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Aliases for ACLY Gene

Aliases for ACLY Gene

  • ATP Citrate Lyase 2 3 5
  • ATP-Citrate (Pro-S-)-Lyase 3 4
  • Citrate Cleavage Enzyme 3 4
  • EC 2.3.3.8 4 61
  • ACL 3 4
  • ATP Citrate Synthase 2
  • ATP-Citrate Synthase 3
  • ATPCL 3
  • CLATP 3

External Ids for ACLY Gene

Previous GeneCards Identifiers for ACLY Gene

  • GC17M039579
  • GC17M042174
  • GC17M039931
  • GC17M040396
  • GC17M037276
  • GC17M040023
  • GC17M035785

Summaries for ACLY Gene

Entrez Gene Summary for ACLY Gene

  • ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for ACLY Gene

ACLY (ATP Citrate Lyase) is a Protein Coding gene. Diseases associated with ACLY include Acrocallosal Syndrome. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include cofactor binding and ATP citrate synthase activity. An important paralog of this gene is SUCLG1.

UniProtKB/Swiss-Prot for ACLY Gene

  • ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Tocris Summary for ACLY Gene

  • ATP citrate lyase (ATP citrate synthase, ACLY) is a transferase that catalyzes the conversion of citrate and coenzyme A to acetyl-CoA. ACLY is the key regulator between the high rates of aerobic glycolysis and de novo lipid synthesis exhibited in many types of tumor cells.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACLY Gene

Genomics for ACLY Gene

Regulatory Elements for ACLY Gene

Enhancers for ACLY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ACLY on UCSC Golden Path with GeneCards custom track

Promoters for ACLY Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ACLY Gene

Chromosome:
17
Start:
41,866,908 bp from pter
End:
41,930,542 bp from pter
Size:
63,635 bases
Orientation:
Minus strand

Genomic View for ACLY Gene

Genes around ACLY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACLY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACLY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACLY Gene

Proteins for ACLY Gene

  • Protein details for ACLY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53396-ACLY_HUMAN
    Recommended name:
    ATP-citrate synthase
    Protein Accession:
    P53396
    Secondary Accessions:
    • B4DIM0
    • B4E3P0
    • Q13037
    • Q9BRL0

    Protein attributes for ACLY Gene

    Size:
    1101 amino acids
    Molecular mass:
    120839 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for ACLY Gene

    Alternative splice isoforms for ACLY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACLY Gene

Post-translational modifications for ACLY Gene

  • Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.
  • ISGylated.
  • Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
  • Ubiquitination at Lys 4, Lys 12, Lys 17, Lys 58, Lys 64, Lys 68, Lys 82, Lys 97, Lys 148, Lys 151, Lys 230, Lys 232, Lys 265, Lys 272, Lys 488, Lys 498, Lys 630, Lys 650, Lys 780, Lys 836, Lys 918, Lys 944, Lys 948, Lys 991, Lys 1077, Lys 1080, and Lys 471
  • Modification sites at PhosphoSitePlus

Domains & Families for ACLY Gene

Suggested Antigen Peptide Sequences for ACLY Gene

Graphical View of Domain Structure for InterPro Entry

P53396

UniProtKB/Swiss-Prot:

ACLY_HUMAN :
  • Contains 1 ATP-grasp domain.
  • In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
Domain:
  • Contains 1 ATP-grasp domain.
Family:
  • In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
  • In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
genes like me logo Genes that share domains with ACLY: view

No data available for Gene Families for ACLY Gene

Function for ACLY Gene

Molecular function for ACLY Gene

GENATLAS Biochemistry:
ATP-citrate lyase,catalyzing the synthesis of the cytosolic acetyl-CoA,used as a substrate for de novo biosynthesis of fatty acid and cholesterol
UniProtKB/Swiss-Prot CatalyticActivity:
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation results in a 6-fold increase in V(max) and the conversion of citrate dependence from sigmoidal to hyperbolic. Fructose 6-phosphate (F6P) is also a potent activator.
UniProtKB/Swiss-Prot Function:
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Enzyme Numbers (IUBMB) for ACLY Gene

