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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACRBP Gene

protein-coding   GIFtS: 44
GCID: GC12M006748

acrosin binding protein

 Explore 3 diseases affiliated with
ACRBP via our new
 Human Malady Compendium 
Biological research products
for ACRBP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Acrosin Binding Protein1 2     Cancer/Testis Antigen OY-TES-12 3
CT231 2 3     Acrosin-Binding Protein2
OY-TES-11 2     Proacrosin Binding Protein Sp322
SP321 2     Proacrosin-Binding Protein Sp323
Cancer/Testis Antigen 232 3     

External Ids:    HGNC: 171951   Entrez Gene: 845192   Ensembl: ENSG000001116447   OMIM: 6083525   UniProtKB: Q8NEB73   

Export aliases for ACRBP gene to outside databases

Previous GC identifers: GC12M006688 GC12M006813 GC12M006626 GC12M006617


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACRBP:
The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig,
and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin
for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the
cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in
testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ACRBP_HUMAN, Q8NEB7
Function: May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its
association with proacrosin (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACRBP gene promoter:
         p53   MyoD   FOXD3   STAT5A   IRF-1   MZF-1   CP2   Pax-4a   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACRBP promoter sequence
   Search SABiosciences Chromatin IP Primers for ACRBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACRBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

ACRBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACRBP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006748:  view genomic region     (about GC identifiers)

Start:
6,747,241 bp from pter      End:
6,756,626 bp from pter
Size:
9,386 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACRBP_HUMAN, Q8NEB7 (See protein sequence)
Recommended Name: Acrosin-binding protein precursor  
Size: 543 amino acids; 61359 Da
Subunit: Binds proacrosin (By similarity)
Subcellular location: Secreted (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity).
Note=Colocalizes with proacrosin in the acrosome of sperm (By similarity)
Secondary accessions: Q9BY87

Explore the universe of human proteins at neXtProt for ACRBP: NX_Q8NEB7

Post-translational modifications:

  • The N-terminus is blocked (By similarity)1
  • Phosphorylated on Tyr residues in capacitated sperm (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NEB7

  • ACRBP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_115878.2  
    ENSEMBL proteins: 
     ENSP00000229243   ENSP00000402725   ENSP00000443153   ENSP00000445262   ENSP00000438656  

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    Uscn Proteins for ACRBP

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--


    ACRBP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACRBP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR009865 Proacrosin-bd

    Graphical View of Domain Structure for InterPro Entry Q8NEB7

    ProtoNet protein and cluster: Q8NEB7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ACRBP_HUMAN, Q8NEB7
    Function: May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its
    association with proacrosin (By similarity)

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    hsa-miR-4314 hsa-miR-330-5p hsa-miR-3199 hsa-miR-326
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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    ACRBP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ACRBP:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Acrbptm1Wen for ACRBP
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Acrbp):
     reproductive system 

    ACRBP for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACRBP

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    ACRBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACRBP
    Search CenterWatch for drugs/clinical trials and news about ACRBP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACRBP gene: 
    NM_032489.2  

    Unigene Cluster for ACRBP:

    Acrosin binding protein
    Hs.123239  [show with all ESTs]
    Unigene Representative Sequence: BC033010
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540513(uc001qpt.1) ENST00000229243(uc001qpu.1 uc010sfg.1)
    ENST00000414226 ENST00000542357 ENST00000536350 ENST00000535884 ENST00000544352
    ENST00000546114 ENST00000538524

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    hsa-miR-4314 hsa-miR-330-5p hsa-miR-3199 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidACRBP 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACRBP
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    Additional cDNA sequence: 

    AB051833.1 AF085884.1 AK302290.1 AK311572.1 AK312782.1 BC033010.2 

    7 DOTS entries:

    DT.75102228  DT.442027  DT.75191868  DT.95114006  DT.95153150  DT.95153152  DT.95153153 

    24/139 AceView cDNA sequences (see all 139):

