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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACMSD Gene

protein-coding   GIFtS: 54
GCID: GC02P135596

aminocarboxymuconate semialdehyde decarboxylase
 Explore 4 diseases affiliated with
ACMSD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ACMSD    

Aliases
for ACMSD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aminocarboxymuconate Semialdehyde Decarboxylase1 2
Picolinate Carboxylase2 3
EC 4.1.1.453 8
2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase2

External Ids:    HGNC: 192881   Entrez Gene: 1300132   Ensembl: ENSG000001530867   OMIM: 6088895   UniProtKB: Q8TDX53   

Export aliases for ACMSD gene to outside databases

Previous GC identifers: GC02P133241 GC02P133883 GC02P135618 GC02P135806 GC02P135429 GC02P135312 GC02P127587


Summaries
for ACMSD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ACMSD:
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and
has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from
alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS
to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.(supplied by OMIM, Oct 2004)

UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
Function: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde
(AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous
excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the
presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of
tryptophan catabolism along the kynurenine pathway




Genomic Views
for ACMSD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACMSD gene promoter:
         COUP-TF1   COUP   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   HNF-4alpha2   POU3F2   C/EBPalpha   HNF-4alpha1   PPAR-alpha   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACMSD promoter sequence
   Search SABiosciences Chromatin IP Primers for ACMSD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACMSD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

ACMSD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACMSD gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P135596:  view genomic region     (about GC identifiers)

Start:
 135,596,117 bp from pter      End:
 135,659,604 bp from pter
Size:
 63,488 bases      Orientation:
 plus strand

Proteins
for ACMSD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5 (See protein sequence)
Recommended Name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase  
Size: 336 amino acids; 38035 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for ACMSD:
2WM1 (3D)    
Secondary accessions: Q3B7X3 Q53SR5 Q96KY2
Alternative splicing: 2 isoforms:  Q8TDX5-1   Q8TDX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACMSD: NX_Q8TDX5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TDX5

    • 4/5 DME Specific Peptides for ACMSD (Q8TDX5) (see all 5)
     LFVHPWDM  LGTDYPFPLGE  RFVGLGTLPMQAP  LSTVPVMFSYWAKP 

    ACMSD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_612199.2  
    ENSEMBL proteins: 
     ENSP00000348459   ENSP00000376659   ENSP00000283054  
    Reactome Protein details: Q8TDX5
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ACMSD

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA12140278


    ACMSD for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ACMSD

    Protein Domains /
    Families
    for ACMSD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ACMSD for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006992 Amidohydro_2

    Graphical View of Domain Structure for InterPro Entry Q8TDX5

    ProtoNet protein and cluster: Q8TDX5

    UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
    Similarity: Belongs to the ACMSD family


    Function
    for ACMSD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
    Function: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde
    (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous
    excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the
    presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of
    tryptophan catabolism along the kynurenine pathway
    Catalytic activity: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO(2)

    Enzyme Number (IUBMB): EC 4.1.1.451 2

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ACMSD 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for ACMSD

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001760aminocarboxymuconate-semialdehyde decarboxylase activity IDA12140278
    GO:0016831carboxy-lyase activity ----
    GO:0046872metal ion binding IEA--


    ACMSD for ontologies           About GeneDecksing



    Pathways & Interactions
    for ACMSD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2Tryptophan metabolism
    		Tryptophan metabolism1.00
    		Tryptophan metabolism0.47
    3Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00
    4tryptophan degradation III (eukaryotic)
    		tryptophan degradation III (eukaryotic)1.00
    52-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA
    		2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for ACMSD 
        Tryptophan metabolism
    2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA
    tryptophan degradation III (eukaryotic)

    3        Reactome Pathways for ACMSD
        Tryptophan catabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for ACMSD):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
    Pathway: Secondary metabolite metabolism; quinolate metabolism


    ACMSD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACMSD

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ACMSD (Q8TDX52, 3 ENSP000003484594) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-67614 I2D: score=4 STRING: ENSP00000347358
    HAAOENSP000002949734STRING: ENSP00000294973
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006569tryptophan catabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046874quinolinate metabolic process IDA12140278


    ACMSD for ontologies           About GeneDecksing



    Drugs & Compounds
    for ACMSD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACMSD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACMSD

    4 HMDB Compounds for ACMSD    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Amino-3-carboxymuconic acid semialdehydeACS (see all 9)16597-58-3--
    2-Aminomuconic acid2-Aminomuconate (see all 5)4548-99-6--
    2-Aminomuconic acid semialdehyde2-Aminomuconate 6-semialdehyde (see all 3)245128-91-0--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    10 Novoseek chemical compound relationships for ACMSD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-amino-3-carboxymuconate-6-semialdehyde 98.5 16 11802786 (2), 15206762 (2), 17288562 (2), 15466039 (1) (see all 5)
    2-nitrobenzoic acid 88.2 1 16131206 (1)
    3-hydroxyanthranilic acid 88.1 1 10966936 (1)
    quinolinic acid 85.2 14 15206762 (3), 15229365 (2), 12140278 (2), 16939194 (1) (see all 6)
    picolinic acid 82.5 2 19843166 (1)
    kynurenine 70.3 1 10966936 (1)
    cobalt 52.4 1 19081971 (1)
    niacin 50 1 8866254 (1)
    quinine 47.9 1 15246871 (1)
    acetyl-coa 47.5 2 15229365 (1), 16939194 (1)

    Search CenterWatch for drugs/clinical trials and news about ACMSD 

    Transcripts
    for ACMSD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ACMSD gene: 
    NM_138326.2  

    Unigene Cluster for ACMSD:

