Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACOT4 Gene

Aliases for ACOT4 Gene

  • Acyl-CoA Thioesterase 4 2 3 4 5
  • Peroxisomal Acyl Coenzyme A Thioester Hydrolase Ib 3 4
  • Peroxisomal Long-Chain Acyl-CoA Thioesterase Ib 3 4
  • EC 3.1.2.2 4 63
  • PTE-2b 3 4
  • PTE-Ib 3 4
  • PTE2B 3 4
  • Peroxisomal Acyl-CoA Thioesterase 2B 3
  • PTE1B 3
  • PTEIB 4

External Ids for ACOT4 Gene

Previous GeneCards Identifiers for ACOT4 Gene

  • GC14P073129
  • GC14P074058
  • GC14P054227

Summaries for ACOT4 Gene

GeneCards Summary for ACOT4 Gene

ACOT4 (Acyl-CoA Thioesterase 4) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT2.

UniProtKB/Swiss-Prot for ACOT4 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.

Gene Wiki entry for ACOT4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT4 Gene

Genomics for ACOT4 Gene

Regulatory Elements for ACOT4 Gene

Enhancers for ACOT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACOT4 on UCSC Golden Path with GeneCards custom track

Promoters for ACOT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACOT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOT4 Gene

Chromosome:
14
Start:
73,591,706 bp from pter
End:
73,596,496 bp from pter
Size:
4,791 bases
Orientation:
Plus strand

Genomic View for ACOT4 Gene

Genes around ACOT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT4 Gene

Proteins for ACOT4 Gene

  • Protein details for ACOT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9L9-ACOT4_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 4
    Protein Accession:
    Q8N9L9
    Secondary Accessions:
    • Q17RF4
    • Q5BKT6
    • Q86TX0
    • Q86TX1
    • Q96N88

    Protein attributes for ACOT4 Gene

    Size:
    421 amino acids
    Molecular mass:
    46327 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Human ACOT4 may have acquired the combined activities of mouse ACOT3, ACOT4, and ACOT5.

    Three dimensional structures from OCA and Proteopedia for ACOT4 Gene

neXtProt entry for ACOT4 Gene

Proteomics data for ACOT4 Gene at MOPED

Selected DME Specific Peptides for ACOT4 Gene

Post-translational modifications for ACOT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACOT4 Gene

Gene Families for ACOT4 Gene

Suggested Antigen Peptide Sequences for ACOT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9L9

UniProtKB/Swiss-Prot:

ACOT4_HUMAN :
  • Belongs to the C/M/P thioester hydrolase family.
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT4: view

Function for ACOT4 Gene

Molecular function for ACOT4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=14 uM for succinyl-CoA {ECO:0000269 PubMed:16940157}; KM=147 uM for glutaryl-CoA {ECO:0000269 PubMed:16940157}; KM=3.4 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=581 nmol/min/mg enzyme toward succinyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=132 nmol/min/mg enzyme toward glutaryl-CoA {ECO:0000269 PubMed:16940157}; Vmax=137 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate.
UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.

Enzyme Numbers (IUBMB) for ACOT4 Gene

Gene Ontology (GO) - Molecular Function for ACOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016790 thiolester hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT4: view
genes like me logo Genes that share phenotypes with ACOT4: view

Animal Model Products

miRNA for ACOT4 Gene

miRTarBase miRNAs that target ACOT4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOT4 Gene

Localization for ACOT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT4 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT4 Gene COMPARTMENTS Subcellular localization image for ACOT4 gene
Compartment Confidence
peroxisome 5
cytosol 2
cytoskeleton 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ACOT4 Gene

Pathways & Interactions for ACOT4 Gene

genes like me logo Genes that share pathways with ACOT4: view

Interacting Proteins for ACOT4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323071%0d%0a9606.ENSP00000215567%0d%0a9606.ENSP00000407401%0d%0a
Selected Interacting proteins: ENSP00000323071 for ACOT4 Gene via STRING

Gene Ontology (GO) - Biological Process for ACOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process IEA,IDA 16940157
GO:0019605 NOT butyrate metabolic process IDA 16940157
GO:0032789 unsaturated monocarboxylic acid metabolic process IDA 16940157
genes like me logo Genes that share ontologies with ACOT4: view

