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ACLY Gene

protein-coding   GIFtS: 69
GCID: GC17M040023

ATP Citrate Lyase

Microbiology & Infectious Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP Citrate Lyase1 2     EC 2.3.3.83 8
ATP Citrate Synthase1 2     ATPCL2
Citrate Cleavage Enzyme2 3     CLATP2
ACL2 3     ATP-Citrate Synthase2
ATP-Citrate (Pro-S-)-Lyase2 3     

External Ids:    HGNC: 1151   Entrez Gene: 472   Ensembl: ENSG000001314737   OMIM: 1087285   UniProtKB: P533963   

Export aliases for ACLY gene to outside databases

Previous GC identifers: GC17M039579 GC17M042174 GC17M039931 GC17M040396 GC17M037276 GC17M035785


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACLY Gene:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The
enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It
catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP
to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including
lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of
acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for ACLY Gene:
ACLY (ATP citrate lyase) is a protein-coding gene. Diseases associated with ACLY include type 1 diabetes mellitus, and type 1 diabetes. GO annotations related to this gene include ATP citrate synthase activity and cofactor binding. An important paralog of this gene is SUCLG1.

UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396
Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many
tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis
of acetylcholine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACLY gene promoter:
         Max1   c-Myc   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACLY promoter sequence
   Search Chromatin IP Primers for ACLY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACLY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

ACLY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACLY gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040023:  view genomic region     (about GC identifiers)

Start:
40,023,161 bp from pter      End:
40,086,795 bp from pter
Size:
63,635 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 153,568-205,661     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396 (See protein sequence)
Recommended Name: ATP-citrate synthase  
Size: 1101 amino acids; 120839 Da
Cofactor: Magnesium
Subunit: Homotetramer
3 PDB 3D structures from and Proteopedia for ACLY:
3MWD (3D)        3MWE (3D)        3PFF (3D)    
Secondary accessions: B4DIM0 Q13037 Q9BRL0
Alternative splicing: 2 isoforms:  P53396-1   P53396-2   

Explore the universe of human proteins at neXtProt for ACLY: NX_P53396

Explore proteomics data for ACLY at MOPED

Post-translational modifications: 

  • ISGylated1
  • Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the
    protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis.
    Deacetylated by SIRT21
  • Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably
    inhibited by acetylation at same site (Probable)1
  • Ubiquitination2 at Lys4, Lys12, Lys17, Lys58, Lys64, Lys68, Lys82, Lys97, Lys148, Lys151,
                                 Lys230, Lys232, Lys259, Lys265, Lys272, Lys488, Lys498, Lys630, Lys650, Lys780 (see all 27)
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACLY (P53396) (see all 30)
     KQGLYRH  WCIGTCA  FTYLEINP  TTDGVYEG 


    See ACLY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001087.2  NP_942127.1  

    ENSEMBL proteins: 
     ENSP00000253792   ENSP00000466259   ENSP00000445349   ENSP00000377474   ENSP00000464717  
     ENSP00000468705   ENSP00000345398  
    Reactome Protein details: P53396

    ACLY Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACLY
    OriGene Protein Over-expression Lysate for ACLY
    OriGene MassSpec for ACLY
    OriGene Custom Protein Services for ACLY
    GenScript Custom Purified and Recombinant Proteins Services for ACLY
    Novus Biologicals ACLY Lysate
    Sino Biological Recombinant Protein for ACLY
    Sino Biological Cell Lysate for ACLY
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACLY

    ACLY Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ACLY 
    OriGene Antibodies for ACLY
    OriGene Custom Antibody Services for ACLY
    Novus Biologicals ACLY Antibodies
    Abcam antibodies for ACLY
    Cloud-Clone Corp. Antibodies for ACLY
    ThermoFisher Antibody for ACLY
    LSBio Antibodies in human, mouse, rat for ACLY

    ACLY Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACLY
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACLY
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACLY
    Cloud-Clone Corp. CLIAs for ACLY


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 13):
     IPR013650 ATP-grasp_succ-CoA_synth-type
     IPR014608 ATP-citrate_synthase
     IPR005811 CoA_ligase
     IPR016141 Citrate_synthase-like_core
     IPR017866 Succ-CoA_synthase_bsu_CS

    Graphical View of Domain Structure for InterPro Entry P53396

    ProtoNet protein and cluster: P53396

    2 Blocks protein domains:
    IPB003781 CoA Binding Domain
    IPB005809 Succinyl-CoA synthetase


    UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396
    Similarity: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family
    Similarity: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family
    Similarity: Contains 1 ATP-grasp domain


    ACLY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACLY_HUMAN, P53396
    Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many
    tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis
    of acetylcholine
    Catalytic activity: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA

