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Aliases for ACOT11 Gene

Aliases for ACOT11 Gene

  • Acyl-CoA Thioesterase 11 2 3 4 5
  • StAR-Related Lipid Transfer (START) Domain Containing 14 2 3
  • Thioesterase, Adipose Associated 2 3
  • Brown Fat-Inducible Thioesterase 3 4
  • Acyl-CoA Thioester Hydrolase 11 3 4
  • Adipose-Associated Thioesterase 3 4
  • THEA 3 4
  • BFIT 3 4
  • Thioesterase Superfamily Member 1 3
  • Acyl-Coenzyme A Thioesterase 11 3
  • START Domain Containing 14 3
  • EC 3.1.2.1 61
  • EC 3.1.2.- 4
  • KIAA0707 4
  • STARD14 3
  • THEM1 3

External Ids for ACOT11 Gene

Previous HGNC Symbols for ACOT11 Gene

  • THEA

Previous GeneCards Identifiers for ACOT11 Gene

  • GC01P054720
  • GC01P054786
  • GC01P055007
  • GC01P053127

Summaries for ACOT11 Gene

Entrez Gene Summary for ACOT11 Gene

  • This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for ACOT11 Gene

ACOT11 (Acyl-CoA Thioesterase 11) is a Protein Coding gene. Diseases associated with ACOT11 include Obesity. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include lipid binding and acyl-CoA hydrolase activity. An important paralog of this gene is ACOT12.

UniProtKB/Swiss-Prot for ACOT11 Gene

  • Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.

Gene Wiki entry for ACOT11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT11 Gene

Genomics for ACOT11 Gene

Regulatory Elements for ACOT11 Gene

Enhancers for ACOT11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F054570 1.1 Ensembl ENCODE 14.9 +29.5 29544 2.4 TBP HDGF HDAC1 PKNOX1 ZBTB40 RAD21 YY1 SCRT2 ZBTB11 ELF1 ACOT11 MROH7 FAM151A
GH01F054569 0.9 Ensembl 14.5 +27.5 27544 1.2 HDGF HDAC1 PKNOX1 KLF17 FEZF1 ZBTB40 RAD21 YY1 CREM ZBTB11 ACOT11 TALDO1P1 TTC4 ENSG00000237453 TTC22 FAM151A
GH01F054579 1.1 Ensembl ENCODE 11.8 +40.1 40126 6.8 PKNOX1 ARID4B DMAP1 RAD21 RARA YY1 ZNF335 SCRT2 EGR2 SP5 MROH7 ACOT11 FAM151A
GH01F054567 0.6 Ensembl 11.7 +25.7 25744 1.2 SCRT1 CEBPB NR3C1 YY1 IKZF1 ZNF341 SCRT2 ZBTB33 ACOT11 TALDO1P1 TTC4 ENSG00000237453 TTC22 MROH7 FAM151A
GH01F054545 1 Ensembl ENCODE 6.1 +5.8 5832 4.2 CTCF TFAP4 PKNOX1 ESRRA ZNF792 ZMYM3 MAX ZNF48 ZIC2 RAD21 LOC105378734 ACOT11 MROH7 FAM151A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACOT11 on UCSC Golden Path with GeneCards custom track

Promoters for ACOT11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000536884 -57 1201 ARID4B DMAP1 ZNF48 ZNF2 GLIS2 KLF7 SP3 SP5 SMARCB1 SMARCA4

Genomic Location for ACOT11 Gene

Chromosome:
1
Start:
54,542,257 bp from pter
End:
54,639,192 bp from pter
Size:
96,936 bases
Orientation:
Plus strand

Genomic View for ACOT11 Gene

Genes around ACOT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT11 Gene

Proteins for ACOT11 Gene

  • Protein details for ACOT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXI4-ACO11_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 11
    Protein Accession:
    Q8WXI4
    Secondary Accessions:
    • B1AQ22
    • D3DQ50
    • O75187
    • Q52LP1
    • Q53ER9
    • Q96DI1
    • Q9H883

    Protein attributes for ACOT11 Gene

    Size:
    607 amino acids
    Molecular mass:
    68492 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31682.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACOT11 Gene

