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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACOT4 Gene

protein-coding GIFtS: 52
GCID: GC14P074058

acyl-CoA thioesterase 4

Explore 2 diseases affiliated with
ACOT4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acyl-CoA Thioesterase 4¹ ² ³		EC 3.1.2.2³ ⁸
PTE-Ib¹ ² ³		FLJ31235¹
PTE2B¹ ² ³		PTE1B²
Peroxisomal Acyl Coenzyme A Thioester Hydrolase Ib² ³		Acyl-Coenzyme A Thioesterase 4²
Peroxisomal Long-Chain Acyl-CoA Thioesterase Ib² ³		Peroxisomal Acyl-CoA Thioesterase 2B²
PTE-2b² ³		PTEIB³

External Ids:	HGNC: 19748¹	Entrez Gene: 122970²	Ensembl: ENSG00000177465⁷	OMIM: 614314⁵	UniProtKB: Q8N9L9³

Export aliases for ACOT4 gene to outside databases

Previous GC identifers: GC14P073129 GC14P054227

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ACOT4_HUMAN, Q8N9L9

Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty

acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids

and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated

monocarboxylic acyl-CoAs

Gene Wiki entry for ACOT4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACOT4 gene promoter:
AREB6 PPAR-alpha Pax-3 AML1a Pax-5 ARP-1 Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACOT4 promoter sequence

Search SABiosciences Chromatin IP Primers for ACOT4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACOT4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.1

ACOT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT4 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P074058: view genomic region (about GC identifiers)

Start:	74,058,410 bp from pter	End:	74,063,200 bp from pter
Size:	4,791 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACOT4_HUMAN, Q8N9L9 (See protein sequence)

Recommended Name: Acyl-coenzyme A thioesterase 4

Size: 421 amino acids; 46327 Da

Subcellular location: Peroxisome

Miscellaneous: Human ACOT4 may have acquired the combined activities of mouse ACOT3, ACOT4, and ACOT5

1 PDB 3D structure from and Proteopedia for ACOT4:

3K2I (3D)

Secondary accessions: Q17RF4 Q5BKT6 Q86TX0 Q86TX1 Q96N88

Explore the universe of human proteins at neXtProt for ACOT4: NX_Q8N9L9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N9L9

4/6 DME Specific Peptides for ACOT4 (Q8N9L9) (see all 6)

IEPPYFP

PALGGSF

VELEVLDGH

LRDEKGALFRA

ACOT4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689544.3

ENSEMBL proteins:

ENSP00000323071

Human Recombinant Protein Products for ACOT4:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACOT4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005777	peroxisome	IDA	16940157

ACOT4 for ontologies About GeneDecksing

ACOT4 Antibody Products:

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	Uscn ELISAs and CLIAs for ACOT4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACOT4 for domains About GeneDecksing

3 InterPro domains/families:

IPR006862 Thio_Ohase/aa_AcTrfase

IPR014940 BAAT_C

IPR016662 Acyl-CoA_thioEstase_long-chain

Graphical View of Domain Structure for InterPro Entry Q8N9L9

ProtoNet protein and cluster: Q8N9L9

1 Blocks protein family: IPB006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

UniProtKB/Swiss-Prot: ACOT4_HUMAN, Q8N9L9

Similarity: Belongs to the C/M/P thioester hydrolase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ACOT4_HUMAN, Q8N9L9

Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty

acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids

and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated

monocarboxylic acyl-CoAs

Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate

Biophysicochemical properties: Kinetic parameters: KM=14 uM for succinyl-CoA; KM=147 uM for glutaryl-CoA; KM=3.4 uM for

C14-acyl-CoA; Vmax=581 nmol/min/mg enzyme toward succinyl-CoA; Vmax=132 nmol/min/mg enzyme toward glutaryl-CoA;

Vmax=137 nmol/min/mg enzyme toward C14-acyl-CoA;

