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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACPP Gene

protein-coding   GIFtS: 70
GCID: GC03P132036

Acid Phosphatase, Prostate

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acid Phosphatase, Prostate1 2     ACP-32
Thiamine Monophosphatase2 3     ACP32
5'-NT2 3     ecto-5'-nucleotidase2
5'-nucleotidase2 3     Prostatic Acid Phosphatase2
PAP2 3     Prostatic Acid Phosphotase2
TMPase2 3     EC 3.1.3.53
EC 3.1.3.23 8     Ecto-5'-nucleotidase3

External Ids:    HGNC: 1251   Entrez Gene: 552   Ensembl: ENSG000000142577   OMIM: 1717905   UniProtKB: P153093   

Export aliases for ACPP gene to outside databases

Previous GC identifers: GC03P128977 GC03P132781 GC03P133317 GC03P133357 GC03P133518 GC03P129415


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACPP Gene:
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and
orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the
prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this
gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal
pathway. (provided by RefSeq, Sep 2008)

GeneCards Summary for ACPP Gene: 
ACPP (acid phosphatase, prostate) is a protein-coding gene. Diseases associated with ACPP include prostate transitional cell carcinoma, and nephrogenic adenoma of the urethra, and among its related super-pathways are Purine metabolism. GO annotations related to this gene include protein homodimerization activity and acid phosphatase activity. An important paralog of this gene is ACP6.

UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309
Function: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic
conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has
lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma
Function: Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG)
neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate
cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling

Gene Wiki entry for ACPP (Prostatic acid phosphatase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACPP gene promoter:
         ER-alpha   Bach1   Sox5   HNF-3beta   NF-E2 p45   Evi-1   AREB6   FOXO1a   NF-E2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ACPP promoter sequence
   Search SABiosciences Chromatin IP Primers for ACPP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

ACPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACPP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P132036:  view genomic region     (about GC identifiers)

Start:
132,036,211 bp from pter      End:
132,087,146 bp from pter
Size:
50,936 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309 (See protein sequence)
Recommended Name: Prostatic acid phosphatase precursor  
Size: 386 amino acids; 44566 Da
Subunit: Homodimer; dimer formation is required for phosphatase activity (By similarity)
Subcellular location: Isoform 1: Secreted
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane;
Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular
vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the
lysosome membrane
Miscellaneous: Used as a diagnostic tool for staging metastatic prostatic cancer
6/8 PDB 3D structures from and Proteopedia for ACPP (see all 8):
1CVI (3D)        1ND5 (3D)        1ND6 (3D)        2HPA (3D)        2L3H (3D)        2L77 (3D)    
Secondary accessions: D3DNC6 Q96KY0 Q96QK9 Q96QM0
Alternative splicing: 2 isoforms:  P15309-1   P15309-2   

Explore the universe of human proteins at neXtProt for ACPP: NX_P15309

Explore proteomics data for ACPP at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated
    with partially sialylated triantennary complex oligosaccharides
  • UniProtKB: Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms
    amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach
    them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol
    epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV
    infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus)
    infection
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15309

  • 4/5 DME Specific Peptides for ACPP (P15309) (see all 5)
     RLQGGVL  DRTLMSA  WQPIPVHT  WPQGFGQLT 

    ACPP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACPP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001090.2  NP_001127666.1  

    ENSEMBL proteins: 
     ENSP00000337471   ENSP00000418366   ENSP00000417744   ENSP00000323036   ENSP00000422036  

    Human Recombinant Protein Products for ACPP: 
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    Novus Biologicals ACPP Proteins
    Novus Biologicals ACPP Lysate
    Sino Biological Recombinant Protein for ACPP
    Sino Biological Cell Lysate for ACPP 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005622intracellular IDA17658863
    GO:0005765lysosomal membrane IDA17897319
    GO:0005771multivesicular body IEA--
    GO:0005886plasma membrane IDA17658863

    ACPP for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000560 His_Pase_superF_clade-2

    Graphical View of Domain Structure for InterPro Entry P15309

    ProtoNet protein and cluster: P15309

    1 Blocks protein domain: IPB000560 Histidine acid phosphatase

    UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309
    Similarity: Belongs to the histidine acid phosphatase family


