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Aliases for ACSBG2 Gene

Aliases for ACSBG2 Gene

  • Acyl-CoA Synthetase Bubblegum Family Member 2 2 3 4 5
  • Bubblegum-Related Protein 3 4
  • PRTD-NY3 3 4
  • BGR 3 4
  • Testicular Tissue Protein Li 8 3
  • Bubblegum Related Protein 2
  • EC 6.2.1.3 4
  • PRTDNY3 3
  • BRGL 3

External Ids for ACSBG2 Gene

Previous GeneCards Identifiers for ACSBG2 Gene

  • GC19P006087
  • GC19P005894

Summaries for ACSBG2 Gene

GeneCards Summary for ACSBG2 Gene

ACSBG2 (Acyl-CoA Synthetase Bubblegum Family Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include long-chain fatty acid-CoA ligase activity and acyl-CoA hydrolase activity. An important paralog of this gene is ENSG00000281938.

UniProtKB/Swiss-Prot for ACSBG2 Gene

  • Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.

Gene Wiki entry for ACSBG2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSBG2 Gene

Genomics for ACSBG2 Gene

Regulatory Elements for ACSBG2 Gene

Genomic Location for ACSBG2 Gene

Chromosome:
19
Start:
6,135,247 bp from pter
End:
6,193,103 bp from pter
Size:
57,857 bases
Orientation:
Plus strand

Genomic View for ACSBG2 Gene

Genes around ACSBG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSBG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSBG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSBG2 Gene

Proteins for ACSBG2 Gene

  • Protein details for ACSBG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FVE4-ACBG2_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase ACSBG2
    Protein Accession:
    Q5FVE4
    Secondary Accessions:
    • B3KSF2
    • Q6UWJ3
    • Q7Z5A0
    • Q8WW03
    • Q96M36
    • Q9BYZ3
    • Q9H0C4

    Protein attributes for ACSBG2 Gene

    Size:
    666 amino acids
    Molecular mass:
    74354 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAE12157.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSBG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSBG2 Gene

Proteomics data for ACSBG2 Gene at MOPED

Post-translational modifications for ACSBG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ACSBG2 Gene

Domains & Families for ACSBG2 Gene

Gene Families for ACSBG2 Gene

Protein Domains for ACSBG2 Gene

Suggested Antigen Peptide Sequences for ACSBG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5FVE4

UniProtKB/Swiss-Prot:

ACBG2_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
genes like me logo Genes that share domains with ACSBG2: view

Function for ACSBG2 Gene

Molecular function for ACSBG2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
UniProtKB/Swiss-Prot Function:
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.

Enzyme Numbers (IUBMB) for ACSBG2 Gene

Gene Ontology (GO) - Molecular Function for ACSBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with ACSBG2: view
genes like me logo Genes that share phenotypes with ACSBG2: view

Animal Models for ACSBG2 Gene

MGI Knock Outs for ACSBG2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACSBG2

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ACSBG2 Gene

Localization for ACSBG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSBG2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSBG2 Gene COMPARTMENTS Subcellular localization image for ACSBG2 gene
Compartment Confidence
cytosol 5
mitochondrion 5
cytoskeleton 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACSBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ACSBG2: view

Pathways & Interactions for ACSBG2 Gene

genes like me logo Genes that share pathways with ACSBG2: view

Interacting Proteins for ACSBG2 Gene

Gene Ontology (GO) - Biological Process for ACSBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0030154 cell differentiation IEA --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ACSBG2: view

No data available for SIGNOR curated interactions for ACSBG2 Gene

Drugs & Compounds for ACSBG2 Gene

(6) Drugs for ACSBG2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Propionyl-CoA Experimental Pharma 0

(32) Additional Compounds for ACSBG2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSBG2: view

Transcripts for ACSBG2 Gene

Unigene Clusters for ACSBG2 Gene

Acyl-CoA synthetase bubblegum family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSBG2 Gene

No ASD Table

Relevant External Links for ACSBG2 Gene

GeneLoc Exon Structure for
ACSBG2
ECgene alternative splicing isoforms for
ACSBG2

Expression for ACSBG2 Gene

mRNA expression in normal human tissues for ACSBG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACSBG2 Gene

This gene is overexpressed in Testis (x50.1).

