Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACE Gene

protein-coding GIFtS: 71
GCID: GC17P061554

angiotensin I converting enzyme (peptidyl-dipeptidase A)...

(Previous symbol: DCP1)

Explore 377 diseases affiliated with
ACE via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1¹ ²		Angiotensin Converting Enzyme, Somatic Isoform²
DCP1¹ ² ³ ⁵		Angiotensin I Converting Enzyme Peptidyl-Dipeptidase A 1 Transcript²
ACE1¹ ² ⁵		Angiotensin-Converting Enzyme²
CD143¹ ²		Carboxycathepsin¹
Dipeptidyl Carboxypeptidase I² ³		Dipeptidyl Carboxypeptidase 1²
Kininase II² ³		Peptidase P²
DCP² ³		Testicular ECA²
CD143 Antigen² ³		EC 3.2.1.-³
MVCD3² ⁵		EC 3.4.15.1³
ICH²

External Ids:	HGNC: 2707¹	Entrez Gene: 1636²	Ensembl: ENSG00000159640⁷	OMIM: 106180⁵	UniProtKB: P12821³

Export aliases for ACE gene to outside databases

Previous GC identifers: GC17P061205 GC17P063980 GC17P061895 GC17P062027 GC17P058908 GC17P056922

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACE:

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active

peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood

pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies

have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating

enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different

isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form,

respectively, that are equally active. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: ACE_HUMAN, P12821

Function: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of

the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a

glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI

moiety

summary for ACE:

Angiotensin-converting enzyme (ACE, aka peptidyl dipeptidase A, carboxycathepsin) cleaves a C-terminal

dipeptide from angiotensin I to create the vasoconstrictor peptide, angiotensin II. ACE can also inactivate

the vasodilator peptide, bradykinin. There are two isoforms of ACE, a smaller/single catalytic site enzyme

found in the testes and a more widely expressed ~180kDa dual active site isoform. ACE is often membrane

bound. In contrast to ACE, the homolog ACE2, has recently been shown to cleave and inactivate angiotensin II

to generate the vasodilator Angiotensin (1-7). ACE inhibitors are widely used to treat hypertension and

cardiovascular diseases. ACE inhibitors have also been used to slow nephropathy, particularly when it is

associated with diabetes.

Gene Wiki entry for ACE (Angiotensin-converting enzyme)

PharmGKB "VIP" summary for ACE

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACE gene promoter:
Sp1 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACE promoter sequence

Search SABiosciences Chromatin IP Primers for ACE

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACE

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23.3

ACE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACE gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P061554: view genomic region (about GC identifiers)

Start:	61,554,422 bp from pter	End:	61,599,205 bp from pter
Size:	44,784 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACE_HUMAN, P12821 (See protein sequence)

Recommended Name: Angiotensin-converting enzyme precursor

Size: 1306 amino acids; 149715 Da

Cofactor: Binds 2 zinc ions per subunit. Isoform Testis-specific only binds 1 zinc ion per subunit

Cofactor: Binds 3 chloride ions per subunit

Subcellular location: Angiotensin-converting enzyme, soluble form: Secreted

Subcellular location: Cell membrane; Single-pass type I membrane protein

Miscellaneous: Inhibitors of ACE are commonly used to treat hypertension and some types of renal and cardiac

dysfunction

Miscellaneous: The glycosidase activity probably uses different active site residues than the metalloprotease activity

Sequence caution: Sequence=BAD92208.1; Type=Erroneous initiation;

6/18 PDB 3D structures from and Proteopedia for ACE (see all 18):

1O86 (3D)

1O8A (3D)

1UZE (3D)

1UZF (3D)

2C6F (3D)

2C6N (3D)

Secondary accessions: B0LPF0 B4DXI3 E7EU16 P22966 Q53YX9 Q59GY8 Q7M4L4

Alternative splicing: 4 isoforms: P12821-1 P12821-2 P12821-3, P22966-1 P12821-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACE: NX_P12821

Post-translational modifications:

Phosphorylated by CK2 on Ser-1299; which allows membrane retention¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P12821

ACE Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000780.1 NP_001171528.1 NP_690043.1

ENSEMBL proteins:

