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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACOT8 Gene

protein-coding GIFtS: 57
GCID: GC20M044470

acyl-CoA thioesterase 8

(Previous names: peroxisomal acyl-CoA thioesterase, peroxisomal acyl-CoA...)
(Previous symbol: PTE1)

Explore 7 diseases affiliated with
ACOT8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acyl-CoA Thioesterase 8¹ ² ³		Peroxisomal Acyl-CoA Thioesterase¹
PTE1¹ ² ³ ⁵		HNAACTE²
PTE-2¹ ² ³		Acyl-Coenzyme A Thioesterase 8²
HACTE-III¹		Choloyl-CoA Hydrolase²
HTE¹		HIV-Nef Associated Acyl-CoA Thioesterase²
Peroxisomal Acyl-CoA Thioesterase 1¹ ²		Long-Chain Fatty-Acyl-CoA Hydrolase²
Choloyl-Coenzyme A Thioesterase² ³		Palmitoyl-CoA Hydrolase²
Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1² ³		Thioesterase III²
Peroxisomal Long-Chain Acyl-CoA Thioesterase 1² ³		ACTEIII³
Thioesterase II² ³		EC 3.1.2.27³
PTE-1² ³		HACTEIII¹
PTE2² ³		HIV-Nef-Associated Acyl-CoA Thioesterase³

External Ids:	HGNC: 15919¹	Entrez Gene: 10005²	Ensembl: ENSG00000101473⁷	OMIM: 608123⁵	UniProtKB: O14734³

Export aliases for ACOT8 gene to outside databases

Previous GC identifers: GC20M043904 GC20M041212

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACOT8:

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of

fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein

Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734

Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty

acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids

and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile

acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a

preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of

peroxisome proliferation

Gene Wiki entry for ACOT8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACOT8 gene promoter:
PPAR-alpha USF-1 MyoD MIF-1 Tal-1beta c-Ets-1 Gfi-1 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACOT8 promoter sequence

Search SABiosciences Chromatin IP Primers for ACOT8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACOT8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12

ACOT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT8 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M044470: view genomic region (about GC identifiers)

Start:	44,470,360 bp from pter	End:	44,486,045 bp from pter
Size:	15,686 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734 (See protein sequence)

Recommended Name: Acyl-coenzyme A thioesterase 8

Size: 319 amino acids; 35914 Da

Subunit: Interacts with HIV-1 Nef

Subcellular location: Peroxisome

Secondary accessions: O15261 Q17RX4

Explore the universe of human proteins at neXtProt for ACOT8: NX_O14734

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14734

ACOT8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005460.2

ENSEMBL proteins:

ENSP00000217455 ENSP00000435581 ENSP00000435115 ENSP00000419403 ENSP00000434216

ENSP00000433923 ENSP00000431175 ENSP00000403862 ENSP00000416217

Reactome Protein details: O14734
Human Recombinant Protein Products:

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	Uscn Proteins for ACOT8

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005777	peroxisome	--	--
GO:0005782	peroxisomal matrix	TAS	--

ACOT8 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACOT8 for domains About GeneDecksing

1 InterPro domain/family:

IPR003703 Acyl_CoA_thio

Graphical View of Domain Structure for InterPro Entry O14734

ProtoNet protein and cluster: O14734

1 Blocks protein family: IPB003703 Acyl-CoA thioesterase

UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734

Similarity: Belongs to the C/M/P thioester hydrolase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734

Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty

acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids

and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile

acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a

preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of

peroxisome proliferation

Catalytic activity: Choloyl-CoA + H(2)O = cholate + CoA

Induction: Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated

receptors (PPARs) (By similarity)

Enzyme Number (IUBMB): EC 3.1.2.27¹

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In Situ Assay
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ACOT8

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004091	carboxylesterase activity	IEA	--
GO:0005102	receptor binding	IPI	--
GO:0005515	protein binding	IPI	--
GO:0016290	palmitoyl-CoA hydrolase activity	IDA	9299485
GO:0033882	choloyl-CoA hydrolase activity	IEA	--

ACOT8 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ACOT8:

Decreased Hepatitis C virus re

Animal Models:
1 MGI phenotypic allele

for Acot8 (no phenotypes)

ACOT8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	1.00			Beta-oxidation of very long chain fatty acids	0.42
	alpha-linolenic acid (ALA) metabolism	1.00

Synthesis of bile acids and bile salts

	Synthesis of bile acids and bile salts	1.00			Bile acid and bile salt metabolism	0.70
	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.79

Peroxisomal lipid metabolism

Peroxisomal lipid metabolism

1.00

Beta-oxidation of pristanoyl-CoA

0.40

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

acyl-CoA hydrolysis

acyl-CoA hydrolysis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for ACOT8

acyl-CoA hydrolysis

5/10 Reactome Pathways for ACOT8 (see all 10)

