V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ACP1 Gene

protein-coding GIFtS: 69

GC02P000254

acid phosphatase 1, soluble
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.3.48,EC 3.1.3.2 ^³
HAAP ^²
LMW-PTP ^³
LMW-PTPase ^³
MGC111030 ^²
MGC3499 ^²

Descriptions
Adipocyte acid phosphatase ^², ³
Low molecular weight cytosolic acid phosphatase ^³
Red cell acid phosphatase 1 ^², ³
acid phosphatase 1, soluble ^²
acid phosphatase of erythrocyte ^²
cytoplasmic phosphotyrosyl protein phosphatase ^²
low molecular weight phosphotyrosine protein phosphatase ^²
protein tyrosine phosphatase ^²

External Ids
HGNC: 122¹
Entrez Gene: 52²
UniProtKB: P24666³
Ensembl: ENSG00000143727⁷

Search outside databases for aliases for ACP1 gene

Previous GC identifer: GC02P000258

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACP1:

The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It

functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein

tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes

orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic,

and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each

allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are

produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding

distinct isoforms have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666

Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and

synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity

Gene Wiki entry for ACP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACP1 gene

Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25

ACP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P000254: (about GC identifiers)

Start:	254,872 bp from pter
End:	268,283 bp from pter
Size:	13,412 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022327.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666 (See protein sequence)

Recommended Name: Low molecular weight phosphotyrosine protein phosphatase

Size: 158 amino acids; 18042 Da

Subunit: Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for

isoforms 2 or 3

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

1XWW (3D)

5PNT (3D)

Secondary accessions: P24667 Q16035 Q16036 Q16725 Q3KQX8 Q53RU0

Alternative splicing: 3 isoforms: P24666-1 P24666-2, P24667-1 P24666-3 (The ratio of isoform 1 to isoform 2 is 2:1 in allele A, 4:1 in allele B and 1:4 in allele C)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001035739.1 NP_004291.1 NP_009030.1

ENSEMBL proteins:

ENSP00000272066 ENSP00000384184 ENSP00000385404 ENSP00000384307 ENSP00000272065 ENSP00000272067

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ACP1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Acid Phosphatase, Acid phosphatase)
	Human Recombinant Proteins from Abnova (ACP1)

OriGene Purified Recombinant Human Proteins (see all 2): ACP1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	TAS	1587862
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for ACP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACP1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Acid Phosphatase, Acid phosphatase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACP1)
	Novus Biologicals Antibodies for ACP1

Assays for ACP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P24666

ProtoNet protein and cluster: P24666

2 Blocks protein families:

IPB000106 LMW phosphotyrosine protein phosphatase signature

IPB002115 Mammalian LMW phosphotyrosine protein phosphatase signature

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_004300

Applied Biosystems Silencer® siRNAs for ACP1

Sigma-Aldrich siRNA and siRNA Panels for ACP1

Sigma-Aldrich shRNA Panels and shRNA for ACP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040649
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040649
untagged cDNA clones in CMV expression vector (see all 7): BC020699

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007099

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666

Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and

synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate

Enzyme regulation: Inhibited by sulfhydryl reagents

Enzyme Number (IUBMB): EC 3.1.3.48,EC

Genatlas biochemistry entry for ACP1:

phosphatase acid,red cell

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003993	acid phosphatase activity	TAS	1587862
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0042802	identical protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for ACP1 (Your Favorite Gene powered by Ingenuity)

