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Aliases for ACR Gene

Aliases for ACR Gene

  • Acrosin 2 3 5
  • Acrosin Light And Heavy Chain Prepropeptide 2 3
  • Preproacrosin 2 3
  • EC 3.4.21.10 4 63
  • Proacrosin 3
  • EC 3.4.21 63
  • ACRS 4

External Ids for ACR Gene

Previous GeneCards Identifiers for ACR Gene

  • GC22P047680
  • GC22P049309
  • GC22P049466
  • GC22P051176
  • GC22P034069

Summaries for ACR Gene

Entrez Gene Summary for ACR Gene

  • Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACR Gene

ACR (Acrosin) is a Protein Coding gene. Diseases associated with ACR include male infertility and spermatogenic failure 6. Among its related pathways are Reproduction. GO annotations related to this gene include serine-type endopeptidase activity and drug binding. An important paralog of this gene is ST14.

UniProtKB/Swiss-Prot for ACR Gene

  • Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Gene Wiki entry for ACR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACR Gene

Genomics for ACR Gene

Regulatory Elements for ACR Gene

Genomic Location for ACR Gene

Chromosome:
22
Start:
50,738,196 bp from pter
End:
50,745,334 bp from pter
Size:
7,139 bases
Orientation:
Plus strand

Genomic View for ACR Gene

Genes around ACR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACR Gene

Proteins for ACR Gene

  • Protein details for ACR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10323-ACRO_HUMAN
    Recommended name:
    Acrosin
    Protein Accession:
    P10323
    Secondary Accessions:
    • Q6ICK2

    Protein attributes for ACR Gene

    Size:
    421 amino acids
    Molecular mass:
    45847 Da
    Quaternary structure:
    • Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5.

neXtProt entry for ACR Gene

Proteomics data for ACR Gene at MOPED

Post-translational modifications for ACR Gene

  • Glycosylation at Asn 22 and Asn 210

Other Protein References for ACR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ACR Gene

Suggested Antigen Peptide Sequences for ACR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10323

UniProtKB/Swiss-Prot:

ACRO_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with ACR: view

No data available for Gene Families for ACR Gene

Function for ACR Gene

Molecular function for ACR Gene

GENATLAS Biochemistry:
acrosin
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5.
UniProtKB/Swiss-Prot Function:
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Enzyme Numbers (IUBMB) for ACR Gene

Gene Ontology (GO) - Molecular Function for ACR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042806 fucose binding ISS --
genes like me logo Genes that share ontologies with ACR: view
genes like me logo Genes that share phenotypes with ACR: view

Animal Models for ACR Gene

MGI Knock Outs for ACR:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACR

miRNA for ACR Gene

miRTarBase miRNAs that target ACR

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACR Gene

Localization for ACR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACR Gene COMPARTMENTS Subcellular localization image for ACR gene
Compartment Confidence
extracellular 5
nucleus 5
vacuole 5
golgi apparatus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005798 Golgi-associated vesicle IEA --
genes like me logo Genes that share ontologies with ACR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACR Gene

Pathways & Interactions for ACR Gene

SuperPathways for ACR Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ACR: view

Pathways by source for ACR Gene

3 Reactome pathways for ACR Gene

Gene Ontology (GO) - Biological Process for ACR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002077 acrosome matrix dispersal NAS 10418103
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ACR: view

No data available for SIGNOR curated interactions for ACR Gene

Drugs & Compounds for ACR Gene

(31) Drugs for ACR Gene - From: Novoseek and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma 139
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR, Cytotoxic agent 1444
Analgesics Pharma 9358
Analgesics, Non-Narcotic Pharma 5184
Antibodies Pharma 4477

(17) Additional Compounds for ACR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACR: view

Transcripts for ACR Gene

mRNA/cDNA for ACR Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACR Gene

Acrosin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACR Gene

No ASD Table

Relevant External Links for ACR Gene

GeneLoc Exon Structure for
ACR
ECgene alternative splicing isoforms for
ACR

Expression for ACR Gene

mRNA expression in normal human tissues for ACR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACR Gene

This gene is overexpressed in Testis (x34.4).

Protein differential expression in normal tissues from HIPED for ACR Gene

This gene is overexpressed in Testis (55.2) and Ovary (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACR Gene



SOURCE GeneReport for Unigene cluster for ACR Gene Hs.370870

genes like me logo Genes that share expression patterns with ACR: view

Protein tissue co-expression partners for ACR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ACR Gene

Orthologs for ACR Gene

This gene was present in the common ancestor of animals.

