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Aliases for ACMSD Gene

Aliases for ACMSD Gene

  • Aminocarboxymuconate Semialdehyde Decarboxylase 2 3
  • EC 4.1.1.45 4 63
  • Picolinate Carboxylase 4

External Ids for ACMSD Gene

Previous GeneCards Identifiers for ACMSD Gene

  • GC02P133241
  • GC02P133883
  • GC02P135618
  • GC02P135806
  • GC02P135429
  • GC02P135312
  • GC02P127587
  • GC02P135596

Summaries for ACMSD Gene

Entrez Gene Summary for ACMSD Gene

  • The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]

GeneCards Summary for ACMSD Gene

ACMSD (Aminocarboxymuconate Semialdehyde Decarboxylase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include aminocarboxymuconate-semialdehyde decarboxylase activity.

UniProtKB/Swiss-Prot for ACMSD Gene

  • Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACMSD Gene

Genomics for ACMSD Gene

Genomic Location for ACMSD Gene

Start:
134,838,430 bp from pter
End:
134,902,076 bp from pter
Size:
63,647 bases
Orientation:
Plus strand

Genomic View for ACMSD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACMSD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACMSD Gene

Proteins for ACMSD Gene

  • Protein details for ACMSD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDX5-ACMSD_HUMAN
    Recommended name:
    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
    Protein Accession:
    Q8TDX5
    Secondary Accessions:
    • Q3B7X3
    • Q53SR5
    • Q96KY2

    Protein attributes for ACMSD Gene

    Size:
    336 amino acids
    Molecular mass:
    38035 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for ACMSD Gene

    Alternative splice isoforms for ACMSD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACMSD Gene

Proteomics data for ACMSD Gene at MOPED

Selected DME Specific Peptides for ACMSD Gene

Post-translational modifications for ACMSD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACMSD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ACMSD Gene

Protein Domains for ACMSD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACMSD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDX5

UniProtKB/Swiss-Prot:

ACMSD_HUMAN :
  • Q8TDX5
Family:
  • Belongs to the ACMSD family.
genes like me logo Genes that share domains with ACMSD: view

No data available for Gene Families for ACMSD Gene

Function for ACMSD Gene

Molecular function for ACMSD Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO(2).
UniProtKB/Swiss-Prot Function: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

Enzyme Numbers (IUBMB) for ACMSD Gene

Gene Ontology (GO) - Molecular Function for ACMSD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity IDA 12140278
GO:0003824 catalytic activity --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ACMSD: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACMSD Gene

Localization for ACMSD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACMSD Gene COMPARTMENTS Subcellular localization image for ACMSD gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ACMSD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 12140278
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ACMSD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACMSD Gene

Pathways for ACMSD Gene

genes like me logo Genes that share pathways with ACMSD: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q8TDX5-ACMSD_HUMAN

  • Pathway: Secondary metabolite metabolism; quinolate metabolism

Interacting Proteins for ACMSD Gene

Gene Ontology (GO) - Biological Process for ACMSD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006569 tryptophan catabolic process TAS --
GO:0008152 metabolic process --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046874 quinolinate metabolic process IDA 12140278
genes like me logo Genes that share ontologies with ACMSD: view

Compounds for ACMSD Gene

(4) HMDB Compounds for ACMSD Gene

Compound Synonyms Cas Number PubMed IDs
2-Amino-3-carboxymuconic acid semialdehyde
  • ACS
16597-58-3
2-Aminomuconic acid
  • 2-Aminomuconate
4548-99-6
2-Aminomuconic acid semialdehyde
  • 2-Aminomuconate 6-semialdehyde
245128-91-0
Carbon dioxide
  • Carbon oxide
124-38-9

(10) Novoseek inferred chemical compound relationships for ACMSD Gene

Compound -log(P) Hits PubMed IDs
2-amino-3-carboxymuconate-6-semialdehyde 98.5 8
2-nitrobenzoic acid 88.2 1
3-hydroxyanthranilic acid 88.1 1
quinolinic acid 85.2 10
picolinic acid 82.5 1
genes like me logo Genes that share compounds with ACMSD: view

