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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACRC Gene

protein-coding   GIFtS: 43
GCID: GC0XP070797

Acidic Repeat Containing

Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acidic Repeat Containing1 2
NAAR12
Acidic Repeat-Containing Protein2
Putative Nuclear Protein2

External Ids:    HGNC: 158051   Entrez Gene: 939532   Ensembl: ENSG000001471747   OMIM: 3003695   UniProtKB: Q96QF73   

Export aliases for ACRC gene to outside databases

Previous GC identifers: GC0XP066974 GC0XP068275 GC0XP069031 GC0XP069665 GC0XP070581 GC0XP070714 GC0XP064613


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ACRC Gene: 
ACRC (acidic repeat containing) is a protein-coding gene. Diseases associated with ACRC include appendix adenocarcinoma, and adenocarcinoma.

Gene Wiki entry for ACRC (Acidic repeat-containing protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACRC gene promoter:
         HOXA9   HOXA9B   AML1a   AREB6   PPAR-gamma1   POU2F1   POU2F1a   Meis-1a   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACRC promoter sequence
   Search SABiosciences Chromatin IP Primers for ACRC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACRC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

ACRC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACRC gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP070797:  view genomic region     (about GC identifiers)

Start:
70,797,874 bp from pter      End:
70,833,433 bp from pter
Size:
35,560 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACRC_HUMAN, Q96QF7 (See protein sequence)
Recommended Name: Acidic repeat-containing protein  
Size: 691 amino acids; 76112 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B9EG62

Explore the universe of human proteins at neXtProt for ACRC: NX_Q96QF7

Explore proteomics data for ACRC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96QF7

  • ACRC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACRC Protein Expression
    REFSEQ proteins: NP_443189.1  
    ENSEMBL proteins: 
     ENSP00000362800   ENSP00000362799  

    Human Recombinant Protein Products for ACRC: 
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    Cloud-Clone Corp. Proteins for ACRC 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ACRC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006640 SprT-like_domain

    Graphical View of Domain Structure for InterPro Entry Q96QF7

    ProtoNet protein and cluster: Q96QF7

    UniProtKB/Swiss-Prot: ACRC_HUMAN, Q96QF7
    Similarity: Belongs to the serine-aspartate repeat-containing protein (SDr) family
    Similarity: Contains 1 SprT-like domain


    ACRC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACRC 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACRC

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACRC

    Search CenterWatch for drugs/clinical trials and news about ACRC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACRC gene: 
    NM_052957.4  

    Unigene Cluster for ACRC:

    Acidic repeat containing
    Hs.135167  [show with all ESTs]
    Unigene Representative Sequence: AK127607
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373696(uc004eae.2) ENST00000373695 ENST00000471950

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    Additional mRNA sequence: 

    AJ311392.1 AK097433.1 AK127607.1 BC136259.1 

    4 DOTS entries:

    DT.40207812  DT.91750088  DT.92057405  DT.40193667 

    19 AceView cDNA sequences:

    NM_052957 AJ311392 BM677469 BM723012 BF197762 AI802181 AK097433 BX097632 
    AK127607 BQ719419 AA385823 CD641988 AI091533 CD642018 BX490968 AV712376 
    AI276640 CD520254 AV760822 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACRC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ACRC Expression
    About this image


    See ACRC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACRC

    SOURCE GeneReport for Unigene cluster: Hs.135167

    UniProtKB/Swiss-Prot: ACRC_HUMAN, Q96QF7
    Tissue specificity: Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACRC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACRC gene from 6/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ACRC6
    acidic repeat containing
    46(a)
    1 ↔ 1
    X(55859684-55881378)
    chicken
    (Gallus gallus)
    Aves ACRC6
    Uncharacterized protein
    25(a)
    1 ↔ 1
    4(2169808-2177051)
    lizard
    (Anolis carolinensis)
    Reptilia ACRC6
    Uncharacterized protein
    35(a)
    1 ↔ 1
    GL343855.1(109695-121547)
    zebrafish
    (Danio rerio)
    Actinopterygii acrc6
    acidic repeat containing
    22(a)
    1 ↔ 1
    14(18567252-18587004)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG148146
    --
    8(a)
    1 ↔ 1
    X(1756042-1759868)
    worm
    (Caenorhabditis elegans)
    Secernentea ZK328.41 Protein ZK328.4 41.27(n)
    28.61(a)
      175850  NM_065906.3  NP_498307.1 


    ENSEMBL Gene Tree for ACRC (if available)
    TreeFam Gene Tree for ACRC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACRC gene

    ACRC for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACRC
    PGOHUM00000239332


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/439 SNPs in ACRC are shown (see all 439)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908116561,2
    --70796351(+) CCATTA/CTTTTC 1 -- us2k10--------
    rs1407821941,2
    --70796728(+) AGTAAA/GTGTGT 1 -- us2k10--------
    rs1820517271,2
    C--70796814(+) AATTAC/TAGCTA 1 -- us2k10--------
    rs1862136851,2
    --70796892(+) GTAGAA/GGTTAA 1 -- us2k10--------
    rs2017620181,2
    --70797395(+) TGCTA-/ACAGTTG 1 -- us2k10--------
    rs1383914641,2
    --70797478(+) AAACGC/TAGGGA 1 -- us2k10--------
    rs1896251681,2
    --70797729(+) TAGGGG/TTCTAG 1 -- us2k10--------
    rs120121401,2
    H--70797866(+) cccccC/Ggcgcc 1 -- us2k1 trp34Minor allele frequency- G:0.00NS EA 418
    rs1812649531,2
    --70797931(+) ACAAGC/GCTCGC 1 -- ut510--------
    rs1493167401,2
    --70798004(+) AGAAAC/GTTGTT 1 -- ut510--------

    HapMap Linkage Disequilibrium report for ACRC (70797874 - 70833433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ACRC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740214CNV Deletion23290073
    nsv6954CNV Insertion18451855
    esv33082CNV Loss17666407
    esv27144CNV Gain19812545
    esv1584074OTHER Inversion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300369    OMIM disorders: --

    2 diseases for ACRC:    About MalaCards
    appendix adenocarcinoma    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for ACRC:
    Appendix adenocarcinoma

    ACRC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for ACRC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACRC gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ACRC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1. (PubMed id 11714101)1, 2 Nolte D.... Muller U. (2001)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93953 HGNC: 15805 AceView: ACRC Ensembl:ENSG00000147174 euGenes: HUgn93953
    ECgene: ACRC H-InvDB: ACRC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACRC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACRC gene:
    Search GeneIP for patents involving ACRC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Proteins for ACRC
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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