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Aliases for ACOX3 Gene

Aliases for ACOX3 Gene

  • Acyl-CoA Oxidase 3, Pristanoyl 2 3
  • Acyl-Coenzyme A Oxidase 3, Pristanoyl 2 3
  • Branched-Chain Acyl-CoA Oxidase 3 4
  • Pristanoyl-CoA Oxidase 3 4
  • BRCACox 3 4
  • Peroxisomal Acyl-Coenzyme A Oxidase 3 3
  • EC 1.3.3.6 4
  • BRCOX 4
  • PRCOX 4

External Ids for ACOX3 Gene

Summaries for ACOX3 Gene

Entrez Gene Summary for ACOX3 Gene

  • Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACOX3 Gene

ACOX3 (Acyl-CoA Oxidase 3, Pristanoyl) is a Protein Coding gene. Diseases associated with ACOX3 include mutism. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include receptor binding and acyl-CoA dehydrogenase activity. An important paralog of this gene is ACOX1.

UniProtKB/Swiss-Prot for ACOX3 Gene

  • Oxidizes the CoA-esters of 2-methyl-branched fatty acids.

Gene Wiki entry for ACOX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOX3 Gene

Genomics for ACOX3 Gene

Genomic Location for ACOX3 Gene

Start:
8,366,282 bp from pter
End:
8,440,725 bp from pter
Size:
74,444 bases
Orientation:
Minus strand

Genomic View for ACOX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOX3 Gene

Regulatory Elements for ACOX3 Gene

Proteins for ACOX3 Gene

  • Protein details for ACOX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15254-ACOX3_HUMAN
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 3
    Protein Accession:
    O15254
    Secondary Accessions:
    • Q96AJ8

    Protein attributes for ACOX3 Gene

    Size:
    700 amino acids
    Molecular mass:
    77629 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACOX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOX3 Gene

Proteomics data for ACOX3 Gene at MOPED

Post-translational modifications for ACOX3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys265 and Lys291

Other Protein References for ACOX3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ACOX3 Gene

Domains for ACOX3 Gene

UniProtKB/Swiss-Prot:

ACOX3_HUMAN
Family:
  • Belongs to the acyl-CoA oxidase family.:
    • O15254
genes like me logo Genes that share domains with ACOX3: view

No data available for Gene Families for ACOX3 Gene

Function for ACOX3 Gene

Molecular function for ACOX3 Gene

GENATLAS Biochemistry: branched-chain acyl-CoA oxidase 3,peroxisomal,acting on the CoA-esters of pristanic acid and straight chain mono-and dicarboxy fatty acids,expression below detection limit in man,extremely weakly expressed in liver,may be expressed under special conditions and tissues so far not examined
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)
UniProtKB/Swiss-Prot Function: Oxidizes the CoA-esters of 2-methyl-branched fatty acids.

Enzyme Numbers (IUBMB) for ACOX3 Gene

Gene Ontology (GO) - Molecular Function for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003995 acyl-CoA dehydrogenase activity IEA --
GO:0003997 acyl-CoA oxidase activity --
GO:0005102 receptor binding IPI 20178365
GO:0016402 pristanoyl-CoA oxidase activity TAS --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors --
genes like me logo Genes that share ontologies with ACOX3: view

Phenotypes for ACOX3 Gene

GenomeRNAi human phenotypes for ACOX3:
genes like me logo Genes that share phenotypes with ACOX3: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACOX3 Gene

Localization for ACOX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOX3 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOX3 Gene COMPARTMENTS Subcellular localization image for ACOX3 gene
Compartment Confidence
peroxisome 4
cytosol 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IDA 8993592
GO:0005782 peroxisomal matrix TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACOX3: view

Pathways for ACOX3 Gene

genes like me logo Genes that share pathways with ACOX3: view

UniProtKB/Swiss-Prot O15254-ACOX3_HUMAN

  • Pathway: Lipid metabolism; peroxisomal fatty acid beta-oxidation

Interacting Proteins for ACOX3 Gene

Gene Ontology (GO) - Biological Process for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process --
GO:0006635 fatty acid beta-oxidation --
GO:0008152 metabolic process --
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase TAS --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with ACOX3: view

Compounds for ACOX3 Gene

(42) HMDB Compounds for ACOX3 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(6) Novoseek inferred chemical compound relationships for ACOX3 Gene

Compound -log(P) Hits PubMed IDs
pristanic acid 95.5 3
acyl-coa 83.8 3
phytanic acid 83.2 1
tripeptide 54.1 1
sterol 42.5 2
genes like me logo Genes that share compounds with ACOX3: view

Transcripts for ACOX3 Gene

Unigene Clusters for ACOX3 Gene

Acyl-CoA oxidase 3, pristanoyl:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: -
SP5: - -
SP6: -
SP7:
SP8:

