ACPT Gene
protein-coding GIFtS: 52
GCID: GC19P051293
|
|
acid phosphatase, testicular
| |
Aliases
for ACPT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Acid Phosphatase, Testicular1 2 | | EC 3.1.3.23 8 | | Testicular Acid Phosphatase2 |
Export aliases for ACPT gene to outside databasesPrevious GC identifers: GC19P051922 GC19P051654 GC19P055969 GC19P055985 GC19P047628 |
Summaries
for ACPT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ACPT:
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene isup-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits alower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene hasstructural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants havebeen described, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PPAT_HUMAN, Q9BZG2Function: Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage
|
Genomic Views
for ACPT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ACPT gene promoter:
AP-4 LCR-F1 Meis-1b E47 ARP-1 STAT3 Meis-1a TGIF Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACPT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACPT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33ACPT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P051293: view genomic region
(about GC identifiers)
Start:
|
51,293,672 bp from pter |
End:
|
51,298,481 bp from pter |
Size:
|
4,810 bases |
Orientation:
|
plus strand |
|
Proteins
for ACPT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PPAT_HUMAN, Q9BZG2 (See
protein sequence)Recommended Name: Testicular acid phosphatase precursor Size: 426 amino acids; 46090 Da
Subunit: Homodimer (Probable)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: C0H3P7 Q9BZG3 Q9BZG4Alternative splicing: 3 isoforms: Q9BZG2-1 Q9BZG2-2 Q9BZG2-3 Explore the universe of human proteins at neXtProt for ACPT: NX_Q9BZG2
Post-translational modifications:
Glycosylated (Probable)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BZG2
2 DME Specific Peptides for ACPT (Q9BZG2)
ACPT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149059.1
ENSEMBL proteins: ENSP00000270593 ENSP00000270594
Human Recombinant Protein Products for ACPT:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ACPT for ontologies About GeneDecksing
ACPT Antibody Products:
Assay Products for ACPT: |
Protein
Domains /
Families
for ACPT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACPT for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BZG2ProtoNet protein and cluster: Q9BZG2 1 Blocks protein family: IPB000560 Histidine acid phosphatase
UniProtKB/Swiss-Prot: PPAT_HUMAN, Q9BZG2Similarity: Belongs to the histidine acid phosphatase family |
Function
for ACPT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PPAT_HUMAN, Q9BZG2Function: Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavageCatalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphateInduction: Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated byestrogen and progestin Enzyme Number (IUBMB): EC 3.1.3.21 2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003993 | acid phosphatase activity |
IEA | -- |
ACPT for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACPT (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACPT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ACPT (NM_033068) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACPT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACPT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACPT |
|
Pathways & Interactions
for ACPT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Riboflavin metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for ACPT):
ACPT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACPT
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ACPT (ENSP000002705934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ACPT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACPT
10/13 HMDB Compounds for ACPT (see all 13) About this table
Search CenterWatch for drugs/clinical trials and news about ACPT / PPAT
|
Transcripts
for ACPT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACPT gene (4 alternative transcripts): NM_033068.2 NM_080789.1 NM_080790.1 NM_080791.1 Unigene Cluster for ACPT: Acid phosphatase, testicular Hs.293394 [show with all ESTs]Unigene Representative Sequence: NM_0330682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000270593(uc002pta.1) ENST00000270594
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACPT (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACPT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ACPT (NM_033068) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACPT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACPT |
1 DOTS entry: DT.432968 9 AceView cDNA sequences: NM_080789 NM_080791 NM_080790 NM_033068 AA861388 AA868001 BX281038 AA861459 AA983914
GeneLoc Exon Structure
|
Expression
for ACPT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACPT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGCTCAGT
About this image
See ACPT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACPT
SOURCE GeneReport for Unigene cluster: Hs.293394
UniProtKB/Swiss-Prot: PPAT_HUMAN, Q9BZG2Tissue specificity: Expressed mainly in the testis. Also expressed in the brain where they are enriched at thepostsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain,heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression issignificantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in thetestis, trachea, prostate and bone marrow
SABiosciences Custom PCR Arrays for ACPT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACPT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACPT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACPT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACPT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACPT |
Orthologs
for ACPT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ACPT gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for ACPT (if available)
TreeFam Gene Tree for ACPT (if available) |
Paralogs
for ACPT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACPT gene
- ACPP2 ACP62 ACP22
2 SIMAP similar genes for ACPT using alignment to 1 protein entry: PPAT_HUMAN:ACPP ACP2
ACPT for paralogs About GeneDecksing
|
Genomic Variants
for ACPT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACPT (51293672 - 51298481 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACPT: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACPT |
|
Disorders
/ Diseases
for ACPT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ACPT for disorders About GeneDecksing
OMIM gene information: 606362
OMIM disorders: --
4  diseases for ACPT: About MalaCardstesticular cancer prostatitis prostate cancer alcoholism
Export disorders for ACPT gene to outside databases
|
Publications
for ACPT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACPT gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACPT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis. (PubMed id 11414767)1, 2, 3, 9 Yousef G.M.... Diamandis E.P. (2001)
- Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. (PubMed id 15219672)1, 2, 9 Fleisig H.... Vincent S.R. (2004)
|
External Searches for ACPT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ACPT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACPT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACPT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ACPT gene:
Search GeneIP for patents involving ACPT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACPT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ACPT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACPT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACPT | | | OriGene Protein Over-expression Lysate for ACPT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ACPT | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACPT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACPT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ACPT | | OriGene Custom Protein Services for ACPT | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACPT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACPT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACPT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACPT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACPT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACPT |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ACPT |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ACPT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACPT |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ACPT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACPT |
| |  | |
|
|
|