ENSP00000462995 ENSP00000290866 ENSP00000462280 ENSP00000463302 ENSP00000463673

ENSP00000290863 ENSP00000462002 ENSP00000462110 ENSP00000392247 ENSP00000462599

ENSP00000464629 ENSP00000462909 ENSP00000464428 ENSP00000397593 ENSP00000439591

ENSP00000464539 ENSP00000387760

Reactome Protein details: P12821
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ACE (ACE/CD143)
	Enzo Life Sciences proteins for ACE
	OriGene Purified Protein: ACE OriGene Protein Over-expression Lysate: ACE OriGene Custom Protein Services for ACE
	GenScript Custom Purified and Recombinant Proteins Services for ACE
	Novus Biologicals ACE Protein Novus Biologicals ACE Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACE

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	4322742
GO:0005624	membrane fraction	--	--
GO:0005768	endosome	IDA	17077303
GO:0005886	plasma membrane	IDA	17077303
GO:0009897	external side of plasma membrane	IDA	9449382

ACE for ontologies About GeneDecksing

ACE Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ACE
	R&D Systems Antibodies for ACE (ACE/CD143)
	OriGene Antibodies: ACE OriGene Custom Antibody Services for ACE
	GenScript Custom Superior Antibodies Services for ACE
	Novus Biologicals ACE Antibodies
	Abcam antibodies for ACE
	Uscn Antibodies for ACE
	ThermoFisher Antibodies for ACE

Assay Products for ACE:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for ACE (ACE/CD143) (see all)
	GenScript ACE-Activity-based Protease Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ACE

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACE for domains About GeneDecksing

1 InterPro domain/family:

IPR001548 Peptidase_M2

Graphical View of Domain Structure for InterPro Entry P12821

ProtoNet protein and cluster: P12821

1 Blocks protein family: IPB001548 Peptidyl-dipeptidase A (M2) metalloprotease family signature

UniProtKB/Swiss-Prot: ACE_HUMAN, P12821

Similarity: Belongs to the peptidase M2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACE_HUMAN, P12821

Function: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of

the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a

glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI

moiety

Catalytic activity: Release of a C-terminal dipeptide, oligopeptide- -Xaa-Yaa, when Xaa is not Pro, and Yaa is neither

Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no

action on angiotensin II

Enzyme regulation: Strongly activated by chloride. Specifically inhibited by lisinopril, captopril and enalaprilat

Biophysicochemical properties: Kinetic parameters: KM=2.51 mM for Hip-His-Leu;

Induction: Up-regulated in failing heart

Enzyme Numbers (IUBMB): EC 3.2.1.-¹ EC 3.4.15.1¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ACE Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACE
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ACE (see all 9):
		hsa-miR-4297 hsa-miR-27a hsa-miR-513a-5p hsa-miR-340 hsa-miR-3126-5p hsa-miR-3119 hsa-miR-630 hsa-miR-1286

		SwitchGear 3'UTR luciferase reporter plasmid: ACE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACE (see all 7) OriGene shRNA RFP: ACE OriGene siRNA: ACE
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACE

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ACE

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACE (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACE (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ACE (NM_000789)
		Sino Biological Human cDNA Clone for ACE
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACE
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACE

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ACE
		Search LifeMap BioReagents cell lines for ACE

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACE

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	16186248
GO:0004175	endopeptidase activity	IDA	15283675
GO:0004180	carboxypeptidase activity	IEA	--
GO:0005515	protein binding	IPI	16186248
GO:0008144	drug binding	IDA	1320019

ACE for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ACE:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for ACE: Ace^tm1Mcf Ace^tm1Unc Ace^tm2Unc Ace^tm1Keb Ace^tm4Keb Ace^tm2Keb
14 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Ace):

adipose tissue	behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system
mortality/aging	renal/urinary system	reproductive system	tumorigenesis

ACE for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

	ACE Inhibitor Pathway, Pharmacodynamics	1.00			ACE Inhibitor Pathway	0.85
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics	1.00

Renin-angiotensin system

Renin-angiotensin system

1.00

Metabolism of Angiotensinogen to Angiotensins

0.48

Transcription_CREM signaling in testis

Transcription_CREM signaling in testis

1.00

A-beta Uptake & Degradation

A-beta Uptake & Degradation

1.00

Hypertrophic cardiomyopathy (HCM)