PDGF Signaling
Ephrin Receptor Signaling
Riboflavin Metabolism

GeneDecks ACP1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ACP1

5/37 Interacting proteins for ACP1 (ENSP00000272067³ P24666¹) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACP1	P24666¹	EBI-717701, EBI-717701
ACP2	ENSP00000256997³	STRING (score=.98)
EPHA2	ENSP00000351209³	STRING (score=.96)
ACPP	ENSP00000323036³	STRING (score=.951)
ACP6	ENSP00000358241³	STRING (score=.945)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006470	protein amino acid dephosphorylation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACP1
10/36 Novoseek chemical compound relationships for ACP1 gene (see all 36 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	94.57	3400	16039061 (12), 15477998 (6), 10980198 (5), 8258363 (5) (see all 99)
phosphotyrosine	92.06	208	7679612 (5), 2134890 (3), 8620937 (3), 7686722 (3) (see all 99)
sodium orthovanadate	88.57	74	10230815 (2), 11507066 (2), 8186375 (1), 8014198 (1) (see all 63)
vanadate	88.28	138	11980490 (4), 2154464 (3), 9878539 (2), 10439081 (2) (see all 99)
raytide	80.64	5	1318316 (1), 7684610 (1), 8256510 (1)
p-nitrophenyl phosphate	77.13	7	8127855 (2), 2134890 (1), 7528537 (1), 7589546 (1) (see all 6)
dephostatin	73.95	8	8557604 (4), 8226312 (1)
bpv(phen)	71.60	3	16039061 (1), 11792460 (1)
benzylphosphonic acid	70.50	2	9458714 (1), 9106619 (1)
cl 100	68.49	8	7780739 (2), 8106404 (2), 8390041 (1), 7806236 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_004300

Sigma-Aldrich siRNA and siRNA Panels for ACP1

Sigma-Aldrich shRNA Panels and shRNA for ACP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001040649 NM_004300 NM_007099

REFSEQ mRNAs for ACP1 gene (3 alternative transcripts):

NM_001040649.2 NM_004300.3 NM_007099.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001040649 NM_004300 NM_007099

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040649
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040649
                                 untagged cDNA clones in CMV expression vector (see all 7): BC020699

Additional cDNA sequence:

AB209838.1 AK289934.1 AK291861.1 BC007422.2 BC106011.1 BT007136.1 CR591454.1 CR597555.1

CR599434.1 CR607431.1 CR609595.1 CR609802.1 CR613475.1 CR624312.1 M83653.1 M83654.1

M87545.1 S62884.1 Y16846.1

20 DOTS entries:

DT.100842980 DT.99931855 DT.100030203 DT.454219 DT.100842972 DT.100842978 DT.119141 DT.121013711

DT.100742580 DT.100842976 DT.95256266 DT.100842982 DT.119140 DT.95256302 DT.121013776 DT.121013819

DT.91759792 DT.95256278 DT.121417499 DT.99984839

24/473 AceView cDNA sequences (see all 473 ):

CD251736 CR599434 NM_004300 CR609595 BM477153 CR597555 BM970524 AW769370

BM770461 CD675878 AA568474 BM460072 CD673215 BU539875 BE905801 BM793724

NM_007099 BF726270 BM825165 BE618323 AI056981 BG056276 AI167367 AL573837

highest scoring ESTs for ACP1:

AA037447 AA037448 AA056583 AA115242 AA130244 AA130248 AA205145 AA467733 AA467801 AA479138

Unigene Cluster for ACP1:

Acid phosphatase 1, soluble

Hs.558296 [show with all ESTs]

Unigene Representative Sequence: NM_004300

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACP1 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	·	9g
SP1:											-						-						-		-		-
SP2:											-		-				-				-		-				-
SP3:											-		-				-		-		-		-				-
SP4:											-		-				-						-		-		-
SP5:													-				-						-		-		-

About this scheme

ECgene alternative splicing isoforms for ACP1

6 Ensembl transcripts including schematic representations:

ENST00000272066 ENST00000405364 ENST00000407983 ENST00000405233 ENST00000272065 ENST00000272067

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACP1

¹ / ² / ³

8 probe-sets matching ACP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36611_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U25849	0.20	1.00	0.72	1
201630_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004300	0.60	1.00	0.82	1
201629_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	BE872974	0.80	1.00	0.91	1
215227_x_at²^{, 3}	U133-A	2	0.91	0.95	--	--	BG035989	0.80	1.00	0.91	1
1554808_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201630_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201629_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--
215227_x_at²	U133Plus2	2	0.91	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATATTTCAA

SOURCE GeneReport for Unigene cluster: Hs.558296
Expression variation in blood from EXPOLDB for ACP1
UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
Tissue specificity: T-lymphocytes express only isoform 2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACP1 gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ACP1¹	--	acid phosphatase 1, soluble	100(n) 100(a)	458990 XM_001149653.1 XP_001149653.1
cow (Bos taurus)	ACP1¹	--	acid phosphatase 1, soluble	91.03(n) 94.87(a)	280977 NM_173978.2 NP_776403.1
rat (Rattus norvegicus)	Acp1¹	--	acid phosphatase 1, soluble	79.54(n) 81.01(a)	24161 NM_021262.2 NP_067085.1
mouse (Mus musculus)	Acp1^{1, 5}	12⁵	acid phosphatase 1, soluble^{1, 5}	80.17(n)¹ 81.01(a)¹	11431¹ NM_021330.3¹ NP_067305.2¹ AA000199⁵ AI427468⁵ (see all 33)
chicken (Gallus gallus)	ACP1¹	--	acid phosphatase 1, soluble	72.36(n) 74.05(a)	421909 NM_001039291.1 NP_001034380.1

About this table Species with no ortholog for ACP1

ENSEMBL Gene Tree for ACP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

3 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666

Polymorphism: ACP1 is genetically polymorphic. Three common alleles are known in Caucasians:

ACP1*A, ACP1*B and ACP1*C. They give rise to six different phenotypes. Each allele appears to

encode two electrophoretically different isozymes, F and S, which are produced in allele-specific

ratios. The sequence shown is that of allele ACP1*B and allele ACP1*C

10/95 NCBI SNPs in ACP1 are shown (see all 95 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 49)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6855^1,2	A,C,F,H	267995(+)	`GAAAGA/GAGGAC`	2	--	ut3¹ trp³		13	MN EU EA WA	1442
	rs12714402^1,2	A,C,F,H	262926(+)	`TCTTCG/ATTGGT`	3	--	ng3¹ int¹		8	EU EA WA NA	632
--	rs12714401^1,2	A,C,F,H	262840(+)	`ATTATA/GAATTA`	3	--	int¹ ng3¹		4	EU EA WA	412
	rs11127466^1,2	A,C,F,H	268752(+)	`ACCCAG/CTGAGT`	2	--	ng3¹		13	NA EU EA WA	1152
	rs7605924^1,2	F,H	262626(+)	`TCATCC/GTGCTG`	3	--	int¹ ng3¹		4	EU EA WA	416
	rs11553746^1,2	C,F	262203(+)	`ATTGAC/TAGCGG`	3	D/D T/I	syn¹ mis¹ int¹		5	NA EU EA WA	496
	rs35569198^1,2	C,F	267237(-)	`AGTCAG/AAGTCA`	2	F/S	mis¹		5	NA EU EA WA	494
	rs12503^1,2	H	267951(+)	`GCTCCC/AATCTG`	2	--	ut3¹ ese³		5	MN EU EA WA	598
	rs3020774^1,2	H	262471(+)	`GAAAGA/GCTTGC`	3	--	int¹ ut3¹		4	EU EA WA	420
	rs11553742^1,2	C,F	262051(+)	`GACAGC/TGCGGC`	3	S/S	syn¹ int¹ ese³		3	NA	138

About this table

HapMap Linkage Disequilibrium images for ACP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 171500

10/90 Novoseek disease relationships for ACP1 gene (see all 90 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
noonan syndrome	69.18	10	15240615 (2), 12161469 (2), 16208280 (1), 19407499 (1) (see all 8)
bubonic plague	61.79	7	1723471 (1), 14609321 (1), 8052312 (1), 7803389 (1) (see all 5)
myotubular myopathy	51.08	2	10900271 (1), 11056007 (1)
lafora disease	46.82	6	9771710 (1), 16134145 (1), 14643920 (1), 17010495 (1) (see all 5)
insulin resistance	39.92	32	18925540 (4), 15271787 (2), 7769120 (2), 7535776 (1) (see all 21)
leopard syndrome	38.27	1	16208280 (1)
favism	36.02	2	8522318 (1), 9116311 (1)
autoimmunity	34.39	6	17608818 (1), 11826758 (1), 18303998 (1), 18416318 (1) (see all 6)
immune disorder	30.31	1	18490013 (1)
autoimmune diseases	27.54	10	17868256 (1), 10885457 (1), 18056891 (1), 16163373 (1) (see all 10)

