Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACSBG1 Gene

protein-coding   GIFtS: 62
GCID: GC15M078460

Acyl-CoA Synthetase Bubblegum Family Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acyl-CoA Synthetase Bubblegum Family Member 11 2 3     BG12
bubblegum1 2     GR-LACS2
lipidosin1 2     Long-Chain-Fatty-Acid--CoA Ligase ACSBG12
Very Long-Chain Acyl-CoA Synthetase1 2     KIAA06313
BGM2 3     Lipidosin3
LPD2 3     hBG13
EC 6.2.1.33 8     hsBG3
BG2     hsBGM3

External Ids:    HGNC: 295671   Entrez Gene: 232052   Ensembl: ENSG000001037407   OMIM: 6143625   UniProtKB: Q96GR23   

Export aliases for ACSBG1 gene to outside databases

Previous GC identifers: GC15M076247 GC15M055220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACSBG1 Gene:
The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a
central role in brain very long-chain fatty acids metabolism and myelinogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACSBG1 Gene: 
ACSBG1 (acyl-CoA synthetase bubblegum family member 1) is a protein-coding gene. Diseases associated with ACSBG1 include adrenoleukodystrophy, and tuberculosis, and among its related super-pathways are fatty acid activation and eicosapentaenoate biosynthesis II (metazoa). GO annotations related to this gene include very long-chain fatty acid-CoA ligase activity and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL6.

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2
Function: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via
beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids;
however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and
polyunsaturated fatty acids

Gene Wiki entry for ACSBG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACSBG1 gene promoter:
         Spz1   FOXD1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   HNF-4alpha2   POU3F2   HNF-4alpha1   Zic1   IRF-7A   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACSBG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACSBG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSBG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23-q24   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q23-q24

ACSBG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSBG1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M078460:  view genomic region     (about GC identifiers)

Start:
78,459,810 bp from pter      End:
78,538,030 bp from pter
Size:
78,221 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2 (See protein sequence)
Recommended Name: Long-chain-fatty-acid--CoA ligase ACSBG1  
Size: 724 amino acids; 81290 Da
Subcellular location: Cytoplasm. Cytoplasmic vesicle (By similarity). Microsome (By similarity). Endoplasmic
reticulum (By similarity)
Sequence caution: Sequence=BAA31606.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RB61 O75126 Q76N27 Q9HC26

Explore the universe of human proteins at neXtProt for ACSBG1: NX_Q96GR2

Explore proteomics data for ACSBG1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GR2

  • 4/13 DME Specific Peptides for ACSBG1 (Q96GR2) (see all 13)
     VPRVWEK  RLADYLVLA  IDSFYQEQK  LPHLKAVVIY 

    ACSBG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACSBG1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186306.1  NP_055977.3  

    ENSEMBL proteins: 
     ENSP00000258873   ENSP00000453605   ENSP00000453451   ENSP00000453447   ENSP00000453585  
     ENSP00000454188   ENSP00000453547   ENSP00000453800   ENSP00000439955  

    Human Recombinant Protein Products for ACSBG1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACSBG1
    OriGene Protein Over-expression Lysate for ACSBG1
    OriGene MassSpec for ACSBG1 
    OriGene Custom Protein Services for ACSBG1
    GenScript Custom Purified and Recombinant Proteins Services for ACSBG1
    Novus Biologicals ACSBG1 Protein
    Novus Biologicals ACSBG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACSBG1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10954726
    GO:0005783endoplasmic reticulum IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    ACSBG1 for ontologies           About GeneDecksing



    ACSBG1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACSBG1
    OriGene Custom Antibody Services for ACSBG1
    GenScript Custom Superior Antibodies Services for ACSBG1
    Novus Biologicals ACSBG1 Antibodies
    Abcam antibodies for ACSBG1
    Cloud-Clone Corp. Antibodies for ACSBG1 
    Search ThermoFisher Antibodies for ACSBG1
    LSBio Antibodies in human, mouse, rat for ACSBG1 

    Assay Products for ACSBG1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACSBG1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACSBG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACSBG1 
    Cloud-Clone Corp. CLIAs for ACSBG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ACS: Acyl-CoA synthetase family

