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Aliases for ACOT1 Gene

Aliases for ACOT1 Gene

  • Acyl-CoA Thioesterase 1 2 3 4
  • Inducible Cytosolic Acyl-Coenzyme A Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Hydrolase 3 4
  • EC 3.1.2.2 4 63
  • CTE-Ib 3 4
  • CTE-I 3 4
  • CTE-1 3
  • LACH2 3
  • ACH2 3
  • CTE1 4

External Ids for ACOT1 Gene

Previous GeneCards Identifiers for ACOT1 Gene

  • GC14U900538
  • GC14P073074
  • GC14P074003
  • GC14P054170
  • GC14P073537

Summaries for ACOT1 Gene

GeneCards Summary for ACOT1 Gene

ACOT1 (Acyl-CoA Thioesterase 1) is a Protein Coding gene. Diseases associated with ACOT1 include human immunodeficiency virus infectious disease. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include hydrolase activity and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT2.

UniProtKB/Swiss-Prot for ACOT1 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT1 Gene

Genomics for ACOT1 Gene

Regulatory Elements for ACOT1 Gene

Genomic Location for ACOT1 Gene

Chromosome:
14
Start:
73,493,234 bp from pter
End:
73,543,799 bp from pter
Size:
50,566 bases
Orientation:
Plus strand

Genomic View for ACOT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT1 Gene

Proteins for ACOT1 Gene

  • Protein details for ACOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TX2-ACOT1_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 1
    Protein Accession:
    Q86TX2
    Secondary Accessions:
    • A1L173
    • Q3I5F9

    Protein attributes for ACOT1 Gene

    Size:
    421 amino acids
    Molecular mass:
    46277 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for ACOT1 Gene

Proteomics data for ACOT1 Gene at MOPED

Post-translational modifications for ACOT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACOT1 Gene

Gene Families for ACOT1 Gene

Suggested Antigen Peptide Sequences for ACOT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86TX2

UniProtKB/Swiss-Prot:

ACOT1_HUMAN :
  • Belongs to the C/M/P thioester hydrolase family.
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT1: view

Function for ACOT1 Gene

Molecular function for ACOT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=35.8 uM for C10-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C12-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.8 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C16-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C18-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2 uM for C20-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.1 uM for C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.1 uM for C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=224 nmol/min/mg enzyme toward C10-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=700 nmol/min/mg enzyme toward C12-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=912 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=691 nmol/min/mg enzyme toward C16-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=597 nmol/min/mg enzyme toward C18-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=520 nmol/min/mg enzyme toward C20-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=577 nmol/min/mg enzyme toward C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=258 nmol/min/mg enzyme toward C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157};
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate
UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).

Enzyme Numbers (IUBMB) for ACOT1 Gene

Gene Ontology (GO) - Molecular Function for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity --
GO:0047617 acyl-CoA hydrolase activity IDA 16940157
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT1: view

Phenotypes for ACOT1 Gene

GenomeRNAi human phenotypes for ACOT1:
genes like me logo Genes that share phenotypes with ACOT1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACOT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACOT1 Gene

Localization for ACOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACOT1 Gene COMPARTMENTS Subcellular localization image for ACOT1 gene
Compartment Confidence
cytosol 4
mitochondrion 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACOT1: view

Pathways & Interactions for ACOT1 Gene

genes like me logo Genes that share pathways with ACOT1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ACOT1 Gene

Gene Ontology (GO) - Biological Process for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006637 acyl-CoA metabolic process IDA 16940157
GO:0019432 triglyceride biosynthetic process TAS --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with ACOT1: view

No data available for SIGNOR curated interactions for ACOT1 Gene

Drugs & Compounds for ACOT1 Gene

(11) Drugs for ACOT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Gamma-Homolinolenic acid Approved Nutra 0
Icosapent Approved Nutra 0
oleic acid Experimental Pharma Activation, Activator 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20

(43) Additional Compounds for ACOT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACOT1: view

Transcripts for ACOT1 Gene

mRNA/cDNA for ACOT1 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT1 Gene

Acyl-CoA thioesterase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACOT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT1 Gene

