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Aliases for ACPT Gene

Aliases for ACPT Gene

  • Acid Phosphatase, Testicular 2 3 5
  • EC 3.1.3.2 4 63
  • Testicular Acid Phosphatase 2

External Ids for ACPT Gene

Previous GeneCards Identifiers for ACPT Gene

  • GC19P051922
  • GC19P051654
  • GC19P055969
  • GC19P055985
  • GC19P051293
  • GC19P047628

Summaries for ACPT Gene

Entrez Gene Summary for ACPT Gene

  • Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACPT Gene

ACPT (Acid Phosphatase, Testicular) is a Protein Coding gene. Diseases associated with ACPT include Testicular Cancer. GO annotations related to this gene include acid phosphatase activity. An important paralog of this gene is ACPP.

UniProtKB/Swiss-Prot for ACPT Gene

  • Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACPT Gene

Genomics for ACPT Gene

Regulatory Elements for ACPT Gene

Enhancers for ACPT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACPT on UCSC Golden Path with GeneCards custom track

Genomic Location for ACPT Gene

Chromosome:
19
Start:
50,790,415 bp from pter
End:
50,795,224 bp from pter
Size:
4,810 bases
Orientation:
Plus strand

Genomic View for ACPT Gene

Genes around ACPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACPT Gene

Proteins for ACPT Gene

  • Protein details for ACPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZG2-PPAT_HUMAN
    Recommended name:
    Testicular acid phosphatase
    Protein Accession:
    Q9BZG2
    Secondary Accessions:
    • C0H3P7
    • Q9BZG3
    • Q9BZG4

    Protein attributes for ACPT Gene

    Size:
    426 amino acids
    Molecular mass:
    46090 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for ACPT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACPT Gene

Proteomics data for ACPT Gene at MOPED

Selected DME Specific Peptides for ACPT Gene

Post-translational modifications for ACPT Gene

Other Protein References for ACPT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACPT Gene

Gene Families for ACPT Gene

Protein Domains for ACPT Gene

Suggested Antigen Peptide Sequences for ACPT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZG2

UniProtKB/Swiss-Prot:

PPAT_HUMAN :
  • Belongs to the histidine acid phosphatase family.
Family:
  • Belongs to the histidine acid phosphatase family.
genes like me logo Genes that share domains with ACPT: view

Function for ACPT Gene

Molecular function for ACPT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.
UniProtKB/Swiss-Prot Function:
Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.
UniProtKB/Swiss-Prot Induction:
Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated by estrogen and progestin.

Enzyme Numbers (IUBMB) for ACPT Gene

genes like me logo Genes that share phenotypes with ACPT: view

Animal Model Products

miRNA for ACPT Gene

miRTarBase miRNAs that target ACPT

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACPT Gene

Localization for ACPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACPT Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACPT Gene COMPARTMENTS Subcellular localization image for ACPT gene
Compartment Confidence
endoplasmic reticulum 2
plasma membrane 2
chloroplast 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ACPT Gene

Pathways & Interactions for ACPT Gene

SuperPathways for ACPT Gene

No Data Available

Interacting Proteins for ACPT Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270593%0d%0a9606.ENSP00000354238%0d%0a9606.ENSP00000292180%0d%0a9606.ENSP00000350265%0d%0a
Selected Interacting proteins: ENSP00000270593 for ACPT Gene via STRING

Gene Ontology (GO) - Biological Process for ACPT Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ACPT Gene

Drugs & Compounds for ACPT Gene

(5) Drugs for ACPT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riboflavin Approved Nutra 150
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0
4-Nitrophenol Experimental Pharma 0
Flavin Mononucleotide Experimental Pharma 6

(8) Additional Compounds for ACPT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
Isopropyl alcohol
  • 2-Propanol
  • 2-Propyl alcohol
  • Alcojel
  • Alkolave
  • Avantin
67-63-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ACPT: view

Transcripts for ACPT Gene

mRNA/cDNA for ACPT Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACPT Gene

Acid phosphatase, testicular:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACPT Gene

No ASD Table

Relevant External Links for ACPT Gene

GeneLoc Exon Structure for
ACPT
ECgene alternative splicing isoforms for
ACPT

Expression for ACPT Gene

mRNA expression in normal human tissues for ACPT Gene

mRNA differential expression in normal tissues according to GTEx for ACPT Gene

This gene is overexpressed in Testis (x26.7) and Skin - Not Sun Exposed (Suprapubic) (x4.3).

