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ACHE Gene

protein-coding   GIFtS: 69
GCID: GC07M100487

Acetylcholinesterase (Yt Blood Group)

(Previous names: acetylcholinesterase (YT blood group), acetylcholinesterase...)
(Previous symbol: YT)
  See ACHE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acetylcholinesterase (Yt Blood Group)1 2     ARACHE2
YT1 2 5     N-ACHE2
acetylcholinesterase1 2     Apoptosis-Related Acetylcholinesterase2
Yt Blood Group1 2     AChE3
EC 3.1.1.73 8     EC 3.1.18
ACEE2     

External Ids:    HGNC: 1081   Entrez Gene: 432   Ensembl: ENSG000000870857   OMIM: 1007405   UniProtKB: P223033   

Export aliases for ACHE gene to outside databases

Previous GC identifers: GC07M099022 GC07M100085 GC07M100099 GC07M100132 GC07M100325 GC07M095117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACHE Gene:
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain
cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes,
where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which
possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the
cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises
from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The
major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which
forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other,
alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and
contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the
phosphoinositide (PI) moieties added post-translationally. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACHE Gene:
ACHE (acetylcholinesterase (Yt blood group)) is a protein-coding gene. Diseases associated with ACHE include gastroschisis, and aplasia cutis congenita. GO annotations related to this gene include collagen binding and protein homodimerization activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: ACES_HUMAN, P22303
Function: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine
released into the synaptic cleft. Role in neuronal apoptosis

summary for ACHE Gene:
Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and
acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst
butyrylcholinesterase is mostly expressed in the liver. The high enzymatic rate of AChE means that it
effectively terminates signal transmission at cholinergic synpases. AChE is the target of organophosphate
nerve agents such as sarin and VX. Clinically, AChE inhibitors have found a number of uses, with
physostigmine used to treat glaucoma. AChE inhibitors are also used in the management of mild to moderate
Alzheimer's disease.

Gene Wiki entry for ACHE (Acetylcholinesterase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACHE gene promoter:
         TBP   Sp1   Egr-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACHE promoter sequence
   Search Chromatin IP Primers for ACHE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACHE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

ACHE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACHE gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100487:  view genomic region     (about GC identifiers)

Start:
100,487,615 bp from pter      End:
100,494,594 bp from pter
Size:
6,980 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,847,220-99,853,146     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACES_HUMAN, P22303 (See protein sequence)
Recommended Name: Acetylcholinesterase precursor  
Size: 614 amino acids; 67796 Da
Subunit: Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells
and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T
generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms,
in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to
cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ,
which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric
Selected PDB 3D structures from and Proteopedia for ACHE (see all 16):
1B41 (3D)        1F8U (3D)        1PUV (3D)        1PUW (3D)        1VZJ (3D)        2CLJ (3D)    
Secondary accessions: A4D2E2 B7ZKZ0 D6W5X7 Q16169 Q29S23 Q2M324 Q504V3 Q53F46 Q86TM9 Q86YX9
Q9BXP7
Alternative splicing: 4 isoforms:  P22303-1   P22303-2   P22303-4   P22303-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACHE: NX_P22303

Explore proteomics data for ACHE at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn296, Asn381, Asn495
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACHE (P22303) (see all 27)
     AFGFLAL  HGYEIEF  LALQWVQ  PNGPWAT 


    See ACHE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000656.1  NP_001269378.1  NP_056646.1  

    ENSEMBL proteins: 
     ENSP00000403474   ENSP00000241069   ENSP00000414858   ENSP00000394976   ENSP00000397143  
     ENSP00000390004   ENSP00000410380   ENSP00000399725   ENSP00000415901   ENSP00000404865  
     ENSP00000396360   ENSP00000400933   ENSP00000303211  
    Reactome Protein details: P22303

    ACHE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ACHE (Acetylcholinesterase/ACHE)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACHE
    OriGene Protein Over-expression Lysate for ACHE
    OriGene MassSpec for ACHE
    OriGene Custom Protein Services for ACHE
    GenScript Custom Purified and Recombinant Proteins Services for ACHE
    Novus Biologicals ACHE Proteins
    Novus Biologicals ACHE Lysates
    Sino Biological Recombinant Protein for ACHE
    Sino Biological Cell Lysate for ACHE
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ACHE 

    ACHE Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ACHE
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    OriGene Antibodies for ACHE
    OriGene Custom Antibody Services for ACHE
    Novus Biologicals ACHE Antibodies
    Abcam antibodies for ACHE
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ACHE
    LSBio Antibodies in human, mouse, rat for ACHE

