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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACP1 Gene

protein-coding   GIFtS: 69
GCID: GC02P000254

acid phosphatase 1, soluble

 Explore 132 diseases affiliated with
ACP1 via our new
 Human Malady Compendium 
Biological research products
for ACP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Acid Phosphatase 1, Soluble1 2     Acid Phosphatase Of Erythrocyte2
Adipocyte Acid Phosphatase2 3     Cytoplasmic Phosphotyrosyl Protein Phosphatase2
Low Molecular Weight Cytosolic Acid Phosphatase2 3     Low Molecular Weight Phosphotyrosine Protein Phosphatase2
Red Cell Acid Phosphatase 12 3     Protein Tyrosine Phosphatase2
LMW-PTP2 3     EC 3.1.3.23
LMW-PTPase2 3     EC 3.1.3.483
HAAP2     

External Ids:    HGNC: 1221   Entrez Gene: 522   Ensembl: ENSG000001437277   OMIM: 1715005   UniProtKB: P246663   
ORGUL members:         
NONCODE:n406571    

Export aliases for ACP1 gene to outside databases

Previous GC identifer: GC02P000258


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACP1:
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid
phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and
orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is
genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes.
Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in
allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been
identified for this gene. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
Isoform 3 does not possess phosphatase activity

Gene Wiki entry for ACP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022221.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACP1 gene promoter:
         STAT5B   p53   Pax-2   STAT3   Pax-2a   Meis-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25

ACP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P000254:  view genomic region     (about GC identifiers)

Start:
264,140 bp from pter      End:
278,283 bp from pter
Size:
14,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666 (See protein sequence)
Recommended Name: Low molecular weight phosphotyrosine protein phosphatase  
Size: 158 amino acids; 18042 Da
Subunit: Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoforms 2 or 3.
Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for ACP1:
1XWW (3D)        3N8I (3D)        5PNT (3D)    
Secondary accessions: A8K1L9 P24667 Q16035 Q16036 Q16725 Q3KQX8 Q53RU0
Alternative splicing: 3 isoforms:  P24666-1   P24666-2, P24667-1   P24666-3   

Explore the universe of human proteins at neXtProt for ACP1: NX_P24666

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P24666

  • ACP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035739.1  NP_004291.1  NP_009030.1  

    ENSEMBL proteins: 
     ENSP00000272067   ENSP00000272065   ENSP00000410331   ENSP00000385404   ENSP00000389681  
     ENSP00000408596   ENSP00000384184   ENSP00000384307   ENSP00000411121  

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    Uscn Proteins for ACP1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0009898internal side of plasma membrane IDA10940933
    GO:0019717synaptosome ----


    ACP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ACP1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACP1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000106 Tyr_phospatase/Ars_reductase
     IPR002115 Tyr_Pase_low_mol_wt_mml
     IPR023485 Ptyr_pPase_SF
     IPR017867 Tyr_phospatase_low_mol_wt

    Graphical View of Domain Structure for InterPro Entry P24666

    ProtoNet protein and cluster: P24666

    2 Blocks protein families:
    IPB000106 LMW phosphotyrosine protein phosphatase signature
    IPB002115 Mammalian LMW phosphotyrosine protein phosphatase signature


    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
    Isoform 3 does not possess phosphatase activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate
    Enzyme regulation: Inhibited by sulfhydryl reagents

         Genatlas biochemistry entry for ACP1:
    phosphatase acid,red cell

    Enzyme Numbers (IUBMB): EC 3.1.3.481 EC 3.1.3.21

    miRNA
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    hsa-miR-29a*
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    Inhib. RNA
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003993acid phosphatase activity IEA--
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI9499402
    GO:0016791phosphatase activity ----


    ACP1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Acp1tm1Lex for ACP1
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acp1):
     cellular  growth/size  immune system 

    ACP1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1EPHA2 forward signaling
    EPHA2 forward signaling1.00
    2Adherens junction
    Adherens junction1.00
    3Riboflavin metabolism
    Riboflavin metabolism1.00
    4PDGFR-beta signaling pathway
    PDGFR-beta signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for ACP1 
        EPHA2 forward signaling
    PDGFR-beta signaling pathway


