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ACE2 Gene

protein-coding GIFtS: 69

GC0XM015489

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACEH ^², ³, ⁵
DKFZp434A014 ^²
EC 3.4.17.- ^³
OTTHUMP00000022963 ^²

Descriptions
ACE-related carboxypeptidase ^², ³
Angiotensin-converting enzyme homolog ^³
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 ^²
angiotensin I converting enzyme 2 ^²
angiotensin converting enzyme-like protein ^²

External Ids
HGNC: 13557¹
Entrez Gene: 59272²
UniProtKB: Q9BYF1³
Ensembl: ENSG00000130234⁷

Search outside databases for aliases for ACE2 gene

Previous GC identifers: GC0XM015289 GC0XM014404 GC0XM014781 GC0XM014940 GC0XM015338

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACE2:

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl

carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This

secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II

into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene

suggests that it may play a role in the regulation of cardiovascular and renal function, as well

as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein

of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1

Function: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown

function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13

and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of

human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike

glycoprotein of both coronaviruses

Gene Wiki entry for ACE2 (Angiotensin-converting_enzyme_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACE2 gene

Entrez Gene cytogenetic band: Xp22 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22

ACE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM015489: (about GC identifiers)

Start:	15,489,077 bp from pter
End:	15,529,123 bp from pter
Size:	40,047 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011757.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1 (See protein sequence)

Recommended Name: Angiotensin-converting enzyme 2 precursor

Size: 805 amino acids; 92463 Da

Cofactor: Binds 1 zinc ion per subunit

Cofactor: Binds 1 chloride ion per subunit

Subunit: Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein

Subcellular location: Processed angiotensin-converting enzyme 2: Secreted

Subcellular location: Cell membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1R42 (3D)

1R4L (3D)

1XJP (3D)

2AJF (3D)

3D0G (3D)

3D0H (3D)

3D0I (3D)

Secondary accessions: Q6UWP0 Q86WT0 Q9NRA7 Q9UFZ6

Alternative splicing: 2 isoforms: Q9BYF1-1 Q9BYF1-2

Post-translational modifications:

N-glycosylation on Asn-90 may limit SARS infectivity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_068576.1

ENSEMBL proteins:

ENSP00000252519

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for ACE2
	R&D Systems Recombinant & Natural Proteins for ACE2 (ACE-2)
	Enzo Life Sciences proteins for ACE2
	Recombinant Proteins from Abcam (Angiotensin Converting Enzyme 2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IDA	10969042
GO:0005615	extracellular space	IDA	18258853
GO:0005634	nucleus	IDA	18029348
GO:0005886	plasma membrane	IEA	--
GO:0009986	cell surface	IDA	18343844

About this table

Antibodies for ACE2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ACE2
	Sigma-Aldrich Antibodies for ACE2
	R&D Systems Antibodies for ACE2 (ACE-2)
	Antibodies from Abcam (Angiotensin Converting Enzyme 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ACE2

Assays for ACE2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BYF1

ProtoNet protein and cluster: Q9BYF1

1 Blocks protein family: IPB001548 Peptidyl-dipeptidase A (M2) metalloprotease family signature

UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1

Similarity: Belongs to the peptidase M2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACE2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACE2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021804

Applied Biosystems Silencer® siRNAs for ACE2

Sigma-Aldrich siRNA and siRNA Panels for ACE2

Sigma-Aldrich shRNA for ACE2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021804
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021804
untagged cDNA clone in CMV expression vector: NM_021804

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021804

UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1

Function: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown

function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13

and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of

human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike

glycoprotein of both coronaviruses

Enzyme regulation: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760,

cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat

Biophysicochemical properties: Kinetic parameters: KM=6.9 uM for angiotensin I; KM=2 uM for

angiotensin II; KM=6.8 uM for apelin-13; KM=5.5 uM for dynorphin-13; pH dependence: Optimum pH is

6.5 in the presence of 1 M NaCl. Active from pH 6 to 9;

Induction: Up-regulated in failing heart

Enzyme Number (IUBMB): EC 3.4.17.-

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ace2):

	cellular	homeostasis/metabolism	life span-post-weaning/aging	muscle
renal/urinary system	respiratory system