Gene Ontology (GO) - Molecular Function for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003878 ATP citrate synthase activity TAS 23932781
GO:0005515 protein binding IPI 23932781
GO:0005524 ATP binding TAS 1371749
GO:0046872 metal ion binding IEA --
GO:0048037 cofactor binding IEA --
genes like me logo Genes that share ontologies with ACLY: view
genes like me logo Genes that share phenotypes with ACLY: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACLY

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACLY Gene

Localization for ACLY Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACLY Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACLY Gene COMPARTMENTS Subcellular localization image for ACLY gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
mitochondrion 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACLY: view

Pathways & Interactions for ACLY Gene

genes like me logo Genes that share pathways with ACLY: view

Gene Ontology (GO) - Biological Process for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006085 acetyl-CoA biosynthetic process IDA 1371749
GO:0006101 citrate metabolic process IDA 1371749
GO:0006107 oxaloacetate metabolic process IDA 1371749
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006695 cholesterol biosynthetic process TAS 1371749
genes like me logo Genes that share ontologies with ACLY: view

No data available for SIGNOR curated interactions for ACLY Gene

Drugs & Compounds for ACLY Gene

(16) Drugs for ACLY Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
BMS-303141 Pharma ATP-citrate lyase inhibitor,potent, ATP citrate lyase inhibitor; orally bioavailable 0
Citric Acid Vet_approved Nutra Agonist, Activator 1063
ETC-1002 Pharma ACL inhibitor and AMPK activator 0

(21) Additional Compounds for ACLY Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Oxalacetic acid
  • 2-Ketosuccinate
  • 2-Ketosuccinic acid
  • 2-Oxobutanedioate
  • 2-Oxobutanedioic acid
  • 2-Oxosuccinate
328-42-7
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
SB 204990
154566-12-8

(2) Tocris Compounds for ACLY Gene

Compound Action Cas Number
BMS 303141 ATP citrate lyase inhibitor; orally bioavailable 943962-47-8
SB 204990 ATP citrate lyase (ACLY) inhibitor 154566-12-8

(2) ApexBio Compounds for ACLY Gene

Compound Action Cas Number
BMS-303141 ATP-citrate lyase inhibitor,potent 943962-47-8
ETC-1002 ACL inhibitor and AMPK activator
genes like me logo Genes that share compounds with ACLY: view

Transcripts for ACLY Gene

Unigene Clusters for ACLY Gene

ATP citrate lyase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACLY Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - -
SP8:
SP9:

Relevant External Links for ACLY Gene

GeneLoc Exon Structure for
ACLY
ECgene alternative splicing isoforms for
ACLY

Expression for ACLY Gene

mRNA expression in normal human tissues for ACLY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACLY Gene

This gene is overexpressed in Lymph node (7.6) and Bone marrow stromal cell (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACLY Gene



Protein tissue co-expression partners for ACLY Gene

NURSA nuclear receptor signaling pathways regulating expression of ACLY Gene:

ACLY

SOURCE GeneReport for Unigene cluster for ACLY Gene:

Hs.387567
genes like me logo Genes that share expression patterns with ACLY: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACLY Gene

