Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACOT1 Gene

Aliases for ACOT1 Gene

  • Acyl-CoA Thioesterase 1 2 3 4 5
  • Inducible Cytosolic Acyl-Coenzyme A Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Hydrolase 3 4
  • EC 3.1.2.2 4 61
  • CTE-Ib 3 4
  • CTE-I 3 4
  • Acyl-Coenzyme A Thioesterase 1 3
  • CTE-1 3
  • LACH2 3
  • ACH2 3
  • CTE1 4

External Ids for ACOT1 Gene

Previous GeneCards Identifiers for ACOT1 Gene

  • GC14U900538
  • GC14P073074
  • GC14P074003
  • GC14P054170
  • GC14P073537

Summaries for ACOT1 Gene

GeneCards Summary for ACOT1 Gene

ACOT1 (Acyl-CoA Thioesterase 1) is a Protein Coding gene. Diseases associated with ACOT1 include Human Immunodeficiency Virus Infectious Disease. Among its related pathways are palmitate biosynthesis and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include hydrolase activity and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT2.

UniProtKB/Swiss-Prot for ACOT1 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT1 Gene

Genomics for ACOT1 Gene

Regulatory Elements for ACOT1 Gene

Enhancers for ACOT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ACOT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOT1 Gene

Chromosome:
14
Start:
73,493,234 bp from pter
End:
73,543,799 bp from pter
Size:
50,566 bases
Orientation:
Plus strand

Genomic View for ACOT1 Gene

Genes around ACOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT1 Gene

Proteins for ACOT1 Gene

  • Protein details for ACOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TX2-ACOT1_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 1
    Protein Accession:
    Q86TX2
    Secondary Accessions:
    • A1L173
    • Q3I5F9

    Protein attributes for ACOT1 Gene

    Size:
    421 amino acids
    Molecular mass:
    46277 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for ACOT1 Gene

Post-translational modifications for ACOT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACOT1 Gene

Gene Families for ACOT1 Gene

Suggested Antigen Peptide Sequences for ACOT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86TX2

UniProtKB/Swiss-Prot:

ACOT1_HUMAN :
  • Belongs to the C/M/P thioester hydrolase family.
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT1: view

Function for ACOT1 Gene

Molecular function for ACOT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=35.8 uM for C10-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C12-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.8 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C16-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C18-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2 uM for C20-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.1 uM for C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.1 uM for C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=224 nmol/min/mg enzyme toward C10-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=700 nmol/min/mg enzyme toward C12-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=912 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=691 nmol/min/mg enzyme toward C16-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=597 nmol/min/mg enzyme toward C18-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=520 nmol/min/mg enzyme toward C20-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=577 nmol/min/mg enzyme toward C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=258 nmol/min/mg enzyme toward C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate.
UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

Enzyme Numbers (IUBMB) for ACOT1 Gene

Gene Ontology (GO) - Molecular Function for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT1: view

Phenotypes for ACOT1 Gene

GenomeRNAi human phenotypes for ACOT1:
genes like me logo Genes that share phenotypes with ACOT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACOT1 Gene

Localization for ACOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT1 Gene COMPARTMENTS Subcellular localization image for ACOT1 gene
Compartment Confidence
cytosol 5
peroxisome 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACOT1: view

Pathways & Interactions for ACOT1 Gene

genes like me logo Genes that share pathways with ACOT1: view

Interacting Proteins for ACOT1 Gene

Gene Ontology (GO) - Biological Process for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process IDA 16940157
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with ACOT1: view

No data available for SIGNOR curated interactions for ACOT1 Gene

Drugs & Compounds for ACOT1 Gene

(12) Drugs for ACOT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Gamma-Homolinolenic acid Approved Nutra 0
Icosapent Approved Nutra Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 0

(42) Additional Compounds for ACOT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT1: view

Transcripts for ACOT1 Gene

mRNA/cDNA for ACOT1 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT1 Gene

Acyl-CoA thioesterase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT1 Gene

No ASD Table

Relevant External Links for ACOT1 Gene

GeneLoc Exon Structure for
ACOT1
ECgene alternative splicing isoforms for
ACOT1

Expression for ACOT1 Gene

mRNA expression in normal human tissues for ACOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACOT1 Gene

This gene is overexpressed in Nasopharynx (14.1) and Skin (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACOT1 Gene



Protein tissue co-expression partners for ACOT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACOT1 Gene:

ACOT1

SOURCE GeneReport for Unigene cluster for ACOT1 Gene:

Hs.568046
genes like me logo Genes that share expression patterns with ACOT1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACOT1 Gene