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001618	viral receptor activity	IDA	18343844
GO:0001948	glycoprotein binding	IPI	18343844
GO:0004180	carboxypeptidase activity	IDA	10969042
GO:0008233	peptidase activity	IEA	--
GO:0008237	NOT metallopeptidase activity	IDA	10924499

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ACE2

5/18 Interacting proteins for ACE2 (ENSP00000252519³ Q9BYF1²) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM1	P62158²	MINT-6175484
CALM2	P62158²	MINT-6175484
CALM3	P62158²	MINT-6175484
SLC6A19	ENSP00000305302³	STRING (score=.968)
AGT	ENSP00000355627³	STRING (score=.962)

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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001817	regulation of cytokine production	IC	15380922
GO:0002005	angiotensin catabolic process in blood	IC	10924499
GO:0003051	angiotensin-mediated drinking behavior	IMP	18258853
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	IMP	18258853
GO:0006508	proteolysis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ACE2

Browse Small Molecules at Sigma-Aldrich

Compounds for ACE2 available from Tocris Bioscience
9 Novoseek chemical compound relationships for ACE2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	29.35	10	12025971 (2), 12358520 (1), 15165741 (1), 18324760 (1) (see all 7)
oxygen	5.63	3	18660448 (2)
nadph	4.10	3	16046899 (1), 16179584 (1)
glyceraldehyde 3-phosphate	2.57	3	17303661 (1), 17260463 (1)
chloride	1.30	21	19021774 (5), 14609329 (4), 16008552 (2)
superoxide	0.00	1	2159692 (1)
nitric oxide	0.00	15	17906677 (2), 16574921 (1), 16962475 (1), 17345786 (1) (see all 5)
cholesterol	0.00	5	18814896 (2), 18279660 (1), 17000927 (1)
leucine	0.00	2	17095582 (1), 10969042 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACE2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACE2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021804

Sigma-Aldrich siRNA and siRNA Panels for ACE2

Sigma-Aldrich shRNA for ACE2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021804

REFSEQ mRNAs for ACE2 gene:

NM_021804.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021804

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021804
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021804
                                 untagged cDNA clone in CMV expression vector: NM_021804

Additional cDNA sequence:

AB046569.1 AB193259.1 AB193260.1 AF241254.1 AF291820.1 AK026461.1 AK315144.1 AL110224.1

AY623811.1 BC032938.1 BC039902.1 BC048094.1 BC048144.1 BC059378.1 CR599955.1

6 DOTS entries:

DT.307623 DT.101981334 DT.121278420 DT.95307906 DT.121278416 DT.65286672

24/47 AceView cDNA sequences (see all 47 ):

AY623811 NM_021804 AF291820 BC059378 AI928360 BC048094 AW611816 AF241254

AL110224 BC039902 AL551235 AA421125 BX097232 CR599955 BX484152 BP371391

BC048144 AK026461 AL574873 AI831883 AA397955 AW271467 BG401683 AI628611

highest scoring ESTs for ACE2:

AB046569 AF241254 AF291820 BC032938 BC039902 BC048094 BC048144 BC059378 BG722079 BI561069

Unigene Cluster for ACE2:

Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Hs.178098 [show with all ESTs]

Unigene Representative Sequence: AB193259

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ACE2 (see all 6 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17a	·
SP1:
SP2:																																													-
SP3:					-		-
SP4:																																					-		-
SP5:

ExUns:	17b	^	18	^	19	^	20
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ACE2

1 Ensembl transcript including schematic representation:

ENST00000252519

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACE2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACE2

¹ / ² / ³

5 probe-sets matching ACE2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
51620_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AI628611	0.60	1.00	0.82	1
222257_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK026461	0.60	1.00	0.82	1
219962_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021804	0.60	1.00	0.82	1
222257_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219962_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACE2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCAAGGAGA

SOURCE GeneReport for Unigene cluster: Hs.178098
UniProtKB/Swiss-Prot: ACE2_HUMAN, Q9BYF1
Tissue specificity: Expressed in endothelial cells from small and large arteries, and in arterial
smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small
intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis,
and gastrointestinal system

