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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACR Gene

protein-coding   GIFtS: 55
GCID: GC22P051176

Acrosin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
acrosin1 2     proacrosin2
Acrosin Light And Heavy Chain Prepropeptide1 2     ACRS3
preproacrosin1 2     EC 3.4.218
EC 3.4.21.103 8     

External Ids:    HGNC: 1261   Entrez Gene: 492   Ensembl: ENSG000001003127   OMIM: 1024805   UniProtKB: P103233   

Export aliases for ACR gene to outside databases

Previous GC identifers: GC22P047680 GC22P049309 GC22P049466 GC22P034069


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACR Gene:
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase
with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme
functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost
glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of
spermatogenesis. In humans proacrosin first appears in the haploid spermatids. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACR Gene: 
ACR (acrosin) is a protein-coding gene. Diseases associated with ACR include globozoospermia, and varicocele, and among its related super-pathways are Interaction With The Zona Pellucida. GO annotations related to this gene include drug binding and serine-type endopeptidase activity. An important paralog of this gene is CFI.

UniProtKB/Swiss-Prot: ACRO_HUMAN, P10323
Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage
specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome

Gene Wiki entry for ACR (Acrosin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011526.7  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACR gene promoter:
         GR   GR-beta   GR-alpha   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACR promoter sequence
   Search SABiosciences Chromatin IP Primers for ACR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

ACR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACR gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P051176:  view genomic region     (about GC identifiers)

Start:
51,176,624 bp from pter      End:
51,183,762 bp from pter
Size:
7,139 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACRO_HUMAN, P10323 (See protein sequence)
Recommended Name: Acrosin precursor  
Size: 421 amino acids; 45847 Da
Subunit: Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with
SERPINA5
Secondary accessions: Q6ICK2

Explore the universe of human proteins at neXtProt for ACR: NX_P10323

Explore proteomics data for ACR at MOPED 

4/10 DME Specific Peptides for ACR (P10323) (see all 10)
 WIASKIG  GDSGGPL  VGITSWG  VLTAAHC 

ACR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ACR Protein Expression
REFSEQ proteins: NP_001088.2  
ENSEMBL proteins: 
 ENSP00000216139   ENSP00000435120  
Reactome Protein details: P10323
Human Recombinant Protein Products for ACR: 
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Cloud-Clone Corp. Proteins for ACR 

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001669acrosomal vesicle ----
GO:0005576extracellular region TAS--
GO:0005798Golgi-associated vesicle IEA--
GO:0043159acrosomal matrix TAS12398221
GO:0043234protein complex IDA7521127

ACR for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR009003 Trypsin-like_Pept_dom
 IPR001254 Peptidase_S1
 IPR012267 Pept_S1A_acrosin
 IPR018114 Peptidase_S1_AS

Graphical View of Domain Structure for InterPro Entry P10323

ProtoNet protein and cluster: P10323

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: ACRO_HUMAN, P10323
Similarity: Belongs to the peptidase S1 family
Similarity: Contains 1 peptidase S1 domain


ACR for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ACRO_HUMAN, P10323
Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage
specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome
Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa
Enzyme regulation: Inhibited by SERPINA5

     Genatlas biochemistry entry for ACR:
acrosin

     Enzyme Numbers (IUBMB): EC 3.4.21.101 2 EC 3.4.212

     Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding NAS1937464
GO:0003824catalytic activity ----
GO:0004040amidase activity ISS--
GO:0004252serine-type endopeptidase activity IDA6802470
GO:0005507copper ion binding NAS6815104
     
ACR for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ACR:
 Increased number of cells in m  Metaphase cells 

     2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Acr):
 normal  reproductive system 

ACR for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for ACR: Acrtm1Tba Acrtm1Wen

   inGenious Targeting Laboratory - Custom generated mouse model solutions for ACR 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ACR About                                                                                                See pathways by source

SuperPathContained pathways About
1Fertilization
Fertilization0.38
Reproduction0.38
2Acrosome Reaction
Acrosome Reaction

