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Aliases for ACPT Gene

Aliases for ACPT Gene

  • Acid Phosphatase, Testicular 2 3
  • EC 4 63

External Ids for ACPT Gene

Previous GeneCards Identifiers for ACPT Gene

  • GC19P051922
  • GC19P051654
  • GC19P055969
  • GC19P055985
  • GC19P051293
  • GC19P047628

Summaries for ACPT Gene

Entrez Gene Summary for ACPT Gene

  • Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACPT Gene

ACPT (Acid Phosphatase, Testicular) is a Protein Coding gene. Diseases associated with ACPT include testicular cancer and prostate cancer. Among its related pathways are Riboflavin metabolism. GO annotations related to this gene include acid phosphatase activity. An important paralog of this gene is ACPP.

UniProtKB/Swiss-Prot for ACPT Gene

  • Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACPT Gene

Genomics for ACPT Gene

Regulatory Elements for ACPT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACPT Gene

50,790,415 bp from pter
50,795,224 bp from pter
4,810 bases
Plus strand

Genomic View for ACPT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACPT Gene

Proteins for ACPT Gene

  • Protein details for ACPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testicular acid phosphatase
    Protein Accession:
    Secondary Accessions:
    • C0H3P7
    • Q9BZG3
    • Q9BZG4

    Protein attributes for ACPT Gene

    426 amino acids
    Molecular mass:
    46090 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for ACPT Gene


neXtProt entry for ACPT Gene

Proteomics data for ACPT Gene at MOPED

Selected DME Specific Peptides for ACPT Gene

Post-translational modifications for ACPT Gene

Other Protein References for ACPT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ACPT Gene

Gene Families for ACPT Gene

Protein Domains for ACPT Gene

Suggested Antigen Peptide Sequences for ACPT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the histidine acid phosphatase family.
  • Belongs to the histidine acid phosphatase family.
genes like me logo Genes that share domains with ACPT: view

Function for ACPT Gene

Molecular function for ACPT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate
UniProtKB/Swiss-Prot Function:
Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.
UniProtKB/Swiss-Prot Induction:
Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated by estrogen and progestin.

Enzyme Numbers (IUBMB) for ACPT Gene

Gene Ontology (GO) - Molecular Function for ACPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IEA --
genes like me logo Genes that share ontologies with ACPT: view

Animal Model Products

miRNA for ACPT Gene

miRTarBase miRNAs that target ACPT

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACPT

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ACPT Gene

Localization for ACPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACPT Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ACPT Gene COMPARTMENTS Subcellular localization image for ACPT gene
Compartment Confidence
chloroplast 2
endoplasmic reticulum 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ACPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ACPT: view

Pathways for ACPT Gene

SuperPathways for ACPT Gene

Superpath Contained pathways
1 Riboflavin metabolism
genes like me logo Genes that share pathways with ACPT: view

Pathways by source for ACPT Gene

1 KEGG pathway for ACPT Gene

Interacting Proteins for ACPT Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000270593 for ACPT Gene via STRING

Gene Ontology (GO) - Biological Process for ACPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with ACPT: view

Drugs for ACPT Gene

(13) HMDB Compounds for ACPT Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Butanol
  • 1-Hexanol
  • 1-Pentanol
  • Mononitrophenol
Flavin Mononucleotide
  • Flanin
genes like me logo Genes that share compounds with ACPT: view

Transcripts for ACPT Gene

mRNA/cDNA for ACPT Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACPT Gene

Acid phosphatase, testicular:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACPT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACPT Gene

No ASD Table

Relevant External Links for ACPT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACPT Gene

mRNA expression in normal human tissues for ACPT Gene

mRNA differential expression in normal tissues according to GTEx for ACPT Gene

This gene is overexpressed in Testis (26.7) and Skin - Not Sun Exposed (Suprapubic) (4.3).

SOURCE GeneReport for Unigene cluster for ACPT Gene Hs.293394

mRNA Expression by UniProt/SwissProt for ACPT Gene

Tissue specificity: Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow.
genes like me logo Genes that share expressions with ACPT: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for ACPT Gene

Orthologs for ACPT Gene

This gene was present in the common ancestor of animals.

Orthologs for ACPT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACPT 35
  • 85.49 (n)
  • 87.53 (a)
  • 86 (a)
(Canis familiaris)
Mammalia ACPT 35
  • 86.9 (n)
  • 88.31 (a)
  • 87 (a)
(Mus musculus)
Mammalia Acpt 35
  • 83.29 (n)
  • 86.15 (a)
Acpt 16
Acpt 36
  • 85 (a)
(Pan troglodytes)
Mammalia ACPT 35
  • 99.62 (n)
  • 99.44 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Acpt 35
  • 82.84 (n)
  • 84.07 (a)
(Ornithorhynchus anatinus)
Mammalia ACPT 36
  • 63 (a)
(Anolis carolinensis)
Reptilia ACPT 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494856 35
  • 59.57 (n)
  • 56.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acph-1 36
  • 28 (a)
CG6656 36
  • 27 (a)
CG9449 36
  • 28 (a)
CG9451 36
  • 26 (a)
CG9452 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea F52E1.8 37
  • 32 (a)
T13B5.3 37
  • 33 (a)
T21B6.2 37
  • 31 (a)
acp-1 36
  • 20 (a)
acp-2 36
  • 20 (a)
acp-3 36
  • 20 (a)
acp-4 36
  • 19 (a)
acp-5 36
  • 22 (a)
C27A2.12 36
  • 23 (a)
F26C11.1 36
  • 22 (a)
pho-1 36
  • 22 (a)
pho-10 36
  • 25 (a)
pho-11 36
  • 23 (a)
pho-12 36
  • 27 (a)
pho-13 36
  • 22 (a)
pho-14 36
  • 28 (a)
pho-4 36
  • 22 (a)
pho-5 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for ACPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACPT Gene

Gene Tree for ACPT (if available)
Gene Tree for ACPT (if available)

Paralogs for ACPT Gene

Paralogs for ACPT Gene

(2) SIMAP similar genes for ACPT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACPT: view

Variants for ACPT Gene

Sequence variations from dbSNP and Humsavar for ACPT Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs566755401 -- 50,795,421(+) GTAAA(-/A)AAACA downstream-variant-500B
rs566423960 -- 50,789,159(+) GAGGC(C/T)GACTG upstream-variant-2KB
rs566217084 -- 50,788,691(+) CTCAC(A/G)TGATC upstream-variant-2KB
rs566135932 -- 50,793,492(+) CCTAG(C/G)TGATG intron-variant
rs565971820 -- 50,794,638(+) AAGGG(A/G)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACPT Gene

Variant ID Type Subtype PubMed ID
dgv3977n71 CNV Loss 21882294

Relevant External Links for ACPT Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACPT Gene

Disorders for ACPT Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ACPT Gene in MalaCards »

(2) Diseases for ACPT Gene

genes like me logo Genes that share disorders with ACPT: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ACPT Gene

Publications for ACPT Gene

  1. Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis. (PMID: 11414767) Yousef G.M. … Diamandis E.P. (Genomics 2001) 2 3 4 23
  2. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. (PMID: 15219672) Fleisig H. … Vincent S.R. (Neuroscience 2004) 3 4 23

Products for ACPT Gene

Sources for ACPT Gene

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