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Aliases for ACOT9 Gene

Aliases for ACOT9 Gene

  • Acyl-CoA Thioesterase 9 2 3 4
  • Acyl-CoA Thioester Hydrolase 9 3 4
  • Acyl-Coenzyme A Thioesterase 2, Mitochondrial 3
  • Mitochondrial Acyl-CoA Thioesterase 3
  • EC 3.1.2.15 63
  • EC 3.1.2.- 4
  • MT-ACT48 3
  • EC 3.1.2 63
  • MTACT48 3
  • ACATE2 3
  • CGI-16 3

External Ids for ACOT9 Gene

Previous GeneCards Identifiers for ACOT9 Gene

  • GC0XM023480
  • GC0XM021460

Summaries for ACOT9 Gene

Entrez Gene Summary for ACOT9 Gene

  • The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for ACOT9 Gene

ACOT9 (Acyl-CoA Thioesterase 9) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include carboxylic ester hydrolase activity and acetyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot for ACOT9 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT9 Gene

Genomics for ACOT9 Gene

Regulatory Elements for ACOT9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACOT9 Gene

Chromosome:
X
Start:
23,702,253 bp from pter
End:
23,766,475 bp from pter
Size:
64,223 bases
Orientation:
Minus strand

Genomic View for ACOT9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT9 Gene

Proteins for ACOT9 Gene

  • Protein details for ACOT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y305-ACOT9_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 9, mitochondrial
    Protein Accession:
    Q9Y305
    Secondary Accessions:
    • B3KNC9
    • B7ZM94

    Protein attributes for ACOT9 Gene

    Size:
    439 amino acids
    Molecular mass:
    49902 Da
    Quaternary structure:
    • Interacts with NYAP1, NYAP2 and MYO16.

    Alternative splice isoforms for ACOT9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOT9 Gene

Proteomics data for ACOT9 Gene at MOPED

Selected DME Specific Peptides for ACOT9 Gene

Post-translational modifications for ACOT9 Gene

  • Ubiquitination at Lys 73, Lys 138, Lys 250, and Lys 272
  • Modification sites at PhosphoSitePlus

Other Protein References for ACOT9 Gene

Antibody Products

Domains & Families for ACOT9 Gene

Gene Families for ACOT9 Gene

Protein Domains for ACOT9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACOT9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y305

UniProtKB/Swiss-Prot:

ACOT9_HUMAN :
  • Contains 2 HotDog ACOT-type domains.
  • Belongs to the acyl coenzyme A hydrolase family.
Domain:
  • Contains 2 HotDog ACOT-type domains.
Family:
  • Belongs to the acyl coenzyme A hydrolase family.
genes like me logo Genes that share domains with ACOT9: view

Function for ACOT9 Gene

Molecular function for ACOT9 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs

Enzyme Numbers (IUBMB) for ACOT9 Gene

Gene Ontology (GO) - Molecular Function for ACOT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003986 acetyl-CoA hydrolase activity ISS --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT9: view

Phenotypes for ACOT9 Gene

GenomeRNAi human phenotypes for ACOT9:
genes like me logo Genes that share phenotypes with ACOT9: view

Animal Model Products

CRISPR Products

miRNA for ACOT9 Gene

miRTarBase miRNAs that target ACOT9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACOT9

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ACOT9 Gene

Localization for ACOT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT9 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT9 Gene COMPARTMENTS Subcellular localization image for ACOT9 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ACOT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ACOT9: view

Pathways & Interactions for ACOT9 Gene

genes like me logo Genes that share pathways with ACOT9: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ACOT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process ISS --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ACOT9: view

No data available for SIGNOR curated interactions for ACOT9 Gene

Drugs & Compounds for ACOT9 Gene

(3) Drugs for ACOT9 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
arachidonic acid Experimental Nutra Potentiation, Activator 27
ACTH Pharma 0

(34) Additional Compounds for ACOT9 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT9: view

Transcripts for ACOT9 Gene

Unigene Clusters for ACOT9 Gene

Acyl-CoA thioesterase 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACOT9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6:

Relevant External Links for ACOT9 Gene

GeneLoc Exon Structure for
ACOT9
ECgene alternative splicing isoforms for
ACOT9

Expression for ACOT9 Gene

mRNA expression in normal human tissues for ACOT9 Gene

Protein differential expression in normal tissues from HIPED for ACOT9 Gene

This gene is overexpressed in Heart (7.8) and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOT9 Gene