    2         Kegg Pathways  (Kegg details for ACP1):
        Riboflavin metabolism
    Adherens junction


    ACP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for ACP1 (P246661, 3 ENSP000002720654) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP1LQ5T0N53, ENSP000002712344I2D: score=4 STRING: ENSP00000271234
    EPHB1P547623, ENSP000003810974I2D: score=3 STRING: ENSP00000381097
    EPHA2P293173, ENSP000003512094I2D: score=2 STRING: ENSP00000351209
    ZAP70P434033, ENSP000002649724I2D: score=2 STRING: ENSP00000264972
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission IEA--
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation ----


    ACP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACP1

    6 HMDB Compounds for ACP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Riboflavin(-)-Riboflavin (see all 30)83-88-5--
    Tartaric acid(+)-(2R,3R)-Tartaric acid (see all 37)87-69-4--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for ACP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenine1H-Purin-6-amine (see all 5)73-24-5target--10684601 17139284 17016423 7629177 15358193 10592235
    4-Nitrophenyl Phosphate-- 330-13-2target--10592235

    10/116 Novoseek chemical compound relationships for ACP1 gene (see all 116)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 94.6 3576 16039061 (12), 15477998 (6), 10980198 (5), 8258363 (5) (see all 99)
    phosphotyrosine 91.9 211 7679612 (5), 2134890 (3), 8620937 (3), 7686722 (3) (see all 99)
    sodium orthovanadate 88.7 78 10230815 (2), 11507066 (2), 8186375 (1), 8014198 (1) (see all 66)
    vanadate 88.1 139 11980490 (4), 2154464 (3), 9878539 (2), 10439081 (2) (see all 99)
    phenylarsine oxide 82.6 54 8581996 (2), 7738000 (2), 1423640 (2), 9341756 (2) (see all 31)
    raytide 80.3 5 1318316 (1), 7684610 (1), 8256510 (1)
    p-nitrophenyl phosphate 76.9 8 8127855 (2), 2134890 (1), 19414171 (1), 7528537 (1) (see all 7)
    dephostatin 75.7 9 8557604 (4), 8226312 (1), 20130847 (1)
    bpv(phen) 71.2 3 16039061 (1), 11792460 (1)
    benzylphosphonic acid 70 2 9458714 (1), 9106619 (1)

    Search CenterWatch for drugs/clinical trials and news about ACP1 / PPAC 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACP1 gene (4 alternative transcripts): 
    NM_001040649.2  NM_004300.3  NM_007099.3  NM_177554.1  

    Unigene Cluster for ACP1:

    Acid phosphatase 1, soluble
    Hs.558296  [show with all ESTs]
    Unigene Representative Sequence: NR_024080
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484125 ENST00000272067(uc002qwg.3 uc002qwh.3) ENST00000272065(uc002qwf.3)
    ENST00000413140 ENST00000407983(uc002qwd.2) ENST00000442386 ENST00000439645
    ENST00000405364 ENST00000405233(uc002qwe.4) ENST00000480874 ENST00000453390
    ENST00000484464 ENST00000463831

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    Additional cDNA sequence: 

    AB209838.1 AK289934.1 AK291861.1 BC007422.2 BC106011.1 BT007136.1 M83653.1 M83654.1 
    M87545.1 NR_024080.1 S62884.1 Y16846.1 

    20 DOTS entries:

    DT.100842980  DT.99931855  DT.100030203  DT.454219  DT.100842972  DT.100842978  DT.100742580  DT.121013711 
    DT.119141  DT.95256266  DT.100842976  DT.100842982  DT.119140  DT.95256302  DT.121013776  DT.121013819 
    DT.91759792  DT.95256278  DT.121417499  DT.99984839 

    24/473 AceView cDNA sequences (see all 473):

    BM477153 CR609595 CB162252 AL552042 BP872697 BM667352 BQ226796 AI141163 
    CR607431 BM716010 BM770461 AI168086 BG056276 BE905801 AL573837 AI167367 
    N90219 BM825165 BM793724 AI056981 BE618323 AW951882 AI870895 R29518 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACP1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
    SP1:                                -                 -                 -     -     -                                                         
    SP2:                                -     -           -           -     -           -                                                         
    SP3:                                -     -           -     -     -     -           -                                                         
    SP4:                                -     -           -                 -     -     -                                                         
    SP5:                                      -           -                 -     -     -                                                         


