Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ACMSD Gene

protein-coding   GIFtS: 55
GCID: GC02P135596

Aminocarboxymuconate Semialdehyde Decarboxylase

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Aminocarboxymuconate Semialdehyde Decarboxylase1 2
Picolinate Carboxylase2 3
EC 4.1.1.453 8
2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase2

External Ids:    HGNC: 192881   Entrez Gene: 1300132   Ensembl: ENSG000001530867   OMIM: 6088895   UniProtKB: Q8TDX53   

Export aliases for ACMSD gene to outside databases

Previous GC identifers: GC02P133241 GC02P133883 GC02P135618 GC02P135806 GC02P135429 GC02P135312 GC02P127587


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ACMSD Gene:
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan,
and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from
alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert
ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.(supplied by OMIM, Oct
2004)

GeneCards Summary for ACMSD Gene:
ACMSD (aminocarboxymuconate semialdehyde decarboxylase) is a protein-coding gene. GO annotations related to this gene include aminocarboxymuconate-semialdehyde decarboxylase activity.

UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
Function: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate
semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a
potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various
neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD
ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACMSD gene promoter:
         COUP-TF1   COUP   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   HNF-4alpha2   POU3F2   C/EBPalpha   HNF-4alpha1   PPAR-alpha   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACMSD promoter sequence
   Search Chromatin IP Primers for ACMSD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACMSD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

ACMSD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACMSD gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P135596:  view genomic region     (about GC identifiers)

Start:
135,596,117 bp from pter      End:
135,659,604 bp from pter
Size:
63,488 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5 (See protein sequence)
Recommended Name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase  
Size: 336 amino acids; 38035 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for ACMSD:
2WM1 (3D)    
Secondary accessions: Q3B7X3 Q53SR5 Q96KY2
Alternative splicing: 2 isoforms:  Q8TDX5-1   Q8TDX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACMSD: NX_Q8TDX5

Explore proteomics data for ACMSD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACMSD (Q8TDX5) (see all 5)
     LFVHPWDM  LGTDYPFPLGE  RFVGLGTLPMQAP  LSTVPVMFSYWAKP 


    See ACMSD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612199.2  
    ENSEMBL proteins: 
     ENSP00000348459   ENSP00000376659   ENSP00000283054  
    Reactome Protein details: Q8TDX5

    ACMSD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACMSD
    OriGene Protein Over-expression Lysate for ACMSD
    OriGene MassSpec for ACMSD
    OriGene Custom Protein Services for ACMSD
    GenScript Custom Purified and Recombinant Proteins Services for ACMSD
    Novus Biologicals ACMSD Proteins
    Novus Biologicals ACMSD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACMSD

     
    Search eBioscience for Proteins for ACMSD 

     
    antibodies-online proteins for ACMSD (9 products) 

     
    antibodies-online peptides for ACMSD

    ACMSD Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACMSD
    OriGene Custom Antibody Services for ACMSD
    Novus Biologicals ACMSD Antibodies
    Abcam antibodies for ACMSD
    Cloud-Clone Corp. Antibodies for ACMSD
    ThermoFisher Antibody for ACMSD
    LSBio Antibodies in human, mouse, rat for ACMSD
    antibodies-online antibodies for ACMSD (11 products) 

    ACMSD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACMSD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACMSD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACMSD
    Cloud-Clone Corp. CLIAs for ACMSD
    Search eBioscience for ELISAs for ACMSD 
    antibodies-online kits for ACMSD (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR006992 Amidohydro_2

    Graphical View of Domain Structure for InterPro Entry Q8TDX5

    ProtoNet protein and cluster: Q8TDX5

    UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
    Similarity: Belongs to the ACMSD family


    Find genes that share domains with ACMSD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACMSD_HUMAN, Q8TDX5
    Function: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate
    semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a
    potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various
    neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD
    ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway
    Catalytic activity: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO(2)