    ACPP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPAP_HUMAN, P15309
    Function: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic
    conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has
    lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma
    Function: Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG)
    neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate
    cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate
    Catalytic activity: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate
    Enzyme regulation: Phosphatase activity inhibited by L(+)-tartrate, and by its derivative,
    alpha-benzylaminobenzylphosphonic acid

         Genatlas biochemistry entry for ACPP:
    phosphatase acid,prostate

         Enzyme Numbers (IUBMB): EC 3.1.3.21 2 EC 3.1.3.51

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003993acid phosphatase activity IEA--
    GO:00082535'-nucleotidase activity IEA--
    GO:0033265choline binding IEA--
    GO:0042802identical protein binding IPI18083097
    GO:0042803protein homodimerization activity IEA--
         
    ACPP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ACPP:
     Decreased viability with pacli  Increased cell death in DLD-1  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acpp):
     behavior/neurological  integument 

    ACPP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACPP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACPP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACPP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACPP 

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ACPP:
    hsa-miR-3128 hsa-miR-576-5p hsa-miR-2355-3p hsa-miR-590-3p hsa-miR-215 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidACPP 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for ACPP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACPP
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACPP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACPP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Purine metabolism
    ATP/ITP metabolism0.31
    2Riboflavin metabolism
    Riboflavin metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ACPP
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for ACPP
        ATP/ITP metabolism



    1         Kegg Pathway  (Kegg details for ACPP):
        Riboflavin metabolism


    ACPP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACPP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for ACPP (P153091, 2, 3 ENSP000003230364) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-8255912 MINT-8212366 MINT-8255748 I2D: score=2 STRING: ENSP00000269571
    MAPK1P284822, 3, ENSP000002158324MINT-8212394 I2D: score=1 STRING: ENSP00000215832
    SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    IGHMP018713I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006144purine nucleobase metabolic process IEA--
    GO:0009117nucleotide metabolic process IEA--
    GO:0016311dephosphorylation ----
    GO:0046085adenosine metabolic process IEA--

    ACPP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACPP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACPP (PPAP)

    6 HMDB Compounds for ACPP    About this table
    CompoundSynonyms CAS #PubMed Ids
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Riboflavin(-)-Riboflavin (see all 30)83-88-5--
    Tartaric acid(+)-(2R,3R)-Tartaric acid (see all 37)87-69-4--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for ACPP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-Benzyl-Aminobenzyl-Phosphonic Acid-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    N-Propyl-Tartramic Acid-- --target--17139284 17016423

    10/65 Novoseek inferred chemical compound relationships for ACPP gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    provenge 91.2 16 10873066 (2), 11099318 (2), 16736512 (2), 17696825 (1) (see all 9)
    estracyt 68.3 4 1715080 (1), 7840515 (1)
    nilutamide 65.5 6 8259343 (2), 7678043 (1), 1992599 (1)
    testosterone 64 108 7510912 (7), 1373297 (4), 11280747 (2), 8138434 (2) (see all 46)
    dihydrotestosterone 62.2 31 12362977 (3), 8653325 (3), 8827085 (2), 9506725 (2) (see all 8)
    phenylphosphate 61 3 11513970 (1), 15082403 (1)
    fmpp 60.2 2 7592741 (1)
    estramustine phosphate 57.4 5 7542158 (2), 7526970 (1), 8653325 (1)
    mians 55.5 2 17520089 (1), 12719131 (1)
    phosphotyrosine 54 9 7490893 (2), 8248785 (1), 11513970 (1), 8166732 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about ACPP / PPAP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACPP gene (2 alternative transcripts): 
    NM_001099.4  NM_001134194.1  

    Unigene Cluster for ACPP:

    Acid phosphatase, prostate
    Hs.433060  [show with all ESTs]
    Unigene Representative Sequence: NM_001099
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336375(uc010htp.2 uc003eon.3) ENST00000495911 ENST00000475741
    ENST00000351273(uc003eop.4) ENST00000493235 ENST00000489084 ENST00000483689
    ENST00000512463 ENST00000507647
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ACPP:
    hsa-miR-3128 hsa-miR-576-5p hsa-miR-2355-3p hsa-miR-590-3p hsa-miR-215 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidACPP 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB102888.1 AK300540.1 BC007460.1 BC008493.1 BC016344.1 BC017877.1 M24902.1 M34840.1 
    X52174.1 X53605.1 