SOURCE GeneReport for Unigene cluster for ACOT9 Gene Hs.298885

genes like me logo Genes that share expression patterns with ACOT9: view

Protein tissue co-expression partners for ACOT9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACOT9 Gene

Orthologs for ACOT9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOT9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACOT9 35
  • 89.86 (n)
  • 89.93 (a)
ACOT9 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOT9 35
  • 89.52 (n)
  • 89.29 (a)
ACOT9 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acot9 35
  • 84.93 (n)
  • 83.11 (a)
Acot9 16
Acot10 36
  • 81 (a)
OneToMany
Acot9 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ACOT9 35
  • 99.39 (n)
  • 99.77 (a)
ACOT9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acot9 35
  • 84.17 (n)
  • 82.42 (a)
oppossum
(Monodelphis domestica)
Mammalia ACOT9 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACOT9 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACOT9 35
  • 73.47 (n)
  • 75.45 (a)
ACOT9 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOT9 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acot9 35
  • 67.43 (n)
  • 71.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25975 35
zebrafish
(Danio rerio)
Actinopterygii acot9.2 35
  • 66.41 (n)
  • 66.92 (a)
acot9.1 36
  • 61 (a)
OneToMany
acot9.2 36
  • 62 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003848 35
  • 48.45 (n)
  • 40.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1635 35
  • 46.99 (n)
  • 38.52 (a)
CG13771 36
  • 29 (a)
OneToMany
CG1635 36
  • 33 (a)
OneToMany
CG1638 36
  • 33 (a)
OneToMany
CG1774 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07D3.9 35
  • 46.8 (n)
  • 36.92 (a)
F57F4.1 36
  • 29 (a)
OneToMany
T07D3.3 36
  • 26 (a)
OneToMany
T07D3.9 36
  • 31 (a)
OneToMany
T22B7.7 36
  • 25 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER418C 35
  • 44.21 (n)
  • 35.08 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11385g 35
  • 45.9 (n)
  • 33.67 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30720 35
  • 48.7 (n)
  • 37.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2911 36
  • 44 (a)
OneToOne
Species with no ortholog for ACOT9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOT9 Gene

ENSEMBL:
Gene Tree for ACOT9 (if available)
TreeFam:
Gene Tree for ACOT9 (if available)

Paralogs for ACOT9 Gene

No data available for Paralogs for ACOT9 Gene

Variants for ACOT9 Gene

Sequence variations from dbSNP and Humsavar for ACOT9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs11175 -- 23,704,718(+) AACCA(A/G)TGGCA synonymous-codon, reference
rs13497 -- 23,703,955(-) GCAGC(A/C/G/T)GCATT missense, reference
rs473128 -- 23,706,546(-) AGTTT(C/T)GCTCT intron-variant
rs499130 -- 23,707,065(-) CCTGC(C/T)TCCGC intron-variant
rs503916 -- 23,707,630(-) CCTCC(C/T)GAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT9 Gene

Variant ID Type Subtype PubMed ID
nsv470346 CNV Gain 18288195

Variation tolerance for ACOT9 Gene

Residual Variation Intolerance Score: 72.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT9 Gene

HapMap Linkage Disequilibrium report
ACOT9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT9 Gene

Disorders for ACOT9 Gene

Relevant External Links for ACOT9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT9
genes like me logo Genes that share disorders with ACOT9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOT9 Gene

Publications for ACOT9 Gene

  1. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. (PMID: 10383425) Poupon V. … Benmerah A. (J. Biol. Chem. 1999) 2 23 67
  2. Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2). (PMID: 19497300) Mandel C.R. … Tong L. (Biochem. Biophys. Res. Commun. 2009) 23 67
  3. Detection of a mitochondrial kinase complex that mediates PKA-MEK-ERK-dependent phosphorylation of mitochondrial proteins involved in the regulation of steroid biosynthesis. (PMID: 19426868) Paz C. … PodestA! E.J. (Meth. Enzymol. 2009) 23 67
  4. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 67
  5. Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis. (PMID: 15794766) Maloberti P. … PodestA! E.J. (FEBS J. 2005) 23 67

Products for ACOT9 Gene

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