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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACLY Gene

protein-coding   GIFtS: 64
GCID: GC17M040023

ATP citrate lyase
 Explore 15 diseases affiliated with
ACLY via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ACLY    

Aliases
for ACLY gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATP Citrate Lyase1 2     ATP-Citrate (Pro-S-)-Lyase2 3
ACL1 2 3     EC 2.3.3.83 8
ATPCL1 2     ATP Citrate Synthase2
CLATP1 2     ATP-Citrate Synthase2
Citrate Cleavage Enzyme2 3     

External Ids:    HGNC: 1151   Entrez Gene: 472   Ensembl: ENSG000001314737   OMIM: 1087285   UniProtKB: P533963   

Export aliases for ACLY gene to outside databases

Previous GC identifers: GC17M039579 GC17M042174 GC17M039931 GC17M040396 GC17M037276 GC17M035785


Summaries
for ACLY gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ACLY:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The
enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes
the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and
phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and
cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two
transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396
Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many
tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of
acetylcholine




Genomic Views
for ACLY gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACLY gene promoter:
         Max1   c-Myc   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACLY promoter sequence
   Search SABiosciences Chromatin IP Primers for ACLY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACLY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

ACLY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACLY gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040023:  view genomic region     (about GC identifiers)

Start:
 40,023,161 bp from pter      End:
 40,086,795 bp from pter
Size:
 63,635 bases      Orientation:
 minus strand

Proteins
for ACLY gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396 (See protein sequence)
Recommended Name: ATP-citrate synthase  
Size: 1101 amino acids; 120839 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for ACLY:
3MWD (3D)        3MWE (3D)        3PFF (3D)    
Secondary accessions: B4DIM0 Q13037 Q9BRL0
Alternative splicing: 2 isoforms:  P53396-1   P53396-2   

Explore the universe of human proteins at neXtProt for ACLY: NX_P53396

Post-translational modifications:

  • ISGylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P53396

    • 4/30 DME Specific Peptides for ACLY (P53396) (see all 30)
     KQGLYRH  WCIGTCA  FTYLEINP  TTDGVYEG 

    ACLY Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001087.2  NP_942127.1  

    ENSEMBL proteins: 
     ENSP00000253792   ENSP00000466259   ENSP00000445349   ENSP00000377474   ENSP00000464717  
     ENSP00000468705   ENSP00000345398  
    Reactome Protein details: P53396
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ACLY
    OriGene Protein Over-expression Lysate: ACLY
    OriGene Custom Protein Services for ACLY 
    GenScript Custom Purified and Recombinant Proteins Services for ACLY
    Novus Biologicals ACLY Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ACLY

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--


    ACLY for ontologies           About GeneDecksing



    ACLY Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cell Signaling Technology (CST) Antibodies for ACLY 
    OriGene Antibodies (see all 4): ACLY
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    GenScript Custom Superior Antibodies Services for ACLY
    Novus Biologicals ACLY Antibodies
    Abcam antibodies for ACLY 
    Uscn Antibodies for ACLY
    Search ThermoFisher Antibodies for ACLY

    Assay Products for ACLY: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACLY
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ACLY

    Protein Domains /
    Families
    for ACLY gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ACLY for domains           About GeneDecksing

    5/13 InterPro domains/families (see all 13):
     IPR017866 Succ-CoA_synthase_bsu_CS
     IPR013650 ATP-grasp_succ-CoA_synth-type
     IPR016143 Citrate_synth-like_sm_a-sub
     IPR014608 ATP-citrate_synthase
     IPR005810 CoA_lig_alpha

    Graphical View of Domain Structure for InterPro Entry P53396

    ProtoNet protein and cluster: P53396

    2 Blocks protein families:
    IPB003781 CoA Binding Domain
    IPB005809 Succinyl-CoA synthetase


    UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396
    Similarity: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family
    Similarity: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family


    Function
    for ACLY gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACLY_HUMAN, P53396
    Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many
    tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of
    acetylcholine
    Catalytic activity: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA

         Genatlas biochemistry entry for ACLY:
    ATP-citrate lyase,catalyzing the synthesis of the cytosolic acetyl-CoA,used as a substrate for de novo biosynthesis of
    fatty acid and cholesterol

