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Aliases for ACOT12 Gene

Aliases for ACOT12 Gene

  • Acyl-CoA Thioesterase 12 2 3 4 5
  • StAR-Related Lipid Transfer (START) Domain Containing 15 2 3
  • Cytoplasmic Acetyl-CoA Hydrolase 1 3 4
  • START Domain-Containing Protein 15 3 4
  • Acyl-CoA Thioester Hydrolase 12 3 4
  • EC 4 63
  • STARD15 3 4
  • HCACH-1 3 4
  • CACH-1 3 4
  • Cach 3 4
  • Cytosolic Acetyl-CoA Hydrolase 3
  • THEAL 3
  • CACH1 4

External Ids for ACOT12 Gene

Previous GeneCards Identifiers for ACOT12 Gene

  • GC05M080662
  • GC05M075834
  • GC05M080625

Summaries for ACOT12 Gene

GeneCards Summary for ACOT12 Gene

ACOT12 (Acyl-CoA Thioesterase 12) is a Protein Coding gene. Diseases associated with ACOT12 include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include lipid binding and acetyl-CoA hydrolase activity. An important paralog of this gene is ACOT7.

UniProtKB/Swiss-Prot for ACOT12 Gene

  • Hydrolyzes acetyl-CoA to acetate and CoA.

Gene Wiki entry for ACOT12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT12 Gene

Genomics for ACOT12 Gene

Regulatory Elements for ACOT12 Gene

Enhancers for ACOT12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACOT12 on UCSC Golden Path with GeneCards custom track

Promoters for ACOT12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACOT12 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOT12 Gene

81,329,991 bp from pter
81,394,179 bp from pter
64,189 bases
Minus strand

Genomic View for ACOT12 Gene

Genes around ACOT12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT12 Gene

Proteins for ACOT12 Gene

  • Protein details for ACOT12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A thioesterase 12
    Protein Accession:
    Secondary Accessions:
    • B3KVK9
    • Q5FWE9

    Protein attributes for ACOT12 Gene

    555 amino acids
    Molecular mass:
    62034 Da
    Quaternary structure:
    • Homodimer or homotetramer.

    Three dimensional structures from OCA and Proteopedia for ACOT12 Gene

    Alternative splice isoforms for ACOT12 Gene


neXtProt entry for ACOT12 Gene

Proteomics data for ACOT12 Gene at MOPED

Selected DME Specific Peptides for ACOT12 Gene

Post-translational modifications for ACOT12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACOT12 Gene

Protein Domains for ACOT12 Gene

Suggested Antigen Peptide Sequences for ACOT12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 HotDog ACOT-type domains.
  • Contains 2 HotDog ACOT-type domains.
  • Contains 1 START domain.
genes like me logo Genes that share domains with ACOT12: view

Function for ACOT12 Gene

Molecular function for ACOT12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + H(2)O = CoA + acetate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by ADP. Active in the presence of ATP.
UniProtKB/Swiss-Prot Function:
Hydrolyzes acetyl-CoA to acetate and CoA.

Enzyme Numbers (IUBMB) for ACOT12 Gene

Gene Ontology (GO) - Molecular Function for ACOT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003986 acetyl-CoA hydrolase activity ISS --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT12: view
genes like me logo Genes that share phenotypes with ACOT12: view

Animal Model Products

miRNA for ACOT12 Gene

miRTarBase miRNAs that target ACOT12

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOT12 Gene

Localization for ACOT12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT12 Gene


Subcellular locations from

Jensen Localization Image for ACOT12 Gene COMPARTMENTS Subcellular localization image for ACOT12 gene
Compartment Confidence
cytosol 4
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for ACOT12 Gene

Pathways & Interactions for ACOT12 Gene

genes like me logo Genes that share pathways with ACOT12: view

UniProtKB/Swiss-Prot Q8WYK0-ACO12_HUMAN

  • Pathway: Carbohydrate metabolism; pyruvate metabolism.

