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ACOT9 Gene

protein-coding   GIFtS: 55
GCID: GC0XM023629

Acyl-CoA Thioesterase 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Thioesterase 91 2 3     Acyl-Coenzyme A Thioesterase 9, Mitochondrial2
Acyl-CoA Thioester Hydrolase 92 3     Mitochondrial Acyl-CoA Thioesterase2
MTACT482 5     EC 3.1.2.-3
ACATE22     EC 3.1.28
MT-ACT482     EC 3.1.2.158
Acyl-Coenzyme A Thioesterase 2, Mitochondrial2     

External Ids:    HGNC: 171521   Entrez Gene: 235972   Ensembl: ENSG000001231307   OMIM: 3008625   UniProtKB: Q9Y3053   

Export aliases for ACOT9 gene to outside databases

Previous GC identifers: GC0XM023480 GC0XM021460


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACOT9 Gene:
The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)

GeneCards Summary for ACOT9 Gene:
ACOT9 (acyl-CoA thioesterase 9) is a protein-coding gene. GO annotations related to this gene include and acetyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot: ACOT9_HUMAN, Q9Y305
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
fatty acids and CoASH. Active on long chain acyl-CoAs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT9 gene promoter:
         FOXD1   HNF-1A   POU2F1   HOXA5   POU2F1a   FOXJ2 (long isoform)   HNF-1   Cart-1   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT9 promoter sequence
   Search Chromatin IP Primers for ACOT9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.11

ACOT9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT9 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM023629:  view genomic region     (about GC identifiers)

Start:
23,720,370 bp from pter      End:
23,784,592 bp from pter
Size:
64,223 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACOT9_HUMAN, Q9Y305 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 9, mitochondrial precursor  
Size: 439 amino acids; 49902 Da
Subunit: Interacts with NYAP1, NYAP2 and MYO16 (By similarity)
Secondary accessions: B3KNC9 B7ZM94
Alternative splicing: 4 isoforms:  Q9Y305-1   Q9Y305-2   Q9Y305-3   Q9Y305-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACOT9: NX_Q9Y305

Explore proteomics data for ACOT9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys73, Lys138, Lys250, Lys272
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ACOT9 (Q9Y305)
     VRDKLREI  NYIQVRVHSEV 


    See ACOT9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001028755.2  NP_001032248.1  

    ENSEMBL proteins: 
     ENSP00000368605   ENSP00000336580   ENSP00000368597   ENSP00000420238   ENSP00000420490  
     ENSP00000417778  

    ACOT9 Human Recombinant Protein Products:

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    Novus Biologicals ACOT9 Protein
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    Cloud-Clone Corp. Proteins for ACOT9

     
    Search eBioscience for Proteins for ACOT9 

    ACOT9 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ACOT9

    ACOT9 Assay Products:

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    Cloud-Clone Corp. ELISAs for ACOT9
    Cloud-Clone Corp. CLIAs for ACOT9
    Search eBioscience for ELISAs for ACOT9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACOT: Acyl CoA thioesterases

    1 InterPro protein domain:
     IPR006683 Thioestr_supf

    Graphical View of Domain Structure for InterPro Entry Q9Y305

    ProtoNet protein and cluster: Q9Y305

    UniProtKB/Swiss-Prot: ACOT9_HUMAN, Q9Y305
    Similarity: Belongs to the acyl coenzyme A hydrolase family


    Find genes that share domains with ACOT9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACOT9_HUMAN, Q9Y305
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
    fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
    fatty acids and CoASH. Active on long chain acyl-CoAs

         Enzyme Numbers (IUBMB): EC 3.1.22 EC 3.1.2.152 EC 3.1.2.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003986acetyl-CoA hydrolase activity ISS--
         
    Find genes that share ontologies with ACOT9           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Acot9 (no phenotypes)

    Find genes that share phenotypes with ACOT9           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACOT9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACOT9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACOT9

    miRNA
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    miRTarBase miRNAs that target ACOT9:
    hsa-mir-421 (MIRT039370), hsa-mir-193b-3p (MIRT041228)