SOURCE GeneReport for Unigene cluster for ACPT Gene Hs.293394

mRNA Expression by UniProt/SwissProt for ACPT Gene

Q9BZG2-PPAT_HUMAN
Tissue specificity: Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow.
genes like me logo Genes that share expression patterns with ACPT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ACPT Gene

Orthologs for ACPT Gene

This gene was present in the common ancestor of animals.

Orthologs for ACPT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACPT 35
  • 85.49 (n)
  • 87.53 (a)
ACPT 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACPT 35
  • 86.9 (n)
  • 88.31 (a)
ACPT 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acpt 35
  • 83.29 (n)
  • 86.15 (a)
Acpt 16
Acpt 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACPT 35
  • 99.62 (n)
  • 99.44 (a)
ACPT 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acpt 35
  • 82.84 (n)
  • 84.07 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ACPT 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACPT 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494856 35
  • 59.57 (n)
  • 56.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acph-1 36
  • 28 (a)
ManyToMany
CG6656 36
  • 27 (a)
ManyToMany
CG9449 36
  • 28 (a)
ManyToMany
CG9451 36
  • 26 (a)
ManyToMany
CG9452 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F52E1.8 37
  • 32 (a)
T13B5.3 37
  • 33 (a)
T21B6.2 37
  • 31 (a)
acp-1 36
  • 20 (a)
ManyToMany
acp-2 36
  • 20 (a)
ManyToMany
acp-3 36
  • 20 (a)
ManyToMany
acp-4 36
  • 19 (a)
ManyToMany
acp-5 36
  • 22 (a)
ManyToMany
C27A2.12 36
  • 23 (a)
ManyToMany
F26C11.1 36
  • 22 (a)
ManyToMany
pho-1 36
  • 22 (a)
ManyToMany
pho-10 36
  • 25 (a)
ManyToMany
pho-11 36
  • 23 (a)
ManyToMany
pho-12 36
  • 27 (a)
ManyToMany
pho-13 36
  • 22 (a)
ManyToMany
pho-14 36
  • 28 (a)
ManyToMany
pho-4 36
  • 22 (a)
ManyToMany
pho-5 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for ACPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACPT Gene

ENSEMBL:
Gene Tree for ACPT (if available)
TreeFam:
Gene Tree for ACPT (if available)

Paralogs for ACPT Gene

Paralogs for ACPT Gene

(2) SIMAP similar genes for ACPT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACPT: view

Variants for ACPT Gene

Sequence variations from dbSNP and Humsavar for ACPT Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs71355176 -- 50,795,478(+) GCAGG(C/T)ATGCC downstream-variant-500B
rs189065299 -- 50,795,370(+) GAACA(A/G)TTTCT downstream-variant-500B
rs10416096 -- 50,795,351(+) GCATA(C/T)GTGTC downstream-variant-500B
rs266122 -- 50,795,655(-) GACCA(A/G)CCTGG downstream-variant-500B
rs372052710 -- 50,795,307(+) TTTGT(A/G)TGTGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ACPT Gene

Variant ID Type Subtype PubMed ID
dgv3977n71 CNV Loss 21882294

Variation tolerance for ACPT Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.53; 88.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACPT Gene

Disorders for ACPT Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACPT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
testicular cancer
  • childhood neoplasm of the testis
- elite association - COSMIC cancer census association via MalaCards
Search ACPT in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACPT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACPT
genes like me logo Genes that share disorders with ACPT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACPT Gene

Publications for ACPT Gene

  1. Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis. (PMID: 11414767) Yousef G.M. … Diamandis E.P. (Genomics 2001) 2 3 4 23 67
  2. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. (PMID: 15219672) Fleisig H. … Vincent S.R. (Neuroscience 2004) 3 23

Products for ACPT Gene

Sources for ACPT Gene

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