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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACP2 Gene

protein-coding   GIFtS: 62
GCID: GC11M047260

acid phosphatase 2, lysosomal

 Explore 9 diseases affiliated with
ACP2 via our new
 Human Malady Compendium 
Biological research products
for ACP2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Acid Phosphatase 2, Lysosomal1 2
LAP2 3
EC 3.1.3.23 8
Lysosomal Acid Phosphatase2

External Ids:    HGNC: 1231   Entrez Gene: 532   Ensembl: ENSG000001345757   OMIM: 1716505   UniProtKB: P111173   

Export aliases for ACP2 gene to outside databases

Previous GC identifers: GC11M049200 GC11M048138 GC11M047292 GC11M047225 GC11M047218 GC11M046959


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACP2:
This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from
red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze
orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause
acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been
identified for this gene. (provided by RefSeq, Aug 2008)

Gene Wiki entry for ACP2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACP2 gene promoter:
         COUP-TF1   NF-1/L   NF-1   MAZR   COUP   Nkx2-5   HNF-4alpha2   GATA-2   HNF-4alpha1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2|11p12-p11   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ACP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M047260:  view genomic region     (about GC identifiers)

Start:
47,260,853 bp from pter      End:
47,270,457 bp from pter
Size:
9,605 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPAL_HUMAN, P11117 (See protein sequence)
Recommended Name: Lysosomal acid phosphatase precursor  
Size: 423 amino acids; 48344 Da
Subcellular location: Lysosome membrane; Single-pass membrane protein; Lumenal side. Lysosome lumen. Note=The soluble
form arises by proteolytic processing of the membrane-bound form
Secondary accessions: E9PCI1 Q561W5 Q9BTU7
Alternative splicing: 2 isoforms:  P11117-1   P11117-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACP2: NX_P11117

Post-translational modifications:

  • The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal
  • cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen1
  • N-glycosylated. The intermediates formed during enzymatic deglycosylation suggest that all eight predicted
  • N-glycosylation sites are used1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P11117

  • 4/19 DME Specific Peptides for ACP2 (P11117) (see all 19)
     VYDTLFC  RLQGGVL  DRTLMSA  PEYQNES 

    ACP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124536.1  NP_001601.1  

    ENSEMBL proteins: 
     ENSP00000256997   ENSP00000436658   ENSP00000432205   ENSP00000435261   ENSP00000432439  
     ENSP00000432466   ENSP00000436487   ENSP00000434205   ENSP00000414911   ENSP00000436828  
     ENSP00000441933  

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    Novus Biologicals ACP2 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ACP2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IDA3160696
    GO:0005765lysosomal membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0019717synaptosome ----
    GO:0031410cytoplasmic vesicle ----


    ACP2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACP2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000560 His_Pase_superF_clade-2

    Graphical View of Domain Structure for InterPro Entry P11117

    ProtoNet protein and cluster: P11117

    1 Blocks protein family: IPB000560 Histidine acid phosphatase

    UniProtKB/Swiss-Prot: PPAL_HUMAN, P11117
    Similarity: Belongs to the histidine acid phosphatase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PPAL_HUMAN, P11117
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate

         Genatlas biochemistry entry for ACP2:
    phosphatase acid,lysosomal

    Enzyme Number (IUBMB): EC 3.1.3.21 2

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding ----
    GO:0003993acid phosphatase activity IEA--
    GO:0004721phosphoprotein phosphatase activity ----


    ACP2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ACP2:
     Decreased nuclei size in G2M 

    Animal Models:
         Mouse knock-out Acp2tm1Psa for ACP2
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Acp2):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  nervous system  other  renal/urinary system 
     skeleton 

    ACP2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ATP/ITP metabolism
    ATP/ITP metabolism1.00
    ATP/ITP metabolism0.98
    2Lysosome
    Lysosome1.00
    3Riboflavin metabolism
    Riboflavin metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ACP2
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for ACP2
        ATP/ITP metabolism


