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ACPP Gene

protein-coding   GIFtS: 71
GCID: GC03P132036

Acid Phosphatase, Prostate

  See ACPP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acid Phosphatase, Prostate1 2     ACP-32
Thiamine Monophosphatase2 3     ACP32
5'-NT2 3     ecto-5'-nucleotidase2
5'-nucleotidase2 3     Prostatic Acid Phosphatase2
PAP2 3     Prostatic Acid Phosphotase2
TMPase2 3     EC 3.1.3.53
EC 3.1.3.23 8     Ecto-5'-nucleotidase3

External Ids:    HGNC: 1251   Entrez Gene: 552   Ensembl: ENSG000000142577   OMIM: 1717905   UniProtKB: P153093   

Export aliases for ACPP gene to outside databases

Previous GC identifers: GC03P128977 GC03P132781 GC03P133317 GC03P133357 GC03P133518 GC03P129415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACPP Gene:
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and
orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the
prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this
gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal
pathway. (provided by RefSeq, Sep 2008)

GeneCards Summary for ACPP Gene:
ACPP (acid phosphatase, prostate) is a protein-coding gene. Diseases associated with ACPP include prostatic hypertrophy, and nephrogenic adenoma of the urethra. GO annotations related to this gene include protein homodimerization activity and acid phosphatase activity. An important paralog of this gene is ACP6.

UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309
Function: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic
conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has
lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma
Function: Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG)
neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate
cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling

Gene Wiki entry for ACPP (Prostatic acid phosphatase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACPP gene promoter:
         ER-alpha   Bach1   Sox5   HNF-3beta   NF-E2 p45   Evi-1   AREB6   FOXO1a   NF-E2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ACPP promoter sequence
   Search Chromatin IP Primers for ACPP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

ACPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACPP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P132036:  view genomic region     (about GC identifiers)

Start:
132,036,211 bp from pter      End:
132,087,146 bp from pter
Size:
50,936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309 (See protein sequence)
Recommended Name: Prostatic acid phosphatase precursor  
Size: 386 amino acids; 44566 Da
Subunit: Homodimer; dimer formation is required for phosphatase activity (By similarity)
Miscellaneous: Used as a diagnostic tool for staging metastatic prostatic cancer
Selected PDB 3D structures from and Proteopedia for ACPP (see all 8):
1CVI (3D)        1ND5 (3D)        1ND6 (3D)        2HPA (3D)        2L3H (3D)        2L77 (3D)    
Secondary accessions: D3DNC6 Q5FBY0 Q96KY0 Q96QK9 Q96QM0
Alternative splicing: 3 isoforms:  P15309-1   P15309-2   P15309-3   

Explore the universe of human proteins at neXtProt for ACPP: NX_P15309

Explore proteomics data for ACPP at MOPED

Post-translational modifications: 

  • N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated
    with partially sialylated triantennary complex oligosaccharides1
  • Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms
    amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach
    them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol
    epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV
    infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus)
    infection1
  • Glycosylation2 at Asn94, Asn220, Asn333
  • Selected DME Specific Peptides for ACPP (P15309) (see all 5)
     RLQGGVL  DRTLMSA  WQPIPVHT  WPQGFGQLT 


    See ACPP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001090.2  NP_001127666.1  

    ENSEMBL proteins: 
     ENSP00000337471   ENSP00000418366   ENSP00000417744   ENSP00000323036   ENSP00000422036  

    ACPP Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ACPP Protein
    R&D Systems Recombinant & Natural Proteins for ACPP (Prostatic Acid Phosphatase/ACPP)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACPP
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ACPP
    GenScript Custom Purified and Recombinant Proteins Services for ACPP
    Novus Biologicals ACPP Proteins
    Novus Biologicals ACPP Lysate
    Sino Biological Recombinant Protein for ACPP
    Sino Biological Cell Lysate for ACPP
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ACPP 

    ACPP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ACPP (Prostatic Acid Phosphatase/ACPP)
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    Novus Biologicals ACPP Antibodies
    Abcam antibodies for ACPP
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ACPP
    LSBio Antibodies in human, mouse, rat for ACPP

    ACPP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ACPP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ACPP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000560 His_Pase_superF_clade-2

    Graphical View of Domain Structure for InterPro Entry P15309

    ProtoNet protein and cluster: P15309

    1 Blocks protein domain: IPB000560 Histidine acid phosphatase

    UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309
    Similarity: Belongs to the histidine acid phosphatase family


