Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ACSBG1 Gene

protein-coding   GIFtS: 62
GCID: GC15M078460

Acyl-CoA Synthetase Bubblegum Family Member 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Acyl-CoA Synthetase Bubblegum Family Member 11 2 3     BG12 5
bubblegum1 2     KIAA06313 5
lipidosin1 2     GR-LACS2
Very Long-Chain Acyl-CoA Synthetase1 2     Long-Chain-Fatty-Acid--CoA Ligase ACSBG12
BGM2 3     Lipidosin3
LPD2 3     hBG13
EC 6.2.1.33 8     hsBG3
BG2 5     hsBGM3

External Ids:    HGNC: 295671   Entrez Gene: 232052   Ensembl: ENSG000001037407   OMIM: 6143625   UniProtKB: Q96GR23   
ORGUL members:         

Export aliases for ACSBG1 gene to outside databases

Previous GC identifers: GC15M076247 GC15M055220


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ACSBG1 Gene:
The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a
central role in brain very long-chain fatty acids metabolism and myelinogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACSBG1 Gene:
ACSBG1 (acyl-CoA synthetase bubblegum family member 1) is a protein-coding gene. GO annotations related to this gene include very long-chain fatty acid-CoA ligase activity and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL6.

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2
Function: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via
beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids;
however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and
polyunsaturated fatty acids

Gene Wiki entry for ACSBG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACSBG1 gene promoter:
         Spz1   FOXD1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   HNF-4alpha2   POU3F2   HNF-4alpha1   Zic1   IRF-7A   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACSBG1 promoter sequence
   Search Chromatin IP Primers for ACSBG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACSBG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23-q24   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q23-q24

ACSBG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSBG1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M078460:  view genomic region     (about GC identifiers)

Start:
78,459,810 bp from pter      End:
78,538,030 bp from pter
Size:
78,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2 (See protein sequence)
Recommended Name: Long-chain-fatty-acid--CoA ligase ACSBG1  
Size: 724 amino acids; 81290 Da
Sequence caution: Sequence=BAA31606.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RB61 O75126 Q76N27 Q9HC26

Explore the universe of human proteins at neXtProt for ACSBG1: NX_Q96GR2

Explore proteomics data for ACSBG1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACSBG1 (Q96GR2) (see all 13)
     VPRVWEK  RLADYLVLA  IDSFYQEQK  LPHLKAVVIY 


    See ACSBG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186306.1  NP_055977.3  

    ENSEMBL proteins: 
     ENSP00000258873   ENSP00000453605   ENSP00000453451   ENSP00000453447   ENSP00000453585  
     ENSP00000454188   ENSP00000453547   ENSP00000453800   ENSP00000439955  

    ACSBG1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACSBG1
    OriGene Protein Over-expression Lysate for ACSBG1
    OriGene MassSpec for ACSBG1
    OriGene Custom Protein Services for ACSBG1
    GenScript Custom Purified and Recombinant Proteins Services for ACSBG1
    Novus Biologicals ACSBG1 Protein
    Novus Biologicals ACSBG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACSBG1

     
    Search eBioscience for Proteins for ACSBG1 

     
    antibodies-online proteins for ACSBG1 (6 products) 

     
    Search antibodies-online for peptides for ACSBG1

    ACSBG1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACSBG1
    OriGene Custom Antibody Services for ACSBG1
    Novus Biologicals ACSBG1 Antibodies
    Abcam antibodies for ACSBG1
    Cloud-Clone Corp. Antibodies for ACSBG1
    Search ThermoFisher Antibodies for ACSBG1
    antibodies-online antibodies for ACSBG1 (13 products) 

    ACSBG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACSBG1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACSBG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACSBG1
    Cloud-Clone Corp. CLIAs for ACSBG1
    Search eBioscience for ELISAs for ACSBG1 
    antibodies-online kits for ACSBG1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ACS: Acyl-CoA synthetase family

    2 InterPro protein domains:
     IPR020845 AMP-binding_CS
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry Q96GR2

    ProtoNet protein and cluster: Q96GR2

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily


    Find genes that share domains with ACSBG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACBG1_HUMAN, Q96GR2
    Function: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via
    beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids;
    however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and
    polyunsaturated fatty acids
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA

         Enzyme Number (IUBMB): EC 6.2.1.31 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IDA10954726
    GO:0005524ATP binding IEA--
    GO:0031957very long-chain fatty acid-CoA ligase activity IDA10954726
         
    Find genes that share ontologies with ACSBG1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acsbg1):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with ACSBG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Acsbg1tm1Mld for ACSBG1

       genOway: Develop your customized and physiologically relevant rodent model for ACSBG1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ACSBG1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ACSBG1:
    hsa-miR-3671 hsa-miR-607 hsa-miR-3622b-3p hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidACSBG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACSBG1
    Predesigned siRNA for gene silencing in human, mouse, rat ACSBG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACSBG1

    Clone
    Products:
         
    OriGene clones in human, mouse for ACSBG1 (see all 6)
    OriGene ORF clones in mouse, rat for ACSBG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACSBG1 (NM_001199377)
    Sino Biological Human cDNA Clone for ACSBG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSBG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSBG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACSBG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACSBG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSBG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ACBG1_HUMAN, Q96GR2: Cytoplasm. Cytoplasmic vesicle (By similarity). Microsome (By similarity). Endoplasmic
    reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum2
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10954726
    GO:0005783endoplasmic reticulum IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    Find genes that share ontologies with ACSBG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ACSBG1 About    
    See pathways by source

    SuperPathContained pathways About
    1PPAR signaling pathway
    fatty acid beta-oxidation VI (peroxisome)0.00
    PPAR signaling pathway
    2stearate biosynthesis I (animals)
    stearate biosynthesis I (animals)0.35
    fatty acid beta-oxidation I0.30
    gamma-linolenate biosynthesis II (animals)0.35
    fatty acid activation0.00
    3Fatty acid metabolism
    Fatty acid metabolism0.42
    Fatty acid degradation0.42
    4Metabolism
    Metabolic pathways0.38
    5Adipocytokine signaling pathway
    Adipocytokine signaling pathway


    Find genes that share SuperPaths with ACSBG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for ACSBG1
        stearate biosynthesis I (animals)
    gamma-linolenate biosynthesis II (animals)
    fatty acid beta-oxidation VI (peroxisome)
    fatty acid beta-oxidation I
    fatty acid activation



    5 Kegg Pathways  (Kegg details for ACSBG1):
        Fatty acid degradation
    Metabolic pathways
    Fatty acid metabolism
    PPAR signaling pathway
    Adipocytokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including ACSBG1: 
              Fatty Acid Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ACSBG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACSBG1 (Q96GR22, 3 ENSP000002588734) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8256844 I2D: score=2 
    APPBP2Q926243I2D: score=1 
    YWHABP319463I2D: score=1 
    ACADLENSP000002337104STRING: ENSP00000233710
    ACADMENSP000004096124STRING: ENSP00000409612
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process IDA10954726
    GO:0001552ovarian follicle atresia IEA--
    GO:0001676long-chain fatty acid metabolic process IDA10954726
    GO:0008152metabolic process ----
    GO:0042552myelination NAS10954726

    Find genes that share ontologies with ACSBG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACSBG1 (ACBG1)

    Selected HMDB Compounds for ACSBG1 (see all 34)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----

    1 DrugBank Compound for ACSBG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ACSBG1 gene (2 alternative transcripts): 
    NM_001199377.1  NM_015162.4  

    Unigene Cluster for ACSBG1:

    Acyl-CoA synthetase bubblegum family member 1
    Hs.655760  [show with all ESTs]
    Unigene Representative Sequence: NM_015162
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258873(uc010umw.2 uc002bdh.3 uc010umx.2 uc010umy.2)
    ENST00000560124 ENST00000560817 ENST00000560183 ENST00000558301 ENST00000559707
    ENST00000558728 ENST00000557935 ENST00000559114 ENST00000559241 ENST00000558130
    ENST00000558828 ENST00000558793 ENST00000559713 ENST00000541759
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACSBG1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ACSBG1:
    hsa-miR-3671 hsa-miR-607 hsa-miR-3622b-3p hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidACSBG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACSBG1
    Predesigned siRNA for gene silencing in human, mouse, rat ACSBG1
    Clone
    Products:
         
