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Aliases for ACKR1 Gene

Aliases for ACKR1 Gene

  • Atypical Chemokine Receptor 1 (Duffy Blood Group) 2 3
  • DARC 3 4 6
  • GPD 3 4 6
  • FY 3 4 6
  • Duffy Blood Group, Atypical Chemokine Receptor 2 3
  • Duffy Blood Group, Chemokine Receptor 2 3
  • Atypical Chemokine Receptor 1 2 3
  • Plasmodium Vivax Receptor 3 4
  • Fy Glycoprotein 3 4
  • Glycoprotein D 3 4
  • WBCQ1 3 6
  • GpFy 3 4
  • Duffy Antigen/Chemokine Receptor 4
  • Duffy Blood Group Antigen 3
  • Duffy Blood Group 2
  • CD234 Antigen 4
  • CCBP1 3
  • CD234 3
  • Dfy 3

External Ids for ACKR1 Gene

Previous HGNC Symbols for ACKR1 Gene

  • FY
  • DARC

Summaries for ACKR1 Gene

Entrez Gene Summary for ACKR1 Gene

  • The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACKR1 Gene

ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR.

UniProtKB/Swiss-Prot for ACKR1 Gene

  • Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels

Gene Wiki entry for ACKR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACKR1 Gene

Genomics for ACKR1 Gene

Genomic Location for ACKR1 Gene

Start:
159,203,307 bp from pter
End:
159,206,500 bp from pter
Size:
3,194 bases
Orientation:
Plus strand

Genomic View for ACKR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACKR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACKR1 Gene

No data available for Regulatory Elements for ACKR1 Gene

Proteins for ACKR1 Gene

  • Protein details for ACKR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16570-ACKR1_HUMAN
    Recommended name:
    Atypical chemokine receptor 1
    Protein Accession:
    Q16570
    Secondary Accessions:
    • A8YPG5
    • O75898
    • Q16300
    • Q8WWE3
    • Q9UJP0
    • Q9UKZ5
    • Q9UKZ6
    • Q9UQE1

    Protein attributes for ACKR1 Gene

    Size:
    336 amino acids
    Molecular mass:
    35553 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACKR1 Gene

    Alternative splice isoforms for ACKR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACKR1 Gene

Proteomics data for ACKR1 Gene at MOPED

Post-translational modifications for ACKR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACKR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ACKR1 Gene

Domains for ACKR1 Gene

Gene Families for ACKR1 Gene

HGNC:
  • CD :CD molecules
  • ACKR :GPCR / Class A : Chemokine receptors : Atypical
  • bloodgroup :Blood group antigens

Protein Domains for ACKR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16570

UniProtKB/Swiss-Prot:

ACKR1_HUMAN :
  • Q16570
Family:
  • Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
genes like me logo Genes that share domains with ACKR1: view

No data available for Suggested Antigen Peptide Sequences for ACKR1 Gene

Function for ACKR1 Gene

Molecular function for ACKR1 Gene

UniProtKB/Swiss-Prot Function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels

Gene Ontology (GO) - Molecular Function for ACKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 7689250
GO:0004888 transmembrane signaling receptor activity TAS 9058825
GO:0004930 G-protein coupled receptor activity IEA --
GO:0019956 chemokine binding --
GO:0019957 C-C chemokine binding IPI 7517217
genes like me logo Genes that share ontologies with ACKR1: view

Phenotypes for ACKR1 Gene

genes like me logo Genes that share phenotypes with ACKR1: view

Animal Models for ACKR1 Gene

MGI Knock Outs for ACKR1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACKR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ACKR1 Gene

Localization for ACKR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACKR1 Gene

Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

Gene Ontology (GO) - Cellular Components for ACKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with ACKR1: view

No data available for Subcellular locations from COMPARTMENTS for ACKR1 Gene

Pathways for ACKR1 Gene

genes like me logo Genes that share pathways with ACKR1: view

Pathways by source for ACKR1 Gene

1 KEGG pathway for ACKR1 Gene

Gene Ontology (GO) - Biological Process for ACKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response NAS 10570183
GO:0006954 inflammatory response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032642 regulation of chemokine production IEA --
GO:0070098 chemokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with ACKR1: view