    Find genes that share domains with ACPP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPAP_HUMAN, P15309
    Function: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic
    conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has
    lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma
    Function: Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG)
    neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate
    cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate
    Catalytic activity: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate
    Enzyme regulation: Phosphatase activity inhibited by L(+)-tartrate, and by its derivative,
    alpha-benzylaminobenzylphosphonic acid

         Genatlas biochemistry entry for ACPP:
    phosphatase acid,prostate

         Enzyme Numbers (IUBMB): EC 3.1.3.21 2 EC 3.1.3.51

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003993acid phosphatase activity IMP8132635
    GO:0005515protein binding IPI11067847
    GO:00082535'-nucleotidase activity IDA18940592
    GO:0016791phosphatase activity IMP18940592
    GO:0033265choline binding IEA--
         
    Find genes that share ontologies with ACPP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ACPP:
     Decreased viability with pacli  Increased cell death in DLD-1  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acpp):
     behavior/neurological  integument 

    Find genes that share phenotypes with ACPP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACPP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACPP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACPP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACPP

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACPP:
    hsa-let-7b-5p (MIRT032233)

    Block miRNA regulation of human, mouse, rat ACPP using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ACPP:
    hsa-miR-3128 hsa-miR-576-5p hsa-miR-2355-3p hsa-miR-590-3p hsa-miR-215 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidACPP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACPP
    Predesigned siRNA for gene silencing in human, mouse, rat ACPP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACPP

    Clone
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    OriGene ORF clones in mouse, rat for ACPP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACPP (NM_001134194)
    Sino Biological Human cDNA Clone for ACPP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACPP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACPP

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ACPP 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACPP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPAP_HUMAN, P15309: Isoform 1: Secreted
    PPAP_HUMAN, P15309: Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane;
    Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular
    vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the
    lysosome membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome5
    plasma membrane5
    vacuole5
    endoplasmic reticulum3
    golgi apparatus3
    mitochondrion3
    nucleus3
    cytoskeleton2
    cytosol2
    endosome2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IMP--
    GO:0005622intracellular IDA17658863
    GO:0005765lysosomal membrane IDA17897319
    GO:0005771multivesicular body IEA--

    Find genes that share ontologies with ACPP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACPP About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    ATP ITP metabolism0.31
    2Riboflavin metabolism
    Riboflavin metabolism


    Find genes that share SuperPaths with ACPP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ACPP
        ATP/ITP metabolism



    1 Kegg Pathway  (Kegg details for ACPP):
        Riboflavin metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACPP
    Interactions:

        GeneGlobe Interaction Network for ACPP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ACPP (P153091, 2, 3 ENSP000003230364) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-1222012,EBI-641062 MINT-8255912 MINT-8212366 MINT-8255748 I2D: score=2 STRING: ENSP00000269571
    MAPK1P284822, 3, ENSP000002158324MINT-8212394 I2D: score=1 STRING: ENSP00000215832
    SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    IGHMP018713I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006144purine nucleobase metabolic process IEA--
    GO:0006772thiamine metabolic process ISS--
    GO:0009117nucleotide metabolic process IEA--
    GO:0016311dephosphorylation IMP8132635
    GO:0046085adenosine metabolic process IDA18940592

    Find genes that share ontologies with ACPP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACPP (PPAP)

    6 HMDB Compounds for ACPP    About this table
    CompoundSynonyms CAS #PubMed Ids
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Riboflavin(-)-Riboflavin (see all 30)83-88-5--
    Tartaric acid(+)-(2R,3R)-Tartaric acid (see all 37)87-69-4--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for ACPP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-Benzyl-Aminobenzyl-Phosphonic Acid-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    N-Propyl-Tartramic Acid-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for ACPP gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    provenge 91.2 16 10873066 (2), 11099318 (2), 16736512 (2), 17696825 (1) (see all 9)
    estracyt 68.3 4 1715080 (1), 7840515 (1)
    nilutamide 65.5 6 8259343 (2), 7678043 (1), 1992599 (1)
    testosterone 64 108 7510912 (7), 1373297 (4), 11280747 (2), 8138434 (2) (see all 46)
    dihydrotestosterone 62.2 31 12362977 (3), 8653325 (3), 8827085 (2), 9506725 (2) (see all 8)
    phenylphosphate 61 3 11513970 (1), 15082403 (1)
    fmpp 60.2 2 7592741 (1)
    estramustine phosphate 57.4 5 7542158 (2), 7526970 (1), 8653325 (1)
    mians 55.5 2 17520089 (1), 12719131 (1)
    phosphotyrosine 54 9 7490893 (2), 8248785 (1), 11513970 (1), 8166732 (1) (see all 7)



    Find genes that share compounds with ACPP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACPP gene (2 alternative transcripts): 
    NM_001099.4  NM_001134194.1  

