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ACER1 Gene

protein-coding   GIFtS: 51
GCID: GC19M006261

Alkaline Ceramidase 1

(Previous name: N-acylsphingosine amidohydrolase (alkaline ceramidase) 3)
(Previous symbol: ASAH3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alkaline Ceramidase 11 2     AlkCDase 12 3
ASAH31 2 3     N-Acylsphingosine Amidohydrolase 32 3
N-Acylsphingosine Amidohydrolase (Alkaline Ceramidase) 31 2     ALKCDase12
Acylsphingosine Deacylase 32 3     EC 3.5.1.233
Alkaline CDase 12 3     

External Ids:    HGNC: 183561   Entrez Gene: 1259812   Ensembl: ENSG000001677697   OMIM: 6134915   UniProtKB: Q8TDN73   

Export aliases for ACER1 gene to outside databases

Previous GC identifers: GC19M006259 GC19M006260 GC19M006065


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACER1 Gene:
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum
corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide
can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and
sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell
layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis
also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial
agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to
generate sphingosine (Houben et al., 2006 (PubMed 16477081); Sun et al., 2008 (PubMed 17713573)).(supplied by
OMIM, Jul 2010)

GeneCards Summary for ACER1 Gene:
ACER1 (alkaline ceramidase 1) is a protein-coding gene. Diseases associated with ACER1 include lipogranulomatosis, and farber lipogranulomatosis. GO annotations related to this gene include dihydroceramidase activity and ceramidase activity. An important paralog of this gene is ACER2.

UniProtKB/Swiss-Prot: ACER1_HUMAN, Q8TDN7
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a
highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but
not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the
levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)

summary for ACER1 Gene:
Ceramidases (EC 3.5.1.23) are a group of enzymes which catalyze the hydrolysis of ceramides to produce
sphingosine, which subsequently undergoes phosphorylation to generate sphingosine-1-phosphate (S1P).
Ceramide and its downstream products, sphingosine and S1P, are bioactive lipids that mediate various
cellular processes including cell growth arrest, differentiation and apoptosis.

Gene Wiki entry for ACER1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACER1 gene promoter:
         NF-AT4   NF-AT2   Lmo2   NF-AT3   Pax-4a   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACER1 promoter sequence
   Search Chromatin IP Primers for ACER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ACER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACER1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006261:  view genomic region     (about GC identifiers)

Start:
6,306,153 bp from pter      End:
6,333,640 bp from pter
Size:
27,488 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ACER1_HUMAN, Q8TDN7 (See protein sequence)
Recommended Name: Alkaline ceramidase 1  
Size: 264 amino acids; 31095 Da

Explore the universe of human proteins at neXtProt for ACER1: NX_Q8TDN7

Explore proteomics data for ACER1 at MOPED


See ACER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_597999.1  
ENSEMBL proteins: 
 ENSP00000301452  
Reactome Protein details: Q8TDN7

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ACER: Alkaline ceramidase

1 InterPro protein domain:
 IPR008901 Ceramidase

Graphical View of Domain Structure for InterPro Entry Q8TDN7

ProtoNet protein and cluster: Q8TDN7

1 Blocks protein domain: IPB008901 Alkaline phytoceramidase

UniProtKB/Swiss-Prot: ACER1_HUMAN, Q8TDN7
Similarity: Belongs to the alkaline ceramidase family


ACER1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ACER1_HUMAN, Q8TDN7
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a
highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but
not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the
levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)
Catalytic activity: N-acylsphingosine + H(2)O = a carboxylate + sphingosine
Enzyme regulation: Inhibited by sphingosine (By similarity)

     Enzyme Number (IUBMB): EC 3.5.1.231

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
GO:0017040ceramidase activity IDA17713573
GO:0071633dihydroceramidase activity IDA--
     
ACER1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACER1
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ACER1_HUMAN, Q8TDN7: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA17713573
GO:0005789endoplasmic reticulum membrane TAS--
GO:0016021integral component of membrane IEA--

ACER1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ACER1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Sphingolipid metabolism
Sphingolipid metabolism0.61
Sphingolipid de novo biosynthesis0.46
Sphingolipid metabolism0.61
2Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
3sphingosine and sphingosine-1-phosphate metabolism
sphingosine and sphingosine-1-phosphate metabolism

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for ACER1
    sphingosine and sphingosine-1-phosphate metabolism

1 Reactome Pathway for ACER1
    Sphingolipid de novo biosynthesis


2 Kegg Pathways  (Kegg details for ACER1):
    Sphingolipid metabolism
Metabolic pathways


ACER1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACER1
Interactions:

    Search GeneGlobe Interaction Network for ACER1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ACER1 (ENSP000003014524) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
CERKENSP000002162644STRING: ENSP00000216264
DEGS1ENSP000003164764STRING: ENSP00000316476
DEGS2ENSP000003071264STRING: ENSP00000307126
ENPP7ENSP000003326564STRING: ENSP00000332656
GBAENSP000003145084STRING: ENSP00000314508
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Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006665sphingolipid metabolic process TAS--
GO:0006672ceramide metabolic process ----
GO:0008544epidermis development IEP16477081
GO:0010446response to alkalinity IDA17713573
GO:0019216regulation of lipid metabolic process IEA--

ACER1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for ACER1 available from Tocris Bioscience    About this table
CompoundAction CAS #
Ceranib 1Ceramidase inhibitor; antiproliferative[328076-61-5]

