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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACLY Gene

protein-coding   GIFtS: 68
GCID: GC17M040023

ATP Citrate Lyase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATP Citrate Lyase1 2     EC 2.3.3.83 8
ATP Citrate Synthase1 2     ATPCL2
Citrate Cleavage Enzyme2 3     CLATP2
ACL2 3     ATP-Citrate Synthase2
ATP-Citrate (Pro-S-)-Lyase2 3     

External Ids:    HGNC: 1151   Entrez Gene: 472   Ensembl: ENSG000001314737   OMIM: 1087285   UniProtKB: P533963   

Export aliases for ACLY gene to outside databases

Previous GC identifers: GC17M039579 GC17M042174 GC17M039931 GC17M040396 GC17M037276 GC17M035785


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACLY Gene:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The
enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It
catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP
to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including
lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of
acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for ACLY Gene: 
ACLY (ATP citrate lyase) is a protein-coding gene. Diseases associated with ACLY include type 1 diabetes mellitus, and type 1 diabetes, and among its related super-pathways are Metabolic pathways and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include ATP citrate synthase activity and cofactor binding. An important paralog of this gene is SUCLG1.

UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396
Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many
tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis
of acetylcholine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACLY gene promoter:
         Max1   c-Myc   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACLY promoter sequence
   Search SABiosciences Chromatin IP Primers for ACLY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACLY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

ACLY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACLY gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040023:  view genomic region     (about GC identifiers)

Start:
40,023,161 bp from pter      End:
40,086,795 bp from pter
Size:
63,635 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 153,568-205,661     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396 (See protein sequence)
Recommended Name: ATP-citrate synthase  
Size: 1101 amino acids; 120839 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for ACLY:
3MWD (3D)        3MWE (3D)        3PFF (3D)    
Secondary accessions: B4DIM0 Q13037 Q9BRL0
Alternative splicing: 2 isoforms:  P53396-1   P53396-2   

Explore the universe of human proteins at neXtProt for ACLY: NX_P53396

Explore proteomics data for ACLY at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53396

  • 4/30 DME Specific Peptides for ACLY (P53396) (see all 30)
     KQGLYRH  WCIGTCA  FTYLEINP  TTDGVYEG 

    ACLY Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACLY Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001087.2  NP_942127.1  

    ENSEMBL proteins: 
     ENSP00000253792   ENSP00000466259   ENSP00000445349   ENSP00000377474   ENSP00000464717  
     ENSP00000468705   ENSP00000345398  
    Reactome Protein details: P53396
    Human Recombinant Protein Products for ACLY: 
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    Novus Biologicals ACLY Lysate
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    Sino Biological Cell Lysate for ACLY 
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    Cloud-Clone Corp. Proteins for ACLY 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    ACLY for ontologies           About GeneDecksing



    ACLY Antibody Products: 
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    Assay Products for ACLY: 
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    Cloud-Clone Corp. CLIAs for ACLY


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/13 InterPro protein domains (see all 13):
     IPR017866 Succ-CoA_synthase_bsu_CS
     IPR013650 ATP-grasp_succ-CoA_synth-type
     IPR016143 Citrate_synth-like_sm_a-sub
     IPR014608 ATP-citrate_synthase
     IPR005810 CoA_lig_alpha

    Graphical View of Domain Structure for InterPro Entry P53396

    ProtoNet protein and cluster: P53396

    2 Blocks protein domains:
    IPB003781 CoA Binding Domain
    IPB005809 Succinyl-CoA synthetase


    UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396
    Similarity: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family
    Similarity: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family


    ACLY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACLY_HUMAN, P53396
    Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many
    tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis
    of acetylcholine
    Catalytic activity: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA

         Genatlas biochemistry entry for ACLY:
    ATP-citrate lyase,catalyzing the synthesis of the cytosolic acetyl-CoA,used as a substrate for de novo
    biosynthesis of fatty acid and cholesterol