    Aminocarboxymuconate semialdehyde decarboxylase
    Hs.655728  [show with all ESTs]
    Unigene Representative Sequence: AK125008
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356140(uc002ttz.3) ENST00000485893 ENST00000392928(uc002tua.3)
    ENST00000498093 ENST00000283054

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACMSD
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ACMSD:
    hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: ACMSD 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACMSD (see all 7)
    OriGene shRNA RFP: ACMSD
    OriGene siRNA: ACMSD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACMSD
    Clone
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    GenScript: all cDNA clones in your preferred vector: ACMSD (NM_138326)
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    Additional cDNA sequence: 

    AB071418.1 AK125008.1 BC016018.1 BC107420.1 

    5 DOTS entries:

    DT.95367327  DT.110757  DT.91994451  DT.101591  DT.75193412 

    24/37 AceView cDNA sequences (see all 37):

    BX106606 BI759827 AW025340 AK125008 AA770062 AW296086 BC016018 AB071418 
    AA702020 R06001 NM_138326 BG427004 AA862426 AI084813 BG567318 AA918016 
    BG399101 AL700060 BG402220 BG428338 AI695273 AW028479 N67609 AA865292 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ACMSD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
    SP1:                                      -                                   -               
    SP2:                    -                                                     -               
    SP3:                    -                                                                     
    SP4:                                      -                                                   


    ECgene alternative splicing isoforms for ACMSD

    Expression
    for ACMSD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACMSD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGAATTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ACMSD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Human kidney epithelial cell spheroids (Kidney spheroids for...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ACMSD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACMSD

    SOURCE GeneReport for Unigene cluster: Hs.655728
        SABiosciences Expression via Pathway-Focused PCR Array including ACMSD: 
              Amino Acid Metabolism I in human mouse rat

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    In Situ
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    Orthologs
    for ACMSD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ACMSD gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Acmsd1 , 5 amino carboxymuconate semialdehyde decarboxylase1, 5 86.51(n)1
    87.2(a)1    		   1 (55.80 cM)5
    2666451  NM_001033041.21  NP_001028213.11 
     1277294135 
    chicken
    (Gallus gallus)    		 Aves ACMSD1 aminocarboxymuconate semialdehyde decarboxylase 75.99(n)
    80.65(a)    		   424288  XM_422133.3  XP_422133.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ACMSD6
    		 --
    		 79(a)
    		 1 ↔ 1
    		 1(96416770-96441115)
    zebrafish
    (Danio rerio)    		 Actinopterygii acmsd1 aminocarboxymuconate semialdehyde decarboxylase 73.21(n)
    81.25(a)    		   557166  NM_001089494.1  NP_001082963.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y71D11A.31 Protein Y71D11A.3 55.42(n)
    51.98(a)    		   175280  NM_064935.6  NP_497336.3 


    ENSEMBL Gene Tree for ACMSD (if available)
    TreeFam Gene Tree for ACMSD (if available) 

    Paralogs
    for ACMSD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ACMSD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1074 NCBI SNPs in ACMSD are shown (see all 1074)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs621714431,2
    		C,--135594221(+) GACTTT/CCCAGC 1 -- us2k14Minor allele frequency- C:0.28NA WA EA 360
    rs621714441,2
    		C,F,--135594399(+) TTCTCA/CGAGAA 1 -- us2k15Minor allele frequency- C:0.13NA WA EA 362
    rs1821876551,2
    		--135594408(+) AAAATG/TGTTAT 1 -- us2k10--------
    rs792176491,2
    		F,--135594436(+) CCTCAT/GAGTGA 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1388025951,2
    		--135594467(+) TCCCTC/GTTTTT 1 -- us2k10--------
    rs1428252301,2
    		--135594545(+) AATGAA/GGGCAT 1 -- us2k10--------
    rs779187061,2
    		C,F,--135594661(+) TTCTCC/TCACAC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs752178111,2
    		F,--135594668(+) ACACAC/TTATTG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs19548741,2
    		C,F,A,H,--135594699(+) TTCTCT/CGTGCT 1 -- us2k121Minor allele frequency- C:0.36NS EA WA NA CSA 2342
    rs1875804551,2
    		--135594763(+) ATGTTA/GTGAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACMSD (135596117 - 135659604 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACMSD: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ACMSD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ACMSD for disorders           About GeneDecksing

    OMIM gene information: 608889    OMIM disorders: --

    4 diseases for ACMSD:    About MalaCards
    neuronitis    parkinson's disease    noma    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: ACMSD (1 document)

    Export disorders for ACMSD gene to outside databases

    Publications
    for ACMSD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACMSD gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ACMSD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and expression of a cDNA encoding human alpha-amino- beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'. (PubMed id 12140278)1, 2, 3, 9 Fukuoka S.... Shibata K. (2002)
    2. The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis. (PubMed id 19843166)1, 2, 9 Garavaglia S.... Rizzi M. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide associat ion studies. (PubMed id 21292315)1  ....Wood N.W. (2011)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Identification and expression of alpha cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): a key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis. (PubMed id 15206762)9 Fukuoka S....Shibata K. (2003)
    9. Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase. (PubMed id 11802786)9 Tanabe A....Sanada H. (2002)
    10. Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway. (PubMed id 15229365)9 Fukuwatari T....Shibata K. (2004)

    External Searches for ACMSD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ACMSD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 130013 HGNC: 19288 AceView: ACMSD Ensembl:ENSG00000153086 euGenes: HUgn130013
    ECgene: ACMSD Kegg: 130013 H-InvDB: ACMSD

    Other Databases showing ACMSD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ACMSD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACMSD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ACMSD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ACMSD gene:
    Search GeneIP for patents involving ACMSD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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