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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACSBG1 Gene

protein-coding GIFtS: 59
GCID: GC15M078460

acyl-CoA synthetase bubblegum family member 1

Explore 4 diseases affiliated with
ACSBG1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acyl-CoA Synthetase Bubblegum Family Member 1¹ ² ³		MGC14352¹
BGM¹ ² ³		BG²
BG1¹ ²		GR-LACS²
KIAA0631¹ ³		Bubblegum¹
HBG1¹		Lipidosin³
HsBG¹		Long-Chain-Fatty-Acid--CoA Ligase ACSBG1²
LPD² ³		Very Long-Chain Acyl-CoA Synthetase²
EC 6.2.1.3³ ⁸		Lipidosin³
FLJ30320¹		HsBGM¹

External Ids:	HGNC: 29567¹	Entrez Gene: 23205²	Ensembl: ENSG00000103740⁷	OMIM: 614362⁵	UniProtKB: Q96GR2³

Export aliases for ACSBG1 gene to outside databases

Previous GC identifers: GC15M076247 GC15M055220

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACSBG1:

The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central

role in brain very long-chain fatty acids metabolism and myelinogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2

Function: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via

beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however,

the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated

fatty acids

Gene Wiki entry for ACSBG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACSBG1 gene promoter:
Spz1 FOXD1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) HNF-4alpha2 POU3F2 HNF-4alpha1 Zic1 IRF-7A LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACSBG1 promoter sequence

Search SABiosciences Chromatin IP Primers for ACSBG1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSBG1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23-q24 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q23-q24

ACSBG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSBG1 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M078460: view genomic region (about GC identifiers)

Start:	78,459,810 bp from pter	End:	78,538,030 bp from pter
Size:	78,221 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2 (See protein sequence)

Recommended Name: Long-chain-fatty-acid--CoA ligase ACSBG1

Size: 724 amino acids; 81290 Da

Subcellular location: Cytoplasm. Cytoplasmic vesicle (By similarity). Microsome (By similarity). Endoplasmic reticulum

(By similarity)

Sequence caution: Sequence=BAA31606.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B2RB61 O75126 Q76N27 Q9HC26

Explore the universe of human proteins at neXtProt for ACSBG1: NX_Q96GR2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96GR2

4/13 DME Specific Peptides for ACSBG1 (Q96GR2) (see all 13)

VPRVWEK

RLADYLVLA

IDSFYQEQK

LPHLKAVVIY

ACSBG1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001186306.1 NP_055977.3

ENSEMBL proteins:

ENSP00000258873 ENSP00000453605 ENSP00000453451 ENSP00000453447 ENSP00000453585

ENSP00000454188 ENSP00000453547 ENSP00000453800 ENSP00000439955

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACSBG1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	10954726
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005792	microsome	--	--
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	--

ACSBG1 for ontologies About GeneDecksing

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	Uscn Antibodies for ACSBG1
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	Uscn ELISAs and CLIAs for ACSBG1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACSBG1 for domains About GeneDecksing

2 InterPro domains/families:

IPR000873 AMP-dep_Synth/Lig

IPR020845 AMP-binding_CS

Graphical View of Domain Structure for InterPro Entry Q96GR2

ProtoNet protein and cluster: Q96GR2

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2

Function: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via

beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however,

the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated

fatty acids

Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA

Enzyme Number (IUBMB): EC 6.2.1.3¹ ²

miRNA Products:		OriGene 3'-UTR Clone: ACSBG1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSBG1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSBG1:
		hsa-miR-3671 hsa-miR-607 hsa-miR-3622b-3p hsa-miR-127-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ACSBG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ACSBG1

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		Search LifeMap BioReagents cell lines for ACSBG1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSBG1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004467	long-chain fatty acid-CoA ligase activity	IDA	10954726
GO:0005524	ATP binding	IEA	--
GO:0031957	very long-chain fatty acid-CoA ligase activity	IDA	10954726

ACSBG1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Acsbg1^tm1Mld for ACSBG1
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Acsbg1):

endocrine/exocrine gland

homeostasis/metabolism

reproductive system

ACSBG1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

fatty acid alpha-oxidation II

	fatty acid alpha-oxidation II	1.00			stearate biosynthesis I (animals)	0.43
	fatty acid activation	0.67			fatty acid beta-oxidation I	0.39

