Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACMSD Gene

protein-coding   GIFtS: 55
GCID: GC02P135596

Aminocarboxymuconate Semialdehyde Decarboxylase

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aminocarboxymuconate Semialdehyde Decarboxylase1 2
Picolinate Carboxylase2 3
EC 4.1.1.453 8
2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase2

External Ids:    HGNC: 192881   Entrez Gene: 1300132   Ensembl: ENSG000001530867   OMIM: 6088895   UniProtKB: Q8TDX53   

Export aliases for ACMSD gene to outside databases

Previous GC identifers: GC02P133241 GC02P133883 GC02P135618 GC02P135806 GC02P135429 GC02P135312 GC02P127587


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACMSD Gene:
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan,
and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from
alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert
ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.(supplied by OMIM, Oct
2004)

GeneCards Summary for ACMSD Gene: 
ACMSD (aminocarboxymuconate semialdehyde decarboxylase) is a protein-coding gene. Diseases associated with ACMSD include parkinson's disease, and neuronitis, and among its related super-pathways are tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde and Tryptophan metabolism. GO annotations related to this gene include aminocarboxymuconate-semialdehyde decarboxylase activity and metal ion binding.

UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
Function: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate
semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a
potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various
neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD
ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACMSD gene promoter:
         COUP-TF1   COUP   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   HNF-4alpha2   POU3F2   C/EBPalpha   HNF-4alpha1   PPAR-alpha   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACMSD promoter sequence
   Search SABiosciences Chromatin IP Primers for ACMSD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACMSD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

ACMSD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACMSD gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P135596:  view genomic region     (about GC identifiers)

Start:
135,596,117 bp from pter      End:
135,659,604 bp from pter
Size:
63,488 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5 (See protein sequence)
Recommended Name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase  
Size: 336 amino acids; 38035 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for ACMSD:
2WM1 (3D)    
Secondary accessions: Q3B7X3 Q53SR5 Q96KY2
Alternative splicing: 2 isoforms:  Q8TDX5-1   Q8TDX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACMSD: NX_Q8TDX5

Explore proteomics data for ACMSD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDX5

  • 4/5 DME Specific Peptides for ACMSD (Q8TDX5) (see all 5)
     LFVHPWDM  LGTDYPFPLGE  RFVGLGTLPMQAP  LSTVPVMFSYWAKP 

    ACMSD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACMSD Protein Expression
    REFSEQ proteins: NP_612199.2  
    ENSEMBL proteins: 
     ENSP00000348459   ENSP00000376659   ENSP00000283054  
    Reactome Protein details: Q8TDX5
    Human Recombinant Protein Products for ACMSD: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACMSD
    OriGene Protein Over-expression Lysate for ACMSD
    OriGene MassSpec for ACMSD 
    OriGene Custom Protein Services for ACMSD
    GenScript Custom Purified and Recombinant Proteins Services for ACMSD
    Novus Biologicals ACMSD Proteins
    Novus Biologicals ACMSD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACMSD 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA12140278

    ACMSD for ontologies           About GeneDecksing



    ACMSD Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACMSD
    OriGene Custom Antibody Services for ACMSD
    GenScript Custom Superior Antibodies Services for ACMSD
    Novus Biologicals ACMSD Antibodies
    Abcam antibodies for ACMSD
    Cloud-Clone Corp. Antibodies for ACMSD 
    ThermoFisher Antibody for ACMSD
    LSBio Antibodies in human, mouse, rat for ACMSD 

    Assay Products for ACMSD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACMSD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACMSD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACMSD 
    Cloud-Clone Corp. CLIAs for ACMSD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006992 Amidohydro_2

    Graphical View of Domain Structure for InterPro Entry Q8TDX5

    ProtoNet protein and cluster: Q8TDX5

    UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
    Similarity: Belongs to the ACMSD family


    ACMSD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACMSD_HUMAN, Q8TDX5
    Function: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate
    semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a
    potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various
    neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD
    ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway
    Catalytic activity: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO(2)

         Enzyme Number (IUBMB): EC 4.1.1.451 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001760aminocarboxymuconate-semialdehyde decarboxylase activity IDA12140278
    GO:0003824catalytic activity ----
    GO:0046872metal ion binding IEA--
         
    ACMSD for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACMSD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACMSD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACMSD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACMSD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACMSD
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ACMSD:
    hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidACMSD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACMSD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACMSD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACMSD
    Sirion Biotech Customized adenovirus for overexpression of ACMSD

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ACMSD (see all 7)
    OriGene ORF clones in mouse, rat for ACMSD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACMSD (NM_138326)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACMSD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACMSD
    Sirion Biotech Customized lentivirus for stable overexpression of ACMSD 
                         Customized lentivirus expression plasmids for stable overexpression of ACMSD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACMSD
    Search LifeMap BioReagents cell lines for ACMSD
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACMSD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACMSD About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    tryptophan degradation III (eukaryotic)0.50
    Tryptophan catabolism0.45
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4tryptophan utilization II
    tryptophan utilization II0.70
    tryptophan utilization I0.70
    5Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for ACMSD
        Tryptophan metabolism
    tryptophan degradation III (eukaryotic)
    2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA
    tryptophan utilization II
    tryptophan utilization I