    BI520181 BI829635 BI825892 BI830145 BC072394 BI520382 AI024421 H91857 
    BI828365 BI832341 BI830966 BI828510 AF085884 BI828527 BI829361 BI826973 
    BI829508 BM553134 BI520377 NM_032489 BC033010 BI829134 BI830306 AJ272207 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ACRBP (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                                                                                        -                 -     -               
    SP2:                          -                                                                                                                     
    SP3:                          -                                                                                                                     
    SP4:                          -           -     -     -     -     -     -     -                                                                     
    SP5:                          -                 -                                                                                                   


    ECgene alternative splicing isoforms for ACRBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACRBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGATGTCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ACRBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACRBP

    SOURCE GeneReport for Unigene cluster: Hs.123239

    UniProtKB/Swiss-Prot: ACRBP_HUMAN, Q8NEB7
    Tissue specificity: Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers,
    including bladder, breast, liver, lung and colon cancers

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ACRBP gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acrbp1 , 5 proacrosin binding protein1, 5 80.52(n)1
    76.07(a)1
      6 (59.17 cM)5
    541371  NM_016845.21  NP_058541.21 
     1250496895 
    chicken
    (Gallus gallus)
    Aves ACRBP6
    Uncharacterized protein
    36(a)
    1 ↔ 1
    1(80192254-80211694)
    lizard
    (Anolis carolinensis)
    Reptilia ACRBP6
    --
    --
    36(a)
    36(a)
    possible ortholog
    1 ↔ 1
    GL343381.1(833624-846386)
    5(11225134-11226225)


    ENSEMBL Gene Tree for ACRBP (if available)
    TreeFam Gene Tree for ACRBP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/209 NCBI SNPs in ACRBP are shown (see all 209    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493120901,2
    C,F,--6747454(+) CATCCG/TAACTG 2 L F mis11Minor allele frequency- T:0.00NA 4552
    rs2021277381,2
    --6747478(+) GTGCTA/GAACTC 2 F syn10--------
    rs1428573261,2
    C,F,--6747495(+) CCATCG/AAAGCA 2 /R /* stg11Minor allele frequency- A:0.00NA 4552
    rs18825531,2
    C,F,O,A,H,--6747578(+) ACACAC/GAGATT 1 -- int124Minor allele frequency- G:0.27EA MN NS NA WA CSA EU 3465
    rs354537561,2
    C--6747645(+) TGTCAG/TAAGCC 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1891681831,2
    --6747659(+) AAGAAC/TGAGAG 1 -- int10--------
    rs1436093091,2
    --6747719(+) GTGGGC/TTTTTA 1 -- int10--------
    rs1480717651,2
    --6747775(+) CAGGCA/GGCTGA 1 -- int10--------
    rs1417348271,2
    --6747809(+) TCCCAC/GGCTAC 1 -- int10--------
    rs1808522291,2
    --6747831(+) GAAGAA/GGAGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ACRBP (6747241 - 6756626 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACRBP: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACRBP for disorders           About GeneDecksing

    OMIM gene information: 608352    OMIM disorders: --

    3 diseases for ACRBP:    About MalaCards
    arteriolosclerosis    cowpox    colon cancer


    Export disorders for ACRBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACRBP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ACRBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. (PubMed id 11248070)1, 2, 3, 9 Ono T.... Nakayama E. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells. (PubMed id 16301813)1, 9 Okumura H....Nakayama E. (2005)
    4. Knockdown of OY-TES-1 by RNAi causes cell cycle arrest and migration decrease in bone marrow-derived mesenchymal stem cells. (PubMed id 22651134)1 Cen Y.H....Xie X.X. (2012)
    5. Tumor antigen acrosin binding protein normalizes mito tic spindle function to promote cancer cell proliferation. (PubMed id 20876808)1 Whitehurst A.W....White M.A. (2010)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Identification of proteins undergoing tyrosine phosphorylation during mouse sperm capacitation. (PubMed id 18649259)9 Arcelay E....Visconti P.E. (2008)
    8. Direct effect of progestogen on gene expression in the testis during gonadotropin withdrawal and early suppression of spermatogenesis. (PubMed id 16621906)9 Walton M.J....Anderson R.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84519 HGNC: 17195 AceView: GPR92andACRBP Ensembl:ENSG00000111644 euGenes: HUgn84519
    ECgene: ACRBP H-InvDB: ACRBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACRBP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACRBP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACRBP gene:
    Search GeneIP for patents involving ACRBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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