Hypertrophic cardiomyopathy (HCM)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for ACE

A-beta Uptake & Degradation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ACE

Renin-Angiotensin Pathway

1 GeneGo (Thomson Reuters) Pathway for ACE

Transcription CREM signaling in testis

1 BioSystems Pathway for ACE

ACE Inhibitor Pathway

3 Reactome Pathways for ACE

	Metabolism of Angiotensinogen to Angiotensins
	Metabolism of proteins
	Peptide hormone metabolism

2 PharmGKB Pathways for ACE

	ACE Inhibitor Pathway, Pharmacodynamics
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for ACE):

	Renin-angiotensin system
	Chagas disease (American trypanosomiasis)
	Hypertrophic cardiomyopathy (HCM)

ACE for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ACE

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for ACE (P12821³ ENSP00000290866⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGTR2	P50052³, ENSP00000360973⁴	I2D: score=1 STRING: ENSP00000360973
COMT	P21964³, ENSP00000354511⁴	I2D: score=1 STRING: ENSP00000354511
BDKRB2	P30411³, ENSP00000307713⁴	I2D: score=1 STRING: ENSP00000307713
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
ACE2	ENSP00000252519⁴	STRING: ENSP00000252519

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	--	--
GO:0001822	kidney development	IMP	16116425
GO:0001974	blood vessel remodeling	IC	1668266
GO:0002005	angiotensin catabolic process in blood	IC	1668266
GO:0002019	regulation of renal output by angiotensin	IC	1668266

ACE for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ACE for compounds About GeneDecksing

EMD Millipore small molecules for ACE:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for ACE

Compounds for ACE available from Tocris Bioscience About this table

Compound	Action	CAS #
Angiotensin I (human, mouse, rat)	Endogenous precursor to angiotensin II (Cat. No. 1158)	[484-42-4]
Benazepril hydrochloride	Angiotensin-converting enzyme (ACE) inhibitor	[86541-74-4]
Moexipril hydrochloride	Angiotensin-converting enzyme (ACE) inhibitor	[82586-52-5]
Captopril	ACE inhibitor; also inhibits LTA4 hydrolase	[62571-86-2]
Perindopril erbumine	Angiotensin-converting enzyme (ACE) inhibitor	[107133-36-8]

5 HMDB Compounds for ACE About this table

Compound	Synonyms	CAS #	PubMed Ids
Angiotensin II	Hypertensin (see all 11)	11128-99-7	--
Bradykinin	Callidin I (see all 5)	58-82-2	--
Chlorine	Cl2 (see all 13)	16887-00-6	--
Lisinopril	Acerbon (see all 34)	83915-83-7	--
Zinc	Zinc (see all 2)	7440-66-6	--

10/16 DrugBank Compounds for ACE (see all 16) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Captopril	Captoprilum [INN-Latin] (see all 3)	62571-86-2	target	inhibitor	20014331 17618628 11929321 11030016 15236580 11752352 16889963
Cilazapril	--	92077-78-6	target	inhibitor	18423812 10398211 1382157 11752352 10446934 1382161 10205231
Lisinopril	--	83915-83-7	target	inhibitor	17618628 9506845 11929321 11030016 11752352
Spirapril	--	83647-97-6	target	inhibitor	11929321 20524801 11752352 12613273 16126915
Enalapril	Enalapril Maleate (see all 4)	75847-73-3	target	inhibitor	17618628 16424790 15236580 11752352
Fosinopril	--	98048-97-6	target	inhibitor	2836111 11329095 11030016 11752352
Moexipril	Moexipril HCl (see all 3)	103775-10-6	target	inhibitor	7473177 11929321 11752352 15286086
Perindopril	--	107133-36-8	target	inhibitor	16370923 11929321 11752352 19379059
Quinapril	Quinapril HCl (see all 3)	85441-61-8	target	inhibitor	11929321 11752352 3020249 11817979
Ramipril	--	87333-19-5	target	inhibitor	16398929 11929321 11030016 11752352

