ACSF2 (see all 8)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACSF2 (NM_025149)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSF2
    Primer
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    OriGene qPCR primer pairs and template standards for ACSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for ACSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACSF2
      QuantiTect SYBR Green Assays in human, mouse, rat ACSF2
      QuantiFast Probe-based Assays in human, mouse, rat ACSF2

    Additional mRNA sequence: 

    AK024573.1 AK225044.1 AK225561.1 AK294205.1 AK295258.1 AK300145.1 AK300625.1 AK308584.1 
    AK311109.1 AY358660.1 BC012053.1 BC014123.2 

    19 DOTS entries:

    DT.315197  DT.100826821  DT.121003391  DT.121003382  DT.95109217  DT.100025467  DT.121003392  DT.121003402 
    DT.100826822  DT.100826825  DT.121003399  DT.40119952  DT.100826829  DT.102824827  DT.121003350  DT.92423855 
    DT.97845305  DT.102824828  DT.121003396 

    Selected AceView cDNA sequences (see all 194):

    BQ017436 BC012053 BI760246 CD519579 BX380127 CA413213 AA247575 BM544856 
    CB145206 D45574 BM919815 BX376654 BM672517 BM924432 BX381854 BI752270 
    CD558995 BX400785 CR617763 BX358071 AI635452 BQ574528 AL527342 AL573925 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACSF2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
    SP1:                    -           -           -                                                                                                         
    SP2:                    -           -     -     -                                                                                                         
    SP3:                                                                                            -     -                             -                     
    SP4:                                                                                                                                                      
    SP5:                    -           -                                                                                                                     


    ECgene alternative splicing isoforms for ACSF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACSF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGCTACT
    ACSF2 Expression
    About this image

    ACSF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACSF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288959
        Custom PCR Arrays for ACSF2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ACSF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ACSF2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acsf21 , 5 acyl-CoA synthetase family member 21, 5 82.55(n)1
    78.86(a)1
      11 (58.90 cM)5
    2648951  NM_153807.21  NP_722502.11 
     945571025 
    chicken
    (Gallus gallus)
    Aves ACSF21 acyl-CoA synthetase family member 2 66.43(n)
    63.67(a)
      422102  XM_420105.4  XP_420105.3 
    lizard
    (Anolis carolinensis)
    Reptilia ACSF26
    acyl-CoA synthetase family member 2
    60(a)
    1 ↔ 1
    2(116248664-116309329)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165112 Xenopus laevis transcribed sequence with weak similarity more 75.62(n)    BX850807.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi49b092 Transcribed sequence with weak similarity to protein more 74.63(n)    CK028106.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG125121 CG12512 52.62(n)
    41.05(a)
      33766  NM_135080.2  NP_608924.1 
    worm
    (Caenorhabditis elegans)
    Secernentea acs-11 acs-1 50.85(n)
    45.64(a)
      179043  NM_001028767.4  NP_001023938.1 


    ENSEMBL Gene Tree for ACSF2 (if available)
    TreeFam Gene Tree for ACSF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACSF2 gene
    C10orf1292  ACSM52  ACSM32  ACSS22  ACSM2A2  ACSM12  ACSM42  ACSM2B2  
    ACSS12  

    ACSF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACSF2 (see all 930)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99039591,2
    C,F,H--48501657(+) TGGCCG/AACTAC 1 -- us2k124Minor allele frequency- A:0.37NS EA NA WA CSA 2765
    rs781532971,2
    F--48501707(+) GCGTGA/TAGTTG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs285876671,2
    C,F--48501726(+) ATCCCC/TATTTG 1 -- us2k13Minor allele frequency- T:0.16WA 122
    rs1452903881,2
    --48501741(+) ATAACA/GAGGCT 1 -- us2k10--------
    rs80658061,2
    A--48501748(+) ggctgA/Gagagg 1 -- us2k10--------
    rs80658081,2
    A--48501758(+) gccccA/Gtgact 1 -- us2k1 tfbs30--------
    rs1479815931,2
    --48501759(+) CCCCGC/TGACTT 1 -- us2k10--------
    rs1416065601,2
    --48501782(+) AAAGAA/GACTAC 1 -- us2k10--------
    rs124511661,2
    H--48501930(+) AGAGCC/TTGGCA 1 -- us2k10--------
    rs80716081,2
    A,H--48501958(+) AACTGA/GTGGCT 1 -- us2k14Minor allele frequency- G:0.00NS EA 416

    HapMap Linkage Disequilibrium report for ACSF2 (48503519 - 48552206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ACSF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833476CNV Loss17160897
    nsv2081CNV Loss18451855
    nsv2080CNV Loss18451855
    dgv3228n71CNV Gain21882294
    nsv908600CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610465    OMIM disorders: --

    2 diseases for ACSF2:    About MalaCards
    tuberculosis    malaria


    ACSF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACSF2
    Human Genome Epidemiology (HuGE) Navigator: ACSF2 (1 document)

    Export disorders for ACSF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACSF2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ACSF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PubMed id 17762044)1, 2, 3 Watkins P.A.... Pevsner J. (J. Lipid Res. 2007)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Identification of novel PPARgamma target genes in primary human adipocytes. (PubMed id 16380219)1, 2 Perera R.J....Dean N.M. (Gene 2006)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 80221 HGNC: 26101 AceView: FLJ20920 Ensembl:ENSG00000167107 euGenes: HUgn80221
    ECgene: ACSF2 H-InvDB: ACSF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ACSF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ACSF2 gene:
    Search GeneIP for patents involving ACSF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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