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Aliases for ACPP Gene

Aliases for ACPP Gene

  • Acid Phosphatase, Prostate 2 3 5
  • Prostatic Acid Phosphatase 2 3
  • Thiamine Monophosphatase 3 4
  • Ecto-5-Nucleotidase 3 4
  • EC 3.1.3.2 4 58
  • TMPase 3 4
  • 5-NT 3 4
  • Prostatic Acid Phosphotase 3
  • 5-Nucleotidase 4
  • EC 3.1.3.5 4
  • ACP-3 3
  • ACP3 3
  • PAP 4

External Ids for ACPP Gene

Previous GeneCards Identifiers for ACPP Gene

  • GC03P128977
  • GC03P132781
  • GC03P133317
  • GC03P133357
  • GC03P133518
  • GC03P132036
  • GC03P129415

Summaries for ACPP Gene

Entrez Gene Summary for ACPP Gene

  • This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

GeneCards Summary for ACPP Gene

ACPP (Acid Phosphatase, Prostate) is a Protein Coding gene. Diseases associated with ACPP include Prostate Cancer and Nephrogenic Adenoma Of The Urethra. Among its related pathways are Pyrimidine metabolism (KEGG) and Innate Immune System. GO annotations related to this gene include protein homodimerization activity and phosphatase activity. An important paralog of this gene is ACP2.

UniProtKB/Swiss-Prot for ACPP Gene

  • A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

  • Isoform 2: the cellular form also has ecto-5-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Gene Wiki entry for ACPP Gene

Additional gene information for ACPP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACPP Gene

Genomics for ACPP Gene

Regulatory Elements for ACPP Gene

Enhancers for ACPP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H132290 0.8 Ensembl ENCODE 16.2 -26.5 -26466 0 ZFHX2 POLR2A CEBPB MAX MYC ACPP CPNE4
GH03H132342 0.7 Ensembl 13 +25.7 25711 0 CTCF ZNF654 TRIM22 CEBPB REST RAD21 RFX5 ZNF316 SMC3 ZNF143 ACPP GC03P132328 LOC100130550
GH03H132282 1 Ensembl ENCODE 4.5 -32.6 -32634 3 CTCF HINFP MAX GATA2 POLR2A HNF4G STAT1 ZNF740 CEBPB USF2 CPNE4 ACPP RPL7P16
GH03H132346 0.9 Ensembl ENCODE 4.6 +29.7 29740 1 SOX5 SOX13 FOXA2 RFX1 DPF2 FOXA1 CTBP1 GATA3 FOXP1 ACPP GC03P132328 LOC100130550
GH03H132289 0.2 ENCODE 16.3 -27.7 -27702 1 ACPP CPNE4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACPP on UCSC Golden Path with GeneCards custom track

Promoters for ACPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158498 333 201 PKNOX1 NFIB SIN3A FEZF1 ZNF2 RCOR1 CEBPB REST ZNF843 ZNF217

Genomic Location for ACPP Gene

Chromosome:
3
Start:
132,317,367 bp from pter
End:
132,368,302 bp from pter
Size:
50,936 bases
Orientation:
Plus strand

Genomic View for ACPP Gene

Genes around ACPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACPP Gene

Proteins for ACPP Gene

  • Protein details for ACPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15309-PPAP_HUMAN
    Recommended name:
    Prostatic acid phosphatase
    Protein Accession:
    P15309
    Secondary Accessions:
    • D3DNC6
    • Q5FBY0
    • Q96KY0
    • Q96QK9
    • Q96QM0

    Protein attributes for ACPP Gene

    Size:
    386 amino acids
    Molecular mass:
    44566 Da
    Quaternary structure:
    • Homodimer; dimer formation is required for phosphatase activity.
    Miscellaneous:
    • Used as a diagnostic tool for staging metastatic prostatic cancer.

