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ACOT11 Gene

protein-coding   GIFtS: 52
GCID: GC01P055007

Acyl-CoA Thioesterase 11

(Previous names: thioesterase, adipose associated)
(Previous symbol: THEA)
  See ACOT11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Thioesterase 111 2 3     STARD142
THEA1 2 3 5     THEM12
BFIT2 3 5     Acyl-Coenzyme A Thioesterase 112
Thioesterase, Adipose Associated1 2     START Domain Containing 142
StAR-Related Lipid Transfer (START) Domain Containing 141 2     Thioesterase Superfamily Member 12
Acyl-CoA Thioester Hydrolase 112 3     EC 3.1.2.-3
Adipose-Associated Thioesterase2 3     BFIT15
Brown Fat-Inducible Thioesterase2 3     BFIT25
KIAA07073 5     EC 3.1.2.18

External Ids:    HGNC: 181561   Entrez Gene: 260272   Ensembl: ENSG000001623907   OMIM: 6068035   UniProtKB: Q8WXI43   

Export aliases for ACOT11 gene to outside databases

Previous GC identifers: GC01P054720 GC01P054786 GC01P053127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACOT11 Gene:
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty
acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown
adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of
the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of
acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. (provided by RefSeq,
Nov 2010)

GeneCards Summary for ACOT11 Gene:
ACOT11 (acyl-CoA thioesterase 11) is a protein-coding gene. Diseases associated with ACOT11 include obesity. GO annotations related to this gene include and acyl-CoA hydrolase activity. An important paralog of this gene is ACOT12.

UniProtKB/Swiss-Prot: ACO11_HUMAN, Q8WXI4
Function: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates

Gene Wiki entry for ACOT11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT11 gene promoter:
         USF1   C/EBPbeta   Nkx2-5   E47   POU2F1   USF-1   POU2F1b   POU2F1a   POU2F1c   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT11 promoter sequence
   Search Chromatin IP Primers for ACOT11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

ACOT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P055007:  view genomic region     (about GC identifiers)

Start:
55,007,930 bp from pter      End:
55,104,865 bp from pter
Size:
96,936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACO11_HUMAN, Q8WXI4 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 11  
Size: 607 amino acids; 68492 Da
Sequence caution: Sequence=BAA31682.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ACOT11:
3FO5 (3D)    
Secondary accessions: B1AQ22 D3DQ50 O75187 Q52LP1 Q53ER9 Q96DI1 Q9H883
Alternative splicing: 2 isoforms:  Q8WXI4-1   Q8WXI4-2   

Explore the universe of human proteins at neXtProt for ACOT11: NX_Q8WXI4

Explore proteomics data for ACOT11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ACOT11 (Q8WXI4)
     RHINSAF  ELVLPPHANH  GNTFGGQIMAWME 


    See ACOT11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056362.1  NP_671517.1  

    ENSEMBL proteins: 
     ENSP00000340260   ENSP00000360366  

    ACOT11 Human Recombinant Protein Products:

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    Novus Biologicals ACOT11 Proteins
    Novus Biologicals ACOT11 Lysate
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    Cloud-Clone Corp. Proteins for ACOT11

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    StARD: StAR-related lipid transfer (START) domain containing
    ACOT: Acyl CoA thioesterases

    3 InterPro protein domains:
     IPR006683 Thioestr_supf
     IPR023393 START-like_dom
     IPR002913 START_lipid-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8WXI4

    ProtoNet protein and cluster: Q8WXI4

    UniProtKB/Swiss-Prot: ACO11_HUMAN, Q8WXI4
    Similarity: Contains 2 acyl coenzyme A hydrolase domains
    Similarity: Contains 1 START domain


    Find genes that share domains with ACOT11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACO11_HUMAN, Q8WXI4
    Function: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates
    Induction: By cold exposure and repressed by heat exposure

         Enzyme Numbers (IUBMB): EC 3.1.2.12 EC 3.1.2.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--
    GO:0047617acyl-CoA hydrolase activity TAS11696000
         
    Find genes that share ontologies with ACOT11           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ACOT11:
     Decreased DCP1a protein expres  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acot11):
     adipose tissue  behavior/neurological  cellular  growth/size/body  homeostasis/metabolism 
     immune system  liver/biliary system 

    Find genes that share phenotypes with ACOT11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Acot11tm1Deco for ACOT11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT11
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACOT11

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    miRTarBase miRNAs that target ACOT11:
    hsa-mir-124-3p (MIRT022706)

    Block miRNA regulation of human, mouse, rat ACOT11 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ACOT11:
    hsa-miR-877* hsa-miR-196a* hsa-miR-1236 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidACOT11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ACOT11

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    Sino Biological Human cDNA Clone for ACOT11
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACO11_HUMAN, Q8WXI4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IC11696000
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ACOT11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACOT11
    Interactions:

        Search GeneGlobe Interaction Network for ACOT11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ACOT11 (ENSP000003603664) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNSTENSP000003554704STRING: ENSP00000355470
    DHCR24ENSP000003603164STRING: ENSP00000360316
    EFCAB2ENSP000003554804STRING: ENSP00000355480
    ENSG00000137345ENSP000002598914STRING: ENSP00000259891
    FAM151AENSP000003068884STRING: ENSP00000306888
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process NAS11696000
    GO:0009266response to temperature stimulus ISS--
    GO:0009409response to cold ISS11696000
    GO:0035556intracellular signal transduction NAS11696000

    Find genes that share ontologies with ACOT11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACOT11 (ACO11)

