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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACER3 Gene

protein-coding GIFtS: 57
GCID: GC11P076571

Alkaline Ceramidase 3

(Previous names: phytoceramidase, alkaline)
(Previous symbol: PHCA)

7 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Alkaline Ceramidase 3¹ ²		Alkaline Dihydroceramidase SB89² ³
PHCA¹ ² ³		AlkCDase 3² ³
Alkaline Phytoceramidase¹ ² ³		APHC² ³
Phytoceramidase, Alkaline¹ ²		EC 3.5.1.-³
Alkaline CDase 3² ³		aPHC³

External Ids:	HGNC: 16066¹	Entrez Gene: 55331²	Ensembl: ENSG00000078124⁷	UniProtKB: Q9NUN7³

Export aliases for ACER3 gene to outside databases

Previous GC identifers: GC11P076250 GC11P072869

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ACER3 Gene:

ACER3 (alkaline ceramidase 3) is a protein-coding gene. Diseases associated with ACER3 include lipogranulomatosis, and farber lipogranulomatosis, and among its related super-pathways are Sphingolipid metabolism and Metabolic pathways. GO annotations related to this gene include phytoceramidase activity.

UniProtKB/Swiss-Prot: ACER3_HUMAN, Q9NUN7

Function: Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity

Gene Wiki entry for ACER3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NT_167190.1 NC_018922.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACER3 gene promoter:
STAT1 Pax-6 YY1 Evi-1 C/EBPalpha RORalpha1 Pax-3 c-Myb ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACER3 promoter sequence

Search SABiosciences Chromatin IP Primers for ACER3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACER3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.5

ACER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACER3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P076571: view genomic region (about GC identifiers)

Start:	76,571,911 bp from pter	End:	76,737,841 bp from pter
Size:	165,931 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACER3_HUMAN, Q9NUN7 (See protein sequence)

Recommended Name: Alkaline ceramidase 3

Size: 267 amino acids; 31552 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass

membrane protein

Secondary accessions: B2RC99

Alternative splicing: 2 isoforms: Q9NUN7-1 Q9NUN7-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACER3: NX_Q9NUN7

Explore proteomics data for ACER3 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9NUN7

ACER3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_060837.3

ENSEMBL proteins:

ENSP00000435733 ENSP00000434480 ENSP00000432109 ENSP00000432379 ENSP00000433368

ENSP00000435048 ENSP00000431149 ENSP00000436252 ENSP00000431504 ENSP00000278544

ENSP00000440916 ENSP00000440663

Reactome Protein details: Q9NUN7
Human Recombinant Protein Products for ACER3:

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	Cloud-Clone Corp. Proteins for ACER3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral to membrane	--	--
GO:0030173	integral to Golgi membrane	IDA	11356846
GO:0030176	integral to endoplasmic reticulum membrane	IDA	11356846

ACER3 for ontologies About GeneDecksing

ACER3 Antibody Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ACER: Alkaline ceramidase

1 InterPro protein domain:

IPR008901 Ceramidase

Graphical View of Domain Structure for InterPro Entry Q9NUN7

ProtoNet protein and cluster: Q9NUN7

2 Blocks protein domains:

IPB002222 Ribosomal protein S19/S15

IPB008901 Alkaline phytoceramidase

UniProtKB/Swiss-Prot: ACER3_HUMAN, Q9NUN7

Similarity: Belongs to the alkaline ceramidase family

ACER3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ACER3_HUMAN, Q9NUN7

Function: Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity

Enzyme regulation: Activated by Ca(2+) and inhibited by Zn(2+)

Enzyme Number (IUBMB): EC 3.5.1.-¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	--	--
GO:0070774	phytoceramidase activity	IDA	11356846

ACER3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ACER3:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for ACER3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACER3

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACER3
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ACER3 (see all 43):
		hsa-let-7d hsa-miR-4328 hsa-miR-3653 hsa-miR-578 hsa-let-7g hsa-miR-649 hsa-let-7a hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: ACER3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene clones in human, mouse for ACER3 (see all 5) OriGene ORF clones in mouse, rat for ACER3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ACER3 (NM_018367)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACER3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ACER3 About

See pathways by source

SuperPath

Contained pathways About

Sphingolipid metabolism

	Sphingolipid metabolism	0.63			Sphingolipid de novo biosynthesis	0.47
	Sphingolipid metabolism	0.63

Metabolism

Metabolism

0.40

Metabolism of lipids and lipoproteins

0.34

Pathways by source See SuperPaths
Show all pathways

4 Reactome Pathways for ACER3

	Sphingolipid metabolism
	Metabolism
	Metabolism of lipids and lipoproteins
	Sphingolipid de novo biosynthesis

