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Aliases for ACP1 Gene

Aliases for ACP1 Gene

  • Acid Phosphatase 1, Soluble 2 3
  • Low Molecular Weight Cytosolic Acid Phosphatase 3 4
  • Red Cell Acid Phosphatase 1 3 4
  • Adipocyte Acid Phosphatase 3 4
  • LMW-PTPase 3 4
  • LMW-PTP 3 4
  • Low Molecular Weight Phosphotyrosine Protein Phosphatase 3
  • Cytoplasmic Phosphotyrosyl Protein Phosphatase 3
  • Acid Phosphatase Of Erythrocyte 3
  • Protein Tyrosine Phosphatase 3
  • EC 3.1.3.48 4
  • EC 3.1.3.2 4
  • HAAP 3

External Ids for ACP1 Gene

Summaries for ACP1 Gene

Entrez Gene Summary for ACP1 Gene

  • The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for ACP1 Gene

ACP1 (Acid Phosphatase 1, Soluble) is a Protein Coding gene. Diseases associated with ACP1 include okamoto syndrome and bubonic plague. Among its related pathways are PDGFR-beta signaling pathway and Adherens junction. GO annotations related to this gene include SH3 domain binding and non-membrane spanning protein tyrosine phosphatase activity.

UniProtKB/Swiss-Prot for ACP1 Gene

  • Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity

Gene Wiki entry for ACP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACP1 Gene

Genomics for ACP1 Gene

Genomic Location for ACP1 Gene

Start:
264,140 bp from pter
End:
278,283 bp from pter
Size:
14,144 bases
Orientation:
Plus strand

Genomic View for ACP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACP1 Gene

Regulatory Elements for ACP1 Gene

Proteins for ACP1 Gene

  • Protein details for ACP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24666-PPAC_HUMAN
    Recommended name:
    Low molecular weight phosphotyrosine protein phosphatase
    Protein Accession:
    P24666
    Secondary Accessions:
    • A8K1L9
    • B5MCC7
    • P24667
    • Q16035
    • Q16036
    • Q16725
    • Q3KQX8
    • Q53RU0

    Protein attributes for ACP1 Gene

    Size:
    158 amino acids
    Molecular mass:
    18042 Da
    Quaternary structure:
    • Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoforms 2 or 3. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1.

    Three dimensional structures from OCA and Proteopedia for ACP1 Gene

    Alternative splice isoforms for ACP1 Gene

neXtProt entry for ACP1 Gene

Proteomics data for ACP1 Gene at MOPED

Post-translational modifications for ACP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys113

No data available for DME Specific Peptides for ACP1 Gene

Domains for ACP1 Gene

Gene Families for ACP1 Gene

HGNC:
  • PTP2 :Protein tyrosine phosphatases / Class II Cys-based PTPs

UniProtKB/Swiss-Prot:

PPAC_HUMAN
Family:
  • Belongs to the low molecular weight phosphotyrosine protein phosphatase family.:
    • P24666
genes like me logo Genes that share domains with ACP1: view

Function for ACP1 Gene

Molecular function for ACP1 Gene

GENATLAS Biochemistry: phosphatase acid,red cell
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: A phosphate monoester + H(2)O = an alcohol + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by sulfhydryl reagents
UniProtKB/Swiss-Prot Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity

Enzyme Numbers (IUBMB) for ACP1 Gene

Gene Ontology (GO) - Molecular Function for ACP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity --
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 15846844
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with ACP1: view

Phenotypes for ACP1 Gene

genes like me logo Genes that share phenotypes with ACP1: view

Animal Models for ACP1 Gene

MGI Knock Outs for ACP1:

miRNA for ACP1 Gene

miRTarBase miRNAs that target ACP1

No data available for Transcription Factor Targeting and HOMER Transcription for ACP1 Gene

Localization for ACP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACP1 Gene COMPARTMENTS Subcellular localization image for ACP1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ACP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10940933
GO:0009898 cytoplasmic side of plasma membrane IDA 10940933
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ACP1: view

Pathways for ACP1 Gene

genes like me logo Genes that share pathways with ACP1: view

Pathways by source for ACP1 Gene

2 BioSystems pathways for ACP1 Gene
2 KEGG pathways for ACP1 Gene

Gene Ontology (GO) - Biological Process for ACP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with ACP1: view

Compounds for ACP1 Gene

(6) HMDB Compounds for ACP1 Gene

Compound Synonyms Cas Number PubMed IDs
4-Nitrophenol
  • 1-Hydroxy-4-nitrobenzene
100-02-7
Flavin Mononucleotide
  • FMN
146-17-8
Phosphate
  • NFB Orthophosphate
14265-44-2
Riboflavin
  • (-)-Riboflavin
83-88-5
Tartaric acid
  • (+)-(2R,3R)-Tartaric acid
87-69-4

(2) Drugbank Compounds for ACP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4-Nitrophenyl Phosphate
330-13-2 target
Adenine
  • 1H-Purin-6-amine
73-24-5 target

(116) Novoseek inferred chemical compound relationships for ACP1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 94.6 339
phosphotyrosine 91.9 118
sodium orthovanadate 88.7 68
vanadate 88.1 114
phenylarsine oxide 82.6 35
genes like me logo Genes that share compounds with ACP1: view