    Unigene Cluster for ACPP:

    Acid phosphatase, prostate
    Hs.433060  [show with all ESTs]
    Unigene Representative Sequence: NM_001099
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336375(uc010htp.2 uc003eon.3) ENST00000495911 ENST00000475741
    ENST00000351273(uc003eop.4) ENST00000493235 ENST00000489084 ENST00000483689
    ENST00000512463 ENST00000507647
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate ACPP:
    hsa-miR-3128 hsa-miR-576-5p hsa-miR-2355-3p hsa-miR-590-3p hsa-miR-215 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidACPP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ACPP
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ACPP (NM_001134194)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACPP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACPP
    Primer
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    OriGene qPCR primer pairs and template standards for ACPP
    OriGene qSTAR qPCR primer pairs in human, mouse for ACPP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACPP
      QuantiTect SYBR Green Assays in human, mouse, rat ACPP
      QuantiFast Probe-based Assays in human, mouse, rat ACPP

    Additional mRNA sequence: 

    AB102888.1 AK300540.1 BC007460.1 BC008493.1 BC016344.1 BC017877.1 M24902.1 M34840.1 
    X52174.1 X53605.1 

    Selected DOTS entries (see all 26):

    DT.80101926  DT.91984927  DT.433646  DT.87004158  DT.100817219  DT.91937774  DT.100817218  DT.120900128 
    DT.91722686  DT.420131  DT.91761053  DT.120900097  DT.433260  DT.91647907  DT.65288114  DT.91852927 
    DT.100780538  DT.120900095  DT.120900105  DT.120900108  DT.120900148  DT.91761070  DT.97783982  DT.120900101 

    Selected AceView cDNA sequences (see all 449):

    BF063890 BQ924880 BM693355 BF589624 BF060849 BM759329 AI597835 BF438310 
    AI547266 AA502799 BC017877 BQ000968 BM764818 BM773214 AA371312 AA371462 
    BF475839 BF476050 AI401663 AA573645 BX113133 BF060817 CB989650 AI670092 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACPP (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11
    SP1:                                      -     -                                               -     -         
    SP2:                                      -     -                                                               
    SP3:                                      -     -     -                                                         
    SP4:                                                                                                            
    SP5:                          -           -     -                                                               


    ECgene alternative splicing isoforms for ACPP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ACPP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAGAGAAC
    ACPP Expression
    About this image


    ACPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
    ACPP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACPP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433060

    UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309
    Tissue specificity: Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also
    expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic
    islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal
    structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform
    decreased in prostate cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ACPP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acpp1 , 5 acid phosphatase, prostate1, 5 82.86(n)1
    80.62(a)1
      9 (56.61 cM)5
    563181  NM_207668.21  NP_997551.11 
     1042882515 
    chicken
    (Gallus gallus)
    Aves ACPP1 acid phosphatase, prostate 61.21(n)
    55.06(a)
      776390  XM_001235913.2  XP_001235914.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACPP6
    acid phosphatase, prostate
    51(a)
    1 ↔ 1
    6(37933056-37968777)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia acpp1 acid phosphatase, prostate 58.03(n)
    52.07(a)
      101735257  XM_004915370.1  XP_004915427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Acph-13 acid phosphatase 37(a)
    (best of 5)
      3 99D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T13B5.33
    pho-61
    acid phosphatase3
    pho-61
    32(a)
    (best of 5)3
    43.24(n)1
    33.13(a)1
      II(1097327-1099531)3
    1861141  NM_072766.21  NP_505167.21 


    ENSEMBL Gene Tree for ACPP (if available)
    TreeFam Gene Tree for ACPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACPP gene
    ACP62  ACPT2  ACP22  
    2 SIMAP similar genes for ACPP using alignment to 5 protein entries:     PPAP_HUMAN (see all proteins):
    ACP2    ACPT

    Find genes that share paralogs with ACPP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACPP (see all 1237)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26054081,2
    F,H--132034216(-) ATGCAT/CGTGTG 2 -- us2k15Minor allele frequency- C:0.01NS EA WA 518
    rs718453531,2
    C--132034250(+) TTTTT-/TGGAGG 2 -- us2k10--------
    rs1410885451,2
    --132034254(+) TTGGAA/GGGGGG 2 -- us2k10--------
    rs37626711,2
    C--132034379(-) AGCCTG/ATAATC 2 -- us2k13Minor allele frequency- A:0.17NA 6
    rs37626701,2
    C--132034414(-) TAAAAC/ATACAA 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1124466431,2
    C,F--132034454(+) GGCTGA/GTCTCG 2 -- us2k13Minor allele frequency- G:0.40WA CSA 5
    rs1470384501,2
    --132034545(+) ATTTGC/TGCATG 2 -- us2k10--------
    rs1383486581,2
    C--132034546(+) TTTGCA/GCATGT 2 -- us2k10--------
    rs1439381731,2
    C--132034563(+) CTGCCA/GGAAGA 2 -- us2k10--------
    rs1440220191,2
    --132034567(+) CGGAAG/TAAGGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACPP (132036211 - 132087146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACPP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508245CNV Loss20534489
    nsv829728CNV Gain17160897

