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Aliases for ACRBP Gene

Aliases for ACRBP Gene

  • Acrosin Binding Protein 2 3 5
  • Cancer/Testis Antigen 23 2 3 4
  • Proacrosin Binding Protein Sp32 2 3
  • Cancer/Testis Antigen OY-TES-1 3 4
  • CT23 3 4
  • Testicular Tissue Protein Li 10 3
  • Proacrosin-Binding Protein Sp32 4
  • Acrosin-Binding Protein 3
  • OY-TES-1 3
  • SP32 3

External Ids for ACRBP Gene

Previous GeneCards Identifiers for ACRBP Gene

  • GC12M006688
  • GC12M006813
  • GC12M006626
  • GC12M006617
  • GC12M006748

Summaries for ACRBP Gene

Entrez Gene Summary for ACRBP Gene

  • The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACRBP Gene

ACRBP (Acrosin Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ACRBP Gene

  • May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.

Additional gene information for ACRBP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACRBP Gene

Genomics for ACRBP Gene

Regulatory Elements for ACRBP Gene

Enhancers for ACRBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006602 1.7 FANTOM5 ENCODE dbSUPER 16.7 +41.7 41733 7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF384 ENSG00000219410 ENSG00000247853 CHD4 NOP2 ING4 NCAPD2 SPSB2 EMG1 SCARNA12
GH12H006344 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +300.9 300851 3 PKNOX1 ATF1 ARNT SIN3A BRCA1 TCF12 GATA2 ATF7 FOS DEK CHD4 ENSG00000219410 ZNF384 ENSG00000247853 PHB2 LTBR SCNN1A VAMP1 C1RL-AS1 ENSG00000256967
GH12H006546 1.7 FANTOM5 ENCODE dbSUPER 10.4 +95.5 95545 10 HDGF PKNOX1 ARID4B GLI4 YY1 GLIS2 ZNF143 FOS KLF7 ZNF548 CHD4 ENSG00000247853 ENSG00000219410 TAPBPL VAMP1 ZNF384 SCARNA11 SCARNA10 NCAPD2 ATN1
GH12H006777 1.6 Ensembl ENCODE dbSUPER 10.7 -131.5 -131520 2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GPR162 P3H3 EMG1 ZNF384 ENSG00000219410 ING4 PIANP ACRBP LPAR5 ENSG00000255966
GH12H006331 1.8 FANTOM5 ENCODE dbSUPER 9.5 +309.3 309322 12 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ENSG00000219410 ZNF384 ENSG00000247853 NCAPD2 CHD4 ING4 SPSB2 VAMP1 TAPBPL SCNN1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACRBP on UCSC Golden Path with GeneCards custom track

Promoters for ACRBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048333 160 601 POLR2A MAX MNT

Genomic Location for ACRBP Gene

Chromosome:
12
Start:
6,638,075 bp from pter
End:
6,647,460 bp from pter
Size:
9,386 bases
Orientation:
Minus strand

Genomic View for ACRBP Gene

Genes around ACRBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACRBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACRBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACRBP Gene

Proteins for ACRBP Gene

  • Protein details for ACRBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEB7-ACRBP_HUMAN
    Recommended name:
    Acrosin-binding protein
    Protein Accession:
    Q8NEB7
    Secondary Accessions:
    • Q9BY87

    Protein attributes for ACRBP Gene

    Size:
    543 amino acids
    Molecular mass:
    61359 Da
    Quaternary structure:
    • Binds proacrosin.

neXtProt entry for ACRBP Gene

Post-translational modifications for ACRBP Gene

Other Protein References for ACRBP Gene

No data available for DME Specific Peptides for ACRBP Gene

Domains & Families for ACRBP Gene

Gene Families for ACRBP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ACRBP Gene

Suggested Antigen Peptide Sequences for ACRBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ACRBP: view

No data available for UniProtKB/Swiss-Prot for ACRBP Gene

Function for ACRBP Gene

Molecular function for ACRBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.

