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ACOT7 Gene

protein-coding   GIFtS: 62
GCID: GC01M006324

Acyl-CoA Thioesterase 7

  See ACOT7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Thioesterase 71 2 3     LACH2 5
BACH2 3 5     ACH12
Brain Acyl CoA Hydrolase1 2     ACT2
Brain Acyl-CoA Hydrolase2 3     LACH12
Long Chain Acyl-CoA Thioester Hydrolase2 3     Acyl-CoA Thioesterase 22
CTE-II2 3     Acyl-CoA Thioesterase, Long Chain2
CTE-IIa2 3     Cytosolic Acyl Coenzyme A Thioester Hydrolase2
EC 3.1.2.23 8     hBACH2

External Ids:    HGNC: 241571   Entrez Gene: 113322   Ensembl: ENSG000000970217   OMIM: 6025875   UniProtKB: O001543   

Export aliases for ACOT7 gene to outside databases

Previous GC identifers: GC01M006259 GC01M005472


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACOT7 Gene:
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of
palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial
temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different
subcellular locations have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACOT7 Gene:
ACOT7 (acyl-CoA thioesterase 7) is a protein-coding gene. Diseases associated with ACOT7 include fatty acid oxidation disorders, and temporal lobe epilepsy. GO annotations related to this gene include and palmitoyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot: BACH_HUMAN, O00154
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by
modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the
substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active
towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA

Gene Wiki entry for ACOT7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT7 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT7 promoter sequence
   Search Chromatin IP Primers for ACOT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36

ACOT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006324:  view genomic region     (about GC identifiers)

Start:
6,324,329 bp from pter      End:
6,454,451 bp from pter
Size:
130,123 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BACH_HUMAN, O00154 (See protein sequence)
Recommended Name: Cytosolic acyl coenzyme A thioester hydrolase  
Size: 380 amino acids; 41796 Da
Subunit: Homohexamer (By similarity)
Sequence caution: Sequence=AAB61211.1; Type=Frameshift; Positions=371; Sequence=AAH17365.2; Type=Erroneous
initiation; Sequence=CAI19435.1; Type=Erroneous initiation; Sequence=CAI19774.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ACOT7:
2QQ2 (3D)    
Secondary accessions: A8K0K7 A8K232 A8K6B8 A8K837 B3KQ12 O43703 Q53Y78 Q5JYL2 Q5JYL3 Q5JYL4
Q5JYL5 Q5JYL6 Q5TGR4 Q9UJM9 Q9Y539 Q9Y540
Alternative splicing: 7 isoforms:  O00154-1   O00154-2   O00154-3   O00154-4   O00154-5   O00154-6   O00154-7   (Major isoform)

Explore the universe of human proteins at neXtProt for ACOT7: NX_O00154

Explore proteomics data for ACOT7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys157, Lys283
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ACOT7 (O00154)
     AARHCKTN  EIEVLVDAD  RCVAALARVE  TISGRMTFTSNKS 


    See ACOT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_009205.3  NP_863654.1  NP_863655.1  NP_863656.1  

    ENSEMBL proteins: 
     ENSP00000476610   ENSP00000367073   ENSP00000367076   ENSP00000367086   ENSP00000367091  
     ENSP00000402532   ENSP00000354615   ENSP00000465719   ENSP00000439218   ENSP00000441872  

    ACOT7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for ACOT7
    OriGene Protein Over-expression Lysate for ACOT7
    OriGene MassSpec for ACOT7
    OriGene Custom Protein Services for ACOT7
    GenScript Custom Purified and Recombinant Proteins Services for ACOT7
    Novus Biologicals ACOT7 Proteins
    Novus Biologicals ACOT7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ACOT7
    Cloud-Clone Corp. Proteins for ACOT7

     
    Search eBioscience for Proteins for ACOT7 

    ACOT7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ACOT7
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    ThermoFisher Antibody for ACOT7
    LSBio Antibodies in human, mouse, rat for ACOT7

