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Aliases for ACKR2 Gene

Aliases for ACKR2 Gene

  • Atypical Chemokine Receptor 2 2 3 5
  • Chemokine-Binding Protein D6 3 4
  • Chemokine Binding Protein 2 2 3
  • Chemokine-Binding Protein 2 3 4
  • Chemokine Receptor CCR-10 3 4
  • C-C Chemokine Receptor D6 3 4
  • Chemokine Receptor CCR-9 3 4
  • CMKBR9 3 4
  • CCBP2 3 4
  • CCR10 3 4
  • D6 3 4
  • CC-Chemokine-Binding Receptor JAB61 3
  • Chemokine (C-C Motif) Receptor 9 3
  • Chemokine (C-C) Receptor 9 3
  • Chemokine Receptor D6 3
  • CCR9 3
  • HD6 3

External Ids for ACKR2 Gene

Previous HGNC Symbols for ACKR2 Gene

  • CMKBR9
  • CCBP2

Previous GeneCards Identifiers for ACKR2 Gene

  • GC03P042846

Summaries for ACKR2 Gene

Entrez Gene Summary for ACKR2 Gene

  • This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACKR2 Gene

ACKR2 (Atypical Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with ACKR2 include cd45 deficiency. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for ACKR2 Gene

  • Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.

Gene Wiki entry for ACKR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACKR2 Gene

Genomics for ACKR2 Gene

Genomic Location for ACKR2 Gene

Chromosome:
3
Start:
42,804,752 bp from pter
End:
42,887,974 bp from pter
Size:
83,223 bases
Orientation:
Plus strand

Genomic View for ACKR2 Gene

Genes around ACKR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACKR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACKR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACKR2 Gene

No data available for Regulatory Elements for ACKR2 Gene

Proteins for ACKR2 Gene

  • Protein details for ACKR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00590-ACKR2_HUMAN
    Recommended name:
    Atypical chemokine receptor 2
    Protein Accession:
    O00590
    Secondary Accessions:
    • B2R8Y8
    • O00537
    • Q53YA1
    • Q86UN9
    • Q96A02

    Protein attributes for ACKR2 Gene

    Size:
    384 amino acids
    Molecular mass:
    43443 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACKR2 Gene

Proteomics data for ACKR2 Gene at MOPED

Post-translational modifications for ACKR2 Gene

  • Phosphorylated on serine residues in the C-terminal cytoplasmic tail.
  • Glycosylation at Asn 19
  • Modification sites at PhosphoSitePlus

Other Protein References for ACKR2 Gene

No data available for DME Specific Peptides for ACKR2 Gene

Domains & Families for ACKR2 Gene

Gene Families for ACKR2 Gene

Protein Domains for ACKR2 Gene

Suggested Antigen Peptide Sequences for ACKR2 Gene

Graphical View of Domain Structure for InterPro Entry

O00590

UniProtKB/Swiss-Prot:

ACKR2_HUMAN :
  • The C-terminal cytoplasmic tail controls its phosphorylation, stability, intracellular trafficking itinerary, and chemokine scavenging properties.
  • Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
Domain:
  • The C-terminal cytoplasmic tail controls its phosphorylation, stability, intracellular trafficking itinerary, and chemokine scavenging properties.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
genes like me logo Genes that share domains with ACKR2: view

Function for ACKR2 Gene

Molecular function for ACKR2 Gene

UniProtKB/Swiss-Prot Function:
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
UniProtKB/Swiss-Prot Induction:
By interleukin-6 and interferon-gamma.

Gene Ontology (GO) - Molecular Function for ACKR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ACKR2: view

Phenotypes for ACKR2 Gene

genes like me logo Genes that share phenotypes with ACKR2: view

Animal Models for ACKR2 Gene

MGI Knock Outs for ACKR2:

Animal Model Products

miRNA for ACKR2 Gene

miRTarBase miRNAs that target ACKR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACKR2 Gene

Localization for ACKR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACKR2 Gene

Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

Gene Ontology (GO) - Cellular Components for ACKR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with ACKR2: view

