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Aliases for ACOT12 Gene

Aliases for ACOT12 Gene

  • Acyl-CoA Thioesterase 12 2 3 4
  • CACH 3 4 6
  • StAR-Related Lipid Transfer (START) Domain Containing 15 2 3
  • Cytoplasmic Acetyl-CoA Hydrolase 1 3 4
  • START Domain-Containing Protein 15 3 4
  • Acyl-CoA Thioester Hydrolase 12 3 4
  • EC 3.1.2.1 4 64
  • STARD15 3 4
  • HCACH-1 3 4
  • CACH-1 3 4
  • Acyl-Coenzyme A Thioesterase 12 3
  • Cytosolic Acetyl-CoA Hydrolase 3
  • CACH1 4
  • THEAL 3

External Ids for ACOT12 Gene

Summaries for ACOT12 Gene

GeneCards Summary for ACOT12 Gene

ACOT12 (Acyl-CoA Thioesterase 12) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism. GO annotations related to this gene include acetyl-CoA hydrolase activity. An important paralog of this gene is ACOT11.

UniProtKB/Swiss-Prot for ACOT12 Gene

  • Hydrolyzes acetyl-CoA to acetate and CoA.

Gene Wiki entry for ACOT12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT12 Gene

Genomics for ACOT12 Gene

Genomic Location for ACOT12 Gene

Start:
81,329,921 bp from pter
End:
81,394,179 bp from pter
Size:
64,259 bases
Orientation:
Minus strand

Genomic View for ACOT12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT12 Gene

Regulatory Elements for ACOT12 Gene

Proteins for ACOT12 Gene

  • Protein details for ACOT12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYK0-ACO12_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 12
    Protein Accession:
    Q8WYK0
    Secondary Accessions:
    • B3KVK9
    • Q5FWE9

    Protein attributes for ACOT12 Gene

    Size:
    555 amino acids
    Molecular mass:
    62034 Da
    Quaternary structure:
    • Homodimer or homotetramer.

    Three dimensional structures from OCA and Proteopedia for ACOT12 Gene

    Alternative splice isoforms for ACOT12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOT12 Gene

Proteomics data for ACOT12 Gene at MOPED

Selected DME Specific Peptides for ACOT12 Gene

Post-translational modifications for ACOT12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ACOT12 Gene

Gene Families for ACOT12 Gene

HGNC:
  • StARD :StAR-related lipid transfer (START) domain containing
  • ACOT :Acyl CoA thioesterases

Protein Domains for ACOT12 Gene

UniProtKB/Swiss-Prot:

ACO12_HUMAN
Domain:
  • Contains 2 acyl coenzyme A hydrolase domains.:
    • Q8WYK0
  • Contains 1 START domain.:
    • Q8WYK0
genes like me logo Genes that share domains with ACOT12: view

Function for ACOT12 Gene

Molecular function for ACOT12 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + H(2)O = CoA + acetate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by ADP. Active in the presence of ATP.
UniProtKB/Swiss-Prot Function: Hydrolyzes acetyl-CoA to acetate and CoA.

Enzyme Numbers (IUBMB) for ACOT12 Gene

Gene Ontology (GO) - Molecular Function for ACOT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003986 acetyl-CoA hydrolase activity ISS --
GO:0005524 ATP binding IEA --
GO:0008289 lipid binding IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT12: view

miRNA for ACOT12 Gene

miRTarBase miRNAs that target ACOT12

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACOT12 Gene

Localization for ACOT12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT12 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT12 Gene COMPARTMENTS Subcellular localization image for ACOT12 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACOT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with ACOT12: view

Pathways for ACOT12 Gene

SuperPathways for ACOT12 Gene

Superpath Contained pathways
1 Pyruvate metabolism
genes like me logo Genes that share pathways with ACOT12: view