    ACOT7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACOT7
    Cloud-Clone Corp. CLIAs for ACOT7
    Search eBioscience for ELISAs for ACOT7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACOT: Acyl CoA thioesterases

    1 InterPro protein domain:
     IPR006683 Thioestr_supf

    Graphical View of Domain Structure for InterPro Entry O00154

    ProtoNet protein and cluster: O00154

    UniProtKB/Swiss-Prot: BACH_HUMAN, O00154
    Domain: Both hydrolase domains are required for efficient activity (By similarity)
    Similarity: Contains 2 acyl coenzyme A hydrolase domains


    Find genes that share domains with ACOT7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BACH_HUMAN, O00154
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
    fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
    fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by
    modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the
    substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active
    towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA
    Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate

         Enzyme Number (IUBMB): EC 3.1.2.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000062fatty-acyl-CoA binding IDA10578051
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI10578051
    GO:0016290palmitoyl-CoA hydrolase activity IDA10578051
    GO:0036042long-chain fatty acyl-CoA binding IDA10578051
         
    Find genes that share ontologies with ACOT7           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acot7):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  liver/biliary system 
     nervous system 

    Find genes that share phenotypes with ACOT7           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACOT7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACOT7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACOT7

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACOT7:
    hsa-mir-1229-3p (MIRT036298), hsa-mir-324-3p (MIRT042814), hsa-mir-18a-3p (MIRT040899), hsa-mir-155-5p (MIRT020748)

    Block miRNA regulation of human, mouse, rat ACOT7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACOT7 (see all 10):
    hsa-miR-21* hsa-miR-588 hsa-miR-200a hsa-miR-4263 hsa-miR-548s hsa-miR-646 hsa-miR-3926 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidACOT7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACOT7
    Predesigned siRNA for gene silencing in human, mouse, rat ACOT7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACOT7

    Clone
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    OriGene ORF clones in mouse, rat for ACOT7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ACOT7 (NM_181865)
    Sino Biological Human cDNA Clone for ACOT7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ACOT7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT7

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12054) for ACOT7 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BACH_HUMAN, O00154: Isoform 4: Cytoplasm
    BACH_HUMAN, O00154: Isoform 6: Cytoplasm
    BACH_HUMAN, O00154: Isoform 1: Mitochondrion
    BACH_HUMAN, O00154: Isoform 5: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IDA10578051

    Find genes that share ontologies with ACOT7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACOT7 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    Fatty acid elongation0.38


    Find genes that share SuperPaths with ACOT7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for ACOT7):
        Fatty acid elongation
    Biosynthesis of unsaturated fatty acids

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT7: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ACOT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACOT7 (O001542, 3 ENSP000003670864) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2869773 I2D: score=3 STRING: ENSP00000244769
    ATG101Q9BSB43I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    DLG4P783523I2D: score=1 
    FOXO3O435243I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009062fatty acid catabolic process IEA--
    GO:0015937coenzyme A biosynthetic process IDA10578051
    GO:0036114medium-chain fatty-acyl-CoA catabolic process IDA10578051
    GO:0036116long-chain fatty-acyl-CoA catabolic process IDA10578051
    GO:0051792medium-chain fatty acid biosynthetic process IDA10578051

    Find genes that share ontologies with ACOT7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACOT7 (BACH)

    Selected HMDB Compounds for ACOT7 (see all 67)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    11'-Carboxy-alpha-chromanol2,5,7,8-Tetramethyl-2-(4',8'-dimethyl-11'-carboxy-undecyl)-6-chromanol;RRR-11'-carboxy-alpha-chromanol;2-(11-carboxy-4,8-dimethylundecyl)-6-hydroxy-2,5,7,8-tetramethylchroman;11'-carboxy-alpha-tocopherol ----
    11'-Carboxy-alpha-tocotrienolalpha-CDMD(en)(2)HC;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,5,7,8-tetramethylchroman;alpha-CDMD(en)(,2)HC ----
    11'-Carboxy-gama-chromanol2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-chromanol;2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-hydroxychroman;RRR-11'-carboxy-gama-chromanol;11'-Carboxy-gama-tocopherol ----
    11'-carboxy-gama-tocotrienolgama-CDMD(en)(2)HC;carboxydimethyldecadienyl hydroxychroman;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,7,8-trimethylchroman ----
    13'-carboxy-alpha-tocotrienol13AaTE ----

