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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACOX2 Gene

protein-coding GIFtS: 57
GCID: GC03M058465

acyl-CoA oxidase 2, branched chain

(Previous names: acyl-Coenzyme A oxidase 2, branched chain )

Explore 5 diseases affiliated with
ACOX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acyl-CoA Oxidase 2, Branched Chain¹ ²		3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA Oxidase² ³
THCCox¹ ² ³		THCA-CoA Oxidase² ³
BRCACOX¹ ² ⁵		BCOX²
BRCOX¹ ²		Peroxisomal Acyl-Coenzyme A Oxidase 2²
Acyl-Coenzyme A Oxidase 2, Branched Chain¹ ²		Peroxisomal Branched Chain Acyl-CoA Oxidase²
Trihydroxycoprostanoyl-CoA Oxidase² ³		EC 1.17.99.3³
3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA 24-Hydroxylase² ³

External Ids:	HGNC: 120¹	Entrez Gene: 8309²	Ensembl: ENSG00000168306⁷	OMIM: 601641⁵	UniProtKB: Q99424³

Export aliases for ACOX2 gene to outside databases

Previous GC identifers: GC03M057354 GC03M057859 GC03M058345 GC03M058448

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACOX2:

The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which

is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of

this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger

syndrome, severe mental retardation, and death in children. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: ACOX2_HUMAN, Q99424

Function: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACOX2 gene promoter:
RFX1 SREBP-1c Pax-2 Olf-1 Pax-2a SREBP-1b C/EBPalpha c-Ets-1 Pax-2b SREBP-1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACOX2 promoter sequence

Search SABiosciences Chromatin IP Primers for ACOX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACOX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3 Ensembl cytogenetic band: 3p14.3 HGNC cytogenetic band: 3p14.3

ACOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOX2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M058465: view genomic region (about GC identifiers)

Start:	58,490,863 bp from pter	End:	58,523,046 bp from pter
Size:	32,184 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACOX2_HUMAN, Q99424 (See protein sequence)

Recommended Name: Peroxisomal acyl-coenzyme A oxidase 2

Size: 681 amino acids; 76827 Da

Cofactor: FAD (By similarity)

Subunit: Heterodimer (By similarity)

Subcellular location: Peroxisome

Secondary accessions: A6NF16 B2R8U5

Explore the universe of human proteins at neXtProt for ACOX2: NX_Q99424

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99424

ACOX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003491.1

ENSEMBL proteins:

ENSP00000418562 ENSP00000307697 ENSP00000417877 ENSP00000418515 ENSP00000419133

ENSP00000419927

Reactome Protein details: Q99424
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACOX2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005777	peroxisome	IDA	8943006
GO:0005782	peroxisomal matrix	TAS	--

ACOX2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ACOX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACOX2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR012258 Acyl-CoA_oxidase

IPR009100 AcylCoA_DH/oxidase

IPR013786 AcylCoA_DH/ox_N

IPR006091 Acyl-CoA_Oxase/DH_cen-dom

IPR002655 Acyl-CoA_oxidase_C

Graphical View of Domain Structure for InterPro Entry Q99424

ProtoNet protein and cluster: Q99424

1 Blocks protein family: IPB002655 Acyl-CoA oxidase

UniProtKB/Swiss-Prot: ACOX2_HUMAN, Q99424

Similarity: Belongs to the acyl-CoA oxidase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACOX2_HUMAN, Q99424

Function: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids

Catalytic activity: (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor =

(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor

Genatlas biochemistry entry for ACOX2:

peroxisomal acyl-CoA oxidase,acting on the CoA-esters of bile acid intermediates and pristanic acid ,expressed in liver

and extrahepatic tissues,about null activity in the Zellweger cerebrohepatorenal syndrome

Enzyme Number (IUBMB): EC 1.17.99.3¹

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOX2

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003995	acyl-CoA dehydrogenase activity	IEA	--
GO:0003997	acyl-CoA oxidase activity	TAS	--
GO:0005102	receptor binding	IPI	--
GO:0005504	fatty acid binding	--	--
GO:0016402	pristanoyl-CoA oxidase activity	TAS	--

ACOX2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of bile acids and bile salts

Synthesis of bile acids and bile salts	1.00	Bile acid and bile salt metabolism	0.70
Primary bile acid biosynthesis	0.84	bile acid biosynthesis, neutral pathway	0.52
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.79