PPAR signaling pathway

PPAR signaling pathway

1.00

eicosapentaenoate biosynthesis II (metazoa)

gamma-linolenate biosynthesis II (animals)

0.69

Metabolism

Metabolic pathways

0.38

Fatty Acid Beta Oxidation

Fatty acid metabolism

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

5 BioSystems Pathways for ACSBG1

	stearate biosynthesis I (animals)
	fatty acid alpha-oxidation II
	gamma-linolenate biosynthesis II (animals)
	fatty acid beta-oxidation I
	fatty acid activation

4 Kegg Pathways (Kegg details for ACSBG1):

	Fatty acid metabolism
	Metabolic pathways
	PPAR signaling pathway
	Adipocytokine signaling pathway

ACSBG1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ACSBG1

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/27 Interacting proteins for ACSBG1 (Q96GR2^{2, 3} ENSP00000258873⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GSK3B	P49841²^,³	MINT-8256844 I2D: score=2
APPBP2	Q92624³	I2D: score=1
YWHAB	P31946³	I2D: score=1
ACADM	ENSP00000409612⁴	STRING: ENSP00000409612
ACADVL	ENSP00000325395⁴	STRING: ENSP00000325395

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000038	very long-chain fatty acid metabolic process	IDA	10954726
GO:0001552	ovarian follicle atresia	IEA	--
GO:0001676	long-chain fatty acid metabolic process	IDA	10954726
GO:0042552	myelination	NAS	10954726
GO:0051384	response to glucocorticoid stimulus	IEA	--

ACSBG1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACSBG1

10/34 HMDB Compounds for ACSBG1 (see all 34) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
20-COOH-leukotriene E4	20-COOH-LTE4 (see all 3)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
6,9,12,15,18,21-Tetracosahexaenoic acid	all-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)	--	--

1 DrugBank Compound for ACSBG1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about ACSBG1 / ACBG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACSBG1 gene (2 alternative transcripts):

NM_001199377.1 NM_015162.4

Unigene Cluster for ACSBG1:

Acyl-CoA synthetase bubblegum family member 1

Hs.655760 [show with all ESTs]

Unigene Representative Sequence: NM_015162

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000258873(uc010umw.2 uc002bdh.3 uc010umx.2 uc010umy.2)

ENST00000560124 ENST00000560817 ENST00000560183 ENST00000558301 ENST00000559707

ENST00000558728 ENST00000557935 ENST00000559114 ENST00000559241 ENST00000558130

ENST00000558828 ENST00000558793 ENST00000559713 ENST00000541759

miRNA Products:		OriGene 3'-UTR Clone: ACSBG1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSBG1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSBG1:
		hsa-miR-3671 hsa-miR-607 hsa-miR-3622b-3p hsa-miR-127-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ACSBG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSBG1

Additional cDNA sequence:

AF070624.1 AF179481.1 AK054882.1 AK294202.1 AK295269.1 AK299597.1 AK314508.1 BC009289.2

BC040252.1

9 DOTS entries:

DT.100824942 DT.95282903 DT.86998295 DT.121032145 DT.95258938 DT.121032179 DT.95258936 DT.97766092

DT.101971920

24/83 AceView cDNA sequences (see all 83):

BG741938 NM_015162 BG743510 BI756677 AF179481 AI936780 BG697616 AA779914

BC040252 CF454811 AK054882 AI826060 CD243802 AA835913 BQ680060 BG697707

AI085608 Z45459 BF689600 AI094662 BG742700 BF935029 BG742897 AI094858

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACSBG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAACTGACT

About this image

ACSBG1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Mature follicles (In-vitro growth and ...)

See ACSBG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACSBG1

SOURCE GeneReport for Unigene cluster: Hs.655760

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2

Tissue specificity: Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all

regions of brain except pituitary

SABiosciences Expression via Pathway-Focused PCR Array including ACSBG1:

Fatty Acid Metabolism in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSBG1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSBG1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSBG1 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACSBG1¹	acyl-CoA synthetase bubblegum family member 1	67.87(n) 69.57(a)		415361 XM_413747.2 XP_413747.2
lizard (Anolis carolinensis)	Reptilia	ACSBG1⁶	--	68(a)	1 ↔ 1	GL343486.1(111006-120113)
zebrafish (Danio rerio)	Actinopterygii	LOC100006023¹	long-chain-fatty-acid--CoA ligase ACSBG1-like	61.72(n) 61.88(a)		100006023 XM_001344868.2 XP_001344904.2
fruit fly (Drosophila melanogaster)	Insecta	bgm⁶ CG4500⁶	--	39(a) 37(a)	many ↔ many many ↔ many	2L(14013747-14019328) 2L(14027010-14029368)
thale cress (Arabidopsis thaliana)	eudicotyledons	AAE15⁶ AAE16⁶	long-chain acyl-CoA synthetase AMP-dependent synthetase and ligase family protein...	20(a) 19(a)	possible ortholog possible ortholog	4(8111962-8118160) 3(8575167-8581112)
rice (Oryza sativa)	Liliopsida	--	AMP-binding enzyme, putative, expressed	19(a)	possible ortholog	3(35542033-35550917)

ENSEMBL Gene Tree for ACSBG1 (if available)
TreeFam Gene Tree for ACSBG1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ACSBG1 gene

ACSL3² ACSL6² ACSL4² ACSBG2² ACSL1² ACSL5²

1 SIMAP similar gene for ACSBG1 using alignment to 8 protein entries: ACBG1_HUMAN (see all proteins):

ACSBG2

ACSBG1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ACSBG1
PGOHUM00000262066

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3825847^1,2	C,F,H,	--	78463486(-)	`AGTTCC/TAGGTA`	2	--	ut3¹ ese³		32		EA NS NA WA	4504
rs149534543^1,2		--	78463599(+)	`TGAAGC/GTTCTT`	2	--	ut3¹		0	--	--	--	--
rs199991915^1,2		--	78463739(+)	`GGCTCA/GGAACG`	2	--	ut3¹		0	--	--	--	--
rs147470279^1,2	C,	--	78463772(+)	`CTGCAA/GGCATA`	2	--	ut3¹		0	--	--	--	--
rs201874784^1,2		--	78463798(+)	`TTTTGC/TTCTTG`	4	E	syn¹		0	--	--	--	--
rs201136052^1,2		--	78463874(+)	`GACCTA/TAAAGG`	2	--	int¹		0	--	--	--	--
rs11638547^1,2	C,F,A,H,	--	78463890(+)	`GAGAAG/TAAATG`	2	--	int¹		29		NA EA NS WA CSA	2722
rs77787593^1,2	C,	--	78463910(+)	`CAGGCT/CCTGAG`	2	--	int¹		1		EA	120
rs139852452^1,2		--	78464015(+)	`CAAGAC/TAGTGA`	2	--	int¹		0	--	--	--	--
rs145485376^1,2		--	78464129(+)	`AGGTTA/GTAAAA`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ACSBG1 (78459810 - 78538030 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACSBG1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ACSBG1 for disorders           About GeneDecksing

OMIM gene information: 614362    OMIM disorders: --

4 diseases for ACSBG1:    About MalaCards

adrenoleukodystrophy tuberculosis neuronitis mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for ACSBG1:

Adrenoleukodystrophy

Human Genome Epidemiology (HuGE) Navigator: ACSBG1 (2 documents)

Export disorders for ACSBG1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ACSBG1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ACSBG1)

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world of online information

Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents a new family of proteins capable of activating very long-chain fatty acids. (PubMed id 10954726)^{1, 2, 3} Steinberg S.J....Watkins P.A. (2000)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2, 3} Ishikawa K.... Ohara O. (1998)
The acyl-CoA synthetase 'bubblegum' (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.. (PubMed id 12975357)^{1, 2, 9} Pei Z....Watkins P.A. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. (PubMed id 15464426)^{1, 9} Jia Z....Watkins P.A. (2004)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
A genome-wide association study of Cloninger's temper ament scales: implications for the evolutionary genetics of personality. (PubMed id 20691247)¹ Verweij K.J....Wray N.R. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23205	HGNC: 29567	AceView: BG1	Ensembl:ENSG00000103740	euGenes: HUgn23205
ECgene: ACSBG1	Kegg: 23205	H-InvDB: ACSBG1

(According to HUGE)
About This Section

HUGE: KIAA0631

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ACSBG1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACSBG1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACSBG1 gene:
Search GeneIP for patents involving ACSBG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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acyl-CoA synthetase bubblegum family member 1

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ACSBG1 Gene

acyl-CoA synthetase bubblegum family member 1

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