         Enzyme Number (IUBMB): EC 2.3.3.81 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0003878ATP citrate synthase activity TAS--
    GO:0004775succinate-CoA ligase (ADP-forming) activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    ACLY for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Acly):
     homeostasis/metabolism  mortality/aging 

    ACLY for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACLY 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACLY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACLY 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACLY 

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate ACLY (see all 14):
    hsa-miR-194* hsa-miR-22 hsa-miR-513a-5p hsa-miR-27a hsa-miR-3120-3p hsa-miR-374c hsa-miR-214 hsa-miR-567
    SwitchGear 3'UTR luciferase reporter plasmidACLY 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACLY


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACLY About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    2Fatty Acyl-CoA Biosynthesis
    Fatty Acyl-CoA Biosynthesis0.78
    Triglyceride Biosynthesis0.47
    3Regulation of Insulin Secretion
    Integration of energy metabolism0.74
    4Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    5Citric acid cycle (TCA cycle)
    Citrate cycle (TCA cycle)0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ACLY
        Regulation of lipid metabolism Insulin signaling-generic cascades


    1 Cell Signaling Technology (CST) Pathway for ACLY
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for ACLY
        Regulation of lipid metabolism Insulin signaling-generic cascades

    3 BioSystems Pathways for ACLY
        SREBP signalling
    Fatty Acid Biosynthesis
    acetyl-CoA biosynthesis III (from citrate)


    5/7        Reactome Pathways for ACLY (see all 7)
        ChREBP activates metabolic gene expression
    Metabolism
    Triglyceride Biosynthesis
    Integration of energy metabolism
    Fatty Acyl-CoA Biosynthesis


    2         Kegg Pathways  (Kegg details for ACLY):
        Citrate cycle (TCA cycle)
    Metabolic pathways


    ACLY for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACLY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/101 Interacting proteins for ACLY (P533962, 3 ENSP000002537924) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    PSMB1P206183, ENSP000002621934I2D: score=5 STRING: ENSP00000262193
    GSK3BP498413, ENSP000003248064I2D: score=4 STRING: ENSP00000324806
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006101citrate metabolic process TAS1371749
    GO:0006112energy reserve metabolic process TAS--
    GO:0006200ATP catabolic process TAS1371749
    GO:0008152metabolic process ----
    GO:0008610lipid biosynthetic process IDA--

    ACLY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACLY for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ACLY

    Browse Tocris compounds for ACLY

    7 HMDB Compounds for ACLY    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Citric acid2-Hydroxy-1,2,3-propanetricarboxylate (see all 20)77-92-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Oxalacetic acid2-Ketosuccinate (see all 20)328-42-7--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    10/28 Novoseek inferred chemical compound relationships for ACLY gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxycitrate 91 4 17476502 (1), 11319829 (1), 20372858 (1)
    (-)-hydroxycitrate 89.1 3 2176080 (1), 11101469 (1)
    acetyl-coa 84 26 14681844 (2), 8207683 (1), 7911658 (1), 11171136 (1) (see all 21)
    citrate 77.7 31 17928289 (2), 1765100 (2), 8207683 (1), 9820262 (1) (see all 21)
    oxaloacetate 69.9 7 7669753 (2), 11171137 (1), 1675605 (1), 18922930 (1)
    phosphohistidine 69.2 2 1371749 (1)
    pyruvate 62.2 14 8999918 (3), 17928289 (2), 11171136 (1), 7616129 (1) (see all 10)
    fatty acid 62.1 26 10410463 (3), 8999918 (3), 15869874 (1), 17476502 (1) (see all 15)
    6-phosphogluconate 60.9 2 14605988 (1), 8355562 (1)
    3-hydroxy-3-methylglutaryl-coa 57.8 7 8999918 (2), 18774944 (1), 19389950 (1)

    Search CenterWatch for drugs/clinical trials and news about ACLY

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACLY gene (2 alternative transcripts): 
    NM_001096.2  NM_198830.1  

    Unigene Cluster for ACLY:

