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Aliases for ACOX3 Gene

Aliases for ACOX3 Gene

  • Acyl-CoA Oxidase 3, Pristanoyl 2 3 5
  • Acyl-Coenzyme A Oxidase 3, Pristanoyl 2 3
  • Branched-Chain Acyl-CoA Oxidase 3 4
  • Pristanoyl-CoA Oxidase 3 4
  • BRCACOX 3 4
  • EC 1.3.3.6 4
  • BRCOX 4
  • PRCOX 4

External Ids for ACOX3 Gene

Previous GeneCards Identifiers for ACOX3 Gene

  • GC04M008343
  • GC04M008549
  • GC04M008561
  • GC04M008486
  • GC04M008368
  • GC04M008287

Summaries for ACOX3 Gene

Entrez Gene Summary for ACOX3 Gene

  • Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACOX3 Gene

ACOX3 (Acyl-CoA Oxidase 3, Pristanoyl) is a Protein Coding gene. Among its related pathways are Metabolism and cAMP signaling pathway. GO annotations related to this gene include receptor binding and oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is ACOX1.

UniProtKB/Swiss-Prot for ACOX3 Gene

  • Oxidizes the CoA-esters of 2-methyl-branched fatty acids.

Gene Wiki entry for ACOX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOX3 Gene

Genomics for ACOX3 Gene

Regulatory Elements for ACOX3 Gene

Promoters for ACOX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACOX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOX3 Gene

Chromosome:
4
Start:
8,366,263 bp from pter
End:
8,440,725 bp from pter
Size:
74,463 bases
Orientation:
Minus strand

Genomic View for ACOX3 Gene

Genes around ACOX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOX3 Gene

Proteins for ACOX3 Gene

  • Protein details for ACOX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15254-ACOX3_HUMAN
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 3
    Protein Accession:
    O15254
    Secondary Accessions:
    • Q96AJ8

    Protein attributes for ACOX3 Gene

    Size:
    700 amino acids
    Molecular mass:
    77629 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACOX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOX3 Gene

Proteomics data for ACOX3 Gene at MOPED

Post-translational modifications for ACOX3 Gene

  • Ubiquitination at Lys 265 and Lys 291
  • Modification sites at PhosphoSitePlus

Other Protein References for ACOX3 Gene

Antibody Products

No data available for DME Specific Peptides for ACOX3 Gene

Domains & Families for ACOX3 Gene

Suggested Antigen Peptide Sequences for ACOX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15254

UniProtKB/Swiss-Prot:

ACOX3_HUMAN :
  • Belongs to the acyl-CoA oxidase family.
Family:
  • Belongs to the acyl-CoA oxidase family.
genes like me logo Genes that share domains with ACOX3: view

No data available for Gene Families for ACOX3 Gene

Function for ACOX3 Gene

Molecular function for ACOX3 Gene

GENATLAS Biochemistry:
branched-chain acyl-CoA oxidase 3,peroxisomal,acting on the CoA-esters of pristanic acid and straight chain mono-and dicarboxy fatty acids,expression below detection limit in man,extremely weakly expressed in liver,may be expressed under special conditions and tissues so far not examined
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Oxidizes the CoA-esters of 2-methyl-branched fatty acids.

Enzyme Numbers (IUBMB) for ACOX3 Gene

Gene Ontology (GO) - Molecular Function for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IBA --
GO:0009055 electron carrier activity IBA --
GO:0050660 flavin adenine dinucleotide binding IEA,IBA --
GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor IBA --
genes like me logo Genes that share ontologies with ACOX3: view
genes like me logo Genes that share phenotypes with ACOX3: view

Animal Model Products

miRNA for ACOX3 Gene

miRTarBase miRNAs that target ACOX3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOX3 Gene

Localization for ACOX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOX3 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOX3 Gene COMPARTMENTS Subcellular localization image for ACOX3 gene
Compartment Confidence
peroxisome 5
mitochondrion 3
cytosol 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACOX3: view

Pathways & Interactions for ACOX3 Gene

genes like me logo Genes that share pathways with ACOX3: view

UniProtKB/Swiss-Prot O15254-ACOX3_HUMAN

  • Pathway: Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Interacting Proteins for ACOX3 Gene

Gene Ontology (GO) - Biological Process for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0055088 lipid homeostasis IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ACOX3: view

No data available for SIGNOR curated interactions for ACOX3 Gene

Drugs & Compounds for ACOX3 Gene

(5) Drugs for ACOX3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
myristoyl-coa Experimental Pharma 0
Propionyl-CoA Experimental Pharma 0
Hydrogen peroxide Pharma 46

(51) Additional Compounds for ACOX3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOX3: view

Transcripts for ACOX3 Gene

Unigene Clusters for ACOX3 Gene

Acyl-CoA oxidase 3, pristanoyl:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: -
SP5: - -
SP6: -
SP7:
SP8:

ExUns: 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ACOX3 Gene

GeneLoc Exon Structure for
ACOX3
ECgene alternative splicing isoforms for
ACOX3

Expression for ACOX3 Gene

mRNA expression in normal human tissues for ACOX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACOX3 Gene

This gene is overexpressed in Cervix (18.9), Breast (14.2), and Bone (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOX3 Gene



SOURCE GeneReport for Unigene cluster for ACOX3 Gene Hs.479122

genes like me logo Genes that share expression patterns with ACOX3: view

Protein tissue co-expression partners for ACOX3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACOX3 Gene

Orthologs for ACOX3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOX3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACOX3 35
  • 78.95 (n)
  • 79.43 (a)
ACOX3 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOX3 35
  • 79.14 (n)
  • 76.71 (a)
ACOX3 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acox3 35
  • 76.19 (n)
  • 73.43 (a)
Acox3 16
Acox3 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACOX3 35
  • 99.04 (n)
  • 99.24 (a)
ACOX3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acox3 35
  • 76.14 (n)
  • 74 (a)
oppossum
(Monodelphis domestica)
Mammalia ACOX3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACOX3 35
  • 65.41 (n)
  • 65.31 (a)
ACOX3 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOX3 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acox3 35
  • 66.33 (n)
  • 68.31 (a)
zebrafish
(Danio rerio)
Actinopterygii acox3 35
  • 65.46 (n)
  • 65.41 (a)
wufj81d02 35
acox3 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4390 35
fruit fly
(Drosophila melanogaster)
Insecta CG17544 37
  • 42 (a)
CG9527 37
  • 42 (a)
CG9527 35
  • 52.27 (n)
  • 44.69 (a)
CG17544 36
  • 43 (a)
OneToMany
CG9527 36
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007958 35
  • 50.97 (n)
  • 42.6 (a)
worm
(Caenorhabditis elegans)
Secernentea F58F9.7 37
  • 40 (a)
F58F9.7 35
  • 47.73 (n)
  • 42.08 (a)
F58F9.7 36
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POX1 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACX6 35
  • 46.69 (n)
  • 38.03 (a)
rice
(Oryza sativa)
Liliopsida Os06g0354500 35
  • 46.25 (n)
  • 38.42 (a)
Species with no ortholog for ACOX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOX3 Gene

ENSEMBL:
Gene Tree for ACOX3 (if available)
TreeFam:
Gene Tree for ACOX3 (if available)

Paralogs for ACOX3 Gene

Paralogs for ACOX3 Gene

(3) SIMAP similar genes for ACOX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOX3: view

Variants for ACOX3 Gene

Sequence variations from dbSNP and Humsavar for ACOX3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs12513296 - 8,416,421(+) CCAGC(G/T)CCTTC nc-transcript-variant, reference, missense
rs13434465 - 8,389,221(+) CTGGT(C/T)AAGGA nc-transcript-variant, reference, missense
rs7809 -- 8,366,706(+) CCCAC(A/G)GCGCA nc-transcript-variant, utr-variant-3-prime
rs12701 -- 8,366,733(+) ATCTG(A/C)ATTTC nc-transcript-variant, utr-variant-3-prime
rs827000 -- 8,367,142(+) CTAGA(C/T)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOX3 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
dgv5455n71 CNV Loss 21882294
nsv470013 CNV Gain 18288195
nsv878604 CNV Gain 21882294
nsv878605 CNV Loss 21882294
nsv4223 CNV Insertion 18451855
dgv5458n71 CNV Loss 21882294
nsv526508 CNV Loss 19592680
nsv461220 CNV Loss 19166990
nsv524994 CNV Loss 19592680
dgv5459n71 CNV Loss 21882294
esv1005399 CNV Deletion 20482838
nsv470014 CNV Loss 18288195
esv2148081 CNV Deletion 18987734
esv2727113 CNV Deletion 23290073
esv2676067 CNV Deletion 23128226
esv1516082 CNV Deletion 17803354
nsv829854 CNV Gain+Loss 17160897
esv2727114 CNV Deletion 23290073

Variation tolerance for ACOX3 Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOX3 Gene

HapMap Linkage Disequilibrium report
ACOX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOX3 Gene

Disorders for ACOX3 Gene

Relevant External Links for ACOX3

Genetic Association Database (GAD)
ACOX3
Human Genome Epidemiology (HuGE) Navigator
ACOX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOX3

No disorders were found for ACOX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOX3 Gene

Publications for ACOX3 Gene

  1. Evidence for the existence of a pristanoyl-CoA oxidase gene in man. (PMID: 9271077) Vanhooren J.C.T. … van Veldhoven P.P. (Biochem. J. 1997) 2 3 4 23 67
  2. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. (PMID: 15599942) Zha S. … Isaacs W.B. (Prostate 2005) 3 23
  3. The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney. (PMID: 8387517) Vanhove G.F. … Mannaerts G.P. (J. Biol. Chem. 1993) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PMID: 21659360) Wade R. … Houlston R.S. (Haematologica 2011) 3

Products for ACOX3 Gene

Sources for ACOX3 Gene

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