Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACLY Gene

Aliases for ACLY Gene

  • ATP Citrate Lyase 2 3
  • ATP-Citrate (Pro-S-)-Lyase 3 4
  • Citrate Cleavage Enzyme 3 4
  • ATP Citrate Synthase 2 3
  • EC 2.3.3.8 4 64
  • ACL 3 4
  • ATP-Citrate Synthase 3
  • ATPCL 3
  • CLATP 3

External Ids for ACLY Gene

Summaries for ACLY Gene

Entrez Gene Summary for ACLY Gene

  • ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for ACLY Gene

ACLY (ATP Citrate Lyase) is a Protein Coding gene. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include cofactor binding and ATP citrate synthase activity. An important paralog of this gene is SUCLG1.

UniProtKB/Swiss-Prot for ACLY Gene

  • ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACLY Gene

Genomics for ACLY Gene

Genomic Location for ACLY Gene

Start:
41,866,908 bp from pter
End:
41,930,542 bp from pter
Size:
63,635 bases
Orientation:
Minus strand

Genomic View for ACLY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACLY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACLY Gene

Regulatory Elements for ACLY Gene

Proteins for ACLY Gene

  • Protein details for ACLY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53396-ACLY_HUMAN
    Recommended name:
    ATP-citrate synthase
    Protein Accession:
    P53396
    Secondary Accessions:
    • B4DIM0
    • B4E3P0
    • Q13037
    • Q9BRL0

    Protein attributes for ACLY Gene

    Size:
    1101 amino acids
    Molecular mass:
    120839 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for ACLY Gene

    Alternative splice isoforms for ACLY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACLY Gene

Proteomics data for ACLY Gene at MOPED

Post-translational modifications for ACLY Gene

  • Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.
  • ISGylated.
  • Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys4, Lys12, Lys17, Lys58, Lys64, Lys68, Lys82, Lys97, Lys148, Lys151, Lys230, Lys232, Lys259, Lys265, Lys272, Lys488, Lys498, Lys630, Lys650, Lys780, Lys836, Lys918, Lys944, Lys948, Lys991, Lys1077, Lys1080, and Lys471

Other Protein References for ACLY Gene

Domains for ACLY Gene

UniProtKB/Swiss-Prot:

ACLY_HUMAN
Domain:
  • Contains 1 ATP-grasp domain.:
    • P53396
Family:
  • In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.:
    • P53396
  • In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.:
    • P53396
genes like me logo Genes that share domains with ACLY: view

No data available for Gene Families for ACLY Gene

Function for ACLY Gene

Molecular function for ACLY Gene

GENATLAS Biochemistry: ATP-citrate lyase,catalyzing the synthesis of the cytosolic acetyl-CoA,used as a substrate for de novo biosynthesis of fatty acid and cholesterol
UniProtKB/Swiss-Prot CatalyticActivity: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation results in a 6-fold increase in V(max) and the conversion of citrate dependence from sigmoidal to hyperbolic. Fructose 6-phosphate (F6P) is also a potent activator.
UniProtKB/Swiss-Prot Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Enzyme Numbers (IUBMB) for ACLY Gene

Gene Ontology (GO) - Molecular Function for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003878 ATP citrate synthase activity TAS 23932781
GO:0004775 succinate-CoA ligase (ADP-forming) activity IEA --
GO:0005515 protein binding IPI 23932781
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACLY: view

Phenotypes for ACLY Gene

genes like me logo Genes that share phenotypes with ACLY: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACLY Gene

Localization for ACLY Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACLY Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACLY Gene COMPARTMENTS Subcellular localization image for ACLY gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACLY: view

Pathways for ACLY Gene

genes like me logo Genes that share pathways with ACLY: view

Pathways by source for ACLY Gene

Gene Ontology (GO) - Biological Process for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006101 citrate metabolic process TAS 1371749
GO:0006112 energy reserve metabolic process TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0008152 metabolic process --
GO:0008610 lipid biosynthetic process IDA 23932781
genes like me logo Genes that share ontologies with ACLY: view

Compounds for ACLY Gene

(7) HMDB Compounds for ACLY Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Citric acid
  • 2-Hydroxy-1,2,3-propanetricarboxylate
77-92-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0

(28) Novoseek inferred chemical compound relationships for ACLY Gene

Compound -log(P) Hits PubMed IDs
hydroxycitrate 91 3
(-)-hydroxycitrate 89.1 2
acetyl-coa 84 22
citrate 77.7 23
oxaloacetate 69.9 5
genes like me logo Genes that share compounds with ACLY: view

Transcripts for ACLY Gene

Unigene Clusters for ACLY Gene

ATP citrate lyase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACLY Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - -
SP8:
SP9:

Relevant External Links for ACLY Gene

GeneLoc Exon Structure for
ACLY
ECgene alternative splicing isoforms for
ACLY

Expression for ACLY Gene

mRNA expression in normal human tissues for ACLY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACLY Gene

