Aliases for ACOT11 Gene
External Ids for ACOT11 Gene
Previous HGNC Symbols for ACOT11 Gene
Previous GeneCards Identifiers for ACOT11 Gene
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
GeneCards Summary for ACOT11 Gene
ACOT11 (Acyl-CoA Thioesterase 11) is a Protein Coding gene. Diseases associated with ACOT11 include Obesity. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include lipid binding and acyl-CoA hydrolase activity. An important paralog of this gene is ACOT12.
UniProtKB/Swiss-Prot for ACOT11 Gene
Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.