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ACE2 Gene

protein-coding   GIFtS: 69

GC0XM015489
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ACEH 2, 3, 5
DKFZp434A014 2
EC 3.4.17.- 3
OTTHUMP00000022963 2
Descriptions
ACE-related carboxypeptidase 2, 3
Angiotensin-converting enzyme homolog 3
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 2
angiotensin I converting enzyme 2 2
angiotensin converting enzyme-like protein 2
External Ids
HGNC: 135571
Entrez Gene: 592722
UniProtKB: Q9BYF13
Ensembl: ENSG000001302347
Search outside databases for aliases for ACE2 gene

Previous GC identifers: GC0XM015289 GC0XM014404 GC0XM014781 GC0XM014940 GC0XM015338

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACE2:
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl
carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This
secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II
into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene
suggests that it may play a role in the regulation of cardiovascular and renal function, as well
as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein
of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1
Function: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown
function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13
and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of
human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike
glycoprotein of both coronaviruses

Gene Wiki entry for ACE2 (Angiotensin-converting_enzyme_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ACE2 gene  

Entrez Gene cytogenetic band: Xp22   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22

ACE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM015489:     (about GC identifiers)

Start:
15,489,077 bp from pter
End:
15,529,123 bp from pter
Size:
40,047 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011757.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1 (See protein sequence)
Recommended Name: Angiotensin-converting enzyme 2 precursor  
Size: 805 amino acids; 92463 Da
Cofactor: Binds 1 zinc ion per subunit
Cofactor: Binds 1 chloride ion per subunit
Subunit: Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein
Subcellular location: Processed angiotensin-converting enzyme 2: Secreted
Subcellular location: Cell membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :
1R42 (3D)    1R4L (3D)    1XJP (3D)    2AJF (3D)    3D0G (3D)    3D0H (3D)    3D0I (3D)    
Secondary accessions: Q6UWP0 Q86WT0 Q9NRA7 Q9UFZ6
Alternative splicing: 2 isoforms:  Q9BYF1-1   Q9BYF1-2   

Post-translational modifications:

  • N-glycosylation on Asn-90 may limit SARS infectivity1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_068576.1  

    ENSEMBL proteins: 
    ENSP00000252519 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich CompoZr ZFN for ACE2  
    R&D Systems Recombinant & Natural Proteins for ACE2 (ACE-2)
    Enzo Life Sciences proteins for ACE2
    Recombinant Proteins from Abcam (Angiotensin Converting Enzyme 2)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IDA10969042
    GO:0005615 extracellular space IDA18258853
    GO:0005634 nucleus IDA18029348
    GO:0005886 plasma membrane IEA--
    GO:0009986 cell surface IDA18343844
    About this table

    Antibodies for ACE2: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of ACE2
    Sigma-Aldrich Antibodies for ACE2
    R&D Systems Antibodies for ACE2 (ACE-2)
    Antibodies from Abcam (Angiotensin Converting Enzyme 2), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for ACE2

    Assays for ACE2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR001548 Peptidase_M2
     IPR006025 Pept_M_Zn_BS


       GeneDecks  ACE2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BYF1

    ProtoNet protein and cluster: Q9BYF1

    1 Blocks protein family: IPB001548 Peptidyl-dipeptidase A (M2) metalloprotease family signature

    UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1
    Similarity: Belongs to the peptidase M2 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACE2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACE2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021804

                  Applied Biosystems Silencer® siRNAs for ACE2

                  Sigma-Aldrich siRNA and siRNA Panels for ACE2  
                         Sigma-Aldrich shRNA for ACE2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021804
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021804
                                     untagged cDNA clone in CMV expression vector: NM_021804 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_021804

    UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1
    Function: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown
    function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13
    and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of
    human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike
    glycoprotein of both coronaviruses
    Enzyme regulation: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760,
    cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat
    Biophysicochemical properties: Kinetic parameters: KM=6.9 uM for angiotensin I; KM=2 uM for
    angiotensin II; KM=6.8 uM for apelin-13; KM=5.5 uM for dynorphin-13; pH dependence: Optimum pH is
    6.5 in the presence of 1 M NaCl. Active from pH 6 to 9;
    Induction: Up-regulated in failing heart
    Enzyme Number (IUBMB): EC 3.4.17.- 

    7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ace2):

    cellularhomeostasis/metabolismlife span-post-weaning/agingmuscle
    renal/urinary systemrespiratory system