No data available for SIGNOR curated interactions for ACOT4 Gene

Drugs & Compounds for ACOT4 Gene

(11) Drugs for ACOT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Gamma-Homolinolenic acid Approved Nutra 0
Icosapent Approved Nutra 0
oleic acid Experimental Pharma Full agonist, Agonist 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(43) Additional Compounds for ACOT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT4: view

Transcripts for ACOT4 Gene

mRNA/cDNA for ACOT4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT4 Gene

Acyl-CoA thioesterase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT4 Gene

No ASD Table

Relevant External Links for ACOT4 Gene

GeneLoc Exon Structure for
ACOT4
ECgene alternative splicing isoforms for
ACOT4

Expression for ACOT4 Gene

mRNA expression in normal human tissues for ACOT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOT4 Gene

This gene is overexpressed in Liver (x8.4) and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for ACOT4 Gene

This gene is overexpressed in Heart (39.0), Placenta (11.0), and Testis (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACOT4 Gene



SOURCE GeneReport for Unigene cluster for ACOT4 Gene Hs.49433

mRNA Expression by UniProt/SwissProt for ACOT4 Gene

Q8N9L9-ACOT4_HUMAN
Tissue specificity: Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle.
genes like me logo Genes that share expression patterns with ACOT4: view

Protein tissue co-expression partners for ACOT4 Gene

Primer Products

Orthologs for ACOT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACOT4 35
  • 86.27 (n)
  • 82.89 (a)
-- 36
  • 82 (a)
OneToMany
MGC160092 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ACOT4 35
  • 87.11 (n)
  • 83.29 (a)
ACOT4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acot4 35
  • 81.31 (n)
  • 74.35 (a)
Acot4 16
Acot4 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACOT4 35
  • 99.6 (n)
  • 99.76 (a)
ACOT4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acot4 35
  • 82.03 (n)
  • 77.2 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-11e23.4 36
  • 42 (a)
ManyToMany
si:dkey-183c16.7 36
  • 30 (a)
ManyToMany
si:dkeyp-89c11.1 36
  • 29 (a)
ManyToMany
si:dkeyp-89c11.3 36
  • 30 (a)
ManyToMany
zgc:101553 36
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C31H5.6 36
  • 26 (a)
ManyToMany
K05B2.4 36
  • 27 (a)
ManyToMany
T05E7.1 36
  • 23 (a)
ManyToMany
W03D8.8 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for ACOT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT4 Gene

ENSEMBL:
Gene Tree for ACOT4 (if available)
TreeFam:
Gene Tree for ACOT4 (if available)

Paralogs for ACOT4 Gene

Paralogs for ACOT4 Gene

(4) SIMAP similar genes for ACOT4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ACOT4 Gene

genes like me logo Genes that share paralogs with ACOT4: view

Variants for ACOT4 Gene

Sequence variations from dbSNP and Humsavar for ACOT4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3742819 - 73,592,128(-) GCCGC(A/G)GGCGT reference, missense
rs35724886 - 73,593,804(+) GTTGG(A/C)TCTAG reference, missense
rs7140298 -- 73,589,860(+) GGTCT(C/T)GCTGG upstream-variant-2KB
rs7140346 -- 73,589,944(+) CCTCC(C/T)GGTGA upstream-variant-2KB
rs4044909 -- 73,594,436(+) TCTGT(-/GGCTCAGC)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT4 Gene

Variant ID Type Subtype PubMed ID
dgv1958n71 CNV Gain 21882294
dgv641e1 CNV Complex 17122850
nsv428295 CNV Gain 18775914
nsv832828 CNV Gain+Loss 17160897

Variation tolerance for ACOT4 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.67; 89.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT4 Gene

Human Gene Mutation Database (HGMD)
ACOT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT4 Gene

Disorders for ACOT4 Gene

Relevant External Links for ACOT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT4

No disorders were found for ACOT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOT4 Gene

Publications for ACOT4 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4 67
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3
  3. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. (PMID: 16141203) Westin M.A. … Alexson S.E. (J. Biol. Chem. 2005) 3 23
  4. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. (PMID: 25961151) Auer P.L. … Rich S.S. (JAMA Neurol 2015) 3
  5. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)- Pex5p affinities. (PMID: 20178365) Ghosh D. … Berg J.M. (J. Am. Chem. Soc. 2010) 3

Products for ACOT4 Gene

Sources for ACOT4 Gene

Content