About this table

Genetic Association Database: ACP1
Human Genome Epidemiology Navigator: ACP1 (29 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1298 PubMed articles for ACP1 gene (see all 1298 ):

Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. (PubMed id 12640337)^{1, 3, 6} Meloni G....Bottini E. (2003)
Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms. (PubMed id 15281007)^{1, 3, 6} Bottini N....Bottini E. (2004)
Genetic polymorphism and TH1/TH2 orientation. (PubMed id 16224193)^{1, 3, 6} Bottini N....Bottini E. (2005)
[Genetic predisposition to development of toxic liver cirrhosis caused by alcohol] (PubMed id 11436564)^{1, 3, 6} Spitsyn V.A....Afanas'eva I.S. (2001)
Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex. (PubMed id 15586390)^{1, 3, 6} Bottini N....Bottini E. (2005)
[Genetic polymorphism of erythrocytic enzymes in Yakut populations] (PubMed id 11963573)^{1, 3, 6} Tarskaia L.A....Spitsin V.A. (2002)
Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women. (PubMed id 12409270)^{1, 3, 6} Bottini N....Comings D.E. (2002)
The genetics of signal transduction and the effect of smoking on intrauterine growth. (PubMed id 11369750)^{1, 3, 6} Bottini E....Lucarini N. (2001)
Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. (PubMed id 9705307)^{1, 3, 4} Zhang M.... van Etten R.L. (1998)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 52	HGNC: 122	AceView: ACP1	Ensembl:ENSG00000143727	euGenes: HUgn52
ECgene: ACP1	H-InvDB: ACP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ACP1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ACP1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACP1		Antibodies for ACP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACP1)
	Antibodies (ACP1)
	Chimera RNAi (ACP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Acid Phosphatase, Acid phosphatase)
	Antibodies (Acid Phosphatase, Acid phosphatase)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ACP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACP1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ACP1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ACP1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ACP1

Summaries
for ACP1

Genomic Location
for ACP1

Proteins
for ACP1

Protein Domains/
Families
for ACP1

Gene Function
for ACP1

Pathways & Interactions
for ACP1

Drugs & Compounds
for ACP1

Transcripts
for ACP1

Expression
for ACP1

Orthologs
for ACP1

Paralogs
for ACP1

SNPs/Variants
for ACP1

Disorders & Mutations
for ACP1

Medical News
for ACP1

Publications
for ACP1

Search for ACP1

Genome Databases showing ACP1

Other Databases showing ACP1

Specialized Databases showing ACP1

Licensable Technologies
for ACP1

Services
for ACP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACP1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ACP1

Summariesfor ACP1

Genomic Locationfor ACP1

Proteinsfor ACP1

Protein Domains/Familiesfor ACP1

Gene Functionfor ACP1

Pathways & Interactionsfor ACP1

Drugs & Compoundsfor ACP1

Transcriptsfor ACP1

Expression for ACP1

Orthologsfor ACP1

Paralogsfor ACP1

SNPs/Variantsfor ACP1

Disorders & Mutationsfor ACP1

Medical Newsfor ACP1

Publicationsfor ACP1

Search for ACP1

Genome Databases showing ACP1

Other Databases showing ACP1

Specialized Databases showing ACP1

Licensable Technologiesfor ACP1

Servicesfor ACP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACP1

Summaries
for ACP1

Genomic Location
for ACP1

Proteins
for ACP1

Protein Domains/
Families
for ACP1

Gene Function
for ACP1

Pathways & Interactions
for ACP1

Drugs & Compounds
for ACP1

Transcripts
for ACP1

Expression
for ACP1

Orthologs
for ACP1

Paralogs
for ACP1

SNPs/Variants
for ACP1

Disorders & Mutations
for ACP1

Medical News
for ACP1

Publications
for ACP1

Licensable Technologies
for ACP1

Services
for ACP1