Aliases for ACKR4 Gene
Aliases for ACKR4 Gene
External Ids for ACKR4 Gene
- HGNC: 1611
- Entrez Gene: 51554
- Ensembl: ENSG00000129048
- OMIM: 606065
- UniProtKB: Q9NPB9
Previous HGNC Symbols for ACKR4 Gene
- CCRL1
Previous GeneCards Identifiers for ACKR4 Gene
- GC03P132317
Summaries for ACKR4 Gene
-
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
GeneCards Summary for ACKR4 Gene
ACKR4 (Atypical Chemokine Receptor 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR7.
UniProtKB/Swiss-Prot for ACKR4 Gene
-
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACKR4 Gene
Genomics for ACKR4 Gene
Regulatory Elements for ACKR4 Gene
Enhancers for ACKR4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03F132540 | 1.3 | FANTOM5 Ensembl ENCODE | 10.8 | -54.5 | -54525 | 3.5 | SAP130 JUN CEBPG ZBTB40 RARA FOSL2 FOS NR2F6 HOMEZ TCF7L2 | UBA5 ACKR4 NPHP3 DNAJC13 |
| GH03F132554 | 0.8 | Ensembl ENCODE | 11.5 | -42.7 | -42684 | 0.3 | CTBP1 PKNOX1 GATA3 L3MBTL2 DPF2 FOS | ACKR4 UBA5 ACAD11 DNAJC13 |
| GH03F132535 | 0.7 | ENCODE | 10.6 | -61.0 | -61023 | 1.3 | CTCF CREB3L1 SIN3A DMAP1 RAD21 ZFHX2 ZNF143 SMC3 ZSCAN29 FOS | UBA5 ACAD11 ACKR4 DNAJC13 |
| GH03F132555 | 0.5 | ENCODE | 11.7 | -40.6 | -40591 | 2.0 | PBX2 IKZF1 ZNF24 MNT | ACKR4 UBA5 ACAD11 DNAJC13 |
| GH03F132431 | 1 | Ensembl ENCODE | 5.7 | -164.5 | -164507 | 1.8 | ATF1 BHLHE40 JUN SIN3A DPF2 ARID1B GATA3 JUND ATF3 SMARCA4 | ACKR4 DNAJC13 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ACKR4 on UCSC Golden Path with GeneCards custom track
Promoters for ACKR4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|---|---|---|
| ENSR00001852424 | 263 | 600 |
Regulatory Element Products
Genomic Location for ACKR4 Gene
- Chromosome:
- 3
- Start:
- 132,597,237 bp from pter
- End:
- 132,618,967 bp from pter
- Size:
- 21,731 bases
- Orientation:
- Plus strand
Genomic View for ACKR4 Gene
Genes around ACKR4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q22.1 by Ensembl
- 3q22.1 by Entrez Gene
- 3q22.1 by HGNC
ACKR4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACKR4 Gene
Proteins for ACKR4 Gene
-
Protein details for ACKR4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NPB9-ACKR4_HUMAN
- Recommended name:
- Atypical chemokine receptor 4
- Protein Accession:
- Q9NPB9
- B2R9U7
Protein attributes for ACKR4 Gene
- Size:
- 350 amino acids
- Molecular mass:
- 39914 Da
- Quaternary structure:
-
- Forms heteromers with CXCR3. Interacts with ARRB1 and ARRB2.
Post-translational modifications for ACKR4 Gene
- The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
- Glycosylation at Asn 6 and Asn 19
- Modification sites at PhosphoSitePlus
Other Protein References for ACKR4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ACKR4
- R&D Systems Antibodies for ACKR4 (CCR11)
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- Invitrogen Antibodies for ACKR4
- antibodies-online Antibodies for ACKR4: See all 40
- GeneTex ACKR4 antibody for ACKR4
-
St John's Laboratory Antibodies for ACKR4
Protein Products
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Assay Products
- antibodies-online Kits for ACKR4: See all 10
No data available for DME Specific Peptides for ACKR4 Gene
Domains & Families for ACKR4 Gene
Gene Families for ACKR4 Gene
- HGNC:
- IUPHAR :
Protein Domains for ACKR4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACKR4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NPB9UniProtKB/Swiss-Prot:
ACKR4_HUMAN :- Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
- Family:
-
- Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
Function for ACKR4 Gene
Molecular function for ACKR4 Gene
- UniProtKB/Swiss-Prot Function:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004950 | chemokine receptor activity | IDA | 23341447 |
| GO:0005044 | scavenger receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 23341447 |
| GO:0019956 | chemokine binding | IEA | -- |
Phenotypes for ACKR4 Gene
- MGI mutant phenotypes for ACKR4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ACKR4:
Animal Model Products
-
Taconic Biosciences Mouse Models for ACKR4
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ACKR4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACKR4 gene
- Search ViGene Biosciences for ACKR4
CRISPR Products
-
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miRNA Products
- Search ViGene Biosciences for ACKR4
Inhibitory RNA Products
- Origene shRNA, RNAi, mouse_rna, and siRNA products in human, mouse, rat for ACKR4
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-
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Clone Products
- Sino Biological Human cDNA Clone for ACKR4
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- VectorBuilder custom plasmid, inducible vectors for ACKR4
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ACKR4 (CCR11)
Cell Line Products
-
Horizon Cell Lines for ACKR4
-
ViGene Biosciences adenoviral particle packaged cDNA for ACKR4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ACKR4 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ACKR4 Gene
Localization for ACKR4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACKR4 Gene
- Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 10767544 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for ACKR4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions | ||
| 3 | Signaling by GPCR | ||
Pathways by source for ACKR4 Gene
1 BioSystems pathway for ACKR4 Gene
6 Reactome pathways for ACKR4 Gene
1 R&D Systems pathway for ACKR4 Gene
