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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACOT2 Gene

protein-coding   GIFtS: 60
GCID: GC14P074036

Acyl-CoA Thioesterase 2

Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acyl-CoA Thioesterase 21 2 3     EC 3.1.2.23 8
PTE22 3 5     MTE12 5
Mitochondrial Acyl-CoA Thioesterase 11 2     CTE-IA2
Acyl-Coenzyme A Thioester Hydrolase 2a2 3     CTE1A2
Long-Chain Acyl-CoA Thioesterase 22 3     Acyl-Coenzyme A Thioesterase 2, Mitochondrial2
PTE2A2 3     Peroxisomal Long-Chain Acyl-CoA Thioesterase 22
ZAP1282 3     CTE-Ia3

External Ids:    HGNC: 184311   Entrez Gene: 109652   Ensembl: ENSG000001196737   OMIM: 6099725   UniProtKB: P497533   

Export aliases for ACOT2 gene to outside databases

Previous GC identifers: GC14P073106 GC14P054203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACOT2 Gene:
This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase
genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jan 2012)

GeneCards Summary for ACOT2 Gene: 
ACOT2 (acyl-CoA thioesterase 2) is a protein-coding gene. Diseases associated with ACOT2 include alzheimer's disease, and among its related super-pathways are Fatty acid elongation and fatty acid activation. GO annotations related to this gene include palmitoyl-CoA hydrolase activity and receptor binding. An important paralog of this gene is ACOT6.

UniProtKB/Swiss-Prot: ACOT2_HUMAN, P49753
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs

Gene Wiki entry for ACOT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACOT2 gene promoter:
         GR   STAT5B   AML1a   Pax-5   FOXD1   Arnt   AREB6   HFH-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACOT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACOT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

ACOT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P074036:  view genomic region     (about GC identifiers)

Start:
74,034,324 bp from pter      End:
74,042,359 bp from pter
Size:
8,036 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACOT2_HUMAN, P49753 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 2, mitochondrial precursor  
Size: 483 amino acids; 53218 Da
Subcellular location: Mitochondrion
Caution: Was originally (PubMed:10944470) thought to be peroxisomal but was later shown (PubMed:16940157) to be
mitochondrial
Sequence caution: Sequence=AAC42007.1; Type=Frameshift; Positions=215, 226;
1 PDB 3D structure from and Proteopedia for ACOT2:
3HLK (3D)    
Secondary accessions: Q3I5F8 Q53EK4 Q9NUX4
Alternative splicing: 2 isoforms:  P49753-1   P49753-2   

Explore the universe of human proteins at neXtProt for ACOT2: NX_P49753

Explore proteomics data for ACOT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49753

  • 4/10 DME Specific Peptides for ACOT2 (P49753) (see all 10)
     DDHNWKS  WKSEFYA  IEPPYFP  PALGGSF 

    ACOT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACOT2 Protein Expression
    REFSEQ proteins: NP_006812.3  
    ENSEMBL proteins: 
     ENSP00000440961   ENSP00000238651  

    Human Recombinant Protein Products for ACOT2: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    ACOT2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ACOT: Acyl CoA thioesterases

    3 InterPro protein domains:
     IPR006862 Thio_Ohase/aa_AcTrfase
     IPR014940 BAAT_C
     IPR016662 Acyl-CoA_thioEstase_long-chain

    Graphical View of Domain Structure for InterPro Entry P49753

    ProtoNet protein and cluster: P49753

    1 Blocks protein domain: IPB006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

    UniProtKB/Swiss-Prot: ACOT2_HUMAN, P49753
    Similarity: Belongs to the C/M/P thioester hydrolase family


