Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ACOT1 Gene

protein-coding   GIFtS: 50
GCID: GC14P074003

Acyl-CoA Thioesterase 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Acyl-CoA Thioesterase 11 2 3     EC 3.1.2.23 8
Inducible Cytosolic Acyl-Coenzyme A Thioester Hydrolase2 3     ACH22
Long Chain Acyl-CoA Hydrolase2 3     CTE-12
Long Chain Acyl-CoA Thioester Hydrolase2 3     LACH22
CTE-I2 3     Acyl-Coenzyme A Thioesterase 12
CTE-Ib2 3     CTE13

External Ids:    HGNC: 331281   Entrez Gene: 6413712   Ensembl: ENSG000001842277   OMIM: 6143135   UniProtKB: Q86TX23   

Export aliases for ACOT1 gene to outside databases

Previous GC identifers: GC14U900538 GC14P073074 GC14P054170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ACOT1 Gene:
ACOT1 (acyl-CoA thioesterase 1) is a protein-coding gene. GO annotations related to this gene include and acyl-CoA hydrolase activity. An important paralog of this gene is ACOT6.

UniProtKB/Swiss-Prot: ACOT1_HUMAN, Q86TX2
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACOT1 gene promoter:
         AREB6   PPAR-alpha   PPAR-gamma1   HNF-4alpha2   PPAR-gamma2   Arnt   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACOT1 promoter sequence
   Search Chromatin IP Primers for ACOT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

ACOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACOT1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P074003:  view genomic region     (about GC identifiers)

Start:
74,003,818 bp from pter      End:
74,010,498 bp from pter
Size:
6,681 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACOT1_HUMAN, Q86TX2 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase 1  
Size: 421 amino acids; 46277 Da
Subunit: Monomer (By similarity)
Secondary accessions: A1L173 Q3I5F9

Explore the universe of human proteins at neXtProt for ACOT1: NX_Q86TX2

Explore proteomics data for ACOT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys286
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACOT1 (Q86TX2) (see all 10)
     DDHNWKS  WKSEFYA  IEPPYFP  PALGGSF 


    See ACOT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001032238.1  
    ENSEMBL proteins: 
     ENSP00000311224   ENSP00000451764  

    ACOT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACOT1
    OriGene Protein Over-expression Lysate for ACOT1
    OriGene MassSpec for ACOT1
    OriGene Custom Protein Services for ACOT1
    GenScript Custom Purified and Recombinant Proteins Services for ACOT1
    Novus Biologicals ACOT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACOT1

     
    Search eBioscience for Proteins for ACOT1 

    ACOT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACOT1
    OriGene Custom Antibody Services for ACOT1
    Novus Biologicals ACOT1 Antibody
    Abcam antibodies for ACOT1
    Cloud-Clone Corp. Antibodies for ACOT1
    Search ThermoFisher Antibodies for ACOT1
    LSBio Antibodies in human, mouse, rat for ACOT1

    ACOT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACOT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACOT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACOT1
    Cloud-Clone Corp. CLIAs for ACOT1
    Search eBioscience for ELISAs for ACOT1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ACOT: Acyl CoA thioesterases

    3 InterPro protein domains:
     IPR006862 Thio_Ohase/aa_AcTrfase
     IPR014940 BAAT_C
     IPR016662 Acyl-CoA_thioEstase_long-chain

    Graphical View of Domain Structure for InterPro Entry Q86TX2

    ProtoNet protein and cluster: Q86TX2

    1 Blocks protein domain: IPB006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

    UniProtKB/Swiss-Prot: ACOT1_HUMAN, Q86TX2
    Similarity: Belongs to the C/M/P thioester hydrolase family


    Find genes that share domains with ACOT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACOT1_HUMAN, Q86TX2
    Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free
    fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free
    fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity)
    Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate
    Biophysicochemical properties: Kinetic parameters: KM=35.8 uM for C10-acyl-CoA; KM=3.6 uM for C12-acyl-CoA; KM=2.8
    uM for C14-acyl-CoA; KM=3.6 uM for C16-acyl-CoA; KM=2.4 uM for C18-acyl-CoA; KM=2 uM for C20-acyl-CoA; KM=2.4 uM
    for C16:1-acyl-CoA; KM=4.1 uM for C18:1-acyl-CoA; KM=2.1 uM for C18:1-trans-acyl-CoA; Vmax=224 nmol/min/mg enzyme
    toward C10-acyl-CoA; Vmax=700 nmol/min/mg enzyme toward C12-acyl-CoA; Vmax=912 nmol/min/mg enzyme toward
    C14-acyl-CoA; Vmax=691 nmol/min/mg enzyme toward C16-acyl-CoA; Vmax=597 nmol/min/mg enzyme toward C18-acyl-CoA;
    Vmax=520 nmol/min/mg enzyme toward C20-acyl-CoA; Vmax=577 nmol/min/mg enzyme toward C16:1-acyl-CoA; Vmax=258
    nmol/min/mg enzyme toward C18:1-acyl-CoA; Vmax=309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA;

