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ACO1 Gene

protein-coding   GIFtS: 59

GC09P032374
aconitase 1, soluble
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IREB1)
Services    

Aliases &
Descriptions
for ACO1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ACONS 2
Aconitase 3
EC 4.2.1.3 3
IREB1 2, 3, 5
IREBP 1, 2
IREBP1 2
IRP1 1, 2, 3
OTTHUMP00000021176 2
OTTHUMP00000021177 2
OTTHUMP00000045233 2
Descriptions
Citrate hydro-lyase 2, 3
Ferritin repressor protein 2, 3
IRE-BP 1 3
Iron regulatory protein 1 2, 3
Iron-responsive element-binding protein 1 3
aconitase 1 2
aconitase 1, soluble 2
aconitate hydratase 2
iron-responsive element binding protein 1 2
External Ids
HGNC: 1171
Entrez Gene: 482
UniProtKB: P213993
Ensembl: ENSG000001227297
Search outside databases for aliases for ACO1 gene

Previous GC identifers: GC09P032696 GC09P032554

Summaries
for ACO1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for ACO1:
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic
protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the
5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The
iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and
inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus,
IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase
activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACOC_HUMAN, P21399
Function: Binds to iron-responsive elements (IRES), which are stem-loop structures found in the
5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin
receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA
translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of
this otherwise rapidly degraded mRNA. This protein also expresses aconitase activity

Genomic Location
for ACO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ACO1 gene  

Entrez Gene cytogenetic band: 9p22-q32|9p21.1   Ensembl cytogenetic band:  9p21.1   HGNC cytogenetic band: 9p21.1

ACO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P032374:     (about GC identifiers)

Start:
 32,374,618 bp from pter
End:
 32,440,834 bp from pter
Size:
 66,217 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  

Proteins
for ACO1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ACOC_HUMAN, P21399 (See protein sequence)
Recommended Name: Cytoplasmic aconitate hydratase  
Size: 889 amino acids; 98399 Da
Cofactor: Binds 1 4Fe-4S cluster per subunit (By similarity)
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
2B3X (3D)    2B3Y (3D)    
Secondary accessions: Q14652

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002188.1  

    ENSEMBL proteins: 
    ENSP00000369255 ENSP00000309477 ENSP00000369253 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Aconitase, Aconitase 1)
    Human Recombinant Proteins from Abnova (ACO1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm NAS1738601
    GO:0005783 endoplasmic reticulum IDA16144863
    GO:0005794 Golgi apparatus IDA16144863
    GO:0005829 cytosol IDA16527810
    About this table

    Antibodies for ACO1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of ACO1
    Sigma-Aldrich Antibodies for ACO1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Aconitase, Aconitase 1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ACO1)
    Novus Biologicals Antibodies for ACO1

    Assays for ACO1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ACO1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro domains/families (see all 9 ):
     IPR001030 Acoase/IPM_deHydtase_lsu_aba
     IPR018136 Aconitase_4Fe-4S_BS
     IPR000573 AconitaseA/IPMdHydase_ssu_swvl
     IPR015932 Aconitase/IPMdHydase_lsu_aba_2
     IPR015934 Aconitase/Fe_reg_prot_2/AcnD


       GeneDecks  ACO1 for the domains selected above  
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    Graphical View of Domain Structure for InterPro Entry P21399

    ProtoNet protein and cluster: P21399

    2 Blocks protein families:
    IPB000573 Aconitate hydratase
    IPB001030 Aconitate hydratase


    UniProtKB/Swiss-Prot: ACOC_HUMAN, P21399
    Similarity: Belongs to the aconitase/IPM isomerase family

    Gene Function
    for ACO1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ACO1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACO1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002197

                  Applied Biosystems Silencer® siRNAs for ACO1

                  Sigma-Aldrich siRNA for ACO1  
                         Sigma-Aldrich shRNA for ACO1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ACO1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002197
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002197
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002197 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002197

    UniProtKB/Swiss-Prot: ACOC_HUMAN, P21399
    Function: Binds to iron-responsive elements (IRES), which are stem-loop structures found in the
    5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin
    receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA
    translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of
    this otherwise rapidly degraded mRNA. This protein also expresses aconitase activity
    Catalytic activity: Citrate = isocitrate
    Enzyme Number (IUBMB): EC 4.2.1.3 

    Genatlas biochemistry entry for ACO1:
    bifunctional cytosolic aconitase,iron-responsive element binding protein

