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ACP1 Gene

protein-coding   GIFtS: 69

GC02P000254
acid phosphatase 1, soluble
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
EC 3.1.3.48,EC 3.1.3.2 3
HAAP 2
LMW-PTP 3
LMW-PTPase 3
MGC111030 2
MGC3499 2
Descriptions
Adipocyte acid phosphatase 2, 3
Low molecular weight cytosolic acid phosphatase 3
Red cell acid phosphatase 1 2, 3
acid phosphatase 1, soluble 2
acid phosphatase of erythrocyte 2
cytoplasmic phosphotyrosyl protein phosphatase 2
low molecular weight phosphotyrosine protein phosphatase 2
protein tyrosine phosphatase 2
External Ids
HGNC: 1221
Entrez Gene: 522
UniProtKB: P246663
Ensembl: ENSG000001437277
Search outside databases for aliases for ACP1 gene

Previous GC identifer: GC02P000258

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACP1:
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It
functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein
tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes
orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic,
and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each
allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are
produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding
distinct isoforms have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and
synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity

Gene Wiki entry for ACP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ACP1 gene  

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25

ACP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P000254:     (about GC identifiers)

Start:
254,872 bp from pter
End:
268,283 bp from pter
Size:
13,412 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022327.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666 (See protein sequence)
Recommended Name: Low molecular weight phosphotyrosine protein phosphatase  
Size: 158 amino acids; 18042 Da
Subunit: Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for
isoforms 2 or 3
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
1XWW (3D)    5PNT (3D)    
Secondary accessions: P24667 Q16035 Q16036 Q16725 Q3KQX8 Q53RU0
Alternative splicing: 3 isoforms:  P24666-1   P24666-2, P24667-1   P24666-3   (The ratio of isoform 1 to isoform 2 is 2:1 in allele A, 4:1 in allele B and 1:4 in allele C)

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001035739.1  NP_004291.1  NP_009030.1  


    ENSEMBL proteins: 
    ENSP00000272066 ENSP00000384184 ENSP00000385404 ENSP00000384307 ENSP00000272065 ENSP00000272067 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant ACP1 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Acid Phosphatase, Acid phosphatase)
    Human Recombinant Proteins from Abnova (ACP1)
                   OriGene Purified Recombinant Human Proteins (see all 2): ACP1  

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625 soluble fraction TAS1587862
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for ACP1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ACP1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Acid Phosphatase, Acid phosphatase), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ACP1)
    Novus Biologicals Antibodies for ACP1

    Assays for ACP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR000106 Tyr_phospatase/Ars_reductase
     IPR002115 Tyr_Pase_low_mol_wt_mml
     IPR017867 Tyr_phospatase_low_mol_wt


       GeneDecks  ACP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P24666

    ProtoNet protein and cluster: P24666

    2 Blocks protein families:
    IPB000106 LMW phosphotyrosine protein phosphatase signature
    IPB002115 Mammalian LMW phosphotyrosine protein phosphatase signature


    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACP1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_004300

                  Applied Biosystems Silencer® siRNAs for ACP1

                  Sigma-Aldrich siRNA and siRNA Panels for ACP1  
                         Sigma-Aldrich shRNA Panels and shRNA for ACP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ACP1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040649
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040649
                                     untagged cDNA clones in CMV expression vector (see all 7): BC020699 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_007099

    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and
    synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate
    Enzyme regulation: Inhibited by sulfhydryl reagents
    Enzyme Number (IUBMB): EC 3.1.3.48,EC 

    Genatlas biochemistry entry for ACP1:
    phosphatase acid,red cell

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003993 acid phosphatase activity TAS1587862
    GO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA--
    GO:0016787 hydrolase activity IEA--
    GO:0042802 identical protein binding IPI17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    3 Invitrogen iPath™ Online BioAtlas - Pathways for ACP1 (Maps provided by GeneGo):
     dGTP/GTP/XTP metabolism
     dATP/dITP metabolism
     ATP/ITP metabolism

       GeneDecks  ACP1 for the pathways selected above  
    About GeneDecksing

    3 Sigma-Aldrich "Your Favorite Gene" Pathways for  ACP1  (Your Favorite Gene powered by Ingenuity) 
     PDGF Signaling
     Ephrin Receptor Signaling
     Riboflavin Metabolism

       GeneDecks  ACP1 for the pathways selected above  
    About GeneDecksing

    3 Kegg Pathways  (Kegg details for ACP1):
     hsa00361 gamma-Hexachlorocyclohexane degradation
     hsa00740 Riboflavin metabolism
     hsa04520 Adherens junction