    2 Novoseek inferred chemical compound relationships for ACOT7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acyl-coa 79.5 7 12435388 (2), 10578051 (1), 15638818 (1), 8631842 (1)
    fatty acid 36.9 5 17514357 (2)



    Find genes that share compounds with ACOT7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACOT7 gene (6 alternative transcripts): 
    NM_007274.3  NM_181864.2  NM_181865.2  NM_181866.2  NM_181862.2  NM_181863.2  

    Unigene Cluster for ACOT7:

    Acyl-CoA thioesterase 7
    Hs.126137  [show with all ESTs]
    Unigene Representative Sequence: BC017365
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608083 ENST00000377842(uc001amq.3) ENST00000377845(uc001amr.3)
    ENST00000377855(uc001ams.3) ENST00000377860 ENST00000418124 ENST00000361521(uc001amt.3 uc001amu.3)
    ENST00000473466 ENST00000481175 ENST00000545482 ENST00000541130
    miRNA
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    Block miRNA regulation of human, mouse, rat ACOT7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACOT7 (see all 10):
    hsa-miR-21* hsa-miR-588 hsa-miR-200a hsa-miR-4263 hsa-miR-548s hsa-miR-646 hsa-miR-3926 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidACOT7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ACOT7
    Clone
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    OriGene ORF clones in mouse, rat for ACOT7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ACOT7 (NM_181865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACOT7
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACOT7
      QuantiTect SYBR Green Assays in human, mouse, rat ACOT7
      QuantiFast Probe-based Assays in human, mouse, rat ACOT7
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12054) for ACOT7 

    Additional mRNA sequence: 

    AB074417.1 AB074418.1 AB074419.1 AK057168.1 AK289572.1 AK290097.1 AK291583.1 AK292202.1 
    AK300831.1 AK304465.1 BC017365.2 BT006888.1 D88894.2 

    13 DOTS entries:

    DT.449444  DT.100882148  DT.87017261  DT.87017263  DT.100882155  DT.100882133  DT.121351036  DT.95361277 
    DT.95361290  DT.121274009  DT.121351044  DT.100882139  DT.121351082 

    Selected AceView cDNA sequences (see all 350):

    CR603255 BM709633 T32226 BX356771 BM983541 CR593786 BM807217 CR608567 
    AU076557 CR597165 BM905705 AB074415 CB125794 CD556620 BQ689972 CR620600 
    BG577061 NM_181865 CR599569 BU160271 BG200112 BM762704 CR615031 CR604226 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACOT7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:              -     -     -                                               -           -                                       
    SP2:              -     -     -                                               -           -     -                                 
    SP3:              -     -     -                                               -           -     -     -                           
    SP4:                          -                                               -           -     -     -                           
    SP5:                                                                          -           -     -     -                           


    ECgene alternative splicing isoforms for ACOT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ACOT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAACGGGCC
    ACOT7 Expression
    About this image


    ACOT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ACOT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126137

    UniProtKB/Swiss-Prot: BACH_HUMAN, O00154
    Tissue specificity: Isoform 4 is expressed exclusively in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT7: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ACOT7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot71 , 5 acyl-CoA thioesterase 71, 5 87.9(n)1
    94.64(a)1
      4 (82.93 cM)5
    700251  NM_133348.21  NP_579926.21 
     1521781345 
    chicken
    (Gallus gallus)
    Aves ACOT71 acyl-CoA thioesterase 7 77.46(n)
    79.72(a)
      419371  XM_417533.4  XP_417533.4 
    lizard
    (Anolis carolinensis)
    Reptilia ACOT76
    acyl-CoA thioesterase 7
    74(a)
    1 ↔ 1
    AAWZ02039297(2649-7410)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017327161 cytosolic acyl coenzyme A thioester hydrolase-like 71.01(n)
    81.52(a)
      101732716  XM_004916190.1  XP_004916247.1 
    zebrafish
    (Danio rerio)
    Actinopterygii acot71 acyl-CoA thioesterase 7 74.9(n)
    84.06(a)
      447878  NM_001004617.1  NP_001004617.1 


