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Aliases for ACOT4 Gene

Aliases for ACOT4 Gene

  • Acyl-CoA Thioesterase 4 2 3 4 5
  • Peroxisomal Acyl Coenzyme A Thioester Hydrolase Ib 3 4
  • Peroxisomal Long-Chain Acyl-CoA Thioesterase Ib 3 4
  • EC 3.1.2.2 4 61
  • PTE-2b 3 4
  • PTE-Ib 3 4
  • PTE2B 3 4
  • Peroxisomal Acyl-CoA Thioesterase 2B 3
  • Acyl-Coenzyme A Thioesterase 4 3
  • PTE1B 3
  • PTEIB 4

External Ids for ACOT4 Gene

Previous GeneCards Identifiers for ACOT4 Gene

  • GC14P073129
  • GC14P074058
  • GC14P054227

Summaries for ACOT4 Gene

GeneCards Summary for ACOT4 Gene

ACOT4 (Acyl-CoA Thioesterase 4) is a Protein Coding gene. Among its related pathways are Fatty acid elongation and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT1.

UniProtKB/Swiss-Prot for ACOT4 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.

Gene Wiki entry for ACOT4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT4 Gene

Genomics for ACOT4 Gene

Regulatory Elements for ACOT4 Gene

Enhancers for ACOT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G073591 0.8 ENCODE 16.8 +0.4 365 1.2 SIN3A RAD21 ZBTB40 YY1 ELK1 ZNF143 ZNF207 HCFC1 ELF1 GATAD2B ACOT4 NUMB LOC100506476 ACOT1 DNAL1 ACOT6
GH14G073611 1.2 Ensembl ENCODE 10.8 +21.0 21047 1.7 ARID4B SIN3A ZNF48 YY1 GTF3C2 GLIS2 ZNF207 SP5 NFYC ZNF579 LOC100420966 ELMSAN1 RBM25 ACOT4 LOC100506476 ACOT6 GC14P073623
GH14G072848 0.6 dbSUPER 4.4 -742.2 -742234 1.0 NR2F1 MAX NR2F2 ZFHX2 EGR1 ATF3 NR2F6 HNF4A EGR2 DPF3 DCAF4 ACOT4 GC14M072854 ENSG00000206751 GC14M072730
GH14G073599 0.2 ENCODE 4.8 +8.0 8027 1.1 RNU6-240P PTGR2 ENSG00000223300 LOC100506476 ACOT2 ACOT4 ACOT6
GH14G073602 0.6 ENCODE 0.4 +10.6 10626 0.2 CTBP1 ESRRA GATA3 JUND RCOR1 DPF2 ACOT6 ACOT4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACOT4 on UCSC Golden Path with GeneCards custom track

Promoters for ACOT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070647 295 1200 SIN3A RAD21 ZBTB40 YY1 ELK1 ZNF143 ZNF207 HCFC1 ELF1 GATAD2B

Genomic Location for ACOT4 Gene

Chromosome:
14
Start:
73,591,706 bp from pter
End:
73,596,496 bp from pter
Size:
4,791 bases
Orientation:
Plus strand

Genomic View for ACOT4 Gene

Genes around ACOT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT4 Gene

Proteins for ACOT4 Gene

  • Protein details for ACOT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9L9-ACOT4_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 4
    Protein Accession:
    Q8N9L9
    Secondary Accessions:
    • Q17RF4
    • Q5BKT6
    • Q86TX0
    • Q86TX1
    • Q96N88

    Protein attributes for ACOT4 Gene

    Size:
    421 amino acids
    Molecular mass:
    46327 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Human ACOT4 may have acquired the combined activities of mouse ACOT3, ACOT4, and ACOT5.

    Three dimensional structures from OCA and Proteopedia for ACOT4 Gene

neXtProt entry for ACOT4 Gene

Selected DME Specific Peptides for ACOT4 Gene

Q8N9L9:
  • GRVRATLFLPP
  • VELEVLDGH
  • VKGPGIGLLGIS
  • IEPPYFP
  • LRDEKGALFRA
  • PALGGSF

Post-translational modifications for ACOT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACOT4 Gene

Gene Families for ACOT4 Gene

Suggested Antigen Peptide Sequences for ACOT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9L9

UniProtKB/Swiss-Prot:

ACOT4_HUMAN :
  • Belongs to the C/M/P thioester hydrolase family.
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT4: view

Function for ACOT4 Gene

Molecular function for ACOT4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=14 uM for succinyl-CoA {ECO:0000269 PubMed:16940157}; KM=147 uM for glutaryl-CoA {ECO:0000269 PubMed:16940157}; KM=3.4 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=581 nmol/min/mg enzyme toward succinyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=132 nmol/min/mg enzyme toward glutaryl-CoA {ECO:0000269 PubMed:16940157}; Vmax=137 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate.
UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.

