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Aliases for ACLY Gene

Aliases for ACLY Gene

  • ATP Citrate Lyase 2 3
  • ATP-Citrate (Pro-S-)-Lyase 3 4
  • Citrate Cleavage Enzyme 3 4
  • ATP Citrate Synthase 2 3
  • EC 2.3.3.8 4 63
  • ACL 3 4
  • ATP-Citrate Synthase 3
  • ATPCL 3
  • CLATP 3

External Ids for ACLY Gene

Previous GeneCards Identifiers for ACLY Gene

  • GC17M039579
  • GC17M042174
  • GC17M039931
  • GC17M040396
  • GC17M037276
  • GC17M040023
  • GC17M035785

Summaries for ACLY Gene

Entrez Gene Summary for ACLY Gene

  • ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for ACLY Gene

ACLY (ATP Citrate Lyase) is a Protein Coding gene. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include cofactor binding and ATP citrate synthase activity. An important paralog of this gene is SUCLG1.

UniProtKB/Swiss-Prot for ACLY Gene

  • ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Tocris Summary for ACLY Gene

  • ATP citrate lyase (ATP citrate synthase, ACLY)�is a transferase that catalyzes the conversion of citrate and coenzyme A to acetyl-CoA. ACLY is the key regulator between the high rates of aerobic glycolysis and�de novo�lipid synthesis exhibited in many types of tumor cells.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACLY Gene

Genomics for ACLY Gene

Regulatory Elements for ACLY Gene

Genomic Location for ACLY Gene

Start:
41,866,908 bp from pter
End:
41,930,542 bp from pter
Size:
63,635 bases
Orientation:
Minus strand

Genomic View for ACLY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACLY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACLY Gene

Proteins for ACLY Gene

  • Protein details for ACLY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53396-ACLY_HUMAN
    Recommended name:
    ATP-citrate synthase
    Protein Accession:
    P53396
    Secondary Accessions:
    • B4DIM0
    • B4E3P0
    • Q13037
    • Q9BRL0

    Protein attributes for ACLY Gene

    Size:
    1101 amino acids
    Molecular mass:
    120839 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for ACLY Gene

    Alternative splice isoforms for ACLY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACLY Gene

Proteomics data for ACLY Gene at MOPED

Post-translational modifications for ACLY Gene

  • Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.
  • ISGylated.
  • Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
  • Ubiquitination at Lys4, Lys12, Lys17, Lys58, Lys64, Lys68, Lys82, Lys97, Lys148, Lys151, Lys230, Lys232, Lys259, Lys265, Lys272, Lys488, Lys498, Lys630, Lys650, Lys780, Lys836, Lys918, Lys944, Lys948, Lys991, Lys1077, Lys1080, and Lys471
  • Modification sites at PhosphoSitePlus

Other Protein References for ACLY Gene

Domains for ACLY Gene

Suggested Antigen Peptide Sequences for ACLY Gene

Graphical View of Domain Structure for InterPro Entry

P53396

UniProtKB/Swiss-Prot:

ACLY_HUMAN :
  • P53396
Domain:
  • Contains 1 ATP-grasp domain.
Family:
  • In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
  • In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
genes like me logo Genes that share domains with ACLY: view

No data available for Gene Families for ACLY Gene

Function for ACLY Gene

Molecular function for ACLY Gene

GENATLAS Biochemistry: ATP-citrate lyase,catalyzing the synthesis of the cytosolic acetyl-CoA,used as a substrate for de novo biosynthesis of fatty acid and cholesterol
UniProtKB/Swiss-Prot CatalyticActivity: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation results in a 6-fold increase in V(max) and the conversion of citrate dependence from sigmoidal to hyperbolic. Fructose 6-phosphate (F6P) is also a potent activator.
UniProtKB/Swiss-Prot Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Enzyme Numbers (IUBMB) for ACLY Gene

Gene Ontology (GO) - Molecular Function for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003878 ATP citrate synthase activity TAS 23932781
GO:0004775 succinate-CoA ligase (ADP-forming) activity IEA --
GO:0005515 protein binding IPI 23932781
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACLY: view

Phenotypes for ACLY Gene

genes like me logo Genes that share phenotypes with ACLY: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACLY Gene

Localization for ACLY Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACLY Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACLY Gene COMPARTMENTS Subcellular localization image for ACLY gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACLY: view

Pathways for ACLY Gene

genes like me logo Genes that share pathways with ACLY: view

Gene Ontology (GO) - Biological Process for ACLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006101 citrate metabolic process TAS 1371749
GO:0006112 energy reserve metabolic process TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0008152 metabolic process --
GO:0008610 lipid biosynthetic process IDA 23932781
genes like me logo Genes that share ontologies with ACLY: view

Compounds for ACLY Gene

(3) Tocris Compounds for ACLY Gene

Compound Action Cas Number
BMS 303141 ATP citrate lyase inhibitor; orally bioavailable [943962-47-8]
MEDICA 16 FFA1 (GPR40) agonist; also inhibits ATP citrate lyase [87272-20-6]
SB 204990 ATP-citrate lyase (ACL) inhibitor [154566-12-8]

(7) HMDB Compounds for ACLY Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Citric acid
  • 2-Hydroxy-1,2,3-propanetricarboxylate
77-92-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0