    ACOT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACOT2_HUMAN, P49753
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
    fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
    fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs
    Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate
    Biophysicochemical properties: Kinetic parameters: KM=40.3 uM for C10-acyl-CoA; KM=8.9 uM for C12-acyl-CoA; KM=1.6
    uM for C14-acyl-CoA; KM=2.0 uM for C16-acyl-CoA; KM=2.8 uM for C18-acyl-CoA; KM=4.8 uM for C20-acyl-CoA; KM=4.5
    uM for C16:1-acyl-CoA; KM=6.1 uM for C18:1-acyl-CoA; KM=4.3 uM for C18:1-trans-acyl-CoA; Vmax=212 nmol/min/mg
    enzyme toward C10-acyl-CoA; Vmax=681 nmol/min/mg enzyme toward C12-acyl-CoA; Vmax=766 nmol/min/mg enzyme toward
    C14-acyl-CoA; Vmax=656 nmol/min/mg enzyme toward C16-acyl-CoA; Vmax=488 nmol/min/mg enzyme toward C18-acyl-CoA;
    Vmax=408 nmol/min/mg enzyme toward C20-acyl-CoA; Vmax=661 nmol/min/mg enzyme toward C16:1-acyl-CoA; Vmax=304
    nmol/min/mg enzyme toward C18:1-acyl-CoA; Vmax=418 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA;

         Enzyme Number (IUBMB): EC 3.1.2.21 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091carboxylesterase activity IEA--
    GO:0005102receptor binding IPI--
    GO:0016290palmitoyl-CoA hydrolase activity IEA--
    GO:0016790thiolester hydrolase activity ----
    GO:0047617acyl-CoA hydrolase activity IDA10944470
         
    ACOT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACOT2:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACOT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    oleate biosynthesis II (animals)0.32
    Fatty acid elongation0.38
    2fatty acid activation
    stearate biosynthesis I (animals)0.55
    3palmitate biosynthesis I (animals)
    palmitate biosynthesis I (animals)0.43
    4Metabolism
    Metabolic pathways0.40
    5Ovarian steroidogenesis
    Ovarian steroidogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ACOT2
        stearate biosynthesis I (animals)
    oleate biosynthesis II (animals)
    palmitate biosynthesis I (animals)


    4         Kegg Pathways  (Kegg details for ACOT2):
        Fatty acid elongation
    Biosynthesis of unsaturated fatty acids
    Metabolic pathways
    Ovarian steroidogenesis


    ACOT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACOT2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ACOT2 (P497533 ENSP000002386514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF277Q9NRM23, ENSP000003545014I2D: score=2 STRING: ENSP00000354501
    NRBF2Q96F243I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process IDA16940157
    GO:0001676long-chain fatty acid metabolic process IDA16940157
    GO:0006637acyl-CoA metabolic process IDA10944470

    ACOT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACOT2

    10/68 HMDB Compounds for ACOT2 (see all 68)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    11'-Carboxy-alpha-chromanol2,5,7,8-Tetramethyl-2-(4',8'-dimethyl-11'-carboxy-undecyl)-6-chromanol;RRR-11'-carboxy-alpha-chromanol;2-(11-carboxy-4,8-dimethylundecyl)-6-hydroxy-2,5,7,8-tetramethylchroman;11'-carboxy-alpha-tocopherol ----
    11'-Carboxy-alpha-tocotrienolalpha-CDMD(en)(2)HC;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,5,7,8-tetramethylchroman;alpha-CDMD(en)(,2)HC ----
    11'-Carboxy-gama-chromanol2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-chromanol;2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-hydroxychroman;RRR-11'-carboxy-gama-chromanol;11'-Carboxy-gama-tocopherol ----
    11'-carboxy-gama-tocotrienolgama-CDMD(en)(2)HC;carboxydimethyldecadienyl hydroxychroman;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,7,8-trimethylchroman ----
    13'-carboxy-alpha-tocotrienol13AaTE ----

    Search CenterWatch for drugs/clinical trials and news about ACOT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACOT2 gene: 
    NM_006821.5  

    Unigene Cluster for ACOT2:

    Acyl-CoA thioesterase 2
    Hs.446685  [show with all ESTs]
    Unigene Representative Sequence: NM_006821
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538782(uc001xom.3) ENST00000238651(uc001xon.4) ENST00000557857


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    Additional mRNA sequence: 

    AK001939.1 AK093131.1 AK223635.1 AY005822.1 BC004436.1 BC006335.2 BC006500.2 BC144425.1 
    DQ082755.1 L40401.1 NR_046028.1 

    8 DOTS entries:

    DT.445656  DT.95157623  DT.100824506  DT.100824503  DT.100824504  DT.99970598  DT.100824510  DT.100824511 

    24/403 AceView cDNA sequences (see all 403):