         Genatlas biochemistry entry for ACLY:
    ATP-citrate lyase,catalyzing the synthesis of the cytosolic acetyl-CoA,used as a substrate for de novo
    biosynthesis of fatty acid and cholesterol

         Enzyme Number (IUBMB): EC 2.3.3.81 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0003878ATP citrate synthase activity TAS--
    GO:0004775succinate-CoA ligase (ADP-forming) activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    ACLY for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Acly):
     homeostasis/metabolism  mortality/aging 

    ACLY for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACLY
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACLY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACLY
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACLY

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACLY:
    hsa-mir-92a-3p (MIRT049373), hsa-mir-877-3p (MIRT037071), hsa-mir-18a-3p (MIRT040866), hsa-mir-149-5p (MIRT045416), hsa-mir-10a-3p (MIRT038673), hsa-mir-324-3p (MIRT042918), hsa-mir-93-3p (MIRT038850), hsa-mir-10b-5p (MIRT047450), hsa-mir-320b (MIRT036222), hsa-mir-361-5p (MIRT044080), hsa-mir-125b-5p (MIRT045906), hsa-mir-1229-3p (MIRT036343), hsa-mir-769-3p (MIRT039123), hsa-mir-484 (MIRT042069)

    Block miRNA regulation of human, mouse, rat ACLY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACLY (see all 14):
    hsa-miR-194* hsa-miR-22 hsa-miR-513a-5p hsa-miR-27a hsa-miR-3120-3p hsa-miR-374c hsa-miR-214 hsa-miR-567
    SwitchGear 3'UTR luciferase reporter plasmidACLY 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACLY
    Predesigned siRNA for gene silencing in human, mouse, rat ACLY

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACLY

    Clone
    Products:
         
    OriGene clones in human, mouse for ACLY (see all 12)
    OriGene ORF clones in mouse, rat for ACLY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACLY (NM_198830)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACLY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACLY

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACLY
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACLY 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACLY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACLY_HUMAN, P53396: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane4
    mitochondrion2
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    ACLY for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACLY About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Integration of energy metabolism
    Integration of energy metabolism0.75
    acetyl-CoA biosynthesis III (from citrate)0.00
    ChREBP activates metabolic gene expression0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Triglyceride Biosynthesis
    Triglyceride Biosynthesis
    Fatty Acyl-CoA Biosynthesis0.00
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    5Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ACLY
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for ACLY
        Regulation of lipid metabolism Insulin signaling-generic cascades

    3 BioSystems Pathways for ACLY
        SREBP signalling
    Fatty Acid Biosynthesis
    acetyl-CoA biosynthesis III (from citrate)


    2 Reactome Pathways for ACLY
        ChREBP activates metabolic gene expression
    Fatty Acyl-CoA Biosynthesis


    2 Kegg Pathways  (Kegg details for ACLY):
        Citrate cycle (TCA cycle)
    Metabolic pathways


    ACLY for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACLY: 
              Cancer PathwayFinder in human mouse rat
              Fatty Liver in human mouse rat
              Diabetes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ACLY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACLY (P533962, 3 ENSP000002537924) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    PSMB1P206183, ENSP000002621934I2D: score=5 STRING: ENSP00000262193
    GSK3BP498413, ENSP000003248064I2D: score=4 STRING: ENSP00000324806
    NME1-NME2P223923I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006101citrate metabolic process TAS1371749
    GO:0006112energy reserve metabolic process TAS--
    GO:0006200ATP catabolic process TAS1371749
    GO:0008152metabolic process ----
    GO:0008610lipid biosynthetic process IDA--

    ACLY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ACLY
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACLY

    7 HMDB Compounds for ACLY    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Citric acid2-Hydroxy-1,2,3-propanetricarboxylate (see all 20)77-92-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Oxalacetic acid2-Ketosuccinate (see all 20)328-42-7--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    Selected Novoseek inferred chemical compound relationships for ACLY gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxycitrate 91 4 17476502 (1), 11319829 (1), 20372858 (1)
    (-)-hydroxycitrate 89.1 3 2176080 (1), 11101469 (1)
    acetyl-coa 84 26 14681844 (2), 8207683 (1), 7911658 (1), 11171136 (1) (see all 21)
    citrate 77.7 31 17928289 (2), 1765100 (2), 8207683 (1), 9820262 (1) (see all 21)
    oxaloacetate 69.9 7 7669753 (2), 11171137 (1), 1675605 (1), 18922930 (1)
    phosphohistidine 69.2 2 1371749 (1)
    pyruvate 62.2 14 8999918 (3), 17928289 (2), 11171136 (1), 7616129 (1) (see all 10)
    fatty acid 62.1 26 10410463 (3), 8999918 (3), 15869874 (1), 17476502 (1) (see all 15)
    6-phosphogluconate 60.9 2 14605988 (1), 8355562 (1)
    3-hydroxy-3-methylglutaryl-coa 57.8 7 8999918 (2), 18774944 (1), 19389950 (1)