         Enzyme Number (IUBMB): EC 4.1.1.451 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001760aminocarboxymuconate-semialdehyde decarboxylase activity IDA12140278
    GO:0003824catalytic activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ACMSD           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACMSD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACMSD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACMSD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACMSD

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ACMSD using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ACMSD:
    hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidACMSD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACMSD
    Predesigned siRNA for gene silencing in human, mouse, rat ACMSD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACMSD

    Clone
    Products:
         
    OriGene clones in human, mouse for ACMSD (see all 6)
    OriGene ORF clones in mouse, rat for ACMSD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACMSD (NM_138326)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACMSD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACMSD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACMSD
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACMSD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACMSD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    peroxisome2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA12140278

    Find genes that share ontologies with ACMSD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ACMSD About    
    See pathways by source

    SuperPathContained pathways About
    1Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan catabolism0.00
    Tryptophan metabolism0.46
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    tryptophan degradation via kynurenine0.00
    4tryptophan utilization II
    tryptophan utilization II0.71
    tryptophan degradation0.00
    tryptophan utilization I0.71
    2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA0.00


    Find genes that share SuperPaths with ACMSD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for ACMSD (see all 6)
        tryptophan degradation via kynurenine
    Tryptophan metabolism
    tryptophan degradation
    2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA
    tryptophan utilization II

    1 Reactome Pathway for ACMSD
        Tryptophan catabolism


    2 Kegg Pathways  (Kegg details for ACMSD):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
    Pathway: Secondary metabolite metabolism; quinolate metabolism

        Pathway & Disease-focused RT2 Profiler PCR Array including ACMSD: 

              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ACMSD

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ACMSD (Q8TDX52, 3 ENSP000003484594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-67614 I2D: score=4 STRING: ENSP00000347358
    HAAOENSP000002949734STRING: ENSP00000294973
    RABAC1ENSP000002220084STRING: ENSP00000222008
    MOCS1ENSP000003622824STRING: ENSP00000362282
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006569tryptophan catabolic process TAS--
    GO:0008152metabolic process ----
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046874quinolinate metabolic process IDA12140278

    Find genes that share ontologies with ACMSD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACMSD

    4 HMDB Compounds for ACMSD    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Amino-3-carboxymuconic acid semialdehydeACS (see all 9)16597-58-3--
    2-Aminomuconic acid2-Aminomuconate (see all 5)4548-99-6--
    2-Aminomuconic acid semialdehyde2-Aminomuconate 6-semialdehyde (see all 3)245128-91-0--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--

    10 Novoseek inferred chemical compound relationships for ACMSD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-amino-3-carboxymuconate-6-semialdehyde 98.5 16 11802786 (2), 15206762 (2), 17288562 (2), 15466039 (1) (see all 5)
    2-nitrobenzoic acid 88.2 1 16131206 (1)
    3-hydroxyanthranilic acid 88.1 1 10966936 (1)
    quinolinic acid 85.2 14 15206762 (3), 15229365 (2), 12140278 (2), 16939194 (1) (see all 6)
    picolinic acid 82.5 2 19843166 (1)
    kynurenine 70.3 1 10966936 (1)
    cobalt 52.4 1 19081971 (1)
    niacin 50 1 8866254 (1)
    quinine 47.9 1 15246871 (1)
    acetyl-coa 47.5 2 15229365 (1), 16939194 (1)



    Find genes that share compounds with ACMSD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ACMSD gene: 
    NM_138326.2  

    Unigene Cluster for ACMSD:

    Aminocarboxymuconate semialdehyde decarboxylase
    Hs.655728  [show with all ESTs]
    Unigene Representative Sequence: AK125008
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356140(uc002ttz.3) ENST00000485893 ENST00000392928(uc002tua.3)
    ENST00000498093 ENST00000283054
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACMSD using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ACMSD:
    hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidACMSD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACMSD
    Predesigned siRNA for gene silencing in human, mouse, rat ACMSD
    Clone
    Products:
         