Enzyme Numbers (IUBMB) for ACOT4 Gene

Gene Ontology (GO) - Molecular Function for ACOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004778 succinyl-CoA hydrolase activity IDA 16141203
GO:0005102 receptor binding IPI 20178365
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT4: view
genes like me logo Genes that share phenotypes with ACOT4: view

Animal Models for ACOT4 Gene

MGI Knock Outs for ACOT4:

Animal Model Products

CRISPR Products

miRNA for ACOT4 Gene

miRTarBase miRNAs that target ACOT4

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACOT4 Gene

Localization for ACOT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT4 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT4 gene
Compartment Confidence
peroxisome 5
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ACOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA,IEA 16141203
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with ACOT4: view

Pathways & Interactions for ACOT4 Gene

genes like me logo Genes that share pathways with ACOT4: view

Gene Ontology (GO) - Biological Process for ACOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006104 succinyl-CoA metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process IDA,TAS --
GO:0019605 NOT butyrate metabolic process IDA 16940157
genes like me logo Genes that share ontologies with ACOT4: view

No data available for SIGNOR curated interactions for ACOT4 Gene

Drugs & Compounds for ACOT4 Gene

(12) Drugs for ACOT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Gamma-Homolinolenic acid Approved Nutra 0
Icosapent Approved Nutra Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 0

(42) Additional Compounds for ACOT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT4: view

Transcripts for ACOT4 Gene

mRNA/cDNA for ACOT4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT4 Gene

Acyl-CoA thioesterase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT4 Gene

No ASD Table

Relevant External Links for ACOT4 Gene

GeneLoc Exon Structure for
ACOT4
ECgene alternative splicing isoforms for
ACOT4

Expression for ACOT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACOT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOT4 Gene

This gene is overexpressed in Liver (x8.4) and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for ACOT4 Gene

This gene is overexpressed in Heart (39.0), Placenta (11.0), and Testis (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACOT4 Gene



Protein tissue co-expression partners for ACOT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACOT4 Gene:

ACOT4

SOURCE GeneReport for Unigene cluster for ACOT4 Gene:

Hs.49433

mRNA Expression by UniProt/SwissProt for ACOT4 Gene:

Q8N9L9-ACOT4_HUMAN
Tissue specificity: Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle.

Evidence on tissue expression from TISSUES for ACOT4 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Kidney(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ACOT4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOT4 Gene

Orthologs for ACOT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT4 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia ACOT4 34 35
  • 87.11 (n)
cow
(Bos Taurus)
Mammalia ACOT4 34
  • 86.27 (n)
MGC160092 35
  • 83 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Acot4 34
  • 82.03 (n)
mouse
(Mus musculus)
Mammalia Acot4 34 16 35
  • 81.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-11e23.4 35
  • 42 (a)
ManyToMany
zgc:101553 35
  • 31 (a)
ManyToMany
si:dkey-183c16.7 35
  • 30 (a)
ManyToMany
si:dkeyp-89c11.3 35
  • 30 (a)
ManyToMany
si:dkeyp-89c11.1 35
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea W03D8.8 35
  • 29 (a)
ManyToMany
K05B2.4 35
  • 27 (a)
ManyToMany
C31H5.6 35
  • 26 (a)
ManyToMany
T05E7.1 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
Species where no ortholog for ACOT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT4 Gene

ENSEMBL:
Gene Tree for ACOT4 (if available)
TreeFam:
Gene Tree for ACOT4 (if available)

Paralogs for ACOT4 Gene

Paralogs for ACOT4 Gene

(4) SIMAP similar genes for ACOT4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ACOT4 Gene

genes like me logo Genes that share paralogs with ACOT4: view

Variants for ACOT4 Gene

Sequence variations from dbSNP and Humsavar for ACOT4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000172637 -- 73,590,448(+) GGTGG(A/C)GCTGC intron-variant, upstream-variant-2KB
rs1000236440 -- 73,591,535(+) AGACT(C/T)TGTTT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000562894 -- 73,591,231(+) GACAG(A/G)GAGAG intron-variant, upstream-variant-2KB
rs1000696111 -- 73,596,091(+) CATTA(C/T)AAACG intron-variant, downstream-variant-500B
rs1000912901 -- 73,591,512(+) CACTC(C/T)AGCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ACOT4 Gene

Variant ID Type Subtype PubMed ID
esv2759996 CNV gain 17122850
esv3892561 CNV gain 25118596
esv3892562 CNV gain 25118596
nsv1035460 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv428295 CNV gain 18775914
nsv832828 CNV gain+loss 17160897

Variation tolerance for ACOT4 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.67; 89.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT4 Gene

Human Gene Mutation Database (HGMD)
ACOT4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT4 Gene

Disorders for ACOT4 Gene

Relevant External Links for ACOT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT4

No disorders were found for ACOT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOT4 Gene

Publications for ACOT4 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4 64
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3 64
  3. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. (PMID: 16141203) Westin M.A. … Alexson S.E. (J. Biol. Chem. 2005) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ACOT4 Gene

Sources for ACOT4 Gene

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