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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACER1 Gene

protein-coding   GIFtS: 52
GCID: GC19M006261

Alkaline Ceramidase 1

(Previous name: N-acylsphingosine amidohydrolase (alkaline ceramidase) 3)
(Previous symbol: ASAH3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Alkaline Ceramidase 11 2     AlkCDase 12 3
ASAH31 2 3     N-Acylsphingosine Amidohydrolase 32 3
N-Acylsphingosine Amidohydrolase (Alkaline Ceramidase) 31 2     ALKCDase12
Acylsphingosine Deacylase 32 3     EC 3.5.1.233
Alkaline CDase 12 3     

External Ids:    HGNC: 183561   Entrez Gene: 1259812   Ensembl: ENSG000001677697   OMIM: 6134915   UniProtKB: Q8TDN73   

Export aliases for ACER1 gene to outside databases

Previous GC identifers: GC19M006259 GC19M006260 GC19M006065


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACER1 Gene:
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum
corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide
can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and
sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell
layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis
also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial
agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to
generate sphingosine (Houben et al., 2006 (PubMed 16477081); Sun et al., 2008 (PubMed 17713573)).(supplied by
OMIM, Jul 2010)

GeneCards Summary for ACER1 Gene: 
ACER1 (alkaline ceramidase 1) is a protein-coding gene. Diseases associated with ACER1 include lipogranulomatosis, and farber lipogranulomatosis, and among its related super-pathways are Sphingolipid metabolism and Metabolic pathways. GO annotations related to this gene include dihydroceramidase activity and ceramidase activity. An important paralog of this gene is ACER2.

UniProtKB/Swiss-Prot: ACER1_HUMAN, Q8TDN7
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a
highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but
not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the
levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)

summary for ACER1 Gene:
Ceramidases (EC 3.5.1.23) are a group of enzymes which catalyze the hydrolysis of ceramides to produce
sphingosine, which subsequently undergoes phosphorylation to generate sphingosine-1-phosphate (S1P).
Ceramide and its downstream products, sphingosine and S1P, are bioactive lipids that mediate various
cellular processes including cell growth arrest, differentiation and apoptosis.

Gene Wiki entry for ACER1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACER1 gene promoter:
         NF-AT4   NF-AT2   Lmo2   NF-AT3   Pax-4a   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACER1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACER1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ACER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACER1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006261:  view genomic region     (about GC identifiers)

Start:
6,306,153 bp from pter      End:
6,333,640 bp from pter
Size:
27,488 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACER1_HUMAN, Q8TDN7 (See protein sequence)
Recommended Name: Alkaline ceramidase 1  
Size: 264 amino acids; 31095 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Explore the universe of human proteins at neXtProt for ACER1: NX_Q8TDN7

Explore proteomics data for ACER1 at MOPED 

ACER1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ACER1 Protein Expression

REFSEQ proteins: NP_597999.1  
ENSEMBL proteins: 
 ENSP00000301452  
Reactome Protein details: Q8TDN7
Human Recombinant Protein Products for ACER1: 
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Cloud-Clone Corp. Proteins for ACER1 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA17713573
GO:0005789endoplasmic reticulum membrane TAS--
GO:0016021integral to membrane IEA--

ACER1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ACER: Alkaline ceramidase

1 InterPro protein domain:
 IPR008901 Ceramidase

Graphical View of Domain Structure for InterPro Entry Q8TDN7

ProtoNet protein and cluster: Q8TDN7

1 Blocks protein domain: IPB008901 Alkaline phytoceramidase

UniProtKB/Swiss-Prot: ACER1_HUMAN, Q8TDN7
Similarity: Belongs to the alkaline ceramidase family


ACER1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ACER1_HUMAN, Q8TDN7
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a
highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but
not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the
levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)
Catalytic activity: N-acylsphingosine + H(2)O = a carboxylate + sphingosine
Enzyme regulation: Inhibited by sphingosine (By similarity)

     Enzyme Number (IUBMB): EC 3.5.1.231

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
GO:0017040ceramidase activity IDA17713573
GO:0071633dihydroceramidase activity IDA--
     
ACER1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for ACER1 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACER1 
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miRNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ACER1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Sphingolipid metabolism
Sphingolipid metabolism0.63
Sphingolipid de novo biosynthesis0.47
Sphingolipid metabolism0.63
2Metabolism
Metabolism0.40
Metabolism of lipids and lipoproteins0.34
Metabolic pathways0.40
3sphingosine and sphingosine-1-phosphate metabolism
sphingosine and sphingosine-1-phosphate metabolism

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for ACER1
    sphingosine and sphingosine-1-phosphate metabolism

4        Reactome Pathways for ACER1
    Sphingolipid metabolism
Metabolism
Metabolism of lipids and lipoproteins
Sphingolipid de novo biosynthesis


2         Kegg Pathways  (Kegg details for ACER1):
    Sphingolipid metabolism
Metabolic pathways


ACER1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACER1

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/21 Interacting proteins for ACER1 (ENSP000003014524) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
InteractantInteraction Details
GeneCardExternal ID(s)
CERKENSP000002162644STRING: ENSP00000216264
DEGS1ENSP000003164764STRING: ENSP00000316476
DEGS2ENSP000003071264STRING: ENSP00000307126
ENPP7ENSP000003326564STRING: ENSP00000332656
GBAENSP000003145084STRING: ENSP00000314508
About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006665sphingolipid metabolic process TAS--
GO:0006672ceramide metabolic process ----
GO:0008544epidermis development IEP16477081
GO:0010446response to alkalinity IDA17713573
GO:0019216regulation of lipid metabolic process IEA--

