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ACR Gene

protein-coding   GIFtS: 56
GCID: GC22P051176

Acrosin

  See ACR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
acrosin1 2     proacrosin2
Acrosin Light And Heavy Chain Prepropeptide1 2     ACRS3
preproacrosin1 2     EC 3.4.218
EC 3.4.21.103 8     

External Ids:    HGNC: 1261   Entrez Gene: 492   Ensembl: ENSG000001003127   OMIM: 1024805   UniProtKB: P103233   

Export aliases for ACR gene to outside databases

Previous GC identifers: GC22P047680 GC22P049309 GC22P049466 GC22P034069


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACR Gene:
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase
with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme
functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost
glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of
spermatogenesis. In humans proacrosin first appears in the haploid spermatids. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACR Gene:
ACR (acrosin) is a protein-coding gene. Diseases associated with ACR include male infertility due to acrosin deficiency, and globozoospermia. GO annotations related to this gene include drug binding and serine-type endopeptidase activity. An important paralog of this gene is PRSS56.

UniProtKB/Swiss-Prot: ACRO_HUMAN, P10323
Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage
specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome

Gene Wiki entry for ACR (Acrosin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011526.8  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACR gene promoter:
         GR   GR-beta   GR-alpha   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACR promoter sequence
   Search Chromatin IP Primers for ACR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

ACR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACR gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P051176:  view genomic region     (about GC identifiers)

Start:
51,176,624 bp from pter      End:
51,183,762 bp from pter
Size:
7,139 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ACRO_HUMAN, P10323 (See protein sequence)
Recommended Name: Acrosin precursor  
Size: 421 amino acids; 45847 Da
Subunit: Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with
SERPINA5
Secondary accessions: Q6ICK2

Explore the universe of human proteins at neXtProt for ACR: NX_P10323

Explore proteomics data for ACR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn22, Asn210
  • Selected DME Specific Peptides for ACR (P10323) (see all 10)
     WIASKIG  GDSGGPL  VGITSWG  VLTAAHC 


    See ACR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001088.2  
    ENSEMBL proteins: 
     ENSP00000216139   ENSP00000435120  
    Reactome Protein details: P10323

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    antibodies-online proteins for ACR (7 products) 

     
    antibodies-online peptides for ACR

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR012267 Pept_S1A_acrosin
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P10323

    ProtoNet protein and cluster: P10323

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: ACRO_HUMAN, P10323
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with ACR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACRO_HUMAN, P10323
    Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage
    specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome
    Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa
    Enzyme regulation: Inhibited by SERPINA5

         Genatlas biochemistry entry for ACR:
    acrosin

         Enzyme Numbers (IUBMB): EC 3.4.21.101 2 EC 3.4.212

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS1937464
    GO:0003824catalytic activity ----
    GO:0004040amidase activity ISS--
    GO:0004252serine-type endopeptidase activity IDA6802470
    GO:0005507copper ion binding NAS6815104
         
    Find genes that share ontologies with ACR           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ACR:
     Increased number of cells in m  Metaphase cells 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Acr):
     normal  reproductive system 

    Find genes that share phenotypes with ACR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ACR: Acrtm1Tba Acrtm1Wen

       genOway: Develop your customized and physiologically relevant rodent model for ACR

    miRNA
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    miRTarBase miRNAs that target ACR:
    hsa-mir-335-5p (MIRT018926)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole4
    extracellular3
    golgi apparatus2
    plasma membrane2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle ----
    GO:0005576extracellular region TAS--
    GO:0005798Golgi-associated vesicle IEA--
    GO:0043159acrosomal matrix TAS12398221
    GO:0043234protein complex IDA7521127

    Find genes that share ontologies with ACR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACR About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Acrosome Reaction0.00
    Fertilization1.00


    Find genes that share SuperPaths with ACR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ACR
        Acrosome Reaction


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACR
    Interactions:

