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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACIN1 Gene

protein-coding GIFtS: 61
GCID: GC14M023527

apoptotic chromatin condensation inducer 1

(Previous name: apoptotic chromatin condensation inducer in the nucleus...)
(Previous symbol: ACINUS)

Explore 12 diseases affiliated with
ACIN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Apoptotic Chromatin Condensation Inducer 1¹ ²		FSAP152¹
ACINUS¹ ² ³		ACN² ⁵
KIAA0670¹ ³ ⁵		Functional Spliceosome-Associated Protein 152²
Apoptotic Chromatin Condensation Inducer In The Nucleus¹ ²		Acinus³

External Ids:	HGNC: 17066¹	Entrez Gene: 22985²	Ensembl: ENSG00000100813⁷	OMIM: 604562⁵	UniProtKB: Q9UKV3³

Export aliases for ACIN1 gene to outside databases

Previous GC identifers: GC14M021518 GC14M022597 GC14M003644

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACIN1:

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear

fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by

caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a

splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a

consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively

spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Oct

2011)

UniProtKB/Swiss-Prot: ACINU_HUMAN, Q9UKV3

Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on

mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and

cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent

mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not

cyclin A2, expression in leukemia cells

Gene Wiki entry for ACIN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACIN1 gene promoter:
SRF AP-1 SRF (504 AA) ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ACIN1 promoter sequence

Search SABiosciences Chromatin IP Primers for ACIN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACIN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

ACIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACIN1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M023527: view genomic region (about GC identifiers)

Start:	23,527,773 bp from pter	End:	23,564,823 bp from pter
Size:	37,051 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACINU_HUMAN, Q9UKV3 (See protein sequence)

Recommended Name: Apoptotic chromatin condensation inducer in the nucleus

Size: 1341 amino acids; 151862 Da

Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3,

MAGOH, PNN, RBM8A, RNPS1, SAP18 and ALYREF/THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex

with ACIN1, RNPS1 and SAP18. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner

Subcellular location: Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2

redistributes it from the nuclear speckles to the nucleoplasm

Secondary accessions: B2RTT4 D3DS45 O75158 Q9UG91 Q9UKV1 Q9UKV2

Alternative splicing: 4 isoforms: Q9UKV3-1 Q9UKV3-2 Q9UKV3-3 Q9UKV3-5

Explore the universe of human proteins at neXtProt for ACIN1: NX_Q9UKV3

Post-translational modifications:

Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1¹

Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UKV3

ACIN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001158286.1 NP_001158287.1 NP_001158288.1 NP_001158289.1 NP_055792.1

ENSEMBL proteins:

ENSP00000451138 ENSP00000345541 ENSP00000350073 ENSP00000262710 ENSP00000380502

ENSP00000451328 ENSP00000451410 ENSP00000405677

Reactome Protein details: Q9UKV3
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACIN1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0016607	nuclear speck	IEA	--

ACIN1 for ontologies About GeneDecksing

ACIN1 Antibody Products:

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	Uscn Antibodies for ACIN1
	ThermoFisher Antibodies for ACIN1

Assay Products for ACIN1:

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	GenScript Custom Assay Services for ACIN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ACIN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACIN1 for domains About GeneDecksing

3 InterPro domains/families:

IPR003034 SAP_dom

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry Q9UKV3

ProtoNet protein and cluster: Q9UKV3

1 Blocks protein family: IPB003034 DNA-binding SAP

UniProtKB/Swiss-Prot: ACINU_HUMAN, Q9UKV3

Similarity: Contains 1 SAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACINU_HUMAN, Q9UKV3

Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on

mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and

cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent

mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not

cyclin A2, expression in leukemia cells

miRNA Products:		OriGene 3'-UTR Clone (see all 5): ACIN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACIN1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ACIN1 (see all 18):
		hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-509-5p hsa-miR-340 hsa-miR-1205 hsa-miR-10b* hsa-miR-548a-3p hsa-miR-3165

		SwitchGear 3'UTR luciferase reporter plasmid: ACIN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ACIN1

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		GenScript: all cDNA clones in your preferred vector (see all 5): ACIN1 (NM_001164814)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ACIN1
		Search LifeMap BioReagents cell lines for ACIN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACIN1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	NAS	10490026
GO:0005515	protein binding	IPI	--
GO:0016887	ATPase activity	NAS	10490026
GO:0019899	enzyme binding	NAS	10490026

ACIN1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for ACIN1:

Decreased homologous recombina

G0/1 arrest

Increased G1 DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic cleavage of cellular proteins

