ACN9 Gene
protein-coding GIFtS: 45
GCID: GC07P096745
|
|
ACN9 homolog (S. cerevisiae)
| |
Aliases
for ACN9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ACN9 Homolog (S. Cerevisiae)1 2 | | DC111 | | Protein ACN9 Homolog, Mitochondrial2 |
Export aliases for ACN9 gene to outside databasesPrevious GC identifers: GC07P096343 GC07P096358 GC07P096357 GC07P096390 GC07P096583 GC07P091347 |
Summaries
for ACN9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ACN9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ACN9 gene promoter:
AhR Sox5 HOXA3 Lmo2 MyoD Nkx2-5 POU3F2 Arnt Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACN9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACN9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.3 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q22.1ACN9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P096745: view genomic region
(about GC identifiers)
Start:
|
96,745,902 bp from pter |
End:
|
96,811,075 bp from pter |
Size:
|
65,174 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 96,068,386-96,133,557 |
|
Proteins
for ACN9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACN9_HUMAN, Q9NRP4 (See
protein sequence)Recommended Name: Protein ACN9 homolog, mitochondrial precursor Size: 125 amino acids; 14652 Da
Subcellular location: Mitochondrion (Potential)
Secondary accessions: A4D1J3 Q75MD6Explore the universe of human proteins at neXtProt for ACN9: NX_Q9NRP4
ACN9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064571.1
ENSEMBL proteins: ENSP00000414066 ENSP00000353548
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ACN9 for ontologies About GeneDecksing
ACN9 Antibody Products:
Assay Products for ACN9: |
Protein
Domains /
Families
for ACN9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACN9 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NRP4ProtoNet protein and cluster: Q9NRP4 UniProtKB/Swiss-Prot: ACN9_HUMAN, Q9NRP4Similarity: Belongs to the ACN9 family |
Function
for ACN9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACN9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACN9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ACN9 (NM_020186) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACN9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACN9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACN9 |
|
Pathways & Interactions
for ACN9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACN9
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ACN9 (ENSP000004140664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006111 | regulation of gluconeogenesis |
ISS | -- |
ACN9 for ontologies About GeneDecksing
|
Drugs & Compounds
for ACN9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACN9
Search CenterWatch for drugs/clinical trials and news about ACN9
|
Transcripts
for ACN9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACN9 gene: NM_020186.2 Unigene Cluster for ACN9: ACN9 homolog (S. cerevisiae) Hs.592269 [show with all ESTs]Unigene Representative Sequence: BC0284094 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432641(uc003uoo.4) ENST00000489852 ENST00000360382 ENST00000479853
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACN9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACN9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ACN9 (NM_020186) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACN9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACN9 |
Additional cDNA sequence: AF201933.1 BC020621.1 BC022858.1 BC028409.1 7 DOTS entries: DT.311878 DT.95164351 DT.92434044 DT.121125907 DT.92434045 DT.97842098 DT.92434037 24/109 AceView cDNA sequences (see all 109): BF431067 BI757307 BF726604 BC020621 AI277092 BU625859 BM449806 AI147351 AW006468 CF529807 BU784747 CD683991 BQ278235 AA889020 BC028409 AF201933 BG166197 BM704439 AI873845 CF529956 BG618011 AA810407 BM829769 AI640867
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ACN9 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | | | | |
ECgene alternative splicing isoforms for ACN9
|
Expression
for ACN9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACN9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTTCTTC
About this image
See ACN9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACN9
SOURCE GeneReport for Unigene cluster: Hs.592269
SABiosciences Custom PCR Arrays for ACN9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACN9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACN9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACN9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACN9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACN9 |
Orthologs
for ACN9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ACN9 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for ACN9 (if available)
TreeFam Gene Tree for ACN9 (if available) |
Paralogs
for ACN9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACN9 gene
ACN9 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ACN9
PGOHUM00000244101
|
Genomic Variants
for ACN9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACN9 (96745902 - 96811075 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ACN9
2 CNVs: 94714 94713 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACN9 |
|
Disorders
/ Diseases
for ACN9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ACN9 for disorders About GeneDecksing
3  diseases for ACN9: About MalaCardsacne alcohol dependence alcoholism
Human Genome Epidemiology (HuGE) Navigator: ACN9 (5 documents)
Export disorders for ACN9 gene to outside databases
|
Publications
for ACN9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACN9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACN9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Acn9 is a novel protein of gluconeogenesis that is located in the mitochondrial intermembrane space. (PubMed id 10103055)1, 9 Dennis R.A. and McCammon M.T. (1999)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. (PubMed id 18163977)1 Dick D.M....Goate A. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ACN9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ACN9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACN9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACN9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ACN9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ACN9 gene:
Search GeneIP for patents involving ACN9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACN9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ACN9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACN9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACN9 | | | OriGene Protein Over-expression Lysate for ACN9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ACN9 | | OriGene 3'-UTR Clone for ACN9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACN9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACN9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ACN9 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ACN9 | | OriGene Custom Protein Services for ACN9 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACN9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACN9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACN9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACN9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACN9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACN9 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ACN9 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ACN9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACN9 |
|  |  |  | | | | ThermoFisher Antibodies for ACN9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACN9 |
|
|
|
|