10/127 Novoseek chemical compound relationships for ACE gene (see all 127) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
enalapril	93.5	720	7742150 (6), 11205963 (5), 1330361 (4), 9723634 (4) (see all 99)
captopril	92.7	883	1847704 (5), 16394648 (5), 1330361 (4), 8074019 (4) (see all 99)
lisinopril	92.4	420	9061270 (4), 1327597 (4), 8891468 (4), 18483087 (4) (see all 99)
ramipril	91.6	389	12423701 (4), 1837563 (3), 1725019 (3), 12639174 (3) (see all 99)
perindopril	90.3	384	9236432 (6), 1327597 (5), 19379059 (5), 10800878 (4) (see all 99)
fosinopril	88.4	164	1646240 (4), 7919557 (3), 8861547 (3), 8934359 (3) (see all 98)
quinapril	88.3	255	7527326 (7), 9049577 (5), 10024837 (4), 2068835 (4) (see all 99)
enalaprilat	88.2	223	10082496 (4), 9815869 (4), 11827728 (3), 1656995 (3) (see all 99)
trandolapril	86.4	138	7527095 (5), 9829159 (4), 12669106 (3), 17711535 (3) (see all 93)
cilazapril	85.9	145	7614501 (4), 11108164 (4), 1689417 (3), 2139303 (3) (see all 97)

3 PharmGKB related drug/compound annotations for ACE gene

Drug/compound	PharmGKB Annotation
hydrochlorothiazide	CA
sildenafil	CA
spironolactone	CA

About this table

Search CenterWatch for drugs/clinical trials and news about ACE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACE gene (4 alternative transcripts):

NM_000789.3 NM_001178057.1 NM_152830.2 NM_152831.1

Unigene Cluster for ACE:

Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Hs.298469 [show with all ESTs]

Unigene Representative Sequence: JQ927553

18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):

ENST00000583336 ENST00000584529 ENST00000582678(uc010ddu.2) ENST00000579462(uc010wph.2)

ENST00000290866(uc002jau.2) ENST00000582627 ENST00000580318 ENST00000579726

ENST00000290863(uc002jav.2 uc010wpj.2 uc010wpk.2) ENST00000582005

ENST00000578839 ENST00000413513 ENST00000579314(uc010ddv.2) ENST00000579204

ENST00000584865 ENST00000582761 ENST00000577418 ENST00000583645

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ACE Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACE
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ACE (see all 9):
		hsa-miR-4297 hsa-miR-27a hsa-miR-513a-5p hsa-miR-340 hsa-miR-3126-5p hsa-miR-3119 hsa-miR-630 hsa-miR-1286

		SwitchGear 3'UTR luciferase reporter plasmid: ACE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACE (see all 7) OriGene shRNA RFP: ACE OriGene siRNA: ACE
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACE

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACE (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACE (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ACE (NM_000789)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACE
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACE

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACE Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ACE
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACE
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACE

Additional cDNA sequence:

AB208971.1 AK296566.1 AK301988.1 J04144.1 JQ927553.1 M26657.1 S81361.1 X16295.1

13 DOTS entries:

DT.450544 DT.95220519 DT.100790782 DT.75103816 DT.100790780 DT.86854701 DT.100790785 DT.95220571

DT.100770455 DT.100776952 DT.40116291 DT.95220617 DT.95322212

24/223 AceView cDNA sequences (see all 223):

NM_152831 BQ881320 BE382576 CD364763 BF196049 BI831717 BX380082 AI096704

NM_000789 BG152896 BE783248 H27155 BE464066 AW003214 AI371868 AW772527

BQ020350 AW772446 BM712523 J04144 BM984583 BF475825 BI826471 NM_152830

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ACE (see all 14) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	^	16a	·	16b	^	17	^	18a	·	18b	^
SP1:			-				-																												-		-		-		-				-		-				-
SP2:																																													-		-				-
SP3:																																													-		-				-
SP4:																																									-				-		-				-
SP5:																																													-		-

ExUns:	19a	·	19b	·	19c	^	20a	·	20b	^	21	^	22	^	23a	·	23b	^	24	^	25a	·	25b	^	26	^	27	^	28	^	29a	·	29b
SP1:	-						-														-
SP2:	-						-														-
SP3:	-																				-
SP4:	-						-
SP5:	-						-