    5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618 viral receptor activity IDA18343844
    GO:0001948 glycoprotein binding IPI18343844
    GO:0004180 carboxypeptidase activity IDA10969042
    GO:0008233 peptidase activity IEA--
    GO:0008237NOT metallopeptidase activity IDA10924499
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for ACE2
     Selected targets of HNF1
     Selected targets of C/EBPalpha

       GeneDecks  ACE2 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for ACE2):
     hsa04614 Renin-angiotensin system

       GeneDecks  ACE2 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ACE2 


    5/18 Interacting proteins for ACE2 (ENSP000002525193 Q9BYF12) via UniProtKB, MINT, and/or STRING (see all 18 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621582MINT-6175484
    CALM2P621582MINT-6175484
    CALM3P621582MINT-6175484
    SLC6A19ENSP000003053023STRING (score=.968)
    AGTENSP000003556273STRING (score=.962)
    About this table

    5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001817 regulation of cytokine production IC15380922
    GO:0002005 angiotensin catabolic process in blood IC10924499
    GO:0003051 angiotensin-mediated drinking behavior IMP18258853
    GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IMP18258853
    GO:0006508 proteolysis IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for ACE2
    Browse Small Molecules at Sigma-Aldrich

    Compounds for ACE2 available from Tocris Bioscience
    9 Novoseek chemical compound relationships for ACE2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 29.35 10 12025971 (2), 12358520 (1), 15165741 (1), 18324760 (1) (see all 7)
    oxygen 5.63 3 18660448 (2)
    nadph 4.10 3 16046899 (1), 16179584 (1)
    glyceraldehyde 3-phosphate 2.57 3 17303661 (1), 17260463 (1)
    chloride 1.30 21 19021774 (5), 14609329 (4), 16008552 (2)
    superoxide 0.00 1 2159692 (1)
    nitric oxide 0.00 15 17906677 (2), 16574921 (1), 16962475 (1), 17345786 (1) (see all 5)
    cholesterol 0.00 5 18814896 (2), 18279660 (1), 17000927 (1)
    leucine 0.00 2 17095582 (1), 10969042 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACE2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACE2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021804

                  Sigma-Aldrich siRNA and siRNA Panels for ACE2  
                         Sigma-Aldrich shRNA for ACE2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_021804  

    REFSEQ mRNAs for ACE2 gene: 

    NM_021804.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_021804  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021804
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021804
                                     untagged cDNA clone in CMV expression vector: NM_021804 

    Additional cDNA sequence: 

    AB046569.1 AB193259.1 AB193260.1 AF241254.1 AF291820.1 AK026461.1 AK315144.1 AL110224.1 
    AY623811.1 BC032938.1 BC039902.1 BC048094.1 BC048144.1 BC059378.1 CR599955.1 

    6 DOTS entries:

    DT.307623  DT.101981334  DT.121278420  DT.95307906  DT.121278416  DT.65286672 

    24/47 AceView cDNA sequences (see all 47 ):

    AY623811 NM_021804 AF291820 BC059378 AI928360 BC048094 AW611816 AF241254 
    AL110224 BC039902 AL551235 AA421125 BX097232 CR599955 BX484152 BP371391 
    BC048144 AK026461 AL574873 AI831883 AA397955 AW271467 BG401683 AI628611 

    highest scoring ESTs for ACE2:

    AB046569 AF241254 AF291820 BC032938 BC039902 BC048094 BC048144 BC059378 BG722079 BI561069 

    Unigene Cluster for ACE2:

    Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
    Hs.178098  [show with all ESTs]
    Unigene Representative Sequence: AB193259


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ACE2 (see all 6 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                      -                     
    SP3:              -     -                                                                                                                                       
    SP4:                                                                                                              -     -                                       
    SP5:                                                                                                                                                            

    ExUns: 17b ^ 18 ^ 19 ^ 20
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        

    About this scheme

    ECgene alternative splicing isoforms for ACE2

    1 Ensembl transcript including schematic representation:
    ENST00000252519  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ACE2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ACE2

    1 / 2 / 3

    5 probe-sets matching ACE2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    51620_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI628611 0.60 1.00 0.82 1

    222257_s_at2, 3 U133-A 1 1.00 1.00 -- -- AK026461 0.60 1.00 0.82 1

    219962_at2, 3 U133-A 1 1.00 1.00 -- -- NM_021804 0.60 1.00 0.82 1

    222257_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    219962_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ACE2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCAAGGAGA

    SOURCE GeneReport for Unigene cluster: Hs.178098

    UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1
    Tissue specificity: Expressed in endothelial cells from small and large arteries, and in arterial
    smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small
    intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis,
    and gastrointestinal system

