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Aliases for ACSF2 Gene

Aliases for ACSF2 Gene

  • Acyl-CoA Synthetase Family Member 2 2 3
  • PPARG Binding, Long Chain Fatty Acid Acyl Co-A Ligase Like 3
  • Acyl-CoA Synthetase Family Member 2, Mitochondrial 3
  • EC 63
  • EC 6.2.1.- 4
  • FLJ20920 6
  • EC 6.2.1 63
  • AVYV493 3
  • ACSMW 3

External Ids for ACSF2 Gene

Previous GeneCards Identifiers for ACSF2 Gene

  • GC17P045859
  • GC17P048503
  • GC17P043871

Summaries for ACSF2 Gene

GeneCards Summary for ACSF2 Gene

ACSF2 (Acyl-CoA Synthetase Family Member 2) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is ACSM2B.

UniProtKB/Swiss-Prot for ACSF2 Gene

  • Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSF2 Gene

Genomics for ACSF2 Gene

Regulatory Elements for ACSF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACSF2 Gene

50,426,158 bp from pter
50,474,845 bp from pter
48,688 bases
Plus strand

Genomic View for ACSF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSF2 Gene

Proteins for ACSF2 Gene

  • Protein details for ACSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-CoA synthetase family member 2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DFQ6
    • B4DHT5
    • B4DUF5
    • Q9H7G2

    Protein attributes for ACSF2 Gene

    615 amino acids
    Molecular mass:
    68125 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACSF2 Gene


neXtProt entry for ACSF2 Gene

Proteomics data for ACSF2 Gene at MOPED

Post-translational modifications for ACSF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ACSF2 Gene

Gene Families for ACSF2 Gene

  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96CM8
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSF2: view

Function for ACSF2 Gene

Molecular function for ACSF2 Gene

UniProtKB/Swiss-Prot Function: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
UniProtKB/Swiss-Prot Induction: By PPARG.

Enzyme Numbers (IUBMB) for ACSF2 Gene

Gene Ontology (GO) - Molecular Function for ACSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005515 protein binding IPI 21516116
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with ACSF2: view

Phenotypes for ACSF2 Gene

MGI mutant phenotypes for ACSF2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ACSF2: view

Animal Model Products

CRISPR Products

miRNA for ACSF2 Gene

miRTarBase miRNAs that target ACSF2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACSF2 Gene

Localization for ACSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSF2 Gene


Subcellular locations from

Jensen Localization Image for ACSF2 Gene COMPARTMENTS Subcellular localization image for ACSF2 gene
Compartment Confidence
mitochondrion 3
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ACSF2: view

Pathways for ACSF2 Gene

SuperPathways for ACSF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ACSF2: view

No data available for Pathways by source for ACSF2 Gene

Compounds for ACSF2 Gene

(32) HMDB Compounds for ACSF2 Gene

Compound Synonyms Cas Number PubMed IDs
  • (E)-S-2-decenoate Coenzyme A
  • 2-trans-Dodecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
  • (2E)-Tetradecenoyl-Coenzyme A
genes like me logo Genes that share compounds with ACSF2: view

Transcripts for ACSF2 Gene

Unigene Clusters for ACSF2 Gene

Acyl-CoA synthetase family member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACSF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACSF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3: - - -
SP5: - -
SP6: -

Relevant External Links for ACSF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACSF2 Gene

mRNA expression in normal human tissues for ACSF2 Gene

mRNA differential expression in normal tissues according to GTEx for ACSF2 Gene

This gene is overexpressed in Kidney - Cortex (6.4) and Adrenal Gland (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSF2 Gene

SOURCE GeneReport for Unigene cluster for ACSF2 Gene Hs.288959

genes like me logo Genes that share expressions with ACSF2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ACSF2 Gene

Orthologs for ACSF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACSF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACSF2 35
  • 99.43 (n)
  • 99.06 (a)
ACSF2 36
  • 99 (a)
(Bos Taurus)
Mammalia ACSF2 35
  • 87.15 (n)
  • 84.88 (a)
ACSF2 36
  • 85 (a)
(Canis familiaris)
Mammalia ACSF2 35
  • 86.02 (n)
  • 81.79 (a)
ACSF2 36
  • 82 (a)
(Mus musculus)
Mammalia Acsf2 35
  • 82.55 (n)
  • 78.86 (a)
Acsf2 16
Acsf2 36
  • 79 (a)
(Monodelphis domestica)
Mammalia ACSF2 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Acsf2 35
  • 82.82 (n)
  • 80 (a)
(Gallus gallus)
Aves ACSF2 35
  • 66.43 (n)
  • 63.67 (a)
ACSF2 36
  • 58 (a)
(Anolis carolinensis)
Reptilia ACSF2 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16511 35
tropical clawed frog
(Silurana tropicalis)
Amphibia acsf2 35
  • 62.66 (n)
  • 59.86 (a)
(Danio rerio)
Actinopterygii acsf2 35
  • 60.62 (n)
  • 57.17 (a)
acsf2 36
  • 55 (a)
wufi49b09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008557 35
  • 52.5 (n)
  • 42.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12512 35
  • 52.62 (n)
  • 41.05 (a)
CG12512 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea acs-1 35
  • 50.85 (n)
  • 45.64 (a)
acs-1 36
  • 41 (a)
acs-10 36
  • 22 (a)
acs-12 36
  • 18 (a)
acs-14 36
  • 26 (a)
acs-2 36
  • 38 (a)
acs-6 36
  • 22 (a)
acs-7 36
  • 25 (a)
acs-9 36
  • 24 (a)
mec-18 36
  • 18 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06063 35
  • 48.77 (n)
  • 35.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for ACSF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACSF2 Gene

Gene Tree for ACSF2 (if available)
Gene Tree for ACSF2 (if available)

Paralogs for ACSF2 Gene

Paralogs for ACSF2 Gene

genes like me logo Genes that share paralogs with ACSF2: view

Variants for ACSF2 Gene

Sequence variations from dbSNP and Humsavar for ACSF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7627 -- 50,474,793(+) CCCCT(C/G)TCTGT utr-variant-3-prime, nc-transcript-variant
rs1010319 -- 50,429,346(-) AAATC(A/T)GTCAG intron-variant
rs1052585 -- 50,474,648(+) CAGTT(C/T)TGAGC utr-variant-3-prime, nc-transcript-variant
rs1870582 -- 50,451,490(+) tgtca(C/T)ccagg intron-variant
rs2107573 -- 50,435,118(-) ccgag(A/G)cgggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSF2 Gene

Variant ID Type Subtype PubMed ID
nsv833476 CNV Loss 17160897
nsv2080 CNV Loss 18451855
dgv3228n71 CNV Gain 21882294
nsv908600 CNV Gain 21882294
nsv2081 CNV Loss 18451855

Relevant External Links for ACSF2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSF2 Gene

Disorders for ACSF2 Gene

Relevant External Links for ACSF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACSF2: view

No data available for UniProtKB/Swiss-Prot for ACSF2 Gene

Publications for ACSF2 Gene

  1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Identification of novel PPARgamma target genes in primary human adipocytes. (PMID: 16380219) Perera R.J. … Dean N.M. (Gene 2006) 3 4
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for ACSF2 Gene

Sources for ACSF2 Gene

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