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Aliases for ACOXL Gene

Aliases for ACOXL Gene

  • Acyl-CoA Oxidase-Like 2 3 5
  • Acyl-CoA Oxidase-Like Protein 4
  • Acyl-Coenzyme A Oxidase-Like 2
  • EC 1.3.3.- 4

External Ids for ACOXL Gene

Previous GeneCards Identifiers for ACOXL Gene

  • GC02P111586
  • GC02P111206
  • GC02P104369
  • GC02P111587
  • GC02P111729
  • GC02P112074
  • GC02P112268
  • GC02P112536

Summaries for ACOXL Gene

GeneCards Summary for ACOXL Gene

ACOXL (Acyl-CoA Oxidase-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisomal lipid metabolism. GO annotations related to this gene include flavin adenine dinucleotide binding and acyl-CoA dehydrogenase activity. An important paralog of this gene is ACOX3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOXL Gene

Genomics for ACOXL Gene

Regulatory Elements for ACOXL Gene

Enhancers for ACOXL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACOXL on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOXL Gene

110,732,539 bp from pter
111,120,610 bp from pter
388,072 bases
Plus strand

Genomic View for ACOXL Gene

Genes around ACOXL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOXL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOXL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOXL Gene

Proteins for ACOXL Gene

  • Protein details for ACOXL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A oxidase-like protein
    Protein Accession:
    Secondary Accessions:
    • A2RRB7
    • B7WPB3
    • B7WPP7
    • E9PB20
    • Q53R27
    • Q53R31
    • Q53SC6
    • Q8TCE7

    Protein attributes for ACOXL Gene

    547 amino acids
    Molecular mass:
    61795 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    • Sequence=AAH22268.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAA91970.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ACOXL Gene


neXtProt entry for ACOXL Gene

Proteomics data for ACOXL Gene at MOPED

Post-translational modifications for ACOXL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACOXL Gene

Domains & Families for ACOXL Gene

Suggested Antigen Peptide Sequences for ACOXL Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the acyl-CoA oxidase family.
  • Belongs to the acyl-CoA oxidase family.
genes like me logo Genes that share domains with ACOXL: view

No data available for Gene Families for ACOXL Gene

Function for ACOXL Gene

Enzyme Numbers (IUBMB) for ACOXL Gene

Gene Ontology (GO) - Molecular Function for ACOXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IBA --
GO:0003674 molecular_function ND --
GO:0009055 electron carrier activity IBA --
GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor IBA --
genes like me logo Genes that share ontologies with ACOXL: view
genes like me logo Genes that share phenotypes with ACOXL: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACOXL Gene

Localization for ACOXL Gene

Subcellular locations from

Jensen Localization Image for ACOXL Gene COMPARTMENTS Subcellular localization image for ACOXL gene
Compartment Confidence
peroxisome 5
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACOXL Gene

Pathways & Interactions for ACOXL Gene

genes like me logo Genes that share pathways with ACOXL: view

Pathways by source for ACOXL Gene

Interacting Proteins for ACOXL Gene

Gene Ontology (GO) - Biological Process for ACOXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0055088 lipid homeostasis IBA --
genes like me logo Genes that share ontologies with ACOXL: view

No data available for SIGNOR curated interactions for ACOXL Gene

Drugs & Compounds for ACOXL Gene

(2) Drugs for ACOXL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACOXL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with ACOXL: view

Transcripts for ACOXL Gene

Unigene Clusters for ACOXL Gene

Acyl-CoA oxidase-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOXL Gene

No ASD Table

Relevant External Links for ACOXL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOXL Gene

mRNA expression in normal human tissues for ACOXL Gene

mRNA differential expression in normal tissues according to GTEx for ACOXL Gene

This gene is overexpressed in Lung (x10.2), Bladder (x9.8), Testis (x5.9), and Prostate (x4.4).

Protein differential expression in normal tissues from HIPED for ACOXL Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACOXL Gene

SOURCE GeneReport for Unigene cluster for ACOXL Gene Hs.253320

genes like me logo Genes that share expression patterns with ACOXL: view

Protein tissue co-expression partners for ACOXL Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ACOXL Gene

Orthologs for ACOXL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOXL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACOXL 35
  • 86.15 (n)
  • 84.31 (a)
  • 84 (a)
(Canis familiaris)
Mammalia ACOXL 35
  • 89.71 (n)
  • 89.83 (a)
  • 90 (a)
(Mus musculus)
Mammalia Acoxl 35
  • 80.72 (n)
  • 76.69 (a)
Acoxl 16
Acoxl 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Acoxl 35
  • 80.37 (n)
  • 76.87 (a)
(Monodelphis domestica)
Mammalia ACOXL 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ACOXL 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acoxl 35
  • 70.97 (n)
  • 76.32 (a)
(Danio rerio)
Actinopterygii acoxl 35
  • 64.82 (n)
  • 65.78 (a)
acoxl 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POX1 36
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACX2 35
  • 46.14 (n)
  • 39.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 9 (a)
-- 36
  • 18 (a)
CSA.6640 36
  • 27 (a)
Species with no ortholog for ACOXL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOXL Gene

Gene Tree for ACOXL (if available)
Gene Tree for ACOXL (if available)

Paralogs for ACOXL Gene

Paralogs for ACOXL Gene

(2) SIMAP similar genes for ACOXL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ACOXL: view

Variants for ACOXL Gene

Sequence variations from dbSNP and Humsavar for ACOXL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1554005 - 110,841,381(+) GTTGA(A/C/T)GATAG nc-transcript-variant, reference, missense
rs17041850 - 111,092,938(+) GACTC(C/T)CATGG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs717031 -- 110,872,691(-) AGGGC(A/G)GCCGG intron-variant
rs729386 -- 110,948,161(+) GTCTC(A/G)AAAAA intron-variant
rs731969 -- 111,056,520(-) TGAGC(C/T)ACCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOXL Gene

Variant ID Type Subtype PubMed ID
nsv874838 CNV Loss 21882294
nsv521956 CNV Loss 19592680
nsv874839 CNV Gain 21882294
esv2720513 CNV Deletion 23290073
esv2658917 CNV Deletion 23128226
esv2720514 CNV Deletion 23290073
esv2720515 CNV Deletion 23290073
esv7277 CNV Loss 19470904
nsv834330 CNV Gain 17160897
dgv4272n71 CNV Loss 21882294
esv267520 CNV Insertion 20981092
esv273432 CNV Insertion 20981092
nsv819214 CNV Loss 19587683
nsv819716 CNV Gain 19587683
nsv834331 CNV Loss 17160897
esv2666908 CNV Deletion 23128226
nsv874842 CNV Loss 21882294
nsv829618 CNV Gain 20364138

Variation tolerance for ACOXL Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.27; 92.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACOXL Gene

Disorders for ACOXL Gene

Relevant External Links for ACOXL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACOXL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOXL Gene

Publications for ACOXL Gene

  1. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu X.Q. … Liu J.J. (Nat. Genet. 2012) 3 48 67
  2. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 3
  3. Genome-wide diet-gene interaction analyses for risk of colorectal cancer. (PMID: 24743840) Figueiredo J.C. … . (PLoS Genet. 2014) 3
  4. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. (PMID: 23770605) Berndt S.I. … Slager S.L. (Nat. Genet. 2013) 3
  5. Genetics of rheumatoid arthritis contributes to biology and drug discovery. (PMID: 24390342) Okada Y. … Plenge R.M. (Nature 2013) 3

Products for ACOXL Gene

Sources for ACOXL Gene