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Aliases for ACOX2 Gene

Aliases for ACOX2 Gene

  • Acyl-CoA Oxidase 2, Branched Chain 2 3
  • 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA 24-Hydroxylase 2 3 4
  • Trihydroxycoprostanoyl-CoA Oxidase 2 3 4
  • 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA Oxidase 3 4
  • Acyl-Coenzyme A Oxidase 2, Branched Chain 2 3
  • THCA-CoA Oxidase 3 4
  • BRCACox 3 6
  • THCCox 3 4
  • Peroxisomal Branched Chain Acyl-CoA Oxidase 3
  • Peroxisomal Acyl-Coenzyme A Oxidase 2 3
  • EC 1.17.99.3 4
  • BRCOX 3
  • BCOX 3

External Ids for ACOX2 Gene

Previous GeneCards Identifiers for ACOX2 Gene

  • GC03M057354
  • GC03M057859
  • GC03M058345
  • GC03M058448
  • GC03M058465

Summaries for ACOX2 Gene

Entrez Gene Summary for ACOX2 Gene

  • The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]

GeneCards Summary for ACOX2 Gene

ACOX2 (Acyl-CoA Oxidase 2, Branched Chain) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include receptor binding and acyl-CoA dehydrogenase activity. An important paralog of this gene is ACOX3.

UniProtKB/Swiss-Prot for ACOX2 Gene

  • Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOX2 Gene

Genomics for ACOX2 Gene

Regulatory Elements for ACOX2 Gene

Genomic Location for ACOX2 Gene

Start:
58,505,136 bp from pter
End:
58,537,319 bp from pter
Size:
32,184 bases
Orientation:
Minus strand

Genomic View for ACOX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOX2 Gene

Proteins for ACOX2 Gene

  • Protein details for ACOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99424-ACOX2_HUMAN
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 2
    Protein Accession:
    Q99424
    Secondary Accessions:
    • A6NF16
    • B2R8U5

    Protein attributes for ACOX2 Gene

    Size:
    681 amino acids
    Molecular mass:
    76827 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Heterodimer.

neXtProt entry for ACOX2 Gene

Proteomics data for ACOX2 Gene at MOPED

Post-translational modifications for ACOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOX2 Gene

No data available for DME Specific Peptides for ACOX2 Gene

Domains for ACOX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99424

UniProtKB/Swiss-Prot:

ACOX2_HUMAN :
  • Q99424
Family:
  • Belongs to the acyl-CoA oxidase family.
genes like me logo Genes that share domains with ACOX2: view

No data available for Gene Families for ACOX2 Gene

Function for ACOX2 Gene

Molecular function for ACOX2 Gene

GENATLAS Biochemistry: peroxisomal acyl-CoA oxidase,acting on the CoA-esters of bile acid intermediates and pristanic acid ,expressed in liver and extrahepatic tissues,about null activity in the Zellweger cerebrohepatorenal syndrome
UniProtKB/Swiss-Prot CatalyticActivity: (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor
UniProtKB/Swiss-Prot Function: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids

Enzyme Numbers (IUBMB) for ACOX2 Gene

Gene Ontology (GO) - Molecular Function for ACOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003995 acyl-CoA dehydrogenase activity IEA --
GO:0003997 acyl-CoA oxidase activity TAS --
GO:0005102 receptor binding IPI 20178365
GO:0016402 pristanoyl-CoA oxidase activity TAS --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors --
genes like me logo Genes that share ontologies with ACOX2: view

Animal Model Products

CRISPR Products

miRNA for ACOX2 Gene

miRTarBase miRNAs that target ACOX2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACOX2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACOX2 Gene

Localization for ACOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOX2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOX2 Gene COMPARTMENTS Subcellular localization image for ACOX2 gene
Compartment Confidence
peroxisome 5
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 2079609
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with ACOX2: view

Pathways for ACOX2 Gene

genes like me logo Genes that share pathways with ACOX2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ACOX2 Gene

Gene Ontology (GO) - Biological Process for ACOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process --
GO:0006635 fatty acid beta-oxidation --
GO:0006699 bile acid biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0008206 bile acid metabolic process TAS --
genes like me logo Genes that share ontologies with ACOX2: view

Compounds for ACOX2 Gene

(35) HMDB Compounds for ACOX2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(4) Novoseek inferred chemical compound relationships for ACOX2 Gene

Compound -log(P) Hits PubMed IDs
pristanic acid 93.1 1
acyl-coa 85.5 9
tripeptide 62.9 1
sterol 52.3 2
genes like me logo Genes that share compounds with ACOX2: view

Transcripts for ACOX2 Gene

Unigene Clusters for ACOX2 Gene

Acyl-CoA oxidase 2, branched chain:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACOX2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOX2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - - - -
SP2: - - - -
SP3:
SP4:
SP5: - - -
SP6: -
SP7: - -
SP8: - -
SP9: -
SP10: -
SP11: -

ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ACOX2 Gene

GeneLoc Exon Structure for
ACOX2
ECgene alternative splicing isoforms for
ACOX2

Expression for ACOX2 Gene

mRNA expression in normal human tissues for ACOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOX2 Gene

This gene is overexpressed in Liver (12.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOX2 Gene

SOURCE GeneReport for Unigene cluster for ACOX2 Gene Hs.444959

mRNA Expression by UniProt/SwissProt for ACOX2 Gene

Q99424-ACOX2_HUMAN
Tissue specificity: Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney
genes like me logo Genes that share expressions with ACOX2: view

In Situ Assay Products

Orthologs for ACOX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOX2 35
  • 99.46 (n)
  • 99.27 (a)
ACOX2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACOX2 35
  • 83.14 (n)
  • 80 (a)
ACOX2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOX2 35
  • 84.39 (n)
  • 79.15 (a)
ACOX2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acox2 35
  • 79.83 (n)
  • 73.42 (a)
Acox2 16
Acox2 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACOX2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Acox2 35
  • 79.1 (n)
  • 74.01 (a)
chicken
(Gallus gallus)
Aves ACOX2 35
  • 63.17 (n)
  • 58.51 (a)
ACOX2 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOX2 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16340 35
tropical clawed frog
(Silurana tropicalis)
Amphibia acox2 35
  • 60.18 (n)
  • 55.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acox57D-d 36
  • 34 (a)
ManyToMany
Acox57D-p 36
  • 34 (a)
ManyToMany
CG4586 36
  • 34 (a)
ManyToMany
CG5009 36
  • 36 (a)
ManyToMany
CG4586 37
  • 34 (a)
Acox57D-p 37
  • 37 (a)
Acox57D-d 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea acox-1 36
  • 37 (a)
ManyToMany
C48B4.1 36
  • 33 (a)
ManyToMany
F08A8.2 36
  • 36 (a)
ManyToMany
F08A8.3 36
  • 35 (a)
ManyToMany
F08A8.4 36
  • 37 (a)
ManyToMany
F59F4.1 36
  • 36 (a)
ManyToMany
F08A8.4 37
  • 37 (a)
F08A8.3 37
  • 36 (a)
F08A8.1 37
  • 37 (a)
C48B4.1 37
  • 33 (a)
F08A8.2 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POX1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
Species with no ortholog for ACOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACOX2 Gene

ENSEMBL:
Gene Tree for ACOX2 (if available)
TreeFam:
Gene Tree for ACOX2 (if available)

Paralogs for ACOX2 Gene

Paralogs for ACOX2 Gene

Selected SIMAP similar genes for ACOX2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ACOX2: view

Variants for ACOX2 Gene

Sequence variations from dbSNP and Humsavar for ACOX2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1127743 -- 58,526,648(-) CACGC(A/G)CTGAG reference, synonymous-codon
rs1127745 -- 58,526,510(-) TCCTG(C/T)ACCTA synonymous-codon, reference
rs4074341 -- 58,531,034(-) TGCTC(A/G)TCACA intron-variant
rs4234391 -- 58,536,675(+) CCAGC(A/T)TTTGC intron-variant, upstream-variant-2KB
rs4317122 -- 58,513,116(+) tagct(C/T)cccct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOX2 Gene

Variant ID Type Subtype PubMed ID
nsv876831 CNV Gain 21882294
nsv3839 CNV Loss 18451855
nsv520486 CNV Gain 19592680
nsv876832 CNV Loss 21882294

Relevant External Links for ACOX2 Gene

HapMap Linkage Disequilibrium report
ACOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOX2 Gene

Disorders for ACOX2 Gene

(1) University of Copenhagen DISEASES for ACOX2 Gene

Relevant External Links for ACOX2

Genetic Association Database (GAD)
ACOX2
Human Genome Epidemiology (HuGE) Navigator
ACOX2
genes like me logo Genes that share disorders with ACOX2: view

No data available for UniProtKB/Swiss-Prot for ACOX2 Gene

Publications for ACOX2 Gene

  1. Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger's syndrome. (PMID: 8943006) Baumgart E. … Van Veldhoven P.P. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver. (PMID: 2079609) Casteels M. … Mannaerts G.P. (J. Lipid Res. 1990) 3 23
  3. The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney. (PMID: 8387517) Vanhove G.F. … Mannaerts G.P. (J. Biol. Chem. 1993) 3 23
  4. Assignment of the human peroxisomal branched-chain acyl-CoA oxidase gene to chromosome 3p21.1-p14.2 by rodent/human somatic cell hybridization. (PMID: 9070889) Moghrabi N.N. … Bennett M.J. (Biochem. Biophys. Res. Commun. 1997) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ACOX2 Gene

Sources for ACOX2 Gene

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