    24/26 DOTS entries (see all 26):

    DT.80101926  DT.91984927  DT.433646  DT.87004158  DT.100817219  DT.91937774  DT.100817218  DT.120900128 
    DT.91722686  DT.420131  DT.91761053  DT.120900097  DT.433260  DT.91647907  DT.65288114  DT.91852927 
    DT.100780538  DT.120900095  DT.120900105  DT.120900108  DT.120900148  DT.91761070  DT.97783982  DT.120900101 

    24/449 AceView cDNA sequences (see all 449):

    BQ934114 BQ101187 AA573645 BQ000968 BF476609 AI685444 BF475839 AI597835 
    AA371312 BE856038 AI670092 BM759329 AA371462 CB989650 BF063890 AA502799 
    AI401663 BF060817 BX113133 BM764818 BF060849 BF000933 BQ924880 BF589624 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ACPP (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11
    SP1:                                      -     -                                               -     -         
    SP2:                                      -     -                                                               
    SP3:                                      -     -     -                                                         
    SP4:                                                                                                            
    SP5:                          -           -     -                                                               


    ECgene alternative splicing isoforms for ACPP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACPP expression in normal human tissues (normalized intensities)      ACPP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAGAGAAC
    ACPP Expression
    About this image


    ACPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Prostate (Endocrine System)    fully expand to see all 2 entries
             prostate ; glandular cells   
             prostate gland   
     
     Lung (Respiratory System)
             Human Pulmonary Fibroblasts (HPF)   
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Uterus (Reproductive System)
             cervix   
     
     Blood (Hematopoietic System)
             monocyte   

    See ACPP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACPP

    SOURCE GeneReport for Unigene cluster: Hs.433060

    UniProtKB/Swiss-Prot: PPAP_HUMAN, P15309
    Tissue specificity: Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also
    expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic
    islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal
    structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform
    decreased in prostate cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACPP gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acpp1 , 5 acid phosphatase, prostate1, 5 82.25(n)1
    79.38(a)1
      9 (56.61 cM)5
    563181  NM_207668.21  NP_997551.11 
     1042882515 
    chicken
    (Gallus gallus)
    Aves ACPP1 acid phosphatase, prostate 59.8(n)
    54.17(a)
      776390  XM_001235913.1  XP_001235914.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACPP6
    Uncharacterized protein
    50(a)
    1 ↔ 1
    6(37933056-37968777)
    fruit fly
    (Drosophila melanogaster)
    Insecta Acph-13 acid phosphatase 37(a)
    (best of 5)
      3 99D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T13B5.33 acid phosphatase 32(a)
    (best of 5)
      II(1097327-1099531)   --


    ENSEMBL Gene Tree for ACPP (if available)
    TreeFam Gene Tree for ACPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACPP gene
    ACP62  ACPT2  ACP22  
    2 SIMAP similar genes for ACPP using alignment to 6 protein entries:     PPAP_HUMAN (see all proteins):
    ACP2    ACPT

    ACPP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1237 SNPs in ACPP are shown (see all 1237)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26054081,2
    F,H--132034216(-) ATGCAT/CGTGTG 2 -- us2k15Minor allele frequency- C:0.01NS EA WA 518
    rs718453531,2
    C--132034250(+) TTTTT-/TGGAGG 2 -- us2k10--------
    rs1410885451,2
    --132034254(+) TTGGAA/GGGGGG 2 -- us2k10--------
    rs37626711,2
    C--132034379(-) AGCCTG/ATAATC 2 -- us2k13Minor allele frequency- A:0.17NA 6
    rs37626701,2
    C--132034414(-) TAAAAC/ATACAA 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1124466431,2
    C,F--132034454(+) GGCTGA/GTCTCG 2 -- us2k13Minor allele frequency- G:0.40WA CSA 5
    rs1470384501,2
    --132034545(+) ATTTGC/TGCATG 2 -- us2k10--------
    rs1383486581,2
    C--132034546(+) TTTGCA/GCATGT 2 -- us2k10--------
    rs1439381731,2
    C--132034563(+) CTGCCA/GGAAGA 2 -- us2k10--------
    rs1440220191,2
    --132034567(+) CGGAAG/TAAGGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACPP (132036211 - 132087146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACPP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508245CNV Loss20534489
    nsv829728CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 171790    OMIM disorders: --

