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Aliases for ACOT8 Gene

Aliases for ACOT8 Gene

  • Acyl-CoA Thioesterase 8 2 3 4 5
  • Nef (Lentivirus Myristoylated Factor) Associated Protein 1 2 3
  • Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1 3 4
  • Peroxisomal Long-Chain Acyl-CoA Thioesterase 1 3 4
  • Peroxisomal Acyl-CoA Thioesterase 1 2 3
  • Choloyl-Coenzyme A Thioesterase 3 4
  • Choloyl-CoA Hydrolase 2 3
  • Thioesterase II 3 4
  • HACTE-III 3 4
  • PTE-1 3 4
  • PTE-2 3 4
  • PTE2 3 4
  • PTE1 3 4
  • HTE 3 4
  • HIV-Nef Associated Acyl-CoA Thioesterase 3
  • HIV-Nef-Associated Acyl-CoA Thioesterase 4
  • Long-Chain Fatty-Acyl-CoA Hydrolase 3
  • Peroxisomal Acyl-CoA Thioesterase 2
  • Palmitoyl-CoA Hydrolase 3
  • Thioesterase III 3
  • EC 3.1.2.27 4
  • HACTEIII 4
  • HNAACTE 3
  • ACTEIII 4
  • NAP1 3

External Ids for ACOT8 Gene

Previous HGNC Symbols for ACOT8 Gene

  • PTE1

Previous GeneCards Identifiers for ACOT8 Gene

  • GC20M043904
  • GC20M044470
  • GC20M041212

Summaries for ACOT8 Gene

Entrez Gene Summary for ACOT8 Gene

  • The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

GeneCards Summary for ACOT8 Gene

ACOT8 (Acyl-CoA Thioesterase 8) is a Protein Coding gene. Diseases associated with ACOT8 include Von Economo's Disease. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Peroxisomal lipid metabolism. GO annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot for ACOT8 Gene

  • Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).

  • (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).

Gene Wiki entry for ACOT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT8 Gene

Genomics for ACOT8 Gene

Regulatory Elements for ACOT8 Gene

Enhancers for ACOT8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACOT8 on UCSC Golden Path with GeneCards custom track

Promoters for ACOT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACOT8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOT8 Gene

Chromosome:
20
Start:
45,841,721 bp from pter
End:
45,857,409 bp from pter
Size:
15,689 bases
Orientation:
Minus strand

Genomic View for ACOT8 Gene

Genes around ACOT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT8 Gene

Proteins for ACOT8 Gene

  • Protein details for ACOT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14734-ACOT8_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 8
    Protein Accession:
    O14734
    Secondary Accessions:
    • O15261
    • Q17RX4

    Protein attributes for ACOT8 Gene

    Size:
    319 amino acids
    Molecular mass:
    35914 Da
    Quaternary structure:
    • Homodimer (By similarity).
    • (Microbial infection) Interacts with human immunodeficiency virus (HIV-1) Nef (via middle region); this interaction enhances ACOT8 Acyl-CoA thioesterase activity and occurs in a Nef myristoylation-independent manner (PubMed:9299485). According to a second report, the interaction with HIV-1 Nef occurs in a Nef myristoylation-independent manner but does not enhance ACOT8 Acyl-CoA thioesterase activity (PubMed:9153233).

neXtProt entry for ACOT8 Gene

Proteomics data for ACOT8 Gene at MOPED

Post-translational modifications for ACOT8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACOT8 Gene

Domains & Families for ACOT8 Gene

Gene Families for ACOT8 Gene

Protein Domains for ACOT8 Gene

Suggested Antigen Peptide Sequences for ACOT8 Gene

Graphical View of Domain Structure for InterPro Entry

O14734

UniProtKB/Swiss-Prot:

ACOT8_HUMAN :
  • Belongs to the C/M/P thioester hydrolase family.
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT8: view

Function for ACOT8 Gene

Molecular function for ACOT8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.1 uM for decanoyl-CoA {ECO:0000269 PubMed:9153233}; Vmax=7.1 umol/min/mg enzyme {ECO:0000269 PubMed:9153233};
UniProtKB/Swiss-Prot CatalyticActivity:
Choloyl-CoA + H(2)O = cholate + CoA.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by CoASH (IC(50)=10-15 uM). Also inhibited by cysteine-reactive agents.
UniProtKB/Swiss-Prot Function:
Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).
UniProtKB/Swiss-Prot Function:
(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).
UniProtKB/Swiss-Prot Induction:
Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs).