Selected HMDB Compounds for ACER1 (see all 120)    About this table
CompoundSynonyms CAS #PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
3-O-Sulfogalactosylceramide (d18:1/26:1(17Z))Sulfatide (d18:1/26:1(17Z)) (see all 13)928346-40-1--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ACER1 gene: 
NM_133492.2  

Unigene Cluster for ACER1:

Alkaline ceramidase 1
Hs.352609  [show with all ESTs]
Unigene Representative Sequence: NM_133492
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000301452(uc002mel.2)
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  QuantiFast Probe-based Assays in human, mouse, rat ACER1

Additional mRNA sequence: 

AF347024.1 BC112122.1 BC112124.1 

1 DOTS entry:

DT.91869736 

3 AceView cDNA sequences:

NM_133492 AF347024 BG698821 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ACER1 expression in normal human tissues (normalized intensities)      ACER1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCTTGGTGG
ACER1 Expression
About this image


ACER1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Myoblasts Mandibular Arch Muscles
ACER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ACER1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.352609

UniProtKB/Swiss-Prot: ACER1_HUMAN, Q8TDN7
Tissue specificity: Mainly expressed in epidermis

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ACER1 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Acer11 , 5 alkaline ceramidase 11, 5 80.93(n)1
79.55(a)1
  17 (29.59 cM)5
1711681  NM_175731.41  NP_783858.11 
 569534905 
chicken
(Gallus gallus)
Aves ACER11 alkaline ceramidase 1 60.46(n)
47.53(a)
  420088  XM_004948752.1  XP_004948809.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia acer11 alkaline ceramidase 1 60.31(n)
58.4(a)
  100127603  NM_001112961.1  NP_001106432.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.251182 Transcribed sequence with weak similarity to protein more 77.51(n)    BI887188.1 
fruit fly
(Drosophila melanogaster)
Insecta bwa6
brain washing
33(a)
1 → many
2L(20066370-20073719)
worm
(Caenorhabditis elegans)
Secernentea W02F12.26
Protein W02F12.2 (W02F12.2) mRNA, complete cds
25(a)
1 → many
V(6695216-6697652) WBGene00020947


ENSEMBL Gene Tree for ACER1 (if available)
TreeFam Gene Tree for ACER1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ACER1 gene
ACER22  
1 SIMAP similar gene for ACER1 using alignment to 1 protein entry:     ACER1_HUMAN:
ACER2

ACER1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ACER1 (see all 825)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1381714861,2
C,Funtested16333510(+) GGAAGC/G/TTGCTC 2 N S mis12NA EU 4901
rs1919947581,2
--6306028(+) AGTGAC/GCACCA 1 -- ds50010--------
rs1426270551,2
C--6306096(+) TCTTGC/TTGCCC 1 -- ds50010--------
rs1509971681,2
--6306215(+) CACCAC/TGCCCG 1 -- ds50010--------
rs1838820911,2
--6306220(+) CGCCCA/GGCTAA 1 -- ds50010--------
rs1884746471,2
--6306260(+) TGCCAC/TGTTGG 1 -- ds50010--------
rs1930462651,2
--6306351(+) ACCGTG/TCCCAG 1 -- ds50010--------
rs1842853141,2
--6306385(+) CACATC/TCTTCA 1 -- ds50010--------
rs803018181,2
C,F--6306508(+) GATGCA/TCGAGA 1 -- ds50011Minor allele frequency- T:0.05NA 120
rs1871054761,2
--6306635(+) ACGAGA/TGTCCC 1 -- ut310--------

HapMap Linkage Disequilibrium report for ACER1 (6306153 - 6333640 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for ACER1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2629784CNV Deletion19546169
nsv513511CNV Insertion21212237
nsv2397CNV Insertion18451855
nsv910916CNV Loss21882294
nsv2399CNV Loss18451855
nsv910911CNV Loss21882294
dgv3698n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ACER1
DNA2.0 Custom Variant and Variant Library Synthesis for ACER1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613491    OMIM disorders: --

2 diseases for ACER1:    About MalaCards
lipogranulomatosis    farber lipogranulomatosis

1 disease from the University of Copenhagen DISEASES database for ACER1:
Farber lipogranulomatosis

ACER1 for disorders           About GeneDecksing


Export disorders for ACER1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ACER1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ACER1)
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  1. Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. (PubMed id 12783875)1, 2, 3 Mao C.... Obeid L.M. (J. Biol. Chem. 2003)
  2. Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. (PubMed id 16477081)1, 2 Houben E.... Uchida Y. (J. Lipid Res. 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. (PubMed id 17713573)1 Sun W....Mao C. (J. Invest. Dermatol. 2008)
  5. Large-scale identification of human genes implicated in epidermal barrier function. (PubMed id 17562024)1 Toulza E.... Guerrin M. (Genome Biol. 2007)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. [Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]. (PubMed id 11915342)1 Ito M....Mori K. (Tanpakushitsu Kakusan Koso 2002)
  8. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. (PubMed id 18619555)9 Mao C. and Obeid L.M. (Biochim. Biophys. Acta 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 125981 HGNC: 18356 AceView: ASAH3 Ensembl:ENSG00000167769 euGenes: HUgn125981
ECgene: ACER1 Kegg: 125981 H-InvDB: ACER1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ACER1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ACER1 gene:
Search GeneIP for patents involving ACER1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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