    ACHE Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACHE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ACHE 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bloodgroup: Blood group antigens

    5 InterPro protein domains:
     IPR019826 Carboxylesterase_B_AS
     IPR014788 AChE_tetra
     IPR000997 Cholinesterase
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry P22303

    ProtoNet protein and cluster: P22303

    1 Blocks protein domain: IPB000997 Cholinesterase signature

    UniProtKB/Swiss-Prot: ACES_HUMAN, P22303
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    Find genes that share domains with ACHE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACES_HUMAN, P22303
    Function: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine
    released into the synaptic cleft. Role in neuronal apoptosis
    Catalytic activity: Acetylcholine + H(2)O = choline + acetate

         Genatlas biochemistry entry for ACHE:
    acetylcholinesterase

         Enzyme Numbers (IUBMB): EC 3.1.1.71 2 EC 3.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding TAS11283752
    GO:0003990acetylcholinesterase activity IMP1517212
    GO:0004104cholinesterase activity IDA1517212
    GO:0005515protein binding IPI10800960
    GO:0005518collagen binding IDA12524166
         
    Find genes that share ontologies with ACHE           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ache):
     adipose tissue  behavior/neurological  craniofacial  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     no phenotypic analysis  reproductive system  respiratory system  vision/eye 

    Find genes that share phenotypes with ACHE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ACHE: Achetm4Pata Achetm4.1Pata Achetm1.1Hssh Achetm3Pata Achetm1Loc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACHE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACHE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACHE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACHE

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ACHE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACHE (see all 13):
    hsa-miR-4324 hsa-miR-3184 hsa-miR-125a-5p hsa-miR-3065-5p hsa-miR-423-5p hsa-miR-587 hsa-miR-124 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidACHE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACHE
    Predesigned siRNA for gene silencing in human, mouse, rat ACHE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACHE

    Clone
    Products:
         
    OriGene clones in human, mouse for ACHE (see all 13)
    OriGene ORF clones in mouse, rat for ACHE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACHE (NM_015831)
    Sino Biological Human cDNA Clone for ACHE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACHE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACHE

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACHE
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACHE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACHE

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12334) for ACHE 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACES_HUMAN, P22303: Cell junction, synapse. Secreted (By similarity). Cell membrane; Peripheral membrane protein
    (By similarity)
    ACES_HUMAN, P22303: Isoform T: Nucleus. Note=Only observed in apoptotic nuclei
    ACES_HUMAN, P22303: Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS11283752
    GO:0005605basal lamina NAS16289501
    GO:0005615extracellular space IBA--
    GO:0005634nucleus IEA--
    GO:0005788endoplasmic reticulum lumen IBA--

    Find genes that share ontologies with ACHE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACHE About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    Synthesis of PC0.00
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neurotransmitter Clearance In The Synaptic Cleft0.00
    Neuronal System0.68
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Synthesis, Secretion, and Deacylation of Ghrelin0.00
    5Circadian entrainment
    Cholinergic synapse0.37


    Find genes that share SuperPaths with ACHE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for ACHE
        Biogenic Amine Synthesis
    Acetylcholine Synthesis
    Monoamine Transport
    Integrated Pancreatic Cancer Pathway
    ATF-2 transcription factor network


    3 Reactome Pathways for ACHE
        Synthesis, secretion, and deacylation of Ghrelin
    Neurotransmitter Clearance In The Synaptic Cleft
    Synthesis of PC

    1 PharmGKB Pathway for ACHE
        Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

    2 Kegg Pathways  (Kegg details for ACHE):
        Glycerophospholipid metabolism
    Cholinergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACHE: 
              Neurogenesis in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ACHE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for ACHE (P223031, 2, 3 ENSP000003032114) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COLQQ9Y2151, 3, ENSP000003732984EBI-1637793,EBI-1637847 I2D: score=3 STRING: ENSP00000373298
    GNB2L1P632441, 3, ENSP000003660134EBI-1637793,EBI-296739 I2D: score=1 STRING: ENSP00000366013
    ENO1P067331, 3, ENSP000002345904EBI-1637793,EBI-353877 I2D: score=1 STRING: ENSP00000234590
    APPP050673, ENSP000002849814I2D: score=3 STRING: ENSP00000284981
    LAMB1P079423, ENSP000002223994I2D: score=2 STRING: ENSP00000222399
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001507acetylcholine catabolic process in synaptic cleft NAS1517212
    GO:0001919regulation of receptor recycling IEA--
    GO:0002076osteoblast development IEP15454088
    GO:0006260DNA replication TAS11283752
    GO:0006581acetylcholine catabolic process IDA1517212

