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Aliases for ACOT2 Gene

Aliases for ACOT2 Gene

  • Acyl-CoA Thioesterase 2 2 3 4
  • PTE2 3 4 6
  • Acyl-Coenzyme A Thioester Hydrolase 2a 3 4
  • Mitochondrial Acyl-CoA Thioesterase 1 2 3
  • Long-Chain Acyl-CoA Thioesterase 2 3 4
  • EC 4 64
  • CTE-IA 3 4
  • ZAP128 3 4
  • PTE2A 3 4
  • MTE1 3 6
  • Peroxisomal Long-Chain Acyl-CoA Thioesterase 2 3
  • Acyl-Coenzyme A Thioesterase 2, Mitochondrial 3
  • CTE1A 3

External Ids for ACOT2 Gene

Summaries for ACOT2 Gene

Entrez Gene Summary for ACOT2 Gene

  • This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for ACOT2 Gene

ACOT2 (Acyl-CoA Thioesterase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Ovarian steroidogenesis. GO annotations related to this gene include receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT4.

UniProtKB/Swiss-Prot for ACOT2 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.

Gene Wiki entry for ACOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT2 Gene

Genomics for ACOT2 Gene

Genomic Location for ACOT2 Gene

73,567,620 bp from pter
73,575,658 bp from pter
8,039 bases
Plus strand

Genomic View for ACOT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT2 Gene

Regulatory Elements for ACOT2 Gene

Proteins for ACOT2 Gene

  • Protein details for ACOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A thioesterase 2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q3I5F8
    • Q53EK4
    • Q9NUX4

    Protein attributes for ACOT2 Gene

    483 amino acids
    Molecular mass:
    53218 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC42007.1; Type=Frameshift; Positions=215, 226; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACOT2 Gene

    Alternative splice isoforms for ACOT2 Gene


neXtProt entry for ACOT2 Gene

Proteomics data for ACOT2 Gene at MOPED

Post-translational modifications for ACOT2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys348

Other Protein References for ACOT2 Gene

Domains for ACOT2 Gene

Gene Families for ACOT2 Gene

  • ACOT :Acyl CoA thioesterases


  • Belongs to the C/M/P thioester hydrolase family.:
    • P49753
genes like me logo Genes that share domains with ACOT2: view

Function for ACOT2 Gene

Molecular function for ACOT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=40.3 uM for C10-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=8.9 uM for C12-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=1.6 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.0 uM for C16-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.8 uM for C18-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.8 uM for C20-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.5 uM for C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=6.1 uM for C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.3 uM for C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=212 nmol/min/mg enzyme toward C10-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=681 nmol/min/mg enzyme toward C12-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=766 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=656 nmol/min/mg enzyme toward C16-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=488 nmol/min/mg enzyme toward C18-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=408 nmol/min/mg enzyme toward C20-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=661 nmol/min/mg enzyme toward C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=304 nmol/min/mg enzyme toward C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=418 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + H(2)O = CoA + palmitate
UniProtKB/Swiss-Prot Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.

Enzyme Numbers (IUBMB) for ACOT2 Gene

Gene Ontology (GO) - Molecular Function for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity --
GO:0047617 acyl-CoA hydrolase activity IDA 10944470
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT2: view

Phenotypes for ACOT2 Gene

GenomeRNAi human phenotypes for ACOT2:
genes like me logo Genes that share phenotypes with ACOT2: view

miRNA for ACOT2 Gene

miRTarBase miRNAs that target ACOT2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACOT2 Gene

Localization for ACOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT2 Gene


Subcellular locations from

Jensen Localization Image for ACOT2 Gene COMPARTMENTS Subcellular localization image for ACOT2 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 16940157
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ACOT2: view

Pathways for ACOT2 Gene

genes like me logo Genes that share pathways with ACOT2: view

Interacting Proteins for ACOT2 Gene

Gene Ontology (GO) - Biological Process for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process IDA 10944470
genes like me logo Genes that share ontologies with ACOT2: view

Compounds for ACOT2 Gene

(68) HMDB Compounds for ACOT2 Gene

Compound Synonyms Cas Number PubMed IDs
  • (E)-S-2-decenoate Coenzyme A
  • 2-trans-Dodecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
  • (2E)-Tetradecenoyl-Coenzyme A
genes like me logo Genes that share compounds with ACOT2: view

Transcripts for ACOT2 Gene

Unigene Clusters for ACOT2 Gene

Acyl-CoA thioesterase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT2 Gene

No ASD Table

Relevant External Links for ACOT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOT2 Gene

mRNA expression in normal human tissues for ACOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOT2 Gene