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


3        Reactome Pathways for ACR
    Fertilization
Reproduction
Acrosome Reaction



ACR for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACR

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for ACR (P103233 ENSP000002161394) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ZP2Q059963, ENSP000002195934I2D: score=4 STRING: ENSP00000219593
SERPINA5P051543, ENSP000003332034I2D: score=2 STRING: ENSP00000333203
ZP3P217543, ENSP000003783264I2D: score=2 STRING: ENSP00000378326
E2F4ENSP000003686864STRING: ENSP00000368686
About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002077acrosome matrix dispersal NAS10418103
GO:0006508proteolysis ----
GO:0007190activation of adenylate cyclase activity IDA3880736
GO:0007338single fertilization TAS--
GO:0007339binding of sperm to zona pellucida IEA--

ACR for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ACR for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACR (ACRO)

10/34 Novoseek inferred chemical compound relationships for ACR gene (see all 34)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
baee 75.9 4 15192063 (1)
fucoidan 70.5 9 10418103 (3), 8182587 (2), 10819753 (1), 1652426 (1) (see all 6)
p-amino benzamidine 62.2 1 2264993 (1)
benzamidine 59.6 2 11665890 (2)
serine 55.1 30 18247330 (2), 1783391 (2), 9035970 (1), 1661689 (1) (see all 22)
sbti 55 3 8439623 (2)
chymostatin 45.3 1 11754025 (1)
percoll 42.9 4 15148920 (4)
dextran sulfate 34.9 2 8182587 (2)
suramin 27.6 5 9239672 (2), 8809344 (2)

Search CenterWatch for drugs/clinical trials and news about ACR / ACRO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACR gene: 
NM_001097.2  

Unigene Cluster for ACR:

Acrosin
Hs.370870  [show with all ESTs]
Unigene Representative Sequence: Y00970
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000533930(uc010hbh.1) ENST00000216139(uc003bnh.4) ENST00000529621
ENST00000527761
miRNA
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Inhib. RNA
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OriGene RNAi products in human, mouse, rat for ACR
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACR
Clone
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GenScript: all cDNA clones in your preferred vector: ACR (NM_001097)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACR
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACR
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                     Customized lentivirus expression plasmids for stable overexpression of ACR 
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACR
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACR
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACR

Additional mRNA sequence: 

AK310316.1 CR456366.1 Y00970.1 

2 DOTS entries:

DT.210449  DT.120933756 

15 AceView cDNA sequences:

CR456366 AA758980 AA416966 Y00970 BV183894 BV200546 BI831746 BG724168 
NM_001097 AA758820 AI990325 AI143947 AI143948 AA813569 AW589590 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACR expression in normal human tissues (normalized intensities)      ACR embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ACR Expression
About this image


ACR expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand (Reproductive System)
 
 Testis (Reproductive System)
         testis ; cells in seminiferus ducts   
 
 Inner Cell Mass (Early Embryonic Tissues)
         ES-J1
         fallopian tube ; glandular cells   

See ACR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACR

SOURCE GeneReport for Unigene cluster: Hs.370870
    SABiosciences Custom PCR Arrays for ACR
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACR

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ACR gene from 4/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Acr1 , 5 acrosin prepropeptide1, 5 76.59(n)1
72.77(a)1
  15 (44.96 cM)5
114341  NM_013455.31  NP_038483.11 
 895683265 
chicken
(Gallus gallus)
Aves ACR1 acrosin 54.58(n)
45.63(a)
  426864  XM_003640318.1  XP_003640366.1 
zebrafish
(Danio rerio)
Actinopterygii tmprss126
si:dkey-9p24.56
si:dkey-9p24.5
35(a)
23(a)
1 ↔ 1
possible ortholog
23(27586463-27591466)
23(27592709-27597315)
fruit fly
(Drosophila melanogaster)
Insecta CG118366
ndl6
(see all 3)
nudel
(see all 3)
32(a)
3(a)
(see all 3)
possible ortholog
possible ortholog
(see all 3)
3R(20896853-20898434)
3L(6587038-6596466)


ENSEMBL Gene Tree for ACR (if available)
TreeFam Gene Tree for ACR (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ACR gene
CFI2  PRSS562  CORIN2  TMPRSS122  
18/40 SIMAP similar genes for ACR using alignment to 2 protein entries:     ACRO_HUMAN (see all proteins) (see all similar genes):
CELA2B    PRSS1    KLKB1    TMPRSS11D    TMPRSS5    KLK9
PRSS45    TMPRSS11A    TMPRSS3    TMPRSS11B    TMPRSS11F    ELA2A
TMPRSS2    CELA3A    PRSS55    TMPRSS13    HPN    TPSG1