    ACLY for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ACLY gene (2 alternative transcripts): 
    NM_001096.2  NM_198830.1  

    Unigene Cluster for ACLY:

    ATP citrate lyase
    Hs.387567  [show with all ESTs]
    Unigene Representative Sequence: NM_001096
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352035(uc002hyg.3 uc002hyi.3) ENST00000590151 ENST00000537919
    ENST00000393896 ENST00000588779 ENST00000590770 ENST00000588547 ENST00000590735
    ENST00000592970 ENST00000353196(uc002hyh.3 uc010wfx.2 uc010wfy.2)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACLY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACLY (see all 14):
    hsa-miR-194* hsa-miR-22 hsa-miR-513a-5p hsa-miR-27a hsa-miR-3120-3p hsa-miR-374c hsa-miR-214 hsa-miR-567
    SwitchGear 3'UTR luciferase reporter plasmidACLY 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACLY
    Predesigned siRNA for gene silencing in human, mouse, rat ACLY
    Clone
    Products:
         
    OriGene clones in human, mouse for ACLY (see all 12)
    OriGene ORF clones in mouse, rat for ACLY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACLY (NM_198830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACLY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACLY
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACLY
    OriGene qSTAR qPCR primer pairs in human, mouse for ACLY
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACLY
      QuantiTect SYBR Green Assays in human, mouse, rat ACLY
      QuantiFast Probe-based Assays in human, mouse, rat ACLY

    Additional mRNA sequence: 

    AB210035.1 AK058079.1 AK095084.1 AK295675.1 AK304802.1 AK312315.1 BC006195.2 U18197.1 
    X64330.1 

    22 DOTS entries:

    DT.40188466  DT.100820527  DT.100665906  DT.100820535  DT.91760382  DT.120917271  DT.100642777  DT.120917233 
    DT.95161296  DT.86850803  DT.95211622  DT.101977534  DT.120917265  DT.120917268  DT.91652223  DT.91760383 
    DT.91808785  DT.95161274  DT.95161295  DT.95359867  DT.97862140  DT.91697249 

    Selected AceView cDNA sequences (see all 523):

    AV681852 AW467008 BQ423941 AI697052 BQ720522 AI364214 BC006195 BU192899 
    BE779900 AW874633 CD610605 NM_001096 BM725670 AA300641 AW304332 AI906366 
    AI699623 BU508688 AI417300 BQ678057 BQ430304 AL555535 BQ426036 BP364222 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACLY (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^
    SP1:                                                                                                                          -                             -   
    SP2:                                                                                                                          -                             -   
    SP3:                                                                                                                    -     -                             -   
    SP4:                          -     -     -                                                                                                                     
    SP5:                                                                                                                                                        -   

    ExUns: 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
    SP1:                                                              -                                             
    SP2:                                                              -                                             
    SP3:                                                              -                                             
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ACLY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ACLY expression in normal human tissues (normalized intensities)      ACLY embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAACATTG
    ACLY Expression
    About this image


    ACLY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
    ACLY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACLY Protein Expression

    Genevestigator expression for ACLY

    SOURCE GeneReport for Unigene cluster: Hs.387567
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACLY: 
              Cancer PathwayFinder in human mouse rat
              Fatty Liver in human mouse rat
              Diabetes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACLY gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acly1 , 5 ATP citrate lyase1, 5 90.25(n)1
    98.09(a)1
      11 (63.47 cM)5
    1041121  NM_001199296.11  NP_001186225.11 
     1004763535 
    chicken
    (Gallus gallus)
    Aves ACLY1 ATP citrate lyase 80.23(n)
    93.19(a)
      395373  NM_001030540.1  NP_001025711.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACLY6
    ATP citrate lyase
    88(a)
    1 ↔ 1
    6(66483805-66551297)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.119812 Xenopus laevis transcribed sequence with strong similarity to protein pirS21173 (H.sapiens) S21173 ATP citrate (pro-S)-lyase - human less 79.63(n)    BX846323.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aclya1 ATP citrate lyase a 76.75(n)
    87.17(a)
      436922  NM_001002649.1  NP_001002649.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ATPCL1 , 3 acetyl-CoA biosynthesis ATP-citrate
    (pro-S)-lyase less3
    ATP citrate lyase1
    67(a)3
    66.45(n)1
    70.55(a)1
      367601  NM_166131.21  NP_725514.21 
    worm
    (Caenorhabditis elegans)
    Secernentea B0365.13
    acly-21
    ATP citrate lyase3
    acly-21
    59(a)
    (best of 2)3
    58.32(n)1
    62.52(a)1
      V(13119107-13122639)3
    1797951  NM_073866.31  NP_506267.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LSC16
    Alpha subunit of succinyl-CoA ligase, which is a m...
    25(a)
    1 → many
    XV(593057-594046) YOR142W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACLB-11 ACLB-1 56.91(n)
    53.58(a)
      819845  NM_111541.3  NP_187317.1 
    rice
    (Oryza sativa)
    Liliopsida Os.87302 Oryza sativa (japonica cultivar-group) cDNA cloneJ013055I05, full insert sequence less 74.74(n)    AK062011.1 