SOURCE GeneReport for Unigene cluster for ACLY Gene Hs.387567

genes like me logo Genes that share expressions with ACLY: view

Orthologs for ACLY Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACLY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACLY 36
  • 98.89 (n)
  • 99.22 (a)
ACLY 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACLY 36
  • 91.87 (n)
  • 98.53 (a)
ACLY 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACLY 36
  • 91.67 (n)
  • 98.18 (a)
ACLY 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acly 36
  • 90.25 (n)
  • 98.09 (a)
Acly 16
Acly 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACLY 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACLY 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acly 36
  • 90.25 (n)
  • 98.09 (a)
chicken
(Gallus gallus)
Aves ACL 37
  • 94 (a)
OneToOne
ACLY 36
  • 80.23 (n)
  • 93.19 (a)
lizard
(Anolis carolinensis)
Reptilia ACLY 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11981 36
tropical clawed frog
(Silurana tropicalis)
Amphibia acly 36
  • 78.86 (n)
  • 91.2 (a)
Str.7236 36
zebrafish
(Danio rerio)
Actinopterygii aclya 36
  • 76.75 (n)
  • 87.17 (a)
aclya 37
  • 87 (a)
OneToMany
aclyb 37
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010156 36
  • 64.22 (n)
  • 70.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta ATPCL 36
  • 66.45 (n)
  • 70.55 (a)
ATPCL 37
  • 69 (a)
OneToOne
ATPCL 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea acly-2 36
  • 58.32 (n)
  • 62.52 (a)
acly-2 37
  • 61 (a)
OneToMany
D1005.1 37
  • 60 (a)
OneToMany
D1005.1 38
  • 58 (a)
B0365.1 38
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSC1 37
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACLB-1 36
  • 56.91 (n)
  • 53.58 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4574 36
rice
(Oryza sativa)
Liliopsida Os.8730 36
Os01g0300200 36
  • 55.13 (n)
  • 53.91 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.15086 36
bread mold
(Neurospora crassa)
Ascomycetes NCU06785 36
  • 64.01 (n)
  • 64.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1703.07 36
  • 60.72 (n)
  • 64.98 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5723 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 69 (a)
OneToOne
Species with no ortholog for ACLY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACLY Gene

ENSEMBL:
Gene Tree for ACLY (if available)
TreeFam:
Gene Tree for ACLY (if available)

Paralogs for ACLY Gene

Paralogs for ACLY Gene

Selected SIMAP similar genes for ACLY Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ACLY: view

Variants for ACLY Gene

Sequence variations from dbSNP and Humsavar for ACLY Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs878892 -- 41,913,489(-) CAAAC(G/T)GGTGT intron-variant
rs893009 -- 41,908,198(+) AGACT(C/T)TGCCC intron-variant
rs1058875 -- 41,912,479(-) GGGTC(A/G)ACCTC reference, missense
rs1136262 -- 41,910,235(-) CTTCG(C/T)CCCCC missense, reference
rs1136263 -- 41,898,658(-) AACTT(C/T)CTCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ACLY Gene

Variant ID Type Subtype PubMed ID
nsv833447 CNV Loss 17160897
nsv908238 CNV Loss 21882294

Relevant External Links for ACLY Gene

HapMap Linkage Disequilibrium report
ACLY
Human Gene Mutation Database (HGMD)
ACLY

Disorders for ACLY Gene

(2) Novoseek inferred disease relationships for ACLY Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3
cancer 0 3

Relevant External Links for ACLY

Genetic Association Database (GAD)
ACLY
Human Genome Epidemiology (HuGE) Navigator
ACLY
genes like me logo Genes that share disorders with ACLY: view

No data available for UniProtKB/Swiss-Prot for ACLY Gene

Publications for ACLY Gene

  1. Cloning and expression of a human ATP-citrate lyase cDNA. (PMID: 1371749) Elshourbagy N.A. … Gloger I.S. (Eur. J. Biochem. 1992) 2 3 4 23
  2. Localization of the gene for ATP citrate lyase (ACLY) distal to gastrin(GAS) and proximal to D17S856 on chromosome 17q12-q21. (PMID: 8088842) Couch F.J. … Weber B.L. (Genomics 1994) 2 3 23
  3. Sequence of sites on ATP-citrate lyase and phosphatase inhibitor 2 phosphorylated by multifunctional protein kinase (a glycogen synthase kinase 3 like kinase). (PMID: 2176822) Ramakrishna S. … Benjamin W.B. (Biochemistry 1990) 3 23
  4. The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. (PMID: 14681844) Michno A. … Szutowicz A. (Metab. Clin. Exp. 2004) 3 23
  5. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer. (PMID: 18922930) Migita T. … Ishikawa Y. (Cancer Res. 2008) 3 23

Products for ACLY Gene

Sources for ACLY Gene

Back to Top

Content