    ATP citrate lyase
    Hs.387567  [show with all ESTs]
    Unigene Representative Sequence: NM_001096
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352035(uc002hyg.3 uc002hyi.3) ENST00000590151 ENST00000537919
    ENST00000393896 ENST00000588779 ENST00000590770 ENST00000588547 ENST00000590735
    ENST00000592970 ENST00000353196(uc002hyh.3 uc010wfx.2 uc010wfy.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate ACLY (see all 14):
    hsa-miR-194* hsa-miR-22 hsa-miR-513a-5p hsa-miR-27a hsa-miR-3120-3p hsa-miR-374c hsa-miR-214 hsa-miR-567
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    Additional mRNA sequence: 

    AB210035.1 AK058079.1 AK095084.1 AK295675.1 AK304802.1 AK312315.1 BC006195.2 U18197.1 
    X64330.1 

    22 DOTS entries:

    DT.40188466  DT.100820527  DT.100665906  DT.100820535  DT.91760382  DT.120917271  DT.100642777  DT.120917233 
    DT.95161296  DT.86850803  DT.95211622  DT.101977534  DT.120917265  DT.120917268  DT.91652223  DT.91760383 
    DT.91808785  DT.95161274  DT.95161295  DT.95359867  DT.97862140  DT.91697249 

    24/523 AceView cDNA sequences (see all 523):

    BM725670 BQ431667 BU508688 AI699623 R77758 AW878562 BQ681010 AV681852 
    AA853584 BQ050728 AI573048 BQ430304 BM467767 AI127728 CD610605 BQ423941 
    BC006195 BQ679687 NM_198830 AI417300 AI815071 AI885349 BG117315 BU192899 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACLY (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^
    SP1:                                                                                                                          -                             -   
    SP2:                                                                                                                          -                             -   
    SP3:                                                                                                                    -     -                             -   
    SP4:                          -     -     -                                                                                                                     
    SP5:                                                                                                                                                        -   

    ExUns: 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
    SP1:                                                              -                                             
    SP2:                                                              -                                             
    SP3:                                                              -                                             
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ACLY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACLY expression in normal human tissues (normalized intensities)      ACLY embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAACATTG
    ACLY Expression
    About this image


    ACLY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             brain/forebrain/telencephalon   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             autonomic/sympathetic/ganglion   
     
     Tooth
             visceral organ/oral region/upper jaw   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose   

    See ACLY Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACLY

    SOURCE GeneReport for Unigene cluster: Hs.387567
        SABiosciences Expression via Pathway-Focused PCR Arrays including ACLY: 
              Cancer PathwayFinder in human mouse rat
              Fatty Liver in human mouse rat
              Diabetes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACLY gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acly1 , 5 ATP citrate lyase1, 5 90.25(n)1
    98.09(a)1
      11 (63.47 cM)5
    1041121  NM_001199296.11  NP_001186225.11 
     1004763535 
    chicken
    (Gallus gallus)
    Aves ACLY1 ATP citrate lyase 80.23(n)
    93.19(a)
      395373  NM_001030540.1  NP_001025711.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACLY6
    Uncharacterized protein
    88(a)
    1 ↔ 1
    6(66483805-66551297)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.119812 Xenopus laevis transcribed sequence with strong similarity more 79.63(n)    BX846323.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aclya1 ATP citrate lyase a 76.75(n)
    87.17(a)
      436922  NM_001002649.1  NP_001002649.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ATPCL1 , 3 acetyl-CoA biosynthesis ATP-citrate
    (pro-S)-lyase3
    ATP citrate lyase1
    67(a)3
    66.39(n)1
    70.46(a)1
      367601  NM_166131.21  NP_725514.21 
    worm
    (Caenorhabditis elegans)
    Secernentea B0365.13
    acly-21
    ATP citrate lyase3
    Protein ACLY-21
    59(a)
    (best of 2)3
    58.63(n)1
    62.52(a)1
      V(13119107-13122639)3
    1797951  NM_073866.21  NP_506267.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LSC16
    Alpha subunit of succinyl-CoA ligase, which is a m...
    24(a)
    1 → many
    XV(593057-594046)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACLB-11 ATP-citrate lyase B-1 56.91(n)
    53.58(a)
      819845  NM_111541.3  NP_187317.1 
    rice
    (Oryza sativa)
    Liliopsida Os.87302 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.74(n)    AK062011.1 


