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ACOT4 Gene

protein-coding   GIFtS: 55
GCID: GC14P074058

Acyl-CoA Thioesterase 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Thioesterase 41 2 3     EC 3.1.2.23 8
Peroxisomal Acyl Coenzyme A Thioester Hydrolase Ib2 3     PTE1B2
Peroxisomal Long-Chain Acyl-CoA Thioesterase Ib2 3     Acyl-Coenzyme A Thioesterase 42
PTE-2b2 3     Peroxisomal Acyl-CoA Thioesterase 2B2
PTE-Ib2 3     PTEIB3
PTE2B2 3     

External Ids:    HGNC: 197481   Entrez Gene: 1229702   Ensembl: ENSG000001774657   OMIM: 6143145   UniProtKB: Q8N9L93   

Export aliases for ACOT4 gene to outside databases

Previous GC identifers: GC14P073129 GC14P054227


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ACOT4 Gene:
ACOT4 (acyl-CoA thioesterase 4) is a protein-coding gene. GO annotations related to this gene include palmitoyl-CoA hydrolase activity and receptor binding. An important paralog of this gene is ACOT6.

UniProtKB/Swiss-Prot: ACOT4_HUMAN, Q8N9L9
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and
unsaturated monocarboxylic acyl-CoAs

Gene Wiki entry for ACOT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT4 gene promoter:
         AREB6   PPAR-alpha   Pax-3   AML1a   Pax-5   ARP-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT4 promoter sequence
   Search Chromatin IP Primers for ACOT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.1

ACOT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P074058:  view genomic region     (about GC identifiers)

Start:
74,058,410 bp from pter      End:
74,063,200 bp from pter
Size:
4,791 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ACOT4_HUMAN, Q8N9L9 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 4  
Size: 421 amino acids; 46327 Da
Miscellaneous: Human ACOT4 may have acquired the combined activities of mouse ACOT3, ACOT4, and ACOT5
1 PDB 3D structure from and Proteopedia for ACOT4:
3K2I (3D)    
Secondary accessions: Q17RF4 Q5BKT6 Q86TX0 Q86TX1 Q96N88

Explore the universe of human proteins at neXtProt for ACOT4: NX_Q8N9L9

Explore proteomics data for ACOT4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACOT4 (Q8N9L9) (see all 6)
     IEPPYFP  PALGGSF  VELEVLDGH  LRDEKGALFRA 


    See ACOT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689544.3  
    ENSEMBL proteins: 
     ENSP00000323071  

    ACOT4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACOT: Acyl CoA thioesterases

    3 InterPro protein domains:
     IPR006862 Thio_Ohase/aa_AcTrfase
     IPR014940 BAAT_C
     IPR016662 Acyl-CoA_thioEstase_long-chain

    Graphical View of Domain Structure for InterPro Entry Q8N9L9

    ProtoNet protein and cluster: Q8N9L9

    1 Blocks protein domain: IPB006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

    UniProtKB/Swiss-Prot: ACOT4_HUMAN, Q8N9L9
    Similarity: Belongs to the C/M/P thioester hydrolase family


    Find genes that share domains with ACOT4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACOT4_HUMAN, Q8N9L9
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
    fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
    fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and
    unsaturated monocarboxylic acyl-CoAs
    Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate
    Biophysicochemical properties: Kinetic parameters: KM=14 uM for succinyl-CoA; KM=147 uM for glutaryl-CoA; KM=3.4
    uM for C14-acyl-CoA; Vmax=581 nmol/min/mg enzyme toward succinyl-CoA; Vmax=132 nmol/min/mg enzyme toward
    glutaryl-CoA; Vmax=137 nmol/min/mg enzyme toward C14-acyl-CoA;

         Enzyme Number (IUBMB): EC 3.1.2.21 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004778succinyl-CoA hydrolase activity IDA16141203
    GO:0005102receptor binding IPI--
    GO:0016290palmitoyl-CoA hydrolase activity IEA--
    GO:0016790thiolester hydrolase activity ----
    GO:0047617acyl-CoA hydrolase activity IDA16141203
         