         Enzyme Number (IUBMB): EC 3.1.2.21 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016290palmitoyl-CoA hydrolase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0016790thiolester hydrolase activity ----
    GO:0047617acyl-CoA hydrolase activity IDA16940157
         
    Find genes that share ontologies with ACOT1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACOT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACOT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACOT1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ACOT1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ACOT1
    SwitchGear 3'UTR luciferase reporter plasmidACOT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACOT1
    Predesigned siRNA for gene silencing in human, mouse, rat ACOT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACOT1

    Clone
    Products:
         
    OriGene clones in human, mouse for ACOT1 (see all 7)
    OriGene ORF clones in mouse, rat for ACOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACOT1 (NM_015547)
    Sino Biological Human cDNA Clone for ACOT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACOT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACOT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ACOT1_HUMAN, Q86TX2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion4
    nucleus2
    peroxisome2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005829cytosol IDA16940157

    Find genes that share ontologies with ACOT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ACOT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    oleate biosynthesis II (animals)0.32
    Fatty acid elongation0.38
    2Metabolism
    Metabolic pathways0.38
    3stearate biosynthesis I (animals)
    stearate biosynthesis I (animals)0.35
    4palmitate biosynthesis I (animals)
    palmitate biosynthesis I (animals)


    Find genes that share SuperPaths with ACOT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ACOT1
        stearate biosynthesis I (animals)
    oleate biosynthesis II (animals)
    palmitate biosynthesis I (animals)



    3 Kegg Pathways  (Kegg details for ACOT1):
        Fatty acid elongation
    Biosynthesis of unsaturated fatty acids
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT1: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ACOT1

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000038very long-chain fatty acid metabolic process IDA16940157
    GO:0001676long-chain fatty acid metabolic process IDA16940157
    GO:0006637acyl-CoA metabolic process IDA16940157

    Find genes that share ontologies with ACOT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACOT1

    Selected HMDB Compounds for ACOT1 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    11'-Carboxy-alpha-chromanol2,5,7,8-Tetramethyl-2-(4',8'-dimethyl-11'-carboxy-undecyl)-6-chromanol;RRR-11'-carboxy-alpha-chromanol;2-(11-carboxy-4,8-dimethylundecyl)-6-hydroxy-2,5,7,8-tetramethylchroman;11'-carboxy-alpha-tocopherol ----
    11'-Carboxy-alpha-tocotrienolalpha-CDMD(en)(2)HC;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,5,7,8-tetramethylchroman;alpha-CDMD(en)(,2)HC ----
    11'-Carboxy-gama-chromanol2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-chromanol;2,7,8-trimethyl-2-(11'-carboxy-4',8'-dimethylundecyl)-6-hydroxychroman;RRR-11'-carboxy-gama-chromanol;11'-Carboxy-gama-tocopherol ----
    11'-carboxy-gama-tocotrienolgama-CDMD(en)(2)HC;carboxydimethyldecadienyl hydroxychroman;2-(10-carboxy-4,8-dimethyl-(3E,7E)-decadienyl)-6-hydroxy-2,7,8-trimethylchroman ----
    13'-carboxy-alpha-tocotrienol13AaTE ----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ACOT1 gene: 
    NM_001037161.1  

    Unigene Cluster for ACOT1:

    Acyl-CoA thioesterase 1
    Hs.568046  [show with all ESTs]
    Unigene Representative Sequence: BX161396
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311148(uc001xol.1 uc010tuc.2) ENST00000557556
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACOT1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ACOT1
    SwitchGear 3'UTR luciferase reporter plasmidACOT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACOT1
    Predesigned siRNA for gene silencing in human, mouse, rat ACOT1
    Clone
    Products:
         
    OriGene clones in human, mouse for ACOT1 (see all 7)
    OriGene ORF clones in mouse, rat for ACOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACOT1 (NM_015547)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACOT1
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACOT1
      Search QuantiTect SYBR Green Assays in human, mouse, rat ACOT1
      QuantiFast Probe-based Assays in human, mouse, rat ACOT1

    Additional mRNA sequence: 

    AK300886.1 BC127747.1 BC127748.1 BC132889.1 BC132891.1 BC143042.1 BX161396.1 DQ082754.1 
    GU727640.1 

    9 DOTS entries:

    DT.100824510  DT.445656  DT.95157623  DT.100824506  DT.91760359  DT.97813369  DT.100824503  DT.100824511 
    DT.86853383 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ACOT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ACOT1 Expression
    About this image


    ACOT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    ACOT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACOT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.568046
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACOT1: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACOT1
    OriGene qSTAR qPCR primer pairs in human, mouse for ACOT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACOT1
    Search QuantiTect SYBR Green Assays in human, mouse, rat ACOT1
    QuantiFast Probe-based Assays in human, mouse, rat ACOT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ACOT1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acot31 , 5 acyl-CoA thioesterase 31, 5 82.5(n)1
    76.72(a)1
      12 (39.02 cM)5
    1712811  NM_134246.31  NP_599007.11 
     840521445 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    61(a)
    1 → many
    5(25464271-25468294)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    1 → many
    1(39211695-39218982)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-288i20.11 si:dkey-288i20.1 53.83(n)
    46.67(a)
      553217  NM_001256219.1  NP_001243148.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K05B2.46
    W03D8.86
    (see all 4)
    Protein W03D8.8 (W03D8.8) mRNA, complete cds
    (see all 4)
    28(a)
    27(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(4919020-4920988) WBGene00019404
    I(2791689-2794895) WBGene00020989