    2 InterPro protein domains:
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry Q96GR2

    ProtoNet protein and cluster: Q96GR2

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily


    ACSBG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACBG1_HUMAN, Q96GR2
    Function: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via
    beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids;
    however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and
    polyunsaturated fatty acids
    Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA

         Enzyme Number (IUBMB): EC 6.2.1.31 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004467long-chain fatty acid-CoA ligase activity IDA10954726
    GO:0005524ATP binding IEA--
    GO:0031957very long-chain fatty acid-CoA ligase activity IDA10954726
         
    ACSBG1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acsbg1):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    ACSBG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Acsbg1tm1Mld for ACSBG1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACSBG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACSBG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACSBG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACSBG1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSBG1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSBG1:
    hsa-miR-3671 hsa-miR-607 hsa-miR-3622b-3p hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidACSBG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACSBG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSBG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACSBG1
    Sirion Biotech Customized adenovirus for overexpression of ACSBG1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ACSBG1 (see all 7)
    OriGene ORF clones in mouse, rat for ACSBG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACSBG1 (NM_001199377)
    Sino Biological Human cDNA Clone for ACSBG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSBG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSBG1
    Sirion Biotech Customized lentivirus for stable overexpression of ACSBG1 
                         Customized lentivirus expression plasmids for stable overexpression of ACSBG1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACSBG1
    Search LifeMap BioReagents cell lines for ACSBG1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSBG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACSBG1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1fatty acid activation
    fatty acid activation0.55
    fatty acid beta-oxidation VI (peroxisome)0.46
    stearate biosynthesis I (animals)0.55
    fatty acid beta-oxidation I0.40
    2eicosapentaenoate biosynthesis II (metazoa)
    gamma-linolenate biosynthesis II (animals)0.69
    3Metabolism
    Metabolic pathways0.40
    4Fatty Acid Beta Oxidation
    Fatty acid degradation0.32
    5PPAR signaling pathway
    PPAR signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for ACSBG1
        stearate biosynthesis I (animals)
    gamma-linolenate biosynthesis II (animals)
    fatty acid beta-oxidation VI (peroxisome)
    fatty acid beta-oxidation I
    fatty acid activation



    4         Kegg Pathways  (Kegg details for ACSBG1):
        Fatty acid degradation
    Metabolic pathways
    PPAR signaling pathway
    Adipocytokine signaling pathway


    ACSBG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACSBG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/27 Interacting proteins for ACSBG1 (Q96GR22, 3 ENSP000002588734) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8256844 I2D: score=2 
    APPBP2Q926243I2D: score=1 
    YWHABP319463I2D: score=1 
    ACADMENSP000004096124STRING: ENSP00000409612
    ACADVLENSP000003253954STRING: ENSP00000325395
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process IDA10954726
    GO:0001552ovarian follicle atresia IEA--
    GO:0001676long-chain fatty acid metabolic process IDA10954726
    GO:0008152metabolic process ----
    GO:0042552myelination NAS10954726

    ACSBG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACSBG1 (ACBG1)

    10/34 HMDB Compounds for ACSBG1 (see all 34)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    20-COOH-leukotriene E420-COOH-LTE4 (see all 3)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    6,9,12,15,18,21-Tetracosahexaenoic acidall-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)----

    1 DrugBank Compound for ACSBG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about ACSBG1 / ACBG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACSBG1 gene (2 alternative transcripts): 
    NM_001199377.1  NM_015162.4  

    Unigene Cluster for ACSBG1:

    Acyl-CoA synthetase bubblegum family member 1
    Hs.655760  [show with all ESTs]
    Unigene Representative Sequence: NM_015162
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258873(uc010umw.2 uc002bdh.3 uc010umx.2 uc010umy.2)
    ENST00000560124 ENST00000560817 ENST00000560183 ENST00000558301 ENST00000559707
    ENST00000558728 ENST00000557935 ENST00000559114 ENST00000559241 ENST00000558130
    ENST00000558828 ENST00000558793 ENST00000559713 ENST00000541759
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSBG1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSBG1:
    hsa-miR-3671 hsa-miR-607 hsa-miR-3622b-3p hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidACSBG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACSBG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSBG1
    Clone
    Products:
         
