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Aliases for ACOXL Gene

Aliases for ACOXL Gene

  • Acyl-CoA Oxidase-Like 2 3 5
  • Acyl-CoA Oxidase-Like Protein 4
  • Acyl-Coenzyme A Oxidase-Like 2
  • EC 1.3.3.- 4

External Ids for ACOXL Gene

Previous GeneCards Identifiers for ACOXL Gene

  • GC02P111586
  • GC02P111206
  • GC02P104369
  • GC02P111587
  • GC02P111729
  • GC02P112074
  • GC02P112268
  • GC02P112536

Summaries for ACOXL Gene

GeneCards Summary for ACOXL Gene

ACOXL (Acyl-CoA Oxidase-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisomal lipid metabolism. GO annotations related to this gene include flavin adenine dinucleotide binding and acyl-CoA dehydrogenase activity. An important paralog of this gene is ACOX1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOXL Gene

Genomics for ACOXL Gene

Regulatory Elements for ACOXL Gene

Enhancers for ACOXL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F110709 0.5 Ensembl 12.1 -23.2 -23239 0.6 L3MBTL2 RNF2 CEBPB MNT ARID1B ATF3 FOXK2 ZNF512 TRIM24 FOS ACOXL LINC00116 GC02P112740 GC02P112833 PIR34530 PIR61329
GH02F110687 1.3 FANTOM5 Ensembl ENCODE 11.6 -44.2 -44248 2.6 CBX3 TEAD4 ZIC2 JUND BCL11A IKZF1 POU5F1 MAFK SETDB1 ACOXL ENSG00000186148 LINC01123 NPHP1 PIR37875 PIR41734
GH02F110673 0.2 ENCODE 11.5 -55.5 -55547 6.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 FOS KLF13 ACOXL LINC00116 LINC01123 ENSG00000186148 BUB1 RPL22P12
GH02F110732 0.7 ENCODE 0.8 +0.1 50 1.1 ZSCAN5A KLF1 SUZ12 KLF17 ZFHX2 GLIS2 POLR2A ZNF366 PATZ1 PRDM10 ENSG00000184115 ENSG00000186148 ACOXL GC02P112960
GH02F110741 0.4 ENCODE 0.4 +9.3 9280 0.2 CTCF GATA3 RNF2 PATZ1 BHLHE40 EGR2 ACOXL GC02P112960
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ACOXL on UCSC Golden Path with GeneCards custom track

Promoters for ACOXL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001826150 61 401 ZSCAN5A KLF1 SUZ12 KLF17 ZFHX2 POLR2A ZNF366 PATZ1 KLF7 ZBTB20

Genomic Location for ACOXL Gene

110,732,539 bp from pter
111,120,610 bp from pter
388,072 bases
Plus strand

Genomic View for ACOXL Gene

Genes around ACOXL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOXL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOXL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOXL Gene

Proteins for ACOXL Gene

  • Protein details for ACOXL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A oxidase-like protein
    Protein Accession:
    Secondary Accessions:
    • A2RRB7
    • B7WPB3
    • B7WPP7
    • E9PB20
    • Q53R27
    • Q53R31
    • Q53SC6
    • Q8TCE7

    Protein attributes for ACOXL Gene

    547 amino acids
    Molecular mass:
    61795 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    • Sequence=AAH22268.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAA91970.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ACOXL Gene


neXtProt entry for ACOXL Gene

Post-translational modifications for ACOXL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACOXL Gene

Domains & Families for ACOXL Gene

Suggested Antigen Peptide Sequences for ACOXL Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the acyl-CoA oxidase family.
  • Belongs to the acyl-CoA oxidase family.
genes like me logo Genes that share domains with ACOXL: view

No data available for Gene Families for ACOXL Gene

Function for ACOXL Gene

Enzyme Numbers (IUBMB) for ACOXL Gene

Gene Ontology (GO) - Molecular Function for ACOXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IBA --
GO:0003674 molecular_function ND --
GO:0003995 acyl-CoA dehydrogenase activity IBA --
GO:0003997 acyl-CoA oxidase activity IEA --
GO:0009055 electron carrier activity IBA --
genes like me logo Genes that share ontologies with ACOXL: view
genes like me logo Genes that share phenotypes with ACOXL: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACOXL Gene

Localization for ACOXL Gene

Subcellular locations from

Jensen Localization Image for ACOXL Gene COMPARTMENTS Subcellular localization image for ACOXL gene
Compartment Confidence
peroxisome 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACOXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IEA,IBA --
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with ACOXL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACOXL Gene

Pathways & Interactions for ACOXL Gene

genes like me logo Genes that share pathways with ACOXL: view

Pathways by source for ACOXL Gene

Interacting Proteins for ACOXL Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)
Selected Interacting proteins: ENSP00000407761 Q9NUZ1-ACOXL_HUMAN for ACOXL Gene via STRING IID