1 Kegg Pathway (Kegg details for ACER3):

Sphingolipid metabolism

ACER3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ACER3

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/41 Interacting proteins for ACER3 (Q9NUN7³ ENSP00000278544⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGPAT1	Q99943³	I2D: score=1
ENSG00000206324	Q99943³	I2D: score=1
ENSG00000226467	Q99943³	I2D: score=1
ENSG00000227642	Q99943³	I2D: score=1
ENSG00000228892	Q99943³	I2D: score=1

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0006672	ceramide metabolic process	IEA	--
GO:0008284	positive regulation of cell proliferation	IMP	--
GO:0030148	sphingolipid biosynthetic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

ACER3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACER3

2 HMDB Compounds for ACER3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Dihydroceramide	N-Acylsphinganine (see all 2)	--	--
Sphinganine	2-amino-D-erythro-1,3-Octadecanediol (see all 13)	764-22-7	--

Search CenterWatch for drugs/clinical trials and news about ACER3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACER3 gene:

NM_018367.5

Unigene Cluster for ACER3:

Alkaline ceramidase 3

Hs.23862 [show with all ESTs]

Unigene Representative Sequence: NM_018367

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534206 ENST00000532485(uc009yum.1 uc001oxu.2 uc009yun.1 uc009yuo.1 uc010rsh.1 uc010rsi.1 uc010rsj.1)

ENST00000530182 ENST00000525194(uc009yul.1) ENST00000525861 ENST00000531461

ENST00000530334(uc010rsg.1) ENST00000526597 ENST00000533873 ENST00000531352

ENST00000278544 ENST00000527508 ENST00000525325 ENST00000530921 ENST00000538157

ENST00000544113

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACER3
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ACER3 (see all 43):
		hsa-let-7d hsa-miR-4328 hsa-miR-3653 hsa-miR-578 hsa-let-7g hsa-miR-649 hsa-let-7a hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: ACER3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ACER3

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		GenScript: all cDNA clones in your preferred vector: ACER3 (NM_018367)
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Additional mRNA sequence:

AF214454.1 AF327353.1 AK002100.1 AK090589.1 AK293800.1 AK294978.1 AK295142.1 AK295327.1

AK308856.1 AK315000.1 AK316120.1 BC049837.1 BC063034.1 BC073853.1

11 DOTS entries:

DT.215247 DT.95272209 DT.99965280 DT.75187136 DT.100775431 DT.120712876 DT.92430861 DT.91850107

DT.120712854 DT.91978817 DT.100775433

24/173 AceView cDNA sequences (see all 173):

AI375670 AA732220 AW971795 BQ023358 AI954517 BG056421 AA993809 AA258154

AW580728 BC049837 Z41426 AW269898 AI354655 Z42572 AA285133 BI824983

AI094877 BF109605 AA828500 BF367730 AL041534 CB151110 AU127447 AK090589

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ACER3 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15
SP1:			-								-
SP2:							-				-								-
SP3:			-				-				-								-
SP4:			-				-		-										-

ECgene alternative splicing isoforms for ACER3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACER3 expression in normal human tissues (normalized intensities) ACER3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGCAGAGC

About this image

ACER3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/4 selected tissues (see all 4) fully expand


Skin (Integumentary System) fully expand to see all 2 entries
skin

Blood (Cardiovascular System) fully expand to see all 2 entries
c-kit+ gr1+ mac1- myeloblasts

Limb (Muscoskeletal System)
Limb Muscle Progenitor Cells Forelimb Myotome

Skeletal Muscle (Muscoskeletal System)
Limb Muscle Progenitor Cells Forelimb Myotome