No ASD Table

Relevant External Links for ACOT1 Gene

GeneLoc Exon Structure for
ACOT1
ECgene alternative splicing isoforms for
ACOT1

Expression for ACOT1 Gene

mRNA expression in normal human tissues for ACOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACOT1 Gene

This gene is overexpressed in Nasopharynx (14.1) and Skin (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACOT1 Gene



SOURCE GeneReport for Unigene cluster for ACOT1 Gene Hs.568046

genes like me logo Genes that share expression patterns with ACOT1: view

Protein tissue co-expression partners for ACOT1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACOT1 Gene

Orthologs for ACOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Acot3 35
  • 82.5 (n)
  • 76.72 (a)
Acot3 16
Acot1 36
  • 77 (a)
ManyToMany
Acot2 36
  • 71 (a)
ManyToMany
Acot3 36
  • 75 (a)
ManyToMany
Acot5 36
  • 74 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Acot3 35
  • 83.37 (n)
  • 78.38 (a)
cow
(Bos Taurus)
Mammalia ACOT2 36
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ACOT2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-288i20.1 35
  • 53.83 (n)
  • 46.67 (a)
si:dkey-288i20.1 36
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C31H5.6 36
  • 25 (a)
ManyToMany
K05B2.4 36
  • 28 (a)
ManyToMany
T05E7.1 36
  • 22 (a)
ManyToMany
W03D8.8 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ACOT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT1 Gene

ENSEMBL:
Gene Tree for ACOT1 (if available)
TreeFam:
Gene Tree for ACOT1 (if available)

Paralogs for ACOT1 Gene

Paralogs for ACOT1 Gene

(4) SIMAP similar genes for ACOT1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ACOT1 Gene

genes like me logo Genes that share paralogs with ACOT1: view

Variants for ACOT1 Gene

Sequence variations from dbSNP and Humsavar for ACOT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_059830 -

Structural Variations from Database of Genomic Variants (DGV) for ACOT1 Gene

Variant ID Type Subtype PubMed ID
dgv1958n71 CNV Gain 21882294
nsv510643 CNV Loss 20534489
dgv641e1 CNV Complex 17122850
nsv428295 CNV Gain 18775914
nsv832828 CNV Gain+Loss 17160897
nsv1350 CNV Loss 18451855
nsv9153 CNV Gain+Loss 18304495
nsv821106 CNV Deletion 20802225
nsv826976 CNV Loss 20364138
esv29080 CNV Gain+Loss 19812545
esv1006342 CNV Deletion 20482838
dgv401e199 CNV Deletion 23128226
nsv819138 CNV Loss 19587683
dgv21n47 CNV Loss 21111241
esv2748867 CNV Deletion 23290073
esv2518446 CNV Loss 19546169
esv2421969 OTHER Complex 20811451
nsv902088 CNV Gain 21882294
nsv442687 CNV CNV 18776908
nsv826978 CNV Loss 20364138
nsv826979 CNV Loss 20364138
esv990289 CNV Loss 20482838
esv29945 CNV Loss 18421352
esv33155 CNV Gain+Loss 17666407
nsv482172 CNV Gain 20164927
dgv375n67 CNV Loss 20364138
nsv436178 CNV Deletion 17901297
esv2672436 CNV Deletion 23128226
nsv514748 CNV Complex 21397061
nsv514749 CNV Complex 21397061

Variation tolerance for ACOT1 Gene

Gene Damage Index Score: 4.61; 65.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOT1 Gene

HapMap Linkage Disequilibrium report
ACOT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT1 Gene

Disorders for ACOT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACOT1 Gene - From: DISEASES

- elite association
Search ACOT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACOT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOT1
genes like me logo Genes that share disorders with ACOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT1 Gene

Publications for ACOT1 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt M.C. … Alexson S.E.H. (FASEB J. 2006) 2 67
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt M.C. … Alexson S.E. (J. Lipid Res. 2005) 2 67
  3. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PMID: 10944470) Jones J.M. … Gould S.J. (Biochem. Biophys. Res. Commun. 2000) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for ACOT1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ACOT1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ACOT1
    • Block miRNA regulation of ACOT1 using miScript Target Protectors

    Sources for ACOT1 Gene

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