Gene Ontology (GO) - Biological Process for ACOXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006635 fatty acid beta-oxidation IEA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA --
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase TAS --
genes like me logo Genes that share ontologies with ACOXL: view

No data available for SIGNOR curated interactions for ACOXL Gene

Drugs & Compounds for ACOXL Gene

(2) Drugs for ACOXL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACOXL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with ACOXL: view

Transcripts for ACOXL Gene

Unigene Clusters for ACOXL Gene

Acyl-CoA oxidase-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOXL Gene

No ASD Table

Relevant External Links for ACOXL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOXL Gene

mRNA expression in normal human tissues for ACOXL Gene

mRNA differential expression in normal tissues according to GTEx for ACOXL Gene

This gene is overexpressed in Lung (x10.2), Bladder (x9.8), Testis (x5.9), and Prostate (x4.4).

Protein differential expression in normal tissues from HIPED for ACOXL Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACOXL Gene

Protein tissue co-expression partners for ACOXL Gene

NURSA nuclear receptor signaling pathways regulating expression of ACOXL Gene:


SOURCE GeneReport for Unigene cluster for ACOXL Gene:

genes like me logo Genes that share expression patterns with ACOXL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ACOXL Gene

Orthologs for ACOXL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOXL Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ACOXL 34 35
  • 89.71 (n)
(Bos Taurus)
Mammalia ACOXL 34 35
  • 86.15 (n)
(Mus musculus)
Mammalia Acoxl 34 16 35
  • 80.72 (n)
(Rattus norvegicus)
Mammalia Acoxl 34
  • 80.37 (n)
(Monodelphis domestica)
Mammalia ACOXL 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ACOXL 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acoxl 34
  • 70.97 (n)
(Danio rerio)
Actinopterygii acoxl 34 35
  • 64.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POX1 35
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACX2 34
  • 46.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6640 35
  • 27 (a)
-- 35
  • 18 (a)
-- 35
  • 9 (a)
Species where no ortholog for ACOXL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOXL Gene

Gene Tree for ACOXL (if available)
Gene Tree for ACOXL (if available)

Paralogs for ACOXL Gene

Paralogs for ACOXL Gene

(2) SIMAP similar genes for ACOXL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ACOXL: view

Variants for ACOXL Gene

Sequence variations from dbSNP and Humsavar for ACOXL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1002015 -- 110,859,042(+) CAAAT(C/T)GCAAA intron-variant
rs1002016 -- 110,859,335(+) GTTTC(A/G)TGTGC intron-variant
rs10048703 -- 110,832,983(+) AGATC(A/G)TCAAG intron-variant
rs10048706 -- 110,833,459(+) CGGTC(A/G)CCATG intron-variant
rs10048841 -- 111,105,449(+) atctt(C/G)cagtc intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACOXL Gene

Variant ID Type Subtype PubMed ID
dgv1994n106 CNV deletion 24896259
dgv4047n100 CNV loss 25217958
dgv4048n100 CNV loss 25217958
dgv730e214 CNV gain 21293372
esv2658917 CNV deletion 23128226
esv2666908 CNV deletion 23128226
esv2720513 CNV deletion 23290073
esv2720514 CNV deletion 23290073
esv2720515 CNV deletion 23290073
esv2762272 CNV loss 21179565
esv3303240 CNV mobile element insertion 20981092
esv3309159 CNV mobile element insertion 20981092
esv3428994 CNV insertion 20981092
esv3559939 CNV deletion 23714750
esv3584011 CNV loss 25503493
esv3591965 CNV gain 21293372
esv3591969 CNV insertion 21293372
esv3591970 CNV loss 21293372
esv3591972 CNV loss 21293372
esv3591974 CNV loss 21293372
esv3591977 CNV loss 21293372
esv7277 CNV loss 19470904
nsv1148884 CNV deletion 26484159
nsv1149522 OTHER inversion 26484159
nsv521956 CNV loss 19592680
nsv582699 CNV loss 21841781
nsv819214 CNV loss 19587683
nsv819716 CNV gain 19587683
nsv829618 CNV gain 20364138
nsv834330 CNV gain 17160897
nsv834331 CNV loss 17160897
nsv955063 CNV deletion 24416366
nsv963699 CNV duplication 23825009

Variation tolerance for ACOXL Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.27; 92.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOXL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOXL Gene

Disorders for ACOXL Gene

Relevant External Links for ACOXL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACOXL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOXL Gene

Publications for ACOXL Gene

  1. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu X.Q. … Liu J.J. (Nat. Genet. 2012) 3 46 64
  2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 46 64
  3. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y. … Kamatani N. (PLoS Genet. 2011) 3 46 64
  4. Genetic susceptibility variants for chronic lymphocytic leukemia. (PMID: 20332261) Slager S.L. … Cerhan J.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  5. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. (PMID: 20731705) Lan Q. … Rothman N. (Eur. J. Haematol. 2010) 3 46 64

Products for ACOXL Gene

Sources for ACOXL Gene

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