    Block miRNA regulation of human, mouse, rat ACOT9 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ACOT9
    SwitchGear 3'UTR luciferase reporter plasmidACOT9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACOT9
    Predesigned siRNA for gene silencing in human, mouse, rat ACOT9

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ACOT9 (NM_001033583)
    Sino Biological Human cDNA Clone for ACOT9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT9

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACOT9_HUMAN, Q9Y305: Mitochondrion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--

    Find genes that share ontologies with ACOT9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACOT9 About    
    See pathways by source

    SuperPathContained pathways About
    1acyl-CoA hydrolysis
    acyl-CoA hydrolysis


    1 BioSystems Pathway for ACOT9
        acyl-CoA hydrolysis



        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT9: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ACOT9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for ACOT9 (Q9Y3052, 3 ENSP000003686054) via UniProtKB, MINT, STRING, and/or I2D (see all 267)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MINOS1Q5TGZ03, ENSP000003255624I2D: score=1 STRING: ENSP00000325562
    ECI1P421262, ENSP000003017294MINT-8079030 STRING: ENSP00000301729
    ALADP137163I2D: score=5 
    RPL35AP180773I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006637acyl-CoA metabolic process ISS--

    Find genes that share ontologies with ACOT9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACOT9

    Selected HMDB Compounds for ACOT9 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    5 Novoseek inferred chemical compound relationships for ACOT9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acyl-coa 85.2 19 12530634 (2), 10383425 (2), 9445388 (1), 11446442 (1) (see all 10)
    ndga 74.3 4 12530634 (1), 12423359 (1)
    arachidonic acid 60.8 7 15666797 (1), 12530634 (1), 15794766 (1), 19426868 (1) (see all 5)
    steroid 53.5 1 15794766 (1)
    acth 48.9 1 12530634 (1)



    Find genes that share compounds with ACOT9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACOT9 gene (2 alternative transcripts): 
    NM_001033583.2  NM_001037171.1  

    Unigene Cluster for ACOT9:

    Acyl-CoA thioesterase 9
    Hs.298885  [show with all ESTs]
    Unigene Representative Sequence: AK024337
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379303(uc004dao.3 uc004dap.3 uc011mjt.2 uc004dar.3)
    ENST00000336430 ENST00000379297(uc004dan.3) ENST00000379295 ENST00000494361(uc004dat.1)
    ENST00000473710 ENST00000449612 ENST00000492081
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate ACOT9
    SwitchGear 3'UTR luciferase reporter plasmidACOT9 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ACOT9 (NM_001033583)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT9
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACOT9
      QuantiTect SYBR Green Assays in human, mouse, rat ACOT9
      QuantiFast Probe-based Assays in human, mouse, rat ACOT9

    Additional mRNA sequence: 

    AF132950.1 AF241787.1 AK000659.1 AK024337.1 BC012573.1 BC136671.1 BC144360.1 

    11 DOTS entries:

    DT.313092  DT.97844126  DT.91757069  DT.95266380  DT.75151338  DT.121322876  DT.121322878  DT.91653997 
    DT.97844125  DT.121322887  DT.95203040 

    Selected AceView cDNA sequences (see all 210):

    BM806753 CA446194 BI823180 BG574653 BU686882 CK724962 CB054686 BM788824 
    AI949212 BF593312 AF241787 AA535951 BF740044 AI417047 AA707027 W31701 
    AU098774 CR626755 BQ029600 AU103245 CR618320 AL567555 AA857290 AA612730 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACOT9 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                          -                                               -     -                                             
    SP2:                                                                          -     -                                             
    SP3:                    -     -                                               -     -                                             
    SP4:                                                  -                       -     -                                             
    SP5:                    -     -                                   -                                                               


    ECgene alternative splicing isoforms for ACOT9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACOT9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGGCCCAG
    ACOT9 Expression
    About this image