    Three dimensional structures from OCA and Proteopedia for ACPP Gene

    Alternative splice isoforms for ACPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACPP Gene

Selected DME Specific Peptides for ACPP Gene

P15309:
  • WPQGFGQLT
  • DRTLMSA
  • DTTVSGLQMAL
  • WQPIPVHT
  • RLQGGVL

Post-translational modifications for ACPP Gene

  • N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
  • Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
  • Glycosylation at Asn94, posLast=220220, and Asn333
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ACPP (Prostatic Acid Phosphatase/ACPP)
  • Cell Signaling Technology (CST) Antibodies for ACPP (ACPP)

Protein Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for ACPP

Domains & Families for ACPP Gene

Gene Families for ACPP Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ACPP Gene

Graphical View of Domain Structure for InterPro Entry

P15309

UniProtKB/Swiss-Prot:

PPAP_HUMAN :
  • Belongs to the histidine acid phosphatase family.
Family:
  • Belongs to the histidine acid phosphatase family.
genes like me logo Genes that share domains with ACPP: view

Function for ACPP Gene

Molecular function for ACPP Gene

GENATLAS Biochemistry:
phosphatase acid,prostate
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphatase activity inhibited by L(+)-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.
UniProtKB/Swiss-Prot Function:
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
UniProtKB/Swiss-Prot Function:
Isoform 2: the cellular form also has ecto-5-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Enzyme Numbers (IUBMB) for ACPP Gene

Gene Ontology (GO) - Molecular Function for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IMP 8132635
GO:0005515 protein binding IPI 9705354
GO:0008253 5-nucleotidase activity IDA,IEA 18940592
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IMP 18940592
genes like me logo Genes that share ontologies with ACPP: view
genes like me logo Genes that share phenotypes with ACPP: view

Animal Models for ACPP Gene

MGI Knock Outs for ACPP:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACPP

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ACPP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACPP Gene

Localization for ACPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACPP Gene

Isoform 1: Secreted.
Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). {ECO:0000269 PubMed:17638863, ECO:0000269 PubMed:17897319}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACPP gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
lysosome 5
cytosol 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IMP 22389722
GO:0005622 intracellular IDA 17658863
GO:0005634 nucleus IDA 21630459
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with ACPP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACPP Gene

Pathways & Interactions for ACPP Gene

genes like me logo Genes that share pathways with ACPP: view

Pathways by source for ACPP Gene

3 Reactome pathways for ACPP Gene
1 GeneGo (Thomson Reuters) pathway for ACPP Gene

Gene Ontology (GO) - Biological Process for ACPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0006772 thiamine metabolic process IEA,ISS --
GO:0009117 nucleotide metabolic process IEA --
GO:0016311 dephosphorylation IMP 8132635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ACPP: view

No data available for SIGNOR curated interactions for ACPP Gene

Drugs & Compounds for ACPP Gene

(46) Drugs for ACPP Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sipuleucel-T Approved Pharma Target, antagonist, inhibitory immune response 0
Phosphoric acid Approved Pharma 0
Tartaric acid Approved Pharma 0
Water Approved Pharma 0
Riboflavin Approved, Vet_approved Nutra 186

(31) Additional Compounds for ACPP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ACPP: view

Transcripts for ACPP Gene

Unigene Clusters for ACPP Gene

Acid phosphatase, prostate:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ACPP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ACPP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - - -
SP6:

Relevant External Links for ACPP Gene

GeneLoc Exon Structure for
ACPP
ECgene alternative splicing isoforms for
ACPP

Expression for ACPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACPP Gene

This gene is overexpressed in Prostate (x47.6).

Protein differential expression in normal tissues from HIPED for ACPP Gene

This gene is overexpressed in Urine (28.4), Prostate (20.6), and Seminal vesicle (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACPP Gene



NURSA nuclear receptor signaling pathways regulating expression of ACPP Gene:

ACPP

SOURCE GeneReport for Unigene cluster for ACPP Gene:

Hs.433060

mRNA Expression by UniProt/SwissProt for ACPP Gene:

P15309-PPAP_HUMAN
Tissue specificity: Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.

Evidence on tissue expression from TISSUES for ACPP Gene

  • Kidney(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ACPP: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACPP Gene

Orthologs for ACPP Gene

This gene was present in the common ancestor of animals.