    2         Kegg Pathways  (Kegg details for ACP2):
        Riboflavin metabolism
    Lysosome


    ACP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACP2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ACP2 (P111173 ENSP000002569974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CBX1ENSP000002256034STRING: ENSP00000225603
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0007040lysosome organization IEA--
    GO:0010033response to organic substance ----
    GO:0048102autophagic cell death ----


    ACP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACP2

    8 HMDB Compounds for ACP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--
    3 Novoseek chemical compound relationships for ACP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 56.3 3 2209556 (1), 1353723 (1)
    phenylalanine 42.9 2 8509395 (1), 2209556 (1)
    tyrosine 21.1 13 11801736 (5), 1425575 (3), 8509395 (1), 2209556 (1)

    Search CenterWatch for drugs/clinical trials and news about ACP2 / PPAL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACP2 gene (2 alternative transcripts): 
    NM_001131064.1  NM_001610.2  

    Unigene Cluster for ACP2:

    Acid phosphatase 2, lysosomal
    Hs.532492  [show with all ESTs]
    Unigene Representative Sequence: AK097626
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256997(uc010rhe.2 uc001nei.3 uc009ylj.3 uc010rhf.2 uc010rhg.2 uc010rhh.2 uc010rhi.1 uc009ylk.2 uc010rhj.1)
    ENST00000534752 ENST00000529444 ENST00000534448 ENST00000527256 ENST00000531004
    ENST00000533929 ENST00000525230 ENST00000531547 ENST00000529663 ENST00000524769
    ENST00000530453 ENST00000444355 ENST00000529788 ENST00000537863

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    hsa-miR-140-5p hsa-miR-185* hsa-miR-3202 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmidACP2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK097626.1 AK298122.1 AK298439.1 AK299382.1 AK300569.1 AK300911.1 AK300931.1 AK301860.1 
    AK303894.1 AK308512.1 AK311431.1 AY007137.1 BC003160.1 BC093010.1 X12548.1 

    24/26 DOTS entries (see all 26):

    DT.453062  DT.120730697  DT.120730669  DT.120730611  DT.120730662  DT.100826998  DT.95371018  DT.120730590 
    DT.92450332  DT.120730554  DT.100688828  DT.40115915  DT.120730700  DT.100740730  DT.100757035  DT.100827000 
    DT.100826997  DT.100827002  DT.92450333  DT.95371021  DT.120730612  DT.100826996  DT.120730574  DT.120730596 

    24/293 AceView cDNA sequences (see all 293):

    BM848638 BU845972 CA395596 AU124511 BI258108 CR615614 CD516138 CD366909 
    CB148178 CB139437 AA577168 AU077098 BI828921 AU107377 BM762739 BQ437958 
    BQ278048 BI223475 BI834101 BM842290 BQ637068 X12548 BM842787 AU107373 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ACP2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                -           -                 -     -                                             
    SP2:                                -           -                 -                                                   
    SP3:                                                                                                                  
    SP4:                                -                                                                                 
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ACP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGTTGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ACP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACP2

    SOURCE GeneReport for Unigene cluster: Hs.532492
        SABiosciences Expression via Pathway-Focused PCR Array including ACP2: 
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACP2 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ACP21 acid phosphatase 2, lysosomal 68.99(n)
    71.15(a)
      428864  NM_001031548.1  NP_001026719.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACP26
    --
    68(a)
    1 ↔ 1
    1(43715166-43730500)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.32822 Transcribed sequence with weak similarity to protein more 73.94(n)    137724217 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.252432 Transcribed sequence with weak similarity to protein more 72.14(n)    CA471777.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Acph-11 , 3 acid phosphatase3
    Acid phosphatase 11
    35(a)
    (best of 5)3
    48.34(n)1
    36.39(a)1
      3 99D13
    484451  NM_080178.41  NP_524917.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T13B5.33
    pho-51
    acid phosphatase3
    Protein PHO-51
    33(a)
    (best of 5)3
    43.68(n)1
    34.35(a)1
      II(1097327-1099531)3
    1760301  NM_066203.61  NP_498604.21 