    ACOT9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.298885
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT9: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACOT9
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACOT9
    QuantiTect SYBR Green Assays in human, mouse, rat ACOT9
    QuantiFast Probe-based Assays in human, mouse, rat ACOT9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACOT9 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot91 , 5 acyl-CoA thioesterase 91, 5 84.93(n)1
    83.11(a)1
      X (72.38 cM)5
    563601  NM_019736.31  NP_062710.21 
     1552624435 
    chicken
    (Gallus gallus)
    Aves ACOT91 acyl-CoA thioesterase 9 73.47(n)
    75.45(a)
      418600  NM_001012823.1  NP_001012841.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACOT96
    acyl-CoA thioesterase 9
    68(a)
    1 ↔ 1
    3(125643204-125673321)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.259752 Xenopus laevis transcribed sequence with moderate similarity more 75.92(n)    CD100020.1 
    zebrafish
    (Danio rerio)
    Actinopterygii acot9.21 acyl-CoA thioesterase 9, tandem duplicate 2 66.41(n)
    66.92(a)
      798008  NM_001037399.1  NP_001032476.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16351 CG1635 46.99(n)
    38.52(a)
      43720  NM_143616.3  NP_651873.3 
    worm
    (Caenorhabditis elegans)
    Secernentea T07D3.91 T07D3.9 46.8(n)
    36.92(a)
      173471  NM_061442.4  NP_493843.2 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AER418C1 AGOS_AER418C 44.21(n)
    35.08(a)
      4621492  NM_210627.1  NP_985273.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G307201 AT2G30720 48.7(n)
    37.01(a)
      817623  NM_128625.3  NP_180630.2 


    ENSEMBL Gene Tree for ACOT9 (if available)
    TreeFam Gene Tree for ACOT9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACOT9 (see all 759)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0626684
    A pancreatic ductal adenocarcinoma sample4--see VAR_0626682 N H mis40--------
    rs1852902201,2
    --23635991(+) CTTGAA/TCTCCT 2 -- ds50010--------
    rs1899809831,2
    --23636126(+) TAAAAC/TTGTCT 2 -- ut310--------
    rs2000420971,2
    C--23636377(+) AGGTCA/GCTGGG 4 A V mis10--------
    rs2011058081,2
    --23636386(+) GGCCAC/TTCATG 4 N S mis10--------
    rs134971,2
    C--23636404(-) GCAGCG/TGCATT 4 R L mis12Minor allele frequency- T:0.00NA 4
    rs1500259991,2
    --23636498(+) TCATAC/TAAACA 2 -- int10--------
    rs1825751791,2
    --23636672(+) TGGAGA/TGCAGT 2 -- int10--------
    rs125572271,2
    C,H--23636705(+) AGCTCT/CGCCTC 2 -- int11Minor allele frequency- C:0.00NA 2
    rs2004865581,2
    C--23636830(+) TTCACC/TGTGTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ACOT9 (23720370 - 23784592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ACOT9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470346CNV Gain18288195

    Locus Specific Mutation Databases (LSDB): ACOT9

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACOT9
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300862    OMIM disorders: --


    Find genes that share disorders with ACOT9           About GenesLikeMe


    Export disorders for ACOT9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACOT9 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with ACOT9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    2. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. (PubMed id 10383425)1, 3, 9 Poupon V....Benmerah A. (J. Biol. Chem. 1999)
    3. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (J. Lipid Res. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    6. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. (PubMed id 22114354)1 Alkhaja A.K.... Deckers M. (Mol. Biol. Cell 2012)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    8. FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. (PubMed id 22323290)1 Mulkearns E.E. and Cooper J.A. (Mol. Biol. Cell 2012)
    9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23597 HGNC: 17152 AceView: ACATE2 Ensembl:ENSG00000123130 euGenes: HUgn23597
    ECgene: ACOT9 H-InvDB: ACOT9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACOT9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACOT9 gene:
    Search GeneIP for patents involving ACOT9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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