    Selected HMDB Compounds for ACOT11 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACOT11 gene (2 alternative transcripts): 
    NM_015547.3  NM_147161.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481208 ENST00000498228(uc001cxk.3) ENST00000343744(uc001cxj.2 uc001cxl.2)
    ENST00000371316(uc001cxm.2) ENST00000479837
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ACOT11:
    hsa-miR-877* hsa-miR-196a* hsa-miR-1236 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidACOT11 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ACOT11

    Selected AceView cDNA sequences (see all 54):

    NM_015547 NM_147161 AI636018 CD722495 BU632371 AU159322 AU141870 AL713723 
    AF416922 AK023937 CK001768 AK091112 BG427577 BI759394 BE042489 BM264599 
    AW087466 CB152012 BX955103 CD608336 BX332766 BX282220 BX332767 CK300575 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACOT11 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^
    SP1:                                            -     -     -     -     -                                                                 -                 -   
    SP2:                                            -     -     -     -     -                                                                 -                 -   
    SP3:                                                  -     -     -     -                                                                                       
    SP4:                                                              -     -                                                                                       
    SP5:              -     -     -     -     -     -     -     -     -     -                                                                                       

    ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                                            -               
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for ACOT11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACOT11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ACOT11 Expression
    About this image


    ACOT11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Thyroid (Endocrine System)
    ACOT11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT11 Protein Expression

    UniProtKB/Swiss-Prot: ACO11_HUMAN, Q8WXI4
    Tissue specificity: Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung
    and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ACOT11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot111 , 5 acyl-CoA thioesterase 111, 5 86.32(n)1
    89.7(a)1
      4 (49.75 cM)5
    3299101  NM_025590.41  NP_079866.21 
     1067445555 
    chicken
    (Gallus gallus)
    Aves ACOT111 acyl-CoA thioesterase 11 77.21(n)
    77.39(a)
      429108  XM_426664.4  XP_426664.3 
    lizard
    (Anolis carolinensis)
    Reptilia ACOT116
    acyl-CoA thioesterase 11
    65(a)
    1 ↔ 1
    4(104537433-104721139)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88082 Xenopus laevis transcribed sequence with moderate similarity more 78.53(n)    BX843189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii acot11a1 acyl-CoA thioesterase 11a 66.61(n)
    67.7(a)
      554842  NM_001099975.2  NP_001093445.1 


    ENSEMBL Gene Tree for ACOT11 (if available)
    TreeFam Gene Tree for ACOT11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACOT11 gene
    ACOT122  
    1 SIMAP similar gene for ACOT11 using alignment to 1 protein entry:     ACO11_HUMAN:
    ACOT12

    Find genes that share paralogs with ACOT11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACOT11 (see all 1762)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867348861,2
    --55011879(+) CTCTCA/GTAAGT 2 -- us2k10--------
    rs1166411051,2
    F--55011983(+) TCACTG/ATGTGT 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1911474201,2
    --55012002(+) GCCTCA/GCTTTC 2 -- us2k10--------
    rs1421030611,2
    C--55012006(+) CACTTC/TCCTCC 2 -- us2k10--------
    rs1390496361,2
    --55012093(+) GAGAGA/GGTAGG 2 -- us2k10--------
    rs1833619791,2
    --55012110(+) AGCCAG/TGAGCT 2 -- us2k10--------
    rs766987951,2
    F--55012143(+) CTGCAG/AAGGGA 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs799598831,2
    F--55012145(+) GCAGAG/AGGAGG 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1439656781,2
    --55012199(+) CCATAA/CGATGA 2 -- us2k10--------
    rs1876601651,2
    --55012226(+) GCTGAC/TTTCCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACOT11 (55007930 - 55104865 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ACOT11 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673445CNV Deletion23128226
    esv2651907CNV Deletion19546169
    esv2748341CNV Deletion23290073
    esv2748330CNV Deletion23290073
    nsv821518CNV Deletion20802225
    esv2181722CNV Deletion18987734
    esv2662697CNV Deletion23128226
    nsv516654CNV Loss19592680
    nsv829904CNV Loss17160897
    esv2628077CNV Loss19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACOT11
    DNA2.0 Custom Variant and Variant Library Synthesis for ACOT11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606803    OMIM disorders: --

    1 disease for ACOT11:    
    About MalaCards
    obesity


    Find genes that share disorders with ACOT11           About GenesLikeMe

    Genetic Association Database (GAD): ACOT11
    Human Genome Epidemiology (HuGE) Navigator: ACOT11 (4 documents)

    Export disorders for ACOT11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACOT11 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ACOT11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity. (PubMed id 11696000)1, 2, 3, 9 Adams S.H.... Lewin D.A. (Biochem. J. 2001)
    2. Comparative structural analysis of lipid binding START domains. (PubMed id 21738568)1, 2 Thorsell A.G.... Lehtio L. (PLoS ONE 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (J. Lipid Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    9. Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function. (PubMed id 22897136)1 Chen D....Dunaway-Mariano D. (Biochemistry 2012)
    10. Functional and structural properties of mammalian acyl-coenzyme A thioesterases. (PubMed id 20470824)1 Kirkby B....Forwood J.K. (Prog. Lipid Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26027 HGNC: 18156 AceView: THEA Ensembl:ENSG00000162390 euGenes: HUgn26027
    ECgene: ACOT11 H-InvDB: ACOT11

    (According to HUGE)
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    HUGE: KIAA0707

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACOT11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACOT11 gene:
    Search GeneIP for patents involving ACOT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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