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Aliases for ACOT2 Gene

Aliases for ACOT2 Gene

  • Acyl-CoA Thioesterase 2 2 3 4 5
  • Acyl-Coenzyme A Thioester Hydrolase 2a 3 4
  • Mitochondrial Acyl-CoA Thioesterase 1 2 3
  • Long-Chain Acyl-CoA Thioesterase 2 3 4
  • EC 3.1.2.2 4 61
  • CTE-IA 3 4
  • ZAP128 3 4
  • PTE2A 3 4
  • PTE2 3 4
  • Peroxisomal Long-Chain Acyl-CoA Thioesterase 2 3
  • Acyl-Coenzyme A Thioesterase 2, Mitochondrial 3
  • CTE1A 3
  • MTE1 3

External Ids for ACOT2 Gene

Previous GeneCards Identifiers for ACOT2 Gene

  • GC14P073106
  • GC14P074036
  • GC14P054203

Summaries for ACOT2 Gene

Entrez Gene Summary for ACOT2 Gene

  • This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for ACOT2 Gene

ACOT2 (Acyl-CoA Thioesterase 2) is a Protein Coding gene. Diseases associated with ACOT2 include Early-Onset Familial Alzheimer Disease. Among its related pathways are palmitate biosynthesis and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT1.

UniProtKB/Swiss-Prot for ACOT2 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.

Gene Wiki entry for ACOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT2 Gene

Genomics for ACOT2 Gene

Regulatory Elements for ACOT2 Gene

Enhancers for ACOT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ACOT2 on UCSC Golden Path with GeneCards custom track

Promoters for ACOT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACOT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOT2 Gene

Chromosome:
14
Start:
73,567,620 bp from pter
End:
73,575,658 bp from pter
Size:
8,039 bases
Orientation:
Plus strand

Genomic View for ACOT2 Gene

Genes around ACOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT2 Gene

Proteins for ACOT2 Gene

  • Protein details for ACOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49753-ACOT2_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 2, mitochondrial
    Protein Accession:
    P49753
    Secondary Accessions:
    • Q3I5F8
    • Q53EK4
    • Q9NUX4

    Protein attributes for ACOT2 Gene

    Size:
    483 amino acids
    Molecular mass:
    53218 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC42007.1; Type=Frameshift; Positions=215, 226; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACOT2 Gene

    Alternative splice isoforms for ACOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOT2 Gene

Post-translational modifications for ACOT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT2 Gene

Domains & Families for ACOT2 Gene

Gene Families for ACOT2 Gene

Suggested Antigen Peptide Sequences for ACOT2 Gene

Graphical View of Domain Structure for InterPro Entry

P49753

UniProtKB/Swiss-Prot:

ACOT2_HUMAN :
  • Belongs to the C/M/P thioester hydrolase family.
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT2: view

Function for ACOT2 Gene

Molecular function for ACOT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=40.3 uM for C10-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=8.9 uM for C12-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=1.6 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.0 uM for C16-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.8 uM for C18-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.8 uM for C20-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.5 uM for C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=6.1 uM for C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.3 uM for C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=212 nmol/min/mg enzyme toward C10-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=681 nmol/min/mg enzyme toward C12-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=766 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=656 nmol/min/mg enzyme toward C16-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=488 nmol/min/mg enzyme toward C18-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=408 nmol/min/mg enzyme toward C20-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=661 nmol/min/mg enzyme toward C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=304 nmol/min/mg enzyme toward C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=418 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate.
UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.

Enzyme Numbers (IUBMB) for ACOT2 Gene

Gene Ontology (GO) - Molecular Function for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT2: view
genes like me logo Genes that share phenotypes with ACOT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOT2 Gene

Localization for ACOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT2 Gene COMPARTMENTS Subcellular localization image for ACOT2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
peroxisome 3
cytosol 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 16940157
GO:0005759 mitochondrial matrix TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ACOT2: view

Pathways & Interactions for ACOT2 Gene

genes like me logo Genes that share pathways with ACOT2: view

Interacting Proteins for ACOT2 Gene

Gene Ontology (GO) - Biological Process for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process IDA 10944470
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with ACOT2: view

No data available for SIGNOR curated interactions for ACOT2 Gene

Drugs & Compounds for ACOT2 Gene

(12) Drugs for ACOT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Gamma-Homolinolenic acid Approved Nutra 0
Icosapent Approved Nutra Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 0

(43) Additional Compounds for ACOT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT2: view

Transcripts for ACOT2 Gene

Unigene Clusters for ACOT2 Gene

Acyl-CoA thioesterase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT2 Gene

No ASD Table

Relevant External Links for ACOT2 Gene

GeneLoc Exon Structure for
ACOT2
ECgene alternative splicing isoforms for
ACOT2

Expression for ACOT2 Gene

mRNA expression in normal human tissues for ACOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACOT2 Gene