Transcripts for ACP1 Gene

Unigene Clusters for ACP1 Gene

Acid phosphatase 1, soluble:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -

Relevant External Links for ACP1 Gene

GeneLoc Exon Structure for
ACP1
ECgene alternative splicing isoforms for
ACP1

Expression for ACP1 Gene

mRNA expression in normal human tissues for ACP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACP1 Gene

SOURCE GeneReport for Unigene cluster for ACP1 Gene Hs.558296

mRNA Expression by UniProt/SwissProt for ACP1 Gene

P24666-PPAC_HUMAN
Tissue specificity: T-lymphocytes express only isoform 2.
genes like me logo Genes that share expressions with ACP1: view

Orthologs for ACP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACP1 36
  • 100 (n)
  • 100 (a)
ACP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACP1 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACP1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acp1 36
  • 84.81 (n)
  • 86.08 (a)
Acp1 16
Acp1 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ACP1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565965 36
  • 82.91 (n)
  • 80.38 (a)
chicken
(Gallus gallus)
Aves ACP1 36
  • 78.48 (n)
  • 82.28 (a)
ACP1 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACP1 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5878 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10863 36
zebrafish
(Danio rerio)
Actinopterygii acp1 36
  • 69.44 (n)
  • 75.64 (a)
acp1 37
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004079 36
  • 55.63 (n)
  • 52.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14297 37
  • 19 (a)
OneToMany
CG31469 37
  • 30 (a)
OneToMany
primo-1 36
  • 52.48 (n)
  • 47.3 (a)
primo-1 37
  • 45 (a)
OneToMany
primo-2 37
  • 42 (a)
OneToMany
primo-1 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea Y94H6A.7 36
  • 50.43 (n)
  • 47.44 (a)
Y94H6A.7 37
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LTP1 37
  • 32 (a)
OneToOne
LTP1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToOne
Species with no ortholog for ACP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACP1 Gene

ENSEMBL:
Gene Tree for ACP1 (if available)
TreeFam:
Gene Tree for ACP1 (if available)

Paralogs for ACP1 Gene

genes like me logo Genes that share paralogs with ACP1: view

No data available for Paralogs for ACP1 Gene

Variants for ACP1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ACP1 Gene

P24666-PPAC_HUMAN
ACP1 is genetically polymorphic. Three common alleles are known in Caucasians: ACP1*A, ACP1*B and ACP1*C. They give rise to six different phenotypes. Each allele appears to encode two electrophoretically different isozymes, F and S, which are produced in allele-specific ratios. The sequence shown is that of allele ACP1*B and allele ACP1*C

Sequence variations from dbSNP and Humsavar for ACP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6855 -- 277,995(+) GAAAG(A/G)AGGAC utr-variant-3-prime, nc-transcript-variant
rs12503 -- 277,951(+) GCTCC(A/C)ATCTG utr-variant-3-prime, nc-transcript-variant
rs14814 -- 278,000(+) AAGGA(A/C)ACTTG utr-variant-3-prime, nc-transcript-variant
rs1130612 -- 272,048(+) GTAGA(C/T)AGCGC reference, synonymous-codon, intron-variant, nc-transcript-variant
rs1130613 -- 272,058(+) CGGCA(A/G)CTTCC reference, missense, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ACP1 Gene

Variant ID Type Subtype PubMed ID
nsv873529 CNV Gain 21882294
nsv833159 CNV Loss 17160897
essv2780 CNV CNV 17122850
dgv1137e1 CNV Complex 17122850
nsv873530 CNV Gain 21882294
nsv873531 CNV Gain 21882294
essv3569 CNV CNV 17122850
nsv833170 CNV Loss 17160897

Relevant External Links for ACP1 Gene

HapMap Linkage Disequilibrium report
ACP1

Disorders for ACP1 Gene

(2) University of Copenhagen DISEASES for ACP1 Gene

(90) Novoseek inferred disease relationships for ACP1 Gene

Disease -log(P) Hits PubMed IDs
noonan syndrome 70 11
bubonic plague 60.8 5
centronuclear myopathy 49.8 2
lafora disease 45 5
insulin resistance 40.4 26

Relevant External Links for ACP1

Genetic Association Database (GAD)
ACP1
Human Genome Epidemiology (HuGE) Navigator
ACP1
genes like me logo Genes that share disorders with ACP1: view

No data available for UniProtKB/Swiss-Prot for ACP1 Gene

Publications for ACP1 Gene

  1. Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase. (PMID: 1304913) Shekels L.L. … Bernlohr D.A. (Protein Sci. 1992) 3 4 23
  2. Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. (PMID: 9705307) Zhang M. … van Etten R.L. (J. Biol. Chem. 1998) 3 4 23
  3. The genetics of signal transduction and the effect of smoking on intrauterine growth. (PMID: 11369750) Bottini E. … Lucarini N. (Int J Epidemiol 2001) 3 23 49
  4. Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. (PMID: 12640337) Meloni G. … Bottini E. (Med. Sci. Monit. 2003) 3 23 49
  5. Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex. (PMID: 15586390) Bottini N. … Bottini E. (Diabetes Metab. Res. Rev. 2005) 3 23 49

Products for ACP1 Gene

Sources for ACP1 Gene

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