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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACOXL Gene

protein-coding   GIFtS: 43
GCID: GC02P112074

acyl-CoA oxidase-like

(Previous name: acyl-Coenzyme A oxidase-like )
 Explore 4 diseases affiliated with
ACOXL via our new
 Human Malady Compendium 
Biological research products
for ACOXL
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Acyl-CoA Oxidase-Like1 2
Acyl-CoA Oxidase-Like Protein2 3
FLJ110421
Acyl-Coenzyme A Oxidase-Like1
Acyl-Coenzyme A Oxidase-Like Protein2
EC 1.3.3.-3

External Ids:    HGNC: 256211   Entrez Gene: 552892   Ensembl: ENSG000001530937   UniProtKB: Q9NUZ13   

Export aliases for ACOXL gene to outside databases

Previous GC identifers: GC02P111586 GC02P111206 GC02P104369 GC02P111587 GC02P111729


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACOXL gene promoter:
         E2F-1   E2F   Pax-5   FOXD3   FOXO3a   FOXO3   FOXO3b   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ACOXL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACOXL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

ACOXL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOXL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P112074:  view genomic region     (about GC identifiers)

Start:
111,490,150 bp from pter      End:
111,875,799 bp from pter
Size:
385,650 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACOXL_HUMAN, Q9NUZ1 (See protein sequence)
Recommended Name: Acyl-coenzyme A oxidase-like protein  
Size: 547 amino acids; 61795 Da
Cofactor: FAD (By similarity)
Sequence caution: Sequence=AAH22268.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=BAA91970.1;
Type=Erroneous initiation;
Secondary accessions: A2RRB7 B7WPB3 B7WPP7 Q53R27 Q53R31 Q53SC6 Q8TCE7
Alternative splicing: 3 isoforms:  Q9NUZ1-1   Q9NUZ1-2   Q9NUZ1-3   

Explore the universe of human proteins at neXtProt for ACOXL: NX_Q9NUZ1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NUZ1

  • ACOXL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001136279.1  
    ENSEMBL proteins: 
     ENSP00000374461   ENSP00000407761   ENSP00000343717   ENSP00000394701   ENSP00000387832  
     ENSP00000406774   ENSP00000409500   ENSP00000393823  

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    Uscn Proteins for ACOXL

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005777peroxisome IEA--


    ACOXL for ontologies           About GeneDecksing



    ACOXL Antibody Products: 
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    ThermoFisher Antibody for ACOXL

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    Uscn ELISAs and CLIAs for ACOXL


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACOXL for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR006090 Acyl-CoA_Oxase/DH_1
     IPR012258 Acyl-CoA_oxidase
     IPR009100 AcylCoA_DH/oxidase
     IPR006091 Acyl-CoA_Oxase/DH_cen-dom
     IPR002655 Acyl-CoA_oxidase_C

    Graphical View of Domain Structure for InterPro Entry Q9NUZ1

    ProtoNet protein and cluster: Q9NUZ1

    UniProtKB/Swiss-Prot: ACOXL_HUMAN, Q9NUZ1
    Similarity: Belongs to the acyl-CoA oxidase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Enzyme Number (IUBMB): EC 1.3.3.-1

    miRNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003995acyl-CoA dehydrogenase activity IEA--
    GO:0003997acyl-CoA oxidase activity IEA--
    GO:0016627oxidoreductase activity, acting on the CH-CH group of donors ----
    GO:0050660flavin adenine dinucleotide binding IEA--


    ACOXL for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ACOXL:
     Actin fiber cells  Increased HPV18 LCR reporter a 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACOXL

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process ----
    GO:0006635fatty acid beta-oxidation IEA--
    GO:0008150biological_process ND--


    ACOXL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACOXL

    10/33 HMDB Compounds for ACOXL (see all 33)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--
    Search CenterWatch for drugs/clinical trials and news about ACOXL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACOXL gene (4 alternative transcripts): 
    NM_001105516.2  NM_001142808.1  NM_018308.1  NM_001142807.1  

    Unigene Cluster for ACOXL:

    Acyl-CoA oxidase-like
    Hs.253320  [show with all ESTs]
    Unigene Representative Sequence: NM_001142807
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389811(uc021vmm.1 uc021vmn.1) ENST00000439055(uc010yxk.1)
    ENST00000340561 ENST00000448863 ENST00000461340 ENST00000417074 ENST00000433706
    ENST00000443586 ENST00000441974 ENST00000496981

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    hsa-miR-605
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    Additional cDNA sequence: 