    3        Reactome Pathways for ACMSD
        Tryptophan catabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for ACMSD):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: ACMSD_HUMAN, Q8TDX5
    Pathway: Secondary metabolite metabolism; quinolate metabolism


    ACMSD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACMSD

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ACMSD (Q8TDX52, 3 ENSP000003484594) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-67614 I2D: score=4 STRING: ENSP00000347358
    HAAOENSP000002949734STRING: ENSP00000294973
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006569tryptophan catabolic process TAS--
    GO:0008152metabolic process ----
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046874quinolinate metabolic process IDA12140278

    ACMSD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACMSD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACMSD

    4 HMDB Compounds for ACMSD    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Amino-3-carboxymuconic acid semialdehydeACS (see all 9)16597-58-3--
    2-Aminomuconic acid2-Aminomuconate (see all 5)4548-99-6--
    2-Aminomuconic acid semialdehyde2-Aminomuconate 6-semialdehyde (see all 3)245128-91-0--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--

    10 Novoseek inferred chemical compound relationships for ACMSD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-amino-3-carboxymuconate-6-semialdehyde 98.5 16 11802786 (2), 15206762 (2), 17288562 (2), 15466039 (1) (see all 5)
    2-nitrobenzoic acid 88.2 1 16131206 (1)
    3-hydroxyanthranilic acid 88.1 1 10966936 (1)
    quinolinic acid 85.2 14 15206762 (3), 15229365 (2), 12140278 (2), 16939194 (1) (see all 6)
    picolinic acid 82.5 2 19843166 (1)
    kynurenine 70.3 1 10966936 (1)
    cobalt 52.4 1 19081971 (1)
    niacin 50 1 8866254 (1)
    quinine 47.9 1 15246871 (1)
    acetyl-coa 47.5 2 15229365 (1), 16939194 (1)

    Search CenterWatch for drugs/clinical trials and news about ACMSD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACMSD gene: 
    NM_138326.2  

    Unigene Cluster for ACMSD:

    Aminocarboxymuconate semialdehyde decarboxylase
    Hs.655728  [show with all ESTs]
    Unigene Representative Sequence: AK125008
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356140(uc002ttz.3) ENST00000485893 ENST00000392928(uc002tua.3)
    ENST00000498093 ENST00000283054

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACMSD
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ACMSD:
    hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidACMSD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACMSD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACMSD
    Clone
    Products:
         
    OriGene clones in human, mouse for ACMSD (see all 7)
    OriGene ORF clones in mouse, rat for ACMSD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACMSD (NM_138326)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACMSD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACMSD
    Sirion Biotech Customized lentivirus for stable overexpression of ACMSD 
                         Customized lentivirus expression plasmids for stable overexpression of ACMSD 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACMSD
    OriGene qSTAR qPCR primer pairs in human, mouse for ACMSD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACMSD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACMSD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACMSD

    Additional mRNA sequence: 

    AB071418.1 AK125008.1 BC016018.1 BC107420.1 

    5 DOTS entries:

    DT.95367327  DT.110757  DT.91994451  DT.101591  DT.75193412 

    24/37 AceView cDNA sequences (see all 37):

    AB071418 AW025340 BX106606 BC016018 BI759827 AK125008 AA770062 AW296086 
    AA702020 AA862426 R06001 BG402220 N67609 AW028479 BI765661 AL700060 
    AA865292 AI695273 BG428338 BG567318 NM_138326 AI084813 BG427004 BG399101 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ACMSD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
    SP1:                                      -                                   -               
    SP2:                    -                                                     -               
    SP3:                    -                                                                     
    SP4:                                      -                                                   


    ECgene alternative splicing isoforms for ACMSD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACMSD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAATTTG
    ACMSD Expression
    About this image


    See ACMSD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACMSD

    SOURCE GeneReport for Unigene cluster: Hs.655728
        SABiosciences Expression via Pathway-Focused PCR Array including ACMSD: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACMSD
    OriGene qSTAR qPCR primer pairs in human, mouse for ACMSD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACMSD
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACMSD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACMSD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACMSD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACMSD gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acmsd1 , 5 amino carboxymuconate semialdehyde decarboxylase1, 5 86.51(n)1
    87.2(a)1
      1 (55.80 cM)5
    2666451  NM_001033041.21  NP_001028213.11 
     1277294135 
    chicken
    (Gallus gallus)
    Aves ACMSD1 aminocarboxymuconate semialdehyde decarboxylase 75.99(n)
    80.65(a)
      424288  XM_422133.3  XP_422133.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACMSD6
    Uncharacterized protein
    79(a)
    1 ↔ 1
    1(96416770-96445546)
    zebrafish
    (Danio rerio)
    Actinopterygii acmsd1 aminocarboxymuconate semialdehyde decarboxylase 73.21(n)
    81.25(a)
      557166  NM_001089494.1  NP_001082963.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71D11A.31 Protein Y71D11A.3 55.42(n)
    51.98(a)
      175280  NM_064935.6  NP_497336.3 


