Aliases for ACOT8 Gene
- Acyl-CoA Thioesterase 8 2 3 4 5
- Nef (Lentivirus Myristoylated Factor) Associated Protein 1 2 3
- Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1 3 4
- Peroxisomal Long-Chain Acyl-CoA Thioesterase 1 3 4
- Peroxisomal Acyl-CoA Thioesterase 1 2 3
- Choloyl-Coenzyme A Thioesterase 3 4
- Choloyl-CoA Hydrolase 2 3
- Thioesterase II 3 4
- HACTE-III 3 4
- PTE-1 3 4
- PTE-2 3 4
- PTE2 3 4
- PTE1 3 4
- HTE 3 4
External Ids for ACOT8 Gene
Previous HGNC Symbols for ACOT8 Gene
Previous GeneCards Identifiers for ACOT8 Gene
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]
GeneCards Summary for ACOT8 Gene
ACOT8 (Acyl-CoA Thioesterase 8) is a Protein Coding gene. Diseases associated with ACOT8 include Von Economo's Disease. Among its related pathways are Metabolism and Synthesis of bile acids and bile salts. GO annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity.
UniProtKB/Swiss-Prot for ACOT8 Gene
Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).
(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).