ACR for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ACR
PGOHUM00000240267


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/171 SNPs in ACR are shown (see all 171)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0116514
----see VAR_0116512 F L mis40--------
VAR_0116504
----see VAR_0116502 L V mis40--------
rs60100671,2
C,F--51178607(+) GGGGGG/CGCTGA 1 -- int12Minor allele frequency- C:0.07NA EA 240
rs581094831,2
C,F--51178688(+) GCCCAG/AGCTGC 1 -- int11Minor allele frequency- A:0.50WA 2
rs1418449651,2
C--51178756(+) AGGTTA/TTGTGG 1 -- int10--------
rs1458001541,2
--51178843(+) CAAGCC/TGACCA 1 -- int10--------
rs1481929551,2
--51178938(+) CATAGC/TACCAA 1 -- int10--------
rs22836751,2
C,F,A--51179000(+) GGGACC/AGGTGG 1 -- int17Minor allele frequency- A:0.45NA WA CSA EA 249
rs1402370691,2
C--51179029(+) GGTCAC/TAGGCA 1 -- int10--------
rs1917364101,2
--51179030(+) GTCATA/CGGCAT 1 -- int10--------

HapMap Linkage Disequilibrium report for ACR (51176624 - 51183762 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ACR:    About this table     
Variant IDTypeSubtypePubMed ID
nsv428394CNV Loss18775914
dgv784n67CNV Gain20364138
essv13762CNV CNV17122850

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 102480    OMIM disorders: --

7 diseases for ACR:    About MalaCards
globozoospermia    varicocele    male infertility    vaginitis
infertility    epididymitis    endotheliitis

3 diseases from the University of Copenhagen DISEASES database for ACR:
Infertility     Male infertility     Varicocele

ACR for disorders           About GeneDecksing

5 Novoseek inferred disease relationships for ACR gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
globozoospermia 63.5 2 16833197 (2)
infertility 51 22 18439585 (4), 12931362 (2), 9111883 (2), 11994540 (2) (see all 11)
infertility male 48 2 15652894 (1), 16145435 (1)
oligozoospermia 46.5 3 7559161 (1), 2121108 (1)
varicocele 32.1 3 12390086 (1), 8822441 (1)


Export disorders for ACR gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ACR gene, integrated from 9 sources (see all 165):
(articles sorted by number of sources associating them with ACR)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of human preproacrosin cDNA. (PubMed id 2298447)1, 2, 3, 9 Adham I.M.... Engel W. (1990)
  2. Evaluation of the proacrosin/acrosin system and its mechanism of activation in human sperm extracts. (PubMed id 11839395)1, 2, 9 Zahn A.... Vazquez-Levin M.H. (2002)
  3. Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa. (PubMed id 7521127)1, 2, 9 Zheng X....Binder B.R. (1994)
  4. Molecular cloning, sequencing and restriction mapping of the genomic sequence encoding human proacrosin. (PubMed id 1628652)1, 2, 9 Vazquez-Levin M.H.... Gordon J.W. (1992)
  5. Nucleotide sequence and exon-intron organization of the human proacrosin gene. (PubMed id 2114285)1, 2, 9 Keime S.... Engel W. (1990)
  6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
  7. Role of acrosomal matrix proteases in sperm-zona pellucida interactions. (PubMed id 12398221)1, 3 Honda A....Baba T. (2002)
  8. Primary structure of human proacrosin deduced from its cDNA sequence. (PubMed id 2493394)1, 2 Baba T.... Arai Y. (1989)
  9. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PubMed id 15950651)1, 9 Furlong L.I....Vazquez-Levin M.H. (2005)
  10. Binding of recombinant human proacrosin/acrosin to zona pellucida glycoproteins. II. Participation of mannose residues in the interaction. (PubMed id 15950652)1, 9 Furlong L.I....Vazquez-Levin M.H. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 49 HGNC: 126 AceView: ACR Ensembl:ENSG00000100312 euGenes: HUgn49
ECgene: ACR H-InvDB: ACR

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for ACR Pharmacogenomics, SNPs, Pathways

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