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Aliases & Descriptions for ACPP
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ACP-3 1 , 2 ACP3 1 , 2 EC 3.1.3.2 3 PAP 2
Descriptions acid phosphatase, prostate 2 prostatic acid phosphotase 2
Search outside databases for aliases for ACPP genePrevious GC identifers: GC03P128977 GC03P132781 GC03P133317 GC03P133357
Summaries for ACPP (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ACPP : This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcoholand orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelialcells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoformhas been found for this gene. This isoform contains a transmembrane domain and is localized in theplasma membrane-endosomal-lysosomal pathway. [provided by RefSeq] Gene Wiki entry for ACPP (Prostatic_acid_phosphatase)
Genomic Location for ACPP
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ACPP gene Entrez Gene cytogenetic band: 3q21-q23 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q21-qter ACPP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P133518:
(about GC identifiers )
Start:
133,518,941 bp from pter
End:
133,569,831 bp from pter
Size:
50,891 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000003.10 NT_005612.15 Proteins for ACPP
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309 (See
protein sequence )Recommended Name: Prostatic acid phosphatase precursor Size : 386 amino acids; 44566 Da
Subunit : Homodimer
Subcellular location : Isoform 1: Secreted (By similarity)
Subcellular location : Isoform 2: Lysosome membrane; Single-pass type I membrane protein (Bysimilarity). Note=Predominantly localized in the plasma membrane but also detected inintracellular vesicles (By similarity)
PDB structures from and Proteopedia : 1CVI (3D)
 1ND5 (3D)
 1ND6 (3D)
 2HPA (3D)
 
Secondary accessions : Q96KY0 Q96QK9 Q96QM0Alternative splicing : 2 isoforms : P15309-1 P15309-2
REFSEQ proteins (2 alternative transcripts):
NP_001090.2 NP_001127666.1 ENSEMBL proteins: ENSP00000323036 ENSP00000337471 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ACPP: Assays for ACPP:
Protein
Domains/ Families for ACPP(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P15309 ProtoNet protein and cluster: P15309
1 Blocks protein family : IPB000560 Histidine acid phosphatase UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309 Similarity : Belongs to the histidine acid phosphatase family
Gene Function for ACPP
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001134194 Applied Biosystems Silencer ® siRNAs for ACPP Sigma-Aldrich siRNA and siRNA Panels for ACPP Sigma-Aldrich shRNA Panels and shRNA for ACPP Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001099                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001099                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001099  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001134194 UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309 Catalytic activity : A phosphate monoester + H(2)O = an alcohol + phosphateEnzyme Number (IUBMB): EC 3.1.3.2
Genatlas biochemistry entry for ACPP :phosphatase acid,prostate 2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003993 acid phosphatase activity
IEA -- GO:0016787 hydrolase activity
IEA --
About this table
Pathways & Interactions for ACPP
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ACPP (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for ACPP 5/21 Interacting proteins for ACPP (ENSP00000323036 3 ) via UniProtKB, MINT, and/or STRING (see all 21
)About this table
Drugs & Compounds for ACPP (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ACPP 10/29 Novoseek chemical compound relationships for ACPP gene (see all 29
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
provenge
91.53
16
10873066 (2), 11099318 (2), 16736512 (2), 17696825 (1) (see all 9 )
phenylphosphate
62.10
3
11513970 (1), 15082403 (1)
fmpp
60.16
2
7592741 (1)
mians
55.89
2
17520089 (1), 12719131 (1)
phosphotyrosine
53.28
8
7490893 (2), 8248785 (1), 11513970 (1), 8166732 (1) (see all 6 )
17-hydroxypregnenolone
33.53
3
8664166 (1), 8259343 (1)
hematoxylin
28.15
6
7520585 (1), 7490838 (1), 7591889 (1), 8348500 (1)
neopterin
22.97
4
1697204 (1), 2180721 (1), 2029401 (1)
androstenedione
15.88
4
8664166 (1), 8259343 (1), 9506725 (1)
tyrosine
15.38
12
8806615 (2), 12712404 (2), 11586265 (1), 12832290 (1) (see all 8 )
About this table
Transcripts for ACPP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001134194 Sigma-Aldrich siRNA and siRNA Panels for ACPP Sigma-Aldrich shRNA Panels and shRNA for ACPP Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001099 NM_001134194
REFSEQ mRNAs for ACPP gene (2 alternative transcripts): NM_001099.4 NM_001134194.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001099 NM_001134194
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001099                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001099                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001099  
Additional cDNA sequence: AB102888.1 AK300540.1 BC007460.1 BC008493.1 BC016344.1 BC017877.1 M24902.1 M34840.1 X52174.1 X53605.1
