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Aliases for ACRBP Gene

Aliases for ACRBP Gene

  • Acrosin Binding Protein 2 3
  • Cancer/Testis Antigen 23 2 3 4
  • Proacrosin Binding Protein Sp32 2 3
  • Cancer/Testis Antigen OY-TES-1 3 4
  • CT23 3 4
  • Proacrosin-Binding Protein Sp32 4
  • Acrosin-Binding Protein 3
  • OY-TES-1 3
  • SP32 3

External Ids for ACRBP Gene

Previous GeneCards Identifiers for ACRBP Gene

  • GC12M006688
  • GC12M006813
  • GC12M006626
  • GC12M006617
  • GC12M006748

Summaries for ACRBP Gene

Entrez Gene Summary for ACRBP Gene

  • The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACRBP Gene

ACRBP (Acrosin Binding Protein) is a Protein Coding gene. Diseases associated with ACRBP include arteriolosclerosis.

UniProtKB/Swiss-Prot for ACRBP Gene

  • May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACRBP Gene

Genomics for ACRBP Gene

Regulatory Elements for ACRBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACRBP Gene

Start:
6,638,075 bp from pter
End:
6,647,460 bp from pter
Size:
9,386 bases
Orientation:
Minus strand

Genomic View for ACRBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACRBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACRBP Gene

Proteins for ACRBP Gene

  • Protein details for ACRBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEB7-ACRBP_HUMAN
    Recommended name:
    Acrosin-binding protein
    Protein Accession:
    Q8NEB7
    Secondary Accessions:
    • Q9BY87

    Protein attributes for ACRBP Gene

    Size:
    543 amino acids
    Molecular mass:
    61359 Da
    Quaternary structure:
    • Binds proacrosin.

neXtProt entry for ACRBP Gene

Proteomics data for ACRBP Gene at MOPED

Post-translational modifications for ACRBP Gene

Other Protein References for ACRBP Gene

No data available for DME Specific Peptides for ACRBP Gene

Domains for ACRBP Gene

Protein Domains for ACRBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACRBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ACRBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ACRBP Gene

Function for ACRBP Gene

Molecular function for ACRBP Gene

UniProtKB/Swiss-Prot Function: May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.

Gene Ontology (GO) - Molecular Function for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ACRBP: view

Phenotypes for ACRBP Gene

MGI mutant phenotypes for ACRBP:
inferred from 1 alleles
GenomeRNAi human phenotypes for ACRBP:
genes like me logo Genes that share phenotypes with ACRBP: view

Animal Models for ACRBP Gene

MGI Knock Outs for ACRBP:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACRBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ACRBP Gene

Localization for ACRBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACRBP Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Colocalizes with proacrosin in the acrosome of sperm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACRBP Gene COMPARTMENTS Subcellular localization image for ACRBP gene
Compartment Confidence
extracellular 3
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 21630459
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with ACRBP: view

Pathways for ACRBP Gene

SuperPathways for ACRBP Gene

No Data Available

Interacting Proteins for ACRBP Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000229243%0d%0a9606.ENSP00000405965%0d%0a9606.ENSP00000414359%0d%0a9606.ENSP00000457299%0d%0a
Selected Interacting proteins: ENSP00000229243 for ACRBP Gene via STRING

Gene Ontology (GO) - Biological Process for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ACRBP: view

No data available for Pathways by source for ACRBP Gene

Transcripts for ACRBP Gene

Unigene Clusters for ACRBP Gene

Acrosin binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACRBP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACRBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - - - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for ACRBP Gene

GeneLoc Exon Structure for
ACRBP
ECgene alternative splicing isoforms for
ACRBP

Expression for ACRBP Gene

mRNA expression in normal human tissues for ACRBP Gene

mRNA differential expression in normal tissues according to GTEx for ACRBP Gene

This gene is overexpressed in Testis (38.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACRBP Gene

SOURCE GeneReport for Unigene cluster for ACRBP Gene Hs.123239

mRNA Expression by UniProt/SwissProt for ACRBP Gene

Q8NEB7-ACRBP_HUMAN
Tissue specificity: Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.
genes like me logo Genes that share expressions with ACRBP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ACRBP Gene

Orthologs for ACRBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACRBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACRBP 35
  • 99.26 (n)
  • 99.08 (a)
ACRBP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACRBP 35
  • 81.21 (n)
  • 79.85 (a)
ACRBP 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACRBP 35
  • 85.11 (n)
  • 81.12 (a)
ACRBP 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acrbp 35
  • 80.95 (n)
  • 77.38 (a)
Acrbp 16
Acrbp 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACRBP 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACRBP 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acrbp 35
  • 78.98 (n)
  • 76.66 (a)
chicken
(Gallus gallus)
Aves ACRBP 35
  • 56.93 (n)
  • 45.53 (a)
ACRBP 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACRBP 36
  • 35 (a)
OneToOne
Species with no ortholog for ACRBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACRBP Gene

ENSEMBL:
Gene Tree for ACRBP (if available)
TreeFam:
Gene Tree for ACRBP (if available)

Paralogs for ACRBP Gene

No data available for Paralogs for ACRBP Gene

Variants for ACRBP Gene

Sequence variations from dbSNP and Humsavar for ACRBP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1882553 -- 6,638,412(+) ACACA(C/G)AGATT intron-variant
rs2178694 -- 6,642,704(+) TTGTC(C/T)TCCCA intron-variant
rs2365087 -- 6,639,927(+) AGGAG(A/G)TTCAG intron-variant
rs3054294 -- 6,645,678(+) ttttt(-/TT)gagac intron-variant
rs3741923 - 6,643,610(+) GCAGG(C/T)ATTCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ACRBP Gene

Variant ID Type Subtype PubMed ID
nsv509452 CNV Insertion 20534489
nsv832322 CNV Loss 17160897
nsv898635 CNV Loss 21882294

Relevant External Links for ACRBP Gene

HapMap Linkage Disequilibrium report
ACRBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACRBP Gene

Disorders for ACRBP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ACRBP Gene including...

Search for ACRBP Gene in MalaCards »

(1) University of Copenhagen DISEASES for ACRBP Gene

genes like me logo Genes that share disorders with ACRBP: view

No data available for UniProtKB/Swiss-Prot for ACRBP Gene

Publications for ACRBP Gene

  1. Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. (PMID: 11248070) Ono T. … Nakayama E. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells. (PMID: 16301813) Okumura H. … Nakayama E. (Microbiol. Immunol. 2005) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation. (PMID: 20876808) Whitehurst A.W. … White M.A. (Cancer Res. 2010) 3
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for ACRBP Gene

Sources for ACRBP Gene

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