    Find genes that share ontologies with ACHE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ACHE
      Browse compounds at ApexBio 

    Compounds for ACHE available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Donepezil hydrochloridePotent AChE inhibitor[120011-70-3]
    PhenserineCholinesterase inhibitor[101246-66-6]
    Galanthamine hydrobromideCholinesterase inhibitor[1953-04-4]
    Rivastigmine tartrateDual AChE and BChE inhibitor[129101-54-8]
    AcephateAnticholinesterase insecticide[30560-19-1]

    5 HMDB Compounds for ACHE    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    AcetylcholineACh (see all 7)51-84-3--
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    DonepezilAricept (see all 3)120014-06-4--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected DrugBank Compounds for ACHE (see all 49)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Galantamine(-)-Galanthamine (see all 3)357-70-0targetinhibitor10971049 12137632 10606746 11129124 10762042 11752352 12481195 20480924 11078030 10592235 12177686 10971048 1026294
    Rivastigmine-- 123441-03-2targetinhibitor18671661 12636181 19470293 11139819 19370562 10673128 10713582 11752352 18044073 10587286 14587496 11078030
    TacrineTetrahydroaminacrine (see all 5)321-64-2targetinhibitor10210906 12871155 10513568 10024872 17218977 15544504 15544507 11752352 10375753 16880719 16860785 10208549
    Donepezil-- 120014-06-4targetinhibitor20193764 10513568 10641971 10024872 11893059 11752352 10466911 10368299 20522977
    Ambenonium-- 7648-98-8targetinhibitor11330337 2857786 11752352 5833399 1588924 13679187 15982786
    EdrophoniumEDR (see all 5)116-38-1targetinhibitor10089512 10103097 11752352 10363282 19472276 10421446 10433700
    Neostigmine-- 59-99-4targetinhibitor19257799 10826417 11752352 12522088 12726885 11819669 11313435
    Gallamine TriethiodideBenzcurine Iodide (see all 9)65-29-2targetinhibitor1207670 17944454 10421444 417864 11920914 3190453
    IsoflurophateDFP (see all 4)55-91-4targetinhibitor10898598 1692236 11752352 12837382 10378121 11350858
    PhysostigmineErserine (see all 4)57-47-6targetinhibitor11141093 10873710 10741458 10403635 11752352 10368402

    Selected Novoseek inferred chemical compound relationships for ACHE gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    donepezil 93.8 464 18587286 (6), 11068139 (5), 19935404 (5), 12454562 (4) (see all 99)
    galantamine 93.2 293 1954303 (6), 9839013 (3), 19969445 (3), 12635450 (3) (see all 99)
    acetylthiocholine 92.9 110 10869180 (3), 9427520 (2), 11275256 (2), 18602908 (2) (see all 68)
    rivastigmine 92.6 264 9737824 (8), 10587286 (5), 12454562 (4), 15275830 (4) (see all 99)
    obidoxime 92.2 140 14985944 (4), 18588863 (3), 15498514 (3), 19429253 (3) (see all 73)
    tacrine 91 286 1538717 (6), 2023867 (4), 1954303 (4), 8186246 (4) (see all 99)
    pralidoxime 90.8 116 11180275 (4), 9587020 (3), 18254274 (2), 18676153 (2) (see all 71)
    oxime 88.9 448 20028185 (7), 15498514 (6), 17900152 (6), 16904809 (5) (see all 99)
    thiocholine 88.5 33 15987132 (2), 19238297 (2), 15826103 (1), 17499494 (1) (see all 22)
    acetylcholine 88.3 981 2096961 (4), 9489729 (4), 10576601 (3), 1819171 (3) (see all 99)



    Find genes that share compounds with ACHE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACHE gene (3 alternative transcripts): 
    NM_000665.3  NM_001282449.1  NM_015831.2  

    Unigene Cluster for ACHE:

    Acetylcholinesterase
    Hs.154495  [show with all ESTs]
    Unigene Representative Sequence: NM_015831
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419336(uc003uxj.1) ENST00000241069 ENST00000428317(uc003uxi.3)
    ENST00000412389(uc003uxd.3) ENST00000426415 ENST00000454485 ENST00000440755
    ENST00000430554 ENST00000442452 ENST00000411582 ENST00000441605 ENST00000445236
    ENST00000497647 ENST00000302913(uc003uxe.3 uc003uxf.3 uc003uxg.3 uc003uxh.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat ACHE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACHE (see all 13):
    hsa-miR-4324 hsa-miR-3184 hsa-miR-125a-5p hsa-miR-3065-5p hsa-miR-423-5p hsa-miR-587 hsa-miR-124 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidACHE 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ACHE
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    OriGene ORF clones in mouse, rat for ACHE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACHE (NM_015831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACHE
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    Additional mRNA sequence: 