    AK001904.1 AK300513.1 BC022268.1 BC131514.1 

    3 DOTS entries:

    DT.40128781  DT.100022202  DT.91669188 

    24/26 AceView cDNA sequences (see all 26):

    CK904788 BC022268 BM069702 BX282060 AI660659 AA015638 AA948246 BM069858 
    AA620835 AW630376 AU136508 CK904787 BF064226 AA927358 AK001904 BF064280 
    BM069609 BG619029 AI659238 NM_018308 BX118900 BX099110 AW627350 BI819505 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACOXL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCAGCACGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ACOXL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ACOXL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACOXL

    SOURCE GeneReport for Unigene cluster: Hs.253320
        SABiosciences Custom PCR Arrays for ACOXL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOXL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACOXL gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii acoxl1 acyl-Coenzyme A oxidase-like 64.77(n)
    65.78(a)
      569104  XM_692467.3  XP_697559.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACX21 acyl-coenzyme A oxidase 2 45.21(n)
    38.67(a)
      836635  NM_125910.5  NP_201316.1 
    rice
    (Oryza sativa)
    Liliopsida --
    acyl-coenzyme A oxidase, putative, expressed
    24(a)
    1 ↔ 1
    6(14503078-14511951)


    ENSEMBL Gene Tree for ACOXL (if available)
    TreeFam Gene Tree for ACOXL (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACOXL gene
    ACOX22  ACOX12  ACOX32  
    2 SIMAP similar genes for ACOXL using alignment to 6 protein entries:     ACOXL_HUMAN (see all proteins):
    ACOX3    ACOX1

    ACOXL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6247 NCBI SNPs in ACOXL are shown (see all 6247    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136261281,2
    C,--104735030(+) GCTGAC/TGAGCT 1 -- ds50012Minor allele frequency- T:0.03NA 122
    rs801050701,2
    --104735031(+) CTGACG/TAGCTA 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs757031641,2
    --104735403(+) AGTTAA/TGGGGA 1 -- nc-transcript-variant0--------
    rs1158573671,2
    C,F,--104736809(+) TGGGAC/TGTATG 1 -- nc-transcript-variant1Minor allele frequency- T:0.02WA 118
    rs170418611,2
    C,F,H,--104736973(+) TTAGCA/GAAATG 1 -- nc-transcript-variant12Minor allele frequency- G:0.05NA NS EA 1402
    rs1114014061,2
    --104736993(+) GTTCTG/ATTTCC 1 -- nc-transcript-variant1Minor allele frequency- A:0.50CSA 2
    rs133827911,2
    C,F,A,H,--104737327(+) TGCATC/TGTTTC 1 -- nc-transcript-variant13Minor allele frequency- T:0.04NA EA NS WA 1334
    rs761329941,2
    F,--104737531(+) CCATTC/TGTTTC 1 -- nc-transcript-variant1Minor allele frequency- T:0.04EA 120
    rs1123672541,2
    --104737675(+) GTTTCG/AGTTCA 1 -- nc-transcript-variant1Minor allele frequency- A:0.50CSA 2
    rs170405291,2
    C,F,H,--104738922(+) GGTATA/GAAATA 1 -- int117Minor allele frequency- G:0.07NA NS EA CSA WA 1774

    HapMap Linkage Disequilibrium report for ACOXL (111490150 - 111740150 bp, first 250kb of ACOXL)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ACOXL
         2 CNVs: 58905 58904
         2 Indels: 61806 40353

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACOXL for disorders           About GeneDecksing

    4 diseases for ACOXL:    About MalaCards
    acyl-coa dehydrogenase    chronic lymphocytic leukemia    lymphocytic leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: ACOXL (3 documents)

    Export disorders for ACOXL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACOXL gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ACOXL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. (PubMed id 22700719)1 Slager S.L....Houlston R.S. (2012)
    3. A genome-wide association study in Han Chinese identif ies multiple susceptibility loci for IgA nephropathy. (PubMed id 22197929)1 Yu X.Q....Liu J.J. (2012)
    4. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
    5. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    6. Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478)1 Okada Y....Kamatani N. (2011)
    7. Genetic susceptibility for chronic lymphocytic leukem ia among Chinese in Hong Kong. (PubMed id 20731705)1 Lan Q....Rothman N. (2010)
    8. Genetic susceptibility variants for chronic lymphocyt ic leukemia. (PubMed id 20332261)1 Slager S.L....Cerhan J.R. (2010)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55289 HGNC: 25621 AceView: ACOXL Ensembl:ENSG00000153093 euGenes: HUgn55289
    ECgene: ACOXL H-InvDB: ACOXL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACOXL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACOXL gene:
    Search GeneIP for patents involving ACOXL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
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