ACER1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for ACER1 available from Tocris Bioscience    About this table
CompoundAction CAS #
Ceranib 1Ceramidase inhibitor; antiproliferative[328076-61-5]

10/120 HMDB Compounds for ACER1 (see all 120)    About this table
CompoundSynonyms CAS #PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
3-O-Sulfogalactosylceramide (d18:1/26:1(17Z))Sulfatide (d18:1/26:1(17Z)) (see all 13)928346-40-1--

Search CenterWatch for drugs/clinical trials and news about ACER1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACER1 gene: 
NM_133492.2  

Unigene Cluster for ACER1:

Alkaline ceramidase 1
Hs.352609  [show with all ESTs]
Unigene Representative Sequence: NM_133492
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000301452(uc002mel.2)
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Additional mRNA sequence: 

AF347024.1 BC112122.1 BC112124.1 

1 DOTS entry:

DT.91869736 

3 AceView cDNA sequences:

AF347024 NM_133492 BG698821 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACER1 expression in normal human tissues (normalized intensities)      ACER1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCTTGGTGG
ACER1 Expression
About this image


ACER1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Myoblasts Mandibular Arch Muscles

 -- (Integumentary System)
         skin   

See ACER1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACER1

SOURCE GeneReport for Unigene cluster: Hs.352609

UniProtKB/Swiss-Prot: ACER1_HUMAN, Q8TDN7
Tissue specificity: Mainly expressed in epidermis

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACER1 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Acer11 , 5 alkaline ceramidase 11, 5 80.93(n)1
79.55(a)1
  17 (29.59 cM)5
1711681  NM_175731.41  NP_783858.11 
 569534905 
chicken
(Gallus gallus)
Aves ACER11 alkaline ceramidase 1 60.46(n)
47.53(a)
  420088  XM_418208.3  XP_418208.2 
zebrafish
(Danio rerio)
Actinopterygii Dr.251182 Transcribed sequence with weak similarity to protein more 77.51(n)    BI887188.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDC16
YPC16
Alkaline dihydroceramidase, involved in sphingolip...
Alkaline ceramidase that also has reverse (CoA-ind...
17(a)
16(a)
many ↔ many
many ↔ many
XVI(383455-384408)
II(596115-597065)


ENSEMBL Gene Tree for ACER1 (if available)
TreeFam Gene Tree for ACER1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ACER1 gene
ACER22  
1 SIMAP similar gene for ACER1 using alignment to 1 protein entry:     ACER1_HUMAN:
ACER2

ACER1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/825 SNPs in ACER1 are shown (see all 825)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1381714861,2
C,Funtested16333510(+) GGAAGC/G/TTGCTC 2 N S mis12NA EU 4901
rs1919947581,2
--6306028(+) AGTGAC/GCACCA 1 -- ds50010--------
rs1426270551,2
C--6306096(+) TCTTGC/TTGCCC 1 -- ds50010--------
rs1509971681,2
--6306215(+) CACCAC/TGCCCG 1 -- ds50010--------
rs1838820911,2
--6306220(+) CGCCCA/GGCTAA 1 -- ds50010--------
rs1884746471,2
--6306260(+) TGCCAC/TGTTGG 1 -- ds50010--------
rs1930462651,2
--6306351(+) ACCGTG/TCCCAG 1 -- ds50010--------
rs1842853141,2
--6306385(+) CACATC/TCTTCA 1 -- ds50010--------
rs803018181,2
C,F--6306508(+) GATGCA/TCGAGA 1 -- ds50011Minor allele frequency- T:0.05NA 120
rs1871054761,2
--6306635(+) ACGAGA/TGTCCC 1 -- ut310--------

HapMap Linkage Disequilibrium report for ACER1 (6306153 - 6333640 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for ACER1:    About this table     
Variant IDTypeSubtypePubMed ID
esv2629784CNV Deletion19546169
nsv513511CNV Insertion21212237
nsv2397CNV Insertion18451855
nsv910916CNV Loss21882294
nsv2399CNV Loss18451855
nsv910911CNV Loss21882294
dgv3698n71CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 613491    OMIM disorders: --

2 diseases for ACER1:    About MalaCards
lipogranulomatosis    farber lipogranulomatosis

1 disease from the University of Copenhagen DISEASES database for ACER1:
Farber lipogranulomatosis

ACER1 for disorders           About GeneDecksing


Export disorders for ACER1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ACER1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACER1)
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  1. Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. (PubMed id 12783875)1, 2, 3 Mao C.... Obeid L.M. (2003)
  2. Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. (PubMed id 16477081)1, 2 Houben E.... Uchida Y. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. (PubMed id 17713573)1 Sun W....Mao C. (2008)
  5. Large-scale identification of human genes implicated in epidermal barrier function. (PubMed id 17562024)1 Toulza E.... Guerrin M. (2007)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. [Molecular evolution of neutral ceramidase: signalling molecule and virulence factor] (PubMed id 11915342)1 Ito M....Mori K. (2002)
  8. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. (PubMed id 18619555)9 Mao C. and Obeid L.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 125981 HGNC: 18356 AceView: ASAH3 Ensembl:ENSG00000167769 euGenes: HUgn125981
ECgene: ACER1 Kegg: 125981 H-InvDB: ACER1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ACER1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ACER1 gene:
Search GeneIP for patents involving ACER1

GeneCards and IP:
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