    OriGene clones in human, mouse for ACSBG1 (see all 6)
    OriGene ORF clones in mouse, rat for ACSBG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACSBG1 (NM_001199377)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSBG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSBG1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACSBG1
    OriGene qSTAR qPCR primer pairs in human, mouse for ACSBG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACSBG1
      QuantiTect SYBR Green Assays in human, mouse, rat ACSBG1
      QuantiFast Probe-based Assays in human, mouse, rat ACSBG1

    Additional mRNA sequence: 

    AF070624.1 AF179481.1 AK054882.1 AK294202.1 AK295269.1 AK299597.1 AK314508.1 BC009289.2 
    BC040252.1 

    9 DOTS entries:

    DT.100824942  DT.95282903  DT.86998295  DT.121032145  DT.95258938  DT.121032179  DT.95258936  DT.97766092 
    DT.101971920 

    Selected AceView cDNA sequences (see all 83):

    BG741938 BG743510 AI936780 BG697616 AF179481 CD243802 AI826060 AK054882 
    NM_015162 CF454811 BI756677 BC040252 AA779914 BE156064 BI758180 BQ680060 
    BG698315 AI589886 BG697707 BC009289 BI829088 AI096435 AB014531 BG696366 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ACSBG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAACTGACT
    ACSBG1 Expression
    About this image


    ACSBG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Ovary (Reproductive System)
             Mature follicles
     
     Adipose (Muscoskeletal System)
             Adipocyte-like cells
    ACSBG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACSBG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655760

    UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2
    Tissue specificity: Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in
    all regions of brain except pituitary

        Pathway & Disease-focused RT2 Profiler PCR Array including ACSBG1: 
              Fatty Acid Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACSBG1
    OriGene qSTAR qPCR primer pairs in human, mouse for ACSBG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACSBG1
    QuantiTect SYBR Green Assays in human, mouse, rat ACSBG1
    QuantiFast Probe-based Assays in human, mouse, rat ACSBG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSBG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ACSBG1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acsbg11 , 5 acyl-CoA synthetase bubblegum family member 11, 5 84.95(n)1
    86.81(a)1
      9 (29.70 cM)5
    941801  NM_053178.21  NP_444408.11 
     546048775 
    chicken
    (Gallus gallus)
    Aves ACSBG11 acyl-CoA synthetase bubblegum family member 1 67.39(n)
    68.7(a)
      415361  XM_413747.3  XP_413747.3 
    lizard
    (Anolis carolinensis)
    Reptilia ACSBG16
    acyl-CoA synthetase bubblegum family member 1
    68(a)
    1 ↔ 1
    GL343486.1(111006-120976)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000060231 long-chain-fatty-acid--CoA ligase ACSBG1-like 61.72(n)
    61.88(a)
      100006023  XM_001344868.3  XP_001344904.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta bgm6
    CG45006
    --
    40(a)
    37(a)
    many ↔ many
    many ↔ many
    2L(14013747-14019328)
    2L(14027010-14029368)
    worm
    (Caenorhabditis elegans)
    Secernentea acs-36
    Protein ACS-3 (acs-3) mRNA, complete cds
    21(a)
    many ↔ many
    V(1969541-1974515) WBGene00020343
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAA26
    Medium chain fatty acyl-CoA synthetase, activates ...
    19(a)
    1 → many
    V(184541-186775) YER015W


    ENSEMBL Gene Tree for ACSBG1 (if available)
    TreeFam Gene Tree for ACSBG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ACSBG1 gene
    ACSL62  ACSBG22  ACSL12  ACSL52  
    1 SIMAP similar gene for ACSBG1 using alignment to 8 protein entries:     ACBG1_HUMAN (see all proteins):
    ACSBG2

    Find genes that share paralogs with ACSBG1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ACSBG1
    PGOHUM00000262066


