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Aliases for ACOT1 Gene

Aliases for ACOT1 Gene

  • Acyl-CoA Thioesterase 1 2 3 4
  • Inducible Cytosolic Acyl-Coenzyme A Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Hydrolase 3 4
  • EC 3.1.2.2 4 64
  • CTE-Ib 3 4
  • CTE-I 3 4
  • Acyl-Coenzyme A Thioesterase 1 3
  • CTE-1 3
  • LACH2 3
  • ACH2 3
  • CTE1 4

External Ids for ACOT1 Gene

Summaries for ACOT1 Gene

GeneCards Summary for ACOT1 Gene

ACOT1 (Acyl-CoA Thioesterase 1) is a Protein Coding gene. Among its related pathways are Metabolism and stearate biosynthesis I (animals). GO annotations related to this gene include acyl-CoA hydrolase activity. An important paralog of this gene is ACOT2.

UniProtKB/Swiss-Prot for ACOT1 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT1 Gene

Genomics for ACOT1 Gene

Genomic Location for ACOT1 Gene

Start:
73,537,114 bp from pter
End:
73,543,794 bp from pter
Size:
6,681 bases
Orientation:
Plus strand

Genomic View for ACOT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT1 Gene

Regulatory Elements for ACOT1 Gene

Proteins for ACOT1 Gene

  • Protein details for ACOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TX2-ACOT1_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 1
    Protein Accession:
    Q86TX2
    Secondary Accessions:
    • A1L173
    • Q3I5F9

    Protein attributes for ACOT1 Gene

    Size:
    421 amino acids
    Molecular mass:
    46277 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for ACOT1 Gene

Proteomics data for ACOT1 Gene at MOPED

Post-translational modifications for ACOT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys286

Other Protein References for ACOT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ACOT1 Gene

Gene Families for ACOT1 Gene

HGNC:
  • ACOT :Acyl CoA thioesterases

UniProtKB/Swiss-Prot:

ACOT1_HUMAN
Family:
  • Belongs to the C/M/P thioester hydrolase family.:
    • Q86TX2
genes like me logo Genes that share domains with ACOT1: view

Function for ACOT1 Gene

Molecular function for ACOT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=35.8 uM for C10-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C12-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.8 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C16-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C18-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2 uM for C20-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.1 uM for C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.1 uM for C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=224 nmol/min/mg enzyme toward C10-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=700 nmol/min/mg enzyme toward C12-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=912 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=691 nmol/min/mg enzyme toward C16-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=597 nmol/min/mg enzyme toward C18-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=520 nmol/min/mg enzyme toward C20-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=577 nmol/min/mg enzyme toward C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=258 nmol/min/mg enzyme toward C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity: Palmitoyl-CoA + H(2)O = CoA + palmitate
UniProtKB/Swiss-Prot Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

Enzyme Numbers (IUBMB) for ACOT1 Gene

Gene Ontology (GO) - Molecular Function for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0016787 hydrolase activity --
GO:0016790 thiolester hydrolase activity --
GO:0047617 acyl-CoA hydrolase activity IDA 16940157
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACOT1 Gene

Localization for ACOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT1 Gene COMPARTMENTS Subcellular localization image for ACOT1 gene
Compartment Confidence
cytosol 4
mitochondrion 4
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16940157
genes like me logo Genes that share ontologies with ACOT1: view

Pathways for ACOT1 Gene

genes like me logo Genes that share pathways with ACOT1: view

Interacting Proteins for ACOT1 Gene

Gene Ontology (GO) - Biological Process for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process IDA 16940157
genes like me logo Genes that share ontologies with ACOT1: view

Compounds for ACOT1 Gene

(49) HMDB Compounds for ACOT1 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT1: view

Transcripts for ACOT1 Gene

mRNA/cDNA for ACOT1 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT1 Gene

Acyl-CoA thioesterase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT1 Gene

No ASD Table

Relevant External Links for ACOT1 Gene

GeneLoc Exon Structure for
ACOT1
ECgene alternative splicing isoforms for
ACOT1

Expression for ACOT1 Gene

mRNA expression in normal human tissues for ACOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOT1 Gene

SOURCE GeneReport for Unigene cluster for ACOT1 Gene Hs.568046

genes like me logo Genes that share expressions with ACOT1: view

Orthologs for ACOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT2 37
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACOT2 37
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Acot1 37
  • 77 (a)
ManyToMany
Acot2 37
  • 71 (a)
ManyToMany
Acot3 36
  • 82.5 (n)
  • 76.72 (a)
Acot3 16
Acot3 37
  • 75 (a)
ManyToMany
Acot5 37
  • 74 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 43 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Acot3 36
  • 83.37 (n)
  • 78.38 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-288i20.1 36
  • 53.83 (n)
  • 46.67 (a)
si:dkey-288i20.1 37
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C31H5.6 37
  • 25 (a)
ManyToMany
K05B2.4 37
  • 28 (a)
ManyToMany
T05E7.1 37
  • 22 (a)
ManyToMany
W03D8.8 37
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
Species with no ortholog for ACOT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT1 Gene

ENSEMBL:
Gene Tree for ACOT1 (if available)
TreeFam:
Gene Tree for ACOT1 (if available)

Paralogs for ACOT1 Gene

Paralogs for ACOT1 Gene

Selected SIMAP similar genes for ACOT1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ACOT1 Gene

genes like me logo Genes that share paralogs with ACOT1: view

Variants for ACOT1 Gene

Sequence variations from dbSNP and Humsavar for ACOT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_059830 -

Structural Variations from Database of Genomic Variants (DGV) for ACOT1 Gene

Variant ID Type Subtype PubMed ID
dgv1958n71 CNV Gain 21882294
nsv510643 CNV Loss 20534489
dgv641e1 CNV Complex 17122850
nsv428295 CNV Gain 18775914
nsv832828 CNV Gain+Loss 17160897
nsv1350 CNV Loss 18451855
nsv9153 CNV Gain+Loss 18304495
nsv821106 CNV Deletion 20802225
nsv826976 CNV Loss 20364138
esv29080 CNV Gain+Loss 19812545
esv1006342 CNV Deletion 20482838
dgv401e199 CNV Deletion 23128226
nsv819138 CNV Loss 19587683
dgv21n47 CNV Loss 21111241
esv2748867 CNV Deletion 23290073
esv2518446 CNV Loss 19546169
esv2421969 OTHER Complex 20811451
nsv902088 CNV Gain 21882294
nsv442687 CNV CNV 18776908
nsv826978 CNV Loss 20364138
nsv826979 CNV Loss 20364138
esv990289 CNV Loss 20482838
esv29945 CNV Loss 18421352
esv33155 CNV Gain+Loss 17666407
nsv482172 CNV Gain 20164927
dgv375n67 CNV Loss 20364138
nsv436178 CNV Deletion 17901297
esv2672436 CNV Deletion 23128226
nsv514748 CNV Complex 21397061
nsv514749 CNV Complex 21397061

Relevant External Links for ACOT1 Gene

HapMap Linkage Disequilibrium report
ACOT1

Disorders for ACOT1 Gene

(1) University of Copenhagen DISEASES for ACOT1 Gene

genes like me logo Genes that share disorders with ACOT1: view

No data available for UniProtKB/Swiss-Prot for ACOT1 Gene

Publications for ACOT1 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 3 4
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 3
  3. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PMID: 10944470) Jones J.M. … Gould S.J. (Biochem. Biophys. Res. Commun. 2000) 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ACOT1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ACOT1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ACOT1
    • Block miRNA regulation of ACOT1 using miScript Target Protectors

    Sources for ACOT1 Gene

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