Pathways by source for ACOT12 Gene

1 KEGG pathway for ACOT12 Gene

UniProtKB/Swiss-Prot Q8WYK0-ACO12_HUMAN

  • Pathway: Carbohydrate metabolism; pyruvate metabolism

Interacting Proteins for ACOT12 Gene

Gene Ontology (GO) - Biological Process for ACOT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006084 acetyl-CoA metabolic process IEA --
GO:0006090 pyruvate metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006637 acyl-CoA metabolic process ISS --
genes like me logo Genes that share ontologies with ACOT12: view

Compounds for ACOT12 Gene

(4) HMDB Compounds for ACOT12 Gene

Compound Synonyms Cas Number PubMed IDs
Acetic acid
  • Acetate
64-19-7
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with ACOT12: view

Transcripts for ACOT12 Gene

Unigene Clusters for ACOT12 Gene

Acyl-CoA thioesterase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2:

Relevant External Links for ACOT12 Gene

GeneLoc Exon Structure for
ACOT12
ECgene alternative splicing isoforms for
ACOT12

Expression for ACOT12 Gene

mRNA expression in normal human tissues for ACOT12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOT12 Gene

This gene is overexpressed in Liver (49.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACOT12 Gene

SOURCE GeneReport for Unigene cluster for ACOT12 Gene Hs.591756

genes like me logo Genes that share expressions with ACOT12: view

Orthologs for ACOT12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACOT12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT12 36
  • 99.16 (n)
  • 99.1 (a)
ACOT12 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACOT12 36
  • 88.59 (n)
  • 86.31 (a)
ACOT12 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACOT12 36
  • 88.07 (n)
  • 86.08 (a)
ACOT12 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acot12 36
  • 82.34 (n)
  • 81.67 (a)
Acot12 16
Acot12 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACOT12 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACOT12 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acot12 36
  • 81.31 (n)
  • 78.95 (a)
chicken
(Gallus gallus)
Aves ACOT12 36
  • 69.86 (n)
  • 63.47 (a)
ACOT12 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOT12 37
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9815 36
tropical clawed frog
(Silurana tropicalis)
Amphibia acot12 36
  • 65.44 (n)
  • 61.84 (a)
Str.1777 36
zebrafish
(Danio rerio)
Actinopterygii ACOT12 37
  • 51 (a)
OneToOne
LOC100536873 36
  • 60.46 (n)
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for ACOT12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOT12 Gene

ENSEMBL:
Gene Tree for ACOT12 (if available)
TreeFam:
Gene Tree for ACOT12 (if available)

Paralogs for ACOT12 Gene

Paralogs for ACOT12 Gene

Selected SIMAP similar genes for ACOT12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOT12: view

Variants for ACOT12 Gene

Sequence variations from dbSNP and Humsavar for ACOT12 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9546 -- 81,330,127(+) TAGTA(C/T)TGCAT downstream-variant-500B, utr-variant-3-prime
rs10371 - 81,335,823(+) ATAAG(C/T)CAAAT missense, reference, intron-variant
rs1366597 -- 81,394,425(+) TTTGA(C/G)ATAAA upstream-variant-2KB
rs1896775 -- 81,380,721(+) TTGAA(A/T)AATGT intron-variant
rs2059894 -- 81,370,016(+) GCTCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT12 Gene

Variant ID Type Subtype PubMed ID
esv2730381 CNV Deletion 23290073
esv2661818 CNV Deletion 23128226

Relevant External Links for ACOT12 Gene

HapMap Linkage Disequilibrium report
ACOT12

Disorders for ACOT12 Gene

Relevant External Links for ACOT12

Genetic Association Database (GAD)
ACOT12
Human Genome Epidemiology (HuGE) Navigator
ACOT12
genes like me logo Genes that share disorders with ACOT12: view

No data available for UniProtKB/Swiss-Prot for ACOT12 Gene

Publications for ACOT12 Gene

  1. Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase. (PMID: 16951743) Suematsu N. … Isohashi F. (Acta Biochim. Pol. 2006) 3 4 23
  2. Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase. (PMID: 11322891) Suematsu N. … Isohashi F. (Eur. J. Biochem. 2001) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3

Products for ACOT12 Gene

Sources for ACOT12 Gene

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