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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACOT7 Gene

protein-coding   GIFtS: 60
GCID: GC01M006324

acyl-CoA thioesterase 7
 Explore 6 diseases affiliated with
ACOT7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ACOT7    

Aliases
for ACOT7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Acyl-CoA Thioesterase 71 2 3     CTE-IIa2 3
BACH1 2 3 5     EC 3.1.2.23 8
CTE-II1 2 3     LACH2 5
ACH11 2     MGC11261
ACT1 2     RP1-120G22.102
LACH11 2     Acyl-CoA Thioesterase 22
HBACH1     Acyl-CoA Thioesterase, Long Chain2
Brain Acyl-CoA Hydrolase2 3     Brain Acyl CoA Hydrolase2
Long Chain Acyl-CoA Thioester Hydrolase2 3     Cytosolic Acyl Coenzyme A Thioester Hydrolase2

External Ids:    HGNC: 241571   Entrez Gene: 113322   Ensembl: ENSG000000970217   OMIM: 6025875   UniProtKB: O001543   

Export aliases for ACOT7 gene to outside databases

Previous GC identifers: GC01M006259 GC01M005472


Summaries
for ACOT7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ACOT7:
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of
palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial
temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different
subcellular locations have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BACH_HUMAN, O00154
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty
acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids
and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the
cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid
metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with
chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA

Gene Wiki entry for ACOT7


Genomic Views
for ACOT7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACOT7 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACOT7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACOT7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACOT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36

ACOT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006324:  view genomic region     (about GC identifiers)

Start:
 6,324,332 bp from pter      End:
 6,454,451 bp from pter
Size:
 130,120 bases      Orientation:
 minus strand

Proteins
for ACOT7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BACH_HUMAN, O00154 (See protein sequence)
Recommended Name: Cytosolic acyl coenzyme A thioester hydrolase  
Size: 380 amino acids; 41796 Da
Subunit: Homohexamer (By similarity)
Subcellular location: Isoform 4: Cytoplasm
Subcellular location: Isoform 6: Cytoplasm
Subcellular location: Isoform 1: Mitochondrion
Subcellular location: Isoform 5: Mitochondrion
Sequence caution: Sequence=AAB61211.1; Type=Frameshift; Positions=371; Sequence=AAH17365.2; Type=Erroneous initiation;
Sequence=CAI19435.1; Type=Erroneous initiation; Sequence=CAI19774.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ACOT7:
2QQ2 (3D)    
Secondary accessions: A8K0K7 A8K232 A8K6B8 A8K837 O43703 Q53Y78 Q5JYL2 Q5JYL3 Q5JYL4 Q5JYL5 Q5JYL6
Q5TGR4 Q9UJM9 Q9Y539 Q9Y540
Alternative splicing: 6 isoforms:  O00154-1   O00154-2   O00154-3   O00154-4   O00154-5   O00154-6   (Major isoform)

Explore the universe of human proteins at neXtProt for ACOT7: NX_O00154

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00154

    • 4 DME Specific Peptides for ACOT7 (O00154)
     AARHCKTN  EIEVLVDAD  RCVAALARVE  TISGRMTFTSNKS 

    ACOT7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_009205.3  NP_863654.1  NP_863655.1  NP_863656.1  

    ENSEMBL proteins: 
     ENSP00000367073   ENSP00000367076   ENSP00000367086   ENSP00000367091   ENSP00000402532  
     ENSP00000354615   ENSP00000465719   ENSP00000439218   ENSP00000441872  

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    Novus Biologicals ACOT7 Proteins
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    ProSpec Recombinant Protein for ACOT7
    Uscn Proteins for ACOT7

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10578051
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--
    GO:0043005neuron projection IEA--
    GO:0044297cell body IEA--


    ACOT7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ACOT7

    Protein Domains /
    Families
    for ACOT7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ACOT7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006683 Thioestr_supf

    Graphical View of Domain Structure for InterPro Entry O00154

    ProtoNet protein and cluster: O00154

    UniProtKB/Swiss-Prot: BACH_HUMAN, O00154
    Domain: Both hydrolase domains are required for efficient activity (By similarity)
    Similarity: Contains 2 acyl coenzyme A hydrolase domains


    Function
    for ACOT7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BACH_HUMAN, O00154
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty
    acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids
    and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the
    cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid
    metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with
    chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA
    Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate

    Enzyme Number (IUBMB): EC 3.1.2.21 2

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ACOT7 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000062fatty-acyl-CoA binding TAS10578051
    GO:0003824catalytic activity TAS10578051
    GO:0004091carboxylesterase activity IEA--
    GO:0016290palmitoyl-CoA hydrolase activity IEA--
    GO:0047617acyl-CoA hydrolase activity ----


    ACOT7 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Acot7 (no phenotypes)

    ACOT7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ACOT7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Biosynthesis of unsaturated fatty acids
    		Biosynthesis of unsaturated fatty acids1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for ACOT7):
        Biosynthesis of unsaturated fatty acids


    ACOT7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACOT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for ACOT7 (O001542, 3 ENSP000003670864) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2869773 I2D: score=3 STRING: ENSP00000244769
    C12orf44Q9BSB43I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    DLG4P783523I2D: score=1 
    FOXO3O435243I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS10578051
    GO:0009062fatty acid catabolic process IEA--


    ACOT7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ACOT7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACOT7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACOT7

    10/67 HMDB Compounds for ACOT7 (see all 67)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    11'-Carboxy-alpha-chromanol2,5,7,8-Tetramethyl-2-(4',8'-dimethyl-11'-carboxy-undecyl)-6-chromanol;RRR-11'-carboxy-alpha-chromanol;2-(11-carboxy-4,8-dimethylundecyl)-6-hydroxy-2,5,7,8-tetramethylchroman;11'-carboxy-alpha-tocopherol ----
    11'-Carboxy-alpha-tocotrienolalpha-CDMD(en)(2)HC;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,5,7,8-tetramethylchroman;alpha-CDMD(en)(,2)HC ----
    11'-Carboxy-gama-chromanol2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-chromanol;2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-hydroxychroman;RRR-11'-carboxy-gama-chromanol;11'-Carboxy-gama-tocopherol ----
    11'-carboxy-gama-tocotrienolgama-CDMD(en)(2)HC;carboxydimethyldecadienyl hydroxychroman;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,7,8-trimethylchroman ----
    13'-carboxy-alpha-tocotrienol13AaTE ----
    2 Novoseek chemical compound relationships for ACOT7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acyl-coa 79.5 7 12435388 (2), 10578051 (1), 15638818 (1), 8631842 (1)
    fatty acid 36.9 5 17514357 (2)

    Search CenterWatch for drugs/clinical trials and news about ACOT7 / BACH 

    Transcripts
    for ACOT7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ACOT7 gene (6 alternative transcripts): 
    NM_007274.3  NM_181864.2  NM_181865.2  NM_181866.2  NM_181862.2  NM_181863.2  

    Unigene Cluster for ACOT7:

    Acyl-CoA thioesterase 7
    Hs.126137  [show with all ESTs]
    Unigene Representative Sequence: BC017365
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377842(uc001amq.3) ENST00000377845(uc001amr.3) ENST00000377855(uc001ams.3)
    ENST00000377860 ENST00000418124 ENST00000361521(uc001amt.3 uc001amu.3)
    ENST00000473466 ENST00000481175 ENST00000545482 ENST00000541130

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    hsa-miR-21* hsa-miR-588 hsa-miR-200a hsa-miR-4263 hsa-miR-548s hsa-miR-646 hsa-miR-3926 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmid: ACOT7 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB074417.1 AB074418.1 AB074419.1 AK057168.1 AK289572.1 AK290097.1 AK291583.1 AK292202.1 
    AK300831.1 AK304465.1 BC017365.2 BT006888.1 D88894.2 

    13 DOTS entries:

    DT.449444  DT.100882148  DT.87017261  DT.87017263  DT.100882155  DT.100882133  DT.121351036  DT.95361277 
    DT.95361290  DT.121274009  DT.121351044  DT.100882139  DT.121351082 

    24/350 AceView cDNA sequences (see all 350):

    NM_181864 CR620600 AB074416 BU615739 BE260742 BM471423 CR599443 BM917120 
    BM781830 BQ674600 BU165694 BM782731 BX341888 BX463526 BM807217 BM543268 
    BI858286 BG577061 CR608567 CR617887 NM_181865 BX104820 BQ961863 CR603255 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACOT7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:              -     -     -                                               -           -                                       
    SP2:              -     -     -                                               -           -     -                                 
    SP3:              -     -     -                                               -           -     -     -                           
    SP4:                          -                                               -           -     -     -                           
    SP5:                                                                          -           -     -     -                           


