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Aliases for ACOD1 Gene

Aliases for ACOD1 Gene

  • Aconitate Decarboxylase 1 2 3 4 5
  • Cis-Aconitic Acid Decarboxylase 3 4
  • IRG1 3 4
  • CAD 3 4
  • Immune-Responsive Gene 1 Protein Homolog 3
  • Immunoresponsive 1 Homolog (Mouse) 2
  • Immune-Responsive Gene 1 Protein 4
  • Cis-Aconitate Decarboxylase 3
  • Immunoresponsive 1 Homolog 3
  • Aconitate Decarboxylase 4
  • EC 4.1.1.6 4

External Ids for ACOD1 Gene

Previous HGNC Symbols for ACOD1 Gene

  • IRG1

Summaries for ACOD1 Gene

GeneCards Summary for ACOD1 Gene

ACOD1 (Aconitate Decarboxylase 1) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism.

UniProtKB/Swiss-Prot for ACOD1 Gene

  • Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOD1 Gene

Genomics for ACOD1 Gene

Regulatory Elements for ACOD1 Gene

Enhancers for ACOD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G076917 1.1 Ensembl ENCODE 11.2 -30.6 -30580 1.2 HDAC1 ATF1 CREB3L1 ARNT NFRKB TCF12 EGR1 RELB IKZF2 CEBPB ACOD1 CLN5 BTF3P11 ENSG00000278727
GH13G076903 0.8 ENCODE 10.1 -44.8 -44756 0.2 CTCF MAX CHD7 RAD21 ZFHX2 GATA2 EED SCRT2 ZNF143 SMC3 ACOD1 ENSG00000278727 BTF3P11
GH13G076976 0.7 ENCODE 10.6 +28.0 27950 0.7 INSM2 FEZF1 GATA3 ZNF366 SCRT2 PRDM10 TCF7L2 ZNF639 ZNF362 ZNF10 ACOD1 GC13M076982
GH13G076974 0.4 FANTOM5 10.9 +25.7 25679 0.2 PKNOX1 ACOD1 GC13M076982
GH13G076831 0.4 ENCODE 9.6 -115.7 -115725 1.7 SMARCA4 EP300 KCTD12 ACOD1 LOC105370265
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACOD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACOD1 Gene

Chromosome:
13
Start:
76,948,497 bp from pter
End:
76,958,659 bp from pter
Size:
10,163 bases
Orientation:
Plus strand

Genomic View for ACOD1 Gene

Genes around ACOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOD1 Gene

Proteins for ACOD1 Gene

  • Protein details for ACOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK06-IRG1_HUMAN
    Recommended name:
    Cis-aconitate decarboxylase
    Protein Accession:
    A6NK06

    Protein attributes for ACOD1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52628 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACOD1 Gene

Post-translational modifications for ACOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACOD1 Gene

Domains & Families for ACOD1 Gene

Protein Domains for ACOD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NK06

UniProtKB/Swiss-Prot:

IRG1_HUMAN :
  • Belongs to the PrpD family.
Family:
  • Belongs to the PrpD family.
genes like me logo Genes that share domains with ACOD1: view

No data available for Gene Families for ACOD1 Gene

Function for ACOD1 Gene

Molecular function for ACOD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cis-aconitate = itaconate + CO(2).
UniProtKB/Swiss-Prot Function:
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
UniProtKB/Swiss-Prot Induction:
Up-regulated after lipopolysaccharide (LPS) stimulation. Up-regulated in LPS-tolerized macrophage by LPS. Up-regulated in peripheral blood mononuclear cells (PBMC) of patient after acute sepsis.

Enzyme Numbers (IUBMB) for ACOD1 Gene

Gene Ontology (GO) - Molecular Function for ACOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016829 lyase activity IEA --
GO:0047547 2-methylcitrate dehydratase activity IBA --
GO:0047613 aconitate decarboxylase activity IEA,IDA 23610393
genes like me logo Genes that share ontologies with ACOD1: view

Phenotypes for ACOD1 Gene

genes like me logo Genes that share phenotypes with ACOD1: view

Animal Models for ACOD1 Gene

MGI Knock Outs for ACOD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACOD1

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for ACOD1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACOD1 Gene

Localization for ACOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOD1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOD1 gene
Compartment Confidence
mitochondrion 5
nucleus 3
peroxisome 2
cytosol 2
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ACOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with ACOD1: view

Pathways & Interactions for ACOD1 Gene

SuperPathways for ACOD1 Gene

SuperPathway Contained pathways
1 Glucose / Energy Metabolism
genes like me logo Genes that share pathways with ACOD1: view