See ACER3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACER3

SOURCE GeneReport for Unigene cluster: Hs.23862

UniProtKB/Swiss-Prot: ACER3_HUMAN, Q9NUN7

Tissue specificity: Ubiquitously expressed. Highest expression in placenta

SABiosciences Custom PCR Arrays for ACER3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACER3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACER3 gene from 8/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Acer3^{1 , 5}	alkaline ceramidase 3^{1, 5}	88.51(n)¹ 88.39(a)¹		7 (53.65 cM)⁵ 66190¹ NM_025408.2¹ NP_079684.2¹ 98213658⁵
chicken (Gallus gallus)	Aves	ACER3¹	alkaline ceramidase 3	76.94(n) 74.44(a)		419087 XM_417279.3 XP_417279.1
lizard (Anolis carolinensis)	Reptilia	ACER3⁶	Uncharacterized protein	75(a)	1 ↔ 1	GL343493.1(138772-176417)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32071²	Xenopus laevis transcribed sequence with moderate similarity more	74.52(n)		CD303475.1
zebrafish (Danio rerio)	Actinopterygii	Dr.27687²	Transcribed sequence with weak similarity to protein more	77.72(n)		AI979378.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	YDC1(YPL087W)⁴ YDC1¹	Alkaline dihydroceramidase, involved in sphingolipid more⁴ Ydc1p¹	49.65(n)¹ 38.4(a)¹		16(383455-384408)⁴ 856018^{1, 4} NP_015238.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	ATCES1¹	dihydroceramidase	44.54(n) 29.83(a)		828328 NM_118359.3 NP_567660.1
rice (Oryza sativa)	Liliopsida	Os03g0698900¹	hypothetical protein	45.04(n) 32.64(a)		4333811 NM_001057518.1 NP_001050983.1

ENSEMBL Gene Tree for ACER3 (if available)
TreeFam Gene Tree for ACER3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12795242^1,2	C,F	--	76569933(+)	`gagggG/Agtact`	1	--	us2k¹		4		NA WA	242
rs117946672^1,2	F	--	76569952(+)	`ATTCCC/TGGAAG`	1	--	us2k¹		1		NA	120
rs144168028^1,2	C	--	76570007(+)	`TGGGCA/GACAGA`	1	--	us2k¹		0	--	--	--	--
rs193081866^1,2		--	76570030(+)	`CTCAAA/CAAAGA`	1	--	us2k¹		0	--	--	--	--
rs7931561^1,2	C,F,A,H	--	76570060(+)	`TATTCC/GTATTA`	1	--	us2k¹ tfbs³		28		NS EA NA WA CSA	2778
rs147781105^1,2	C	--	76570145(+)	`ATCACA/GAGGTC`	1	--	us2k¹		0	--	--	--	--
rs185412332^1,2		--	76570182(+)	`AAGGTA/GAAACC`	1	--	us2k¹		0	--	--	--	--
rs7931894^1,2	C,F,A	--	76570322(+)	`TGCCAC/GTGCAT`	1	--	us2k¹		7		NA WA CSA	12
rs189890384^1,2		--	76570339(+)	`CTGGCA/CGACAG`	1	--	us2k¹		0	--	--	--	--
rs10677160^1,2	C	--	76570372(+)	`aaaaa-/A/ AAAAAaaaaa`	1	--	us2k¹ trp³		1		NA	2

HapMap Linkage Disequilibrium report for ACER3 (76571911 - 76737841 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for ACER3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2661671	CNV	Deletion	23128226
esv1509546	CNV	Insertion	17803354
nsv507599	CNV	Insertion	20534489
nsv498761	CNV	Loss	21111241
nsv518920	CNV	Loss	19592680
esv23557	CNV	Loss	19812545
nsv396	CNV	Loss	18451855
nsv519309	CNV	Loss	19592680
nsv519700	CNV	Gain+Loss	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ACER3 for disorders About GeneDecksing

7 diseases for ACER3: About MalaCards

lipogranulomatosis farber lipogranulomatosis partial fetal alcohol syndrome cortical blindness

fetal alcohol syndrome blindness alcoholism

2 diseases from the University of Copenhagen DISEASES database for ACER3:

Partial fetal alcohol syndrome Farber lipogranulomatosis

Genetic Association Database (GAD): ACER3
Human Genome Epidemiology (HuGE) Navigator: ACER3 (5 documents)

Export disorders for ACER3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ACER3 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ACER3)

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Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. (PubMed id 11356846)^{1, 2, 3, 9} Mao C.... Obeid L.M. (2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)^{1, 4} Wheeler H.E....Kim S.K. (2009)
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. (PubMed id 18619555)^{1, 3} Mao C. and Obeid L.M. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cytoskeletal scaffolding proteins interact with Lynch- Syndrome associated mismatch repair protein MLH1. (PubMed id 20706999)¹ Brieger A....Trojan J. (2010)
Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. (PubMed id 20068046)¹ Hu W....Mao C. (2010)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55331	HGNC: 16066	AceView: PHCA	Ensembl:ENSG00000078124	euGenes: HUgn55331
ECgene: ACER3	Kegg: 55331	H-InvDB: ACER3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ACER3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACER3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACER3 gene:
Search GeneIP for patents involving ACER3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Alkaline Ceramidase 3

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Alkaline Ceramidase 3

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