    CB998061 BM853353 BM982293 AA953357 CR599629 BM557385 AK093131 BI490071 
    BE409053 CA392013 BQ021741 BQ221601 BP340920 BQ777220 F25969 CR624943 
    F29758 BI821071 CR618088 CR622314 BQ051952 CB961857 AW058086 CB265651 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACOT2 expression in normal human tissues (normalized intensities)      ACOT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCTCTCT
    ACOT2 Expression
    About this image


    ACOT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Retina
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See ACOT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACOT2

    SOURCE GeneReport for Unigene cluster: Hs.446685

    UniProtKB/Swiss-Prot: ACOT2_HUMAN, P49753
    Tissue specificity: Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACOT2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot21 , 5 acyl-CoA thioesterase 21, 5 79.66(n)1
    75.72(a)1
      12 (38.99 cM)5
    1712101  NM_134188.31  NP_598949.31 
     839878615 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    62(a)
    50(a)
    1 ↔ many
    possible ortholog
    5(25464271-25468294)
    5(24431806-24434906)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    1 → many
    1(39211695-39218982)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.122472 Transcribed sequence with weak similarity to protein more 69.66(n)    BX708583.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-11e23.46
    si:dkey-288i20.16
    (see all 9)
    si:dkey-288i20.1
    (see all 9)
    43(a)
    43(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    20(28961321-28964638)
    16(3418191-3422128)
    worm
    (Caenorhabditis elegans)
    Secernentea K05B2.46
    W03D8.86
    (see all 4)
    Protein W03D8.8
    (see all 4)
    26(a)
    25(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(4919020-4920988)
    I(2791689-2794895)


    ENSEMBL Gene Tree for ACOT2 (if available)
    TreeFam Gene Tree for ACOT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACOT2 gene
    ACOT62  ACOT42  ACOT12  BAAT2  
    4 SIMAP similar genes for ACOT2 using alignment to 2 protein entries:     ACOT2_HUMAN (see all proteins):
    ACOT1    ACOT4    ACOT6    BAAT

    ACOT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/317 SNPs in ACOT2 are shown (see all 317)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71427981,2
    C,H--74032326(+) ggttcG/Atggtc 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1159455101,2
    F--74032355(+) AGCTGC/TGGACC 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1381909521,2
    C--74032389(+) TAAGGC/TGGCGT 1 -- us2k10--------
    rs1162388311,2
    F--74032408(+) TTGTTC/TGTTTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1437593991,2
    --74032435(+) GTCTCA/GCTGGC 1 -- us2k10--------
    rs1153039611,2
    F--74032477(+) AGTGTT/CAGAGC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1471918981,2
    --74032499(+) GTGTGA/GACGCA 1 -- us2k10--------
    rs1395743441,2
    --74032576(+) GGACCC/GCAGCG 1 -- us2k10--------
    rs1497862311,2
    C--74032649(+) GCTGAC/TTGGTA 1 -- us2k10--------
    rs1447453191,2
    C--74032730(+) CTCCAC/TGTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACOT2 (74034324 - 74042359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for ACOT2 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821106CNV Deletion20802225
    esv2672436CNV Deletion23128226
    esv2748867CNV Deletion23290073
    nsv436178CNV Deletion17901297
    esv1006342CNV Deletion20482838
    nsv826985CNV Loss20364138
    esv29945CNV Loss18421352
    nsv510643CNV Loss20534489
    nsv1350CNV Loss18451855
    nsv826987CNV Loss20364138

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609972    OMIM disorders: --

    2 diseases for ACOT2:    About MalaCards
    alzheimer's disease    


    ACOT2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ACOT2
    Human Genome Epidemiology (HuGE) Navigator: ACOT2 (2 documents)

    Export disorders for ACOT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACOT2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ACOT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PubMed id 16940157)1, 2, 3 Hunt M.C....Alexson S.E. (2006)
    2. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PubMed id 10944470)1, 2, 9 Jones J.M. and Gould S.J. (2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2 Sherrington R....Holman K. (1995)
    9. Crystal structure of human mitochondrial acyl-CoA thi oesterase (ACOT2). (PubMed id 19497300)1, 9 Mandel C.R....Tong L. (2009)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10965 HGNC: 18431 AceView: ZAP128 Ensembl:ENSG00000119673 euGenes: HUgn10965
    ECgene: ACOT2 Kegg: 10965 H-InvDB: ACOT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACOT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACOT2 gene:
    Search GeneIP for patents involving ACOT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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