Phenotypes From GWAS Catalog for ACRBP Gene

Gene Ontology (GO) - Molecular Function for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ACRBP: view
genes like me logo Genes that share phenotypes with ACRBP: view

Animal Models for ACRBP Gene

MGI Knock Outs for ACRBP:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACRBP

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ACRBP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ACRBP Gene

Localization for ACRBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACRBP Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACRBP gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0002080 acrosomal membrane ISS --
GO:0005576 extracellular region ISS --
GO:0005634 nucleus IDA 21630459
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ACRBP: view

Pathways & Interactions for ACRBP Gene

SuperPathways for ACRBP Gene

No Data Available

Interacting Proteins for ACRBP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000229243%0d%0a9606.ENSP00000368237%0d%0a
Selected Interacting proteins: Q8NEB7-ACRBP_HUMAN ENSP00000229243 for ACRBP Gene via IID STRING

Gene Ontology (GO) - Biological Process for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0048240 sperm capacitation IBA --
genes like me logo Genes that share ontologies with ACRBP: view

No data available for Pathways by source and SIGNOR curated interactions for ACRBP Gene

Drugs & Compounds for ACRBP Gene

No Compound Related Data Available

Transcripts for ACRBP Gene

Unigene Clusters for ACRBP Gene

Acrosin binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ACRBP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ACRBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - - - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for ACRBP Gene

GeneLoc Exon Structure for
ACRBP
ECgene alternative splicing isoforms for
ACRBP

Expression for ACRBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACRBP Gene

mRNA differential expression in normal tissues according to GTEx for ACRBP Gene

This gene is overexpressed in Testis (x38.4).

Protein differential expression in normal tissues from HIPED for ACRBP Gene

This gene is overexpressed in Testis (50.4) and Ovary (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACRBP Gene



Protein tissue co-expression partners for ACRBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACRBP Gene:

ACRBP

SOURCE GeneReport for Unigene cluster for ACRBP Gene:

Hs.123239

mRNA Expression by UniProt/SwissProt for ACRBP Gene:

Q8NEB7-ACRBP_HUMAN
Tissue specificity: Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.

Evidence on tissue expression from TISSUES for ACRBP Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with ACRBP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACRBP Gene

Orthologs for ACRBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACRBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACRBP 33 34
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia ACRBP 33 34
  • 85.11 (n)
cow
(Bos Taurus)
Mammalia ACRBP 33 34
  • 81.21 (n)
mouse
(Mus musculus)
Mammalia Acrbp 33 16 34
  • 80.95 (n)
rat
(Rattus norvegicus)
Mammalia Acrbp 33
  • 78.98 (n)
oppossum
(Monodelphis domestica)
Mammalia ACRBP 34
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACRBP 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACRBP 33 34
  • 56.93 (n)
lizard
(Anolis carolinensis)
Reptilia ACRBP 34
  • 35 (a)
OneToOne
Species where no ortholog for ACRBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACRBP Gene

ENSEMBL:
Gene Tree for ACRBP (if available)
TreeFam:
Gene Tree for ACRBP (if available)

Paralogs for ACRBP Gene

No data available for Paralogs for ACRBP Gene

Variants for ACRBP Gene

Sequence variations from dbSNP and Humsavar for ACRBP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000674503 -- 6,639,706(+) ACAGG(G/T)TTGGG intron-variant
rs1000853958 -- 6,638,475(+) GAGGT(A/G)TCAGA intron-variant
rs1000855335 -- 6,646,643(+) CAATG(-/GAC)TCCAC intron-variant
rs1000945614 -- 6,643,163(+) GATGA(A/G)AGGAG intron-variant
rs1001125348 -- 6,646,377(+) GGGAA(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACRBP Gene

Variant ID Type Subtype PubMed ID
nsv509452 CNV insertion 20534489
nsv557256 CNV loss 21841781
nsv832322 CNV loss 17160897

Variation tolerance for ACRBP Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACRBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACRBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACRBP Gene

Disorders for ACRBP Gene

Relevant External Links for ACRBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACRBP

No disorders were found for ACRBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACRBP Gene

Publications for ACRBP Gene

  1. Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. (PMID: 11248070) Ono T … Nakayama E (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 60
  2. Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells. (PMID: 16301813) Okumura H … Nakayama E (Microbiology and immunology 2005) 3 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. Cancer testis antigen OY-TES-1: analysis of protein expression in ovarian cancer with tissue microarrays. (PMID: 26189257) Fan R … Xie XX (European journal of gynaecological oncology 2015) 3 60

Products for ACRBP Gene

Sources for ACRBP Gene

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