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ACOT8 Gene

protein-coding   GIFtS: 62
GCID: GC20M044470

Acyl-CoA Thioesterase 8

(Previous names: peroxisomal acyl-CoA thioesterase, peroxisomal acyl-CoA...)
(Previous symbol: PTE1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Thioesterase 81 2 3     hTE2 3
PTE11 2 3 5     Peroxisomal Acyl-CoA Thioesterase1
Peroxisomal Acyl-CoA Thioesterase 11 2     HNAACTE2
Choloyl-CoA Hydrolase1 2     Acyl-Coenzyme A Thioesterase 82
Choloyl-Coenzyme A Thioesterase2 3     HIV-Nef Associated Acyl-CoA Thioesterase2
Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 12 3     Long-Chain Fatty-Acyl-CoA Hydrolase2
Peroxisomal Long-Chain Acyl-CoA Thioesterase 12 3     Palmitoyl-CoA Hydrolase2
Thioesterase II2 3     Thioesterase III2
PTE-12 3     ACTEIII3
PTE-22 3     EC 3.1.2.273
PTE22 3     hACTEIII3
hACTE-III2 3     HIV-Nef-Associated Acyl-CoA Thioesterase3

External Ids:    HGNC: 159191   Entrez Gene: 100052   Ensembl: ENSG000001014737   OMIM: 6081235   UniProtKB: O147343   

Export aliases for ACOT8 gene to outside databases

Previous GC identifers: GC20M043904 GC20M041212


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACOT8 Gene:
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation
of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1
protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. (provided by RefSeq, Oct 2010)

GeneCards Summary for ACOT8 Gene:
ACOT8 (acyl-CoA thioesterase 8) is a protein-coding gene. Diseases associated with ACOT8 include von economo's disease, and hypertensive encephalopathy. GO annotations related to this gene include palmitoyl-CoA hydrolase activity and receptor binding.

UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes.
Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as
chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in
the metabolic regulation of peroxisome proliferation

Gene Wiki entry for ACOT8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT8 gene promoter:
         PPAR-alpha   USF-1   MyoD   MIF-1   Tal-1beta   c-Ets-1   Gfi-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT8 promoter sequence
   Search Chromatin IP Primers for ACOT8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

ACOT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT8 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044470:  view genomic region     (about GC identifiers)

Start:
44,470,360 bp from pter      End:
44,486,048 bp from pter
Size:
15,689 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 8  
Size: 319 amino acids; 35914 Da
Subunit: Interacts with HIV-1 Nef
Secondary accessions: O15261 Q17RX4

Explore the universe of human proteins at neXtProt for ACOT8: NX_O14734

Explore proteomics data for ACOT8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ACOT8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005460.2  
    ENSEMBL proteins: 
     ENSP00000217455   ENSP00000435581   ENSP00000435115   ENSP00000419403   ENSP00000434216  
     ENSP00000433923   ENSP00000431175   ENSP00000403862   ENSP00000416217  
    Reactome Protein details: O14734

    ACOT8 Human Recombinant Protein Products:

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    Novus Biologicals ACOT8 Proteins
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    ProSpec Recombinant Protein for ACOT8
    Cloud-Clone Corp. Proteins for ACOT8

    ACOT8 Antibody Products:

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    Cloud-Clone Corp. CLIAs for ACOT8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACOT: Acyl CoA thioesterases

    1 InterPro protein domain:
     IPR003703 Acyl_CoA_thio

    Graphical View of Domain Structure for InterPro Entry O14734

    ProtoNet protein and cluster: O14734

    1 Blocks protein domain: IPB003703 Acyl-CoA thioesterase

    UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734
    Similarity: Belongs to the C/M/P thioester hydrolase family


    ACOT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACOT8_HUMAN, O14734
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
    fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
    fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes.
    Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as
    chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in
    the metabolic regulation of peroxisome proliferation
    Catalytic activity: Choloyl-CoA + H(2)O = cholate + CoA
    Induction: Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated
    receptors (PPARs) (By similarity)

         Enzyme Number (IUBMB): EC 3.1.2.271

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0005515protein binding IPI--
    GO:0016290palmitoyl-CoA hydrolase activity IDA9299485
    GO:0033882choloyl-CoA hydrolase activity IEA--
    GO:0047617acyl-CoA hydrolase activity IDA10092594
         
    ACOT8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACOT8:
     Decreased Hepatitis C virus re 

         1 MGI phenotypic allele for Acot8 (no phenotypes)

    ACOT8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACOT8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACOT8

    miRNA
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    hsa-mir-335-5p (MIRT016798), hsa-mir-16-5p (MIRT031404)