Transcripts for ACMSD Gene

Unigene Clusters for ACMSD Gene

Aminocarboxymuconate semialdehyde decarboxylase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACMSD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACMSD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for ACMSD Gene

GeneLoc Exon Structure for
ACMSD
ECgene alternative splicing isoforms for
ACMSD

Expression for ACMSD Gene

mRNA expression in normal human tissues for ACMSD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACMSD Gene

This gene is overexpressed in Liver (29.3) and Kidney - Cortex (22.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ACMSD Gene

SOURCE GeneReport for Unigene cluster for ACMSD Gene Hs.655728

genes like me logo Genes that share expressions with ACMSD: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ACMSD Gene

Orthologs for ACMSD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACMSD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACMSD 35
  • 99.21 (n)
  • 99.7 (a)
ACMSD 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACMSD 35
  • 89.38 (n)
  • 90.18 (a)
ACMSD 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACMSD 35
  • 89.48 (n)
  • 90.77 (a)
ACMSD 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acmsd 35
  • 86.51 (n)
  • 87.2 (a)
Acmsd 16
Acmsd 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACMSD 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACMSD 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acmsd 35
  • 84.92 (n)
  • 86.01 (a)
chicken
(Gallus gallus)
Aves ACMSD 35
  • 75.99 (n)
  • 80.65 (a)
ACMSD 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACMSD 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acmsd 35
  • 70.44 (n)
  • 75.3 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10505 35
zebrafish
(Danio rerio)
Actinopterygii acmsd 35
  • 73.21 (n)
  • 81.25 (a)
acmsd 36
  • 81 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y71D11A.3 35
  • 55.32 (n)
  • 51.98 (a)
Y71D11A.3 36
  • 43 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06417 35
  • 45.5 (n)
  • 33.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.63 35
Species with no ortholog for ACMSD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACMSD Gene

ENSEMBL:
Gene Tree for ACMSD (if available)
TreeFam:
Gene Tree for ACMSD (if available)

Paralogs for ACMSD Gene

No data available for Paralogs for ACMSD Gene

Variants for ACMSD Gene

Sequence variations from dbSNP and Humsavar for ACMSD Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs998039 -- 134,855,347(+) CTGGA(C/T)ACTGC intron-variant
rs1374293 -- 134,840,689(-) AGCTG(C/G)TGATA intron-variant
rs1446523 -- 134,859,051(+) TTGAC(A/G)CCCAC intron-variant
rs1530555 -- 134,842,169(-) ATGCC(A/G)GGAAG intron-variant
rs1530556 -- 134,842,164(-) GGGAA(A/G)CATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACMSD Gene

Variant ID Type Subtype PubMed ID
esv2672210 CNV Deletion 23128226
esv268160 CNV Insertion 20981092

Relevant External Links for ACMSD Gene

HapMap Linkage Disequilibrium report
ACMSD
Human Gene Mutation Database (HGMD)
ACMSD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACMSD Gene

Disorders for ACMSD Gene

Relevant External Links for ACMSD

Genetic Association Database (GAD)
ACMSD
Human Genome Epidemiology (HuGE) Navigator
ACMSD
genes like me logo Genes that share disorders with ACMSD: view

No data available for UniProtKB/Swiss-Prot for ACMSD Gene

Publications for ACMSD Gene

  1. Identification and expression of a cDNA encoding human alpha-amino- beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'. (PMID: 12140278) Fukuoka S. … Shibata K. (J. Biol. Chem. 2002) 2 3 4 23
  2. The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis. (PMID: 19843166) Garavaglia S. … Rizzi M. (FEBS J. 2009) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) . … Wood N.W. (Lancet 2011) 3 48
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for ACMSD Gene

Sources for ACMSD Gene

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