No data available for Subcellular locations from COMPARTMENTS for ACKR2 Gene

Pathways & Interactions for ACKR2 Gene

genes like me logo Genes that share pathways with ACKR2: view

Interacting Proteins for ACKR2 Gene

Selected Interacting proteins: O00590-ACKR2_HUMAN for ACKR2 Gene via I2D

Gene Ontology (GO) - Biological Process for ACKR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007275 multicellular organism development TAS 9364936
GO:0070098 chemokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with ACKR2: view

No data available for SIGNOR curated interactions for ACKR2 Gene

Drugs & Compounds for ACKR2 Gene

(1) Drugs for ACKR2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for ACKR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACKR2: view

Transcripts for ACKR2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ACKR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1:
SP2: - - - - - - - -
SP3:
SP4:
SP5: - -
SP6: - - - - - - - - -

Relevant External Links for ACKR2 Gene

GeneLoc Exon Structure for
ACKR2
ECgene alternative splicing isoforms for
ACKR2

Expression for ACKR2 Gene

mRNA expression in normal human tissues for ACKR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACKR2 Gene

This gene is overexpressed in Liver (x9.5) and Nerve - Tibial (x5.2).

Protein differential expression in normal tissues from HIPED for ACKR2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACKR2 Gene



mRNA Expression by UniProt/SwissProt for ACKR2 Gene

O00590-ACKR2_HUMAN
Tissue specificity: Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node.
genes like me logo Genes that share expression patterns with ACKR2: view

Protein tissue co-expression partners for ACKR2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ACKR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACKR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACKR2 35
  • 80.62 (n)
  • 80.8 (a)
CCBP2 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACKR2 35
  • 84.12 (n)
  • 82.2 (a)
ACKR2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ackr2 35
  • 76.04 (n)
  • 71.35 (a)
Ackr2 16
Ackr2 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCBP2 35
  • 99.05 (n)
  • 98.44 (a)
ACKR2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ackr2 35
  • 76.73 (n)
  • 72.7 (a)
chicken
(Gallus gallus)
Aves CCBP2 35
  • 57.5 (n)
  • 48.12 (a)
ACKR2 36
  • 43 (a)
OneToOne
Species with no ortholog for ACKR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACKR2 Gene

ENSEMBL:
Gene Tree for ACKR2 (if available)
TreeFam:
Gene Tree for ACKR2 (if available)

Paralogs for ACKR2 Gene

genes like me logo Genes that share paralogs with ACKR2: view

Variants for ACKR2 Gene

Sequence variations from dbSNP and Humsavar for ACKR2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2228468 - 42,865,620(+) GAACT(A/C/T)CCCTA reference, missense
rs2228467 - 42,864,624(+) TGCAG(C/T)GGTGT reference, missense
rs2228469 - 42,865,245(+) CCGGG(C/T)TTTAA reference, missense
rs6779520 - 42,865,433(+) CCATC(C/G)TGTAT reference, missense
rs1054138 -- 42,865,569(+) TGCCC(A/T)AGAGG reference, missense

Variation tolerance for ACKR2 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACKR2 Gene

HapMap Linkage Disequilibrium report
ACKR2
Human Gene Mutation Database (HGMD)
ACKR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ACKR2 Gene

Disorders for ACKR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACKR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cd45 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search ACKR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACKR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACKR2
genes like me logo Genes that share disorders with ACKR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACKR2 Gene

Publications for ACKR2 Gene

  1. Cloning and characterization of a novel promiscuous human beta- chemokine receptor D6. (PMID: 9405404) Nibbs R.J.B. … Graham G.J. (J. Biol. Chem. 1997) 2 3 4 67
  2. Chemokine decoy receptor d6 plays a negative role in human breast cancer. (PMID: 18708360) Wu F.Y. … Shao Z.M. (Mol. Cancer Res. 2008) 3 23
  3. Genetic variations of the chemokine scavenger receptor D6 are associated with liver inflammation in chronic hepatitis C. (PMID: 18822328) Wiederholt T. … Wasmuth H.E. (Hum. Immunol. 2008) 3 23
  4. The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. (PMID: 16014924) Neil S.J. … Weiss R.A. (J. Virol. 2005) 3 23
  5. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. (PMID: 12671049) Kunkel E.J. … Butcher E.C. (J. Clin. Invest. 2003) 3 23

Products for ACKR2 Gene

Sources for ACKR2 Gene

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