    Find genes that share ontologies with ACOT4           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Acot4 (no phenotypes)

    Find genes that share phenotypes with ACOT4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ACOT4

    miRNA
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    miRTarBase miRNAs that target ACOT4:
    hsa-mir-7-5p (MIRT025674), hsa-mir-335-5p (MIRT016879)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACOT4_HUMAN, Q8N9L9: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol2
    cytoskeleton1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome IDA16141203

    Find genes that share ontologies with ACOT4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACOT4 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    oleate biosynthesis II (animals)0.32
    Fatty acid elongation0.38
    2Metabolism
    Metabolic pathways0.38
    3stearate biosynthesis I (animals)
    stearate biosynthesis I (animals)0.35
    4palmitate biosynthesis I (animals)
    palmitate biosynthesis I (animals)


    Find genes that share SuperPaths with ACOT4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ACOT4
        stearate biosynthesis I (animals)
    oleate biosynthesis II (animals)
    palmitate biosynthesis I (animals)



    3 Kegg Pathways  (Kegg details for ACOT4):
        Fatty acid elongation
    Biosynthesis of unsaturated fatty acids
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACOT4
    Interactions:

        Search GeneGlobe Interaction Network for ACOT4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ACOT4 (ENSP000003230714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FADS1ENSP000003222294STRING: ENSP00000322229
    SCD5ENSP000003163294STRING: ENSP00000316329
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process IDA16940157
    GO:0001676long-chain fatty acid metabolic process IDA16940157
    GO:0006104succinyl-CoA metabolic process IDA16940157
    GO:0006637acyl-CoA metabolic process IDA16940157
    GO:0019605NOT butyrate metabolic process IDA16940157

    Find genes that share ontologies with ACOT4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ACOT4

    Selected HMDB Compounds for ACOT4 (see all 66)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    11'-Carboxy-alpha-chromanol2,5,7,8-Tetramethyl-2-(4',8'-dimethyl-11'-carboxy-undecyl)-6-chromanol;RRR-11'-carboxy-alpha-chromanol;2-(11-carboxy-4,8-dimethylundecyl)-6-hydroxy-2,5,7,8-tetramethylchroman;11'-carboxy-alpha-tocopherol ----
    11'-Carboxy-alpha-tocotrienolalpha-CDMD(en)(2)HC;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,5,7,8-tetramethylchroman;alpha-CDMD(en)(,2)HC ----
    11'-Carboxy-gama-chromanol2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-chromanol;2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-hydroxychroman;RRR-11'-carboxy-gama-chromanol;11'-Carboxy-gama-tocopherol ----
    11'-carboxy-gama-tocotrienolgama-CDMD(en)(2)HC;carboxydimethyldecadienyl hydroxychroman;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,7,8-trimethylchroman ----
    13'-carboxy-alpha-tocotrienol13AaTE ----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACOT4 gene: 
    NM_152331.3  

    Unigene Cluster for ACOT4:

    Acyl-CoA thioesterase 4
    Hs.49433  [show with all ESTs]
    Unigene Representative Sequence: AK055797
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000326303(uc001xoo.3)
    miRNA
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    Additional mRNA sequence: 

    AK055797.1 AK094223.1 BC031799.1 BC090945.1 BC117341.1 BC117343.1 BX248023.1 BX248047.1 

    2 DOTS entries:

    DT.100030638  DT.443254 

    Selected AceView cDNA sequences (see all 35):

    BX248047 BX248023 BM712466 BM675989 CA421441 BI762267 NM_152331 BC031799 
    AA947131 BE892339 AI126271 BG285738 BG741318 AK055797 AI830209 AA046424 
    AA056177 BX353531 BX357727 AK094223 BX095309 AA858013 BX353530 AA302899 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACOT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTGTCAT
    ACOT4 Expression
    About this image


    ACOT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    ACOT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49433

