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ACOT13 Gene

protein-coding   GIFtS: 49
GCID: GC06P024667

Acyl-CoA Thioesterase 13

(Previous name: thioesterase superfamily member 2)
(Previous symbol: THEM2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Thioesterase 131 2 3     Acyl-Coenzyme A Thioesterase 132
THEM21 2 3 5     Hypothalamus Protein HT0122
Thioesterase Superfamily Member 21 2 3     EC 3.1.2.-3
PNAS-272     

External Ids:    HGNC: 209991   Entrez Gene: 558562   Ensembl: ENSG000001123047   OMIM: 6156525   UniProtKB: Q9NPJ33   

Export aliases for ACOT13 gene to outside databases

Previous GC identifer: GC06P024776


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACOT13 Gene:
This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules
and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is
associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase.
Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, May
2009)

GeneCards Summary for ACOT13 Gene:
ACOT13 (acyl-CoA thioesterase 13) is a protein-coding gene. Diseases associated with ACOT13 include larynx verrucous carcinoma, and cutaneous anthrax. GO annotations related to this gene include acyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot: ACO13_HUMAN, Q9NPJ3
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty
acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT13 gene promoter:
         STAT5B   POU2F1   AML1a   FOXJ2 (long isoform)   POU2F1a   FOXJ2   FOXL1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT13 promoter sequence
   Search Chromatin IP Primers for ACOT13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.1

ACOT13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT13 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P024667:  view genomic region     (about GC identifiers)

Start:
24,667,263 bp from pter      End:
24,705,297 bp from pter
Size:
38,035 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACO13_HUMAN, Q9NPJ3 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 13  
Size: 140 amino acids; 14960 Da
Subunit: Homotetramer
3 PDB 3D structures from and Proteopedia for ACOT13:
2F0X (3D)        2H4U (3D)        3F5O (3D)    
Secondary accessions: F5H2L4 O95549
Alternative splicing: 2 isoforms:  Q9NPJ3-1   Q9NPJ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACOT13: NX_Q9NPJ3

Explore proteomics data for ACOT13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ACOT13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153566.1  NP_060943.1  

    ENSEMBL proteins: 
     ENSP00000230048   ENSP00000445552  

    ACOT13 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACOT: Acyl CoA thioesterases

    2 InterPro protein domains:
     IPR006683 Thioestr_supf
     IPR003736 PAAI_dom

    Graphical View of Domain Structure for InterPro Entry Q9NPJ3

    ProtoNet protein and cluster: Q9NPJ3

    UniProtKB/Swiss-Prot: ACO13_HUMAN, Q9NPJ3
    Similarity: Belongs to the thioesterase PaaI family


    ACOT13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACO13_HUMAN, Q9NPJ3
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
    fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
    fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty
    acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro)
    Biophysicochemical properties: Kinetic parameters: KM=4.9 uM for n-decanoyl-CoA; KM=26 uM for n-octanoyl-CoA; KM=5
    uM for myristoyl-CoA; KM=9 uM for palmitoyl-CoA; KM=9 uM for oleoyl-CoA; KM=10 uM for
    3,4-dihydroxyphenylacetyl-CoA; KM=40 uM for 3-hydroxyphenylacetyl-CoA;

         Enzyme Number (IUBMB): EC 3.1.2.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047617acyl-CoA hydrolase activity IDA16934754
         
    ACOT13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACOT13:
     Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acot13):
     adipose tissue  behavior/neurological  digestive/alimentary  growth/size/body  homeostasis/metabolism 
     liver/biliary system 

    ACOT13 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Acot13tm1Deco for ACOT13

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    Selected qRT-PCR Assays for microRNAs that regulate ACOT13 (see all 30):
    hsa-miR-3934 hsa-miR-448 hsa-miR-520f hsa-miR-3673 hsa-miR-125a-5p hsa-miR-125a-3p hsa-miR-3616-5p hsa-miR-513c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat ACOT13

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    GenScript: all cDNA clones in your preferred vector (see all 2): ACOT13 (NM_018473)
    Sino Biological Human cDNA Clone for ACOT13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT13

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACO13_HUMAN, Q9NPJ3: Cytoplasm (By similarity). Mitochondrion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    ACOT13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACOT13
    Interactions:

        Search GeneGlobe Interaction Network for ACOT13

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for ACOT13 (Q9NPJ33 ENSP000002300484) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP6Q7Z6E93, ENSP000003178724I2D: score=2 STRING: ENSP00000317872
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    EEF1GP266413I2D: score=4 
    CREB1P162203I2D: score=2 
    IKBKEQ141643I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process IDA16934754
    GO:0051289protein homotetramerization IPI16934754

    ACOT13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACOT13 (ACO13)

    1 DrugBank Compound for ACOT13    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    undecan-2-one-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ACOT13 gene (2 alternative transcripts): 
    NM_001160094.1  NM_018473.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230048 ENST00000476436 ENST00000537591(uc010jpv.3 uc003nek.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ACOT13 (see all 30):
    hsa-miR-3934 hsa-miR-448 hsa-miR-520f hsa-miR-3673 hsa-miR-125a-5p hsa-miR-125a-3p hsa-miR-3616-5p hsa-miR-513c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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    OriGene qPCR primer pairs and template standards for ACOT13
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT13
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      QuantiTect SYBR Green Assays in human, mouse, rat ACOT13
      QuantiFast Probe-based Assays in human, mouse, rat ACOT13