Interacting Proteins for ACKR4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006898 | receptor-mediated endocytosis | IEA | -- |
| GO:0006935 | chemotaxis | IEA,TAS | -- |
| GO:0006955 | immune response | TAS | 10706668 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA,TAS | -- |
No data available for SIGNOR curated interactions for ACKR4 Gene
Transcripts for ACKR4 Gene
mRNA/cDNA for ACKR4 Gene
- (2) REFSEQ mRNAs :
- (25) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ACKR4
- GenScript: Design CRISPR guide RNA sequences for ACKR4
miRNA Products
- Search ViGene Biosciences for ACKR4
Inhibitory RNA Products
- Origene shRNA, RNAi, mouse_rna, and siRNA products in human, mouse, rat for ACKR4
- Browse OriGene Inhibitory RNA Products For ACKR4
-
ViGene Biosciences ready-to-package AAV shRNAs for ACKR4 gene
Clone Products
- Sino Biological Human cDNA Clone for ACKR4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACKR4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACKR4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ACKR4 (CCR11)
Flow Cytometry Products
Expression for ACKR4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Endothelium (Cardiovascular System)
NURSA nuclear receptor signaling pathways regulating expression of ACKR4 Gene:
ACKR4mRNA Expression by UniProt/SwissProt for ACKR4 Gene:
Q9NPB9-ACKR4_HUMAN
Tissue specificity:
Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
Primer Products
-
OriGene qPCR primer pairs for ACKR4
-
OriGene qPCR primer pairs and template standards for ACKR4
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ACKR4 Gene
Orthologs for ACKR4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCRL1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ACKR4 34 |
|
||
| CCRL1 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ACKR4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ackr4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ackr4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ACKR4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACKR4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCRL1 34 |
|
||
| ACKR4 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | ACKR4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccrl1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-106h4.12 34 |
|
||
| ackr4a 35 |
|
OneToMany | |||
| ackr4b 35 |
|
OneToMany |
- Species where no ortholog for ACKR4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ACKR4 Gene
Paralogs for ACKR4 Gene
(31) SIMAP similar genes for ACKR4 Gene using alignment to 2 proteins:
Variants for ACKR4 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10935020 | -- | 132,595,977(+) | catgc(A/T)tatgt | intron-variant, upstream-variant-2KB | |
| rs111404721 | -- | 132,602,975(+) | TTTTT(G/T)TATTT | intron-variant, downstream-variant-500B | |
| rs111608953 | -- | 132,595,518(+) | GACAA(C/T)TTACA | intron-variant, upstream-variant-2KB | |
| rs111662931 | -- | 132,598,434(+) | CTACT(C/T)TGTGC | intron-variant, upstream-variant-2KB | |
| rs112742091 | -- | 132,596,280(+) | GGGTA(C/G)AGGGT | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.30;
25.84% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ACKR4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACKR4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACKR4 Gene
Disorders for ACKR4 Gene
Relevant External Links for ACKR4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ACKR4
No disorders were found for ACKR4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACKR4 Gene
Publications for ACKR4 Gene
- Characterization of mouse CCX-CKR, a receptor for the lymphocyte- attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. (PMID: 11981810) Townson J.R. … Nibbs R.J. (Eur. J. Immunol. 2002) 3 4 22 64
- Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart. (PMID: 10767544) Khoja H. … Shyamala V. (Gene 2000) 2 3 4 64
- Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. (PMID: 10706668) Gosling J. … Schall T.J. (J. Immunol. 2000) 3 4 22 64
- Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. (PMID: 23121557) Vinet J. … Boddeke H.W. (Br. J. Pharmacol. 2013) 3 4 64
- I^-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. (PMID: 23341447) Watts A.O. … Vischer H.F. (J. Biol. Chem. 2013) 3 4 64
Products for ACKR4 Gene
- R&D Systems Antibodies for ACKR4 (CCR11)
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- Novus Biologicals Antibodies for ACKR4
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- Taconic Biosciences Mouse Models for ACKR4
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- Humanized Mice
- antibodies-online Antibodies for ACKR4: See all 40
- antibodies-online Kits for ACKR4: See all 10
- Search antibodies-online for proteins
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- GeneTex ACKR4 antibody for ACKR4
- Search GeneTex for Proteins for ACKR4
- ViGene Biosciences adenoviral particle packaged cDNA for ACKR4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ACKR4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ACKR4 gene
- Search ViGene Biosciences for ACKR4
- Horizon Cell Lines for ACKR4
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACKR4
- VectorBuilder custom plasmid, inducible vectors for ACKR4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACKR4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ACKR4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
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