Aliases for ACOD1 Gene
External Ids for ACOD1 Gene
Previous HGNC Symbols for ACOD1 Gene
GeneCards Summary for ACOD1 Gene
ACOD1 (Aconitate Decarboxylase 1) is a Protein Coding gene.
UniProtKB/Swiss-Prot for ACOD1 Gene
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.