(28) Novoseek inferred chemical compound relationships for ACLY Gene

Compound -log(P) Hits PubMed IDs
hydroxycitrate 91 3
(-)-hydroxycitrate 89.1 2
acetyl-coa 84 22
citrate 77.7 23
oxaloacetate 69.9 5
genes like me logo Genes that share compounds with ACLY: view

Transcripts for ACLY Gene

Unigene Clusters for ACLY Gene

ATP citrate lyase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACLY Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - -
SP8:
SP9:

Relevant External Links for ACLY Gene

GeneLoc Exon Structure for
ACLY
ECgene alternative splicing isoforms for
ACLY

Expression for ACLY Gene

mRNA expression in normal human tissues for ACLY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACLY Gene

SOURCE GeneReport for Unigene cluster for ACLY Gene Hs.387567

genes like me logo Genes that share expressions with ACLY: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACLY Gene

Orthologs for ACLY Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACLY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACLY 35
  • 98.89 (n)
  • 99.22 (a)
ACLY 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACLY 35
  • 91.87 (n)
  • 98.53 (a)
ACLY 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACLY 35
  • 91.67 (n)
  • 98.18 (a)
ACLY 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acly 35
  • 90.25 (n)
  • 98.09 (a)
Acly 16
Acly 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACLY 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACLY 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acly 35
  • 90.25 (n)
  • 98.09 (a)
chicken
(Gallus gallus)
Aves ACL 36
  • 94 (a)
OneToOne
ACLY 35
  • 80.23 (n)
  • 93.19 (a)
lizard
(Anolis carolinensis)
Reptilia ACLY 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11981 35
tropical clawed frog
(Silurana tropicalis)
Amphibia acly 35
  • 78.86 (n)
  • 91.2 (a)
Str.7236 35
zebrafish
(Danio rerio)
Actinopterygii aclya 35
  • 76.75 (n)
  • 87.17 (a)
aclya 36
  • 87 (a)
OneToMany
aclyb 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010156 35
  • 64.22 (n)
  • 70.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta ATPCL 35
  • 66.45 (n)
  • 70.55 (a)
ATPCL 36
  • 69 (a)
OneToOne
ATPCL 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea acly-2 35
  • 58.32 (n)
  • 62.52 (a)
acly-2 36
  • 61 (a)
OneToMany
D1005.1 36
  • 60 (a)
OneToMany
D1005.1 37
  • 58 (a)
B0365.1 37
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSC1 36
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACLB-1 35
  • 56.91 (n)
  • 53.58 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4574 35
rice
(Oryza sativa)
Liliopsida Os.8730 35
Os01g0300200 35
  • 55.13 (n)
  • 53.91 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.15086 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06785 35
  • 64.01 (n)
  • 64.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1703.07 35
  • 60.72 (n)
  • 64.98 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5723 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for ACLY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACLY Gene

ENSEMBL:
Gene Tree for ACLY (if available)
TreeFam:
Gene Tree for ACLY (if available)

Paralogs for ACLY Gene

Paralogs for ACLY Gene

Selected SIMAP similar genes for ACLY Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ACLY: view

Variants for ACLY Gene

Sequence variations from dbSNP and Humsavar for ACLY Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs878892 -- 41,913,489(-) CAAAC(G/T)GGTGT intron-variant
rs893009 -- 41,908,198(+) AGACT(C/T)TGCCC intron-variant
rs1058875 -- 41,912,479(-) GGGTC(A/G)ACCTC reference, missense
rs1136262 -- 41,910,235(-) CTTCG(C/T)CCCCC missense, reference
rs1136263 -- 41,898,658(-) AACTT(C/T)CTCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ACLY Gene

Variant ID Type Subtype PubMed ID
nsv833447 CNV Loss 17160897
nsv908238 CNV Loss 21882294

Relevant External Links for ACLY Gene

HapMap Linkage Disequilibrium report
ACLY
Human Gene Mutation Database (HGMD)
ACLY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACLY Gene

Disorders for ACLY Gene

(2) Novoseek inferred disease relationships for ACLY Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3
cancer 0 3

Relevant External Links for ACLY

Genetic Association Database (GAD)
ACLY
Human Genome Epidemiology (HuGE) Navigator
ACLY
genes like me logo Genes that share disorders with ACLY: view

No data available for UniProtKB/Swiss-Prot for ACLY Gene

Publications for ACLY Gene

  1. Cloning and expression of a human ATP-citrate lyase cDNA. (PMID: 1371749) Elshourbagy N.A. … Gloger I.S. (Eur. J. Biochem. 1992) 2 3 4 23
  2. Localization of the gene for ATP citrate lyase (ACLY) distal to gastrin(GAS) and proximal to D17S856 on chromosome 17q12-q21. (PMID: 8088842) Couch F.J. … Weber B.L. (Genomics 1994) 2 3 23
  3. Sequence of sites on ATP-citrate lyase and phosphatase inhibitor 2 phosphorylated by multifunctional protein kinase (a glycogen synthase kinase 3 like kinase). (PMID: 2176822) Ramakrishna S. … Benjamin W.B. (Biochemistry 1990) 3 23
  4. The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. (PMID: 14681844) Michno A. … Szutowicz A. (Metab. Clin. Exp. 2004) 3 23
  5. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer. (PMID: 18922930) Migita T. … Ishikawa Y. (Cancer Res. 2008) 3 23

Products for ACLY Gene

Sources for ACLY Gene

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