    3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Aco1):

    homeostasis/metabolismlethality-prenatal/perinatalnormal

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding NAS1903202
    GO:0003994 aconitate hydratase activity IDA1946430
    GO:0005506 iron ion binding IEA--
    GO:0016829 lyase activity IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for ACO1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for ACO1 (Maps provided by GeneGo):
     Citric acid cycle (citrate cycle

       GeneDecks  ACO1 for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  ACO1  (Your Favorite Gene powered by Ingenuity) 
     Citrate Cycle
     Glyoxylate and Dicarboxylate Metabolism

       GeneDecks  ACO1 for the pathways selected above  
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    3 Kegg Pathways  (Kegg details for ACO1):
     hsa00020 Citrate cycle (TCA cycle)
     hsa00630 Glyoxylate and dicarboxylate metabolism
     hsa00720 Reductive carboxylate cycle (CO2 fixation)

       GeneDecks  ACO1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ACO1 


    5/38 Interacting proteins for ACO1 (ENSP000003094773) via UniProtKB, MINT, and/or STRING (see all 38 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FTLENSP000003665253STRING (score=.981)
    TFRCENSP000003532243STRING (score=.972)
    IDH2ENSP000003318973STRING (score=.964)
    CSENSP000003420563STRING (score=.962)
    IDH1ENSP000002609853STRING (score=.956)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006099 tricarboxylic acid cycle IEA--
    GO:0006101 citrate metabolic process IDA16527810
    GO:0008152 metabolic process IEA--
    About this table

    Drugs & Compounds
    for ACO1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ACO1
    10/23 Novoseek chemical compound relationships for ACO1 gene (see all 23 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 87.78 704 11779155 (7), 9950149 (6), 11812787 (6), 10704227 (6) (see all 99)
    iron-sulfur 86.27 46 1421965 (2), 8203918 (2), 9092825 (2), 17244191 (2) (see all 32)
    cubane 72.79 4 12972614 (1), 15636585 (1), 18274988 (1), 8349646 (1)
    cis-aconitate 68.68 1 10419470 (1)
    5-aminolevulinic acid 64.54 4 11741608 (1), 10522551 (1), 8290565 (1), 7881153 (1)
    deferoxamine 57.27 5 10704227 (1), 8727377 (1), 12547239 (1), 17200797 (1)
    2-mercaptoethanol 53.18 6 1856222 (2), 10816424 (1), 7657289 (1)
    isocitrate 49.27 1 11085915 (1)
    diamide 43.31 1 8349646 (1)
    peroxynitrite 41.98 10 9242665 (3), 12459918 (3), 12820873 (2), 9325434 (1) (see all 5)
    About this table


    Transcripts
    for ACO1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ACO1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACO1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002197

                  Sigma-Aldrich siRNA for ACO1  
                         Sigma-Aldrich shRNA for ACO1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002197  

    REFSEQ mRNAs for ACO1 gene: 

    NM_002197.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002197  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002197
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002197
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002197 

    Additional cDNA sequence: 

    AB209480.1 AF261088.1 AK057904.1 AK308752.1 BC018103.1 BX538349.1 M58510.1 Z11559.1 

    9 DOTS entries:

    DT.101974581  DT.455868  DT.100791889  DT.101976511  DT.121166310  DT.100791888  DT.121166345  DT.91896374 
    DT.95318930 

    24/304 AceView cDNA sequences (see all 304 ):

    BU626878 H16014 AI168068 AA375771 BM712939 BE389852 BF593454 AV708239 
    CB164755 AI127153 AU142320 CA308058 BM673910 CN482557 BQ948863 D25618 
    BV178824 AW172911 CB115318 BU517058 BP382141 BM458955 CD518204 BM564913 

    highest scoring ESTs for ACO1:

    Z11559 AA114872 AA120998 AA121537 AA122326 AA127701 AA156728 AA156988 AA448706 AA488407 

    Unigene Cluster for ACO1:

    Aconitase 1, soluble
    Hs.567229  [show with all ESTs]
    Unigene Representative Sequence: AB209480


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000379923  ENST00000309951  ENST00000379921  

    Expression
    for ACO1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ACO1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ACO1

    1 / 2 / 3

    3 probe-sets matching ACO1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40077_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 Z11559 1.00 1.00 1.00 1

    		207071_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002197 0.60 1.00 0.82 1

    		207071_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ACO1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GATAGGTCGG