    ECgene alternative splicing isoforms for ACOT7

    Expression
    for ACOT7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACOT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAACGGGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ACOT7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ACOT7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACOT7

    SOURCE GeneReport for Unigene cluster: Hs.126137

    UniProtKB/Swiss-Prot: BACH_HUMAN, O00154
    Tissue specificity: Isoform 4 is expressed exclusively in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including ACOT7: 
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    Orthologs
    for ACOT7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ACOT7 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ACOT71 acyl-CoA thioesterase 7 80.34(n)
    83.28(a)    		   419371  XM_003642533.1  XP_003642581.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ACOT76
    		 --
    		 74(a)
    		 1 ↔ 1
    		 AAWZ02039297(2649-7410)
    zebrafish
    (Danio rerio)    		 Actinopterygii acot71 acyl-CoA thioesterase 7 74.9(n)
    84.06(a)    		   447878  NM_001004617.1  NP_001004617.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yciA6
    		 Acyl-CoA esterase, role unknown
    		 23(a)
    		 1 → many
    		 Chromosome(1309872-1310270)


    ENSEMBL Gene Tree for ACOT7 (if available)
    TreeFam Gene Tree for ACOT7 (if available) 

    Paralogs
    for ACOT7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACOT7 gene
    ACOT112  ACOT122  
    1 SIMAP similar gene for ACOT7 using alignment to 4 protein entries:     BACH_HUMAN (see all proteins):
    ACOT7L

    ACOT7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACOT7
    PGOHUM00000250705


    Genomic Variants
    for ACOT7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2393 NCBI SNPs in ACOT7 are shown (see all 2393)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs120618481,2
    		--5472939(+) TATTGA/CCTGGG 1 -- us2k10--------
    rs120597711,2
    		--5472940(+) ATTGAC/TTGGGC 1 -- us2k10--------
    rs1127551581,2
    		--5472993(+) ACAGGG/TGGCAG 1 -- us2k12Minor allele frequency- T:0.33CSA 3
    rs740495161,2
    		C,F,--5473012(+) AGAGGA/GGACAC 1 -- us2k14Minor allele frequency- G:0.06WA CSA 124
    rs740495171,2
    		C,F,--5473029(+) CATGGC/AGGGTC 1 -- us2k14Minor allele frequency- A:0.05WA CSA NA 127
    rs120631571,2
    		C,F,A,H,--5473069(+) TGACAT/CCCTCT 1 -- us2k119Minor allele frequency- C:0.06NS EA NA WA CSA 2245
    rs8461051,2
    		C,F,H--5473240(-) TCTGCG/AGGGTG 1 -- us2k19Minor allele frequency- A:0.01NA EA MN NS 660
    rs740495181,2
    		C,F,--5473241(+) ACCCCG/ACAGAG 1 -- us2k15Minor allele frequency- A:0.05WA CSA NA EA 362
    rs120599241,2
    		A,--5473290(+) AGAGAA/CGTGGG 1 -- us2k10--------
    rs792434111,2
    		F,--5473324(+) CGCCCC/TGGAGA 1 -- us2k12Minor allele frequency- T:0.01NA EA 240

    HapMap Linkage Disequilibrium report for ACOT7 (6324332 - 6454451 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ACOT7
         3 CNVs: 70625 65456 4200

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    Disorders / Diseases
    for ACOT7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ACOT7 for disorders           About GeneDecksing

    OMIM gene information: 602587    OMIM disorders: --

    6 diseases for ACOT7:    About MalaCards
    temporal lobe epilepsy    fatty acid oxidation disorders    meckel's diverticulum    kidney disease
    ataxia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ACOT7 (3 documents)

    Export disorders for ACOT7 gene to outside databases

    Publications
    for ACOT7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACOT7 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with ACOT7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. (PubMed id 10578051)1, 2, 3, 9 Yamada J.... Suga T. (1999)
    2. Human brain acyl-CoA hydrolase isoforms encoded by a single gene. (PubMed id 12435388)1, 2, 9 Yamada J.... Suga T. (2002)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy. (PubMed id 15592755)1, 9 Yang J.W....Lubec G. (2004)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    External Searches for ACOT7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ACOT7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11332 HGNC: 24157 AceView: BACH Ensembl:ENSG00000097021 euGenes: HUgn11332
    ECgene: ACOT7 Kegg: 11332 H-InvDB: ACOT7

    Other Databases showing ACOT7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ACOT7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACOT7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACOT7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ACOT7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ACOT7 gene:
    Search GeneIP for patents involving ACOT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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