    OriGene clones in human, mouse for ACSBG1 (see all 7)
    OriGene ORF clones in mouse, rat for ACSBG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACSBG1 (NM_001199377)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSBG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSBG1
    Sirion Biotech Customized lentivirus for stable overexpression of ACSBG1 
                         Customized lentivirus expression plasmids for stable overexpression of ACSBG1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACSBG1
    OriGene qSTAR qPCR primer pairs in human, mouse for ACSBG1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACSBG1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSBG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSBG1

    Additional mRNA sequence: 

    AF070624.1 AF179481.1 AK054882.1 AK294202.1 AK295269.1 AK299597.1 AK314508.1 BC009289.2 
    BC040252.1 

    9 DOTS entries:

    DT.100824942  DT.95282903  DT.86998295  DT.121032145  DT.95258938  DT.121032179  DT.95258936  DT.97766092 
    DT.101971920 

    24/83 AceView cDNA sequences (see all 83):

    AA779914 BG741938 AI826060 BG697616 CF454811 NM_015162 BC040252 AK054882 
    CD243802 AF179481 AI936780 BG743510 BI756677 AI085608 BF689600 BG742700 
    AB014531 BG698842 CF455960 BE156064 BG740707 BI758180 BG740344 BI829088 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACSBG1 expression in normal human tissues (normalized intensities)      ACSBG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAACTGACT
    ACSBG1 Expression
    About this image


    ACSBG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Globus Pallidus
             Olfactory Bulb   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Endochondral Facial Bones
             skeleton/cranium/viscerocranium   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             skeleton/cranium/viscerocranium   

    See ACSBG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACSBG1

    SOURCE GeneReport for Unigene cluster: Hs.655760

    UniProtKB/Swiss-Prot: ACBG1_HUMAN, Q96GR2
    Tissue specificity: Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in
    all regions of brain except pituitary

        SABiosciences Expression via Pathway-Focused PCR Array including ACSBG1: 
              Fatty Acid Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACSBG1
    OriGene qSTAR qPCR primer pairs in human, mouse for ACSBG1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACSBG1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSBG1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSBG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSBG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ACSBG1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acsbg11 , 5 acyl-CoA synthetase bubblegum family member 11, 5 84.86(n)1
    86.67(a)1
      9 (29.70 cM)5
    941801  NM_053178.21  NP_444408.11 
     546048775 
    chicken
    (Gallus gallus)
    Aves ACSBG11 acyl-CoA synthetase bubblegum family member 1 67.87(n)
    69.57(a)
      415361  XM_413747.2  XP_413747.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACSBG16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343486.1(111006-120976)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000060231 long-chain-fatty-acid--CoA ligase ACSBG1-like 61.72(n)
    61.88(a)
      100006023  XM_001344868.2  XP_001344904.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta bgm6
    CG45006
    --
    39(a)
    37(a)
    many ↔ many
    many ↔ many
    2L(14013747-14019328)
    2L(14027010-14029368)
    worm
    (Caenorhabditis elegans)
    Secernentea acs-186
    acs-156
    (see all 4)
    Protein ACS-15
    (see all 4)
    20(a)
    18(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    IV(10310791-10313670)
    II(933037-936926)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAA26
    Medium chain fatty acyl-CoA synthetase, activates ...
    18(a)
    1 → many
    V(184541-186775)


    ENSEMBL Gene Tree for ACSBG1 (if available)
    TreeFam Gene Tree for ACSBG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACSBG1 gene
    ACSL62  ACSBG22  ACSL12  ACSL52  
    1 SIMAP similar gene for ACSBG1 using alignment to 8 protein entries:     ACBG1_HUMAN (see all proteins):
    ACSBG2

    ACSBG1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACSBG1
    PGOHUM00000262066


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1399 SNPs in ACSBG1 are shown (see all 1399)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38258471,2
    C,F,H--78463486(-) AGTTCC/TAGGTA 2 -- ut31 ese332Minor allele frequency- T:0.06EA NS NA WA 4504
    rs1495345431,2
    --78463599(+) TGAAGC/GTTCTT 2 -- ut310--------
    rs1999919151,2
    C--78463739(+) GGCTCA/GGAACG 2 -- ut310--------
    rs1474702791,2
    C--78463772(+) CTGCAA/GGCATA 2 -- ut310--------
    rs2018747841,2
    --78463798(+) TTTTGC/TTCTTG 4 E syn10--------
    rs2011360521,2
    --78463874(+) GACCTA/TAAAGG 2 -- int10--------
    rs116385471,2
    C,F,A,H--78463890(+) GAGAAG/TAAATG 2 -- int129Minor allele frequency- T:0.22NA EA NS WA CSA 2722
    rs777875931,2
    C--78463910(+) CAGGCT/CCTGAG 2 -- int11Minor allele frequency- C:0.01EA 120
    rs1398524521,2
    --78464015(+) CAAGAC/TAGTGA 2 -- int10--------
    rs1454853761,2
    --78464129(+) AGGTTA/GTAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ACSBG1 (78459810 - 78538030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ACSBG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904430CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ACSBG1
    DNA2.0 Custom Variant and Variant Library Synthesis for ACSBG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614362    OMIM disorders: --