Compounds for ACKR1 Gene

(8) Novoseek inferred chemical compound relationships for ACKR1 Gene

Compound -log(P) Hits PubMed IDs
monophosphoryl lipid a 52.4 2
rantes 49.8 6
mannose 6-phosphate 33.7 3
glyceraldehyde 3-phosphate 3.17 2
phenylalanine 0 3
genes like me logo Genes that share compounds with ACKR1: view

Transcripts for ACKR1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACKR1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACKR1 Gene

No ASD Table

Relevant External Links for ACKR1 Gene

GeneLoc Exon Structure for
ACKR1
ECgene alternative splicing isoforms for
ACKR1

Expression for ACKR1 Gene

mRNA expression in normal human tissues for ACKR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ACKR1 Gene

mRNA Expression by UniProt/SwissProt for ACKR1 Gene

Q16570-ACKR1_HUMAN
Tissue specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium
genes like me logo Genes that share expressions with ACKR1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ACKR1 Gene

Orthologs for ACKR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACKR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DARC 35
  • 99.4 (n)
  • 99.11 (a)
DARC 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DARC 35
  • 75.66 (n)
  • 63.94 (a)
DARC 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DARC 35
  • 74.14 (n)
  • 65.15 (a)
DARC 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Darc 35
  • 71.07 (n)
  • 60.36 (a)
Darc 16
Darc 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Darc 35
  • 72.61 (n)
  • 61.52 (a)
chicken
(Gallus gallus)
Aves DARC 36
  • 29 (a)
OneToOne
Species with no ortholog for ACKR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACKR1 Gene

ENSEMBL:
Gene Tree for ACKR1 (if available)
TreeFam:
Gene Tree for ACKR1 (if available)

Paralogs for ACKR1 Gene

No data available for Paralogs for ACKR1 Gene

Variants for ACKR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ACKR1 Gene

Q16570-ACKR1_HUMAN
DARC is responsible for the Duffy blood group system (FY) [MIM:110700]. The molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and Asp-42 to Fy(B). Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to infection by the malarial parasite Plasmodium vivax. This allele is found predominantly in population of African origin [MIM:611162]

Sequence variations from dbSNP and Humsavar for ACKR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12075 Benign 159,205,564(+) CTATG(A/G)TGCCA missense, reference
rs13962 -- 159,205,737(+) TCCTG(A/G)CACAG missense, reference
rs14525 -- 159,206,432(+) GACAC(C/T)CTTGG reference, synonymous-codon
rs863001 -- 159,205,034(+) TTCCC(C/G)TGCTG upstream-variant-2KB, intron-variant
rs863002 -- 159,205,130(+) TCCTT(C/T)TCTCC upstream-variant-2KB, intron-variant

Relevant External Links for ACKR1 Gene

HapMap Linkage Disequilibrium report
ACKR1
Human Gene Mutation Database (HGMD)
ACKR1
Locus Specific Mutation Databases (LSDB)
DARC

No data available for Structural Variations from Database of Genomic Variants (DGV) for ACKR1 Gene

Disorders for ACKR1 Gene

(3) OMIM Diseases for ACKR1 Gene (613665)

(24) Novoseek inferred disease relationships for ACKR1 Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 83.4 75
pseudorabies 67 2
genital herpes 64.9 4
malaria vivax 59.2 3
viral shedding 56.5 1
genes like me logo Genes that share disorders with ACKR1: view

No data available for UniProtKB/Swiss-Prot for ACKR1 Gene

Publications for ACKR1 Gene

  1. Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. (PMID: 8248172) Chaudhuri A. … Pogo A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. (PMID: 7833467) Iwamoto S. … Ikemoto S. (Blood 1995) 3 4 23
  3. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals. (PMID: 9731074) Tournamille C. … Colin Y. (Blood 1998) 3 4 23
  4. Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites. (PMID: 12956774) Tournamille C. … Le Van Kim C. (Br. J. Haematol. 2003) 3 4 23
  5. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. (PMID: 7663520) Tournamille C. … Le van Kim C. (Nat. Genet. 1995) 2 3 4

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