ACOXL Gene
protein-coding GIFtS : 43
GCID: GC02 P112074
acyl-CoA oxidase-like (Previous name: acyl-Coenzyme A oxidase-like )
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Aliasesfor ACOXL gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Acyl-CoA Oxidase-Like 1 2 Acyl-CoA Oxidase-Like Protein2 3 FLJ110421 Acyl-Coenzyme A Oxidase-Like1 Acyl-Coenzyme A Oxidase-Like Protein2 EC 1.3.3.-3
Export aliases for ACOXL gene to outside databases Previous GC identifers: GC02P111586 GC02P111206 GC02P104369 GC02P111587 GC02P111729
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Summariesfor ACOXL gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor ACOXL gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022135.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ACOXL gene promoter: E2F-1 E2F Pax-5 FOXD3 FOXO3a FOXO3 FOXO3b Other transcription factors Search SABiosciences Chromatin IP Primers for ACOXL Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ACOXL
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13 ACOXL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P112074: view genomic region
(about GC identifiers )
Start:
111,490,150 bp from pter
End:
111,875,799 bp from pter
Size:
385,650 bases
Orientation:
plus strand
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Proteinsfor ACOXL gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ACOXL_HUMAN, Q9NUZ1 (See
protein sequence )Recommended Name: Acyl-coenzyme A oxidase-like protein Size : 547 amino acids; 61795 Da
Cofactor : FAD (By similarity)
Sequence caution : Sequence=AAH22268.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=BAA91970.1;Type=Erroneous initiation;
Secondary accessions : A2RRB7 B7WPB3 B7WPP7 Q53R27 Q53R31 Q53SC6 Q8TCE7Alternative splicing : 3 isoforms : Q9NUZ1-1 Q9NUZ1-2 Q9NUZ1-3 Explore the universe of human proteins at neXtProt for ACOXL: NX_Q9NUZ1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NUZ1 ACOXL Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001136279.1 ENSEMBL proteins: ENSP00000374461 ENSP00000407761 ENSP00000343717 ENSP00000394701 ENSP00000387832 ENSP00000406774 ENSP00000409500 ENSP00000393823 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
ACOXL for ontologies About GeneDecksing ACOXL Antibody Products: Assay Products for ACOXL:
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Protein
Domains / Familiesfor ACOXL gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ACOXL for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q9NUZ1 ProtoNet protein and cluster: Q9NUZ1
UniProtKB/Swiss-Prot: ACOXL_HUMAN, Q9NUZ1 Similarity : Belongs to the acyl-CoA oxidase family
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Functionfor ACOXL gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Enzyme Number (IUBMB): EC 1.3.3.- 1 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACOXL (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACOXL (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ACOXL (NM_001142807 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACOXL Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ACOXL
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOXL
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND -- GO:0003995 acyl-CoA dehydrogenase activity
IEA -- GO:0003997 acyl-CoA oxidase activity
IEA -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
-- -- GO:0050660 flavin adenine dinucleotide binding
IEA --
ACOXL for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for ACOXL :
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Pathways & Interactionsfor ACOXL gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACOXL Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006631 fatty acid metabolic process
-- -- GO:0006635 fatty acid beta-oxidation
IEA -- GO:0008150 biological_process
ND --
ACOXL for ontologies About GeneDecksing
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Drugs & Compoundsfor ACOXL gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ACOXL 10/33 HMDB Compounds for ACOXL (see all 33 ) About this table Search CenterWatch for drugs/clinical trials and news about ACOXL
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Transcriptsfor ACOXL gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ACOXL gene (4 alternative transcripts): NM_001105516.2 NM_001142808.1 NM_018308.1 NM_001142807.1 Unigene Cluster for ACOXL:
Acyl-CoA oxidase-like Hs.253320 [show with all ESTs ] Unigene Representative Sequence: NM_001142807 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000389811 (uc021vmm.1 uc021vmn.1 ) ENST00000439055 (uc010yxk.1 )ENST00000340561 ENST00000448863 ENST00000461340 ENST00000417074 ENST00000433706 ENST00000443586 ENST00000441974 ENST00000496981 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACOXL (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACOXL (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ACOXL (NM_001142807 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACOXL Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ACOXL
Additional cDNA sequence: AK001904.1 AK300513.1 BC022268.1 BC131514.1
3 DOTS entries : DT.40128781 DT.100022202
DT.91669188 24/26 AceView cDNA sequences (see all 26 ):
CK904788 BC022268 BM069702 BX282060 AI660659 AA015638 AA948246 BM069858 AA620835 AW630376 AU136508 CK904787 BF064226 AA927358 AK001904 BF064280 BM069609 BG619029 AI659238 NM_018308 BX118900 BX099110 AW627350 BI819505 GeneLoc Exon Structure
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Expression for ACOXL gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ACOXL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCAGCACGA
About this image ACOXL expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ACOXL Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ACOXL SOURCE GeneReport for Unigene cluster: Hs.253320 SABiosciences Custom PCR Arrays for ACOXL Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ACOXLBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ACOXL QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ACOXL QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ACOXL In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOXL
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Orthologsfor ACOXL gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ACOXL gene from 3/14 species (see all 14 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
zebrafish (Danio rerio)
Actinopterygii
acoxl1
acyl-Coenzyme A oxidase-like
64.77(n) 65.78(a)
 
569104 XM_692467.3 XP_697559.3
thale cress (Arabidopsis thaliana)
eudicotyledons
ACX21
acyl-coenzyme A oxidase 2
45.21(n) 38.67(a)
 
836635 NM_125910.5 NP_201316.1
rice (Oryza sativa)
Liliopsida
--
acyl-coenzyme A oxidase, putative, expressed
24(a)
1 ↔ 1
6(14503078-14511951)
ENSEMBL Gene Tree for ACOXL (if available)TreeFam Gene Tree for ACOXL (if available)
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Paralogsfor ACOXL gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ACOXL gene ACOX2 2 ACOX1 2 ACOX3 2 2 SIMAP similar genes for ACOXL using alignment to 6 protein entries: ACOXL_HUMAN (see all proteins ):ACOX3 ACOX1
ACOXL for paralogs About GeneDecksing
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Genomic Variantsfor ACOXL gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ACOXL (111490150 - 111740150 bp, first 250kb of ACOXL)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for ACOXL 2 CNVs : 58905 58904 2 Indels : 61806 40353
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ACOXL
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Disorders
/ Diseasesfor ACOXL gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ACOXL for disorders About GeneDecksing 4 diseases for ACOXL : About MalaCards acyl-coa dehydrogenase chronic lymphocytic leukemia lymphocytic leukemia leukemia Human Genome Epidemiology (HuGE) Navigator: ACOXL (3 documents) Export disorders for ACOXL gene to outside databases
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Publicationsfor ACOXL gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ACOXL gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with ACOXL) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. (PubMed id 22700719) 1 Slager S.L....Houlston R.S. (2012) A genome-wide association study in Han Chinese identif ies multiple susceptibility loci for IgA nephropathy. (PubMed id 22197929) 1 Yu X.Q....Liu J.J. (2012) A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177) 1 Tao S....Sun J. (2012) The genetic architecture of economic and political pre ferences. (PubMed id 22566634) 1 Benjamin D.J....Visscher P.M. (2012) Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478) 1 Okada Y....Kamatani N. (2011) Genetic susceptibility for chronic lymphocytic leukem ia among Chinese in Hong Kong. (PubMed id 20731705) 1 Lan Q....Rothman N. (2010) Genetic susceptibility variants for chronic lymphocyt ic leukemia. (PubMed id 20332261) 1 Slager S.L....Cerhan J.R. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279) 1 Hosgood H.D....Lan Q. (2009)
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External Searches for ACOXL gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ACOXL gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ACOXL gene
(According to HUGE )
About This Section --
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Specialized Databases showing ACOXL gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ACOXL Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ACOXL gene: Search GeneIP for patents involving ACOXL GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ACOXL gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ACOXL OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ACOXL OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ACOXL OriGene Protein Over-expression Lysate for ACOXL Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ACOXL Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACOXL OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACOXL Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACOXL QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ACOXL QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ACOXL QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ACOXL QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ACOXL QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ACOXL
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ACOXL Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOXL
ThermoFisher Antibody for ACOXL
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Aliases for ACOXL
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Disorders / Diseases for ACOXL
Domains / Families for ACOXL
Drugs / Compounds for ACOXL
Expression for ACOXL
Function for ACOXL
Genomic Views for ACOXL
Intellectual Property for ACOXL
Orthologs for ACOXL
Paralogs for ACOXL
Pathways / Interactions for ACOXL
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Proteins for ACOXL
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Summaries for ACOXL
Transcripts for ACOXL
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