This gene is overexpressed in Kidney (10.8), Prostate (8.5), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACOT2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ACOT2 Gene:

ACOT2

SOURCE GeneReport for Unigene cluster for ACOT2 Gene:

Hs.446685

mRNA Expression by UniProt/SwissProt for ACOT2 Gene:

P49753-ACOT2_HUMAN
Tissue specificity: Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.
genes like me logo Genes that share expression patterns with ACOT2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ACOT2 Gene

Orthologs for ACOT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACOT2 34
  • 85.67 (n)
  • 81.24 (a)
ACOT2 35
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ACOT2 34
  • 84.76 (n)
  • 81.08 (a)
-- 35
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Acot2 34
  • 79.81 (n)
  • 75.72 (a)
Acot2 16
Acot1 35
  • 77 (a)
ManyToMany
Acot2 35
  • 75 (a)
ManyToMany
Acot3 35
  • 75 (a)
ManyToMany
Acot5 35
  • 74 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ACOT2 34
  • 98.62 (n)
  • 98.55 (a)
rat
(Rattus norvegicus)
Mammalia Acot2 34
  • 79.48 (n)
  • 75.11 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC771753 34
  • 67.32 (n)
  • 64.77 (a)
-- 35
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia acot2 34
  • 60.69 (n)
  • 59.33 (a)
Str.12247 34
zebrafish
(Danio rerio)
Actinopterygii zgc:77651 35
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C31H5.6 35
  • 25 (a)
ManyToMany
K05B2.4 35
  • 28 (a)
ManyToMany
T05E7.1 35
  • 22 (a)
ManyToMany
W03D8.8 35
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for ACOT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOT2 Gene

ENSEMBL:
Gene Tree for ACOT2 (if available)
TreeFam:
Gene Tree for ACOT2 (if available)

Paralogs for ACOT2 Gene

Paralogs for ACOT2 Gene

(4) SIMAP similar genes for ACOT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOT2: view

Variants for ACOT2 Gene

Sequence variations from dbSNP and Humsavar for ACOT2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7494 - 73,575,485(+) TGGCC(A/G)CGAGG nc-transcript-variant, reference, missense
rs11545741 - 73,569,288(+) CTCAG(A/G/T)TCTGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs14290 -- 73,575,613(+) AATAA(C/T)TAAAG nc-transcript-variant, utr-variant-3-prime
rs7142798 -- 73,565,622(+) ggttc(A/G)tggtc upstream-variant-2KB
rs7143834 -- 73,572,642(+) GCAtt(C/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT2 Gene

Variant ID Type Subtype PubMed ID
dgv1935n100 CNV gain 25217958
dgv3764n54 CNV gain 21841781
dgv3774n54 CNV loss 21841781
dgv408e214 CNV gain 21293372
dgv656e212 CNV gain 25503493
dgv662e212 CNV loss 25503493
esv1006342 CNV deletion 20482838
esv2672436 CNV deletion 23128226
esv2748867 CNV deletion 23290073
esv2759996 CNV gain 17122850
esv2760335 CNV gain+loss 21179565
esv2761566 CNV gain+loss 21179565
esv29080 CNV gain+loss 19812545
esv29945 CNV loss 18421352
esv30006 CNV gain 17803354
esv33155 CNV gain+loss 17666407
esv3634913 CNV loss 21293372
esv3892561 CNV gain 25118596
esv3892562 CNV gain 25118596
nsv1035460 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv1350 CNV deletion 18451855
nsv428295 CNV gain 18775914
nsv436178 CNV deletion 17901297
nsv442346 CNV gain+loss 18776908
nsv510643 CNV deletion 20534489
nsv514751 CNV gain 21397061
nsv565162 CNV loss 21841781
nsv565172 CNV loss 21841781
nsv819954 CNV gain 19587683
nsv821106 CNV deletion 20802225
nsv826976 CNV loss 20364138
nsv826985 CNV loss 20364138
nsv826987 CNV loss 20364138
nsv826988 CNV loss 20364138
nsv832828 CNV gain+loss 17160897
nsv9153 CNV gain+loss 18304495

Variation tolerance for ACOT2 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT2 Gene

Disorders for ACOT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACOT2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
early-onset familial alzheimer disease
  • eofad
- elite association - COSMIC cancer census association via MalaCards
Search ACOT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACOT2

Genetic Association Database (GAD)
ACOT2
Human Genome Epidemiology (HuGE) Navigator
ACOT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT2
genes like me logo Genes that share disorders with ACOT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT2 Gene

Publications for ACOT2 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4 65
  2. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PMID: 10944470) Jones J.M. … Gould S.J. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  5. Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2). (PMID: 19497300) Mandel C.R. … Tong L. (Biochem. Biophys. Res. Commun. 2009) 3 22 65

Products for ACOT2 Gene

Sources for ACOT2 Gene

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