    UniProtKB/Swiss-Prot: ACOT4_HUMAN, Q8N9L9
    Tissue specificity: Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ACOT4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot41 , 5 acyl-CoA thioesterase 41, 5 81.31(n)1
    74.35(a)1
      12 (39.01 cM)5
    1712821  NM_134247.31  NP_599008.31 
     840383795 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    57(a)
    1 → many
    5(25464271-25468294)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    1 → many
    1(39211695-39218982)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-11e23.46
    zgc:1015536
    (see all 5)
    zgc:101553
    (see all 5)
    42(a)
    31(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    20(28961321-28964638) ENSDARG00000042510
    25(32692330-32717304) ENSDARG00000040427
    worm
    (Caenorhabditis elegans)
    Secernentea W03D8.86
    K05B2.46
    (see all 4)
    Protein K05B2.4 (K05B2.4) mRNA, complete cds
    (see all 4)
    29(a)
    27(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    I(2791689-2794895) WBGene00020989
    X(4919020-4920988) WBGene00019404


    ENSEMBL Gene Tree for ACOT4 (if available)
    TreeFam Gene Tree for ACOT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACOT4 gene
    ACOT62  ACOT12  ACOT22  BAAT2  
    4 SIMAP similar genes for ACOT4 using alignment to 1 protein entry:     ACOT4_HUMAN:
    ACOT2    ACOT1    ACOT6    BAAT

    Find genes that share paralogs with ACOT4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ACOT4
    PGOHUM00000234674


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACOT4 (see all 214)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158260891,2
    F--74056430(+) TTGGTC/GTCACT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1397723871,2
    C--74056464(+) CCCTCC/GCGGAG 1 -- us2k10--------
    rs1493879741,2
    C--74056469(+) GCGGAG/TATGTT 1 -- us2k10--------
    rs751668251,2
    C,F--74056525(+) TCCCAT/CGTGCT 1 -- us2k11Minor allele frequency- C:0.14WA 118
    rs71402981,2
    C,F,A,H--74056564(+) GGTCTT/CGCTGG 1 -- us2k18Minor allele frequency- C:0.15NA CSA EA 257
    rs125884331,2
    C,F,A,H--74056575(+) ctcagA/Gagtga 1 -- us2k14Minor allele frequency- G:0.10NA EA 132
    rs1181310411,2
    C,F--74056600(+) GCGGTG/AAGTGT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs71609711,2
    C,F,A,H--74056604(+) tgagtG/Attaca 1 -- us2k110Minor allele frequency- A:0.28NA WA CSA EA 377
    rs1462902601,2
    C--74056620(+) TAAGGC/TGGCAT 1 -- us2k10--------
    rs1395185311,2
    --74056628(+) CATGTC/TTGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACOT4 (74058410 - 74063200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ACOT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1958n71CNV Gain21882294
    nsv428295CNV Gain18775914
    nsv832828CNV Gain+Loss17160897
    dgv641e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614314    OMIM disorders: --


    Find genes that share disorders with ACOT4           About GenesLikeMe


    Export disorders for ACOT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACOT4 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ACOT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PubMed id 16940157)1, 2, 3 Hunt M.C.... Alexson S.E.H. (FASEB J. 2006)
    2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (J. Lipid Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. (PubMed id 16141203)1, 9 Westin M.A....Alexson S.E. (J. Biol. Chem. 2005)
    6. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)- Pex5p affinities. (PubMed id 20178365)1 Ghosh D. and Berg J.M. (J. Am. Chem. Soc. 2010)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PubMed id 10944470)1 Jones J.M. and Gould S.J. (Biochem. Biophys. Res. Commun. 2000)
    10. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. (PubMed id 10567408)1 Hunt M.C....Alexson S.E. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 122970 HGNC: 19748 AceView: PTE2B Ensembl:ENSG00000177465 euGenes: HUgn122970
    ECgene: ACOT4 Kegg: 122970 H-InvDB: ACOT4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ACOT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACOT4 gene:
    Search GeneIP for patents involving ACOT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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