Interacting Proteins for ACOT12 Gene

Gene Ontology (GO) - Biological Process for ACOT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006084 acetyl-CoA metabolic process IEA --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ACOT12: view

No data available for SIGNOR curated interactions for ACOT12 Gene

Drugs & Compounds for ACOT12 Gene

(2) Drugs for ACOT12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
acetic acid Approved Nutra Full agonist, Agonist 97
Coenzyme A Nutra 0

(2) Additional Compounds for ACOT12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with ACOT12: view

Transcripts for ACOT12 Gene

Unigene Clusters for ACOT12 Gene

Acyl-CoA thioesterase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b

Relevant External Links for ACOT12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOT12 Gene

mRNA expression in normal human tissues for ACOT12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOT12 Gene

This gene is overexpressed in Liver (x49.1).

Protein differential expression in normal tissues from HIPED for ACOT12 Gene

This gene is overexpressed in Plasma (35.2), Liver (23.5), and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACOT12 Gene

SOURCE GeneReport for Unigene cluster for ACOT12 Gene Hs.591756

genes like me logo Genes that share expression patterns with ACOT12: view

Protein tissue co-expression partners for ACOT12 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ACOT12 Gene

Orthologs for ACOT12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACOT12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACOT12 35
  • 88.59 (n)
  • 86.31 (a)
ACOT12 36
  • 86 (a)
(Canis familiaris)
Mammalia ACOT12 35
  • 88.07 (n)
  • 86.08 (a)
ACOT12 36
  • 83 (a)
(Mus musculus)
Mammalia Acot12 35
  • 82.34 (n)
  • 81.67 (a)
Acot12 16
Acot12 36
  • 81 (a)
(Pan troglodytes)
Mammalia ACOT12 35
  • 99.16 (n)
  • 99.1 (a)
ACOT12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Acot12 35
  • 81.31 (n)
  • 78.95 (a)
(Monodelphis domestica)
Mammalia ACOT12 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia ACOT12 36
  • 70 (a)
(Gallus gallus)
Aves ACOT12 35
  • 69.86 (n)
  • 63.47 (a)
ACOT12 36
  • 61 (a)
(Anolis carolinensis)
Reptilia ACOT12 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acot12 35
  • 65.44 (n)
  • 61.84 (a)
Str.1777 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9815 35
(Danio rerio)
Actinopterygii LOC100536873 35
  • 60.46 (n)
  • 54 (a)
ACOT12 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for ACOT12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOT12 Gene

Gene Tree for ACOT12 (if available)
Gene Tree for ACOT12 (if available)

Paralogs for ACOT12 Gene

Paralogs for ACOT12 Gene

(1) SIMAP similar genes for ACOT12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACOT12: view

Variants for ACOT12 Gene

Sequence variations from dbSNP and Humsavar for ACOT12 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34607174 - 81,345,970(+) ATCTA(C/T)GGACT reference, missense
rs10371 - 81,335,823(+) ATAAG(C/T)CAAAT intron-variant, reference, missense
VAR_064691 -
rs9546 -- 81,330,127(+) TAGTA(C/T)TGCAT downstream-variant-500B, utr-variant-3-prime
rs3052892 -- 81,380,534(+) CTTCA(-/CTTCA)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT12 Gene

Variant ID Type Subtype PubMed ID
esv2730381 CNV Deletion 23290073
esv2661818 CNV Deletion 23128226

Variation tolerance for ACOT12 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACOT12 Gene

Disorders for ACOT12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACOT12 Gene - From: OMIM

Disorder Aliases PubMed IDs
leukoencephalopathy with vanishing white matter
  • leukoencephaly with vanishing white matter
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ACOT12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ACOT12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT12 Gene

Publications for ACOT12 Gene

  1. Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase. (PMID: 16951743) Suematsu N. … Isohashi F. (Acta Biochim. Pol. 2006) 3 4 23 67
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3
  3. Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase. (PMID: 11322891) Suematsu N. … Isohashi F. (Eur. J. Biochem. 2001) 3 23
  4. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M. … Ahsan H. (J. Med. Genet. 2014) 3
  5. Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain. (PMID: 25002576) Swarbrick C.M. … Forwood J.K. (J. Biol. Chem. 2014) 3

Products for ACOT12 Gene

Sources for ACOT12 Gene