Protein differential expression in normal tissues from HIPED for ACSBG2 Gene

This gene is overexpressed in Heart (28.2), Breast (28.2), and Testis (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACSBG2 Gene



SOURCE GeneReport for Unigene cluster for ACSBG2 Gene Hs.465720

mRNA Expression by UniProt/SwissProt for ACSBG2 Gene

Q5FVE4-ACBG2_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with ACSBG2: view

Protein tissue co-expression partners for ACSBG2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ACSBG2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACSBG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACSBG2 35
  • 78.75 (n)
  • 72.96 (a)
ACSBG2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSBG2 35
  • 81.15 (n)
  • 73.15 (a)
ACSBG2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsbg2 35
  • 72.99 (n)
  • 69.65 (a)
Acsbg2 16
Acsbg2 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACSBG2 35
  • 99.05 (n)
  • 98.8 (a)
ACSBG2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsbg2 35
  • 74.56 (n)
  • 71.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ACSBG2 35
  • 62.03 (n)
  • 58.58 (a)
ACSBG2 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6052 35
acsbg2 35
  • 61.61 (n)
  • 59.69 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53673 35
zebrafish
(Danio rerio)
Actinopterygii acsbg2 35
  • 62.59 (n)
  • 59.87 (a)
acsbg2 36
  • 48 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3252 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008596 35
  • 53.05 (n)
  • 44.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta bgm 35
  • 51.5 (n)
  • 43.46 (a)
bgm 36
  • 41 (a)
ManyToMany
CG4500 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acs-18 36
  • 20 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA2 36
  • 19 (a)
OneToMany
Species with no ortholog for ACSBG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACSBG2 Gene

ENSEMBL:
Gene Tree for ACSBG2 (if available)
TreeFam:
Gene Tree for ACSBG2 (if available)

Paralogs for ACSBG2 Gene

Paralogs for ACSBG2 Gene

(1) SIMAP similar genes for ACSBG2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ACSBG2 Gene

genes like me logo Genes that share paralogs with ACSBG2: view

Variants for ACSBG2 Gene

Sequence variations from dbSNP and Humsavar for ACSBG2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_038317 -
VAR_038318 -
VAR_038319 -
VAR_038320 -
VAR_038321 -

Structural Variations from Database of Genomic Variants (DGV) for ACSBG2 Gene

Variant ID Type Subtype PubMed ID
esv2543418 CNV Deletion 19546169
esv2718060 CNV Deletion 23290073
esv2154244 CNV Deletion 18987734
esv2718061 CNV Deletion 23290073
esv3187 CNV Deletion 18987735
esv2458578 CNV Deletion 19546169
esv2675978 CNV Deletion 23128226
nsv910910 CNV Loss 21882294
nsv910911 CNV Loss 21882294

Variation tolerance for ACSBG2 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACSBG2 Gene

HapMap Linkage Disequilibrium report
ACSBG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSBG2 Gene

Disorders for ACSBG2 Gene

Relevant External Links for ACSBG2

Genetic Association Database (GAD)
ACSBG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACSBG2

No disorders were found for ACSBG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSBG2 Gene

Publications for ACSBG2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis. (PMID: 16762313) Fraisl P. … Berger J. (Arch. Biochem. Biophys. 2006) 3 23
  3. Identification and characterization of the BGR-like gene with a potential role in human testicular development/spermatogenesis. (PMID: 15685348) Zheng Y. … Sha J.-H. (Asian J. Androl. 2005) 3 23
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ACSBG2 Gene

Sources for ACSBG2 Gene

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