Enzyme Numbers (IUBMB) for ACOT8 Gene

Gene Ontology (GO) - Molecular Function for ACOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9153233
GO:0016289 CoA hydrolase activity TAS --
GO:0016290 palmitoyl-CoA hydrolase activity IDA 9299485
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT8: view
genes like me logo Genes that share phenotypes with ACOT8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACOT8

miRNA for ACOT8 Gene

miRTarBase miRNAs that target ACOT8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOT8 Gene

Localization for ACOT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT8 Gene

Cytoplasm. Peroxisome matrix. Note=Predominantly localized in the peroxisome (PubMed:10092594, PubMed:15194431). {ECO:0000269 PubMed:10092594, ECO:0000269 PubMed:15194431}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT8 Gene COMPARTMENTS Subcellular localization image for ACOT8 gene
Compartment Confidence
peroxisome 5
mitochondrion 4
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ACOT8 Gene

Pathways & Interactions for ACOT8 Gene

genes like me logo Genes that share pathways with ACOT8: view

Gene Ontology (GO) - Biological Process for ACOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process IEA,IDA 9153233
GO:0008206 bile acid metabolic process TAS --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0033559 unsaturated fatty acid metabolic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with ACOT8: view

No data available for SIGNOR curated interactions for ACOT8 Gene

Drugs & Compounds for ACOT8 Gene

(12) Drugs for ACOT8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chenodeoxycholic acid Approved Pharma Antagonist 27
cholic acid Approved Pharma Full agonist, Agonist 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Gamma-Homolinolenic acid Approved Nutra 0
Icosapent Approved Nutra 0

(45) Additional Compounds for ACOT8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT8: view

Transcripts for ACOT8 Gene

Unigene Clusters for ACOT8 Gene

Acyl-CoA thioesterase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9:

Relevant External Links for ACOT8 Gene

GeneLoc Exon Structure for
ACOT8
ECgene alternative splicing isoforms for
ACOT8

Expression for ACOT8 Gene

mRNA expression in normal human tissues for ACOT8 Gene

Protein differential expression in normal tissues from HIPED for ACOT8 Gene

This gene is overexpressed in Bone (31.0) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOT8 Gene



SOURCE GeneReport for Unigene cluster for ACOT8 Gene Hs.444776

mRNA Expression by UniProt/SwissProt for ACOT8 Gene

O14734-ACOT8_HUMAN
Tissue specificity: Detected in a T-cell line (at protein level). Ubiquitous (PubMed:9153233, PubMed:9299485).
genes like me logo Genes that share expression patterns with ACOT8: view

Protein tissue co-expression partners for ACOT8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ACOT8 Gene

Orthologs for ACOT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOT8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACOT8 35
  • 87.45 (n)
  • 86.08 (a)
ACOT8 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOT8 35
  • 88.5 (n)
  • 88.92 (a)
ACOT8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acot8 35
  • 84.85 (n)
  • 84.95 (a)
Acot8 16
Acot8 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACOT8 35
  • 99.79 (n)
  • 99.69 (a)
ACOT8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acot8 35
  • 85.68 (n)
  • 85.58 (a)
oppossum
(Monodelphis domestica)
Mammalia ACOT8 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACOT8 35
  • 72.33 (n)
  • 74.84 (a)
ACOT8 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOT8 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acot8 35
  • 69.45 (n)
  • 75.25 (a)
Str.3646 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13325 35
zebrafish
(Danio rerio)
Actinopterygii acot8 35
  • 67.57 (n)
  • 71.62 (a)
acot8 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F25E2.3 35
  • 48.07 (n)
  • 43.23 (a)
C17C3.1 36
  • 29 (a)
OneToMany
C17C3.3 36
  • 29 (a)
OneToMany
C37H5.13 36
  • 29 (a)
OneToMany
F25E2.3 36
  • 38 (a)
OneToMany
Y87G2A.2 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TES1 36
  • 24 (a)
OneToOne
TES1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01710 35
  • 50.66 (n)
  • 43.32 (a)
Species with no ortholog for ACOT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOT8 Gene

ENSEMBL:
Gene Tree for ACOT8 (if available)
TreeFam:
Gene Tree for ACOT8 (if available)

Paralogs for ACOT8 Gene

(1) SIMAP similar genes for ACOT8 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ACOT8: view

No data available for Paralogs for ACOT8 Gene

Variants for ACOT8 Gene

Sequence variations from dbSNP and Humsavar for ACOT8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs169103 -- 45,846,724(-) ATTCT(A/G)TCCAG intron-variant
rs174745 -- 45,846,774(-) GCTGG(C/T)ACAGG intron-variant
rs183195 -- 45,851,237(+) GAGTG(C/G)GAGCT intron-variant
rs197662 -- 45,846,967(-) gtctc(C/T)caaag intron-variant
rs197663 -- 45,846,334(-) AACTA(A/G)CACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT8 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
nsv458993 CNV Loss 19166990
nsv517296 CNV Loss 19592680

Variation tolerance for ACOT8 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACOT8 Gene

Disorders for ACOT8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACOT8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
von economo's disease
  • encephalitis lethargica
- elite association - COSMIC cancer census association via MalaCards
Search ACOT8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACOT8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT8
genes like me logo Genes that share disorders with ACOT8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT8 Gene

Publications for ACOT8 Gene

  1. Identification of peroxisomal acyl-CoA thioesterases in yeast and humans. (PMID: 10092594) Jones J.M. … Gould S.J. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3
  3. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3
  4. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. (PMID: 16141203) Westin M.A. … Alexson S.E. (J. Biol. Chem. 2005) 3 23
  5. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions. (PMID: 10799608) Liu L.X. … Benarous R. (J. Virol. 2000) 3 23

Products for ACOT8 Gene

Sources for ACOT8 Gene

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