Enzyme Number (IUBMB): EC 3.1.2.2¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004091	carboxylesterase activity	IEA	--
GO:0004778	succinyl-CoA hydrolase activity	IDA	16141203
GO:0005102	receptor binding	IPI	--
GO:0016290	palmitoyl-CoA hydrolase activity	IEA	--
GO:0047617	acyl-CoA hydrolase activity	IDA	16940157

ACOT4 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACOT4

miRNA Products:		OriGene 3'-UTR Clone: ACOT4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACOT4
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACOT4 (see all 7) OriGene shRNA RFP: ACOT4 OriGene siRNA: ACOT4
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ACOT4
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACOT4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACOT4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ACOT4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Biosynthesis of unsaturated fatty acids

Biosynthesis of unsaturated fatty acids

1.00

oleate biosynthesis II (animals)

0.32

fatty acid alpha-oxidation II

stearate biosynthesis I (animals)

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for ACOT4

	stearate biosynthesis I (animals)
	oleate biosynthesis II (animals)

1 Kegg Pathway (Kegg details for ACOT4):

Biosynthesis of unsaturated fatty acids

ACOT4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ACOT4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ACOT4 (ENSP00000323071⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FADS1	ENSP00000322229⁴	STRING: ENSP00000322229
SCD5	ENSP00000316329⁴	STRING: ENSP00000316329

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000038	very long-chain fatty acid metabolic process	IDA	16940157
GO:0001676	long-chain fatty acid metabolic process	IDA	16940157
GO:0006104	succinyl-CoA metabolic process	IDA	16940157
GO:0006637	acyl-CoA metabolic process	IDA	16940157
GO:0019605	NOT butyrate metabolic process	IDA	16940157

ACOT4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACOT4

10/66 HMDB Compounds for ACOT4 (see all 66) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
11'-Carboxy-alpha-chromanol	2,5,7,8-Tetramethyl-2-(4',8'-dimethyl-11'-carboxy-undecyl)-6-chromanol;RRR-11'-carboxy-alpha-chromanol;2-(11-carboxy-4,8-dimethylundecyl)-6-hydroxy-2,5,7,8-tetramethylchroman;11'-carboxy-alpha-tocopherol	--	--
11'-Carboxy-alpha-tocotrienol	alpha-CDMD(en)(2)HC;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,5,7,8-tetramethylchroman;alpha-CDMD(en)(,2)HC	--	--
11'-Carboxy-gama-chromanol	2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-chromanol;2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-hydroxychroman;RRR-11'-carboxy-gama-chromanol;11'-Carboxy-gama-tocopherol	--	--
11'-carboxy-gama-tocotrienol	gama-CDMD(en)(2)HC;carboxydimethyldecadienyl hydroxychroman;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,7,8-trimethylchroman	--	--
13'-carboxy-alpha-tocotrienol	13AaTE	--	--

Search CenterWatch for drugs/clinical trials and news about ACOT4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACOT4 gene:

NM_152331.3

Unigene Cluster for ACOT4:

Acyl-CoA thioesterase 4

Hs.49433 [show with all ESTs]

Unigene Representative Sequence: AK055797

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000326303(uc001xoo.3)

miRNA Products:		OriGene 3'-UTR Clone: ACOT4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACOT4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ACOT4
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACOT4 (see all 7) OriGene shRNA RFP: ACOT4 OriGene siRNA: ACOT4
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACOT4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACOT4

Additional cDNA sequence:

AK055797.1 AK094223.1 BC031799.1 BC090945.1 BC117341.1 BC117343.1 BX248023.1 BX248047.1

2 DOTS entries:

DT.100030638 DT.443254

24/35 AceView cDNA sequences (see all 35):

BX248047 BX248023 BM712466 BM675989 BX353531 AK094223 AA046424 AI126271

BE892339 BX357727 AA947131 BG285738 AA056177 BG741318 BC031799 AI830209

NM_152331 BI762267 BX095309 AK055797 CA421441 AA302899 AA661502 AA302895

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACOT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTGTCAT

About this image

ACOT4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

See ACOT4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACOT4

SOURCE GeneReport for Unigene cluster: Hs.49433

UniProtKB/Swiss-Prot: ACOT4_HUMAN, Q8N9L9

Tissue specificity: Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle

SABiosciences Custom PCR Arrays for ACOT4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACOT4

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ACOT4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ACOT4 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- -- (see all 3)	Uncharacterized protein (see all 3)	61(a) 58(a) (see all 3)	possible ortholog possible ortholog (see all 3)	5(28349920-28353884) 5(27308145-27311728)
lizard (Anolis carolinensis)	Reptilia	--	--	56(a)	possible ortholog	1(39211695-39218982)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-11e23.4¹	si:dkey-11e23.4	53.07(n) 45.77(a)		553440 XM_691619.3 XP_696711.2
worm (Caenorhabditis elegans)	Secernentea	C31H5.6¹	Protein C31H5.6	43.2(n) 31.73(a)		172725 NM_060030.3 NP_492431.2

ENSEMBL Gene Tree for ACOT4 (if available)
TreeFam Gene Tree for ACOT4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ACOT4 gene

ACOT6² ACOT2² ACOT1² BAAT²

4 SIMAP similar genes for ACOT4 using alignment to 1 protein entry: ACOT4_HUMAN:

ACOT2 ACOT1 ACOT6 BAAT

ACOT4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ACOT4
PGOHUM00000234674

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115826089^1,2	F	--	74056430(+)	`TTGGTC/GTCACT`	1	--	us2k¹		1		WA	118
rs139772387^1,2		--	74056464(+)	`CCCTCC/GCGGAG`	1	--	us2k¹		0	--	--	--	--
rs149387974^1,2		--	74056469(+)	`GCGGAG/TATGTT`	1	--	us2k¹		0	--	--	--	--
rs75166825^1,2	F	--	74056525(+)	`TCCCAT/CGTGCT`	1	--	us2k¹		1		WA	118
rs7140298^1,2	C,F,A,H	--	74056564(+)	`GGTCTT/CGCTGG`	1	--	us2k¹		8		NA CSA EA	257
rs12588433^1,2	C,F,A,H	--	74056575(+)	`ctcagA/Gagtga`	1	--	us2k¹		4		NA EA	132
rs118131041^1,2	F	--	74056600(+)	`GCGGTG/AAGTGT`	1	--	us2k¹		1		NA	120
rs7160971^1,2	C,F,A,H	--	74056604(+)	`TGAGTG/ATTACA`	1	--	us2k¹		10		NA WA CSA EA	377
rs146290260^1,2		--	74056620(+)	`TAAGGC/TGGCAT`	1	--	us2k¹		0	--	--	--	--
rs139518531^1,2		--	74056628(+)	`CATGTC/TTGGAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ACOT4 (74058410 - 74063200 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ACOT4
3 CNVs: 87268 76674 3942

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ACOT4 for disorders           About GeneDecksing

OMIM gene information: 614314    OMIM disorders: --

2 diseases for ACOT4:    About MalaCards

early-onset familial alzheimer disease alzheimer's disease

Export disorders for ACOT4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ACOT4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACOT4)

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Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PubMed id 16940157)^{1, 2, 3} Hunt M.C....Alexson S.E. (2006)
A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)^{1, 3} Hunt M.C....Alexson S.E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. (PubMed id 16141203)^{1, 9} Westin M.A....Alexson S.E. (2005)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PubMed id 10944470)¹ Jones J.M. and Gould S.J. (2000)
Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. (PubMed id 10567408)¹ Hunt M.C....Alexson S.E. (1999)
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)¹ Sherrington R....Holman K. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 122970	HGNC: 19748	AceView: PTE2B	Ensembl:ENSG00000177465	euGenes: HUgn122970
ECgene: ACOT4	Kegg: 122970	H-InvDB: ACOT4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ACOT4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACOT4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACOT4 gene:
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GeneCards and IP:
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acyl-CoA thioesterase 4

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acyl-CoA thioesterase 4

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