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Aliases & Descriptions for ACOX3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases BRCACox 3 BRCOX 3 EC 1.3.3.6 3 PRCOX 3
Descriptions Branched-chain acyl-CoA oxidase 3 Pristanoyl-CoA oxidase 3 acyl-Coenzyme A oxidase 3 2 acyl-Coenzyme A oxidase 3, pristanoyl 2
Search outside databases for aliases for ACOX3 genePrevious GC identifers: GC04M008343 GC04M008549 GC04M008561
Summaries for ACOX3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ACOX3 : Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in thedesaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the humangene is expressed in very low amounts in liver such that its mRNA was undetectable by routineNorthern-blot analysis or its product by immunoblotting or by enzyme activity measurements.However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminaltripeptide S-K-L was isolated and is thought to be expressed under special conditions such asspecific developmental stages or in a tissue specific manner in tissues that have not yet beenexamined. [provided by RefSeq] UniProtKB/Swiss-Prot: ACOX3_HUMAN, O15254 Function : Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity)
Gene Wiki entry for ACOX3
Genomic Location for ACOX3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ACOX3 gene Entrez Gene cytogenetic band: 4p15.3 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p15.3 ACOX3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M008486:
(about GC identifiers )
Start:
8,418,909 bp from pter
End:
8,493,352 bp from pter
Size:
74,444 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_006051.17 Proteins for ACOX3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ACOX3_HUMAN, O15254 (See
protein sequence )Recommended Name: Peroxisomal acyl-coenzyme A oxidase 3 Size : 700 amino acids; 77629 Da
Cofactor : FAD (By similarity)
Subcellular location : Peroxisome (Potential)
Secondary accessions : Q96AJ8Alternative splicing : 2 isoforms : O15254-1 O15254-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001095137.1 NP_003492.2 ENSEMBL proteins: ENSP00000348775 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for ACOX3: Assays for ACOX3:
Protein
Domains/ Families for ACOX3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O15254 ProtoNet protein and cluster: O15254
1 Blocks protein family : IPB002655 Acyl-CoA oxidase UniProtKB/Swiss-Prot: ACOX3_HUMAN, O15254 Similarity : Belongs to the acyl-CoA oxidase family
Gene Function for ACOX3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_003501 Applied Biosystems Silencer ® siRNAs for ACOX3 Sigma-Aldrich siRNA for ACOX3 Sigma-Aldrich shRNA for ACOX3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001101667                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001101667                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001101667  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003501 UniProtKB/Swiss-Prot: ACOX3_HUMAN, O15254 Function : Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity)Catalytic activity : Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)Enzyme Number (IUBMB): EC 1.3.3.6
Genatlas biochemistry entry for ACOX3 :branched-chain acyl-CoA oxidase 3,peroxisomal,acting on the CoA-esters of pristanic acid andstraight chain mono-and dicarboxy fatty acids,expression below detection limit in man,extremelyweakly expressed in liver,may be expressed under special conditions and tissues so far notexamined 4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for ACOX3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ACOX3 (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: ACOX3_HUMAN, O15254 Pathway : Lipid metabolism; peroxisomal fatty acid beta-oxidation
5/36 Interacting proteins for ACOX3 (O15254 2 ENSP00000348775 3 ) via UniProtKB, MINT, and/or STRING (see all 36
)About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for ACOX3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ACOX3 6 Novoseek chemical compound relationships for ACOX3 gene
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Transcripts for ACOX3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_003501 Sigma-Aldrich siRNA for ACOX3 Sigma-Aldrich shRNA for ACOX3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001101667 NM_003501
REFSEQ mRNAs for ACOX3 gene (2 alternative transcripts): NM_001101667.1 NM_003501.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001101667 NM_003501
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001101667                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001101667                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001101667  
Additional cDNA sequence: AK225080.1 AK313242.1 BC017053.1 BX640768.1 CR590418.1 CR609446.1 Y11411.1
10 DOTS entries : DT.100742019 DT.315013 DT.95141073 DT.97841659 DT.101966593 DT.95261316 DT.75102844 DT.86848005 DT.91740564 DT.95155153
24/141 AceView cDNA sequences (see all 141
):BF724168 Z45527 BX364074 CR609446 BM456773 AW402036 CA306669 BQ436455 CA438485 BU857907 BE467143 AU132016 Z40378 AI436007 AI571140 BF437051 F09801 BF055976 AI435950 BM682926 AA864971 BC017053 BM773520 CF132142
highest scoring ESTs for ACOX3 :AI992213 BC017053 BE888898 BG911209 BI916811 BM837705 Y11411 AA007625 AA007662 AA207238
Unigene Cluster for ACOX3: Acyl-Coenzyme A oxidase 3, pristanoyl Hs.479122 [show with all ESTs ] Unigene Representative Sequence: BX640768 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ACOX3 (see all 8
) ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · SP1 :                                     -       -   -         SP2 :     -   -   -                             -       -   -   -       SP3 :                                                     SP4 :           -                                           SP5 :                                           -   -        
ExUns: 21b · 21c SP1 :     SP2 :     SP3 :     SP4 :     SP5 :    
About this scheme ECgene alternative splicing isoforms for ACOX3 1 Ensembl transcript including schematic representation : ENST00000356406
Expression for ACOX3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ACOX3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ACOX3 1 / 2 / 3
7 probe-sets matching ACOX3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCTACCTGATSOURCE GeneReport for Unigene cluster: Hs.479122 Expression variation in blood from EXPOLDB for ACOX3
Orthologs for ACOX3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
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Gene Trees according to Ensembl )
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Orthologs for ACOX3 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for ACOX3 ENSEMBL Gene Tree for ACOX3 Paralogs for ACOX3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ACOX3 gene ACOX2 2 ACOX1 2 ACOXL 2
SNPs/Variants for ACOX3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ACOX3 (up to first 250kb)
Disorders & Mutations for ACOX3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 603402 1 Novoseek disease relationship for ACOX3 gene
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Medical News for ACOX3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ACOX3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/21 PubMed articles for ACOX3 gene (see all 21
):
Search for ACOX3
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ACOX3
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ACOX3
(According to HUGE )
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Specialized Databases showing ACOX3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ACOX3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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