SOURCE GeneReport for Unigene cluster for ACOT2 Gene Hs.446685

mRNA Expression by UniProt/SwissProt for ACOT2 Gene

Tissue specificity: Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.
genes like me logo Genes that share expressions with ACOT2: view

Orthologs for ACOT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACOT2 36
  • 98.62 (n)
  • 98.55 (a)
(Bos Taurus)
Mammalia ACOT2 36
  • 85.67 (n)
  • 81.24 (a)
ACOT2 37
  • 78 (a)
(Canis familiaris)
Mammalia -- 37
  • 80 (a)
ACOT2 36
  • 84.76 (n)
  • 81.08 (a)
(Mus musculus)
Mammalia Acot1 37
  • 77 (a)
Acot2 36
  • 79.81 (n)
  • 75.72 (a)
Acot2 16
Acot2 37
  • 75 (a)
Acot3 37
  • 75 (a)
Acot5 37
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
-- 37
  • 66 (a)
(Rattus norvegicus)
Mammalia Acot2 36
  • 79.48 (n)
  • 75.11 (a)
(Gallus gallus)
Aves -- 37
  • 62 (a)
LOC771753 36
  • 67.32 (n)
  • 64.77 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acot2 36
  • 60.69 (n)
  • 59.33 (a)
Str.12247 36
(Danio rerio)
Actinopterygii zgc:77651 37
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C31H5.6 37
  • 25 (a)
K05B2.4 37
  • 28 (a)
T05E7.1 37
  • 22 (a)
W03D8.8 37
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
-- 37
  • 28 (a)
-- 37
  • 34 (a)
-- 37
  • 33 (a)
-- 37
  • 35 (a)
-- 37
  • 28 (a)
-- 37
  • 35 (a)
-- 37
  • 31 (a)
-- 37
  • 35 (a)
-- 37
  • 30 (a)
Species with no ortholog for ACOT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOT2 Gene

Gene Tree for ACOT2 (if available)
Gene Tree for ACOT2 (if available)

Paralogs for ACOT2 Gene

Paralogs for ACOT2 Gene

Selected SIMAP similar genes for ACOT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOT2: view

Variants for ACOT2 Gene

Sequence variations from dbSNP and Humsavar for ACOT2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7494 - 73,575,485(+) TGGCC(A/G)CGAGG reference, missense, nc-transcript-variant
rs14290 -- 73,575,613(+) AATAA(C/T)TAAAG utr-variant-3-prime, nc-transcript-variant
rs1049653 -- 73,575,606(+) TGTTT(A/T)TAATA utr-variant-3-prime, nc-transcript-variant
rs1049658 -- 73,575,612(+) TAATA(A/C)CTAAA utr-variant-3-prime, nc-transcript-variant
rs3178333 -- 73,568,000(-) gccgc(A/G)gaccc upstream-variant-2KB, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT2 Gene

Variant ID Type Subtype PubMed ID
dgv1958n71 CNV Gain 21882294
nsv510643 CNV Loss 20534489
dgv641e1 CNV Complex 17122850
nsv428295 CNV Gain 18775914
nsv832828 CNV Gain+Loss 17160897
nsv1350 CNV Loss 18451855
nsv9153 CNV Gain+Loss 18304495
nsv821106 CNV Deletion 20802225
nsv826976 CNV Loss 20364138
esv29080 CNV Gain+Loss 19812545
esv1006342 CNV Deletion 20482838
esv2748867 CNV Deletion 23290073
nsv902088 CNV Gain 21882294
esv29945 CNV Loss 18421352
esv33155 CNV Gain+Loss 17666407
nsv436178 CNV Deletion 17901297
esv2672436 CNV Deletion 23128226
nsv826985 CNV Loss 20364138
esv30006 CNV Gain 17803354
nsv826987 CNV Loss 20364138
nsv819954 CNV Gain 19587683
nsv826988 CNV Loss 20364138
nsv442346 CNV CNV 18776908
nsv514751 CNV Complex 21397061

Relevant External Links for ACOT2 Gene

HapMap Linkage Disequilibrium report

Disorders for ACOT2 Gene

Relevant External Links for ACOT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACOT2: view

No data available for UniProtKB/Swiss-Prot for ACOT2 Gene

Publications for ACOT2 Gene

  1. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PMID: 10944470) Jones J.M. … Gould S.J. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3

Products for ACOT2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ACOT2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ACOT2
    • Block miRNA regulation of ACOT2 using miScript Target Protectors

    Sources for ACOT2 Gene

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