Apoptotic cleavage of cellular proteins

1.00

Apoptotic execution phase

0.73

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

mRNA surveillance pathway

mRNA surveillance pathway

1.00

RNA transport

RNA transport

1.00

mRNA Splicing - Major Pathway

Spliceosome

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for ACIN1

Apoptosis and Autophagy

3 Reactome Pathways for ACIN1

	Apoptotic execution phase
	Apoptotic cleavage of cellular proteins
	Apoptosis

3 Kegg Pathways (Kegg details for ACIN1):

	RNA transport
	mRNA surveillance pathway
	Spliceosome

ACIN1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ACIN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/582 Interacting proteins for ACIN1 (Q9UKV3^{1, 2, 3} ENSP00000262710⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 582)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
API5	Q9BZZ5²^,³, ENSP00000399341⁴	MINT-7289283 MINT-7289297 MINT-7945693 MINT-7289318 MINT-7289249 MINT-7289353 I2D: score=1 STRING: ENSP00000399341
ABCF3	Q9NUQ8²^,³	MINT-7945693 MINT-65164 I2D: score=5
AKR1C3	P42330²^,³, ENSP00000369927⁴	MINT-63742 I2D: score=4 STRING: ENSP00000369927
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-50826 I2D: score=3 STRING: ENSP00000306330
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-50956 I2D: score=2 STRING: ENSP00000300161

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006200	ATP catabolic process	NAS	10490026
GO:0006915	apoptotic process	TAS	--
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	TAS	--
GO:0030218	erythrocyte differentiation	IEP	11208865
GO:0030263	apoptotic chromosome condensation	IDA	10490026

ACIN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACIN1
Search CenterWatch for drugs/clinical trials and news about ACIN1 / ACINU

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACIN1 gene (5 alternative transcripts):

NM_001164814.1 NM_001164815.1 NM_001164816.1 NM_001164817.1 NM_014977.3

Unigene Cluster for ACIN1:

Apoptotic chromatin condensation inducer 1

Hs.124490 [show with all ESTs]

Unigene Representative Sequence: NM_014977

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000557515(uc001wip.4) ENST00000473758(uc001wio.4) ENST00000338631

ENST00000357481(uc001wiq.4 uc001wir.4) ENST00000262710(uc001wit.4 uc010akg.3)

ENST00000397341 ENST00000555053 ENST00000555478 ENST00000555395 ENST00000554680

ENST00000553790 ENST00000556052 ENST00000555566 ENST00000557039 ENST00000555807

ENST00000553721 ENST00000557432 ENST00000555352

miRNA Products:		OriGene 3'-UTR Clone (see all 5): ACIN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACIN1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ACIN1 (see all 18):
		hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-509-5p hsa-miR-340 hsa-miR-1205 hsa-miR-10b* hsa-miR-548a-3p hsa-miR-3165

		SwitchGear 3'UTR luciferase reporter plasmid: ACIN1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACIN1

Additional cDNA sequence:

AB014570.2 AF124726.1 AF124727.1 AF124728.1 AK299034.1 AL050382.1 AL833228.1 BC032770.1

BC140805.1 BX247975.1

24/37 DOTS entries (see all 37):

DT.100828728 DT.100703400 DT.100828733 DT.100828730 DT.441873 DT.99952589 DT.91757510 DT.91828716

DT.95178277 DT.120788380 DT.91716345 DT.101969332 DT.91939335 DT.100807424 DT.120788322 DT.120788320

DT.92068352 DT.100828734 DT.40213840 DT.91640659 DT.95256792 DT.95259771 DT.100029093 DT.100770311

24/360 AceView cDNA sequences (see all 360):

BM682134 BM848419 AV654160 W56290 AA250772 AI580963 AL121100 AA369024

AL040359 CB159191 BM797142 AI888536 BP364216 CB053500 AF124726 BQ652996

BM476144 CK724858 BF197086 BQ646643 BQ424346 BU902235 AA283206 AF124728

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ACIN1 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14
SP1:
SP2:																									-		-		-				-		-		-		-
SP3:									-
SP4:																									-				-				-		-
SP5:

ECgene alternative splicing isoforms for ACIN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACIN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTAAAGAA

About this image
See ACIN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACIN1

