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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACP6 Gene

protein-coding   GIFtS: 59
GCID: GC01M147119

Acid Phosphatase 6, Lysophosphatidic

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acid Phosphatase 6, Lysophosphatidic1 2 3     PACPL12 3
Acid Phosphatase-Like Protein 12 3     Acid Phosphatase Like 12
ACPL12 3     Lysophosphatidic Acid Phosphatase Type 62
LPAP2 3     EC 3.1.3.23

External Ids:    HGNC: 296091   Entrez Gene: 512052   Ensembl: ENSG000001628367   OMIM: 6114715   UniProtKB: Q9NPH03   

Export aliases for ACP6 gene to outside databases

Previous GC identifers: GC01M145333 GC01M143844 GC01M144463 GC01M144626 GC01M144343 GC01M145585 GC01M120532


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ACP6 Gene: 
ACP6 (acid phosphatase 6, lysophosphatidic) is a protein-coding gene. Diseases associated with ACP6 include atrioventricular septal defect, and tetralogy of fallot, and among its related super-pathways are NAD salvage pathway III. GO annotations related to this gene include acid phosphatase activity. An important paralog of this gene is ACPP.

UniProtKB/Swiss-Prot: PPA6_HUMAN, Q9NPH0
Function: Hydrolyzes lysophosphatidic acid to monoacylglycerol

Gene Wiki entry for ACP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167185.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACP6 gene promoter:
         HFH-3   AP-2rep   Pax-5   AP-4   RORalpha1   AREB6   FOXI1   FOXO4   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21

ACP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACP6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M147119:  view genomic region     (about GC identifiers)

Start:
147,119,168 bp from pter      End:
147,142,634 bp from pter
Size:
23,467 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPA6_HUMAN, Q9NPH0 (See protein sequence)
Recommended Name: Lysophosphatidic acid phosphatase type 6 precursor  
Size: 428 amino acids; 48854 Da
Subcellular location: Secreted (Probable)
Caution: It is uncertain whether Met-1 or Met-8 is the initiator
Caution: Was originally (PubMed:10506173) reported to be located in the mitochondrion, but the evidence seems to
be weak and contradictory with the presence of a cleaved signal sequence
Sequence caution: Sequence=BAA89311.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD92485.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q59G61 Q5T490 Q6IAQ3 Q7LG81 Q9UIG6
Alternative splicing: 2 isoforms:  Q9NPH0-1   Q9NPH0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACP6: NX_Q9NPH0

Explore proteomics data for ACP6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPH0

  • ACP6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACP6 Protein Expression
    REFSEQ proteins: NP_057445.4  
    ENSEMBL proteins: 
     ENSP00000358241   ENSP00000376714  

    Human Recombinant Protein Products for ACP6: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACP6
    OriGene Protein Over-expression Lysate for ACP6
    OriGene MassSpec for ACP6 
    OriGene Custom Protein Services for ACP6
    GenScript Custom Purified and Recombinant Proteins Services for ACP6
    Novus Biologicals ACP6 Protein
    Novus Biologicals ACP6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACP6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IDA12010880
    GO:0005739mitochondrion IDA10506173

    ACP6 for ontologies           About GeneDecksing



    ACP6 Antibody Products: 
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    Abcam antibodies for ACP6
    Cloud-Clone Corp. Antibodies for ACP6 
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    LSBio Antibodies in human, mouse, rat for ACP6 

    Assay Products for ACP6: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACP6 
    Cloud-Clone Corp. CLIAs for ACP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000560 His_Pase_superF_clade-2

    Graphical View of Domain Structure for InterPro Entry Q9NPH0

    ProtoNet protein and cluster: Q9NPH0

    1 Blocks protein domain: IPB000560 Histidine acid phosphatase

    UniProtKB/Swiss-Prot: PPA6_HUMAN, Q9NPH0
    Similarity: Belongs to the histidine acid phosphatase family


    ACP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPA6_HUMAN, Q9NPH0
    Function: Hydrolyzes lysophosphatidic acid to monoacylglycerol
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate
    Induction: Induced with the differentiation from myoblast to myotube

         Enzyme Number (IUBMB): EC 3.1.3.21

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003993acid phosphatase activity IEA--
    GO:0052642lysophosphatidic acid phosphatase activity IDA10506173
         