ECgene alternative splicing isoforms for ACE

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAGAAGCT

About this image

ACE expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Bone Marrow

Hematopoietic Stem Cells

Blood

Kidney

Proximal Tubule

Proximal Tubule Cells

Kidney

Skeletal Muscle

Hyoid Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Mandibular Arch Muscles

Skeletal Muscle

Brain

Brain

Heart

Kidney

Kidney

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ACE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACE

SOURCE GeneReport for Unigene cluster: Hs.298469

UniProtKB/Swiss-Prot: ACE_HUMAN, P12821

Tissue specificity: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and

prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis

SABiosciences Expression via Pathway-Focused PCR Arrays including ACE:

Hypertension in human mouse rat

Endothelial Cell Biology in human mouse rat

Atherosclerosis in human mouse rat

Diabetes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACE Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ACE
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACE
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACE

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ACE gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACE¹	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 less	70.99(n) 68.28(a)		419953 NM_001167732.1 NP_001161204.1
lizard (Anolis carolinensis)	Reptilia	ACE⁶	--	64(a)	1 → many	6(61166678-61223235)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.5776²	Transcribed sequence with weak similarity to protein spP22966 (H.sapiens) ACET_HUMAN Angiotensin-converting enzyme, testis-specific isoform precursor (ACE-T) (Dipeptidyl carboxypeptidase I) (Kininase II) less	77.22(n)		BQ526772.1
zebrafish (Danio rerio)	Actinopterygii	ace¹	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 less	67.07(n) 65.7(a)		565980 XM_689244.5 XP_694336.5
fruit fly (Drosophila melanogaster)	Insecta	Ance³	peptidyl-dipeptidase A	44(a) (best of 6)		2 34E2 --

ENSEMBL Gene Tree for ACE (if available)
TreeFam Gene Tree for ACE (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ACE gene