       GeneDecks  ACP1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ACP1 


    5/37 Interacting proteins for ACP1 (ENSP000002720673 P246661) via UniProtKB, MINT, and/or STRING (see all 37 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACP1P246661EBI-717701, EBI-717701
    ACP2ENSP000002569973STRING (score=.98)
    EPHA2ENSP000003512093STRING (score=.96)
    ACPPENSP000003230363STRING (score=.951)
    ACP6ENSP000003582413STRING (score=.945)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470 protein amino acid dephosphorylation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ACP1
    10/36 Novoseek chemical compound relationships for ACP1 gene (see all 36 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 94.57 3400 16039061 (12), 15477998 (6), 10980198 (5), 8258363 (5) (see all 99)
    phosphotyrosine 92.06 208 7679612 (5), 2134890 (3), 8620937 (3), 7686722 (3) (see all 99)
    sodium orthovanadate 88.57 74 10230815 (2), 11507066 (2), 8186375 (1), 8014198 (1) (see all 63)
    vanadate 88.28 138 11980490 (4), 2154464 (3), 9878539 (2), 10439081 (2) (see all 99)
    raytide 80.64 5 1318316 (1), 7684610 (1), 8256510 (1)
    p-nitrophenyl phosphate 77.13 7 8127855 (2), 2134890 (1), 7528537 (1), 7589546 (1) (see all 6)
    dephostatin 73.95 8 8557604 (4), 8226312 (1)
    bpv(phen) 71.60 3 16039061 (1), 11792460 (1)
    benzylphosphonic acid 70.50 2 9458714 (1), 9106619 (1)
    cl 100 68.49 8 7780739 (2), 8106404 (2), 8390041 (1), 7806236 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACP1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_004300

                  Sigma-Aldrich siRNA and siRNA Panels for ACP1  
                         Sigma-Aldrich shRNA Panels and shRNA for ACP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001040649  NM_004300  NM_007099  

    REFSEQ mRNAs for ACP1 gene (3 alternative transcripts): 

    NM_001040649.2   NM_004300.3   NM_007099.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001040649  NM_004300  NM_007099  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040649
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040649
                                     untagged cDNA clones in CMV expression vector (see all 7): BC020699 

    Additional cDNA sequence: 

    AB209838.1 AK289934.1 AK291861.1 BC007422.2 BC106011.1 BT007136.1 CR591454.1 CR597555.1 
    CR599434.1 CR607431.1 CR609595.1 CR609802.1 CR613475.1 CR624312.1 M83653.1 M83654.1 
    M87545.1 S62884.1 Y16846.1 

    20 DOTS entries:

    DT.100842980  DT.99931855  DT.100030203  DT.454219  DT.100842972  DT.100842978  DT.119141  DT.121013711 
    DT.100742580  DT.100842976  DT.95256266  DT.100842982  DT.119140  DT.95256302  DT.121013776  DT.121013819 
    DT.91759792  DT.95256278  DT.121417499  DT.99984839 

    24/473 AceView cDNA sequences (see all 473 ):

    CD251736 CR599434 NM_004300 CR609595 BM477153 CR597555 BM970524 AW769370 
    BM770461 CD675878 AA568474 BM460072 CD673215 BU539875 BE905801 BM793724 
    NM_007099 BF726270 BM825165 BE618323 AI056981 BG056276 AI167367 AL573837 

    highest scoring ESTs for ACP1:

    AA037447 AA037448 AA056583 AA115242 AA130244 AA130248 AA205145 AA467733 AA467801 AA479138 

    Unigene Cluster for ACP1:

    Acid phosphatase 1, soluble
    Hs.558296  [show with all ESTs]
    Unigene Representative Sequence: NM_004300


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACP1 (see all 9 )

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
    SP1:                                -                 -                 -     -     -                                                         
    SP2:                                -     -           -           -     -           -                                                         
    SP3:                                -     -           -     -     -     -           -                                                         
    SP4:                                -     -           -                 -     -     -                                                         
    SP5:                                      -           -                 -     -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for ACP1

    6 Ensembl transcripts including schematic representations:
    ENST00000272066  ENST00000405364  ENST00000407983  ENST00000405233  ENST00000272065  ENST00000272067  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ACP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ACP1

    1 / 2 / 3

    8 probe-sets matching ACP1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    36611_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U25849 0.20 1.00 0.72 1

    201630_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004300 0.60 1.00 0.82 1

    201629_s_at2, 3 U133-A 2 1.00 0.91 -- -- BE872974 0.80 1.00 0.91 1

    215227_x_at2, 3 U133-A 2 0.91 0.95 -- -- BG035989 0.80 1.00 0.91 1

    1554808_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    201630_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    201629_s_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --

    215227_x_at2 U133Plus2 2 0.91 0.95 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATATTTCAA

    SOURCE GeneReport for Unigene cluster: Hs.558296

    Expression variation in blood from EXPOLDB for ACP1

    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Tissue specificity: T-lymphocytes express only isoform 2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ACP1 gene from 5/18 species (see all 18 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ACP11   -- acid phosphatase 1, soluble 100(n)
    100(a)
    458990  XM_001149653.1  XP_001149653.1 
    cow
    (Bos taurus)
    ACP11   -- acid phosphatase 1, soluble 91.03(n)
    94.87(a)
    280977  NM_173978.2  NP_776403.1 
    rat
    (Rattus norvegicus)
    Acp11   -- acid phosphatase 1, soluble 79.54(n)
    81.01(a)
    24161  NM_021262.2  NP_067085.1 
    mouse
    (Mus musculus)
    Acp11, 5 125
    acid phosphatase 1, soluble1, 5 80.17(n)1
    81.01(a)1
    114311  NM_021330.31  NP_067305.21 
     AA0001995  AI4274685  (see all 33)
    chicken
    (Gallus gallus)
    ACP11   -- acid phosphatase 1, soluble 72.36(n)
    74.05(a)
    421909  NM_001039291.1  NP_001034380.1 
    About this table        Species with no ortholog for ACP1

    ENSEMBL Gene Tree for ACP1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Pseudogenes
    3 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Polymorphism: ACP1 is genetically polymorphic. Three common alleles are known in Caucasians:
    ACP1*A, ACP1*B and ACP1*C. They give rise to six different phenotypes. Each allele appears to
    encode two electrophoretically different isozymes, F and S, which are produced in allele-specific
    ratios. The sequence shown is that of allele ACP1*B and allele ACP1*C


    10/95 NCBI SNPs in ACP1 are shown (see all 95 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 49)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs68551,2
    A,C,F,H267995(+) GAAAGA/GAGGAC 2 -- ut31 trp313Minor allele frequency- G:0.14MN EU EA WA 1442
    rs127144021,2
    A,C,F,H262926(+) TCTTCG/ATTGGT 3 -- ng31 int18Minor allele frequency- A:0.31EU EA WA NA 632
    --
    rs127144011,2
    A,C,F,H262840(+) ATTATA/GAATTA 3 -- int1 ng314Minor allele frequency- G:0.33EU EA WA 412
    rs111274661,2
    A,C,F,H268752(+) ACCCAG/CTGAGT 2 -- ng3113Minor allele frequency- C:0.37NA EU EA WA 1152
    rs76059241,2
    F,H262626(+) TCATCC/GTGCTG 3 -- int1 ng314Minor allele frequency- G:0.01EU EA WA 416
    rs115537461,2
    C,F262203(+) ATTGAC/TAGCGG 3 D/D T/I syn1 mis1 int15Minor allele frequency- T:0.24NA EU EA WA 496
    rs355691981,2
    C,F267237(-) AGTCAG/AAGTCA 2 F/S mis15Minor allele frequency- A:0.01NA EU EA WA 494
    rs125031,2
    H267951(+) GCTCCC/AATCTG 2 -- ut31 ese35Minor allele frequency- A:0.00MN EU EA WA 598
    rs30207741,2
    H262471(+) GAAAGA/GCTTGC 3 -- int1 ut314Minor allele frequency- G:0.00EU EA WA 420
    rs115537421,2
    C,F262051(+) GACAGC/TGCGGC 3 S/S syn1 int1 ese33Minor allele frequency- T:0.01NA 138
    About this table

    HapMap Linkage Disequilibrium images for ACP1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 171500

    10/90 Novoseek disease relationships for ACP1 gene (see all 90 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    noonan syndrome 69.18 10 15240615 (2), 12161469 (2), 16208280 (1), 19407499 (1) (see all 8)
    bubonic plague 61.79 7 1723471 (1), 14609321 (1), 8052312 (1), 7803389 (1) (see all 5)
    myotubular myopathy 51.08 2 10900271 (1), 11056007 (1)
    lafora disease 46.82 6 9771710 (1), 16134145 (1), 14643920 (1), 17010495 (1) (see all 5)
    insulin resistance 39.92 32 18925540 (4), 15271787 (2), 7769120 (2), 7535776 (1) (see all 21)
    leopard syndrome 38.27 1 16208280 (1)
    favism 36.02 2 8522318 (1), 9116311 (1)
    autoimmunity 34.39 6 17608818 (1), 11826758 (1), 18303998 (1), 18416318 (1) (see all 6)
    immune disorder 30.31 1 18490013 (1)
    autoimmune diseases 27.54 10 17868256 (1), 10885457 (1), 18056891 (1), 16163373 (1) (see all 10)
    About this table

    Genetic Association Database: ACP1
    Human Genome Epidemiology Navigator: ACP1 (29 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/1298 PubMed articles for ACP1 gene (see all 1298 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 52 HGNC: 122 AceView: ACP1 Ensembl:ENSG00000143727 euGenes: HUgn52
    ECgene: ACP1 H-InvDB: ACP1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ACP1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ACP1:
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      Free SNP selection tool



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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ACP1-related products

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     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ACP1

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

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