    Enzyme Number (IUBMB): EC 2.3.3.81 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): ACLY
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACLY
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate ACLY (see all 14):
    hsa-miR-194* hsa-miR-22 hsa-miR-513a-5p hsa-miR-27a hsa-miR-3120-3p hsa-miR-374c hsa-miR-214 hsa-miR-567
    SwitchGear 3'UTR luciferase reporter plasmid: ACLY 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACLY (see all 7)
    OriGene shRNA RFP: ACLY
    OriGene siRNA: ACLY
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACLY

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ACLY

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACLY (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACLY (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ACLY (NM_198830)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACLY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACLY 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ACLY
    Search LifeMap BioReagents cell lines for ACLY

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACLY

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003878ATP citrate synthase activity TAS--
    GO:0004775succinate-CoA ligase (ADP-forming) activity IEA--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--


    ACLY for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Acly):
     homeostasis/metabolism  mortality/aging 

    ACLY for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ACLY gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    2Saturated fatty acid biosynthesis
    		ChREBP activates metabolic gene expression0.38
    		acetyl-CoA biosynthesis III (from citrate)0.00
    		Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX0.00
    3Fatty Acyl-CoA Biosynthesis
    		Fatty Acyl-CoA Biosynthesis1.00
    		Triglyceride Biosynthesis0.47
    4Development_CNTF receptor signaling
    		Regulation of lipid metabolism_Insulin signaling-generic cascades0.35
    		Regulation of lipid metabolism Insulin signaling:generic cascades0.35
    5Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ACLY
        Regulation of lipid metabolism Insulin signaling-generic cascades


    1 Cell Signaling Technology (CST) Pathway for ACLY
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for ACLY
        Regulation of lipid metabolism Insulin signaling-generic cascades

    3 BioSystems Pathways for ACLY 
        SREBP signalling
    Fatty Acid Biosynthesis
    acetyl-CoA biosynthesis III (from citrate)

    5/8        Reactome Pathways for ACLY (see all 8)
        Metabolism
    Triglyceride Biosynthesis
    Integration of energy metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    ChREBP activates metabolic gene expression


    2         Kegg Pathways  (Kegg details for ACLY):
        Citrate cycle (TCA cycle)
    Metabolic pathways


    ACLY for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACLY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for ACLY (P533962, 3 ENSP000002537924) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    PSMB1P206183, ENSP000002621934I2D: score=5 STRING: ENSP00000262193
    GSK3BP498413, ENSP000003248064I2D: score=4 STRING: ENSP00000324806
    NME1-NME2P223923I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006101citrate metabolic process TAS1371749
    GO:0006112energy reserve metabolic process TAS--
    GO:0006200ATP catabolic process TAS1371749
    GO:0015936coenzyme A metabolic process TAS1371749
    GO:0019432triglyceride biosynthetic process TAS--


    ACLY for ontologies           About GeneDecksing



    Drugs & Compounds
    for ACLY gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACLY for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ACLY

    Browse Tocris compounds for ACLY

    7 HMDB Compounds for ACLY    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Citric acid2-Hydroxy-1,2,3-propanetricarboxylate (see all 20)77-92-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Oxalacetic acid2-Ketosuccinate (see all 20)328-42-7--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    10/28 Novoseek chemical compound relationships for ACLY gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxycitrate 91 4 17476502 (1), 11319829 (1), 20372858 (1)
    (-)-hydroxycitrate 89.1 3 2176080 (1), 11101469 (1)
    acetyl-coa 84 26 14681844 (2), 8207683 (1), 7911658 (1), 11171136 (1) (see all 21)
    citrate 77.7 31 17928289 (2), 1765100 (2), 8207683 (1), 9820262 (1) (see all 21)
    oxaloacetate 69.9 7 7669753 (2), 11171137 (1), 1675605 (1), 18922930 (1)
    phosphohistidine 69.2 2 1371749 (1)
    pyruvate 62.2 14 8999918 (3), 17928289 (2), 11171136 (1), 7616129 (1) (see all 10)
    fatty acid 62.1 26 10410463 (3), 8999918 (3), 15869874 (1), 17476502 (1) (see all 15)
    6-phosphogluconate 60.9 2 14605988 (1), 8355562 (1)
    3-hydroxy-3-methylglutaryl-coa 57.8 7 8999918 (2), 18774944 (1), 19389950 (1)

    Search CenterWatch for drugs/clinical trials and news about ACLY 

    Transcripts
    for ACLY gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ACLY gene (2 alternative transcripts): 
    NM_001096.2  NM_198830.1  

    Unigene Cluster for ACLY:

    ATP citrate lyase
    Hs.387567  [show with all ESTs]
    Unigene Representative Sequence: NM_001096
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352035(uc002hyg.3 uc002hyi.3) ENST00000590151 ENST00000537919
    ENST00000393896 ENST00000588779 ENST00000590770 ENST00000588547 ENST00000590735
    ENST00000592970 ENST00000353196(uc002hyh.3 uc010wfx.2 uc010wfy.2)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ACLY
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACLY
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate ACLY (see all 14):
    hsa-miR-194* hsa-miR-22 hsa-miR-513a-5p hsa-miR-27a hsa-miR-3120-3p hsa-miR-374c hsa-miR-214 hsa-miR-567
    SwitchGear 3'UTR luciferase reporter plasmid: ACLY 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACLY (see all 7)
    OriGene shRNA RFP: ACLY
    OriGene siRNA: ACLY
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACLY
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACLY (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 2): ACLY (NM_198830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACLY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACLY 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACLY
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACLY
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACLY

    Additional cDNA sequence: 

    AB210035.1 AK058079.1 AK095084.1 AK295675.1 AK304802.1 AK312315.1 BC006195.2 U18197.1 
    X64330.1 

    22 DOTS entries:

    DT.40188466  DT.100820527  DT.100665906  DT.100820535  DT.91760382  DT.120917271  DT.100642777  DT.120917233 
    DT.95161296  DT.86850803  DT.95211622  DT.101977534  DT.120917265  DT.120917268  DT.91652223  DT.91760383 
    DT.91808785  DT.95161274  DT.95161295  DT.95359867  DT.97862140  DT.91697249 

    24/523 AceView cDNA sequences (see all 523):

    BP364222 AI697052 AI632007 AI573048 AA363991 AW872778 BM549171 AI906366 
    BP356928 BQ774639 AI364214 NM_198830 BQ024361 NM_001096 BQ431218 BQ059802 
    BQ430304 AI885349 BQ678057 BU160670 BP363686 AU130024 AW672850 AI497943 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACLY (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^
    SP1:                                                                                                                          -                             -   
    SP2:                                                                                                                          -                             -   
    SP3:                                                                                                                    -     -                             -   
    SP4:                          -     -     -                                                                                                                     
    SP5:                                                                                                                                                        -   

    ExUns: 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
    SP1:                                                              -                                             
    SP2:                                                              -                                             
    SP3:                                                              -                                             
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ACLY

    Expression
    for ACLY gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACLY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGAACATTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ACLY expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    HeartAtrioventricular CanalHeart
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ACLY Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACLY

    SOURCE GeneReport for Unigene cluster: Hs.387567
        SABiosciences Expression via Pathway-Focused PCR Arrays including ACLY: 
              Cancer PathwayFinder in human mouse rat
              Fatty Liver in human mouse rat
              Diabetes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACLY
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACLY

    Orthologs
    for ACLY gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACLY gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Acly1 , 5 ATP citrate lyase1, 5 90.25(n)1
    98.09(a)1    		   11 (63.47 cM)5
    1041121  NM_001199296.11  NP_001186225.11 
     1004763535 
    chicken
    (Gallus gallus)    		 Aves ACLY1 ATP citrate lyase 80.23(n)
    93.19(a)    		   395373  NM_001030540.1  NP_001025711.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ACLY6
    		 --
    		 92(a)
    		 1 ↔ 1
    		 6(66511453-66551297)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.119812 Xenopus laevis transcribed sequence with strong similarity more 79.63(n)    BX846323.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii aclya1 ATP citrate lyase a 76.75(n)
    87.17(a)    		   436922  NM_001002649.1  NP_001002649.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ATPCL1 , 3 acetyl-CoA biosynthesis ATP-citrate
    (pro-S)-lyase3
    ATP citrate lyase1    		 67(a)3
    66.39(n)1
    70.46(a)1    		   367601  NM_166131.21  NP_725514.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0365.13
    acly-21    		 ATP citrate lyase3
    Protein ACLY-21    		 59(a)
    (best of 2)3
    58.63(n)1
    62.52(a)1    		   V(13119107-13122639)3
    1797951  NM_073866.21  NP_506267.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ACLB-11 ATP-citrate lyase B-1 56.91(n)
    53.58(a)    		   819845  NM_111541.3  NP_187317.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.87302 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.74(n)    AK062011.1 


