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Aliases for ACRV1 Gene

Aliases for ACRV1 Gene

  • Acrosomal Vesicle Protein 1 2 3 4
  • Sperm Protein 10 2 3
  • Acrosomal Protein SP-10 3
  • D11S4365 3
  • SPACA2 3
  • SP-10 3

External Ids for ACRV1 Gene

Previous GeneCards Identifiers for ACRV1 Gene

  • GC11M127543
  • GC11M127055
  • GC11M125576
  • GC11M125079
  • GC11M125047
  • GC11M121483

Summaries for ACRV1 Gene

Entrez Gene Summary for ACRV1 Gene

  • This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

GeneCards Summary for ACRV1 Gene

ACRV1 (Acrosomal Vesicle Protein 1) is a Protein Coding gene. Diseases associated with ACRV1 include hordeolum.

Gene Wiki entry for ACRV1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACRV1 Gene

Genomics for ACRV1 Gene

Regulatory Elements for ACRV1 Gene

Genomic Location for ACRV1 Gene

125,671,522 bp from pter
125,681,123 bp from pter
9,602 bases
Minus strand

Genomic View for ACRV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACRV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACRV1 Gene

Proteins for ACRV1 Gene

neXtProt entry for ACRV1 Gene

Proteomics data for ACRV1 Gene at MOPED

Post-translational modifications for ACRV1 Gene

Other Protein References for ACRV1 Gene

No data available for DME Specific Peptides for ACRV1 Gene

Domains for ACRV1 Gene

Protein Domains for ACRV1 Gene


Suggested Antigen Peptide Sequences for ACRV1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ACRV1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ACRV1 Gene

Function for ACRV1 Gene

Molecular function for ACRV1 Gene

GENATLAS Biochemistry: acrosomal vesicle protein 1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACRV1 Gene

Localization for ACRV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACRV1 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Nascent acrosomal vesicle of Golgi phase spermatids.

Subcellular locations from

Jensen Localization Image for ACRV1 Gene COMPARTMENTS Subcellular localization image for ACRV1 gene
Compartment Confidence
extracellular 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ACRV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
genes like me logo Genes that share ontologies with ACRV1: view

Pathways for ACRV1 Gene

SuperPathways for ACRV1 Gene

No Data Available

Interacting Proteins for ACRV1 Gene

Gene Ontology (GO) - Biological Process for ACRV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development TAS 1693291
genes like me logo Genes that share ontologies with ACRV1: view

No data available for Pathways by source for ACRV1 Gene

Transcripts for ACRV1 Gene

mRNA/cDNA for ACRV1 Gene

(11) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACRV1 Gene

Acrosomal vesicle protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACRV1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP4: -

Relevant External Links for ACRV1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACRV1 Gene

mRNA expression in normal human tissues for ACRV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACRV1 Gene

This gene is overexpressed in Testis (42.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ACRV1 Gene

SOURCE GeneReport for Unigene cluster for ACRV1 Gene Hs.169222

mRNA Expression by UniProt/SwissProt for ACRV1 Gene

Tissue specificity: Testis
genes like me logo Genes that share expressions with ACRV1: view

Orthologs for ACRV1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ACRV1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACRV1 35
  • 97.62 (n)
  • 95.71 (a)
ACRV1 36
  • 97 (a)
(Bos Taurus)
Mammalia ACRV1 35
  • 75.92 (n)
  • 67.3 (a)
ACRV1 36
  • 62 (a)
(Canis familiaris)
Mammalia ACRV1 35
  • 82.26 (n)
  • 76.43 (a)
ACRV1 36
  • 61 (a)
(Mus musculus)
Mammalia Acrv1 35
  • 72.4 (n)
  • 64.34 (a)
Acrv1 16
Acrv1 36
  • 61 (a)
(Rattus norvegicus)
Mammalia Acrv1 35
  • 73.41 (n)
  • 65.18 (a)
Species with no ortholog for ACRV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACRV1 Gene

Gene Tree for ACRV1 (if available)
Gene Tree for ACRV1 (if available)

Paralogs for ACRV1 Gene

No data available for Paralogs for ACRV1 Gene

Variants for ACRV1 Gene

Sequence variations from dbSNP and Humsavar for ACRV1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs494296 -- 125,678,914(-) CCCCA(A/C)CCCAC intron-variant
rs506652 -- 125,678,698(-) ACCCA(C/T)AGAGG intron-variant
rs524491 -- 125,677,900(-) GGCTC(C/G)GGTGA reference, synonymous-codon
rs535132 -- 125,682,688(-) AGGCT(C/G)AGAAA upstream-variant-2KB
rs543225 -- 125,680,985(-) AGCAG(G/T)GGGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ACRV1 Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV Gain+Loss 17666407
nsv39485 CNV Loss 16902084

Relevant External Links for ACRV1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACRV1 Gene

Disorders for ACRV1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ACRV1 Gene including...

Search for ACRV1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ACRV1 Gene

Relevant External Links for ACRV1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ACRV1: view

No data available for UniProtKB/Swiss-Prot for ACRV1 Gene

Publications for ACRV1 Gene

  1. Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10. (PMID: 1693291) Wright R.M. … Herr J.C. (Biol. Reprod. 1990) 2 3 4 23
  2. Characterization of alternatively spliced human SP-10 mRNAs. (PMID: 7619499) Freemerman A.J. … Herr J.C. (Mol. Reprod. Dev. 1995) 3 4 23
  3. Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23-->q24 of chromosome 11 by nonisotopic in situ hybridization. (PMID: 8288254) Golden W.L. … Herr J.C. (Genomics 1993) 2 3 23
  4. Cloning and characterization of the gene coding for the human acrosomal protein SP-10. (PMID: 8373955) Wright R.M. … Herr J.C. (Biol. Reprod. 1993) 3 4 23
  5. Purification and microsequencing of the intra-acrosomal protein SP- 10. Evidence that SP-10 heterogeneity results from endoproteolytic processes. (PMID: 1637938) Herr J.C. … Flickinger C.J. (Biol. Reprod. 1992) 3 4 23

Products for ACRV1 Gene

Sources for ACRV1 Gene

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