    Alternative splice isoforms for ACOT11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOT11 Gene

Selected DME Specific Peptides for ACOT11 Gene

Q8WXI4:
  • GNTFGGQIMAWME
  • ELVLPPHANH
  • RHINSAF

Post-translational modifications for ACOT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACOT11 Gene

Protein Domains for ACOT11 Gene

Suggested Antigen Peptide Sequences for ACOT11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXI4

UniProtKB/Swiss-Prot:

ACO11_HUMAN :
  • Contains 2 HotDog ACOT-type domains.
Domain:
  • Contains 2 HotDog ACOT-type domains.
  • Contains 1 START domain.
genes like me logo Genes that share domains with ACOT11: view

Function for ACOT11 Gene

Molecular function for ACOT11 Gene

UniProtKB/Swiss-Prot Function:
Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.
UniProtKB/Swiss-Prot Induction:
By cold exposure and repressed by heat exposure.

Enzyme Numbers (IUBMB) for ACOT11 Gene

Gene Ontology (GO) - Molecular Function for ACOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS 11696000
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT11: view
genes like me logo Genes that share phenotypes with ACOT11: view

Animal Models for ACOT11 Gene

MGI Knock Outs for ACOT11:

Animal Model Products

miRNA for ACOT11 Gene

miRTarBase miRNAs that target ACOT11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACOT11 Gene

Localization for ACOT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT11 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT11 gene
Compartment Confidence
extracellular 5
cytosol 5

Gene Ontology (GO) - Cellular Components for ACOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 11696000
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ACOT11: view

Pathways & Interactions for ACOT11 Gene

genes like me logo Genes that share pathways with ACOT11: view

Interacting Proteins for ACOT11 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360366%0d%0a9606.ENSP00000352706%0d%0a9606.ENSP00000267103%0d%0a9606.ENSP00000347548%0d%0a9606.ENSP00000363972%0d%0a9606.ENSP00000264167%0d%0a
Selected Interacting proteins: Q8WXI4-ACO11_HUMAN ENSP00000360366 for ACOT11 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ACOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process NAS 11696000
GO:0006637 acyl-CoA metabolic process IBA --
GO:0009266 response to temperature stimulus IEA,ISS --
GO:0009409 response to cold ISS 11696000
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with ACOT11: view

No data available for SIGNOR curated interactions for ACOT11 Gene

Drugs & Compounds for ACOT11 Gene

(1) Drugs for ACOT11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACOT11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT11: view

Transcripts for ACOT11 Gene

Unigene Clusters for ACOT11 Gene

Acyl-CoA thioesterase 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT11 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - -
SP8: - - - - - - - - - - -
SP9: -
SP10: - - -
SP11:
SP12: - - - - - - -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ACOT11 Gene

GeneLoc Exon Structure for
ACOT11
ECgene alternative splicing isoforms for
ACOT11

Expression for ACOT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACOT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOT11 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7).

Protein differential expression in normal tissues from HIPED for ACOT11 Gene

This gene is overexpressed in Stomach (12.9) and Rectum (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACOT11 Gene



NURSA nuclear receptor signaling pathways regulating expression of ACOT11 Gene:

ACOT11

SOURCE GeneReport for Unigene cluster for ACOT11 Gene:

Hs.745173

mRNA Expression by UniProt/SwissProt for ACOT11 Gene:

Q8WXI4-ACO11_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue.
genes like me logo Genes that share expression patterns with ACOT11: view

Primer Products

No data available for Protein tissue co-expression partners for ACOT11 Gene

Orthologs for ACOT11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACOT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT11 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia ACOT11 34 35
  • 90.4 (n)
mouse
(Mus musculus)
Mammalia Acot11 34 16 35
  • 86.32 (n)
rat
(Rattus norvegicus)
Mammalia Acot11 34
  • 85.53 (n)
cow
(Bos Taurus)
Mammalia ACOT11 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACOT11 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACOT11 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACOT11 34 35
  • 77.21 (n)
lizard
(Anolis carolinensis)
Reptilia ACOT11 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acot11 34
  • 67.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8808 34
zebrafish
(Danio rerio)
Actinopterygii acot11a 34 35
  • 66.61 (n)
acot11b 35
  • 60 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
Species where no ortholog for ACOT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOT11 Gene