    ENSEMBL Gene Tree for ACLY (if available)
    TreeFam Gene Tree for ACLY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACLY gene
    SUCLG12  
    1 SIMAP similar gene for ACLY using alignment to 4 protein entries:     ACLY_HUMAN (see all proteins):
    ACLY variant protein

    ACLY for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACLY (see all 1092)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105793541,2
    C--35801806(+) ttttt-/T/TTT 
            
    gagac
    2 -- int11NA 2
    rs753439711,2
    C--40023007(-) AACTCG/AGCCTC 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1899513961,2
    C--40023710(+) AAAAAA/GTGTTT 2 -- ut310--------
    rs1422505791,2
    --40023730(+) AAAAAC/GAAAGC 2 -- ut310--------
    rs733077291,2
    C,F--40023926(+) TCTTCG/AGTGCC 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs1158449621,2
    C--40024021(+) GGAAGA/CGATCT 2 -- ut311Minor allele frequency- C:0.01WA 118
    rs72172181,2
    C,A,H--40024023(+) AAGAGT/ATCTTG 2 -- ut31 ese3 trp312Minor allele frequency- A:0.08NA WA CSA EA 376
    rs2003153981,2
    --40024051(+) TAGGGC/TTCCTG 2 -- ut310--------
    rs1129351541,2
    C--40024159(+) TGTCCA/TAAAAT 2 -- spa10--------
    rs1997064311,2
    C--40024167(+) AATGAA/TGCAAA 2 -- int11Minor allele frequency- T:0.00EU 1323

    HapMap Linkage Disequilibrium report for ACLY (40023161 - 40086795 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACLY:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833447CNV Loss17160897
    nsv908238CNV Loss21882294

    Human Gene Mutation Database (HGMD): ACLY
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACLY
    DNA2.0 Custom Variant and Variant Library Synthesis for ACLY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 108728    OMIM disorders: --

    18 diseases for ACLY:    About MalaCards
    type 1 diabetes mellitus    type 1 diabetes    labyrinthitis    diabetes mellitus
    obesity    schizophrenia    ovarian cancer    hepatocellular carcinoma
    cervicitis    thyroiditis    lung cancer    prostate cancer
    pancreatitis    prostatitis    hepatitis    malaria
    cerebritis    neuronitis


    ACLY for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ACLY gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 16226706 (1), 18922930 (1), 18796435 (1)
    cancer 0 3 16778563 (2), 20372858 (1)

    Genetic Association Database (GAD): ACLY
    Human Genome Epidemiology (HuGE) Navigator: ACLY (6 documents)

    Export disorders for ACLY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACLY gene, integrated from 10 sources (see all 157):
    (articles sorted by number of sources associating them with ACLY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a human ATP-citrate lyase cDNA. (PubMed id 1371749)1, 2, 3, 9 Elshourbagy N.A.... Gloger I.S. (Eur. J. Biochem. 1992)
    2. Localization of the gene for ATP citrate lyase (ACLY) distal to gastrin(GAS) and proximal to D17S856 on chromosome 17q12-q21. (PubMed id 8088842)1, 3, 9 Couch F.J....Weber B.L. (Genomics 1994)
    3. ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. (PubMed id 22102020)1, 2 Sun T....Fraser M.E. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography. (PubMed id 20558738)1, 2 Sun T.... Fraser M.E. (J. Biol. Chem. 2010)
    7. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    8. Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes. (PubMed id 18681781)1, 4 Srivastava V....Thelma B. (Pharmacogenomics 2008)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 47 HGNC: 115 AceView: ACLY Ensembl:ENSG00000131473 euGenes: HUgn47
    ECgene: ACLY Kegg: 47 H-InvDB: ACLY

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACLY Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACLY Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACLY gene:
    Search GeneIP for patents involving ACLY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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