    AF334270.1 AK223443.1 AK291321.1 AY389977.1 BC026315.1 BC036813.1 BC094752.1 BC105060.1 
    BC105062.1 BC143469.1 M55040.1 

    11 DOTS entries:

    DT.416657  DT.121041597  DT.100751908  DT.100751910  DT.101984170  DT.121041603  DT.75103919  DT.97776847 
    DT.121041601  DT.101984168  DT.101984171 

    Selected AceView cDNA sequences (see all 134):

    BI753192 BC001541 BM719818 CK904419 BC036813 H38691 BE551703 AI360141 
    CD014073 CD014074 CD014071 CD014075 BQ225068 CD014072 BM023149 BE466391 
    CA394873 CD014076 AA401251 AI081892 BM545507 AF334270 BI915019 AI081808 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACHE (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:        -     -                                                                 -               
    SP2:              -                             -     -     -                       -               
    SP3:              -                                                                 -               
    SP4:                                            -     -                             -               
    SP5:                                                                                -               


    ECgene alternative splicing isoforms for ACHE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACHE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ACHE Expression
    About this image


    ACHE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    ACHE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACHE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154495

    UniProtKB/Swiss-Prot: ACES_HUMAN, P22303
    Tissue specificity: Isoform H is highly expressed in erythrocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACHE: 
              Neurogenesis in human mouse rat
              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ACHE gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ache1 , 5 acetylcholinesterase1, 5 84.91(n)1
    88.44(a)1
      5 (76.32 cM)5
    114231  NM_009599.31  NP_033729.11 
     1372875195 
    chicken
    (Gallus gallus)
    Aves ACHE1 acetylcholinesterase 64.66(n)
    64.2(a)
      396388  NM_205418.1  NP_990749.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 10)
    Uncharacterized protein
    (see all 10)
    41(a)
    41(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    2(192438891-192450501)
    2(192421480-192427408)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89632 Xenopus laevis transcribed sequence with weak similarity more 71.5(n)    CB563700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ache2 acetylcholinesterase 73.74(n)   114549  NM_131846.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Est83 carboxylesterase 36(a)
    (best of 26)
      3 84D9   --
    worm
    (Caenorhabditis elegans)
    Secernentea R173.33
    ace-11
    esterase3
    ace-11
    42(a)
    (best of 15)3
    47.89(n)1
    43.3(a)1
      X(7065997-7071293)3
    1817061  NM_078259.61  NP_510660.11 


    ENSEMBL Gene Tree for ACHE (if available)
    TreeFam Gene Tree for ACHE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACHE gene
    NLGN12  CES22  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN32  NLGN22  
    CES12  CEL2  CES5A2  BCHE2  
    15 SIMAP similar genes for ACHE using alignment to 11 protein entries:     ACES_HUMAN (see all proteins):
    BCHE    CES1P1    CES4A    CES3    TG    CES2
    NLGN3    DKFZp686F02202    CES5A    CES hBr2    CES8    CEL
    CES1    NLGN4X    NLGN2

    Find genes that share paralogs with ACHE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ACES_HUMAN, P22303: ACHE is responsible for the Yt blood group system [MIM:112100]. The molecular basis of the
    Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353 corresponds to Yt(a) and
    the rare variant with Asn-353 to Yt(b)


    Selected SNPs for ACHE (see all 262)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17998051,2,,4
    C,F,Hnon-pathogenic199850402(-) ACTTCC/AACGGC 4 /N /H mis1 ese318Minor allele frequency- A:0.03MN NS EA NA EU 7462
    rs27339181,2
    C,H--99846740(+) CGGGAG/ACGGAT 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs27339191,2
    H--99846745(+) ACGGAG/TGTCCC 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs178858231,2
    C,F--99846906(-) GGTGGC/TTGCCT 2 -- ds50012Minor allele frequency- T:0.04NS 92
    rs178807001,2
    C,F--99846922(-) TCGGTC/AGGTGC 2 -- ds50013Minor allele frequency- A:0.09NS NA 92
    rs22516311,2
    C,A--99846967(-) aggggA/Cggggc 2 -- ds50010--------
    rs2001826521,2
    --99846968(+) CCCCG-/CCCCTCCCC
    TCCCCTCCCCT
    CCCCT
    1 -- ds50010--------
    rs49961641,2
    C--99846979(+) ccctcC/Tcctcc 2 -- ds50010--------
    rs624825121,2
    --99846984(+) CCCTCC/TCCTCC 2 -- ds50010--------
    rs1427936471,2
    C--99846987(+) TCCCCG/TCCCCT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ACHE (100487615 - 100494594 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ACHE:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    dgv7403n71CNV Loss21882294
    dgv7408n71CNV Loss21882294
    dgv7404n71CNV Loss21882294
    nsv831073CNV Loss17160897
    dgv7405n71CNV Loss21882294
    dgv7406n71CNV Loss21882294
    dgv7407n71CNV Loss21882294
    nsv482110CNV Gain20164927
    dgv2119e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ACHE
    Locus Specific Mutation Databases (LSDB): ACHE