24/25 DOTS entries (see all 25
): DT.80101926 DT.91984927 DT.433646 DT.87004158 DT.100817219 DT.91937774 DT.100817218 DT.120900128 DT.91722686 DT.420131 DT.91761053 DT.100780538 DT.120900097 DT.433260 DT.91647907 DT.65288114 DT.91852927 DT.120900095 DT.120900105 DT.120900108 DT.120900148 DT.91761070 DT.97783982 DT.120900101
24/449 AceView cDNA sequences (see all 449
):AA371312 AI401663 BQ101187 BM773350 BF475839 AA371462 BQ000968 BF476050 BF589624 AI597835 BF438310 BQ934114 BX113133 BF000933 AI685444 AI547266 BM693355 CB989650 BM773214 BQ924880 AA502799 BF476609 BM772607 BE856038
highest scoring ESTs for ACPP :AI659898 M24902 AA224876 AA228288 AA370186 AA492280 AA502798 AA502799 AA502979 AA503261
Unigene Cluster for ACPP: Acid phosphatase, prostate Hs.433060 [show with all ESTs ] Unigene Representative Sequence: NM_001099 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ACPP (see all 6
) ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 SP1 :             -   -                 -   -     SP2 :             -   -                       SP3 :             -   -   -                     SP4 :                                     SP5 :         -     -   -                      
About this scheme ECgene alternative splicing isoforms for ACPP 2 Ensembl transcripts including schematic representations : ENST00000351273
ENST00000336375
Expression for ACPP
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ACPP expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ACPP 1 / 2 / 3
8 probe-sets matching ACPP gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCTAGAGAACSOURCE GeneReport for Unigene cluster: Hs.433060 Expression variation in blood from EXPOLDB for ACPP
Orthologs for ACPP
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ACPP gene from 5/9 species (see all 9
)
About this table Species with no ortholog for ACPP ENSEMBL Gene Tree for ACPP Paralogs for ACPP (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ACPP gene ACP6 2 ACPT 2 ACP2 2
SNPs/Variants for ACPP (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ACPP (up to first 250kb)
Disorders & Mutations for ACPP
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 171790 10/65 Novoseek disease relationships for ACPP gene (see all 65
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
prostate carcinoma
89.18
103
7683340 (3), 1965432 (2), 7691762 (2), 7649350 (2) (see all 58 )
prostate cancer
87.16
259
7602779 (5), 8564745 (4), 11351352 (4), 1380223 (4) (see all 99 )
prostatic adenocarcinoma
83.64
36
7525979 (5), 1699237 (2), 7514089 (2), 8958315 (1) (see all 19 )
benign prostatic hyperplasia
78.05
38
1723815 (2), 1385128 (2), 1700860 (1), 1701586 (1) (see all 24 )
lysosomal acid phosphatase
75.80
1
1720287 (1)
prostate cancer stage d
72.52
1
17991541 (1)
adenocarcinoma
68.63
53
7840515 (3), 11888088 (2), 10738193 (2), 15379952 (2) (see all 28 )
prostatic diseases
68.51
9
1721770 (2), 1693867 (1), 15623486 (1), 1280403 (1) (see all 6 )
bone metastases
64.42
15
7602779 (1), 11141722 (1), 1518166 (1), 8291878 (1) (see all 12 )
adenocarcinoma clear cell
62.61
5
7536368 (2), 9865832 (1), 7645457 (1)
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Medical News for ACPP (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ACPP (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/494 PubMed articles for ACPP gene (see all 494
): Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. (PubMed id 9804805) 1, 3, 4 Lacount M.W.... Lebioda L. (1998) Nucleotide sequence of human prostatic acid phosphatase ACPP gene, including seven Alu repeats. (PubMed id 7951074) 3, 4 Sharief F.S. and Li S.S.-L. (1994) Structure of human prostatic acid phosphatase gene. (PubMed id 1375464) 3, 4 Sharief F.S. and Li S.S.-L. (1992) Covalent structure, disulfide bonding, and identification of reactive surface and active site residues of human prostatic acid phosphatase. (PubMed id 1989985) 3, 4 van Etten R.L.... Moore D.L. (1991) Nucleotide sequence of human prostatic acid phosphatase determined from a full-length cDNA clone. (PubMed id 2395659) 3, 4 Tailor P.G.... Patel P.C. (1990) Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase. (PubMed id 2712834) 3, 4 Sharief F.S.... Li S.S.-L. (1989) Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase. (PubMed id 2842184) 3, 4 Vihko P.... Huhtala M.L. (1988) Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates. (PubMed id 11784334) 1, 3 Brillard-Bourdet M....Gauthier F. (2002) Prostatic acid phosphatase in breast cyst fluid. (PubMed id 19108401) 1, 3 Erbas H....Irfanoglu M.E. (2007) Comparative analysis of prostatic acid phosphatase and prostate-specific antigen mRNA levels in hyperplastic prostate stimulated with steroid hormones and growth factors. (PubMed id 12362977) 1, 3 Dulinska J....Labedz M. (2002)
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Genome Databases showing ACPP
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ACPP
(According to HUGE )
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Specialized Databases showing ACPP (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ACPP (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ACPP:
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