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ACE2 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ACE21   -- angiotensin I converting enzyme (peptidyl-dipeptidase more 87.23(n)
    84.2(a)
    480847  XM_537964.2  XP_537964.2 
    rat
    (Rattus norvegicus)
    Ace21   -- angiotensin I converting enzyme (peptidyl-dipeptidase more 85.05(n)
    82.48(a)
    302668  NM_001012006.1  NP_001012006.1 
    mouse
    (Mus musculus)
    Ace21, 5 X (70.50 cM)5
    angiotensin I converting enzyme (peptidyl-dipeptidase more1, 5 85.22(n)1
    82.11(a)1
    700081  NM_027286.31  NP_081562.21 
     AB0531815  AB0531825  (see all 15)
    chicken
    (Gallus gallus)
    ACE21   -- angiotensin I converting enzyme (peptidyl-dipeptidase more 68.51(n)
    67.04(a)
    418623  XM_416822.2  XP_416822.2 
    zebrafish
    (Danio rerio)
    BC053284.12   --   -- 72.89(n)  BC053284.1 
    About this table        Species with no ortholog for ACE2

    ENSEMBL Gene Tree for ACE2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ACE2 gene
    ACE2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/197 NCBI SNPs in ACE2 are shown (see all 197 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 91)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs46461141,2
    C,F,H15529303(-) TTTCCG/ATGTAT 1 -- ng317Minor allele frequency- A:0.03NS EU EA WA 576
    rs46461151,2
    C,F,H15529190(-) TTCTTA/GTTTGA 1 -- ng318Minor allele frequency- G:0.01NS EU EA WA 671
    rs46461131,2
    C,F,H15529379(-) AAAACC/TATACA 1 -- ng317Minor allele frequency- T:0.03NS EU EA WA 576
    rs46461161,2
    C,F,H15528879(-) GGCCAA/GGACAT 1 K/R mis114Minor allele frequency- G:0.01NS EU EA WA NA 1035
    --
    rs46461121,2
    C,F15529654(-) TACTCG/AGGAGG 1 -- ng313Minor allele frequency- A:0.07NS 159
    --
    rs117981041,2
    H15503775(+) CACCTC/ACACTT 1 C/W mis1 ese34Minor allele frequency- A:0.00EU EA WA 406
    rs46461791,2
    C,F,H15494341(-) AAAAAT/CGTGTC 1 N/N syn1 ese315Minor allele frequency- C:0.03NS EU EA WA NA 2263
    rs358033181,2
    C,F15492130(+) CCCATC/TACAAC 1 V/V syn11Minor allele frequency- T:0.03NA 78
    --
    rs19781241,2
    A,C,F,H,O15527984(+) TGGACC/TTCTCC 1 -- int116Minor allele frequency- T:0.21EU EA WA NS NA 1247
    --
    rs15142791,2
    A,C,F,H,O15514786(+) ATGCTA/GTATCT 1 -- int118Minor allele frequency- G:0.18NA EA NS EU WA 1104
    About this table

    HapMap Linkage Disequilibrium images for ACE2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300335

    10/22 Novoseek disease relationships for ACE2 gene (see all 22 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    coronavirus infections 74.46 3 16581295 (1), 17974127 (1), 19297479 (1)
    diabetic nephropathies 41.44 19 16211375 (4), 18389211 (3), 19034303 (2), 12623933 (2) (see all 6)
    renal disease 36.11 22 15538735 (5), 19034303 (4), 18367030 (2), 18371537 (2) (see all 10)
    vesicular stomatitis 32.86 1 16690935 (1)
    essential hypertension 32.59 18 16866021 (3), 16215952 (2), 17024138 (1), 15477383 (1) (see all 6)
    cardiovascular diseases 28.19 11 16009403 (2), 17703127 (2), 18258853 (1), 16822235 (1) (see all 5)
    cardiomyopathy 25.45 4 17499227 (3), 15151696 (1)
    heart failure 22.69 9 15151696 (3), 18718423 (2), 17499227 (2), 16962475 (1) (see all 5)
    virus infection 19.22 4 15221932 (1), 18490652 (1), 15496474 (1), 16510163 (1)
    intracranial aneurysm 9.80 1 16574921 (1)
    About this table

    Genetic Association Database: ACE2
    Human Genome Epidemiology Navigator: ACE2 (18 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/205 PubMed articles for ACE2 gene (see all 205 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 59272 HGNC: 13557 AceView: ACE2 Ensembl:ENSG00000130234 euGenes: HUgn59272
    ECgene: ACE2 H-InvDB: ACE2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ACE2 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ace2/
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



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