    Block miRNA regulation of human, mouse, rat ACOT8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ACOT8:
    hsa-miR-130b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ACOT8 (NM_005469)
    Sino Biological Human cDNA Clone for ACOT8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACOT8_HUMAN, O14734: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome ----
    GO:0005782peroxisomal matrix TAS--

    ACOT8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACOT8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of bile acids and bile salts
    Synthesis of bile acids and bile salts0.88
    Bile acid and bile salt metabolism0.73
    Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol0.88
    Primary bile acid biosynthesis0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Peroxisomal lipid metabolism
    Peroxisomal lipid metabolism
    Beta-oxidation of very long chain fatty acids0.00
    Beta-oxidation of pristanoyl-CoA0.00
    4alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
    alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
    alpha-linolenic acid (ALA) metabolism0.00
    5Peroxisome
    Peroxisome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for ACOT8
        Beta-oxidation of very long chain fatty acids
    Beta-oxidation of pristanoyl-CoA
    Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    alpha-linolenic acid (ALA) metabolism


    3 Kegg Pathways  (Kegg details for ACOT8):
        Primary bile acid biosynthesis
    Metabolic pathways
    Peroxisome


    ACOT8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT8: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ACOT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ACOT8 (O147341, 3 ENSP000002174554) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    EIF2B1Q142323I2D: score=5 
    MARCH6O603373I2D: score=3 
    PRPF40AO754003I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006637acyl-CoA metabolic process IDA9299485
    GO:0006699bile acid biosynthetic process TAS--
    GO:0008206bile acid metabolic process TAS--
    GO:0016032viral process IEA--
    GO:0016559peroxisome fission IDA15194431

    ACOT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACOT8

    Selected HMDB Compounds for ACOT8 (see all 51)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    8,11,14-Eicosatrienoic acid(8Z,11Z,14Z)-Icosatrienoate (see all 34)1783-84-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--

    3 Novoseek inferred chemical compound relationships for ACOT8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acyl-coa 80.8 12 10944470 (5), 9299485 (1), 16141203 (1), 16061252 (1)
    tripeptide 56.8 1 10944470 (1)
    fatty acid 39.2 1 9299485 (1)



    ACOT8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ACOT8 gene (3 alternative transcripts): 
    NM_005469.3  NM_183385.1  NM_183386.1  

    Unigene Cluster for ACOT8:

    Acyl-CoA thioesterase 8
    Hs.444776  [show with all ESTs]
    Unigene Representative Sequence: AK126206
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217455(uc002xqa.2) ENST00000461272 ENST00000488679 ENST00000487205
    ENST00000484975 ENST00000493118(uc010zxe.2 uc002xqc.2 uc010zxf.2)
    ENST00000483141 ENST00000484783 ENST00000486165 ENST00000481938 ENST00000457981
    ENST00000426915
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ACOT8
      QuantiFast Probe-based Assays in human, mouse, rat ACOT8

    Additional mRNA sequence: 

    AF014404.1 AF124264.1 AK126206.1 AK292494.1 AK296973.1 AK298783.1 BC117155.1 BC117157.1 
    CR541771.1 CR541778.1 X86032.1 

    19 DOTS entries:

    DT.95336060  DT.447426  DT.97775420  DT.100812148  DT.100812145  DT.97852110  DT.120817181  DT.40221673 
    DT.95336063  DT.120817131  DT.120817515  DT.120817654  DT.75100429  DT.95078177  DT.100812152  DT.120817697 
    DT.120817794  DT.120817875  DT.97852086 

    Selected AceView cDNA sequences (see all 175):

    BM927419 CD674471 NM_005469 CN480815 AW015680 NM_183385 BM986979 BM551703 
    CA425098 CB123555 BE246518 AK126206 BQ920689 BM558216 BM980988 BI259172 
    BM669590 BU528923 BM723645 CD673016 BM810599 CB155430 BM916884 BQ934130 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACOT8 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                      -     -                                         -     -                           
    SP2:                                      -     -                                         -     -                           
    SP3:                                -     -     -                                                                           
    SP4:                                      -     -                                                                           
    SP5:                                      -                                                                                 


    ECgene alternative splicing isoforms for ACOT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACOT8 expression in normal human tissues (normalized intensities)      ACOT8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGGCTGTG
    ACOT8 Expression
    About this image


    ACOT8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ACOT8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444776

