ACPP Gene
protein-coding GIFtS: 68
GCID: GC03P132036
|
|
acid phosphatase, prostate
| |
Aliases
for ACPP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Acid Phosphatase, Prostate1 2 | | TMPase2 3 | | ACP-31 2 | | EC 3.1.3.23 8 | | ACP31 2 | | Ecto-5'-Nucleotidase1 | | Thiamine Monophosphatase2 3 | | Prostatic Acid Phosphatase2 | | 5'-NT2 3 | | Prostatic Acid Phosphotase2 | | 5'-Nucleotidase1 | | EC 3.1.3.53 | | PAP2 3 | | Ecto-5'-Nucleotidase1 |
Export aliases for ACPP gene to outside databasesPrevious GC identifers: GC03P128977 GC03P132781 GC03P133317 GC03P133357 GC03P133518 GC03P129415 |
Summaries
for ACPP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ACPP:
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate.It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. Analternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform containsa transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. (provided by RefSeq, Sep2008)
UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309Function: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidicconditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipidphosphatase activity and inactivates lysophosphatidic acid in seminal plasmaFunction: Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons.Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer throughdephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling
Gene Wiki entry for ACPP (Prostatic acid phosphatase)
|
Genomic Views
for ACPP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ACPP gene promoter:
ER-alpha Bach1 Sox5 HNF-3beta NF-E2 p45 Evi-1 AREB6 FOXO1a NF-E2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACPP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACPP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q22.1 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q22.1ACPP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P132036: view genomic region
(about GC identifiers)
Start:
|
132,036,211 bp from pter |
End:
|
132,087,146 bp from pter |
Size:
|
50,936 bases |
Orientation:
|
plus strand |
|
Proteins
for ACPP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309 (See
protein sequence)Recommended Name: Prostatic acid phosphatase precursor Size: 386 amino acids; 44566 Da
Subunit: Homodimer; dimer formation is required for phosphatase activity (By similarity)
Subcellular location: Isoform 1: Secreted
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-passtype I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizeswith FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane
Miscellaneous: Used as a diagnostic tool for staging metastatic prostatic cancer
6/8 PDB 3D structures from  and Proteopedia  for ACPP (see all 8):1CVI (3D)
1ND5 (3D)
1ND6 (3D)
2HPA (3D)
2L3H (3D)
2L77 (3D)
Secondary accessions: D3DNC6 Q96KY0 Q96QK9 Q96QM0Alternative splicing: 2 isoforms: P15309-1 P15309-2 Explore the universe of human proteins at neXtProt for ACPP: NX_P15309
Post-translational modifications:
N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated withpartially sialylated triantennary complex oligosaccharides1
Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloidbeta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to targetcells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), aconstituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Alsosimilarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P15309
4/5 DME Specific Peptides for ACPP (P15309) (see all 5)
ACPP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001090.2 NP_001127666.1
ENSEMBL proteins: ENSP00000337471 ENSP00000418366 ENSP00000417744 ENSP00000323036 ENSP00000422036
Human Recombinant Protein Products for ACPP:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
ACPP for ontologies About GeneDecksing
ACPP Antibody Products:
Assay Products for ACPP: |
Protein
Domains /
Families
for ACPP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACPP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P15309ProtoNet protein and cluster: P15309 1 Blocks protein family: IPB000560 Histidine acid phosphatase
UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309Similarity: Belongs to the histidine acid phosphatase family |
Function
for ACPP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PPAP_HUMAN, P15309Function: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidicconditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipidphosphatase activity and inactivates lysophosphatidic acid in seminal plasmaFunction: Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons.Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer throughdephosphorylation of ERBB2 and deactivation of MAPK-mediated signalingCatalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphateCatalytic activity: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphateEnzyme regulation: Phosphatase activity inhibited by L(+)-tartrate, and by its derivative,alpha-benzylaminobenzylphosphonic acid Genatlas biochemistry entry for ACPP:phosphatase acid,prostate
Enzyme Numbers (IUBMB): EC 3.1.3.21 2 EC 3.1.3.51
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ACPP for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for ACPP:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Acpp):
