Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACRV1 Gene

Aliases for ACRV1 Gene

  • Acrosomal Vesicle Protein 1 2 3 4 5
  • Sperm Protein 10 2 3
  • Acrosomal Protein SP-10 3
  • D11S4365 3
  • SPACA2 3
  • SP-10 3

External Ids for ACRV1 Gene

Previous GeneCards Identifiers for ACRV1 Gene

  • GC11M127543
  • GC11M127055
  • GC11M125576
  • GC11M125079
  • GC11M125047
  • GC11M121483

Summaries for ACRV1 Gene

Entrez Gene Summary for ACRV1 Gene

  • This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

GeneCards Summary for ACRV1 Gene

ACRV1 (Acrosomal Vesicle Protein 1) is a Protein Coding gene. Diseases associated with ACRV1 include Hordeolum and Spastic Paraplegia 24, Autosomal Recessive.

Gene Wiki entry for ACRV1 Gene

Additional gene information for ACRV1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACRV1 Gene

Genomics for ACRV1 Gene

Regulatory Elements for ACRV1 Gene

Enhancers for ACRV1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H125624 1.2 ENCODE 4.9 +55.1 55053 3 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 HP11014 MSANTD2 FEZ1 CCDC15 CHEK1 TMEM218 ACRV1 PUS3 RNU2-35P
GH11H125690 0.3 FANTOM5 0.4 -9.9 -9900 0 CHEK1 PIR40176 ACRV1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACRV1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACRV1 Gene

Chromosome:
11
Start:
125,671,522 bp from pter
End:
125,681,123 bp from pter
Size:
9,602 bases
Orientation:
Minus strand

Genomic View for ACRV1 Gene

Genes around ACRV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACRV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACRV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACRV1 Gene

Proteins for ACRV1 Gene

neXtProt entry for ACRV1 Gene

Post-translational modifications for ACRV1 Gene

Other Protein References for ACRV1 Gene

Antibody Products

No data available for DME Specific Peptides for ACRV1 Gene

Domains & Families for ACRV1 Gene

Gene Families for ACRV1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ACRV1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACRV1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ACRV1: view

No data available for UniProtKB/Swiss-Prot for ACRV1 Gene

Function for ACRV1 Gene

Molecular function for ACRV1 Gene

GENATLAS Biochemistry:
acrosomal vesicle protein 1
genes like me logo Genes that share phenotypes with ACRV1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACRV1 Gene

Localization for ACRV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACRV1 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Nascent acrosomal vesicle of Golgi phase spermatids.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACRV1 gene
Compartment Confidence
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for ACRV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ACRV1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACRV1 Gene

Pathways & Interactions for ACRV1 Gene

SuperPathways for ACRV1 Gene

No Data Available

Interacting Proteins for ACRV1 Gene

Gene Ontology (GO) - Biological Process for ACRV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 1693291
genes like me logo Genes that share ontologies with ACRV1: view

No data available for Pathways by source and SIGNOR curated interactions for ACRV1 Gene

Drugs & Compounds for ACRV1 Gene

No Compound Related Data Available

Transcripts for ACRV1 Gene

mRNA/cDNA for ACRV1 Gene

(11) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACRV1 Gene

Acrosomal vesicle protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACRV1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for ACRV1 Gene

GeneLoc Exon Structure for
ACRV1
ECgene alternative splicing isoforms for
ACRV1

Expression for ACRV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACRV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACRV1 Gene

This gene is overexpressed in Testis (x42.1).

Protein differential expression in normal tissues from HIPED for ACRV1 Gene

This gene is overexpressed in Testis (60.9) and Ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACRV1 Gene



Protein tissue co-expression partners for ACRV1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACRV1 Gene:

ACRV1

SOURCE GeneReport for Unigene cluster for ACRV1 Gene:

Hs.169222

mRNA Expression by UniProt/SwissProt for ACRV1 Gene:

P26436-ASPX_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with ACRV1: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACRV1 Gene

Orthologs for ACRV1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ACRV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACRV1 33 34
  • 97.62 (n)
dog
(Canis familiaris)
Mammalia ACRV1 33 34
  • 82.26 (n)
cow
(Bos Taurus)
Mammalia ACRV1 33 34
  • 75.92 (n)
rat
(Rattus norvegicus)
Mammalia Acrv1 33
  • 73.41 (n)
mouse
(Mus musculus)
Mammalia Acrv1 33 16 34
  • 72.4 (n)
Species where no ortholog for ACRV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACRV1 Gene

ENSEMBL:
Gene Tree for ACRV1 (if available)
TreeFam:
Gene Tree for ACRV1 (if available)

Paralogs for ACRV1 Gene

No data available for Paralogs for ACRV1 Gene

Variants for ACRV1 Gene

Sequence variations from dbSNP and Humsavar for ACRV1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs193921098 Uncertain significance 125,676,409(-) GGGAA(C/T)CTGCA downstream-variant-500B, reference, missense
rs1000218137 -- 125,672,747(+) TGAGC(A/C)GAAAG intron-variant
rs1000387485 -- 125,677,823(+) GTGCA(C/T)CTGAA intron-variant, reference, missense
rs1000992894 -- 125,676,279(+) GGGCC(C/T)CTGTC intron-variant, downstream-variant-500B
rs1001258052 -- 125,676,527(+) GATGT(A/G)TAGCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ACRV1 Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV gain+loss 17666407
nsv39485 CNV deletion 16902084

Variation tolerance for ACRV1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACRV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACRV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACRV1 Gene

Disorders for ACRV1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ACRV1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hordeolum
  • boil of eyelid
spastic paraplegia 24, autosomal recessive
  • hereditary spastic paraplegia 24
skin sarcoma
  • cutaneous sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search ACRV1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACRV1

Genetic Association Database (GAD)
ACRV1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACRV1
genes like me logo Genes that share disorders with ACRV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACRV1 Gene

Publications for ACRV1 Gene

  1. Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10. (PMID: 1693291) Wright RM … Herr JC (Biology of reproduction 1990) 2 3 4 22 60
  2. Characterization of alternatively spliced human SP-10 mRNAs. (PMID: 7619499) Freemerman AJ … Herr JC (Molecular reproduction and development 1995) 3 4 22 60
  3. Cloning and characterization of the gene coding for the human acrosomal protein SP-10. (PMID: 8373955) Wright RM … Herr JC (Biology of reproduction 1993) 3 4 22 60
  4. Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23-->q24 of chromosome 11 by nonisotopic in situ hybridization. (PMID: 8288254) Golden WL … Herr JC (Genomics 1993) 2 3 22 60
  5. Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes. (PMID: 1637938) Herr JC … Flickinger CJ (Biology of reproduction 1992) 3 4 22 60

Products for ACRV1 Gene

Sources for ACRV1 Gene

Content
Loading form....