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACE2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACE2¹	--	angiotensin I converting enzyme (peptidyl-dipeptidase more	87.23(n) 84.2(a)	480847 XM_537964.2 XP_537964.2
rat (Rattus norvegicus)	Ace2¹	--	angiotensin I converting enzyme (peptidyl-dipeptidase more	85.05(n) 82.48(a)	302668 NM_001012006.1 NP_001012006.1
mouse (Mus musculus)	Ace2^{1, 5}	X (70.50 cM)⁵	angiotensin I converting enzyme (peptidyl-dipeptidase more^{1, 5}	85.22(n)¹ 82.11(a)¹	70008¹ NM_027286.3¹ NP_081562.2¹ AB053181⁵ AB053182⁵ (see all 15)
chicken (Gallus gallus)	ACE2¹	--	angiotensin I converting enzyme (peptidyl-dipeptidase more	68.51(n) 67.04(a)	418623 XM_416822.2 XP_416822.2
zebrafish (Danio rerio)	BC053284.1²	--	--	72.89(n)	BC053284.1

About this table Species with no ortholog for ACE2

ENSEMBL Gene Tree for ACE2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACE2 gene

ACE²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/197 NCBI SNPs in ACE2 are shown (see all 197 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 91)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4646114^1,2	C,F,H	15529303(-)	`TTTCCG/ATGTAT`	1	--	ng3¹		7	NS EU EA WA	576
	rs4646115^1,2	C,F,H	15529190(-)	`TTCTTA/GTTTGA`	1	--	ng3¹		8	NS EU EA WA	671
	rs4646113^1,2	C,F,H	15529379(-)	`AAAACC/TATACA`	1	--	ng3¹		7	NS EU EA WA	576
	rs4646116^1,2	C,F,H	15528879(-)	`GGCCAA/GGACAT`	1	K/R	mis¹		14	NS EU EA WA NA	1035
--	rs4646112^1,2	C,F	15529654(-)	`TACTCG/AGGAGG`	1	--	ng3¹		3	NS	159
--	rs11798104^1,2	H	15503775(+)	`CACCTC/ACACTT`	1	C/W	mis¹ ese³		4	EU EA WA	406
	rs4646179^1,2	C,F,H	15494341(-)	`AAAAAT/CGTGTC`	1	N/N	syn¹ ese³		15	NS EU EA WA NA	2263
	rs35803318^1,2	C,F	15492130(+)	`CCCATC/TACAAC`	1	V/V	syn¹		1	NA	78
--	rs1978124^1,2	A,C,F,H,O	15527984(+)	`TGGACC/TTCTCC`	1	--	int¹		16	EU EA WA NS NA	1247
--	rs1514279^1,2	A,C,F,H,O	15514786(+)	`ATGCTA/GTATCT`	1	--	int¹		18	NA EA NS EU WA	1104

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HapMap Linkage Disequilibrium images for ACE2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300335

10/22 Novoseek disease relationships for ACE2 gene (see all 22 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
coronavirus infections	74.46	3	16581295 (1), 17974127 (1), 19297479 (1)
diabetic nephropathies	41.44	19	16211375 (4), 18389211 (3), 19034303 (2), 12623933 (2) (see all 6)
renal disease	36.11	22	15538735 (5), 19034303 (4), 18367030 (2), 18371537 (2) (see all 10)
vesicular stomatitis	32.86	1	16690935 (1)
essential hypertension	32.59	18	16866021 (3), 16215952 (2), 17024138 (1), 15477383 (1) (see all 6)
cardiovascular diseases	28.19	11	16009403 (2), 17703127 (2), 18258853 (1), 16822235 (1) (see all 5)
cardiomyopathy	25.45	4	17499227 (3), 15151696 (1)
heart failure	22.69	9	15151696 (3), 18718423 (2), 17499227 (2), 16962475 (1) (see all 5)
virus infection	19.22	4	15221932 (1), 18490652 (1), 15496474 (1), 16510163 (1)
intracranial aneurysm	9.80	1	16574921 (1)

