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ACOT12 Gene

protein-coding   GIFtS: 55
GCID: GC05M080625

Acyl-CoA Thioesterase 12

  Search for ACOT12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Thioesterase 121 2 3     EC 3.1.2.13 8
StAR-Related Lipid Transfer (START) Domain Containing 151 2     CACH3 5
Acyl-CoA Thioester Hydrolase 122 3     Cach2
Cytoplasmic Acetyl-CoA Hydrolase 12 3     THEAL2
CACH-12 3     Acyl-Coenzyme A Thioesterase 122
STARD152 3     Cytosolic Acetyl-CoA Hydrolase2
hCACH-12 3     CACH13
START Domain-Containing Protein 152 3     StARD153

External Ids:    HGNC: 244361   Entrez Gene: 1345262   Ensembl: ENSG000001724977   OMIM: 6143155   UniProtKB: Q8WYK03   

Export aliases for ACOT12 gene to outside databases

Previous GC identifers: GC05M080662 GC05M075834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ACOT12 Gene:
ACOT12 (acyl-CoA thioesterase 12) is a protein-coding gene. GO annotations related to this gene include and acetyl-CoA hydrolase activity. An important paralog of this gene is ACOT11.

UniProtKB/Swiss-Prot: ACO12_HUMAN, Q8WYK0
Function: Hydrolyzes acetyl-CoA to acetate and CoA

Gene Wiki entry for ACOT12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT12 gene promoter:
         Nkx3-1   Nkx3-1 v1   GATA-1   NF-AT   Nkx3-1 v2   AREB6   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT12 promoter sequence
   Search Chromatin IP Primers for ACOT12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.1   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

ACOT12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT12 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M080625:  view genomic region     (about GC identifiers)

Start:
80,625,824 bp from pter      End:
80,689,998 bp from pter
Size:
64,175 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACO12_HUMAN, Q8WYK0 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 12  
Size: 555 amino acids; 62034 Da
Subunit: Homodimer or homotetramer (By similarity)
1 PDB 3D structure from and Proteopedia for ACOT12:
3B7K (3D)    
Secondary accessions: B3KVK9

Explore the universe of human proteins at neXtProt for ACOT12: NX_Q8WYK0

Explore proteomics data for ACOT12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ACOT12 (Q8WYK0)
     RHINSAF  ELVLPPHANH  GNTFGGQIMAWME 


    See ACOT12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_570123.1  
    ENSEMBL proteins: 
     ENSP00000303246   ENSP00000421628  

    ACOT12 Human Recombinant Protein Products:

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    OriGene MassSpec for ACOT12
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    Novus Biologicals ACOT12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACOT12

     
    Search eBioscience for Proteins for ACOT12 

    ACOT12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ACOT12
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    LSBio Antibodies in human, mouse, rat for ACOT12

    ACOT12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACOT12
    Cloud-Clone Corp. CLIAs for ACOT12
    Search eBioscience for ELISAs for ACOT12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    StARD: StAR-related lipid transfer (START) domain containing
    ACOT: Acyl CoA thioesterases

    3 InterPro protein domains:
     IPR006683 Thioestr_supf
     IPR023393 START-like_dom
     IPR002913 START_lipid-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8WYK0

    ProtoNet protein and cluster: Q8WYK0

    UniProtKB/Swiss-Prot: ACO12_HUMAN, Q8WYK0
    Similarity: Contains 2 acyl coenzyme A hydrolase domains
    Similarity: Contains 1 START domain


    Find genes that share domains with ACOT12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACO12_HUMAN, Q8WYK0
    Function: Hydrolyzes acetyl-CoA to acetate and CoA
    Catalytic activity: Acetyl-CoA + H(2)O = CoA + acetate
    Enzyme regulation: Inhibited by ADP. Active in the presence of ATP

         Enzyme Number (IUBMB): EC 3.1.2.11 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003986acetyl-CoA hydrolase activity ISS--
    GO:0005524ATP binding IEA--
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with ACOT12           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACOT12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACOT12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACOT12

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACOT12:
    hsa-mir-181a-5p (MIRT025162), hsa-mir-186-5p (MIRT045136)

    Block miRNA regulation of human, mouse, rat ACOT12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ACOT12:
    hsa-miR-217
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACOT12
    Predesigned siRNA for gene silencing in human, mouse, rat ACOT12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACOT12

    Clone
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    OriGene ORF clones in mouse, rat for ACOT12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACOT12 (NM_130767)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT12

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ACOT12 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACO12_HUMAN, Q8WYK0: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    peroxisome2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--

    Find genes that share ontologies with ACOT12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACOT12 About    
    See pathways by source

    SuperPathContained pathways About
    1Pyruvate metabolism
    Pyruvate metabolism


    Find genes that share SuperPaths with ACOT12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for ACOT12):
        Pyruvate metabolism

    UniProtKB/Swiss-Prot: ACO12_HUMAN, Q8WYK0
    Pathway: Carbohydrate metabolism; pyruvate metabolism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT12: 

              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ACOT12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for ACOT12 (ENSP000003032464) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACAT1ENSP000002658384STRING: ENSP00000265838
    ACAT2ENSP000003560154STRING: ENSP00000356015
    ACSS2ENSP000003538044STRING: ENSP00000353804
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    ALDH2ENSP000002617334STRING: ENSP00000261733
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006084acetyl-CoA metabolic process IEA--
    GO:0006090pyruvate metabolic process IEA--
    GO:0006631fatty acid metabolic process IEA--
    GO:0006637acyl-CoA metabolic process ISS--

    Find genes that share ontologies with ACOT12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACOT12 (ACO12)