ENSEMBL:
Gene Tree for ACOT11 (if available)
TreeFam:
Gene Tree for ACOT11 (if available)

Paralogs for ACOT11 Gene

Paralogs for ACOT11 Gene

(1) SIMAP similar genes for ACOT11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACOT11: view

Variants for ACOT11 Gene

Sequence variations from dbSNP and Humsavar for ACOT11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10533779 -- 54,601,117(+) CATAC(-/AT)GTGTG intron-variant
rs10712719 -- 54,584,290(+) TAGAG(-/A)GGCGA intron-variant
rs10788983 -- 54,553,670(+) taacc(A/G)tatca intron-variant
rs10788984 -- 54,613,531(+) gatcc(A/G)ctcac intron-variant
rs1084150 -- 54,555,254(-) gagcc(A/G)gacgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT11 Gene

Variant ID Type Subtype PubMed ID
esv3586095 CNV loss 21293372
esv3586093 CNV loss 21293372
esv3586091 CNV loss 21293372
esv3577865 CNV loss 25503493
esv3562137 CNV deletion 23714750
esv33550 CNV gain+loss 17666407
esv2748341 CNV deletion 23290073
esv2748330 CNV deletion 23290073
esv2673445 CNV deletion 23128226
esv2662697 CNV deletion 23128226
esv2651907 CNV deletion 19546169
esv2628077 CNV loss 19546169
esv24082 CNV gain+loss 19812545
esv2181722 CNV deletion 18987734
esv1004742 CNV gain 20482838
esv1002091 CNV gain 20482838
dgv39n67 CNV gain 20364138
dgv38n67 CNV loss 20364138
dgv38e212 CNV gain 25503493
dgv37e212 CNV loss 25503493
dgv36e212 CNV loss 25503493
dgv282n54 CNV loss 21841781
dgv281n54 CNV loss 21841781
dgv280n54 CNV loss 21841781
dgv279n54 CNV loss 21841781
dgv278n54 CNV loss 21841781
dgv20e214 CNV gain 21293372
nsv950750 CNV deletion 24416366
nsv910 CNV deletion 18451855
nsv829904 CNV loss 17160897
nsv822720 CNV loss 20364138
nsv822709 CNV gain 20364138
nsv822698 CNV gain+loss 20364138
nsv822642 CNV gain 20364138
nsv821518 CNV deletion 20802225
nsv820219 CNV gain 19587683
nsv817614 CNV gain 22305530
nsv546298 CNV loss 21841781
nsv546297 CNV gain 21841781
nsv546270 CNV loss 21841781
nsv546269 CNV gain 21841781
nsv546268 CNV gain 21841781
nsv546267 CNV gain 21841781
nsv546266 CNV gain 21841781
nsv516654 CNV loss 19592680
nsv461594 CNV gain 19166990
nsv461583 CNV gain 19166990
nsv461572 CNV gain 19166990
nsv461561 CNV gain 19166990
nsv1144376 CNV deletion 24896259
nsv1076457 CNV deletion 25765185
nsv1000673 CNV gain 25217958
esv3586099 CNV loss 21293372
esv3586098 CNV loss 21293372
esv3586097 CNV loss 21293372
esv3586096 CNV gain 21293372

Variation tolerance for ACOT11 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.57; 93.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT11 Gene

Disorders for ACOT11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACOT11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ACOT11

Genetic Association Database (GAD)
ACOT11
Human Genome Epidemiology (HuGE) Navigator
ACOT11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT11
genes like me logo Genes that share disorders with ACOT11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT11 Gene

Publications for ACOT11 Gene

  1. BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity. (PMID: 11696000) Adams S.H. … Lewin D.A. (Biochem. J. 2001) 2 3 4 22 64
  2. Comparative structural analysis of lipid binding START domains. (PMID: 21738568) Thorsell A.G. … Lehtio L. (PLoS ONE 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3 64

Products for ACOT11 Gene

Sources for ACOT11 Gene

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