TMEM27² ENSG00000264813² ACE2²

1 SIMAP similar gene for ACE using alignment to 21 protein entries: ACE_HUMAN (see all proteins):

ACE2

ACE for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78041935^1,2	F	--	56921425(+)	`TAGTGC/ATAGGG`	1	--	us2k¹		1		NA	4
rs73992133^1,2	C,	--	56921604(+)	`ACCATC/GCCCCA`	1	--	us2k¹		2		WA	120
rs79477831^1,2	F,	--	56921921(+)	`CAGGGG/AAGTGT`	1	--	us2k¹		1		WA	118
rs4291^1,2	C,F,H,	--	56922553(+)	`TCTTCA/TAAAGA`	1	--	us2k¹		8		EA NA NS WA	1366
rs1110991^1,2	C	--	56922859(+)	`ctgccG/Cctgcc`	2	/P	syn¹ ese³		1		NS	534
rs7211207^1,2	C,A,	--	56923272(+)	`TGAGGG/CTGGCT`	1	--	int¹		2		WA	120
rs9896551^1,2	C,	--	56923541(+)	`CCCGGG/TCTCTG`	1	--	int¹		4		NA	184
rs3729659^1,2	C,F	--	56923812(+)	`AAGCGG/TCAGCA`	2	R	syn¹ ese³		1		NA	2772
rs12709417^1,2	C,F,	--	56923950(+)	`GCCCAG/AGTAAG`	1	--	int¹		2		--	184
rs12709418^1,2	C,F,	--	56923987(+)	`TTTTCT/CTGGAG`	1	--	int¹		3		WA	302
rs12709419^1,2	C,	--	56924043(+)	`GGAAGC/TCAAAT`	1	--	int¹		6		NS NA	722
rs12720748^1,2	C,F,	--	56924087(+)	`CTTCTT/CTGGAA`	1	--	int¹		2		WA	208
rs12720749^1,2	C,F,	--	56924119(+)	`GGTGGC/TTCAAG`	1	--	int¹		1		--	88
rs4294^1,2	C,	--	56924383(+)	`CCCCCA/CAAAAA`	1	--	int¹ trp³		5		NA WA	298
rs760281^1,2	H	--	56924492(+)	`GACCCT/AGACCC`	1	--	int¹		4		NS EA	414
rs113571237^1,2	F,	--	56924525(+)	`CCACTG/CCACAG`	1	--	int¹		2		CSA	4
rs75214560^1,2	C,	--	56924763(+)	`TCTACC/TCCACC`	2	P S	mis¹		0	--	--	--	--
rs4297^1,2	C,F,H,	--	56924913(-)	`TGTCTC/GCACAG`	1	--	int¹		12		NS EA NA WA	1468
rs3730021^1,2	H	--	56925474(+)	`CCTGCC/TTGCCT`	1	--	int¹		4		NS EA	406
rs3730022^1,2	C,F	--	56925514(+)	`TCCTCG/TCGAAG`	2	S	syn¹ ese³		1		NA	4552
rs4299^1,2	C,F,H	--	56925577(+)	`CCGCTG/AAAACC`	2	/L	syn¹ ese³		6		MN NS EA NA	5144
rs111349805^1,2	F	--	56925777(+)	`GGACCG/AGCCTG`	1	--	int¹		2		CSA	4
rs12720741^1,2	C,F,	--	56926640(+)	`GCCCTC/AGGAGG`	1	--	int¹		2		WA	202
rs12709424^1,2	C,F,	--	56926679(+)	`TCTGGC/TCCTAA`	1	--	int¹		3		WA	286
rs4306^1,2	C,	--	56926757(+)	`ATGAAG/AAAGCA`	1	--	int¹		2		CSA WA	120
rs34126458^1,2	C,F,	--	56927295(-)	`CGTGGC/AGTTCC`	2	/A /S	mis¹		2		NA EU	1206
rs3730026^1,2	C	--	56927360(+)	`CCTCCC/TGAGTT`	2	P	syn¹ ese³		1		EA	96
rs1554961^1,2	C,	--	56927603(+)	`CAGGGC/TTAGGG`	1	--	int¹		4		EA NA NS	590
rs55917477^1,2	C,	--	56927745(+)	`AGGCAC/TGGTGG`	1	--	int¹		0	--	--	--	--
rs13306085^1,2	H	--	56928203(+)	`CACACG/AGGTCA`	2	/Q /R	mis¹ ese³		6		EA NS NA	504
rs12709425^1,2	C,	--	56929020(+)	`CCCACC/TGCCTT`	3	--	int¹ us2k¹		5		NA WA	310
rs111625159^1,2	C,F,	--	56929095(+)	`GTTGCC/TGNNNN`	3	--	us2k¹ int¹		1		NA	120
rs12720746^1,2	C,H	--	56929263(+)	`AAATGT/CGACAC`	4	/A /V	us2k¹ mis¹		9		NS EA NA	5066
rs4312^1,2	C,F,	--	56929345(+)	`CTGTGA/TTCCTA`	3	--	us2k¹ int¹		12		NS NA CSA WA EA	2006
rs4313^1,2	C,F,	--	56929376(+)	`TGTCCC/TCATGC`	3	--	int¹ us2k¹		11		MN NS NA WA CSA	1006
rs111269527^1,2	C,F	--	56930192(+)	`AGAACG/AGCGAG`	4	/S /G	mis¹ us2k¹		2		CSA NA	4192