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ACSBG1 (see all 1399)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38258471,2
    C,F,H--78463486(-) AGTTCC/TAGGTA 2 -- ut31 ese332Minor allele frequency- T:0.06EA NS NA WA 4504
    rs1495345431,2
    --78463599(+) TGAAGC/GTTCTT 2 -- ut310--------
    rs1999919151,2
    C--78463739(+) GGCTCA/GGAACG 2 -- ut310--------
    rs1474702791,2
    C--78463772(+) CTGCAA/GGCATA 2 -- ut310--------
    rs2018747841,2
    --78463798(+) TTTTGC/TTCTTG 4 E syn10--------
    rs2011360521,2
    --78463874(+) GACCTA/TAAAGG 2 -- int10--------
    rs116385471,2
    C,F,A,H--78463890(+) GAGAAG/TAAATG 2 -- int129Minor allele frequency- T:0.22NA EA NS WA CSA 2722
    rs777875931,2
    C--78463910(+) CAGGCT/CCTGAG 2 -- int11Minor allele frequency- C:0.01EA 120
    rs1398524521,2
    --78464015(+) CAAGAC/TAGTGA 2 -- int10--------
    rs1454853761,2
    --78464129(+) AGGTTA/GTAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ACSBG1 (78459810 - 78538030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ACSBG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904430CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACSBG1
    DNA2.0 Custom Variant and Variant Library Synthesis for ACSBG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614362    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ACSBG1:
    Adrenoleukodystrophy

    Find genes that share disorders with ACSBG1           About GenesLikeMe

    Genetic Association Database (GAD): ACSBG1
    Human Genome Epidemiology (HuGE) Navigator: ACSBG1 (2 documents)

    Export disorders for ACSBG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ACSBG1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ACSBG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents a new family of proteins capable of activating very long-chain fatty acids. (PubMed id 10954726)1, 2, 3 Steinberg S.J....Watkins P.A. (J. Biol. Chem. 2000)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    3. The acyl-CoA synthetase 'bubblegum' (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. (PubMed id 12975357)1, 2, 9 Pei Z.... Watkins P.A. (J. Biol. Chem. 2003)
    4. A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. (PubMed id 20691247)1, 4 Verweij K.J....Wray N.R. (Biol Psychol 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. (PubMed id 15464426)1, 9 Jia Z....Watkins P.A. (Mol. Genet. Metab. 2004)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23205 HGNC: 29567 AceView: BG1 Ensembl:ENSG00000103740 euGenes: HUgn23205
    ECgene: ACSBG1 Kegg: 23205 H-InvDB: ACSBG1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0631

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ACSBG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ACSBG1 gene:
    Search GeneIP for patents involving ACSBG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACSBG1   OriGene RNAi products in human, mouse, rat for ACSBG1  
     OriGene qPCR primer pairs and template standards for ACSBG1   OriGene Protein Over-expression Lysate for ACSBG1  
     OriGene MassSpec for ACSBG1   OriGene clones in human, mouse for ACSBG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACSBG1   OriGene Purified Protein for ACSBG1  
     OriGene ORF clones in mouse, rat for ACSBG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACSBG1   OriGene Custom Protein Services for ACSBG1  

     
     
     Block miRNA regulation of human, mouse, rat ACSBG1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ACSBG1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACSBG1 Predesigned siRNA for gene silencing in human, mouse, rat ACSBG1
     QuantiFast Probe-based Assays in human, mouse, rat ACSBG1 QuantiTect SYBR Green Assays in human, mouse, rat ACSBG1
     PCR Arrays including human, mouse, rat ACSBG1 Search Chromatin IP Primers for ACSBG1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACSBG1  GeneGlobe Interaction Network for ACSBG1
     Regulatory tfbs in ACSBG1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ACSBG1 GenScript cDNA clones with any tag delivered in your preferred vector for ACSBG1
     GenScript Custom Assay Services for ACSBG1 GenScript Custom overexpressing Cell Line Services for ACSBG1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ACSBG1 (ACBG1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ACSBG1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ACSBG1 antibodies
     ACSBG1 proteins
     ACSBG1 lysates
     Antibodies for ACSBG1
     See all of Abcam's Antibodies, Kits and Proteins for ACSBG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ACSBG1
     Antibodies for ACSBG1
     ELISAs for ACSBG1
     CLIAs for ACSBG1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ACSBG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSBG1
     SwitchGear 3'UTR luciferase reporter plasmids for ACSBG1
     SwitchGear Promoter luciferase reporter plasmids for ACSBG1
     Search ThermoFisher Antibodies for ACSBG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSBG1
     Browse compounds at ApexBio
     Search Addgene for plasmids for ACSBG1
      Search eBioscience for proteins for ACSBG1
      Search eBioscience for elisas for ACSBG1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ACSBG1
     antibodies-online antibodies for ACSBG1 (13 products)
     antibodies-online kits for ACSBG1 (8 products)
      Search antibodies-online for peptides for ACSBG1
     antibodies-online proteins for ACSBG1 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACSBG1 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4