About this table

Genetic Association Database: ACE2
Human Genome Epidemiology Navigator: ACE2 (18 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/205 PubMed articles for ACE2 gene (see all 205 ):

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. (PubMed id 10969042)^{1, 2, 3, 4} Donoghue M.... Acton S. (2000)
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome- coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). (PubMed id 15983030)^{1, 3, 4} Lambert D.W.... Turner A.J. (2005)
Myocardial infarction increases ACE2 expression in rat and humans. (PubMed id 15671045)^{1, 3, 4} Burrell L.M....Johnston C.I. (2005)
ACE2 gene expression is up-regulated in the human failing heart. (PubMed id 15151696)^{1, 3, 4} Goulter A.B.... Clark K.L. (2004)
Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2. (PubMed id 15452268)^{1, 3, 4} Li W.... Choe H. (2004)
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. (PubMed id 15141377)^{1, 3, 4} Hamming I....van Goor H. (2004)
Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy. (PubMed id 16283142)^{1, 3, 6} Lieb W....Erdmann J. (2006)
Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy. (PubMed id 16211375)^{1, 3, 6} Frojdo S....Groop P.H. (2005)
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. (PubMed id 15791205)^{1, 3, 4} Li W.... Farzan M. (2005)
The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. (PubMed id 15231706)^{1, 3, 4} Douglas G.C.... Lew R.A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 59272	HGNC: 13557	AceView: ACE2	Ensembl:ENSG00000130234	euGenes: HUgn59272
ECgene: ACE2	H-InvDB: ACE2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ACE2	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/ace2/

Licensable Technologies for ACE2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ACE2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACE2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACE2		Antibodies for ACE2
	Explore super-pooled esiRNAs		Proteins for ACE2
	Lentivirus-delivered shRNAs for ACE2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
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	Chimera RNAi (ACE2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Angiotensin Converting Enzyme 2)
	Antibodies (Angiotensin Converting Enzyme 2)

Search OriGene for ACE2

Tocris compounds for ACE2

	Drugs/Proteins for ACE2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACE2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ACE2 Gene at Home site.
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ACE2 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ACE2

Summaries
for ACE2

Genomic Location
for ACE2

Proteins
for ACE2

Protein Domains/
Families
for ACE2

Gene Function
for ACE2

Pathways & Interactions
for ACE2

Drugs & Compounds
for ACE2

Transcripts
for ACE2

Expression
for ACE2

Orthologs
for ACE2

Paralogs
for ACE2

SNPs/Variants
for ACE2

Disorders & Mutations
for ACE2

Medical News
for ACE2

Publications
for ACE2

Search for ACE2

Genome Databases showing ACE2

Other Databases showing ACE2

Specialized Databases showing ACE2

Licensable Technologies
for ACE2

Services
for ACE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACE2 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ACE2

Summariesfor ACE2

Genomic Locationfor ACE2

Proteinsfor ACE2

Protein Domains/Familiesfor ACE2

Gene Functionfor ACE2

Pathways & Interactionsfor ACE2

Drugs & Compoundsfor ACE2

Transcriptsfor ACE2

Expression for ACE2

Orthologsfor ACE2

Paralogsfor ACE2

SNPs/Variantsfor ACE2

Disorders & Mutationsfor ACE2

Medical Newsfor ACE2

Publicationsfor ACE2

Search for ACE2

Genome Databases showing ACE2

Other Databases showing ACE2

Specialized Databases showing ACE2

Licensable Technologiesfor ACE2

Servicesfor ACE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACE2

Summaries
for ACE2

Genomic Location
for ACE2

Proteins
for ACE2

Protein Domains/
Families
for ACE2

Gene Function
for ACE2

Pathways & Interactions
for ACE2

Drugs & Compounds
for ACE2

Transcripts
for ACE2

Expression
for ACE2

Orthologs
for ACE2

Paralogs
for ACE2

SNPs/Variants
for ACE2

Disorders & Mutations
for ACE2

Medical News
for ACE2

Publications
for ACE2

Licensable Technologies
for ACE2

Services
for ACE2