    20/60 diseases for ACPP (see all 60):    About MalaCards
    prostate transitional cell carcinoma    nephrogenic adenoma of the urethra    cloacogenic carcinoma    urethra cancer
    sphenoid sinusitis    prostatic adenoma    intravascular large b-cell lymphoma    endodermal sinus tumor
    nephrogenic adenoma    prostatic hypertrophy    lymphoepithelioma-like carcinoma    prostate adenocarcinoma
    phyllode tumor    varicocele    follicular adenoma    adenomatoid tumor
    prostate disease    prostatitis    male breast cancer    histoplasmosis

    18 diseases from the University of Copenhagen DISEASES database for ACPP:
    Prostate cancer     Carcinoma     Prostatic hypertrophy     Osteoporosis
    Giant cell tumor     Root resorption     Gaucher's disease     Leukemia
    Prostatitis     Arthritis     Osteopetrosis     Histiocytosis
    Histoplasmosis     Periodontal disease     Prostatic adenoma     Malignant fibroxanthoma
    Myeloma     Lymphoma

    ACPP for disorders           About GeneDecksing

    10/66 Novoseek inferred disease relationships for ACPP gene (see all 66)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 89 103 7683340 (3), 1965432 (2), 7691762 (2), 7649350 (2) (see all 58)
    prostate cancer 87 264 7602779 (5), 8564745 (4), 11351352 (4), 1380223 (4) (see all 99)
    prostatic adenocarcinoma 83.5 37 7525979 (5), 1699237 (2), 7514089 (2), 8958315 (1) (see all 20)
    benign prostatic hyperplasia 77.9 38 1723815 (2), 1385128 (2), 1700860 (1), 1701586 (1) (see all 24)
    lysosomal acid phosphatase 75.4 1 1720287 (1)
    prostate cancer stage d 71.7 1 17991541 (1)
    prostatic diseases 69.3 9 1721770 (2), 1693867 (1), 15623486 (1), 1280403 (1) (see all 6)
    adenocarcinoma 68.7 54 7840515 (3), 11888088 (2), 10738193 (2), 15379952 (2) (see all 29)
    bone metastases 63.2 15 7602779 (1), 11141722 (1), 1518166 (1), 8291878 (1) (see all 12)
    adenocarcinoma clear cell 61.7 5 7536368 (2), 9865832 (1), 7645457 (1)

    Genetic Association Database (GAD): ACPP
    Human Genome Epidemiology (HuGE) Navigator: ACPP (1 document)

    Export disorders for ACPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACPP gene, integrated from 9 sources (see all 564):
    (articles sorted by number of sources associating them with ACPP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. (PubMed id 9804805)1, 2, 9 Lacount M.W.... Lebioda L. (1998)
    2. Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer. (PubMed id 19403677)1, 2, 9 Hong S....Silverman R.H. (2009)
    3. Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. (PubMed id 15280042)1, 2, 9 Tanaka M....Arai H. (2004)
    4. Prostatic acid phosphatase expression in human tissues. (PubMed id 21487525)1, 2 Graddis T.J.... Trager J.B. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Human prostatic acid phosphatase, an authentic tyrosi ne phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell grow th. (PubMed id 20498373)1, 2 Chuang T.D....Lin M.F. (2010)
    7. Semen-derived amyloid fibrils drastically enhance HIV infection. (PubMed id 18083097)1, 2 Munch J....Kirchhoff F. (2007)
    8. Prostatic acid phosphatase is not a prostate specific target. (PubMed id 17638863)1, 2 Quintero I.B....Vihko P.T. (2007)
    9. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (2007)
    10. Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design. (PubMed id 12525165)1, 2 Ortlund E....Lebioda L. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55 HGNC: 125 AceView: ACPP Ensembl:ENSG00000014257 euGenes: HUgn55
    ECgene: ACPP Kegg: 55 H-InvDB: ACPP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACPP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACPP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACPP gene:
    Search GeneIP for patents involving ACPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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