Orthologs for ACPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACPP 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia ACPP 33 34
  • 85.07 (n)
dog
(Canis familiaris)
Mammalia ACPP 33 34
  • 84.61 (n)
mouse
(Mus musculus)
Mammalia Acpp 33 16 34
  • 82.86 (n)
rat
(Rattus norvegicus)
Mammalia Acpp 33
  • 82 (n)
oppossum
(Monodelphis domestica)
Mammalia ACPP 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACPP 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACPP 33 34
  • 61.21 (n)
lizard
(Anolis carolinensis)
Reptilia ACPP 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acpp 33
  • 58.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta Acph-1 35 34
  • 37 (a)
CG9449 35 34
  • 36 (a)
CG9452 35 34
  • 33 (a)
CG9451 35 34
  • 32 (a)
CG6656 35 34
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea pho-6 33
  • 43.24 (n)
F52E1.8 35
  • 32 (a)
T13B5.3 35
  • 32 (a)
pho-1 35 34
  • 31 (a)
T21B6.2 35
  • 31 (a)
pho-14 34
  • 30 (a)
ManyToMany
R13H4.3 35
  • 29 (a)
pho-5 34
  • 28 (a)
ManyToMany
pho-10 34
  • 25 (a)
ManyToMany
pho-12 34
  • 25 (a)
ManyToMany
F26C11.1 34
  • 24 (a)
ManyToMany
C27A2.12 34
  • 23 (a)
ManyToMany
pho-11 34
  • 23 (a)
ManyToMany
pho-13 34
  • 22 (a)
ManyToMany
pho-4 34
  • 22 (a)
ManyToMany
acp-1 34
  • 21 (a)
ManyToMany
acp-3 34
  • 21 (a)
ManyToMany
acp-5 34
  • 21 (a)
ManyToMany
acp-2 34
  • 20 (a)
ManyToMany
acp-4 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11668 33
Species where no ortholog for ACPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACPP Gene

ENSEMBL:
Gene Tree for ACPP (if available)
TreeFam:
Gene Tree for ACPP (if available)

Paralogs for ACPP Gene

Paralogs for ACPP Gene

(2) SIMAP similar genes for ACPP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ACPP: view

Variants for ACPP Gene

Sequence variations from dbSNP and Humsavar for ACPP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs864309497 Uncertain significance 132,349,986(+) AAAAC(-/TCA)TCATG cds-indel
rs1000006397 -- 132,348,241(+) ACGAA(G/T)ATTTA intron-variant
rs1000084793 -- 132,347,190(+) GAAAC(C/T)AGCTG intron-variant
rs1000124506 -- 132,361,432(+) ATAAC(A/G)CTGAC intron-variant
rs1000144114 -- 132,357,053(+) CCTGC(C/T)CCCAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACPP Gene

Variant ID Type Subtype PubMed ID
esv2762346 CNV loss 21179565
esv3597825 CNV loss 21293372
nsv478509 CNV novel sequence insertion 20440878
nsv508245 CNV deletion 20534489
nsv829728 CNV gain 17160897

Variation tolerance for ACPP Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACPP Gene

Disorders for ACPP Gene

MalaCards: The human disease database

(5) MalaCards diseases for ACPP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
nephrogenic adenoma of the urethra
  • nephrogenic adenoma of urethra
lysosomal acid phosphatase deficiency
  • acid phosphatase deficiency
phyllode tumor
  • cystosarcoma phyllode
bladder neck obstruction
  • obstruction of bladder neck or vesicourethral orifice
- elite association - COSMIC cancer census association via MalaCards
Search ACPP in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACPP

Genetic Association Database (GAD)
ACPP
Human Genome Epidemiology (HuGE) Navigator
ACPP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACPP
genes like me logo Genes that share disorders with ACPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACPP Gene

Publications for ACPP Gene

  1. Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. (PMID: 9804805) LaCount MW … Lebioda L (The Journal of biological chemistry 1998) 3 4 22 60
  2. Structure of human prostatic acid phosphatase gene. (PMID: 1375464) Sharief FS … Li SS (Biochemical and biophysical research communications 1992) 2 3 4 60
  3. Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase. (PMID: 2842184) Vihko P … Huhtala ML (FEBS letters 1988) 2 3 4 60
  4. Prostatic acid phosphatase expression in human tissues. (PMID: 21487525) Graddis TJ … Trager JB (International journal of clinical and experimental pathology 2011) 3 4 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for ACPP Gene

Sources for ACPP Gene

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