    Human Gene Mutation Database (HGMD): ACPP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACPP
    DNA2.0 Custom Variant and Variant Library Synthesis for ACPP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 171790    OMIM disorders: --

    14 diseases for ACPP:    
    About MalaCards
    prostatic hypertrophy    nephrogenic adenoma of the urethra    prostatic adenoma    prostatitis
    lymphoepithelioma-like carcinoma    endodermal sinus tumor    cloacogenic carcinoma    nephrogenic adenoma
    histoplasmosis    intravascular large b-cell lymphoma    adenomatoid tumor    malignant fibroxanthoma
    varicocele    prostate cancer

    18 diseases from the University of Copenhagen DISEASES database for ACPP:
    Prostate cancer     Carcinoma     Prostatic hypertrophy     Osteoporosis
    Giant cell tumor     Root resorption     Gaucher's disease     Leukemia
    Prostatitis     Arthritis     Osteopetrosis     Histiocytosis
    Histoplasmosis     Periodontal disease     Prostatic adenoma     Malignant fibroxanthoma
    Myeloma     Lymphoma

    Find genes that share disorders with ACPP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ACPP gene (see all 66)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 89 103 7683340 (3), 1965432 (2), 7691762 (2), 7649350 (2) (see all 58)
    prostate cancer 87 264 7602779 (5), 8564745 (4), 11351352 (4), 1380223 (4) (see all 99)
    prostatic adenocarcinoma 83.5 37 7525979 (5), 1699237 (2), 7514089 (2), 8958315 (1) (see all 20)
    benign prostatic hyperplasia 77.9 38 1723815 (2), 1385128 (2), 1700860 (1), 1701586 (1) (see all 24)
    lysosomal acid phosphatase 75.4 1 1720287 (1)
    prostate cancer stage d 71.7 1 17991541 (1)
    prostatic diseases 69.3 9 1721770 (2), 1693867 (1), 15623486 (1), 1280403 (1) (see all 6)
    adenocarcinoma 68.7 54 7840515 (3), 11888088 (2), 10738193 (2), 15379952 (2) (see all 29)
    bone metastases 63.2 15 7602779 (1), 11141722 (1), 1518166 (1), 8291878 (1) (see all 12)
    adenocarcinoma clear cell 61.7 5 7536368 (2), 9865832 (1), 7645457 (1)

    Genetic Association Database (GAD): ACPP
    Human Genome Epidemiology (HuGE) Navigator: ACPP (1 document)

    Export disorders for ACPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACPP gene, integrated from 10 sources (see all 568):
    (articles sorted by number of sources associating them with ACPP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. (PubMed id 9804805)1, 2, 9 Lacount M.W.... Lebioda L. (J. Biol. Chem. 1998)
    2. Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer. (PubMed id 19403677)1, 2, 9 Hong S....Silverman R.H. (J. Virol. 2009)
    3. Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. (PubMed id 15280042)1, 2, 9 Tanaka M.... Arai H. (FEBS Lett. 2004)
    4. Prostatic acid phosphatase expression in human tissues. (PubMed id 21487525)1, 2 Graddis T.J.... Trager J.B. (Int. J. Clin. Exp. Pathol. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth. (PubMed id 20498373)1, 2 Chuang T.D.... Lin M.F. (J. Biol. Chem. 2010)
    7. Semen-derived amyloid fibrils drastically enhance HIV infection. (PubMed id 18083097)1, 2 Munch J....Kirchhoff F. (Cell 2007)
    8. Prostatic acid phosphatase is not a prostate specific target. (PubMed id 17638863)1, 2 Quintero I.B.... Vihko P.T. (Cancer Res. 2007)
    9. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (Traffic 2007)
    10. Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design. (PubMed id 12525165)1, 2 Ortlund E.... Lebioda L. (Biochemistry 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55 HGNC: 125 AceView: ACPP Ensembl:ENSG00000014257 euGenes: HUgn55
    ECgene: ACPP Kegg: 55 H-InvDB: ACPP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ACPP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACPP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACPP gene:
    Search GeneIP for patents involving ACPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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