Pathways by source for ACOD1 Gene

1 Cell Signaling Technology pathway for ACOD1 Gene

Interacting Proteins for ACOD1 Gene

Gene Ontology (GO) - Biological Process for ACOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002760 positive regulation of antimicrobial humoral response IDA 23610393
GO:0006952 defense response IDA 23610393
GO:0006954 inflammatory response IEA --
GO:0007566 embryo implantation ISS --
GO:0008152 metabolic process IDA 23610393
genes like me logo Genes that share ontologies with ACOD1: view

No data available for SIGNOR curated interactions for ACOD1 Gene

Drugs & Compounds for ACOD1 Gene

No Compound Related Data Available

Transcripts for ACOD1 Gene

mRNA/cDNA for ACOD1 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for ACOD1

Alternative Splicing Database (ASD) splice patterns (SP) for ACOD1 Gene

No ASD Table

Relevant External Links for ACOD1 Gene

GeneLoc Exon Structure for
ACOD1
ECgene alternative splicing isoforms for
ACOD1

Expression for ACOD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACOD1 Gene:

ACOD1

mRNA Expression by UniProt/SwissProt for ACOD1 Gene:

A6NK06-IRG1_HUMAN
Tissue specificity: Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOD1 Gene

Orthologs for ACOD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRG1 34 35
  • 98.8 (n)
cow
(Bos Taurus)
Mammalia LOC504806 34
  • 85.25 (n)
IRG1 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRG1 34 35
  • 84.37 (n)
rat
(Rattus norvegicus)
Mammalia Irg1 34
  • 83.87 (n)
mouse
(Mus musculus)
Mammalia Irg1 34 35
  • 83.23 (n)
Acod1 16
oppossum
(Monodelphis domestica)
Mammalia IRG1 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRG1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRG1 34 35
  • 66.67 (n)
lizard
(Anolis carolinensis)
Reptilia IRG1 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irg1 34
  • 65.09 (n)
zebrafish
(Danio rerio)
Actinopterygii irg1 34 35
  • 59.29 (n)
Species where no ortholog for ACOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOD1 Gene

ENSEMBL:
Gene Tree for ACOD1 (if available)
TreeFam:
Gene Tree for ACOD1 (if available)

Paralogs for ACOD1 Gene

No data available for Paralogs for ACOD1 Gene

Variants for ACOD1 Gene

Sequence variations from dbSNP and Humsavar for ACOD1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000196345 -- 76,949,381(+) GCAGA(C/T)CAGAA intron-variant
rs1000264365 -- 76,956,233(+) AGTCT(C/T)GCTCT intron-variant
rs1000314429 -- 76,947,934(+) TTTTT(A/T)TTTTT intron-variant, upstream-variant-2KB
rs1000346905 -- 76,948,290(+) TTCTG(A/G)TGCCT intron-variant, upstream-variant-2KB
rs1000496931 -- 76,955,004(+) CACCT(C/G)TTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACOD1 Gene

Variant ID Type Subtype PubMed ID
nsv832651 CNV gain 17160897
nsv832652 CNV gain 17160897
nsv832653 CNV loss 17160897

Variation tolerance for ACOD1 Gene

Gene Damage Index Score: 2.34; 41.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACOD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOD1 Gene

Disorders for ACOD1 Gene

Relevant External Links for ACOD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACOD1

No disorders were found for ACOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOD1 Gene

Publications for ACOD1 Gene

  1. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. (PMID: 23610393) Michelucci A. … Hiller K. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 3 4 64
  2. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through ROS. (PMID: 23609450) Li Y. … Cao X. (J. Biol. Chem. 2013) 3 4 64
  3. Progesterone regulation of the mammalian ortholog of methylcitrate dehydratase (immune response gene 1) in the uterine epithelium during implantation through the protein kinase C pathway. (PMID: 12893884) Chen B. … Pollard J.W. (Mol. Endocrinol. 2003) 2 3 64
  4. Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages. (PMID: 26872335) Tallam A. … Michelucci A. (PLoS ONE 2016) 3 64
  5. Suppression of IRG-1 Reduces Inflammatory Cell Infiltration and Lung Injury in Respiratory Syncytial Virus Infection by Reducing Production of Reactive Oxygen Species. (PMID: 27252532) Ren K. … Li E. (J. Virol. 2016) 3 64

Products for ACOD1 Gene

Sources for ACOD1 Gene

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