    OriGene clones in human, mouse for ACMSD (see all 6)
    OriGene ORF clones in mouse, rat for ACMSD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACMSD (NM_138326)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACMSD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACMSD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACMSD
    OriGene qSTAR qPCR primer pairs in human, mouse for ACMSD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACMSD
      QuantiTect SYBR Green Assays in human, mouse, rat ACMSD
      QuantiFast Probe-based Assays in human, mouse, rat ACMSD

    Additional mRNA sequence: 

    AB071418.1 AK125008.1 BC016018.1 BC107420.1 

    5 DOTS entries:

    DT.95367327  DT.110757  DT.91994451  DT.101591  DT.75193412 

    Selected AceView cDNA sequences (see all 37):

    AB071418 BC016018 AW296086 AW025340 BI759827 BX106606 AA770062 AK125008 
    R06001 AA865292 AI084813 BG567318 AI695273 AL700060 BG428338 AA918016 
    BI765661 BG399101 AA862426 NM_138326 AA702020 N67609 BG427004 BG402220 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ACMSD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
    SP1:                                      -                                   -               
    SP2:                    -                                                     -               
    SP3:                    -                                                                     
    SP4:                                      -                                                   


    ECgene alternative splicing isoforms for ACMSD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ACMSD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAATTTG
    ACMSD Expression
    About this image


    ACMSD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
    ACMSD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACMSD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655728
        Pathway & Disease-focused RT2 Profiler PCR Array including ACMSD: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACMSD
    OriGene qSTAR qPCR primer pairs in human, mouse for ACMSD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACMSD
    QuantiTect SYBR Green Assays in human, mouse, rat ACMSD
    QuantiFast Probe-based Assays in human, mouse, rat ACMSD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACMSD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ACMSD gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acmsd1 , 5 amino carboxymuconate semialdehyde decarboxylase1, 5 86.51(n)1
    87.2(a)1
      1 (55.80 cM)5
    2666451  NM_001033041.21  NP_001028213.11 
     1277294135 
    chicken
    (Gallus gallus)
    Aves ACMSD1 aminocarboxymuconate semialdehyde decarboxylase 75.99(n)
    80.65(a)
      424288  XM_422133.4  XP_422133.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACMSD6
    aminocarboxymuconate semialdehyde decarboxylase
    79(a)
    1 ↔ 1
    1(96416770-96445546)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia acmsd1 aminocarboxymuconate semialdehyde decarboxylase 70.44(n)
    75.3(a)
      100488272  XM_002941422.2  XP_002941468.2 
    zebrafish
    (Danio rerio)
    Actinopterygii acmsd1 aminocarboxymuconate semialdehyde decarboxylase 73.21(n)
    81.25(a)
      557166  NM_001089494.1  NP_001082963.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71D11A.31 Y71D11A.3 55.32(n)
    51.98(a)
      175280  NM_064935.7  NP_497336.3 


    ENSEMBL Gene Tree for ACMSD (if available)
    TreeFam Gene Tree for ACMSD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ACMSD (see all 531)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs621714431,2
    C--135594221(+) GACTTT/CCCAGC 1 -- us2k14Minor allele frequency- C:0.28NA WA EA 360
    rs621714441,2
    C,F--135594399(+) TTCTCA/CGAGAA 1 -- us2k15Minor allele frequency- C:0.13NA WA EA 362
    rs1821876551,2
    --135594408(+) AAAATG/TGTTAT 1 -- us2k10--------
    rs792176491,2
    C,F--135594436(+) CCTCAT/GAGTGA 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1388025951,2
    --135594467(+) TCCCTC/GTTTTT 1 -- us2k10--------
    rs1428252301,2
    C--135594545(+) AATGAA/GGGCAT 1 -- us2k10--------
    rs779187061,2
    C,F--135594661(+) TTCTCC/TCACAC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs752178111,2
    F--135594668(+) ACACAC/TTATTG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs19548741,2
    C,F,A,H--135594699(+) ttctcT/Cgtgct 1 -- us2k121Minor allele frequency- C:0.36NS EA WA NA CSA 2342
    rs1875804551,2
    --135594763(+) ATGTTA/GTGAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACMSD (135596117 - 135659604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACMSD:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672210CNV Deletion23128226
    esv268160CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACMSD
    DNA2.0 Custom Variant and Variant Library Synthesis for ACMSD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608889    OMIM disorders: --


