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Aliases for ACOT8 Gene

Aliases for ACOT8 Gene

  • Acyl-CoA Thioesterase 8 2 3 4
  • PTE1 3 4 6
  • Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1 3 4
  • Peroxisomal Long-Chain Acyl-CoA Thioesterase 1 3 4
  • Peroxisomal Acyl-CoA Thioesterase 1 2 3
  • Choloyl-Coenzyme A Thioesterase 3 4
  • Choloyl-CoA Hydrolase 2 3
  • Thioesterase II 3 4
  • HACTE-III 3 4
  • PTE-1 3 4
  • PTE-2 3 4
  • PTE2 3 4
  • HTE 3 4
  • HIV-Nef Associated Acyl-CoA Thioesterase 3
  • HIV-Nef-Associated Acyl-CoA Thioesterase 4
  • Long-Chain Fatty-Acyl-CoA Hydrolase 3
  • Peroxisomal Acyl-CoA Thioesterase 2
  • Acyl-Coenzyme A Thioesterase 8 3
  • Palmitoyl-CoA Hydrolase 3
  • Thioesterase III 3
  • EC 3.1.2.27 4
  • HACTEIII 4
  • HNAACTE 3
  • ACTEIII 4

External Ids for ACOT8 Gene

Previous Symbols for ACOT8 Gene

  • PTE1

Summaries for ACOT8 Gene

Entrez Gene Summary for ACOT8 Gene

  • The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

GeneCards Summary for ACOT8 Gene

ACOT8 (Acyl-CoA Thioesterase 8) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot for ACOT8 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.

Gene Wiki entry for ACOT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT8 Gene

Genomics for ACOT8 Gene

Genomic Location for ACOT8 Gene

Start:
45,841,721 bp from pter
End:
45,857,409 bp from pter
Size:
15,689 bases
Orientation:
Minus strand

Genomic View for ACOT8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT8 Gene

Regulatory Elements for ACOT8 Gene

Proteins for ACOT8 Gene

  • Protein details for ACOT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14734-ACOT8_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 8
    Protein Accession:
    O14734
    Secondary Accessions:
    • O15261
    • Q17RX4

    Protein attributes for ACOT8 Gene

    Size:
    319 amino acids
    Molecular mass:
    35914 Da
    Quaternary structure:
    • Interacts with HIV-1 Nef.

neXtProt entry for ACOT8 Gene

Proteomics data for ACOT8 Gene at MOPED

Post-translational modifications for ACOT8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT8 Gene

No data available for DME Specific Peptides for ACOT8 Gene

Domains for ACOT8 Gene

Gene Families for ACOT8 Gene

HGNC:
  • ACOT :Acyl CoA thioesterases

Protein Domains for ACOT8 Gene

UniProtKB/Swiss-Prot:

ACOT8_HUMAN
Family:
  • Belongs to the C/M/P thioester hydrolase family.:
    • O14734
genes like me logo Genes that share domains with ACOT8: view

Function for ACOT8 Gene

Molecular function for ACOT8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Choloyl-CoA + H(2)O = cholate + CoA
UniProtKB/Swiss-Prot Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.
UniProtKB/Swiss-Prot Induction: Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs).

Enzyme Numbers (IUBMB) for ACOT8 Gene

Gene Ontology (GO) - Molecular Function for ACOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 22190034
GO:0016290 palmitoyl-CoA hydrolase activity IDA 9299485
GO:0033882 choloyl-CoA hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity IDA 10092594
genes like me logo Genes that share ontologies with ACOT8: view

Phenotypes for ACOT8 Gene

GenomeRNAi human phenotypes for ACOT8:
genes like me logo Genes that share phenotypes with ACOT8: view

miRNA for ACOT8 Gene

miRTarBase miRNAs that target ACOT8

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACOT8 Gene

Localization for ACOT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT8 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT8 Gene COMPARTMENTS Subcellular localization image for ACOT8 gene
Compartment Confidence
peroxisome 5
cytosol 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ACOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome --
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with ACOT8: view

Pathways for ACOT8 Gene

genes like me logo Genes that share pathways with ACOT8: view

Gene Ontology (GO) - Biological Process for ACOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process IDA 9299485
GO:0006699 bile acid biosynthetic process TAS --
GO:0008206 bile acid metabolic process TAS --
GO:0016032 viral process IEA --
GO:0016559 peroxisome fission IDA 15194431
genes like me logo Genes that share ontologies with ACOT8: view

Compounds for ACOT8 Gene

(51) HMDB Compounds for ACOT8 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(3) Novoseek inferred chemical compound relationships for ACOT8 Gene