    ENSEMBL Gene Tree for ACOT7 (if available)
    TreeFam Gene Tree for ACOT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACOT7 gene
    1 SIMAP similar gene for ACOT7 using alignment to 4 protein entries:     BACH_HUMAN (see all proteins):
    ACOT7L

    Find genes that share paralogs with ACOT7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ACOT7
    PGOHUM00000250705


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACOT7 (see all 2815)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503392881,2
    --6323872(+) GGGTCA/GGGGTG 4 -- ds50010--------
    rs1915086991,2
    C--6323945(+) TTTCCC/TAGCAG 4 -- ds50010--------
    rs562401151,2
    C,F--6324077(+) CCAGCA/GTCTGG 4 -- ds50013Minor allele frequency- G:0.11WA CSA 122
    rs1123267981,2
    C--6324331(+) CGTGGC/G/TTCCAG 4 -- ds50011CSA 1
    rs10441541,2
    C--6324360(-) CCAGCA/CCCACT 4 -- ut313Minor allele frequency- C:0.00MN NA 188
    rs771202391,2
    C,F--6324386(+) TACAGC/TGTGCT 4 -- ut311Minor allele frequency- T:0.05WA 118
    rs758501891,2
    C,F--6324435(+) GCGCTC/TGGGAC 4 -- ut311Minor allele frequency- T:0.07WA 118
    rs1154226631,2
    C,F--6324436(+) CGCTCG/AGGACA 4 -- ut311Minor allele frequency- A:0.01WA 118
    rs1484266921,2
    C--6327836(+) GCTGTA/GTGCCC 4 -- int10--------
    rs1425784321,2
    C--6327913(+) TGAATC/TCTGAT 4 -- int10--------

    HapMap Linkage Disequilibrium report for ACOT7 (6324329 - 6454451 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ACOT7 (see all 33):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739695CNV Deletion23290073
    esv2740028CNV Deletion23290073
    esv2678076CNV Deletion23128226
    dgv11e199CNV Deletion23128226
    esv2739917CNV Deletion23290073
    esv2739806CNV Deletion23290073
    esv2678878CNV Deletion23128226
    nsv508825CNV Insertion20534489
    nsv523989CNV Loss19592680
    dgv124n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602587    OMIM disorders: --

    2 diseases for ACOT7:    
    About MalaCards
    fatty acid oxidation disorders    temporal lobe epilepsy


    Find genes that share disorders with ACOT7           About GenesLikeMe

    Genetic Association Database (GAD): ACOT7
    Human Genome Epidemiology (HuGE) Navigator: ACOT7 (3 documents)

    Export disorders for ACOT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACOT7 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with ACOT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. (PubMed id 10578051)1, 2, 3, 9 Yamada J.... Suga T. (J. Biochem. 1999)
    2. Human brain acyl-CoA hydrolase isoforms encoded by a single gene. (PubMed id 12435388)1, 2, 9 Yamada J.... Suga T. (Biochem. Biophys. Res. Commun. 2002)
    3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 4 Newton-Cheh C.... Stricker B.H. (Nat. Genet. 2009)
    6. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (J. Lipid Res. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11332 HGNC: 24157 AceView: BACH Ensembl:ENSG00000097021 euGenes: HUgn11332
    ECgene: ACOT7 Kegg: 11332 H-InvDB: ACOT7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACOT7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACOT7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACOT7 gene:
    Search GeneIP for patents involving ACOT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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