Orthologs for ACOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Acot3 34
  • 82.5 (n)
  • 76.72 (a)
Acot3 16
Acot1 35
  • 77 (a)
ManyToMany
Acot2 35
  • 71 (a)
ManyToMany
Acot3 35
  • 75 (a)
ManyToMany
Acot5 35
  • 74 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Acot3 34
  • 83.37 (n)
  • 78.38 (a)
cow
(Bos Taurus)
Mammalia ACOT2 35
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 43 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ACOT2 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-288i20.1 34
  • 53.83 (n)
  • 46.67 (a)
si:dkey-288i20.1 35
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C31H5.6 35
  • 25 (a)
ManyToMany
K05B2.4 35
  • 28 (a)
ManyToMany
T05E7.1 35
  • 22 (a)
ManyToMany
W03D8.8 35
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for ACOT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT1 Gene

ENSEMBL:
Gene Tree for ACOT1 (if available)
TreeFam:
Gene Tree for ACOT1 (if available)

Paralogs for ACOT1 Gene

Paralogs for ACOT1 Gene

(4) SIMAP similar genes for ACOT1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ACOT1 Gene

genes like me logo Genes that share paralogs with ACOT1: view

Variants for ACOT1 Gene

Sequence variations from dbSNP and Humsavar for ACOT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_059830 -

Structural Variations from Database of Genomic Variants (DGV) for ACOT1 Gene

Variant ID Type Subtype PubMed ID
dgv1102n106 CNV deletion 24896259
dgv1935n100 CNV gain 25217958
dgv21n47 CNV loss 21111241
dgv375n67 CNV loss 20364138
dgv3761n54 CNV gain 21841781
dgv3763n54 CNV loss 21841781
dgv3764n54 CNV gain 21841781
dgv3765n54 CNV gain 21841781
dgv3766n54 CNV gain 21841781
dgv3767n54 CNV loss 21841781
dgv3768n54 CNV loss 21841781
dgv3769n54 CNV loss 21841781
dgv3770n54 CNV loss 21841781
dgv3771n54 CNV loss 21841781
dgv3772n54 CNV loss 21841781
dgv3773n54 CNV gain 21841781
dgv401e199 CNV deletion 23128226
dgv653e212 CNV gain 25503493
dgv654e212 CNV loss 25503493
dgv655e212 CNV gain 25503493
dgv656e212 CNV gain 25503493
dgv657e212 CNV gain 25503493
dgv658e212 CNV gain 25503493
dgv659e212 CNV gain 25503493
dgv660e212 CNV loss 25503493
dgv661e212 CNV loss 25503493
esv1006342 CNV deletion 20482838
esv2421969 OTHER complex 20811451
esv2518446 CNV loss 19546169
esv2672436 CNV deletion 23128226
esv2748867 CNV deletion 23290073
esv2759996 CNV gain 17122850
esv2760335 CNV gain+loss 21179565
esv2761566 CNV gain+loss 21179565
esv2904901 CNV deletion 24192839
esv29080 CNV gain+loss 19812545
esv29945 CNV loss 18421352
esv33155 CNV gain+loss 17666407
esv3423432 CNV duplication 20981092
esv3581298 CNV loss 25503493
esv3581301 CNV loss 25503493
esv3584669 CNV loss 24956385
esv3634909 CNV loss 21293372
esv3892561 CNV gain 25118596
esv990289 CNV loss 20482838
nsv1035460 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv1350 CNV deletion 18451855
nsv428295 CNV gain 18775914
nsv436178 CNV deletion 17901297
nsv442687 CNV loss 18776908
nsv482172 CNV gain 20164927
nsv510643 CNV deletion 20534489
nsv514748 CNV gain 21397061
nsv514749 CNV gain+loss 21397061
nsv565110 CNV loss 21841781
nsv565111 CNV loss 21841781
nsv565124 CNV gain+loss 21841781
nsv565125 CNV gain 21841781
nsv565153 CNV loss 21841781
nsv819138 CNV loss 19587683
nsv821106 CNV deletion 20802225
nsv826976 CNV loss 20364138
nsv826978 CNV loss 20364138
nsv826979 CNV loss 20364138
nsv832828 CNV gain+loss 17160897
nsv9153 CNV gain+loss 18304495
nsv952866 CNV deletion 24416366

Variation tolerance for ACOT1 Gene

Gene Damage Index Score: 4.61; 65.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT1 Gene

Disorders for ACOT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACOT1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ACOT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACOT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT1
genes like me logo Genes that share disorders with ACOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT1 Gene

Publications for ACOT1 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4 65
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3 65
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for ACOT1 Gene

Sources for ACOT1 Gene

Content
Loading form....