ACRC Gene
protein-coding GIFtS: 41
GCID: GC0XP070797
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|
acidic repeat containing
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Aliases
for ACRC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Acidic Repeat Containing1 2 | | NAAR12 | | Acidic Repeat-Containing Protein2 | | Putative Nuclear Protein2 |
Export aliases for ACRC gene to outside databasesPrevious GC identifers: GC0XP066974 GC0XP068275 GC0XP069031 GC0XP069665 GC0XP070581 GC0XP070714 GC0XP064613 |
Summaries
for ACRC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for ACRC (Acidic repeat-containing protein)
|
Genomic Views
for ACRC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ACRC gene promoter:
HOXA9 HOXA9B AML1a AREB6 PPAR-gamma1 POU2F1 POU2F1a Meis-1a PPAR-gamma2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACRC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACRC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1ACRC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP070797: view genomic region
(about GC identifiers)
Start:
|
70,797,874 bp from pter |
End:
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70,833,433 bp from pter |
Size:
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35,560 bases |
Orientation:
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plus strand |
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Proteins
for ACRC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACRC_HUMAN, Q96QF7 (See
protein sequence)Recommended Name: Acidic repeat-containing protein Size: 691 amino acids; 76112 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B9EG62Explore the universe of human proteins at neXtProt for ACRC: NX_Q96QF7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96QF7
ACRC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443189.1
ENSEMBL proteins: ENSP00000362800 ENSP00000362799
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ACRC for ontologies About GeneDecksing
ACRC Antibody Products:
Assay Products for ACRC: |
Protein
Domains /
Families
for ACRC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACRC for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96QF7ProtoNet protein and cluster: Q96QF7 UniProtKB/Swiss-Prot: ACRC_HUMAN, Q96QF7Similarity: Belongs to the serine-aspartate repeat-containing protein (SDr) familySimilarity: Contains 1 SprT-like domain |
Function
for ACRC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACRC
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACRC (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ACRC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACRC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACRC |
|
Pathways & Interactions
for ACRC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACRC
|
Drugs & Compounds
for ACRC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACRC
Search CenterWatch for drugs/clinical trials and news about ACRC
|
Transcripts
for ACRC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACRC gene: NM_052957.4 Unigene Cluster for ACRC: Acidic repeat containing Hs.135167 [show with all ESTs]Unigene Representative Sequence: AK1276073 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373696(uc004eae.2) ENST00000373695 ENST00000471950
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACRC
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACRC (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ACRC (NM_052957) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACRC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACRC |
Additional cDNA sequence: AJ311392.1 AK097433.1 AK127607.1 BC136259.1 4 DOTS entries: DT.40207812 DT.91750088 DT.92057405 DT.40193667 19 AceView cDNA sequences: AK097433 AI802181 BX097632 AK127607 BM723012 BM677469 BQ719419 AJ311392 BF197762 NM_052957 AA385823 AI091533 CD641988 CD642018 BX490968 AV712376 AI276640 CD520254 AV760822
GeneLoc Exon Structure
|
Expression
for ACRC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACRC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ACRC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACRC
SOURCE GeneReport for Unigene cluster: Hs.135167
UniProtKB/Swiss-Prot: ACRC_HUMAN, Q96QF7Tissue specificity: Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain
SABiosciences Custom PCR Arrays for ACRC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACRC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ACRC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACRC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACRC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACRC |
Orthologs
for ACRC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ACRC gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ACRC6 |
Uncharacterized protein |
27(a) |
1 ↔ 1 |
4(2174236-2181530) |
lizard
(Anolis carolinensis) |
Reptilia |
ACRC6 |
-- |
50(a) |
1 ↔ 1 |
GL343855.1(110169-114390) |
zebrafish
(Danio rerio) |
Actinopterygii |
acrc6 |
acidic repeat containing |
22(a) |
1 ↔ 1 |
14(18567252-18587004) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG148146 |
-- |
10(a) |
1 ↔ 1 |
X(1756042-1759868) |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK328.41 |
Protein ZK328.4 |
41.27(n)
28.61(a) |
|
175850 NM_065906.3 NP_498307.1 |
Species with no ortholog for ACRC
ENSEMBL Gene Tree for ACRC (if available)
TreeFam Gene Tree for ACRC (if available) |
Paralogs
for ACRC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACRC gene
ACRC for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ACRC
PGOHUM00000239332
|
Genomic Variants
for ACRC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACRC (70797874 - 70833433 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for ACRC
5 CNVs: 7797 83583 96745 96746 83584
4 Indels: 83582 83585 96747 74004 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACRC |
|
Disorders
/ Diseases
for ACRC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ACRC for disorders About GeneDecksing
OMIM gene information: 300369
OMIM disorders: --
2  diseases for ACRC: About MalaCardsappendix adenocarcinoma adenocarcinoma
1 disease from the University of Copenhagen DISEASES database for ACRC:Appendix adenocarcinoma Export disorders for ACRC gene to outside databases
|
Publications
for ACRC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACRC gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACRC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1. (PubMed id 11714101)1, 2 Nolte D.... Muller U. (2001)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ACRC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ACRC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACRC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACRC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ACRC | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ACRC gene:
Search GeneIP for patents involving ACRC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACRC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ACRC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACRC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACRC | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ACRC | | OriGene 3'-UTR Clone for ACRC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACRC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACRC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  |  |  |  | | | | |
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 | | | ACRC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACRC |
|  |  |  | | | | Search ThermoFisher Antibodies for ACRC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACRC |
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