Orthologs for ACR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACR 35
  • 76.35 (n)
  • 68.52 (a)
ACR 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACR 35
  • 79.42 (n)
  • 72.64 (a)
ACR 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acr 35
  • 74.15 (n)
  • 69.02 (a)
Acr 16
Acr 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACR 35
  • 90.85 (n)
  • 86.62 (a)
ACR 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acr 35
  • 74.81 (n)
  • 69.27 (a)
oppossum
(Monodelphis domestica)
Mammalia ACR 36
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC769176 35
  • 55.32 (n)
  • 46.28 (a)
-- 36
  • 41 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732614 35
  • 58.88 (n)
  • 54.89 (a)
zebrafish
(Danio rerio)
Actinopterygii tmprss12 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11668 36
  • 18 (a)
ManyToMany
CG11670 36
  • 17 (a)
ManyToMany
CG11836 36
  • 32 (a)
ManyToMany
CG11841 36
  • 24 (a)
ManyToMany
CG11842 36
  • 24 (a)
ManyToMany
CG11843 36
  • 26 (a)
ManyToMany
CG1299 36
  • 16 (a)
ManyToMany
CG14642 36
  • 17 (a)
ManyToMany
CG14892 36
  • 19 (a)
ManyToMany
CG18735 36
  • 23 (a)
ManyToMany
CG31728 36
  • 13 (a)
ManyToMany
CG32260 36
  • 15 (a)
ManyToMany
CG3355 36
  • 27 (a)
ManyToMany
CG34350 36
  • 9 (a)
ManyToMany
CG3700 36
  • 21 (a)
ManyToMany
CG4386 36
  • 22 (a)
ManyToMany
CG4613 36
  • 24 (a)
ManyToMany
CG4914 36
  • 25 (a)
ManyToMany
CG4927 36
  • 21 (a)
ManyToMany
CG6361 36
  • 13 (a)
ManyToMany
CG6865 36
  • 29 (a)
ManyToMany
CG7432 36
  • 11 (a)
ManyToMany
CG8172 36
  • 14 (a)
ManyToMany
CG8213 36
  • 5 (a)
ManyToMany
CG9294 36
  • 25 (a)
ManyToMany
CG9372 36
  • 23 (a)
ManyToMany
psh 36
  • 21 (a)
ManyToMany
Sb 36
  • 11 (a)
ManyToMany
snk 36
  • 19 (a)
ManyToMany
spirit 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
Species with no ortholog for ACR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACR Gene

ENSEMBL:
Gene Tree for ACR (if available)
TreeFam:
Gene Tree for ACR (if available)

Paralogs for ACR Gene

Pseudogenes.org Pseudogenes for ACR Gene

genes like me logo Genes that share paralogs with ACR: view

Variants for ACR Gene

Sequence variations from dbSNP and Humsavar for ACR Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_011650 -
VAR_011651 -
rs1064736 -- 50,744,173(+) TGCGC(A/C/G)GGGTA reference, synonymous-codon
rs1064738 -- 50,744,975(+) GCCCC(C/G)ACCCC reference, missense
rs3964373 -- 50,741,244(+) GTCAC(C/T)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACR Gene

Variant ID Type Subtype PubMed ID
dgv784n67 CNV Gain 20364138
essv13762 CNV CNV 17122850
nsv428394 CNV Loss 18775914

Variation tolerance for ACR Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACR Gene

HapMap Linkage Disequilibrium report
ACR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACR Gene

Disorders for ACR Gene

MalaCards: The human disease database

(3) MalaCards diseases for ACR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
spermatogenic failure 6
  • spermatogenic failure 9
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search ACR in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACR
genes like me logo Genes that share disorders with ACR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACR Gene

Publications for ACR Gene

  1. Molecular cloning of human preproacrosin cDNA. (PMID: 2298447) Adham I.M. … Engel W. (Hum. Genet. 1990) 2 3 4 23 67
  2. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PMID: 15950651) Furlong L.I. … Vazquez-Levin M.H. (Fertil. Steril. 2005) 3 23
  3. Binding of recombinant human proacrosin/acrosin to zona pellucida glycoproteins. II. Participation of mannose residues in the interaction. (PMID: 15950652) Furlong L.I. … Vazquez-Levin M.H. (Fertil. Steril. 2005) 3 23
  4. Biochemical and molecular studies of the proacrosin/acrosin system in patients with unexplained infertility. (PMID: 12801583) MarA- S.I. … Vazquez-Levin M.H. (Fertil. Steril. 2003) 3 23
  5. [The effect of semen antisperm antibody on human sperm acrosin activity]. (PMID: 12931362) Liu R.Z. … Wang Z.S. (Zhonghua Nan Ke Xue 2003) 3 23

Products for ACR Gene

Sources for ACR Gene

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