        GeneGlobe Interaction Network for ACR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ACR (P103233 ENSP000002161394) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZP2Q059963, ENSP000002195934I2D: score=4 STRING: ENSP00000219593
    SERPINA5P051543, ENSP000003332034I2D: score=2 STRING: ENSP00000333203
    ZP3P217543, ENSP000003783264I2D: score=2 STRING: ENSP00000378326
    E2F4ENSP000003686864STRING: ENSP00000368686
    HPENSP000003481704STRING: ENSP00000348170
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002077acrosome matrix dispersal NAS10418103
    GO:0006508proteolysis ----
    GO:0007190activation of adenylate cyclase activity IDA3880736
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida IEA--

    Find genes that share ontologies with ACR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACR (ACRO)

    Selected Novoseek inferred chemical compound relationships for ACR gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    baee 75.9 4 15192063 (1)
    fucoidan 70.5 9 10418103 (3), 8182587 (2), 10819753 (1), 1652426 (1) (see all 6)
    p-amino benzamidine 62.2 1 2264993 (1)
    benzamidine 59.6 2 11665890 (2)
    serine 55.1 30 18247330 (2), 1783391 (2), 9035970 (1), 1661689 (1) (see all 22)
    sbti 55 3 8439623 (2)
    chymostatin 45.3 1 11754025 (1)
    percoll 42.9 4 15148920 (4)
    dextran sulfate 34.9 2 8182587 (2)
    suramin 27.6 5 9239672 (2), 8809344 (2)



    Find genes that share compounds with ACR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACR gene: 
    NM_001097.2  

    Unigene Cluster for ACR:

    Acrosin
    Hs.370870  [show with all ESTs]
    Unigene Representative Sequence: Y00970
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533930(uc010hbh.1) ENST00000216139(uc003bnh.4) ENST00000529621
    ENST00000527761
    miRNA
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    Additional mRNA sequence: 

    AK310316.1 CR456366.1 Y00970.1 

    2 DOTS entries:

    DT.210449  DT.120933756 

    15 AceView cDNA sequences:

    AA758980 AA416966 CR456366 BV183894 Y00970 NM_001097 BG724168 BI831746 
    BV200546 AI143948 AI990325 AA758820 AI143947 AW589590 AA813569 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ACR Expression
    About this image


    ACR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Long-time differentiated EBs
             testis ; cells in seminiferous ducts   
     
     NULL (Uncategorized)
             Short-term differentiated embryoid bodies
     
     Ovary (Reproductive System)
             Oviduct
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES-J1
    ACR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370870
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ACR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acr1 , 5 acrosin prepropeptide1, 5 74.15(n)1
    69.02(a)1
      15 (44.96 cM)5
    114341  NM_013455.31  NP_038483.11 
     895683265 
    chicken
    (Gallus gallus)
    Aves LOC7691761 acrosin-like 55.32(n)
    46.28(a)
      769176  XM_003640319.2  XP_003640367.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    many ↔ many
    GL343287.1(1517504-1579414)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017326141 acrosin-like 58.88(n)
    54.89(a)
      101732614  XM_004915638.1  XP_004915695.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmprss126
    transmembrane (C-terminal) protease, serine 12
    35(a)
    1 ↔ 1
    23(27586463-27591466) ENSDARG00000093100
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343506
    CG82136
    (see all 30)
    --
    9(a)
    5(a)
    (see all 30)
    many ↔ many
    many ↔ many
    (see all 30)
    2R(4881047-4894092)
    2R(4856841-4873063)


    ENSEMBL Gene Tree for ACR (if available)
    TreeFam Gene Tree for ACR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACR gene
    PRSS562  TMPRSS122  OVCH22  OVCH12  
    Selected SIMAP similar genes for ACR using alignment to 2 protein entries:     ACRO_HUMAN (see all proteins) (see all similar genes):
    CELA2B    PRSS1    KLKB1    TMPRSS11D    TMPRSS5    KLK9
    PRSS45    TMPRSS11A    TMPRSS3    TMPRSS11B    TMPRSS11F    ELA2A
    TMPRSS2    CELA3A    PRSS55    TMPRSS13    HPN    TPSG1

    Find genes that share paralogs with ACR           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ACR
    PGOHUM00000240267


