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Aliases for ACPT Gene

Aliases for ACPT Gene

  • Acid Phosphatase, Testicular 2 3
  • EC 3.1.3.2 4 64

External Ids for ACPT Gene

Summaries for ACPT Gene

Entrez Gene Summary for ACPT Gene

  • Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACPT Gene

ACPT (Acid Phosphatase, Testicular) is a Protein Coding gene. Diseases associated with ACPT include prostate cancer and testicular cancer. Among its related pathways are Riboflavin metabolism. GO annotations related to this gene include acid phosphatase activity. An important paralog of this gene is ACPP.

UniProtKB/Swiss-Prot for ACPT Gene

  • Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACPT Gene

Genomics for ACPT Gene

Genomic Location for ACPT Gene

Start:
50,790,415 bp from pter
End:
50,795,224 bp from pter
Size:
4,810 bases
Orientation:
Plus strand

Genomic View for ACPT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACPT Gene

Regulatory Elements for ACPT Gene

Proteins for ACPT Gene

  • Protein details for ACPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZG2-PPAT_HUMAN
    Recommended name:
    Testicular acid phosphatase
    Protein Accession:
    Q9BZG2
    Secondary Accessions:
    • C0H3P7
    • Q9BZG3
    • Q9BZG4

    Protein attributes for ACPT Gene

    Size:
    426 amino acids
    Molecular mass:
    46090 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for ACPT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACPT Gene

Proteomics data for ACPT Gene at MOPED

Selected DME Specific Peptides for ACPT Gene

Post-translational modifications for ACPT Gene

Other Protein References for ACPT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ACPT Gene

Protein Domains for ACPT Gene

UniProtKB/Swiss-Prot:

PPAT_HUMAN
Family:
  • Belongs to the histidine acid phosphatase family.:
    • Q9BZG2
genes like me logo Genes that share domains with ACPT: view

No data available for Gene Families for ACPT Gene

Function for ACPT Gene

Molecular function for ACPT Gene

UniProtKB/Swiss-Prot CatalyticActivity: A phosphate monoester + H(2)O = an alcohol + phosphate
UniProtKB/Swiss-Prot Function: Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.
UniProtKB/Swiss-Prot Induction: Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated by estrogen and progestin.

Enzyme Numbers (IUBMB) for ACPT Gene

Gene Ontology (GO) - Molecular Function for ACPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IEA --
genes like me logo Genes that share ontologies with ACPT: view

miRNA for ACPT Gene

miRTarBase miRNAs that target ACPT

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACPT Gene

Localization for ACPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACPT Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACPT Gene COMPARTMENTS Subcellular localization image for ACPT gene
Compartment Confidence
chloroplast 2
endoplasmic reticulum 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ACPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ACPT: view

Pathways for ACPT Gene

SuperPathways for ACPT Gene

Superpath Contained pathways
1 Riboflavin metabolism
genes like me logo Genes that share pathways with ACPT: view

Pathways by source for ACPT Gene

1 KEGG pathway for ACPT Gene

Interacting Proteins for ACPT Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270593%0d%0a9606.ENSP00000350265%0d%0a9606.ENSP00000292180%0d%0a9606.ENSP00000354238%0d%0a
Selected Interacting proteins: ENSP00000270593 for ACPT Gene via STRING

Gene Ontology (GO) - Biological Process for ACPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with ACPT: view

Compounds for ACPT Gene

(13) HMDB Compounds for ACPT Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
4-Nitrophenol
  • 1-Hydroxy-4-nitrobenzene
100-02-7
Ethanol
  • 1-Hydroxyethane
64-17-5
genes like me logo Genes that share compounds with ACPT: view

Transcripts for ACPT Gene

mRNA/cDNA for ACPT Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACPT Gene

Acid phosphatase, testicular:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACPT Gene

No ASD Table

Relevant External Links for ACPT Gene

GeneLoc Exon Structure for
ACPT
ECgene alternative splicing isoforms for
ACPT

Expression for ACPT Gene

mRNA expression in normal human tissues for ACPT Gene

mRNA differential expression in normal tissues according to GTEx for ACPT Gene

This gene is overexpressed in Testis (26.7) and Skin - Not Sun Exposed (Suprapubic) (4.3).