    ECgene alternative splicing isoforms for ACP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATATTTCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ACP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ACP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACP1

    SOURCE GeneReport for Unigene cluster: Hs.558296

    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Tissue specificity: T-lymphocytes express only isoform 2

        SABiosciences Expression via Pathway-Focused PCR Array including ACP1: 
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ACP1 gene from 10/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acp11 , 5 acid phosphatase 1, soluble1, 5 87.97(n)1
    89.24(a)1
      12 (13.00 cM)5
    114311  NM_001110239.11  NP_001103709.11 
     308933265 
    chicken
    (Gallus gallus)
    Aves PPAC_CHICK6
    Low molecular weight phosphotyrosine protein phosp...
    73(a)
    1 ↔ 1
    3(94770314-94791110)
    lizard
    (Anolis carolinensis)
    Reptilia ACP16
    --
    67(a)
    1 ↔ 1
    1(160092160-160097628)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY039214.12   -- 77.5(n)    AY039214.1 
    zebrafish
    (Danio rerio)
    Actinopterygii acp11 acid phosphatase 1, soluble 66.24(n)
    72.44(a)
      541489  NM_001014302.1  NP_001014324.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta primo-11 , 3 protein amino acid dephosphorylation protein
    tyrosine more3
    CG33748-PA1
    46(a)3
    50(n)1
    47.3(a)1
      37721791  NM_001032017.11  NP_001027188.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y94H6A.76
    --
    42(a)
    1 ↔ 1
    IV(2714027-2716569)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G446206
    protein-tyrosine phosphatase
    23(a)
    1 ↔ 1
    3(16193829-16195833)
    rice
    (Oryza sativa)
    Liliopsida --
    low molecular weight protein-tyrosine-phosphatase ...
    22(a)
    1 ↔ 1
    8(27886181-27890324)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria etp6
    wzb6
    protein-tyrosine phosphatase
    30(a)
    28(a)
    many → 1
    many → 1
    Chromosome(1043453-1043899)
    Chromosome(2133679-2134122)


    ENSEMBL Gene Tree for ACP1 (if available)
    TreeFam Gene Tree for ACP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACP1 gene

    ACP1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for ACP1 (see all 6)
    PGOHUM00000238865 PGOHUM00000248729 PGOHUM00000248738 PGOHUM00000249002 PGOHUM00000244482


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Polymorphism: ACP1 is genetically polymorphic. Three common alleles are known in Caucasians: ACP1*A, ACP1*B and ACP1*C.
    They give rise to six different phenotypes. Each allele appears to encode two electrophoretically different isozymes,
    F and S, which are produced in allele-specific ratios. The sequence shown is that of allele ACP1*B and allele ACP1*C


    10/299 NCBI SNPs in ACP1 are shown (see all 299    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797160741,2
    C,F,non-pathogenic273567(+) TAATCA/GAGTTA 5 Q R mis18Minor allele frequency- G:0.28WA NA CSA EA EU 5359
    rs747379561,2
    F,--259446(+) GTTTTA/CCAGAA 4 -- us2k11Minor allele frequency- C:0.10WA 118
    rs607108661,2
    --260932(+) AACTCG/TAACGA 4 -- us2k10--------
    rs1113413441,2
    C,--261441(+) GCAGGC/AGCGCG 4 -- ut51 nc-transcript-variant2Minor allele frequency- A:0.04WA 120
    rs75885151,2
    C,F,H,--261666(+) CATGAG/AGGGGA 4 -- int1 trp39Minor allele frequency- A:0.06NS EA NA 1324
    rs575626991,2
    C--261771(+) TAAACG/CTGGGT 4 -- int11Minor allele frequency- C:0.50WA 2
    rs30207661,2
    --261803(+) CCGGGC/G/TCTCTT 4 -- int10--------
    rs798513951,2
    C,--262440(+) TTGTTG/CGGTAG 4 -- int11Minor allele frequency- C:0.50NA 2
    rs1879724981,2
    --262986(+) AACCTC/TCAACA 6 -- us2k1 int10--------
    rs1911422431,2
    --263149(+) TAAAAA/CCACCT 6 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for ACP1 (264140 - 278283 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ACP1
         2 CNVs: 2360 3341

