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Aliases for ACOT7 Gene

Aliases for ACOT7 Gene

  • Acyl-CoA Thioesterase 7 2 3 4
  • BACH 3 4 6
  • Long Chain Acyl-CoA Thioester Hydrolase 3 4
  • Brain Acyl CoA Hydrolase 2 3
  • Brain Acyl-CoA Hydrolase 3 4
  • EC 3.1.2.2 4 63
  • CTE-IIa 3 4
  • CTE-II 3 4
  • LACH 3 6
  • Cytosolic Acyl Coenzyme A Thioester Hydrolase 3
  • Acyl-CoA Thioesterase, Long Chain 3
  • Acyl-CoA Thioesterase 2 3
  • LACH1 3
  • HBACH 3
  • ACH1 3
  • ACT 3

External Ids for ACOT7 Gene

Previous GeneCards Identifiers for ACOT7 Gene

  • GC01M006259
  • GC01M005472

Summaries for ACOT7 Gene

Entrez Gene Summary for ACOT7 Gene

  • This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACOT7 Gene

ACOT7 (Acyl-CoA Thioesterase 7) is a Protein Coding gene. Diseases associated with ACOT7 include fatty acid oxidation disorders and temporal lobe epilepsy. Among its related pathways are Biosynthesis of unsaturated fatty acids and Biosynthesis of unsaturated fatty acids. GO annotations related to this gene include palmitoyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot for ACOT7 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA

Gene Wiki entry for ACOT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT7 Gene

Genomics for ACOT7 Gene

Regulatory Elements for ACOT7 Gene

Genomic Location for ACOT7 Gene

Start:
6,264,269 bp from pter
End:
6,394,391 bp from pter
Size:
130,123 bases
Orientation:
Minus strand

Genomic View for ACOT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT7 Gene

Proteins for ACOT7 Gene

  • Protein details for ACOT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00154-BACH_HUMAN
    Recommended name:
    Cytosolic acyl coenzyme A thioester hydrolase
    Protein Accession:
    O00154
    Secondary Accessions:
    • A8K0K7
    • A8K232
    • A8K6B8
    • A8K837
    • B3KQ12
    • O43703
    • Q53Y78
    • Q5JYL2
    • Q5JYL3
    • Q5JYL4
    • Q5JYL5
    • Q5JYL6
    • Q5TGR4
    • Q9UJM9
    • Q9Y539
    • Q9Y540

    Protein attributes for ACOT7 Gene

    Size:
    380 amino acids
    Molecular mass:
    41796 Da
    Quaternary structure:
    • Homohexamer.
    SequenceCaution:
    • Sequence=AAB61211.1; Type=Frameshift; Positions=371; Evidence={ECO:0000305}; Sequence=AAH17365.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19435.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19774.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACOT7 Gene

    Alternative splice isoforms for ACOT7 Gene

neXtProt entry for ACOT7 Gene

Proteomics data for ACOT7 Gene at MOPED

Selected DME Specific Peptides for ACOT7 Gene

Post-translational modifications for ACOT7 Gene

  • Ubiquitination at Lys157 and Lys283
  • Modification sites at PhosphoSitePlus

Domains for ACOT7 Gene

Gene Families for ACOT7 Gene

HGNC:
  • ACOT :Acyl CoA thioesterases

Protein Domains for ACOT7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O00154

UniProtKB/Swiss-Prot:

BACH_HUMAN :
  • O00154
Domain:
  • Both hydrolase domains are required for efficient activity.
  • Contains 2 acyl coenzyme A hydrolase domains.
genes like me logo Genes that share domains with ACOT7: view

Function for ACOT7 Gene

Molecular function for ACOT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + H(2)O = CoA + palmitate
UniProtKB/Swiss-Prot Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA

Enzyme Numbers (IUBMB) for ACOT7 Gene

Gene Ontology (GO) - Molecular Function for ACOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IDA 10578051
GO:0005515 protein binding IPI 10578051
GO:0016290 palmitoyl-CoA hydrolase activity IDA 10578051
GO:0036042 long-chain fatty acyl-CoA binding IDA 10578051
GO:0042803 protein homodimerization activity IPI 10578051
genes like me logo Genes that share ontologies with ACOT7: view
genes like me logo Genes that share phenotypes with ACOT7: view

miRNA for ACOT7 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACOT7 Gene

Localization for ACOT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT7 Gene

Isoform 4: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 1: Mitochondrion.
Isoform 5: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT7 Gene COMPARTMENTS Subcellular localization image for ACOT7 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ACOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA 10578051
genes like me logo Genes that share ontologies with ACOT7: view

Pathways for ACOT7 Gene

genes like me logo Genes that share pathways with ACOT7: view

Pathways by source for ACOT7 Gene

Gene Ontology (GO) - Biological Process for ACOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009062 fatty acid catabolic process IEA --
GO:0015937 coenzyme A biosynthetic process IDA 10578051
GO:0036114 medium-chain fatty-acyl-CoA catabolic process IDA 10578051
GO:0036116 long-chain fatty-acyl-CoA catabolic process IDA 10578051
GO:0051792 medium-chain fatty acid biosynthetic process IDA 10578051
genes like me logo Genes that share ontologies with ACOT7: view

