Aliases for ACE Gene
External Ids for ACE Gene
Previous HGNC Symbols for ACE Gene
Previous GeneCards Identifiers for ACE Gene
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
GeneCards Summary for ACE Gene
ACE (Angiotensin I Converting Enzyme) is a Protein Coding gene. Diseases associated with ACE include microvascular complications of diabetes 3 and renal tubular dysgenesis, ace-related. Among its related pathways are p70S6K Signaling and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include actin binding and drug binding. An important paralog of this gene is TMEM27.
UniProtKB/Swiss-Prot for ACE Gene
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety
Angiotensin-converting enzyme (ACE, aka peptidyl dipeptidase A, carboxycathepsin) cleaves a C-terminal dipeptide from angiotensin I to create the vasoconstrictor peptide, angiotensin II. ACE can also inactivate the vasodilator peptide, bradykinin. There are two isoforms of ACE, a smaller/single catalytic site enzyme found in the testes and a more widely expressed ~180kDa dual active site isoform. ACE is often membrane bound. In contrast to ACE, the homolog ACE2, has recently been shown to cleave and inactivate angiotensin II to generate the vasodilator Angiotensin (1-7). ACE inhibitors are widely used to treat hypertension and cardiovascular diseases. ACE inhibitors have also been used to slow nephropathy, particularly when it is associated with diabetes.