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACP1
    DNA2.0 Custom Variant and Variant Library Synthesis for ACP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACP1 for disorders           About GeneDecksing

    OMIM gene information: 171500    OMIM disorders: --

    20/132 diseases for ACP1 (see all 132):    About MalaCards
    bubonic plague    multiple symmetrical lipomatosis    multiple symmetric lipomatosis    diffuse large b-cell lymphoma
    guillain-barre syndrome    familial adenomatous polyposis    alcoholism    polycythemia vera
    centronuclear myopathy    adenomatous polyposis coli    favism    myoclonus epilepsy
    b-cell lymphomas    progressive myoclonus epilepsy    leopard syndrome    plague
    lafora disease    okamoto syndrome    type 2 diabetes mellitus    diabetes mellitus

    3 diseases from the University of Copenhagen DISEASES database for ACP1:
    Favism     Arthropathy     Multiple symmetric lipomatosis

    10/90 Novoseek disease relationships for ACP1 gene (see all 90)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noonan syndrome 70 11 15240615 (2), 12161469 (2), 16208280 (1), 19541608 (1) (see all 9)
    bubonic plague 60.8 7 1723471 (1), 14609321 (1), 8052312 (1), 7803389 (1) (see all 5)
    centronuclear myopathy 49.8 2 10900271 (1), 11056007 (1)
    lafora disease 45 6 9771710 (1), 16134145 (1), 14643920 (1), 17010495 (1) (see all 5)
    insulin resistance 40.4 32 18925540 (4), 15271787 (2), 7769120 (2), 7535776 (1) (see all 21)
    autoimmunity 36.4 6 17608818 (1), 11826758 (1), 18303998 (1), 18416318 (1) (see all 6)
    leopard syndrome 36.1 1 16208280 (1)
    favism 34.7 2 8522318 (1), 9116311 (1)
    diabetes autoimmune 32.7 2 18056891 (1)
    immune disorder 32.6 2 18490013 (1), 19246900 (1)

    Genetic Association Database (GAD): ACP1
    Human Genome Epidemiology (HuGE) Navigator: ACP1 (44 documents)

    Export disorders for ACP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACP1 gene, integrated from 9 sources (see all 1493):
    (articles sorted by number of sources associating them with ACP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. (PubMed id 12640337)1, 4, 9 Meloni G....Bottini E. (2003)
    2. Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms. (PubMed id 15281007)1, 4, 9 Bottini N....Bottini E. (2004)
    3. Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women. (PubMed id 12409270)1, 4, 9 Bottini N....Comings D.E. (2002)
    4. Genetic polymorphism and TH1/TH2 orientation. (PubMed id 16224193)1, 4, 9 Bottini N....Bottini E. (2005)
    5. [Genetic predisposition to development of toxic liver cirrhosis caused by alcohol] (PubMed id 11436564)1, 4, 9 Spitsyn V.A....Afanas'eva I.S. (2001)
    6. Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex. (PubMed id 15586390)1, 4, 9 Bottini N....Bottini E. (2005)
    7. Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. (PubMed id 12167657)1, 2, 9 Kikawa K.D....Kinch M.S. (2002)
    8. [Genetic polymorphism of erythrocytic enzymes in Yakut populations] (PubMed id 11963573)1, 4, 9 Tarskaia L.A....Spitsin V.A. (2002)
    9. The genetics of signal transduction and the effect of smoking on intrauterine growth. (PubMed id 11369750)1, 4, 9 Bottini E....Lucarini N. (2001)
    10. Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. (PubMed id 9705307)1, 2, 9 Zhang M.... van Etten R.L. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 52 HGNC: 122 AceView: ACP1 Ensembl:ENSG00000143727 euGenes: HUgn52
    ECgene: ACP1 Kegg: 52 H-InvDB: ACP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACP1 gene:
    Search GeneIP for patents involving ACP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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