    ACP6 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for ACP6:
     Apoptosis resistance  Decreased focal adhesion (FA)   G0/1 arrest  Increased G1 DNA content 
     Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Acp6):
     normal 

    ACP6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACP6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACP6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACP6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACP6
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ACP6:
    hsa-miR-551b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACP6
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ACP6

    Clone
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    OriGene clones in human, mouse for ACP6 (see all 8)
    OriGene ORF clones in mouse, rat for ACP6
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    GenScript: all cDNA clones in your preferred vector: ACP6 (NM_016361)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACP6
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                         Customized lentivirus expression plasmids for stable overexpression of ACP6 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACP6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACP6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nicotinate metabolism
    NAD salvage pathway II0.42
    2Riboflavin metabolism
    Riboflavin metabolism
    3NAD phosphorylation and dephosphorylation
    NAD phosphorylation and dephosphorylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ACP6
        NAD phosphorylation and dephosphorylation
    NAD salvage pathway II


    1         Kegg Pathway  (Kegg details for ACP6):
        Riboflavin metabolism


    ACP6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for ACP6 (Q9NPH02, 3 ENSP000003582414) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC35F6Q8N3572, 3, ENSP000003455284MINT-65571 I2D: score=5 STRING: ENSP00000345528
    GNG7O602622, 3, ENSP000003715944MINT-65570 I2D: score=5 STRING: ENSP00000371594
    LIMS1P480593, ENSP000003317754I2D: score=1 STRING: ENSP00000331775
    RGS10O436653, ENSP000003580994I2D: score=1 STRING: ENSP00000358099
    DHCR7Q9UBM73, ENSP000003477174I2D: score=1 STRING: ENSP00000347717
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006644phospholipid metabolic process IMP10506173
    GO:2001311lysobisphosphatidic acid metabolic process IDA--

    ACP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACP6 (PPA6)

    10/78 HMDB Compounds for ACP6 (see all 78)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Arachidonylglycerol2-Arachidonyl glycerol;(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid (see all 21)53847-30-6--
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----

    2 Novoseek inferred chemical compound relationships for ACP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monoacylglycerol 77.6 2 10506173 (1), 16685394 (1)
    lipid 15.7 3 10506173 (2), 16685394 (1)

    Search CenterWatch for drugs/clinical trials and news about ACP6 / PPA6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACP6 gene: 
    NM_016361.4  

    Unigene Cluster for ACP6:

    Acid phosphatase 6, lysophosphatidic
    Hs.562154  [show with all ESTs]
    Unigene Representative Sequence: AB209248
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460583 ENST00000369238(uc001epr.2 uc009wjj.1) ENST00000487562
    ENST00000493129 ENST00000392988
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACP6
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ACP6:
    hsa-miR-551b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACP6
    Clone
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    OriGene ORF clones in mouse, rat for ACP6
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    GenScript: all cDNA clones in your preferred vector: ACP6 (NM_016361)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACP6
    Sirion Biotech Customized lentivirus for stable overexpression of ACP6 
                         Customized lentivirus expression plasmids for stable overexpression of ACP6 
    Primer
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    OriGene qPCR primer pairs and template standards for ACP6
    OriGene qSTAR qPCR primer pairs in human, mouse for ACP6
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACP6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACP6

    Additional mRNA sequence: 

    AB030039.2 AB031478.1 AB209248.1 AK000657.1 AK308593.1 AK310693.1 AY358552.1 BC009965.1 
    BC011644.2 BC034686.1 CR457101.1 

    11 DOTS entries:

    DT.212192  DT.212196  DT.100830788  DT.103871  DT.91694818  DT.95071211  DT.121354124  DT.91761902 
    DT.95072602  DT.121354157  DT.439710 

    24/166 AceView cDNA sequences (see all 166):

    CD627837 BG424230 BX118717 CR611952 AA883812 CR598748 CR620074 AA307227 
    CR613106 BM755981 AA923256 BM129832 BM744030 BI771513 CD627829 BM018871 
    BG338368 AB031478 AL524683 AI801139 AY358552 BM711018 CR457101 CD627831 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ACP6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
    SP1:                    -                 -                             -                                   -         
    SP2:                                      -                                                                           
    SP3:                                                                                                                  
    SP4:                    -     -     -     -     -                       -                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ACP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCTGCTC
    ACP6 Expression
    About this image


