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Aliases for ACOT6 Gene

Aliases for ACOT6 Gene

  • Acyl-CoA Thioesterase 6 2 3 5
  • Putative Acyl-CoA Thioesterase 6 3 4
  • C14orf42 3 4
  • Putative Acyl-Coenzyme A Thioesterase 6 3
  • Chromosome 14 Open Reading Frame 42 2
  • EC 61
  • EC 3.1.2.- 4
  • C14_5530 3

External Ids for ACOT6 Gene

Previous HGNC Symbols for ACOT6 Gene

  • C14orf42

Previous GeneCards Identifiers for ACOT6 Gene

  • GC14U900539
  • GC14P073153
  • GC14P074083
  • GC14P054251

Summaries for ACOT6 Gene

GeneCards Summary for ACOT6 Gene

ACOT6 (Acyl-CoA Thioesterase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include carboxylic ester hydrolase activity. An important paralog of this gene is ACOT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT6 Gene

Genomics for ACOT6 Gene

Regulatory Elements for ACOT6 Gene

Enhancers for ACOT6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F073611 1.1 Ensembl ENCODE 0.8 +1.8 1756 1.8 TBP ARID4B SIN3A ZNF48 YY1 GTF3C2 GLIS2 ZNF207 MIXL1 SP5 LOC100420966 ELMSAN1 RBM25 ACOT4 LOC100506476 ACOT6 GC14P073623
GH14F073613 0.6 ENCODE 0.8 +2.8 2815 0.1 SOX13 SOX5 FOXA3 ETV4 ZKSCAN8 ACOT6 GC14P073623
GH14F073602 0.6 ENCODE 0.4 -8.6 -8614 0.2 GATA3 JUND ESRRA CTBP1 DPF2 ACOT6 ACOT4
GH14F073591 0.8 ENCODE 0.3 -18.9 -18875 1.2 GTF2F1 CTCF MAX SIN3A EBF1 RAD21 ZBTB40 E2F1 CTBP1 ELK1 ACOT4 NUMB LOC100506476 ACOT1 DNAL1 ACOT6
GH14F073599 0.2 ENCODE 0.4 -11.2 -11213 1.1 RNU6-240P PTGR2 ENSG00000223300 LOC100506476 ACOT2 ACOT4 ACOT6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACOT6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOT6 Gene

73,610,945 bp from pter
73,619,908 bp from pter
8,964 bases
Plus strand

Genomic View for ACOT6 Gene

Genes around ACOT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT6 Gene

Proteins for ACOT6 Gene

  • Protein details for ACOT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative acyl-coenzyme A thioesterase 6
    Protein Accession:

    Protein attributes for ACOT6 Gene

    207 amino acids
    Molecular mass:
    22991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACOT6 Gene

Selected DME Specific Peptides for ACOT6 Gene


Post-translational modifications for ACOT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACOT6 Gene

Gene Families for ACOT6 Gene

Protein Domains for ACOT6 Gene


Suggested Antigen Peptide Sequences for ACOT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the C/M/P thioester hydrolase family.
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT6: view

Function for ACOT6 Gene

Enzyme Numbers (IUBMB) for ACOT6 Gene

Gene Ontology (GO) - Molecular Function for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT6: view
genes like me logo Genes that share phenotypes with ACOT6: view

Animal Model Products

miRNA for ACOT6 Gene

miRTarBase miRNAs that target ACOT6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOT6 Gene

Localization for ACOT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT6 gene
Compartment Confidence
peroxisome 5
cytosol 5
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol IDA 16940157
genes like me logo Genes that share ontologies with ACOT6: view

Pathways & Interactions for ACOT6 Gene

genes like me logo Genes that share pathways with ACOT6: view

Interacting Proteins for ACOT6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000370531 Q3I5F7-ACOT6_HUMAN for ACOT6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IBA --
GO:0006637 acyl-CoA metabolic process IBA --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with ACOT6: view

No data available for SIGNOR curated interactions for ACOT6 Gene

Drugs & Compounds for ACOT6 Gene

(1) Additional Compounds for ACOT6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Behenoyl-CoA
  • Behenoyl-Coenzyme A
genes like me logo Genes that share compounds with ACOT6: view

Transcripts for ACOT6 Gene

mRNA/cDNA for ACOT6 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT6 Gene

Acyl-CoA thioesterase 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT6 Gene

No ASD Table

Relevant External Links for ACOT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACOT6 Gene

mRNA differential expression in normal tissues according to GTEx for ACOT6 Gene

This gene is overexpressed in Liver (x8.3).

NURSA nuclear receptor signaling pathways regulating expression of ACOT6 Gene:


SOURCE GeneReport for Unigene cluster for ACOT6 Gene:

genes like me logo Genes that share expression patterns with ACOT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ACOT6 Gene

Orthologs for ACOT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACOT6 35
  • 97 (a)
(Bos Taurus)
Mammalia ACOT6 35
  • 38 (a)
(Canis familiaris)
Mammalia ACOT6 35
  • 36 (a)
(Mus musculus)
Mammalia Acot6 35
  • 34 (a)
(Monodelphis domestica)
Mammalia ACOT6 35
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
-- 35
  • 27 (a)
(Gallus gallus)
Aves -- 35
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 28 (a)
(Danio rerio)
Actinopterygii si:dkey-11e23.3 35
  • 21 (a)
(Caenorhabditis elegans)
Secernentea K05B2.4 35
  • 11 (a)
W03D8.8 35
  • 11 (a)
C31H5.6 35
  • 10 (a)
T05E7.1 35
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
-- 35
  • 14 (a)
-- 35
  • 13 (a)
-- 35
  • 13 (a)
-- 35
  • 13 (a)
-- 35
  • 12 (a)
-- 35
  • 10 (a)
-- 35
-- 35
-- 35
Species where no ortholog for ACOT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT6 Gene

Gene Tree for ACOT6 (if available)
Gene Tree for ACOT6 (if available)

Paralogs for ACOT6 Gene

Paralogs for ACOT6 Gene

(3) SIMAP similar genes for ACOT6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOT6: view

Variants for ACOT6 Gene

Sequence variations from dbSNP and Humsavar for ACOT6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10047916 -- 73,620,031(+) CTCAG(A/C)CTCCC intron-variant, downstream-variant-500B
rs10136341 -- 73,616,752(+) TACAC(A/G)GATGA intron-variant, upstream-variant-2KB
rs10145553 -- 73,616,157(+) agaga(C/T)gggtc intron-variant, upstream-variant-2KB
rs10150828 -- 73,610,781(+) tagaa(C/T)gtgct intron-variant, upstream-variant-2KB
rs111344855 -- 73,613,025(+) TGCCG(C/T)CGGAT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ACOT6 Gene

Variant ID Type Subtype PubMed ID
nsv832828 CNV gain+loss 17160897
nsv428295 CNV gain 18775914
nsv1053281 CNV gain 25217958
nsv1035460 CNV gain 25217958
esv3892561 CNV gain 25118596
esv2759996 CNV gain 17122850
esv2677257 CNV deletion 23128226

Variation tolerance for ACOT6 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT6 Gene

Disorders for ACOT6 Gene

Relevant External Links for ACOT6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACOT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOT6 Gene

Publications for ACOT6 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4 64
  2. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3 64
  3. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ACOT6 Gene

Sources for ACOT6 Gene

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