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACR (see all 171)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60100671,2
    C,F--51178607(+) GGGGGG/CGCTGA 1 -- int12Minor allele frequency- C:0.07NA EA 240
    rs581094831,2
    C,F--51178688(+) GCCCAG/AGCTGC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1418449651,2
    C--51178756(+) AGGTTA/TTGTGG 1 -- int10--------
    rs1458001541,2
    --51178843(+) CAAGCC/TGACCA 1 -- int10--------
    rs1481929551,2
    --51178938(+) CATAGC/TACCAA 1 -- int10--------
    rs22836751,2
    C,F,A--51179000(+) GGGACC/AGGTGG 1 -- int17Minor allele frequency- A:0.45NA WA CSA EA 249
    rs1402370691,2
    C--51179029(+) GGTCAC/TAGGCA 1 -- int10--------
    rs1917364101,2
    --51179030(+) GTCATA/CGGCAT 1 -- int10--------
    rs599986031,2
    C,F--51179190(+) ACACTC/TGACAC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs40400421,2
    C--51179307(+) AGAGAC/G/TGCCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ACR (51176624 - 51183762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ACR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428394CNV Loss18775914
    dgv784n67CNV Gain20364138
    essv13762CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ACR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 102480    OMIM disorders: --

    2 diseases for ACR:    
    About MalaCards
    male infertility due to acrosin deficiency    globozoospermia

    3 diseases from the University of Copenhagen DISEASES database for ACR:
    Infertility     Male infertility     Varicocele

    Find genes that share disorders with ACR           About GenesLikeMe

    5 Novoseek inferred disease relationships for ACR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    globozoospermia 63.5 2 16833197 (2)
    infertility 51 22 18439585 (4), 12931362 (2), 9111883 (2), 11994540 (2) (see all 11)
    infertility male 48 2 15652894 (1), 16145435 (1)
    oligozoospermia 46.5 3 7559161 (1), 2121108 (1)
    varicocele 32.1 3 12390086 (1), 8822441 (1)


    Export disorders for ACR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACR gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with ACR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human preproacrosin cDNA. (PubMed id 2298447)1, 2, 3, 9 Adham I.M.... Engel W. (Hum. Genet. 1990)
    2. Evaluation of the proacrosin/acrosin system and its mechanism of activation in human sperm extracts. (PubMed id 11839395)1, 2, 9 Zahn A.... Vazquez-Levin M.H. (J. Reprod. Immunol. 2002)
    3. Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa. (PubMed id 7521127)1, 2, 9 Zheng X.... Binder B.R. (Am. J. Physiol. 1994)
    4. Molecular cloning, sequencing and restriction mapping of the genomic sequence encoding human proacrosin. (PubMed id 1628652)1, 2, 9 Vazquez-Levin M.H.... Gordon J.W. (Eur. J. Biochem. 1992)
    5. Nucleotide sequence and exon-intron organization of the human proacrosin gene. (PubMed id 2114285)1, 2, 9 Keime S.... Engel W. (Eur. J. Biochem. 1990)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. Role of acrosomal matrix proteases in sperm-zona pellucida interactions. (PubMed id 12398221)1, 3 Honda A....Baba T. (Hum. Reprod. Update 2002)
    8. Primary structure of human proacrosin deduced from its cDNA sequence. (PubMed id 2493394)1, 2 Baba T.... Arai Y. (FEBS Lett. 1989)
    9. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PubMed id 15950651)1, 9 Furlong L.I....Vazquez-Levin M.H. (Fertil. Steril. 2005)
    10. Binding of recombinant human proacrosin/acrosin to zona pellucida glycoproteins. II. Participation of mannose residues in the interaction. (PubMed id 15950652)1, 9 Furlong L.I....Vazquez-Levin M.H. (Fertil. Steril. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 49 HGNC: 126 AceView: ACR Ensembl:ENSG00000100312 euGenes: HUgn49
    ECgene: ACR H-InvDB: ACR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ACR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ACR gene:
    Search GeneIP for patents involving ACR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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