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Aliases for ACOT6 Gene

Aliases for ACOT6 Gene

  • Acyl-CoA Thioesterase 6 2 3
  • Putative Acyl-CoA Thioesterase 6 3 4
  • C14orf42 3 4
  • Putative Acyl-Coenzyme A Thioesterase 6 3
  • Chromosome 14 Open Reading Frame 42 2
  • EC 3.1.2.2 63
  • EC 3.1.2.- 4
  • C14_5530 3

External Ids for ACOT6 Gene

Previous Symbols for ACOT6 Gene

  • C14orf42

Summaries for ACOT6 Gene

GeneCards Summary for ACOT6 Gene

ACOT6 (Acyl-CoA Thioesterase 6) is a Protein Coding gene. An important paralog of this gene is ACOT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT6 Gene

Genomics for ACOT6 Gene

Genomic Location for ACOT6 Gene

Start:
73,610,945 bp from pter
End:
73,619,888 bp from pter
Size:
8,944 bases
Orientation:
Plus strand

Genomic View for ACOT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT6 Gene

Regulatory Elements for ACOT6 Gene

Proteins for ACOT6 Gene

  • Protein details for ACOT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3I5F7-ACOT6_HUMAN
    Recommended name:
    Putative acyl-coenzyme A thioesterase 6
    Protein Accession:
    Q3I5F7
    Secondary Accessions:

    Protein attributes for ACOT6 Gene

    Size:
    207 amino acids
    Molecular mass:
    22991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACOT6 Gene

Proteomics data for ACOT6 Gene at MOPED

Selected DME Specific Peptides for ACOT6 Gene

Post-translational modifications for ACOT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ACOT6 Gene

Gene Families for ACOT6 Gene

HGNC:
  • ACOT :Acyl CoA thioesterases

Protein Domains for ACOT6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACOT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3I5F7

UniProtKB/Swiss-Prot:

ACOT6_HUMAN
Family:
  • Belongs to the C/M/P thioester hydrolase family.:
    • Q3I5F7
genes like me logo Genes that share domains with ACOT6: view

Function for ACOT6 Gene

Enzyme Numbers (IUBMB) for ACOT6 Gene

Gene Ontology (GO) - Molecular Function for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT6: view

miRNA for ACOT6 Gene

miRTarBase miRNAs that target ACOT6

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACOT6 Gene

Localization for ACOT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT6 Gene COMPARTMENTS Subcellular localization image for ACOT6 gene
Compartment Confidence
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16940157
genes like me logo Genes that share ontologies with ACOT6: view

Pathways for ACOT6 Gene

SuperPathways for ACOT6 Gene

No Data Available

Interacting Proteins for ACOT6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370531%0d%0a9606.ENSP00000467024%0d%0a
Selected Interacting proteins: ENSP00000370531 for ACOT6 Gene via STRING

Symbol External ID(s) Details
RAD23A

Gene Ontology (GO) - Biological Process for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ACOT6: view

No data available for Pathways by source for ACOT6 Gene

Compounds for ACOT6 Gene

(1) HMDB Compounds for ACOT6 Gene

Compound Synonyms Cas Number PubMed IDs
Docosanoyl-CoA
  • behenoyl-CoA
Not Available
genes like me logo Genes that share compounds with ACOT6: view

Transcripts for ACOT6 Gene

mRNA/cDNA for ACOT6 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT6 Gene

Acyl-CoA thioesterase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT6 Gene

No ASD Table

Relevant External Links for ACOT6 Gene

GeneLoc Exon Structure for
ACOT6
ECgene alternative splicing isoforms for
ACOT6

Expression for ACOT6 Gene

mRNA expression in normal human tissues for ACOT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOT6 Gene

This gene is overexpressed in Liver (8.3).

SOURCE GeneReport for Unigene cluster for ACOT6 Gene Hs.122038

genes like me logo Genes that share expressions with ACOT6: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for ACOT6 Gene

Orthologs for ACOT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT6 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACOT6 36
  • 38 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOT6 36
  • 36 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acot6 16
Acot6 36
  • 34 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACOT6 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-11e23.3 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C31H5.6 36
  • 10 (a)
ManyToMany
K05B2.4 36
  • 11 (a)
ManyToMany
T05E7.1 36
  • 9 (a)
ManyToMany
W03D8.8 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
  • 12 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 10 (a)
ManyToMany
Species with no ortholog for ACOT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT6 Gene

ENSEMBL:
Gene Tree for ACOT6 (if available)
TreeFam:
Gene Tree for ACOT6 (if available)

Paralogs for ACOT6 Gene

Paralogs for ACOT6 Gene

Selected SIMAP similar genes for ACOT6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOT6: view

Variants for ACOT6 Gene

Sequence variations from dbSNP and Humsavar for ACOT6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2215013 -- 73,618,129(-) tttca(C/T)tcttg intron-variant
rs5809620 -- 73,617,916(+) GGCGG(-/G)CAGAT intron-variant
rs5809621 -- 73,617,974(+) CCCCA(-/TC)TCTAC intron-variant
rs7143627 -- 73,618,387(+) TCGTC(A/G)GTGTA intron-variant
rs8021357 -- 73,617,915(+) caagg(C/T)gggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT6 Gene

Variant ID Type Subtype PubMed ID
dgv641e1 CNV Complex 17122850
nsv428295 CNV Gain 18775914
nsv832828 CNV Gain+Loss 17160897
esv2677257 CNV Deletion 23128226

Relevant External Links for ACOT6 Gene

HapMap Linkage Disequilibrium report
ACOT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT6 Gene

Disorders for ACOT6 Gene

No disorders were found for ACOT6 Gene.

No data available for UniProtKB/Swiss-Prot for ACOT6 Gene

Publications for ACOT6 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4
  2. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 3

Products for ACOT6 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Fatty Acid Metabolism in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ACOT6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ACOT6
    • Block miRNA regulation of ACOT6 using miScript Target Protectors

    Sources for ACOT6 Gene

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