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Aliases for ACP1 Gene

Aliases for ACP1 Gene

  • Acid Phosphatase 1, Soluble 2 3 5
  • Low Molecular Weight Cytosolic Acid Phosphatase 3 4
  • Acid Phosphatase Of Erythrocyte 2 3
  • Red Cell Acid Phosphatase 1 3 4
  • Adipocyte Acid Phosphatase 3 4
  • LMW-PTPase 3 4
  • LMW-PTP 3 4
  • Low Molecular Weight Phosphotyrosine Protein Phosphatase 2
  • Cytoplasmic Phosphotyrosyl Protein Phosphatase 3
  • Testicular Secretory Protein Li 37 3
  • Protein Tyrosine Phosphatase 3
  • Red Cell Acid Phosphatase 2
  • EC 3.1.3.48 4
  • EC 3.1.3.2 4
  • HAAP 3

External Ids for ACP1 Gene

Previous GeneCards Identifiers for ACP1 Gene

  • GC02P000258

Summaries for ACP1 Gene

Entrez Gene Summary for ACP1 Gene

  • The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for ACP1 Gene

ACP1 (Acid Phosphatase 1, Soluble) is a Protein Coding gene. Diseases associated with ACP1 include favism and stress polycythemia. Among its related pathways are PDGFR-beta signaling pathway and EPHA2 forward signaling. GO annotations related to this gene include phosphatase activity and acid phosphatase activity.

UniProtKB/Swiss-Prot for ACP1 Gene

  • Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.

Gene Wiki entry for ACP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACP1 Gene

Genomics for ACP1 Gene

Regulatory Elements for ACP1 Gene

Promoters for ACP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACP1 Gene

Chromosome:
2
Start:
264,140 bp from pter
End:
278,283 bp from pter
Size:
14,144 bases
Orientation:
Plus strand

Genomic View for ACP1 Gene

Genes around ACP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACP1 Gene

Proteins for ACP1 Gene

  • Protein details for ACP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24666-PPAC_HUMAN
    Recommended name:
    Low molecular weight phosphotyrosine protein phosphatase
    Protein Accession:
    P24666
    Secondary Accessions:
    • A8K1L9
    • B5MCC7
    • P24667
    • Q16035
    • Q16036
    • Q16725
    • Q3KQX8
    • Q53RU0

    Protein attributes for ACP1 Gene

    Size:
    158 amino acids
    Molecular mass:
    18042 Da
    Quaternary structure:
    • Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoforms 2 or 3. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1.

    Three dimensional structures from OCA and Proteopedia for ACP1 Gene

    Alternative splice isoforms for ACP1 Gene

neXtProt entry for ACP1 Gene

Proteomics data for ACP1 Gene at MOPED

Post-translational modifications for ACP1 Gene

  • Ubiquitination at Lys 113
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ACP1 Gene

Domains & Families for ACP1 Gene

Suggested Antigen Peptide Sequences for ACP1 Gene

Graphical View of Domain Structure for InterPro Entry

P24666

UniProtKB/Swiss-Prot:

PPAC_HUMAN :
  • Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Family:
  • Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
genes like me logo Genes that share domains with ACP1: view

Function for ACP1 Gene

Molecular function for ACP1 Gene

GENATLAS Biochemistry:
phosphatase acid,red cell
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sulfhydryl reagents.
UniProtKB/Swiss-Prot Function:
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.

Enzyme Numbers (IUBMB) for ACP1 Gene

Gene Ontology (GO) - Molecular Function for ACP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA --
genes like me logo Genes that share ontologies with ACP1: view
genes like me logo Genes that share phenotypes with ACP1: view

Animal Models for ACP1 Gene

MGI Knock Outs for ACP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACP1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACP1 Gene

Localization for ACP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACP1 Gene COMPARTMENTS Subcellular localization image for ACP1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ACP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10940933
GO:0009898 cytoplasmic side of plasma membrane IDA 10940933
genes like me logo Genes that share ontologies with ACP1: view

Pathways & Interactions for ACP1 Gene

genes like me logo Genes that share pathways with ACP1: view

Pathways by source for ACP1 Gene

2 BioSystems pathways for ACP1 Gene
1 KEGG pathway for ACP1 Gene

Gene Ontology (GO) - Biological Process for ACP1 Gene

None

No data available for SIGNOR curated interactions for ACP1 Gene

Drugs & Compounds for ACP1 Gene

(63) Drugs for ACP1 Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenine Approved Nutra Target 0
Riboflavin Approved Nutra 150
4-Nitrophenyl phosphate Experimental Pharma Target 0
4-Nitrophenol Experimental Pharma 0
Flavin Mononucleotide Experimental Pharma 6

(62) Additional Compounds for ACP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Tartaric acid
  • (+)-(2R,3R)-Tartaric acid
  • (+)-tartarate
  • (+)-tartaric acid
  • (1R,2R)-1,2-Dihydroxyethane-1,2-dicarboxylic acid
  • (2R,3R)-2,3-dihydroxybutanedioate
87-69-4
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ACP1: view

Transcripts for ACP1 Gene

Unigene Clusters for ACP1 Gene

Acid phosphatase 1, soluble:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -

Relevant External Links for ACP1 Gene

GeneLoc Exon Structure for
ACP1
ECgene alternative splicing isoforms for
ACP1

Expression for ACP1 Gene

mRNA expression in normal human tissues for ACP1 Gene

Protein differential expression in normal tissues from HIPED for ACP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ACP1 Gene



SOURCE GeneReport for Unigene cluster for ACP1 Gene Hs.558296

mRNA Expression by UniProt/SwissProt for ACP1 Gene

P24666-PPAC_HUMAN
Tissue specificity: T-lymphocytes express only isoform 2.
genes like me logo Genes that share expression patterns with ACP1: view

Protein tissue co-expression partners for ACP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ACP1 Gene

Orthologs for ACP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACP1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Acp1 35
  • 84.81 (n)
  • 86.08 (a)
Acp1 16
Acp1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACP1 35
  • 100 (n)
  • 100 (a)
ACP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565965 35
  • 82.91 (n)
  • 80.38 (a)
cow
(Bos Taurus)
Mammalia ACP1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACP1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ACP1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACP1 35
  • 78.48 (n)
  • 82.28 (a)
ACP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACP1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5878 35
zebrafish
(Danio rerio)
Actinopterygii acp1 35
  • 69.44 (n)
  • 75.64 (a)
acp1 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10863 35
fruit fly
(Drosophila melanogaster)
Insecta primo-1 37
  • 46 (a)
primo-1 35
  • 52.48 (n)
  • 47.3 (a)
CG14297 36
  • 19 (a)
OneToMany
CG31469 36
  • 30 (a)
OneToMany
primo-1 36
  • 45 (a)
OneToMany
primo-2 36
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004079 35
  • 55.63 (n)
  • 52.98 (a)
worm
(Caenorhabditis elegans)
Secernentea Y94H6A.7 35
  • 50.43 (n)
  • 47.44 (a)
Y94H6A.7 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LTP1 36
  • 32 (a)
OneToOne
LTP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for ACP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACP1 Gene

ENSEMBL:
Gene Tree for ACP1 (if available)
TreeFam:
Gene Tree for ACP1 (if available)

Paralogs for ACP1 Gene

genes like me logo Genes that share paralogs with ACP1: view

No data available for Paralogs for ACP1 Gene

Variants for ACP1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ACP1 Gene

P24666-PPAC_HUMAN
ACP1 is genetically polymorphic. Three common alleles are known in Caucasians: ACP1*A, ACP1*B and ACP1*C. They give rise to six different phenotypes. Each allele appears to encode two electrophoretically different isozymes, F and S, which are produced in allele-specific ratios (PubMed:1939112). The sequence shown is that of allele ACP1*B and allele ACP1*C.

Sequence variations from dbSNP and Humsavar for ACP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_006171 -
VAR_050526 -
rs35569198 - 277,237(-) AGTCA(A/G)AGTCA nc-transcript-variant, reference, missense
rs6855 -- 277,995(+) GAAAG(A/G)AGGAC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs12503 -- 277,951(+) GCTCC(A/C)ATCTG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACP1 Gene

Variant ID Type Subtype PubMed ID
nsv873529 CNV Gain 21882294
nsv833159 CNV Loss 17160897
essv2780 CNV CNV 17122850
dgv1137e1 CNV Complex 17122850
nsv873530 CNV Gain 21882294
nsv873531 CNV Gain 21882294
essv3569 CNV CNV 17122850
nsv833170 CNV Loss 17160897

Variation tolerance for ACP1 Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACP1 Gene

HapMap Linkage Disequilibrium report
ACP1

Disorders for ACP1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ACP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
favism
  • glucose-6-phosphate dehydrogenase deficiency
stress polycythemia
  • gaisbock's syndrome
obesity
  • obesity, association with
noonan syndrome 1
  • noonan syndrome
myopathy, centronuclear
  • centronuclear myopathy, autosomal, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search ACP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACP1

Genetic Association Database (GAD)
ACP1
Human Genome Epidemiology (HuGE) Navigator
ACP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACP1
genes like me logo Genes that share disorders with ACP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACP1 Gene

Publications for ACP1 Gene

  1. Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1. (PMID: 8586411) Bryson G.L.M. … van Etten R.L. (Genomics 1995) 2 3 4 67
  2. ACP1 genotype, glutathione reductase activity, and riboflavin uptake affect cardiovascular risk in the obese. (PMID: 19570551) Apelt N. … Bicho M.P. (Metab. Clin. Exp. 2009) 3 23
  3. Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms. (PMID: 19789510) Saccucci P. … Gloria-Bottini F. (Med. Sci. Monit. 2009) 3 23
  4. [Genetic polymorphisms of low molecular weight protein tyrosine phosphatase (LMW-PTP): relationship with erythrocyte enzymatic phenotype in patients with Systemic Lupus Erythematosus]. (PMID: 18604186) Esteves Martins M.d.e. .F. … Pires Bicho M.D. (Acta Reumatol Port 2008) 3 23
  5. Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3). (PMID: 17171650) Yoon D.Y. … Singer H.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23

Products for ACP1 Gene

Sources for ACP1 Gene

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