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Peroxisomal lipid metabolism

Peroxisomal lipid metabolism

1.00

Beta-oxidation of pristanoyl-CoA

0.40

Peroxisome

Peroxisome

1.00

PPAR signaling pathway

PPAR signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for ACOX2

bile acid biosynthesis, neutral pathway

5/7 Reactome Pathways for ACOX2 (see all 7)

	Beta-oxidation of pristanoyl-CoA
	Bile acid and bile salt metabolism
	Metabolism
	Peroxisomal lipid metabolism
	Synthesis of bile acids and bile salts

4 Kegg Pathways (Kegg details for ACOX2):

	Primary bile acid biosynthesis
	Metabolic pathways
	PPAR signaling pathway
	Peroxisome

ACOX2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ACOX2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ACOX2 (ENSP00000307697⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AMACR	ENSP00000334424⁴	STRING: ENSP00000334424
HSD17B4	ENSP00000256216⁴	STRING: ENSP00000256216

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006631	fatty acid metabolic process	--	--
GO:0006635	fatty acid beta-oxidation	--	--
GO:0006699	bile acid biosynthetic process	TAS	--
GO:0008206	bile acid metabolic process	TAS	--
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	TAS	--

ACOX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ACOX2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACOX2

10/35 HMDB Compounds for ACOX2 (see all 35) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Acrylyl-CoA	Acryloyl coenzyme A (see all 14)	5776-58-9	--

4 Novoseek chemical compound relationships for ACOX2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pristanic acid	93.1	1	9803880 (1)
acyl-coa	85.5	14	11330072 (1), 9271077 (1), 10709653 (1), 8943006 (1) (see all 9)
tripeptide	62.9	1	8947475 (1)
sterol	52.3	4	9803880 (1), 10379198 (1)

Search CenterWatch for drugs/clinical trials and news about ACOX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACOX2 gene:

NM_003500.3

Unigene Cluster for ACOX2:

Acyl-CoA oxidase 2, branched chain

Hs.444959 [show with all ESTs]

Unigene Representative Sequence: BC033517

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000481527 ENST00000467738 ENST00000459701 ENST00000302819(uc003dkl.3)

ENST00000460921 ENST00000489472 ENST00000459888 ENST00000466810 ENST00000492530

ENST00000474098 ENST00000475143 ENST00000466689 ENST00000480791

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACOX2

Additional cDNA sequence:

AK313512.1 BC033517.1 BC047700.1 X95190.1

12 DOTS entries:

DT.214407 DT.95170707 DT.100777087 DT.40262032 DT.92426992 DT.100712743 DT.100777083 DT.100777089

DT.120884000 DT.120884022 DT.91678918 DT.95170708

24/104 AceView cDNA sequences (see all 104):

AL709699 BE896858 NM_003500 BQ887020 BF725326 BC033517 BU502674 C00931

BG563010 BF591987 BU542267 BG545036 BC047700 CA487428 BQ268819 BU952554

BF063434 CB163506 BQ067664 BU951118 BU631122 BM973931 BI763985 BM984228

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ACOX2 (see all 11) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	^	12a	·
SP1:					-		-						-										-						-										-				-
SP2:																	-		-				-						-
SP3:
SP4:
SP5:																																					-		-				-

ExUns:	12b	^	13	^	14	^	15	^	16	^	17
SP1:			-
SP2:
SP3:			-
SP4:
SP5:

ECgene alternative splicing isoforms for ACOX2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACOX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATAATGGT

About this image

ACOX2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ACOX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACOX2

SOURCE GeneReport for Unigene cluster: Hs.444959

UniProtKB/Swiss-Prot: ACOX2_HUMAN, Q99424

Tissue specificity: Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and

pancreas. Most abundant in heart, liver and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including ACOX2:

Fatty Acid Metabolism in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOX2 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACOX2¹	acyl-CoA oxidase 2, branched chain	63.17(n) 58.51(a)		416068 XM_414406.3 XP_414406.1
lizard (Anolis carolinensis)	Reptilia	ACOX2⁶	--	55(a)	1 ↔ 1	2(187146309-187177284)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16340²	Xenopus laevis transcribed sequence with weak similarity to protein spQ99424 (H.sapiens) CAO2_HUMAN Acyl-coenzyme A oxidase 2, peroxisomal (Branched-chain acyl-CoA oxidase) (BRCACox) (Trihydroxycoprostanoyl-CoA oxidase) (THCCox) (THCA-CoA oxidase) less	72.25(n)		BQ386896.1
worm (Caenorhabditis elegans)	Secernentea	F08A8.1³	ACYL-COENZYME A OXIDASE, PEROXISOMAL (EC 1.3.3.6) (PALMITOYL-COA OXIDASE) (AOX) less	37(a) (best of 5)		I(12946613-12950171) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ACX5⁶ ACX1⁶ (see all 3)	peroxisomal acyl-coenzyme A oxidase 1 (see all 3)	36(a) 36(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(14999754-15003066) 4(9424633-9428895)
rice (Oryza sativa)	Liliopsida	-- --	acyl-coenzyme A oxidase, putative, expressed	36(a) 25(a)	1 ↔ many possible ortholog	6(226701-231808) 11(22888019-22892188)

ENSEMBL Gene Tree for ACOX2 (if available)
TreeFam Gene Tree for ACOX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ACOX2 gene

ACOX1² ACOX3² ACOXL²

2 SIMAP similar genes for ACOX2 using alignment to 6 protein entries: ACOX2_HUMAN (see all proteins):

ACOX3 ACOX1

ACOX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75546619^1,2	C,	--	58490418(+)	`TGGCTG/ACTTTT`	1	--	ds500¹		1		WA	2
rs138914838^1,2		--	58490489(+)	`ACCTCA/GTGATC`	1	--	ds500¹		0	--	--	--	--
rs142815004^1,2		--	58490495(+)	`TGATCC/TACCTG`	1	--	ds500¹		0	--	--	--	--
rs189846193^1,2		--	58490533(+)	`CAGGCA/GTGAGA`	1	--	ds500¹		0	--	--	--	--
rs182429731^1,2		--	58490586(+)	`CTGGTC/TTCGAA`	1	--	ds500¹		0	--	--	--	--
rs4681858^1,2	C,F,A,H,	--	58490665(+)	`CGCCCC/TACTGG`	1	--	ds500¹		24		NS EA NA CSA WA	2485
rs75857311^1,2	C,	--	58490887(+)	`GTTGCA/GTATAT`	1	--	ut3¹		2		NA	122
rs186380643^1,2	C,	--	58490945(+)	`TGTTGA/GTTATT`	1	--	ut3¹		0	--	--	--	--
rs191136907^1,2	C,	--	58491013(+)	`GTTCTC/TCTGTT`	2	K E	mis¹		0	--	--	--	--
rs200767808^1,2		--	58491031(+)	`AGAAAC/TGCATT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ACOX2 (58490863 - 58523046 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ACOX2
1 CNV: 36157

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ACOX2 for disorders           About GeneDecksing

OMIM gene information: 601641    OMIM disorders: --

5 diseases for ACOX2:    About MalaCards

zellweger syndrome acyl-coa dehydrogenase pseudoneonatal adrenoleukodystrophy adrenoleukodystrophy

hepatoblastoma

Human Genome Epidemiology (HuGE) Navigator: ACOX2 (1 document)

Export disorders for ACOX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ACOX2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with ACOX2)

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Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger's syndrome. (PubMed id 8943006)^{1, 2, 3, 9} Baumgart E....Van Veldhoven P.P. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Assignment of the human peroxisomal branched-chain acyl-CoA oxidase gene to chromosome 3p21.1-p14.2 by rodent/human somatic cell hybridization. (PubMed id 9070889)^{1, 3} Moghrabi N.N....Bennett M.J. (1997)
Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver. (PubMed id 2079609)^{1, 9} Casteels M....Mannaerts G.P. (1990)
The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney. (PubMed id 8387517)^{1, 9} Vanhove G.F....Mannaerts G.P. (1993)
Identification of ACOX2 as a shared genetic risk fact or for preeclampsia and cardiovascular disease. (PubMed id 21343950)¹ Johansson A....Blangero J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
Biochemistry of mammalian peroxisomes revisited. (PubMed id 16756494)¹ Wanders R.J. and Waterham H.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8309	HGNC: 120	AceView: ACOX2	Ensembl:ENSG00000168306	euGenes: HUgn8309
ECgene: ACOX2	Kegg: 8309	H-InvDB: ACOX2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ACOX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACOX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACOX2 gene:
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acyl-CoA oxidase 2, branched chain

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ACOX2 Gene

acyl-CoA oxidase 2, branched chain

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