	Beta-oxidation of pristanoyl-CoA
	Beta-oxidation of very long chain fatty acids
	Bile acid and bile salt metabolism
	Metabolism
	Peroxisomal lipid metabolism

1 Kegg Pathway (Kegg details for ACOT8):

Peroxisome

ACOT8 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ACOT8

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/17 Interacting proteins for ACOT8 (O14734^{1, 3} ENSP00000217455⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYC	P01106³, ENSP00000367207⁴	I2D: score=3 STRING: ENSP00000367207
EIF2B1	Q14232³	I2D: score=5
MARCH6	O60337³	I2D: score=3
PRPF40A	O75400³	I2D: score=3
ATG2A	Q2TAZ0³	I2D: score=1

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006637	acyl-CoA metabolic process	IDA	9299485
GO:0006699	bile acid biosynthetic process	TAS	--
GO:0007031	peroxisome organization	--	--
GO:0008206	bile acid metabolic process	TAS	--
GO:0016559	peroxisome fission	IDA	15194431

ACOT8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ACOT8 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACOT8

10/51 HMDB Compounds for ACOT8 (see all 51) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
8,11,14-Eicosatrienoic acid	(8Z,11Z,14Z)-Icosatrienoate (see all 34)	1783-84-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--

3 Novoseek chemical compound relationships for ACOT8 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acyl-coa	80.8	12	10944470 (5), 9299485 (1), 16141203 (1), 16061252 (1)
tripeptide	56.8	1	10944470 (1)
fatty acid	39.2	1	9299485 (1)

Search CenterWatch for drugs/clinical trials and news about ACOT8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACOT8 gene (3 alternative transcripts):

NM_005469.3 NM_183385.1 NM_183386.1

Unigene Cluster for ACOT8:

Acyl-CoA thioesterase 8

Hs.444776 [show with all ESTs]

Unigene Representative Sequence: AK126206

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000217455(uc002xqa.2) ENST00000461272 ENST00000488679 ENST00000487205

ENST00000484975 ENST00000493118(uc010zxe.2 uc002xqc.2 uc010zxf.2)

ENST00000483141 ENST00000484783 ENST00000486165 ENST00000481938 ENST00000457981

ENST00000426915

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Additional cDNA sequence:

AF014404.1 AF124264.1 AK126206.1 AK292494.1 AK296973.1 AK298783.1 BC117155.1 BC117157.1

CR541771.1 CR541778.1 X86032.1

19 DOTS entries:

DT.95336060 DT.447426 DT.97775420 DT.100812148 DT.100812145 DT.97852110 DT.120817181 DT.40221673

DT.95336063 DT.120817131 DT.120817654 DT.95078177 DT.120817515 DT.75100429 DT.100812152 DT.120817697

DT.120817794 DT.120817875 DT.97852086

24/175 AceView cDNA sequences (see all 175):

AI336343 BM917608 CB123555 CD674471 BM558216 BM669590 NM_005469 CB155430

BM809821 CB128647 BM916884 BU528923 AI371051 BM980988 BM978027 BQ934130

CF529393 BM723645 BM986979 BE246518 BQ019230 NM_183386 CA425098 BM927419

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACOT8 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:													-		-														-		-
SP2:													-		-														-		-
SP3:											-		-		-
SP4:													-		-
SP5:													-

ECgene alternative splicing isoforms for ACOT8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACOT8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCGGCTGTG

About this image
See ACOT8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACOT8

SOURCE GeneReport for Unigene cluster: Hs.444776

UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734

Tissue specificity: Detected in a T-cell line (at protein level). Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including ACOT8:

Fatty Acid Metabolism in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ACOT8 gene from 9/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Acot8^{1 , 5}	acyl-CoA thioesterase 8^{1, 5}	84.85(n)¹ 84.95(a)¹		2 (85.27 cM)⁵ 170789¹ NM_133240.2¹ NP_573503.2¹ 164792768⁵
chicken (Gallus gallus)	Aves	ACOT8¹	acyl-CoA thioesterase 8	72.33(n) 74.84(a)		419303 XM_417475.3 XP_417475.2
lizard (Anolis carolinensis)	Reptilia	ACOT8⁶	--	68(a)	1 ↔ 1	GL344721.1(1-12550)
African clawed frog (Xenopus laevis)	Amphibia	Xl.13325²	Xenopus laevis transcribed sequence with weak similarity more	77.98(n)		BJ082654.1
zebrafish (Danio rerio)	Actinopterygii	acot8¹	acyl-CoA thioesterase 8	67.57(n) 71.62(a)		450052 NM_001006072.1 NP_001006072.1
worm (Caenorhabditis elegans)	Secernentea	F25E2.3¹	Protein F25E2.3	48.05(n) 43.14(a)		180429 NM_075758.4 NP_508159.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G01710⁶ AT4G00520⁶	acyl-CoA thioesterase family protein	29(a) 28(a)	many → 1 many → 1	1(262828-267771) 4(227694-231699)
rice (Oryza sativa)	Liliopsida	Os04g0558400¹	hypothetical protein	49.69(n) 45.76(a)		4336637 NM_001060068.1 NP_001053533.1
E. coli (Escherichia coli)	Gamma proteobacteria	tesB⁶	acyl-CoA thioesterase II	40(a)	1 ↔ 1	Chromosome(473525-474385)