    SOURCE GeneReport for Unigene cluster: Hs.567229

    Expression variation in blood from EXPOLDB for ACO1

    Orthologs
    for ACO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ACO1 gene from 5/21 species (see all 21 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ACO11   -- aconitase 1, soluble 89.31(n)
    93.25(a)    		 481576  XM_538698.2  XP_538698.2 
    chimpanzee
    (Pan troglodytes)    		 ACO11   -- aconitase 1, soluble 99.59(n)
    99.89(a)    		 465034  XM_520523.2  XP_520523.2 
    cow
    (Bos taurus)    		 ACO11   -- aconitase 1, soluble 90.59(n)
    94.38(a)    		 512995  NM_001075591.1  NP_001069059.1 
    rat
    (Rattus norvegicus)    		 Aco11   -- aconitase 1, soluble 87.29(n)
    92.91(a)    		 50655  NM_017321.1  NP_059017.1 
    mouse
    (Mus musculus)    		 Aco11, 5 4 (20.90 cM)5
    		 aconitase 11, 5 86.91(n)1
    93.36(a)1    		 114281  NM_007386.21  NP_031412.21 
     AI2565195  AJ4273445  (see all 25)
    About this table        Species with no ortholog for ACO1

    ENSEMBL Gene Tree for ACO1

    Paralogs
    for ACO1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ACO1 gene
    IREB22  ACO22  

    SNPs/Variants
    for ACO1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/351 NCBI SNPs in ACO1 are shown (see all 351 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 140)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs129851,2
    		A,C,F,H32440187(+) CTCCCC/TGGCTG 1 -- ut31 ese35Minor allele frequency- T:0.49MN EA WA 1558
    rs70420421,2
    		A,C,F,H32441144(+) TAGTCG/ATTTCT 1 -- ng3112Minor allele frequency- A:0.42EU EA WA NA 1054
    rs8794501,2
    		A,C,F,H32373600(-) CTATCG/ATCTAG 1 -- ng515Minor allele frequency- A:0.02NA EA EU WA 456
    rs8674691,2
    		A,C,F,H32373708(+) AAGACG/AGGTAA 1 -- ng514Minor allele frequency- A:0.37EU EA WA 420
    rs38145191,2
    		C,F32414659(-) CCTTGG/TCTCCA 1 A/D mis14Minor allele frequency- T:0.03EU EA WA 420
    rs346304591,2
    		C,F32417406(-) GACTCC/TGCTTT 1 G/R mis15Minor allele frequency- T:0.03NA EU EA WA 492
    rs70253361,2
    		H32414645(+) TTTGAG/TAGCTG 1 E/D mis1 ese34Minor allele frequency- T:0.00EU EA WA 420
    rs37804731,2
    		C,F,H32415910(-) GTGAAC/TTCAGT 1 E/E syn1 ese318Minor allele frequency- N:0.00EA NA EU WA 3016
    rs343198391,2
    		F32415898(-) TTATCA/GTAGAT 1 Y/Y syn11Minor allele frequency- G:0.03NA 70
    rs353705051,2
    		F32417396(-) TCTTGT/CAGGTA 1 L/L syn11Minor allele frequency- C:0.04NA 72
    About this table

    HapMap Linkage Disequilibrium images for ACO1 (up to first 250kb)

    Disorders & Mutations
    for ACO1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 100880

    10/12 Novoseek disease relationships for ACO1 gene (see all 12 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron deficiency 60.02 13 8668195 (2), 17877204 (2), 9950149 (1), 9092514 (1) (see all 7)
    iron overload 59.67 2 7657289 (1), 12196178 (1)
    hereditary hemochromatosis 51.65 4 16503547 (2), 11783942 (1), 16531245 (1)
    friedreich ataxia 40.15 2 15970401 (2)
    hemochromatosis 29.59 11 7657289 (7), 11783942 (1)
    iron deficiency anemia 27.43 2 16503547 (1), 17877204 (1)
    erythroleukemia 15.73 1 9933651 (1)
    neurofibrillary tangles 8.68 1 9555030 (1)
    parkinson disease 6.99 1 12423242 (1)
    cancer 3.75 1 18274988 (1)
    About this table

    Medical News
    for ACO1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ACO1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/212 PubMed articles for ACO1 gene (see all 212 ):

    Search for ACO1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ACO1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 48 HGNC: 117 AceView: ACO1 Ensembl:ENSG00000122729 euGenes: HUgn48
    ECgene: ACO1 H-InvDB: ACO1

    Other Databases showing ACO1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing ACO1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Aconitase

    Licensable Technologies
    for ACO1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ACO1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ACO1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ACO1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ACO1 Antibodies for ACO1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ACO1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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