    ENSEMBL Gene Tree for ACP2 (if available)
    TreeFam Gene Tree for ACP2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACP2 gene
    ACPP2  ACP62  ACPT2  
    2 SIMAP similar genes for ACP2 using alignment to 10 protein entries:     PPAL_HUMAN (see all proteins):
    ACPP    ACPT

    ACP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/213 NCBI SNPs in ACP2 are shown (see all 213    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10502441,2
    C,F,H,--46959457(+) GGTGGC/TGATTT 1 -- ut3111Minor allele frequency- T:0.04NS NA WA EA 782
    rs46477601,2
    C,F,H,--46959531(+) TGGGAC/ATGGGA 1 -- ut319Minor allele frequency- A:0.02NS NA 838
    rs46477611,2
    C,F,--46959713(+) GTGCTCA/-CTTTT 1 -- ut311Minor allele frequency- -:0.01NS 178
    rs46477621,2
    C,F,H,--46959808(+) GAAATG/AAAGAA 1 -- ds50016Minor allele frequency- A:0.01NS EA WA 710
    rs46401,2
    C,F,H,--46960051(-) AGGACG/AGAAGG 1 -- ds5001 ese325Minor allele frequency- A:0.05NS MN EA NA WA 2740
    rs46477631,2
    C,F--46960077(+) GTGACAAC/-GATTC 1 -- ds50011Minor allele frequency- -:0.02NS 150
    rs21670801,2
    C,F,A,H,--46961820(-) CCGCCC/TGCCTT 1 -- int13Minor allele frequency- T:0.50NA 6
    rs124168901,2
    C,F,H,--46962061(+) taaaaG/Aaagtt 1 -- int11Minor allele frequency- A:0.50NA 4
    rs752617451,2
    C,--46962371(+) AACTTT/GGAGAT 1 -- int12Minor allele frequency- G:0.04WA 120
    rs1121396051,2
    F--46963297(+) TGCCAC/ATCCTT 2 /E /D mis11Minor allele frequency- A:0.50CSA 4

    HapMap Linkage Disequilibrium report for ACP2 (47260853 - 47270457 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACP2: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACP2 for disorders           About GeneDecksing

    OMIM gene information: 171650   
    OMIM disorders: 200950  
    UniProtKB/Swiss-Prot: PPAL_HUMAN, P11117
  • Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD) [MIM:200950]. The clinical features are
  • intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal
    acid phosphatase is deficient in cultured fibroblasts and multiple tissues

    9 diseases for ACP2:    About MalaCards
    lysosomal acid phosphatase deficiency    supranuclear palsy    progressive supranuclear palsy    keratoconus
    alcoholism    metabolic disorders    seminoma    hypotonia
    prostatitis

    2 Novoseek disease relationships for ACP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysosomal acid phosphatase 97.4 13 8509395 (1), 9746610 (1), 11801736 (1), 2209556 (1) (see all 12)
    keratoconus 54.3 2 11481261 (1), 16431954 (1)

    Genatlas disease: ACP2
    phosphatase acid,deficiency

    Human Genome Epidemiology (HuGE) Navigator: ACP2 (2 documents)

    Export disorders for ACP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACP2 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with ACP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Structure of the human lysosomal acid phosphatase gene. (PubMed id 2776754)1, 2 Geier C.... Pohlmann R. (1989)
    3. Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment. (PubMed id 3191910)1, 2 Pohlmann R.... von Figura K. (1988)
    4. Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11. (PubMed id 975882)1, 3 Shows T.B....Lalley P.A. (1976)
    5. Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder. (PubMed id 5410815)1, 2 Nadler H.L. and Egan T.J. (1970)
    6. The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes. (PubMed id 11801736)1, 9 Obermuller S....Honing S. (2002)
    7. Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms. (PubMed id 17357082)1, 9 Melquist S....Stephan D.A. (2007)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53 HGNC: 123 AceView: ACP2 Ensembl:ENSG00000134575 euGenes: HUgn53
    ECgene: ACP2 Kegg: 53 H-InvDB: ACP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACP2 gene:
    Search GeneIP for patents involving ACP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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