Orthologs for ACLY Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACLY Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACLY 34
  • 91.87 (n)
  • 98.53 (a)
ACLY 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACLY 34
  • 91.67 (n)
  • 98.18 (a)
ACLY 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acly 34
  • 90.25 (n)
  • 98.09 (a)
Acly 16
Acly 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACLY 34
  • 98.89 (n)
  • 99.22 (a)
ACLY 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acly 34
  • 90.25 (n)
  • 98.09 (a)
oppossum
(Monodelphis domestica)
Mammalia ACLY 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACLY 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACLY 34
  • 80.23 (n)
  • 93.19 (a)
ACL 35
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACLY 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acly 34
  • 78.86 (n)
  • 91.2 (a)
Str.7236 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11981 34
zebrafish
(Danio rerio)
Actinopterygii aclya 34
  • 76.75 (n)
  • 87.17 (a)
aclya 35
  • 87 (a)
OneToMany
aclyb 35
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ATPCL 36
  • 67 (a)
ATPCL 34
  • 66.45 (n)
  • 70.55 (a)
ATPCL 35
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010156 34
  • 64.22 (n)
  • 70.54 (a)
worm
(Caenorhabditis elegans)
Secernentea B0365.1 36
  • 59 (a)
D1005.1 36
  • 58 (a)
acly-2 34
  • 58.32 (n)
  • 62.52 (a)
acly-2 35
  • 61 (a)
OneToMany
D1005.1 35
  • 60 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSC1 35
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACLB-1 34
  • 56.91 (n)
  • 53.58 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4574 34
rice
(Oryza sativa)
Liliopsida Os.8730 34
Os01g0300200 34
  • 55.13 (n)
  • 53.91 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.15086 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5723 34
bread mold
(Neurospora crassa)
Ascomycetes NCU06785 34
  • 64.01 (n)
  • 64.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1703.07 34
  • 60.72 (n)
  • 64.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToOne
Species where no ortholog for ACLY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACLY Gene

ENSEMBL:
Gene Tree for ACLY (if available)
TreeFam:
Gene Tree for ACLY (if available)

Paralogs for ACLY Gene

Paralogs for ACLY Gene

(1) SIMAP similar genes for ACLY Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ACLY: view

Variants for ACLY Gene

Sequence variations from dbSNP and Humsavar for ACLY Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2304497 - 41,909,521(+) TTGTC(C/G/T)TCAGG reference, synonymous-codon, missense
rs1058875 -- 41,912,479(-) GGGTC(A/G)ACCTC reference, missense
rs1802730 -- 41,883,150(-) CATCG(A/G)GACGT reference, missense
rs1802732 -- 41,868,752(-) GGAGC(C/G)CTCAA reference, synonymous-codon
rs1808787 -- 41,871,616(+) TCCCA(A/T)AGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACLY Gene

Variant ID Type Subtype PubMed ID
nsv1057008 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv475511 CNV novel sequence insertion 20440878
nsv833447 CNV loss 17160897

Variation tolerance for ACLY Gene

Residual Variation Intolerance Score: 1.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACLY Gene

Human Gene Mutation Database (HGMD)
ACLY
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACLY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACLY Gene

Disorders for ACLY Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACLY Gene - From: DISEASES

Disorder Aliases PubMed IDs
acrocallosal syndrome
  • joubert syndrome 12
- elite association - COSMIC cancer census association via MalaCards
Search ACLY in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACLY

Genetic Association Database (GAD)
ACLY
Human Genome Epidemiology (HuGE) Navigator
ACLY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACLY
genes like me logo Genes that share disorders with ACLY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACLY Gene

Publications for ACLY Gene

  1. Cloning and expression of a human ATP-citrate lyase cDNA. (PMID: 1371749) Elshourbagy N.A. … Gloger I.S. (Eur. J. Biochem. 1992) 2 3 4 22 65
  2. Localization of the gene for ATP citrate lyase (ACLY) distal to gastrin(GAS) and proximal to D17S856 on chromosome 17q12-q21. (PMID: 8088842) Couch F.J. … Weber B.L. (Genomics 1994) 2 3 22 65
  3. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. (PMID: 23932781) Lin R. … Lei Q.Y. (Mol. Cell 2013) 3 4 65
  4. ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. (PMID: 22102020) Sun T. … Fraser M.E. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011) 3 4 65
  5. Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas. (PMID: 19795461) Beckner M.E. … Pollack I.F. (Int. J. Cancer 2010) 3 22 65

Products for ACLY Gene

Sources for ACLY Gene

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