    Selected AceView cDNA sequences (see all 143):

    T94548 AA993303 AI418801 BQ056402 AI468265 BQ021097 BM793200 CK725038 
    AA939005 NM_018473 BU619130 CR610760 BU630938 BM824697 CA307718 BM794770 
    AK000508 BF437158 BQ008338 AF274952 BX090556 CA432016 BU622618 BP871111 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ACOT13    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:              -     -                           
    SP2:              -                                 
    SP3:                    -                           


    ECgene alternative splicing isoforms for ACOT13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACOT13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGAAGCA
    ACOT13 Expression
    About this image

    ACOT13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT13 Protein Expression
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACOT13 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot131 , 5 acyl-CoA thioesterase 131, 5 83.1(n)1
    83.57(a)1
      13 (10.69 cM)5
    668341  NM_025790.21  NP_080066.11 
     248179485 
    chicken
    (Gallus gallus)
    Aves ACOT136
    acyl-CoA thioesterase 13
    61(a)
    1 ↔ 1
    2(90244563-90249282)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    70(a)
    68(a)
    many → 1
    many → 1
    4(53948353-53953576)
    4(53958694-53961153)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.99732 Transcribed sequence with moderate similarity to protein more 75.74(n)    BG885538.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.136402 Transcribed sequence with moderate similarity to protein more 74.38(n)    BM035366.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169861 CG16986 46.25(n)
    39.53(a)
      38325  NM_139475.3  NP_647732.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F42H10.61 F42H10.6 51.2(n)
    42.4(a)
      176198  NM_066471.3  NP_498872.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G042901 AT1G04290 46.06(n)
    41.98(a)
      839552  NM_100310.5  NP_563705.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g04361001 Os04g0436100 48.87(n)
    39.81(a)
      4335905  NM_001059386.1  NP_001052851.1 


    ENSEMBL Gene Tree for ACOT13 (if available)
    TreeFam Gene Tree for ACOT13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACOT13 gene

    ACOT13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACOT13
    PGOHUM00000233639


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACOT13 (see all 771)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478251011,2
    --24669136(+) GGGGGC/TTTGGA 2 -- int10--------
    rs1849530451,2
    --24669210(+) AGTTCG/TAGGAA 2 -- int10--------
    rs1411878841,2
    --24669347(+) GTATCA/CGTTAA 2 -- int10--------
    rs122148011,2
    C,F--24669390(+) gcgcaC/Tgcagt 2 -- int18Minor allele frequency- T:0.16NA WA EA 368
    rs69367861,2
    C,F,H--24669401(+) GACACA/TGCCTC 2 -- int110Minor allele frequency- T:0.27NA WA CSA EA 372
    rs1894202531,2
    --24669432(+) GCCCAA/CGGTGG 2 -- int10--------
    rs122149031,2
    C,F--24669434(+) ccaagG/Atggtc 2 -- int12Minor allele frequency- A:0.25NA 4
    rs22235891,2
    C,F,H--24669472(-) tatatC/Gtccct 2 -- int112Minor allele frequency- G:0.18NA WA CSA EA 374
    rs1921771991,2
    --24669509(+) AACACG/TGGTTG 2 -- int10--------
    rs1845234661,2
    C--24669520(+) GGTTCA/GGAAAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ACOT13 (24667263 - 24705297 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACOT13:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2590495CNV Insertion19546169
    nsv512870CNV Insertion21212237

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACOT13
    DNA2.0 Custom Variant and Variant Library Synthesis for ACOT13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615652    OMIM disorders: --

    7 diseases for ACOT13:    
    About MalaCards
    larynx verrucous carcinoma    cutaneous anthrax    diphyllobothriasis    verrucous carcinoma
    dyslexia    malaria    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for ACOT13:
    Larynx verrucous carcinoma     Dyslexia     Cutaneous anthrax

    ACOT13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACOT13
    Human Genome Epidemiology (HuGE) Navigator: ACOT13 (0 documents)

    Export disorders for ACOT13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACOT13 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ACOT13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human thioesterase superfamily member 2. (PubMed id 16934754)1, 2, 3 Cheng Z....Gong W. (Biochem. Biophys. Res. Commun. 2006)
    2. The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. (PubMed id 19170545)1, 2, 9 Cao J.... Dunaway-Mariano D. (Biochemistry 2009)
    3. Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs. (PubMed id 19405909)1, 3 Wei J....Cohen D.E. (Biochem. J. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with developmental dyslexia. (PubMed id 23954868)1 Venkatesh S.K....Ramachandra N.B. (Gene 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55856 HGNC: 20999 AceView: THEM2 Ensembl:ENSG00000112304 euGenes: HUgn55856
    ECgene: ACOT13 H-InvDB: ACOT13

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACOT13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACOT13 gene:
    Search GeneIP for patents involving ACOT13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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