    ENSEMBL Gene Tree for ACOT1 (if available)
    TreeFam Gene Tree for ACOT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ACOT1 gene
    ACOT62  ACOT42  ACOT22  BAAT2  
    4 SIMAP similar genes for ACOT1 using alignment to 3 protein entries:     ACOT1_HUMAN (see all proteins):
    ACOT2    ACOT4    ACOT6    BAAT

    Find genes that share paralogs with ACOT1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ACOT1
    PGOHUM00000258798 PGOHUM00000256743


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    6 SNPs for ACOT1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500642841,2
    C--74002167(+) TTTTC-/TTCTTT
    CTTTTTTTT
    TTTTT
    1 -- us2k10--------
    rs105341041,2
    C--74003681(+) GCCTG-/GTTGTTGT 1 -- us2k10--------
    rs2003541911,2
    --74003688(+) TGTTG-/TTGT  
            
    TTTTT
    1 -- us2k10--------
    rs2017492691,2
    --74003689(+) GTTGT-/TGTTTTT 1 -- us2k10--------
    rs10495681,2,4
    ----see VAR_0598302 mis40--------
    rs716769311,2
    ----74002169(+) ttctt-/CTttctt 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACOT1 (74003818 - 74010498 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ACOT1 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821106CNV Deletion20802225
    esv2672436CNV Deletion23128226
    esv2748867CNV Deletion23290073
    nsv436178CNV Deletion17901297
    dgv401e199CNV Deletion23128226
    esv1006342CNV Deletion20482838
    nsv826978CNV Loss20364138
    nsv826979CNV Loss20364138
    esv990289CNV Loss20482838
    esv29945CNV Loss18421352

    1 Site Specific Mutation Identification with PCR Assay for ACOT1:
    Cosmic IdAA Change
    98000001
    SeqTarget long-range PCR primers for resequencing ACOT1
    DNA2.0 Custom Variant and Variant Library Synthesis for ACOT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614313    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ACOT1:
    Human immunodeficiency virus infectious disease

    Find genes that share disorders with ACOT1           About GenesLikeMe


    Export disorders for ACOT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ACOT1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ACOT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PubMed id 16940157)1, 2, 3 Hunt M.C.... Alexson S.E.H. (FASEB J. 2006)
    2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PubMed id 16103133)1, 3 Hunt M.C....Alexson S.E. (J. Lipid Res. 2005)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1 Li J.... Liu Y. (Mol. Cell. Proteomics 2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 641371 HGNC: 33128 Ensembl:ENSG00000184227 euGenes: HUgn641371 ECgene: ACOT1 Kegg: 641371
    H-InvDB: ACOT1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ACOT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ACOT1 gene:
    Search GeneIP for patents involving ACOT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACOT1   OriGene RNAi products in human, mouse, rat for ACOT1  
     OriGene qPCR primer pairs and template standards for ACOT1   OriGene Protein Over-expression Lysate for ACOT1  
     OriGene MassSpec something-or-other for ACOT1   OriGene clones in human, mouse for ACOT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACOT1   OriGene Purified Protein for ACOT1  
     OriGene ORF clones in mouse, rat for ACOT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACOT1   OriGene Custom Protein Services for ACOT1  

     
     
     Block miRNA regulation of human, mouse, rat ACOT1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ACOT1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACOT1 Predesigned siRNA for gene silencing in human, mouse, rat ACOT1
     QuantiFast Probe-based Assays in human, mouse, rat ACOT1 Search QuantiTect SYBR Green Assays in human, mouse, rat ACOT1
     PCR Arrays including human, mouse, rat ACOT1 Search Chromatin IP Primers for ACOT1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACOT1  Search GeneGlobe Interaction Network for ACOT1
     Regulatory tfbs in ACOT1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ACOT1 GenScript cDNA clones with any tag delivered in your preferred vector for ACOT1
     GenScript Custom Assay Services for ACOT1 GenScript Custom overexpressing Cell Line Services for ACOT1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ACOT1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ACOT1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ACOT1 antibodies
     ACOT1 lysates
     Antibodies for ACOT1
     See all of Abcam's Antibodies, Kits and Proteins for ACOT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ACOT1
     Antibodies for ACOT1
     ELISAs for ACOT1
     CLIAs for ACOT1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ACOT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACOT1
     SwitchGear 3'UTR luciferase reporter plasmids for ACOT1
     SwitchGear Promoter luciferase reporter plasmids for ACOT1
     Search ThermoFisher Antibodies for ACOT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACOT1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACOT1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACOT1
     LSBio Antibodies in human, mouse, rat for ACOT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ACOT1
      Search eBioscience for proteins for ACOT1
      Search eBioscience for elisas for ACOT1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACOT1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4