    See ACP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACP6

    SOURCE GeneReport for Unigene cluster: Hs.562154

    UniProtKB/Swiss-Prot: PPA6_HUMAN, Q9NPH0
    Tissue specificity: Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and
    weakly expressed in thymus and colon

        SABiosciences Custom PCR Arrays for ACP6
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACP6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACP6 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acp61 , 5 acid phosphatase 6, lysophosphatidic1, 5 81.77(n)1
    77.46(a)1
      3 (42.04 cM)5
    666591  NM_019800.41  NP_062774.21 
     971587775 
    chicken
    (Gallus gallus)
    Aves ACP61 acid phosphatase 6, lysophosphatidic 64.12(n)
    60.34(a)
      418458  XM_416667.3  XP_416667.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACP66
    acid phosphatase 6, lysophosphatidic
    58(a)
    1 ↔ 1
    3(162104656-162119235)
    zebrafish
    (Danio rerio)
    Actinopterygii acp61 acid phosphatase 6, lysophosphatidic 55.2(n)
    45.97(a)
      558758  NM_001110380.1  NP_001103850.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pho-86
    pho-96
    (see all 4)
    Protein PHO-9
    (see all 4)
    20(a)
    20(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    V(11833629-11835651)
    III(2757168-2760816)


    ENSEMBL Gene Tree for ACP6 (if available)
    TreeFam Gene Tree for ACP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACP6 gene
    ACPP2  ACPT2  ACP22  

    ACP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/513 SNPs in ACP6 are shown (see all 513)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154256171,2
    F--147118701(+) TGACTG/ATTCCC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1488143311,2
    --147118790(+) ATACAC/GCACTG 1 -- int10--------
    rs1435078471,2
    --147119110(+) CTTACA/CTTATA 1 -- int10--------
    rs1874070291,2
    C--147119177(+) TTGTAA/TAAAGG 1 -- ut310--------
    rs2021202911,2
    --147119212(+) CCTGCC/TTTTAT 1 -- ut310--------
    rs1379870971,2
    C,F--147119257(+) CTGAGT/ATTGAG 2 /T /S mis12Minor allele frequency- A:0.01NA EU 5873
    rs13441,2
    C,F,O,A,H--147119273(+) AGTGCG/ATGGTA 2 /H syn135Minor allele frequency- A:0.50MN EA NS NA CSA WA EU 10565
    rs1143969491,2
    C,F--147119308(+) TGACAT/CGGCAT 2 /M /V mis12Minor allele frequency- C:0.01WA NA 4668
    rs1425754281,2
    C--147119380(+) AAGAAA/CCATAA 1 -- int10--------
    rs1169224641,2
    C,F--147119637(+) CTGGGG/ACGTGC 1 -- int11Minor allele frequency- A:0.02EA 120

    HapMap Linkage Disequilibrium report for ACP6 (147119168 - 147142634 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ACP6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831426CNV Loss17160897
    nsv872266CNV Gain21882294
    nsv7181OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611471    OMIM disorders: --

    8 diseases for ACP6:    About MalaCards
    atrioventricular septal defect    tetralogy of fallot    esophageal squamous cell carcinoma    esophagitis
    squamous cell carcinoma    alcoholism    ovarian cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ACP6:
    Atrioventricular septal defect

    ACP6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACP6
    Human Genome Epidemiology (HuGE) Navigator: ACP6 (1 document)

    Export disorders for ACP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACP6 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ACP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis. (PubMed id 10506173)1, 2, 3, 9 Hiroyama M. and Takenawa T. (1999)
    2. Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum. (PubMed id 12010880)1, 2, 3, 9 Takayama I.... Fujino M.A. (2002)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51205 HGNC: 29609 AceView: ACP6 Ensembl:ENSG00000162836 euGenes: HUgn51205
    ECgene: ACP6 Kegg: 51205 H-InvDB: ACP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACP6 gene:
    Search GeneIP for patents involving ACP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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