ENSEMBL Gene Tree for ACOT8 (if available)
TreeFam Gene Tree for ACOT8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190188488^1,2		--	44470093(+)	`AGCAGA/CTCAAG`	5	--	ut3¹ ds500¹ int¹		0	--	--	--	--
rs6017702^1,2	C,H	--	44470167(+)	`GAAGTC/TTGACA`	5	--	ut3¹ int¹ ds500¹		4		NS EA	398
rs12106124^1,2	C,F,	--	44470198(+)	`CAGCCG/AGGGGG`	5	--	ut3¹ ds500¹ int¹		1		WA	118
rs145182943^1,2	C,	--	44470438(+)	`AGATGA/GGAGGT`	5	--	ut3¹ int¹		0	--	--	--	--
rs73308468^1,2	C,	--	44470468(+)	`GCTGGC/TACCTC`	5	--	ut3¹ int¹		1		WA	2
rs1048913^1,2	C,H	--	44470495(-)	`CAGGTC/TTCAGA`	6	V	ut3¹ int¹ syn¹ ese³		6		MN NS EA NA	606
rs147976812^1,2	C,F,	--	44470513(+)	`ACTCGG/CATCAC`	6	/I /M	ut3¹ mis¹ int¹		1		NA	4310
rs141643903^1,2	C,F	--	44470518(+)	`GATCAC/TGCCCT`	6	M V	ut3¹ mis¹ int¹		2		NA EU	5027
rs138553906^1,2	C	--	44470571(+)	`GCCGCC/TCATGG`	6	E G	ut3¹ mis¹ int¹		1		NA	4458
rs148674138^1,2	C,F,	--	44470575(+)	`CCCATG/AGACCA`	6	/H /Y	ut3¹ int¹ mis¹		2		NA EU	5509

HapMap Linkage Disequilibrium report for ACOT8 (44470360 - 44486045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ACOT8
1 CNV: 50668

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ACOT8 for disorders           About GeneDecksing

OMIM gene information: 608123    OMIM disorders: --

7 diseases for ACOT8:    About MalaCards

von economo's disease immunodeficiency hypertensive encephalopathy hypertension

tuberculosis neuronitis mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for ACOT8:

Plague

1 Novoseek disease relationship for ACOT8 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	10.9	2	10799608 (1), 10092594 (1)

Export disorders for ACOT8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ACOT8 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with ACOT8)

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Identification of peroxisomal acyl-CoA thioesterases in yeast and humans. (PubMed id 10092594)^{1, 2, 3, 9} Jones J.M.... Gould S.J. (1999)
Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. (PubMed id 9153233)^{1, 2, 3} Liu L.X.... Benichou S. (1997)
A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef. (PubMed id 9299485)^{1, 2, 9} Watanabe H.... Saito T. (1997)
Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PubMed id 16940157)^{1, 3} Hunt M.C....Alexson S.E. (2006)
A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)^{1, 3} Hunt M.C....Alexson S.E. (2005)
Overexpression of human acyl-CoA thioesterase upregulates peroxisome biogenesis. (PubMed id 15194431)^{1, 2} Ishizuka M.... Saito T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism. (PubMed id 11755680)^{1, 2} Hunt M.C. and Alexson S.E.H. (2002)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PubMed id 10944470)^{1, 9} Jones J.M. and Gould S.J. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10005	HGNC: 15919	AceView: PTE1	Ensembl:ENSG00000101473	euGenes: HUgn10005
ECgene: ACOT8	Kegg: 10005	H-InvDB: ACOT8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ACOT8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACOT8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACOT8 gene:
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GeneCards and IP:
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ACOT8 Gene

acyl-CoA thioesterase 8

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ACOT8 (Gene Symbol)
Acyl-CoA Thioesterase 8
PTE1
PTE-2
HACTE-III
HTE
Peroxisomal Acyl-CoA Thioesterase 1
Choloyl-Coenzyme A Thioesterase
Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1
Peroxisomal Long-Chain Acyl-CoA Thioesterase 1
Thioesterase II
PTE-1
PTE2
Peroxisomal Acyl-CoA Thioesterase
HNAACTE
Acyl-Coenzyme A Thioesterase 8
Choloyl-CoA Hydrolase
HIV-Nef Associated Acyl-CoA Thioesterase
Long-Chain Fatty-Acyl-CoA Hydrolase
Palmitoyl-CoA Hydrolase
Thioesterase III
ACTEIII
EC 3.1.2.27
HACTEIII
HIV-Nef-Associated Acyl-CoA Thioesterase

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ACOT8 Gene

acyl-CoA thioesterase 8

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