SOURCE GeneReport for Unigene cluster for ACPT Gene Hs.293394

mRNA Expression by UniProt/SwissProt for ACPT Gene

Q9BZG2-PPAT_HUMAN
Tissue specificity: Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow.
genes like me logo Genes that share expressions with ACPT: view

Orthologs for ACPT Gene

This gene was present in the common ancestor of animals.

Orthologs for ACPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACPT 36
  • 99.62 (n)
  • 99.44 (a)
ACPT 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACPT 36
  • 85.49 (n)
  • 87.53 (a)
ACPT 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACPT 36
  • 86.9 (n)
  • 88.31 (a)
ACPT 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acpt 36
  • 83.29 (n)
  • 86.15 (a)
Acpt 16
Acpt 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACPT 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acpt 36
  • 82.84 (n)
  • 84.07 (a)
lizard
(Anolis carolinensis)
Reptilia ACPT 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494856 36
  • 59.57 (n)
  • 56.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acph-1 37
  • 28 (a)
ManyToMany
CG6656 37
  • 27 (a)
ManyToMany
CG9449 37
  • 28 (a)
ManyToMany
CG9451 37
  • 26 (a)
ManyToMany
CG9452 37
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acp-1 37
  • 20 (a)
ManyToMany
acp-2 37
  • 20 (a)
ManyToMany
acp-3 37
  • 20 (a)
ManyToMany
acp-4 37
  • 19 (a)
ManyToMany
acp-5 37
  • 22 (a)
ManyToMany
C27A2.12 37
  • 23 (a)
ManyToMany
F26C11.1 37
  • 22 (a)
ManyToMany
pho-1 37
  • 22 (a)
ManyToMany
pho-10 37
  • 25 (a)
ManyToMany
pho-11 37
  • 23 (a)
ManyToMany
pho-12 37
  • 27 (a)
ManyToMany
pho-13 37
  • 22 (a)
ManyToMany
pho-14 37
  • 28 (a)
ManyToMany
pho-4 37
  • 22 (a)
ManyToMany
pho-5 37
  • 29 (a)
ManyToMany
T13B5.3 38
  • 33 (a)
T21B6.2 38
  • 31 (a)
F52E1.8 38
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToMany
Species with no ortholog for ACPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACPT Gene

ENSEMBL:
Gene Tree for ACPT (if available)
TreeFam:
Gene Tree for ACPT (if available)

Paralogs for ACPT Gene

Paralogs for ACPT Gene

Selected SIMAP similar genes for ACPT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACPT: view

Variants for ACPT Gene

Sequence variations from dbSNP and Humsavar for ACPT Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs266123 -- 50,794,687(-) CAGCA(C/T)CATCC intron-variant
rs266124 -- 50,793,594(-) TGAGT(C/T)CCCCC intron-variant
rs266125 -- 50,793,539(-) CAGTG(A/T)ttttt intron-variant
rs266126 -- 50,793,532(-) ttttt(G/T)ttgtt intron-variant
rs266127 -- 50,793,441(-) gcctc(C/T)cgggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACPT Gene

Variant ID Type Subtype PubMed ID
dgv3977n71 CNV Loss 21882294

Relevant External Links for ACPT Gene

HapMap Linkage Disequilibrium report
ACPT

Disorders for ACPT Gene

genes like me logo Genes that share disorders with ACPT: view

No data available for UniProtKB/Swiss-Prot for ACPT Gene

Publications for ACPT Gene

  1. Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis. (PMID: 11414767) Yousef G.M. … Diamandis E.P. (Genomics 2001) 2 3 4 23
  2. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. (PMID: 15219672) Fleisig H. … Vincent S.R. (Neuroscience 2004) 3 4 23

Products for ACPT Gene

Sources for ACPT Gene

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