    ENSEMBL Gene Tree for ACLY (if available)
    TreeFam Gene Tree for ACLY (if available) 

    Paralogs
    for ACLY gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACLY gene
    SUCLG12  
    1 SIMAP similar gene for ACLY using alignment to 4 protein entries:     ACLY_HUMAN (see all proteins):
    ACLY variant protein

    ACLY for paralogs           About GeneDecksing



    Genomic Variants
    for ACLY gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/850 NCBI SNPs in ACLY are shown (see all 850)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1115970571,2
    		C--35784891(+) AGCAGG/AACCTT 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1113260581,2
    		C,--35784945(+) CTCCTG/TTAGTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1126853701,2
    		--35785083(+) TACAGC/TTACAA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs10589281,2
    		F--35785219(-) AATCCA/CCAAAG 1 -- us2k1 ese31Minor allele frequency- C:0.03MN 184
    rs712287891,2
    		C--35785580(-) CTCTCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs99444221,2
    		C,F--40022724(+) GCCTCG/AGCCTC 2 -- ds50014Minor allele frequency- A:0.29NA WA CSA 7
    rs1868114711,2
    		--40022761(+) GCCACC/TACGCC 2 -- ds50010--------
    rs93033191,2
    		C,F,A,H,--40022809(+) AAACTG/ATTAGT 2 -- ds500122Minor allele frequency- A:0.25NS EA WA NA CSA 2346
    rs1997639851,2
    		--40022908(+) CCAGA-/CCAGAGC 2 -- ds50010--------
    rs93033201,2
    		C,--40022909(+) CCAGAC/AGAGCC 2 -- ds50014Minor allele frequency- A:0.08NA WA EA 360

    HapMap Linkage Disequilibrium report for ACLY (40023161 - 40086795 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACLY: --
    Human Gene Mutation Database (HGMD): ACLY

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACLY
    DNA2.0 Custom Variant and Variant Library Synthesis for ACLY

    Disorders / Diseases
    for ACLY gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ACLY for disorders           About GeneDecksing

    OMIM gene information: 108728    OMIM disorders: --

    15 diseases for ACLY:    About MalaCards
    type 1 diabetes mellitus    diabetes mellitus    hepatocellular carcinoma    lung cancer
    prostate cancer    glioblastoma    obesity    cholesterol
    prostatitis    schizophrenia    thyroiditis    carcinoma
    pancreatitis    hepatitis    neuronitis

    2 Novoseek disease relationships for ACLY gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 16226706 (1), 18922930 (1), 18796435 (1)
    cancer 0 3 16778563 (2), 20372858 (1)

    Human Genome Epidemiology (HuGE) Navigator: ACLY (6 documents)

    Export disorders for ACLY gene to outside databases

    Publications
    for ACLY gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACLY gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with ACLY)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a human ATP-citrate lyase cDNA. (PubMed id 1371749)1, 2, 3, 9 Elshourbagy N.A.... Gloger I.S. (1992)
    2. Localization of the gene for ATP citrate lyase (ACLY) distal to gastrin(GAS) and proximal to D17S856 on chromosome 17q12-q21. (PubMed id 8088842)1, 3, 9 Couch F.J....Weber B.L. (1994)
    3. Identification of the citrate-binding site of human A TP-citrate lyase using X-ray crystallography. (PubMed id 20558738)1, 2 Sun T....Fraser M.E. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Variant cDNA sequences of human ATP:citrate lyase: cloning, expression, and purification from baculovirus-infected insect cells. (PubMed id 9116495)1, 2 Lord K.A....Ciccarelli R.B. (1997)
    9. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer. (PubMed id 18922930)1, 9 Migita T....Ishikawa Y. (2008)
    10. Sequence of sites on ATP-citrate lyase and phosphatase inhibitor 2 phosphorylated by multifunctional protein kinase (a glycogen synthase kinase 3 like kinase). (PubMed id 2176822)1, 9 Ramakrishna S....Benjamin W.B. (1990)

    External Searches for ACLY gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ACLY gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 47 HGNC: 115 AceView: ACLY Ensembl:ENSG00000131473 euGenes: HUgn47
    ECgene: ACLY Kegg: 47 H-InvDB: ACLY

    Other Databases showing ACLY gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ACLY gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACLY Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ACLY gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ACLY gene:
    Search GeneIP for patents involving ACLY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ACLY gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    Advanced Cell Diagnostics
    About This Section

     
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