ACPP for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACPP (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACPP (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ACPP (NM_001134194) | |  | Sino Biological Human cDNA Clone for ACPP | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACPP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACPP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACPP |
|
Pathways & Interactions
for ACPP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | ATP/ITP metabolism | | | 2 | Riboflavin metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for ACPP
1  GeneGo (Thomson Reuters) Pathway for ACPP
1 
Kegg Pathway (Kegg details for ACPP):
ACPP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACPP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/11 Interacting proteins for ACPP (P153091, 2, 3 ENSP000003230364) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006144 | purine nucleobase metabolic process |
IEA | -- | | GO:0009117 | nucleotide metabolic process |
IEA | -- | | GO:0016311 | dephosphorylation |
-- | -- | | GO:0046085 | adenosine metabolic process |
IEA | -- |
ACPP for ontologies About GeneDecksing
|
Drugs & Compounds
for ACPP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ACPP for compounds About GeneDecksing
 Browse Tocris compounds for ACPP
6 HMDB Compounds for ACPP About this table
3 DrugBank Compounds for ACPP About this table
10/65 Novoseek chemical compound relationships for ACPP gene (see all 65) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| provenge |
91.2 |
16 |
10873066 (2), 11099318 (2), 16736512 (2), 17696825 (1) (see all 9) |
| estracyt |
68.3 |
4 |
1715080 (1), 7840515 (1) |
| nilutamide |
65.5 |
6 |
8259343 (2), 7678043 (1), 1992599 (1) |
| testosterone |
64 |
108 |
7510912 (7), 1373297 (4), 11280747 (2), 8138434 (2) (see all 46) |
| dihydrotestosterone |
62.2 |
31 |
12362977 (3), 8653325 (3), 8827085 (2), 9506725 (2) (see all 8) |
| phenylphosphate |
61 |
3 |
11513970 (1), 15082403 (1) |
| fmpp |
60.2 |
2 |
7592741 (1) |
| estramustine phosphate |
57.4 |
5 |
7542158 (2), 7526970 (1), 8653325 (1) |
| mians |
55.5 |
2 |
17520089 (1), 12719131 (1) |
| phosphotyrosine |
54 |
9 |
7490893 (2), 8248785 (1), 11513970 (1), 8166732 (1) (see all 7) |
Search CenterWatch for drugs/clinical trials and news about ACPP / PPAP
|
Transcripts
for ACPP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACPP gene (2 alternative transcripts): NM_001099.4 NM_001134194.1 Unigene Cluster for ACPP: Acid phosphatase, prostate Hs.433060 [show with all ESTs]Unigene Representative Sequence: NM_0010999 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000336375(uc010htp.2 uc003eon.3) ENST00000495911 ENST00000475741
ENST00000351273(uc003eop.4) ENST00000493235 ENST00000489084 ENST00000483689
ENST00000512463 ENST00000507647
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACPP (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACPP (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ACPP (NM_001134194) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACPP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACPP |
Additional cDNA sequence: AB102888.1 AK300540.1 BC007460.1 BC008493.1 BC016344.1 BC017877.1 M24902.1 M34840.1 X52174.1 X53605.1 24/27 DOTS entries (see all 27): DT.80101926 DT.91984927 DT.433646 DT.87004158 DT.100817219 DT.120900128 DT.91937774 DT.100817218 DT.91722686 DT.420131 DT.91761053 DT.120900097 DT.433260 DT.91647907 DT.65288114 DT.91852927 DT.95091096 DT.100780538 DT.120900095 DT.120900105 DT.120900108 DT.120900148 DT.91761070 DT.97783982 24/449 AceView cDNA sequences (see all 449): BQ101187 BF063890 BF476050 AI547266 BF060817 AA371462 AI670092 BF438310 BM693355 BF476609 AI685444 BF000933 AI401663 BQ000968 BE856038 BF060849 BM773350 BQ924880 BF475839 AA371312 BM772607 BQ934114 BX113133 CB989650
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ACPP (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ACPP
|
Expression
for ACPP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACPP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTAGAGAAC
About this image
See ACPP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACPP
SOURCE GeneReport for Unigene cluster: Hs.433060
UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309Tissue specificity: Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Alsoexpressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreaticislet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures.Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostatecancer
SABiosciences Custom PCR Arrays for ACPP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACPP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACPP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACPP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACPP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACPP |
Orthologs
for ACPP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ACPP gene from 4/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ACPP1 |
acid phosphatase, prostate |
59.8(n)
54.17(a) |
|
776390 XM_001235913.1 XP_001235914.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ACPP6 |
-- |
53(a) |
1 ↔ 1 |
6(37948131-37968777) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Acph-13 |
acid phosphatase |
37(a)
(best of 5) |
|
3 99D1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
T13B5.33 |
acid phosphatase |
32(a)
(best of 5) |
|
II(1097327-1099531) -- |