Compound -log(P) Hits PubMed IDs
acyl-coa 80.8 8
tripeptide 56.8 1
fatty acid 39.2 1
genes like me logo Genes that share compounds with ACOT8: view

Transcripts for ACOT8 Gene

Unigene Clusters for ACOT8 Gene

Acyl-CoA thioesterase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9:

Relevant External Links for ACOT8 Gene

GeneLoc Exon Structure for
ACOT8
ECgene alternative splicing isoforms for
ACOT8

Expression for ACOT8 Gene

mRNA expression in normal human tissues for ACOT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOT8 Gene

SOURCE GeneReport for Unigene cluster for ACOT8 Gene Hs.444776

mRNA Expression by UniProt/SwissProt for ACOT8 Gene

O14734-ACOT8_HUMAN
Tissue specificity: Detected in a T-cell line (at protein level). Ubiquitous.
genes like me logo Genes that share expressions with ACOT8: view

Orthologs for ACOT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT8 36
  • 99.79 (n)
  • 99.69 (a)
ACOT8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACOT8 36
  • 87.45 (n)
  • 86.08 (a)
ACOT8 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOT8 36
  • 88.5 (n)
  • 88.92 (a)
ACOT8 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acot8 36
  • 84.85 (n)
  • 84.95 (a)
Acot8 16
Acot8 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACOT8 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acot8 36
  • 85.68 (n)
  • 85.58 (a)
chicken
(Gallus gallus)
Aves ACOT8 36
  • 72.33 (n)
  • 74.84 (a)
ACOT8 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOT8 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13325 36
tropical clawed frog
(Silurana tropicalis)
Amphibia acot8 36
  • 69.45 (n)
  • 75.25 (a)
Str.3646 36
zebrafish
(Danio rerio)
Actinopterygii acot8 36
  • 67.57 (n)
  • 71.62 (a)
acot8 37
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C17C3.1 37
  • 29 (a)
OneToMany
C17C3.3 37
  • 29 (a)
OneToMany
C37H5.13 37
  • 29 (a)
OneToMany
F25E2.3 36
  • 48.07 (n)
  • 43.23 (a)
F25E2.3 37
  • 38 (a)
OneToMany
Y87G2A.2 37
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TES1 37
  • 24 (a)
OneToOne
TES1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01710 36
  • 50.66 (n)
  • 43.32 (a)
Species with no ortholog for ACOT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOT8 Gene

ENSEMBL:
Gene Tree for ACOT8 (if available)
TreeFam:
Gene Tree for ACOT8 (if available)

Paralogs for ACOT8 Gene

Selected SIMAP similar genes for ACOT8 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ACOT8: view

No data available for Paralogs for ACOT8 Gene

Variants for ACOT8 Gene

Sequence variations from dbSNP and Humsavar for ACOT8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs169103 -- 45,846,724(-) ATTCT(A/G)TCCAG intron-variant
rs174745 -- 45,846,774(-) GCTGG(C/T)ACAGG intron-variant
rs183195 -- 45,851,237(+) GAGTG(C/G)GAGCT intron-variant
rs197662 -- 45,846,967(-) gtctc(C/T)caaag intron-variant
rs197663 -- 45,846,334(-) AACTA(A/G)CACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT8 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
nsv458993 CNV Loss 19166990
nsv517296 CNV Loss 19592680

Relevant External Links for ACOT8 Gene

HapMap Linkage Disequilibrium report
ACOT8

Disorders for ACOT8 Gene

(1) University of Copenhagen DISEASES for ACOT8 Gene

(1) Novoseek inferred disease relationships for ACOT8 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 10.9 2
genes like me logo Genes that share disorders with ACOT8: view

No data available for UniProtKB/Swiss-Prot for ACOT8 Gene

Publications for ACOT8 Gene

  1. Identification of peroxisomal acyl-CoA thioesterases in yeast and humans. (PMID: 10092594) Jones J.M. … Gould S.J. (J. Biol. Chem. 1999) 2 3 4 23
  2. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. (PMID: 9153233) Liu L.X. … Benichou S. (J. Biol. Chem. 1997) 2 3 4
  3. A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef. (PMID: 9299485) Watanabe H. … Saito T. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  4. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions. (PMID: 10799608) Liu L.X. … Benarous R. (J. Virol. 2000) 3 23
  5. The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation. (PMID: 10807905) Cohen G.B. … Baltimore D. (J. Biol. Chem. 2000) 3 23

Products for ACOT8 Gene

Sources for ACOT8 Gene

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