SOURCE GeneReport for Unigene cluster: Hs.124490

UniProtKB/Swiss-Prot: ACINU_HUMAN, Q9UKV3

Tissue specificity: Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in

patients with myeloid hematologic malignancies

SABiosciences Custom PCR Arrays for ACIN1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACIN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACIN1 gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Acin1^{1 , 5}	apoptotic chromatin condensation inducer 1^{1, 5}	86.95(n)¹ 86.87(a)¹		14 (27.87 cM)⁵ 56215¹ NM_023190.3¹ NP_075679.2¹ 54642161⁵
lizard (Anolis carolinensis)	Reptilia	ACIN1⁶	--	51(a)	1 ↔ 1	GL343776.1(88829-116811)
African clawed frog (Xenopus laevis)	Amphibia	48015632²	--	76.28(n)		48015632
zebrafish (Danio rerio)	Actinopterygii	Dr.12550²	Danio rerio, clone IMAGE2601128, mRNA	74.14(n)		BC045312.1
fruit fly (Drosophila melanogaster)	Insecta	Acn¹	Acinus	43.01(n) 34.07(a)		35173 NM_165273.1 NP_724153.1
worm (Caenorhabditis elegans)	Secernentea	acin-1¹	Protein ACIN-1	41.7(n) 30.43(a)		172030 NM_058943.4 NP_491344.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G39680⁶	SAP domain-containing protein	19(a)	1 ↔ 1	4(18414306-18417530)
rice (Oryza sativa)	Liliopsida	-- --	SAP domain containing protein, expressed	18(a) 18(a)	many → 1 many → 1	7(25932054-25935546) 3(15212844-15217717)

ENSEMBL Gene Tree for ACIN1 (if available)
TreeFam Gene Tree for ACIN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3751499^1,2	C,H	--	3644623(+)	`TAAAGG/CAACAC`	5	--	ds500¹		4		NS EA	418
rs1052922^1,2	H	--	3644822(-)	`TATCCA/CCCTTT`	5	--	ut3¹		6		NS EA NA	422
rs1052881^1,2	C	--	3644874(-)	`CCAGTC/TTCTTC`	5	--	ut3¹ ese³		3		MN NA	188
rs111474630^1,2		--	3645754(+)	`AAGGGG/CTTGGG`	5	--	int¹		2		CSA WA	120
rs11844438^1,2	C,H,	--	3646204(+)	`tgtggT/Cctccg`	5	--	int¹		3		NA WA	240
rs2012588^1,2	C,F,	--	3646366(+)	`GAGGCT/ATAGAT`	5	--	int¹		4		NA CSA WA	242
rs113051660^1,2		--	3646648(+)	`CACGAC/TTTCTC`	5	--	int¹		1		CSA	2
rs113696515^1,2		--	3646771(+)	`CTCCCG/TGGTTC`	5	--	int¹		1		CSA	2
rs57679347^1,2		--	3646831(+)	`GCCACC/TGCACC`	5	--	int¹		0	--	--	--	--
rs112612285^1,2		--	3647169(+)	`ACTCTC/TGCAGT`	5	--	int¹		1		CSA	2

HapMap Linkage Disequilibrium report for ACIN1 (23527773 - 23564823 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACIN1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ACIN1 for disorders           About GeneDecksing

OMIM gene information: 604562    OMIM disorders: --

12 diseases for ACIN1:    About MalaCards

acne congenital diaphragmatic hernia sialolithiasis tick paralysis

hernia cholestasis gastric adenocarcinoma adenocarcinoma

lung adenocarcinoma prostate cancer prostatitis leukemia

1 disease from the University of Copenhagen DISEASES database for ACIN1:

Breast adenomyoepithelioma

Human Genome Epidemiology (HuGE) Navigator: ACIN1 (1 document)

Export disorders for ACIN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ACIN1 gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with ACIN1)

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Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. (PubMed id 10490026)^{1, 2, 3, 9} Sahara S.... Tsujimoto Y. (1999)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2, 3} Ishikawa K.... Ohara O. (1998)
The antiapoptotic protein AAC-11 interacts with and regulates Acinus- mediated DNA fragmentation. (PubMed id 19387494)^{1, 2, 9} Rigou P....Poyet J.-L. (2009)
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)^{1, 2} Denis N.J.... Figeys D. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. (PubMed id 16537548)^{1, 9} Joselin A.P....Schwerk C. (2006)
A critical role for AKT activation in protecting cell s from ionizing radiation-induced apoptosis and the regulation of acinus gene e xpression. (PubMed id 19615784)^{1, 9} Park H.S....Nam S.Y. (2009)
Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. (PubMed id 16177823)^{1, 9} Hu Y....Ye K. (2005)
NGF inhibits human leukemia proliferation by downregu lating cyclin A1 expression through promoting acinus/CtBP2 association. (PubMed id 19668232)^{1, 9} Chan C.B....Ye K. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22985	HGNC: 17066	AceView: ACIN1	Ensembl:ENSG00000100813	euGenes: HUgn22985
ECgene: ACIN1	Kegg: 22985	H-InvDB: ACIN1

(According to HUGE)
About This Section

HUGE: KIAA0670

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ACIN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACIN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACIN1 gene:
Search GeneIP for patents involving ACIN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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apoptotic chromatin condensation inducer 1

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apoptotic chromatin condensation inducer 1

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