    4 HMDB Compounds for ACOT12    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACOT12 gene: 
    NM_130767.2  

    Unigene Cluster for ACOT12:

    Acyl-CoA thioesterase 12
    Hs.591756  [show with all ESTs]
    Unigene Representative Sequence: AK122960
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307624(uc003khl.4) ENST00000508234 ENST00000506440 ENST00000513751(uc003khm.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACOT12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ACOT12:
    hsa-miR-217
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACOT12
    Predesigned siRNA for gene silencing in human, mouse, rat ACOT12
    Clone
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    OriGene clones in human, mouse for ACOT12 (see all 5)
    OriGene ORF clones in mouse, rat for ACOT12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACOT12 (NM_130767)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT12
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACOT12
      QuantiTect SYBR Green Assays in human, mouse, rat ACOT12
      QuantiFast Probe-based Assays in human, mouse, rat ACOT12

    Additional mRNA sequence: 

    AB078619.1 AK122960.1 BC075010.2 BC075011.2 BC089437.1 

    5 DOTS entries:

    DT.95151279  DT.213999  DT.101966401  DT.40244066  DT.91976504 

    Selected AceView cDNA sequences (see all 39):

    W93197 BG567019 AK122960 BC075010 BC075011 BX094510 BG190322 W88442 
    BX102586 NM_130767 H38009 CF129788 AA701993 AI075132 H38712 AB078619 
    W89206 H59947 W93105 H38236 AV685167 AV693695 R16116 H70112 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ACOT12    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                
    SP2:                                                                                                


    ECgene alternative splicing isoforms for ACOT12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACOT12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATACCTT
    ACOT12 Expression
    About this image


    ACOT12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    ACOT12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591756
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT12: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACOT12
    QuantiTect SYBR Green Assays in human, mouse, rat ACOT12
    QuantiFast Probe-based Assays in human, mouse, rat ACOT12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ACOT12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot121 , 5 acyl-CoA thioesterase 121, 5 82.34(n)1
    81.67(a)1
      13 (47.43 cM)5
    741561  NM_028790.31  NP_083066.11 
     917415125 
    chicken
    (Gallus gallus)
    Aves ACOT121 acyl-CoA thioesterase 12 69.86(n)
    63.47(a)
      431627  XM_429179.4  XP_429179.3 
    lizard
    (Anolis carolinensis)
    Reptilia ACOT126
    acyl-CoA thioesterase 12
    56(a)
    1 ↔ 1
    2(17489364-17537800)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98152 Xenopus laevis transcribed sequence with weak similarity more 79.73(n)    BX846471.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005368731 acyl-coenzyme A thioesterase 12-like 60.46(n)
    54(a)
      100536873  XM_003199391.2  XP_003199439.2 


    ENSEMBL Gene Tree for ACOT12 (if available)
    TreeFam Gene Tree for ACOT12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACOT12 gene
    ACOT112  
    1 SIMAP similar gene for ACOT12 using alignment to 2 protein entries:     ACO12_HUMAN (see all proteins):
    ACOT11

    Find genes that share paralogs with ACOT12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACOT12 (see all 1478)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463503311,2
    --80625492(+) ATACTA/GAATGT 1 -- ds50010--------
    rs744397331,2
    F--80625573(+) TAATAC/TTACAT 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1873038091,2
    --80625634(+) GCCACC/GTGGAA 1 -- ds50010--------
    rs339571451,2
    C--80625657(+) ACACA-/AAGT  
            
    AAGTT
    1 -- ds50010--------
    rs106262031,2
    C--80625658(+) CACAA-/GT    
       
    /GTAA
    AGTTG
    1 -- ds50011NA 2
    rs1919331781,2
    --80625707(+) AATGTC/TTCCCT 1 -- ds50010--------
    rs1430828441,2
    C--80625889(+) AACCT-/AAAAAA 1 -- ds50010--------
    rs95461,2
    C,F,A,H--80625946(+) TAGTAC/TTGCAT 1 -- ds5001 ese328Minor allele frequency- T:0.48MN NS EA NA WA CSA 3127
    rs1829086761,2
    --80626060(+) TTGACC/TTAAGA 1 -- ut310--------
    rs1397636951,2
    C--80626067(+) AAGATA/GCATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ACOT12 (80625824 - 80689998 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACOT12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730381CNV Deletion23290073
    esv2661818CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACOT12
    DNA2.0 Custom Variant and Variant Library Synthesis for ACOT12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614315    OMIM disorders: --


    Find genes that share disorders with ACOT12           About GenesLikeMe

    Genetic Association Database (GAD): ACOT12
    Human Genome Epidemiology (HuGE) Navigator: ACOT12 (1 document)

    Export disorders for ACOT12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACOT12 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ACOT12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase. (PubMed id 16951743)1, 2, 9 Suematsu N. and Isohashi F. (Acta Biochim. Pol. 2006)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (J. Lipid Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase. (PubMed id 11322891)1, 9 Suematsu N....Isohashi F. (Eur. J. Biochem. 2001)
    7. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. (PubMed id 22863734)1 Ludwig K.U....NAPthen M.M. (Nat. Genet. 2012)
    8. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)
    9. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PubMed id 16940157)3 Hunt M.C.... Alexson S.E.H. (FASEB J. 2006)
    10. Simple and unique purification by size-exclusion chromatography for an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A hydrolase. (PubMed id 12767336)1 Suematsu N....Isohashi F. (J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134526 HGNC: 24436 AceView: CACH-1 Ensembl:ENSG00000172497 euGenes: HUgn134526
    ECgene: ACOT12 Kegg: 134526 H-InvDB: ACOT12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ACOT12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACOT12 gene:
    Search GeneIP for patents involving ACOT12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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