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACHE
    DNA2.0 Custom Variant and Variant Library Synthesis for ACHE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 100740   
    OMIM disorders: 112100  
    Selected diseases for ACHE (see all 30):    
    About MalaCards
    gastroschisis    aplasia cutis congenita    colonic pseudo-obstruction    hypoganglionosis
    abdominal wall defect    wernicke-korsakoff syndrome    vascular dementia    myasthenia gravis
    endplate acetylcholinesterase deficiency    cholinergic urticaria    postural hypotension    rem sleep behavior disorder
    omphalocele    intestinal pseudo-obstruction    memory impairment    anencephaly
    hypohidrosis    anhidrosis    orthostatic intolerance    megacolon


    Find genes that share disorders with ACHE           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ACHE gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 89 829 1469405 (5), 17553629 (4), 9269216 (4), 12669110 (4) (see all 99)
    acetylcholinesterase expression 83.2 30 17000130 (5), 17320203 (4), 12707285 (2), 1692114 (1) (see all 20)
    endplate acetylcholinesterase deficiency 81.6 14 12609505 (3), 16009904 (1), 18647752 (1), 18374322 (1) (see all 9)
    myasthenic syndromes congenital 79.3 22 12609505 (2), 9758617 (2), 15248101 (1), 16009904 (1) (see all 13)
    hirschsprung disease 78.5 96 11528605 (4), 14680278 (3), 8747488 (3), 11719866 (3) (see all 46)
    poisoning 76.8 185 15065394 (4), 10477195 (3), 16601804 (2), 18281016 (2) (see all 93)
    dementia 76.1 180 1469405 (4), 9351648 (4), 8951800 (3), 14676050 (3) (see all 99)
    senile plaques 69.6 93 1703383 (3), 9282941 (3), 9062656 (3), 1717194 (2) (see all 46)
    dementia vascular 64.5 18 17215726 (2), 15224429 (1), 18174021 (1), 20110698 (1) (see all 15)
    intoxication 63.5 75 16601804 (2), 18045198 (2), 17194020 (2), 20028185 (2) (see all 48)

    Genetic Association Database (GAD): ACHE
    Human Genome Epidemiology (HuGE) Navigator: ACHE (32 documents)

    Export disorders for ACHE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ACHE gene, integrated from 10 sources (see all 2382):
    (articles sorted by number of sources associating them with ACHE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. (PubMed id 1517212)1, 2, 9 Shafferman A.... Barak D. (J. Biol. Chem. 1992)
    2. Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. (PubMed id 8299725)1, 2, 9 Karpel R.... Soreq H. (Exp. Cell Res. 1994)
    3. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. (PubMed id 17503475)1, 4, 9 Piccardi M....Del Zompo M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    4. Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities. (PubMed id 15715671)1, 4, 9 Bryk B....Soreq H. (J. Neurochem. 2005)
    5. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. (PubMed id 15690550)1, 4, 9 Cook L.J....Rubinsztein D.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005)
    6. Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin- II. (PubMed id 11053835)1, 2, 9 Kryger G....Sussman J.L. (Acta Crystallogr. D 2000)
    7. Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine. (PubMed id 18780301)1, 4, 9 Scacchi R....Corbo R.M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    8. Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. (PubMed id 15974920)1, 4, 9 Hasin Y....Sussman J.L. (Curr Alzheimer Res 2005)
    9. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PubMed id 21490949)1, 4 Sim X....Tai E.S. (PLoS Genet. 2011)
    10. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 43 HGNC: 108 AceView: ACHE Ensembl:ENSG00000087085 euGenes: HUgn43
    ECgene: ACHE Kegg: 43 H-InvDB: ACHE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ACHE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACHE Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=yt
    Wikipedia http://en.wikipedia.org/wiki/Acetylcholinesterase
    SeattleSNPshttp://pga.gs.washington.edu/data/ache/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACHE gene:
    Search GeneIP for patents involving ACHE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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