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Aliases for ACOT13 Gene

Aliases for ACOT13 Gene

  • Acyl-CoA Thioesterase 13 2 3 4 5
  • Thioesterase Superfamily Member 2 2 3 4
  • THEM2 3 4
  • Hypothalamus Protein HT012 3
  • EC 3.1.2.- 4
  • PNAS-27 3
  • HT012 3

External Ids for ACOT13 Gene

Previous HGNC Symbols for ACOT13 Gene

  • THEM2

Previous GeneCards Identifiers for ACOT13 Gene

  • GC06P024776

Summaries for ACOT13 Gene

Entrez Gene Summary for ACOT13 Gene

  • This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

GeneCards Summary for ACOT13 Gene

ACOT13 (Acyl-CoA Thioesterase 13) is a Protein Coding gene. Diseases associated with ACOT13 include larynx verrucous carcinoma and diphyllobothriasis. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include acyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot for ACOT13 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT13 Gene

Genomics for ACOT13 Gene

Regulatory Elements for ACOT13 Gene

Promoters for ACOT13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACOT13 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOT13 Gene

Chromosome:
6
Start:
24,667,035 bp from pter
End:
24,705,069 bp from pter
Size:
38,035 bases
Orientation:
Plus strand

Genomic View for ACOT13 Gene

Genes around ACOT13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT13 Gene

Proteins for ACOT13 Gene

  • Protein details for ACOT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPJ3-ACO13_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 13
    Protein Accession:
    Q9NPJ3
    Secondary Accessions:
    • F5H2L4
    • O95549

    Protein attributes for ACOT13 Gene

    Size:
    140 amino acids
    Molecular mass:
    14960 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for ACOT13 Gene

    Alternative splice isoforms for ACOT13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOT13 Gene

Proteomics data for ACOT13 Gene at MOPED

Post-translational modifications for ACOT13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ACOT13 (THEM2)

No data available for DME Specific Peptides for ACOT13 Gene

Domains & Families for ACOT13 Gene

Gene Families for ACOT13 Gene

Protein Domains for ACOT13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACOT13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPJ3

UniProtKB/Swiss-Prot:

ACO13_HUMAN :
  • Belongs to the thioesterase PaaI family.
Family:
  • Belongs to the thioesterase PaaI family.
genes like me logo Genes that share domains with ACOT13: view

Function for ACOT13 Gene

Molecular function for ACOT13 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.9 uM for n-decanoyl-CoA {ECO:0000269 PubMed:19170545}; KM=26 uM for n-octanoyl-CoA {ECO:0000269 PubMed:19170545}; KM=5 uM for myristoyl-CoA {ECO:0000269 PubMed:19170545}; KM=9 uM for palmitoyl-CoA {ECO:0000269 PubMed:19170545}; KM=9 uM for oleoyl-CoA {ECO:0000269 PubMed:19170545}; KM=10 uM for 3,4-dihydroxyphenylacetyl-CoA {ECO:0000269 PubMed:19170545}; KM=40 uM for 3-hydroxyphenylacetyl-CoA {ECO:0000269 PubMed:19170545};
UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).

Enzyme Numbers (IUBMB) for ACOT13 Gene

genes like me logo Genes that share phenotypes with ACOT13: view

Animal Models for ACOT13 Gene

MGI Knock Outs for ACOT13:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACOT13 Gene

Localization for ACOT13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT13 Gene

Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin. {ECO:0000250 UniProtKB:Q9CQR4}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT13 Gene COMPARTMENTS Subcellular localization image for ACOT13 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for ACOT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACOT13: view

Pathways & Interactions for ACOT13 Gene

genes like me logo Genes that share pathways with ACOT13: view

Gene Ontology (GO) - Biological Process for ACOT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ACOT13: view

No data available for SIGNOR curated interactions for ACOT13 Gene

Drugs & Compounds for ACOT13 Gene

(1) Drugs for ACOT13 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
undecan-2-one Experimental Pharma Target 0
genes like me logo Genes that share compounds with ACOT13: view

Transcripts for ACOT13 Gene

Unigene Clusters for ACOT13 Gene

Acyl-CoA thioesterase 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: -

Relevant External Links for ACOT13 Gene

GeneLoc Exon Structure for
ACOT13
ECgene alternative splicing isoforms for
ACOT13