ENSEMBL Gene Tree for ACPP (if available)
TreeFam Gene Tree for ACPP (if available) |
Paralogs
for ACPP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACPP gene
- ACP62 ACPT2 ACP22
2 SIMAP similar genes for ACPP using alignment to 6 protein entries: PPAP_HUMAN (see all proteins):ACP2 ACPT
ACPP for paralogs About GeneDecksing
|
Genomic Variants
for ACPP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACPP (132036211 - 132087146 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACPP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACPP |
|
Disorders
/ Diseases
for ACPP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ACPP for disorders About GeneDecksing
OMIM gene information: 171790
OMIM disorders: --
20/68  diseases for ACPP (see all 68): About MalaCardsprostatitis lymphoepithelioma-like carcinoma chediak-higashi syndrome root resorption
endodermal sinus tumor sphenoid sinusitis nephrogenic adenoma nephrogenic adenoma of the urethra
transitional cell carcinoma cloacogenic carcinoma urethra cancer b-cell lymphomas
varicocele prostate transitional cell carcinoma adenomatoid tumor clear cell adenocarcinoma
giant cell tumor adenoma histoplasmosis sinusitis
4 diseases from the University of Copenhagen DISEASES database for ACPP:Prostate cancer Prostatic hypertrophy Carcinoma Prostatitis 10/66 Novoseek disease relationships for ACPP gene (see all 66) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prostate carcinoma |
89 |
103 |
7683340 (3), 1965432 (2), 7691762 (2), 7649350 (2) (see all 58) |
| prostate cancer |
87 |
264 |
7602779 (5), 8564745 (4), 11351352 (4), 1380223 (4) (see all 99) |
| prostatic adenocarcinoma |
83.5 |
37 |
7525979 (5), 1699237 (2), 7514089 (2), 8958315 (1) (see all 20) |
| benign prostatic hyperplasia |
77.9 |
38 |
1723815 (2), 1385128 (2), 1700860 (1), 1701586 (1) (see all 24) |
| lysosomal acid phosphatase |
75.4 |
1 |
1720287 (1) |
| prostate cancer stage d |
71.7 |
1 |
17991541 (1) |
| prostatic diseases |
69.3 |
9 |
1721770 (2), 1693867 (1), 15623486 (1), 1280403 (1) (see all 6) |
| adenocarcinoma |
68.7 |
54 |
7840515 (3), 11888088 (2), 10738193 (2), 15379952 (2) (see all 29) |
| bone metastases |
63.2 |
15 |
7602779 (1), 11141722 (1), 1518166 (1), 8291878 (1) (see all 12) |
| adenocarcinoma clear cell |
61.7 |
5 |
7536368 (2), 9865832 (1), 7645457 (1) |
Human Genome Epidemiology (HuGE) Navigator: ACPP (1 document)
Export disorders for ACPP gene to outside databases
|
Publications
for ACPP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACPP gene, integrated from 9 sources (see all 563):
(articles sorted by number of sources associating them with ACPP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. (PubMed id 9804805)1, 2, 9 Lacount M.W.... Lebioda L. (1998)
- Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer. (PubMed id 19403677)1, 2, 9 Hong S....Silverman R.H. (2009)
- Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. (PubMed id 15280042)1, 2, 9 Tanaka M....Arai H. (2004)
- Prostatic acid phosphatase expression in human tissues. (PubMed id 21487525)1, 2 Graddis T.J.... Trager J.B. (2011)
- Human prostatic acid phosphatase, an authentic tyrosi ne phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell grow th. (PubMed id 20498373)1, 2 Chuang T.D....Lin M.F. (2010)
- Semen-derived amyloid fibrils drastically enhance HIV infection. (PubMed id 18083097)1, 2 Munch J....Kirchhoff F. (2007)
- Prostatic acid phosphatase is not a prostate specific target. (PubMed id 17638863)1, 2 Quintero I.B....Vihko P.T. (2007)
- Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design. (PubMed id 12525165)1, 2 Ortlund E....Lebioda L. (2003)
- Crystal structure of human prostatic acid phosphatase . (PubMed id 10639192)1, 2 Jakob C.G....Lebioda L. (2000)
- Nucleotide sequence of human prostatic acid phosphatase ACPP gene, including seven Alu repeats. (PubMed id 7951074)1, 2 Sharief F.S. and Li S.S.-L. (1994)
|
External Searches for ACPP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ACPP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACPP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACPP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ACPP gene:
Search GeneIP for patents involving ACPP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACPP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ACPP | | OriGene shRNA RFP for ACPP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACPP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACPP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ACPP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACPP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACPP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ACPP | | OriGene Custom Protein Services for ACPP | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACPP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACPP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACPP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACPP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACPP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACPP |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ACPP |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ACPP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACPP |
|  |  |  |  | | | | ThermoFisher Antibodies for ACPP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACPP |
| |  | |
|
|
|