    UniProtKB/Swiss-Prot: ACOT8_HUMAN, O14734
    Tissue specificity: Detected in a T-cell line (at protein level). Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT8: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACOT8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot81 , 5 acyl-CoA thioesterase 81, 5 84.85(n)1
    84.95(a)1
      2 (85.27 cM)5
    1707891  NM_133240.21  NP_573503.21 
     1647927685 
    chicken
    (Gallus gallus)
    Aves ACOT81 acyl-CoA thioesterase 8 72.33(n)
    74.84(a)
      419303  XM_417475.4  XP_417475.3 
    lizard
    (Anolis carolinensis)
    Reptilia ACOT86
    acyl-CoA thioesterase 8
    68(a)
    1 ↔ 1
    GL344721.1(1-12550)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133252 Xenopus laevis transcribed sequence with weak similarity more 77.98(n)    BJ082654.1 
    zebrafish
    (Danio rerio)
    Actinopterygii acot81 acyl-CoA thioesterase 8 67.57(n)
    71.62(a)
      450052  NM_001006072.1  NP_001006072.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F25E2.31 F25E2.3 48.07(n)
    43.23(a)
      180429  NM_075758.5  NP_508159.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TES1(YJR019C)4 Peroxisomal acyl-CoA thioesterase likely to be involved more   --   10(468281-467232) 853477  NP_012553.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G017101 AT1G01710 50.66(n)
    43.32(a)
      839254  NM_100053.3  NP_563632.2 


    ENSEMBL Gene Tree for ACOT8 (if available)
    TreeFam Gene Tree for ACOT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACOT8 gene
    1 SIMAP similar gene for ACOT8 using alignment to 9 protein entries:     ACOT8_HUMAN (see all proteins):
    PTE1

    ACOT8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACOT8 (see all 274)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1976651,2
    C,F,A,H--44472479(-) ccaagC/Tgctct 1 -- int112Minor allele frequency- T:0.08NS EA NA WA CSA 687
    rs1450385921,2
    C--44472491(+) CTACA-/GTGTGTG 1 -- int10--------
    rs746942101,2
    C,F--44472524(+) GATGGC/TGACTT 1 -- int11Minor allele frequency- T:0.01EA 120
    rs342470321,2
    C,F--44472602(+) CAAAAG/AGGGTG 1 -- int14Minor allele frequency- A:0.08NA 126
    rs744346211,2
    C,F--44472612(+) GTCTTC/ATTCCA 1 -- int11Minor allele frequency- A:0.08WA 118
    rs1139428421,2
    C,F--44472708(+) GTGTCG/AGGATT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1433174891,2
    C--44472711(+) TCGGGA/GTTATA 1 -- int10--------
    rs3774500481,2
    C--44472734(+) TTCTCC/TCATGC 1 -- int10--------
    rs1916590331,2
    C--44472907(+) CAATAC/TAGCCC 2 Y C mis10--------
    rs1435289541,2
    C,F--44472913(+) AGCCCC/TGGGCT 2 Q R mis11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for ACOT8 (44470360 - 44486048 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ACOT8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458993CNV Loss19166990
    nsv833990CNV Loss17160897
    nsv517296CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACOT8
    DNA2.0 Custom Variant and Variant Library Synthesis for ACOT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608123    OMIM disorders: --

    12 diseases for ACOT8:    About MalaCards
    von economo's disease    hypertensive encephalopathy    plague    tonsillitis
    hypertension    hiv-1    tuberculosis    cerebritis
    thyroiditis    neuronitis    endotheliitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ACOT8:
    Plague

    ACOT8 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ACOT8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 10.9 2 10799608 (1), 10092594 (1)


    Export disorders for ACOT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACOT8 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ACOT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of peroxisomal acyl-CoA thioesterases in yeast and humans. (PubMed id 10092594)1, 2, 3, 9 Jones J.M.... Gould S.J. (J. Biol. Chem. 1999)
    2. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. (PubMed id 9153233)1, 2, 3 Liu L.X.... Benichou S. (J. Biol. Chem. 1997)
    3. A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef. (PubMed id 9299485)1, 2, 9 Watanabe H.... Saito T. (Biochem. Biophys. Res. Commun. 1997)
    4. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PubMed id 16940157)1, 3 Hunt M.C.... Alexson S.E.H. (FASEB J. 2006)
    5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (J. Lipid Res. 2005)
    6. Overexpression of human acyl-CoA thioesterase upregulates peroxisome biogenesis. (PubMed id 15194431)1, 2 Ishizuka M.... Saito T. (Exp. Cell Res. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism. (PubMed id 11755680)1, 2 Hunt M.C. and Alexson S.E.H. (Prog. Lipid Res. 2002)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PubMed id 10944470)1, 9 Jones J.M. and Gould S.J. (Biochem. Biophys. Res. Commun. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10005 HGNC: 15919 AceView: PTE1 Ensembl:ENSG00000101473 euGenes: HUgn10005
    ECgene: ACOT8 Kegg: 10005 H-InvDB: ACOT8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACOT8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACOT8 gene:
    Search GeneIP for patents involving ACOT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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