    ENSEMBL Gene Tree for ACMSD (if available)
    TreeFam Gene Tree for ACMSD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/531 SNPs in ACMSD are shown (see all 531)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs621714431,2
    C--135594221(+) GACTTT/CCCAGC 1 -- us2k14Minor allele frequency- C:0.28NA WA EA 360
    rs621714441,2
    C,F--135594399(+) TTCTCA/CGAGAA 1 -- us2k15Minor allele frequency- C:0.13NA WA EA 362
    rs1821876551,2
    --135594408(+) AAAATG/TGTTAT 1 -- us2k10--------
    rs792176491,2
    C,F--135594436(+) CCTCAT/GAGTGA 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1388025951,2
    --135594467(+) TCCCTC/GTTTTT 1 -- us2k10--------
    rs1428252301,2
    C--135594545(+) AATGAA/GGGCAT 1 -- us2k10--------
    rs779187061,2
    C,F--135594661(+) TTCTCC/TCACAC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs752178111,2
    F--135594668(+) ACACAC/TTATTG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs19548741,2
    C,F,A,H--135594699(+) ttctcT/Cgtgct 1 -- us2k121Minor allele frequency- C:0.36NS EA WA NA CSA 2342
    rs1875804551,2
    --135594763(+) ATGTTA/GTGAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACMSD (135596117 - 135659604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACMSD:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672210CNV Deletion23128226
    esv268160CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ACMSD
    DNA2.0 Custom Variant and Variant Library Synthesis for ACMSD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608889    OMIM disorders: --

    3 diseases for ACMSD:    About MalaCards
    parkinson's disease    neuronitis    hepatitis


    ACMSD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ACMSD
    Human Genome Epidemiology (HuGE) Navigator: ACMSD (1 document)

    Export disorders for ACMSD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACMSD gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ACMSD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and expression of a cDNA encoding human alpha-amino- beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'. (PubMed id 12140278)1, 2, 3, 9 Fukuoka S.... Shibata K. (2002)
    2. The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis. (PubMed id 19843166)1, 2, 9 Garavaglia S.... Rizzi M. (2009)
    3. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide associat ion studies. (PubMed id 21292315)1, 4  ....Wood N.W. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    6. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Identification and expression of alpha cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): a key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis. (PubMed id 15206762)9 Fukuoka S....Shibata K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 130013 HGNC: 19288 AceView: ACMSD Ensembl:ENSG00000153086 euGenes: HUgn130013
    ECgene: ACMSD Kegg: 130013 H-InvDB: ACMSD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACMSD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACMSD gene:
    Search GeneIP for patents involving ACMSD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACMSD   OriGene RNAi products in human, mouse, rat for ACMSD  
     OriGene qPCR primer pairs and template standards for ACMSD   OriGene Protein Over-expression Lysate for ACMSD  
     OriGene MassSpec something-or-other for ACMSD   OriGene clones in human, mouse for ACMSD  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACMSD   OriGene Purified Protein for ACMSD  
     OriGene ORF clones in mouse, rat for ACMSD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACMSD   OriGene Custom Protein Services for ACMSD  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACMSD
     QIAGEN SeqTarget long-range PCR primers for resequencing ACMSD
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACMSD
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACMSD
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACMSD
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACMSD
     GenScript Custom Purified and Recombinant Proteins Services for ACMSD GenScript cDNA clones with any tag delivered in your preferred vector for ACMSD
     GenScript Custom Assay Services for ACMSD GenScript Custom Superior Antibodies Services for ACMSD
     GenScript Custom overexpressing Cell Line Services for ACMSD CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACMSD promoter
     Search Chromatin IP Primers for ACMSD
     RT2 qPCR Primer Assay in human, mouse, rat ACMSD
     Search GNC Networks for ACMSD
     SABiosciences PCR Arrays including human, mouse, rat ACMSD
     Search Tocris compounds for ACMSD
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ACMSD antibodies
     ACMSD proteins
     ACMSD lysates
     Antibodies for ACMSD
     See all of Abcam's Antibodies, Kits and Proteins for ACMSD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ACMSD
     Antibodies for ACMSD
     ELISAs for ACMSD
     CLIAs for ACMSD
     Search LifeMap BioReagents cell lines for ACMSD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACMSD
     SwitchGear 3'UTR luciferase reporter plasmids for ACMSD
     SwitchGear Promoter luciferase reporter plasmids for ACMSD
     ThermoFisher Antibody for ACMSD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACMSD
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ACMSD
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACMSD
    Customized:
     lentivirus for stable overexpression of ACMSD
     lentivirus expression plasmids for stable overexpression of ACMSD
     adenovirus for overexpression of ACMSD
     LSBio Antibodies in human, mouse, rat for ACMSD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACMSD gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4