ExUns: 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ACOX3 Gene

GeneLoc Exon Structure for
ACOX3
ECgene alternative splicing isoforms for
ACOX3

Expression for ACOX3 Gene

mRNA expression in normal human tissues for ACOX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOX3 Gene

SOURCE GeneReport for Unigene cluster for ACOX3 Gene Hs.479122

genes like me logo Genes that share expressions with ACOX3: view

Orthologs for ACOX3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOX3 36
  • 99.04 (n)
  • 99.24 (a)
ACOX3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACOX3 36
  • 78.95 (n)
  • 79.43 (a)
ACOX3 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOX3 36
  • 79.14 (n)
  • 76.71 (a)
ACOX3 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acox3 36
  • 76.19 (n)
  • 73.43 (a)
Acox3 16
Acox3 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACOX3 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acox3 36
  • 76.14 (n)
  • 74 (a)
chicken
(Gallus gallus)
Aves ACOX3 36
  • 65.41 (n)
  • 65.31 (a)
ACOX3 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOX3 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acox3 36
  • 66.33 (n)
  • 68.31 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4390 36
zebrafish
(Danio rerio)
Actinopterygii acox3 36
  • 65.46 (n)
  • 65.41 (a)
acox3 37
  • 63 (a)
OneToOne
wufj81d02 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007958 36
  • 50.97 (n)
  • 42.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17544 37
  • 43 (a)
OneToMany
CG9527 36
  • 52.27 (n)
  • 44.69 (a)
CG9527 37
  • 42 (a)
OneToMany
CG17544 38
  • 42 (a)
CG9527 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea F58F9.7 36
  • 47.73 (n)
  • 42.08 (a)
F58F9.7 37
  • 40 (a)
OneToOne
F58F9.7 38
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POX1 37
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACX6 36
  • 46.69 (n)
  • 38.03 (a)
rice
(Oryza sativa)
Liliopsida Os06g0354500 36
  • 46.25 (n)
  • 38.42 (a)
Species with no ortholog for ACOX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOX3 Gene

ENSEMBL:
Gene Tree for ACOX3 (if available)
TreeFam:
Gene Tree for ACOX3 (if available)

Paralogs for ACOX3 Gene

Paralogs for ACOX3 Gene

Selected SIMAP similar genes for ACOX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOX3: view

Variants for ACOX3 Gene

Sequence variations from dbSNP and Humsavar for ACOX3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs7809 -- 8,366,706(+) CCCAC(A/G)GCGCA utr-variant-3-prime
rs12701 -- 8,366,733(+) ATCTG(A/C)ATTTC utr-variant-3-prime
rs708243 -- 8,366,312(+) ACTGG(C/T)GGCAG utr-variant-3-prime
rs708244 -- 8,366,877(+) TCCGG(C/T)GTGTT utr-variant-3-prime
rs735441 -- 8,369,143(+) AAGGC(A/G)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOX3 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
dgv5455n71 CNV Loss 21882294
nsv470013 CNV Gain 18288195
nsv878604 CNV Gain 21882294
nsv878605 CNV Loss 21882294
nsv4223 CNV Insertion 18451855
dgv5458n71 CNV Loss 21882294
nsv526508 CNV Loss 19592680
nsv461220 CNV Loss 19166990
nsv524994 CNV Loss 19592680
dgv5459n71 CNV Loss 21882294
esv1005399 CNV Deletion 20482838
nsv470014 CNV Loss 18288195
esv2148081 CNV Deletion 18987734
esv2727113 CNV Deletion 23290073
esv2676067 CNV Deletion 23128226
esv1516082 CNV Deletion 17803354
nsv829854 CNV Gain+Loss 17160897
esv2727114 CNV Deletion 23290073

Relevant External Links for ACOX3 Gene

HapMap Linkage Disequilibrium report
ACOX3

Disorders for ACOX3 Gene

(1) MalaCards Diseases for ACOX3 Gene

Search for ACOX3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ACOX3 Gene

(1) Novoseek inferred disease relationships for ACOX3 Gene

Disease -log(P) Hits PubMed IDs
zellweger syndrome 79.9 2

Relevant External Links for ACOX3

Genetic Association Database (GAD)
ACOX3
Human Genome Epidemiology (HuGE) Navigator
ACOX3
genes like me logo Genes that share disorders with ACOX3: view

No data available for UniProtKB/Swiss-Prot for ACOX3 Gene

Publications for ACOX3 Gene

  1. Evidence for the existence of a pristanoyl-CoA oxidase gene in man. (PMID: 9271077) Vanhooren J.C.T. … van Veldhoven P.P. (Biochem. J. 1997) 2 3 4 23
  2. The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney. (PMID: 8387517) Vanhove G.F. … Mannaerts G.P. (J. Biol. Chem. 1993) 3 23
  3. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. (PMID: 15599942) Zha S. … Isaacs W.B. (Prostate 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 49

Products for ACOX3 Gene

Sources for ACOX3 Gene

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