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Aliases for ACOT1 Gene

Aliases for ACOT1 Gene

  • Acyl-CoA Thioesterase 1 2 3 4 5
  • Inducible Cytosolic Acyl-Coenzyme A Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Hydrolase 3 4
  • EC 4 58
  • CTE-Ib 3 4
  • CTE-I 3 4
  • Acyl-Coenzyme A Thioesterase 1 3
  • CTE-1 3
  • LACH2 3
  • ACH2 3
  • CTE1 4

External Ids for ACOT1 Gene

Previous GeneCards Identifiers for ACOT1 Gene

  • GC14U900538
  • GC14P073074
  • GC14P074003
  • GC14P054170
  • GC14P073537

Summaries for ACOT1 Gene

GeneCards Summary for ACOT1 Gene

ACOT1 (Acyl-CoA Thioesterase 1) is a Protein Coding gene. Diseases associated with ACOT1 include Retinitis Pigmentosa 67 and Spindle Cell Hemangioma. Among its related pathways are oleate biosynthesis and Fatty acid elongation. GO annotations related to this gene include hydrolase activity and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT2.

UniProtKB/Swiss-Prot for ACOT1 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

Additional gene information for ACOT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT1 Gene

Genomics for ACOT1 Gene

Regulatory Elements for ACOT1 Gene

Enhancers for ACOT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H073570 0.7 ENCODE 35.5 +77.7 77718 0.2 CTCF PKNOX1 SAP130 ARID4B SIN3A ZNF384 YBX1 RAD21 YY1 TEAD3 ACOT1 NT5CP1 GC14M073568
GH14H073464 1.6 FANTOM5 ENCODE dbSUPER 12.1 -26.0 -26034 5.4 BMI1 FEZF1 BATF EGR1 FOS ATF7 RUNX3 IKZF2 CREM EGR2 NUMB PSEN1 ACOT1 HEATR4 LOC101928123 ENSG00000258695 DCAF4 ZNF410 ZFYVE1 RBM25
GH14H073567 1.1 ENCODE 16.2 +75.7 75723 3.8 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF207 ACOT1 RBM25 ZNF410 ELMSAN1 ENSG00000258695 ZFYVE1 DCAF4 ENSG00000258559 LOC100506476 ACOT2
GH14H073490 1.1 ENCODE 16 -1.8 -1834 2.5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ACOT1 LOC100420966 ELMSAN1 ZNF410 RBM25 DCAF4 ENSG00000258695 NUMB GC14P073495 PIR46009
GH14H073738 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.5 +250.0 250036 9.8 PKNOX1 ZNF133 ARID4B SIN3A ZBTB7B TCF12 SLC30A9 GLIS2 GATA2 FOS PNMA1 LOC100506476 PTGR2 ENSG00000223300 ELMSAN1 ACOT1 ZNF410 GC14P073756
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACOT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ACOT1 Gene

Genomic Locations for ACOT1 Gene
50,566 bases
Plus strand

Genomic View for ACOT1 Gene

Genes around ACOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT1 Gene

Proteins for ACOT1 Gene

  • Protein details for ACOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A thioesterase 1
    Protein Accession:
    Secondary Accessions:
    • A1L173
    • Q3I5F9

    Protein attributes for ACOT1 Gene

    421 amino acids
    Molecular mass:
    46277 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for ACOT1 Gene

Selected DME Specific Peptides for ACOT1 Gene


Post-translational modifications for ACOT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT1 Gene

Domains & Families for ACOT1 Gene

Gene Families for ACOT1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACOT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the C/M/P thioester hydrolase family.
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT1: view

Function for ACOT1 Gene

Molecular function for ACOT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=35.8 uM for C10-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C12-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.8 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C16-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C18-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2 uM for C20-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.1 uM for C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.1 uM for C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=224 nmol/min/mg enzyme toward C10-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=700 nmol/min/mg enzyme toward C12-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=912 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=691 nmol/min/mg enzyme toward C16-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=597 nmol/min/mg enzyme toward C18-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=520 nmol/min/mg enzyme toward C20-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=577 nmol/min/mg enzyme toward C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=258 nmol/min/mg enzyme toward C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate.
UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

Enzyme Numbers (IUBMB) for ACOT1 Gene

Phenotypes From GWAS Catalog for ACOT1 Gene

Gene Ontology (GO) - Molecular Function for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS,IDA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT1: view

Phenotypes for ACOT1 Gene

GenomeRNAi human phenotypes for ACOT1:
genes like me logo Genes that share phenotypes with ACOT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACOT1 Gene

Localization for ACOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT1 gene
Compartment Confidence
cytosol 5
peroxisome 3
mitochondrion 2
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with ACOT1: view

Pathways & Interactions for ACOT1 Gene

genes like me logo Genes that share pathways with ACOT1: view

Gene Ontology (GO) - Biological Process for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process TAS,IEA --
genes like me logo Genes that share ontologies with ACOT1: view

No data available for SIGNOR curated interactions for ACOT1 Gene

Drugs & Compounds for ACOT1 Gene

(13) Drugs for ACOT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Gamma-Homolinolenic acid Approved Nutra 0
Icosapent Approved Nutra 0

(41) Additional Compounds for ACOT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with ACOT1: view

Transcripts for ACOT1 Gene

mRNA/cDNA for ACOT1 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT1 Gene

Acyl-CoA thioesterase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT1 Gene

No ASD Table

Relevant External Links for ACOT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACOT1 Gene

This gene is overexpressed in Nasopharynx (14.1) and Skin (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACOT1 Gene

Protein tissue co-expression partners for ACOT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACOT1 Gene:


SOURCE GeneReport for Unigene cluster for ACOT1 Gene:


Evidence on tissue expression from TISSUES for ACOT1 Gene

  • Heart(2.3)
  • Liver(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ACOT1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOT1 Gene

Orthologs for ACOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACOT2 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Acot3 33
  • 83.37 (n)
(Mus musculus)
Mammalia Acot3 33 16 34
  • 82.5 (n)
Acot1 34
  • 77 (a)
Acot5 34
  • 74 (a)
Acot2 34
  • 71 (a)
(Canis familiaris)
Mammalia -- 34
  • 77 (a)
(Bos Taurus)
Mammalia ACOT2 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
-- 34
  • 59 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
(Gallus gallus)
Aves -- 34
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 61 (a)
(Danio rerio)
Actinopterygii si:dkey-288i20.1 34 33
  • 53.83 (n)
(Caenorhabditis elegans)
Secernentea K05B2.4 34
  • 28 (a)
W03D8.8 34
  • 27 (a)
C31H5.6 34
  • 25 (a)
T05E7.1 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
-- 34
  • 35 (a)
-- 34
  • 35 (a)
-- 34
  • 35 (a)
-- 34
  • 34 (a)
-- 34
  • 33 (a)
-- 34
  • 31 (a)
-- 34
  • 30 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
Species where no ortholog for ACOT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT1 Gene

Gene Tree for ACOT1 (if available)
Gene Tree for ACOT1 (if available)

Paralogs for ACOT1 Gene

Paralogs for ACOT1 Gene

(4) SIMAP similar genes for ACOT1 Gene using alignment to 3 proteins: Pseudogenes for ACOT1 Gene

genes like me logo Genes that share paralogs with ACOT1: view

Variants for ACOT1 Gene

Sequence variations from dbSNP and Humsavar for ACOT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1057519450 Pathogenic 73,537,831(+) GCGCG(-/AGCCGGTGCGCGCG)GGCCG intron-variant, reference, frameshift-variant
rs1000028636 -- 73,517,976(+) AGCTA(C/T)TCGTG intron-variant
rs1000042399 -- 73,496,632(+) CTTGG(C/T)TTCCT intron-variant, reference, missense
rs1000135040 -- 73,524,860(+) TGTCC(A/G)AGGTG intron-variant
rs1000190326 -- 73,543,268(+) ATTGT(A/G)GATGT intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ACOT1 Gene

Variant ID Type Subtype PubMed ID
dgv1102n106 CNV deletion 24896259
dgv1935n100 CNV gain 25217958
dgv21n47 CNV loss 21111241
dgv375n67 CNV loss 20364138
dgv3761n54 CNV gain 21841781
dgv3763n54 CNV loss 21841781
dgv3764n54 CNV gain 21841781
dgv3765n54 CNV gain 21841781
dgv3766n54 CNV gain 21841781
dgv3767n54 CNV loss 21841781
dgv3768n54 CNV loss 21841781
dgv3769n54 CNV loss 21841781
dgv3770n54 CNV loss 21841781
dgv3771n54 CNV loss 21841781
dgv3772n54 CNV loss 21841781
dgv3773n54 CNV gain 21841781
dgv401e199 CNV deletion 23128226
dgv653e212 CNV gain 25503493
dgv654e212 CNV loss 25503493
dgv655e212 CNV gain 25503493
dgv656e212 CNV gain 25503493
dgv657e212 CNV gain 25503493
dgv658e212 CNV gain 25503493
dgv659e212 CNV gain 25503493
dgv660e212 CNV loss 25503493
dgv661e212 CNV loss 25503493
esv1006342 CNV deletion 20482838
esv2421969 OTHER complex 20811451
esv2518446 CNV loss 19546169
esv2672436 CNV deletion 23128226
esv2748867 CNV deletion 23290073
esv2759996 CNV gain 17122850
esv2760335 CNV gain+loss 21179565
esv2761566 CNV gain+loss 21179565
esv2904901 CNV deletion 24192839
esv29080 CNV gain+loss 19812545
esv29945 CNV loss 18421352
esv33155 CNV gain+loss 17666407
esv3423432 CNV duplication 20981092
esv3581298 CNV loss 25503493
esv3581301 CNV loss 25503493
nsv952866 CNV deletion 24416366
nsv9153 CNV gain+loss 18304495
nsv832828 CNV gain+loss 17160897
nsv826979 CNV loss 20364138
nsv826978 CNV loss 20364138
nsv826976 CNV loss 20364138
nsv821106 CNV deletion 20802225
nsv819138 CNV loss 19587683
nsv565153 CNV loss 21841781
nsv565125 CNV gain 21841781
nsv565124 CNV gain+loss 21841781
nsv565111 CNV loss 21841781
nsv565110 CNV loss 21841781
nsv514749 CNV gain+loss 21397061
nsv514748 CNV gain 21397061
nsv510643 CNV deletion 20534489
nsv482172 CNV gain 20164927
nsv442687 CNV loss 18776908
nsv436178 CNV deletion 17901297
nsv428295 CNV gain 18775914
nsv1350 CNV deletion 18451855
nsv1053281 CNV gain 25217958
nsv1035460 CNV gain 25217958
esv990289 CNV loss 20482838
esv3892561 CNV gain 25118596
esv3634909 CNV loss 21293372
esv3584669 CNV loss 24956385

Variation tolerance for ACOT1 Gene

Gene Damage Index Score: 4.61; 65.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT1 Gene

Disorders for ACOT1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ACOT1 Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ACOT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACOT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ACOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT1 Gene

Publications for ACOT1 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt MC … Alexson SE (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 4 60
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt MC … Alexson SE (Journal of lipid research 2005) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ACOT1 Gene

Sources for ACOT1 Gene

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