    ENSEMBL Gene Tree for ACLY (if available)
    TreeFam Gene Tree for ACLY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACLY gene
    SUCLG12  
    1 SIMAP similar gene for ACLY using alignment to 4 protein entries:     ACLY_HUMAN (see all proteins):
    ACLY variant protein

    ACLY for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1092 SNPs in ACLY are shown (see all 1092)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105793541,2
    C--35801806(+) ttttt-/T/TTT 
            
    gagac
    2 -- int11NA 2
    rs753439711,2
    C--40023007(-) AACTCG/AGCCTC 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1899513961,2
    C--40023710(+) AAAAAA/GTGTTT 2 -- ut310--------
    rs1422505791,2
    --40023730(+) AAAAAC/GAAAGC 2 -- ut310--------
    rs733077291,2
    C,F--40023926(+) TCTTCG/AGTGCC 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs1158449621,2
    C--40024021(+) GGAAGA/CGATCT 2 -- ut311Minor allele frequency- C:0.01WA 118
    rs72172181,2
    C,A,H--40024023(+) AAGAGT/ATCTTG 2 -- ut31 ese3 trp312Minor allele frequency- A:0.08NA WA CSA EA 376
    rs2003153981,2
    --40024051(+) TAGGGC/TTCCTG 2 -- ut310--------
    rs1129351541,2
    C--40024159(+) TGTCCA/TAAAAT 2 -- spa10--------
    rs1997064311,2
    C--40024167(+) AATGAA/TGCAAA 2 -- int11Minor allele frequency- T:0.00EU 1323

    HapMap Linkage Disequilibrium report for ACLY (40023161 - 40086795 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACLY:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833447CNV Loss17160897
    nsv908238CNV Loss21882294


    Human Gene Mutation Database (HGMD): ACLY
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ACLY
    DNA2.0 Custom Variant and Variant Library Synthesis for ACLY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 108728    OMIM disorders: --

    15 diseases for ACLY:    About MalaCards
    type 1 diabetes mellitus    type 1 diabetes    diabetes mellitus    obesity
    glioblastoma    schizophrenia    hepatocellular carcinoma    ovarian cancer
    thyroiditis    lung cancer    prostate cancer    pancreatitis
    prostatitis    hepatitis    neuronitis


    ACLY for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ACLY gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 16226706 (1), 18922930 (1), 18796435 (1)
    cancer 0 3 16778563 (2), 20372858 (1)

    Genetic Association Database (GAD): ACLY
    Human Genome Epidemiology (HuGE) Navigator: ACLY (6 documents)

    Export disorders for ACLY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACLY gene, integrated from 9 sources (see all 152):
    (articles sorted by number of sources associating them with ACLY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a human ATP-citrate lyase cDNA. (PubMed id 1371749)1, 2, 3, 9 Elshourbagy N.A.... Gloger I.S. (1992)
    2. Localization of the gene for ATP citrate lyase (ACLY) distal to gastrin(GAS) and proximal to D17S856 on chromosome 17q12-q21. (PubMed id 8088842)1, 3, 9 Couch F.J....Weber B.L. (1994)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. Identification of the citrate-binding site of human A TP-citrate lyase using X-ray crystallography. (PubMed id 20558738)1, 2 Sun T....Fraser M.E. (2010)
    6. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    7. Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes. (PubMed id 18681781)1, 4 Srivastava V....Thelma B. (2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 47 HGNC: 115 AceView: ACLY Ensembl:ENSG00000131473 euGenes: HUgn47
    ECgene: ACLY Kegg: 47 H-InvDB: ACLY

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACLY Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACLY Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACLY gene:
    Search GeneIP for patents involving ACLY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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