Expression for ACOT13 Gene

mRNA expression in normal human tissues for ACOT13 Gene

Protein differential expression in normal tissues from HIPED for ACOT13 Gene

This gene is overexpressed in Liver, secretome (16.9), Liver (7.9), and Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ACOT13 Gene



SOURCE GeneReport for Unigene cluster for ACOT13 Gene Hs.731605

genes like me logo Genes that share expression patterns with ACOT13: view

Protein tissue co-expression partners for ACOT13 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACOT13 Gene

Orthologs for ACOT13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOT13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACOT13 35
  • 80 (n)
  • 72.59 (a)
THEM2 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOT13 35
  • 84.29 (n)
  • 77.86 (a)
ACOT13 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acot13 35
  • 83.1 (n)
  • 83.57 (a)
Acot13 16
Acot13 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACOT13 35
  • 99.76 (n)
  • 99.29 (a)
ACOT13 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acot13 35
  • 81.67 (n)
  • 81.43 (a)
oppossum
(Monodelphis domestica)
Mammalia ACOT13 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACOT13 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia acot13 35
  • 69.05 (n)
  • 70.71 (a)
Str.9973 35
zebrafish
(Danio rerio)
Actinopterygii acot13 35
  • 67.62 (n)
  • 71.43 (a)
Dr.13640 35
acot13 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007238 35
  • 47.87 (n)
  • 42.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16986 35
  • 46.25 (n)
  • 39.53 (a)
CG16985 36
  • 34 (a)
OneToMany
CG16986 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F42H10.6 35
  • 51.2 (n)
  • 42.4 (a)
C25H3.14 36
  • 39 (a)
OneToMany
C25H3.3 36
  • 40 (a)
OneToMany
F42H10.6 36
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G04290 35
  • 46.06 (n)
  • 41.98 (a)
rice
(Oryza sativa)
Liliopsida Os04g0436100 35
  • 48.87 (n)
  • 39.81 (a)
Species with no ortholog for ACOT13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOT13 Gene

ENSEMBL:
Gene Tree for ACOT13 (if available)
TreeFam:
Gene Tree for ACOT13 (if available)

Paralogs for ACOT13 Gene

Pseudogenes.org Pseudogenes for ACOT13 Gene

genes like me logo Genes that share paralogs with ACOT13: view

No data available for Paralogs for ACOT13 Gene

Variants for ACOT13 Gene

Sequence variations from dbSNP and Humsavar for ACOT13 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs926528 -- 24,687,771(-) atcgt(A/G)ccatt intron-variant
rs926529 -- 24,687,537(-) AAAGA(C/T)GACTT intron-variant, utr-variant-5-prime
rs1053598 -- 24,704,310(+) TCTGG(C/T)AACTT utr-variant-3-prime
rs1056317 -- 24,702,686(+) AAATA(A/G)AATAG utr-variant-3-prime
rs1056319 -- 24,702,818(+) CCGAG(A/C)ATAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACOT13 Gene

Variant ID Type Subtype PubMed ID
nsv512870 CNV Insertion 21212237
esv2590495 CNV Insertion 19546169

Variation tolerance for ACOT13 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT13 Gene

HapMap Linkage Disequilibrium report
ACOT13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT13 Gene

Disorders for ACOT13 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ACOT13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
larynx verrucous carcinoma
  • verrucous carcinoma of the larynx
diphyllobothriasis
  • diphyllobothrium infection
cutaneous anthrax
  • anthrax, skin type
spindle cell thymoma
  • medullary thymoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ACOT13

Genetic Association Database (GAD)
ACOT13
Human Genome Epidemiology (HuGE) Navigator
ACOT13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT13
genes like me logo Genes that share disorders with ACOT13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT13 Gene

Publications for ACOT13 Gene

  1. Crystal structure of human thioesterase superfamily member 2. (PMID: 16934754) Cheng Z. … Gong W. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 67
  2. Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs. (PMID: 19405909) Wei J. … Cohen D.E. (Biochem. J. 2009) 2 3
  3. The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. (PMID: 19170545) Cao J. … Dunaway-Mariano D. (Biochemistry 2009) 3 23
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Molecular mechanism of a hotdog-fold acyl-CoA thioesterase. (PMID: 24894958) Cantu D.C. … Reilly P.J. (Chemistry 2014) 3

Products for ACOT13 Gene

Sources for ACOT13 Gene

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