Compounds for ACOT7 Gene

(67) HMDB Compounds for ACOT7 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(2) Novoseek inferred chemical compound relationships for ACOT7 Gene

Compound -log(P) Hits PubMed IDs
acyl-coa 79.5 5
fatty acid 36.9 2
genes like me logo Genes that share compounds with ACOT7: view

Transcripts for ACOT7 Gene

Unigene Clusters for ACOT7 Gene

Acyl-CoA thioesterase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - -
SP9: -

Relevant External Links for ACOT7 Gene

GeneLoc Exon Structure for
ACOT7
ECgene alternative splicing isoforms for
ACOT7

Expression for ACOT7 Gene

mRNA expression in normal human tissues for ACOT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOT7 Gene

This gene is overexpressed in Brain - Cortex (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOT7 Gene

SOURCE GeneReport for Unigene cluster for ACOT7 Gene Hs.126137

mRNA Expression by UniProt/SwissProt for ACOT7 Gene

O00154-BACH_HUMAN
Tissue specificity: Isoform 4 is expressed exclusively in brain.
genes like me logo Genes that share expressions with ACOT7: view

Orthologs for ACOT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACOT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT7 35
  • 99.47 (n)
  • 99.74 (a)
ACOT7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACOT7 35
  • 89.85 (n)
  • 94.03 (a)
ACOT7 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOT7 35
  • 87.28 (n)
  • 91.28 (a)
ACOT7 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acot7 35
  • 87.9 (n)
  • 94.64 (a)
Acot7 16
Acot7 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACOT7 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACOT7 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acot7 35
  • 87.8 (n)
  • 94.05 (a)
chicken
(Gallus gallus)
Aves ACOT7 35
  • 77.46 (n)
  • 79.72 (a)
ACOT7 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOT7 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732716 35
  • 71.01 (n)
  • 81.52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8265 35
zebrafish
(Danio rerio)
Actinopterygii acot7 35
  • 74.9 (n)
  • 84.06 (a)
acot7 36
  • 72 (a)
OneToOne
Species with no ortholog for ACOT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOT7 Gene

ENSEMBL:
Gene Tree for ACOT7 (if available)
TreeFam:
Gene Tree for ACOT7 (if available)

Paralogs for ACOT7 Gene

Selected SIMAP similar genes for ACOT7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ACOT7 Gene

genes like me logo Genes that share paralogs with ACOT7: view

No data available for Paralogs for ACOT7 Gene

Variants for ACOT7 Gene

Sequence variations from dbSNP and Humsavar for ACOT7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs722333 -- 6,351,154(-) TGGGT(C/T)GCTGG intron-variant
rs732404 -- 6,279,631(-) TGATG(A/G)ATGAG intron-variant
rs735546 -- 6,356,474(-) GCAGg(A/T)gctga intron-variant
rs742503 -- 6,348,980(-) TTCTG(G/T)GGCCT intron-variant
rs742504 -- 6,348,214(+) CAGGC(A/G)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT7 Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294
dgv8n67 CNV Gain 20364138
nsv508825 CNV Insertion 20534489
nsv871569 CNV Loss 21882294
dgv122n71 CNV Loss 21882294
dgv123n71 CNV Loss 21882294
nsv871646 CNV Loss 21882294
dgv124n71 CNV Loss 21882294
nsv871266 CNV Loss 21882294
nsv526371 CNV Loss 19592680
nsv871324 CNV Loss 21882294
nsv965 CNV Loss 18451855
nsv871117 CNV Loss 21882294
nsv519253 CNV Loss 19592680
esv2739695 CNV Deletion 23290073
esv2739806 CNV Deletion 23290073
esv2678878 CNV Deletion 23128226
esv24092 CNV Loss 19812545
nsv522013 CNV Loss 19592680
esv2739917 CNV Deletion 23290073
esv2740028 CNV Deletion 23290073
nsv521525 CNV Loss 19592680
nsv1076 CNV Loss 18451855
dgv125n71 CNV Loss 21882294
nsv523989 CNV Loss 19592680
dgv11e199 CNV Deletion 23128226
esv2678076 CNV Deletion 23128226
esv21684 CNV Loss 19812545

Relevant External Links for ACOT7 Gene

HapMap Linkage Disequilibrium report
ACOT7
Human Gene Mutation Database (HGMD)
ACOT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT7 Gene

Disorders for ACOT7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ACOT7 Gene including...

Search for ACOT7 Gene in MalaCards »

Relevant External Links for ACOT7

Genetic Association Database (GAD)
ACOT7
Human Genome Epidemiology (HuGE) Navigator
ACOT7
genes like me logo Genes that share disorders with ACOT7: view

No data available for UniProtKB/Swiss-Prot for ACOT7 Gene

Publications for ACOT7 Gene

  1. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. (PMID: 10578051) Yamada J. … Suga T. (J. Biochem. 1999) 2 3 4 23
  2. Human brain acyl-CoA hydrolase isoforms encoded by a single gene. (PMID: 12435388) Yamada J. … Suga T. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  3. Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy. (PMID: 15592755) Yang J.W. … Lubec G. (Amino Acids 2004) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ACOT7 Gene

  • antibodies-online proteins for ACOT7
  • antibodies-online antibodies for ACOT7
  • antibodies-online kits for ACOT7

Sources for ACOT7 Gene

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