    Find genes that share disorders with ACMSD           About GenesLikeMe

    Genetic Association Database (GAD): ACMSD
    Human Genome Epidemiology (HuGE) Navigator: ACMSD (1 document)

    Export disorders for ACMSD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ACMSD gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ACMSD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and expression of a cDNA encoding human alpha-amino- beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'. (PubMed id 12140278)1, 2, 3, 9 Fukuoka S.... Shibata K. (J. Biol. Chem. 2002)
    2. The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis. (PubMed id 19843166)1, 2, 9 Garavaglia S.... Rizzi M. (FEBS J. 2009)
    3. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PubMed id 21292315)1, 4  ....Wood N.W. (Lancet 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Identification and expression of alpha cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): a key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis. (PubMed id 15206762)9 Fukuoka S....Shibata K. (Adv. Exp. Med. Biol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 130013 HGNC: 19288 AceView: ACMSD Ensembl:ENSG00000153086 euGenes: HUgn130013
    ECgene: ACMSD Kegg: 130013 H-InvDB: ACMSD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ACMSD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ACMSD gene:
    Search GeneIP for patents involving ACMSD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACMSD   OriGene RNAi products in human, mouse, rat for ACMSD  
     OriGene qPCR primer pairs and template standards for ACMSD   OriGene Protein Over-expression Lysate for ACMSD  
     OriGene MassSpec for ACMSD   OriGene clones in human, mouse for ACMSD  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACMSD   OriGene Purified Protein for ACMSD  
     OriGene ORF clones in mouse, rat for ACMSD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACMSD   OriGene Custom Protein Services for ACMSD  

     
     
     Block miRNA regulation of human, mouse, rat ACMSD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ACMSD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACMSD Predesigned siRNA for gene silencing in human, mouse, rat ACMSD
     QuantiFast Probe-based Assays in human, mouse, rat ACMSD QuantiTect SYBR Green Assays in human, mouse, rat ACMSD
     PCR Arrays including human, mouse, rat ACMSD Search Chromatin IP Primers for ACMSD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACMSD  Search GeneGlobe Interaction Network for ACMSD
     Regulatory tfbs in ACMSD promoter
     GenScript Custom Purified and Recombinant Proteins Services for ACMSD GenScript cDNA clones with any tag delivered in your preferred vector for ACMSD
     GenScript Custom Assay Services for ACMSD GenScript Custom overexpressing Cell Line Services for ACMSD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ACMSD
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ACMSD antibodies
     ACMSD proteins
     ACMSD lysates
     Antibodies for ACMSD
     See all of Abcam's Antibodies, Kits and Proteins for ACMSD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ACMSD
     Antibodies for ACMSD
     ELISAs for ACMSD
     CLIAs for ACMSD



     Browse ESI BIO Cell Lines and PureStem Progenitors for ACMSD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACMSD
     SwitchGear 3'UTR luciferase reporter plasmids for ACMSD
     SwitchGear Promoter luciferase reporter plasmids for ACMSD
     ThermoFisher Antibody for ACMSD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACMSD
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACMSD
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACMSD
     LSBio Antibodies in human, mouse, rat for ACMSD
     Browse compounds at ApexBio
     Search Addgene for plasmids for ACMSD
      Search eBioscience for proteins for ACMSD
      Search eBioscience for elisas for ACMSD
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for ACMSD (11 products)
     antibodies-online kits for ACMSD (10 products)
     antibodies-online peptides for ACMSD
     antibodies-online proteins for ACMSD (9 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACMSD gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4