    3 diseases for ACSBG1:    About MalaCards
    adrenoleukodystrophy    tuberculosis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ACSBG1:
    Adrenoleukodystrophy

    ACSBG1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACSBG1
    Human Genome Epidemiology (HuGE) Navigator: ACSBG1 (2 documents)

    Export disorders for ACSBG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACSBG1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ACSBG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents a new family of proteins capable of activating very long-chain fatty acids. (PubMed id 10954726)1, 2, 3 Steinberg S.J....Watkins P.A. (2000)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    3. The acyl-CoA synthetase 'bubblegum' (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.. (PubMed id 12975357)1, 2, 9 Pei Z....Watkins P.A. (2003)
    4. A genome-wide association study of Cloninger's temper ament scales: implications for the evolutionary genetics of personality. (PubMed id 20691247)1, 4 Verweij K.J....Wray N.R. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. (PubMed id 15464426)1, 9 Jia Z....Watkins P.A. (2004)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23205 HGNC: 29567 AceView: BG1 Ensembl:ENSG00000103740 euGenes: HUgn23205
    ECgene: ACSBG1 Kegg: 23205 H-InvDB: ACSBG1

    (According to HUGE)
    About This Section
    HUGE: KIAA0631

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACSBG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACSBG1 gene:
    Search GeneIP for patents involving ACSBG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACSBG1   OriGene RNAi products in human, mouse, rat for ACSBG1  
     OriGene qPCR primer pairs and template standards for ACSBG1   OriGene Protein Over-expression Lysate for ACSBG1  
     OriGene MassSpec something-or-other for ACSBG1   OriGene clones in human, mouse for ACSBG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACSBG1   OriGene Purified Protein for ACSBG1  
     OriGene ORF clones in mouse, rat for ACSBG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACSBG1   OriGene Custom Protein Services for ACSBG1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACSBG1
     QIAGEN SeqTarget long-range PCR primers for resequencing ACSBG1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSBG1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSBG1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSBG1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSBG1
     GenScript Custom Purified and Recombinant Proteins Services for ACSBG1 GenScript cDNA clones with any tag delivered in your preferred vector for ACSBG1
     GenScript Custom Assay Services for ACSBG1 GenScript Custom Superior Antibodies Services for ACSBG1
     GenScript Custom overexpressing Cell Line Services for ACSBG1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACSBG1 promoter
     Search Chromatin IP Primers for ACSBG1
     RT2 qPCR Primer Assay in human, mouse, rat ACSBG1
     GNC Network for ACSBG1
     SABiosciences PCR Arrays including human, mouse, rat ACSBG1
     Search Tocris compounds for ACSBG1 (ACBG1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ACSBG1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ACSBG1 antibodies
     ACSBG1 proteins
     ACSBG1 lysates
     Antibodies for ACSBG1
     See all of Abcam's Antibodies, Kits and Proteins for ACSBG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ACSBG1
     Antibodies for ACSBG1
     ELISAs for ACSBG1
     CLIAs for ACSBG1
     Search LifeMap BioReagents cell lines for ACSBG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSBG1
     SwitchGear 3'UTR luciferase reporter plasmids for ACSBG1
     SwitchGear Promoter luciferase reporter plasmids for ACSBG1
     Search ThermoFisher Antibodies for ACSBG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSBG1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ACSBG1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACSBG1
    Customized:
     lentivirus for stable overexpression of ACSBG1
     lentivirus expression plasmids for stable overexpression of ACSBG1
     adenovirus for overexpression of ACSBG1
     LSBio Antibodies in human, mouse, rat for ACSBG1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACSBG1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4