rs112810708^1,2		--	56930422(+)	`GAGTGG/CGGACA`	3	--	us2k¹ int¹		1		CSA	2
rs12720723^1,2	C,F,	--	56930530(+)	`ACTGCG/AGGCTC`	3	--	int¹ us2k¹		2		WA	208
rs4319^1,2	C	--	56930851(+)	`GACAG-/GGGCAG`	3	--	int¹		0	--	--	--	--
rs4322^1,2	C,	--	56931238(+)	`GCTCAC/TGCCTG`	3	--	int¹		1		CSA	2
rs12709428^1,2	C,F,	--	56931737(+)	`AAGTCG/ATTTTT`	3	--	int¹		3		WA	306
rs4328^1,2	C,F,	--	56931772(+)	`TCTCCT/CCTACA`	3	--	int¹		7		NA WA	314
rs12720730^1,2	C,	--	56932074(+)	`TTGACC/TGCAGG`	3	--	int¹		2		CSA	84
rs12709429^1,2	C	--	56932819(+)	`TGAGTG/CAGAGG`	3	--	int¹		5		NS NA	218
rs55907121^1,2	C	--	56932892(+)	`TCGCTC/GTTGGG`	3	--	int¹		0	--	--	--	--
rs74724462^1,2		--	56933051(+)	`GTCCTC/TTCTGC`	3	--	int¹		0	--	--	--	--
rs12720732^1,2	C,F,	--	56933057(+)	`TCTGCA/GTGCCG`	3	--	int¹		2		WA	212
rs12720731^1,2	C,F,	--	56933064(+)	`GCCGCC/GCCTCA`	3	--	int¹		8		WA CSA EA	1265
rs75535843^1,2	F,	--	56933147(+)	`CCCCCG/AGCCTC`	3	--	int¹		1		EA	120
rs12709430^1,2	C,F,H,	--	56933428(+)	`CACACA/GGATAC`	3	--	int¹		8		NA NS EA WA	718
rs4338^1,2	C,	--	56933586(+)	`TGGAAA/GATAAA`	3	--	int¹		2		NA	122
rs4339^1,2	C,	--	56933660(+)	`CAAGTG/TTGAGG`	3	--	int¹		4		NA WA	1220
rs1987693^1,2	A,H,	--	56934124(+)	`AAGCAC/TGCCCC`	3	--	int¹		5		NS EA WA	528
rs12709431^1,2	C,F	--	56934610(+)	`CCTGGA/CGGAGG`	3	--	int¹		2		--	168
rs35580653^1,2	C,F	--	56934698(-)	`GTCTCG/ATACAT`	6	/Y	syn¹		2		NA	4582
rs62075042^1,2		--	56934962(+)	`AGACTC/TCAGCC`	3	--	int¹		1		NA	2
rs4345^1,2	C,F,H,	--	56935304(+)	`AGAAGA/GACCTG`	3	--	int¹		5		NS EA CSA	402
rs74366947^1,2	F,	--	56935474(+)	`CACTTT/CCCTGG`	3	--	int¹		1		WA	118
rs74406875^1,2	F	--	56935728(+)	`CCTTAG/AAACTC`	3	--	int¹		1		NA	4
rs112679892^1,2		--	56935796(+)	`TGTCTG/CTCTCT`	3	--	int¹		1		CSA	2
rs12709432^1,2	C	--	56936858(+)	`TCCCCC/GGGGAT`	3	--	int¹		4		NS NA	230
rs3730042^1,2	C,	--	56936877(+)	`CAGCAC/TGCAGT`	3	--	int¹		1		WA	118
rs12709434^1,2	C,H,	--	56937335(+)	`GGAAGT/CGCTCA`	3	--	int¹		9		NS EA NA	648
rs12709435^1,2	C,	--	56937379(+)	`GCCCCG/ACGTCC`	3	--	int¹		4		NA WA	316
rs4349^1,2	C,F,H,	--	56937503(+)	`ACAGGC/TTCAGA`	3	--	int¹		16		NS EA NA WA	1766
rs12720727^1,2	H	--	56937592(+)	`CAACCA/GGTTGA`	3	--	int¹		5		NS EA	500
rs12709436^1,2	C,	--	56937887(+)	`TCGGGC/TGCCCT`	3	--	int¹		4		WA	308
rs4350^1,2	C,	--	56937899(+)	`CCAGCG/ATGGAA`	3	--	int¹		4		CSA WA	307
rs4352^1,2	C,	--	56938540(+)	`ggttcA/Gagacc`	3	--	int¹		0	--	--	--	--
rs12936400^1,2	H	--	56938599(+)	`AATGAG/CAACAA`	3	--	int¹		2		NS	218
rs112008404^1,2		--	56938661(+)	`CTGCCG/ATTCAT`	3	--	int¹		1		CSA	2
rs13306084^1,2	H	--	56939494(+)	`GCAATC/TGGAAG`	3	--	int¹		5		EA NS	494
rs12709437^1,2	C,	--	56939569(+)	`CCCCTC/TCNNNN`	3	--	int¹		5		NS NA	766
rs12709438^1,2	C,F	--	56939829(+)	`CTCTGC/TGAGTG`	3	--	int¹		2		--	172
rs4356^1,2	C,	--	56939927(+)	`TGGTGT/CAAGTG`	3	--	int¹		5		NA WA	298
rs76490402^1,2		--	56939972(+)	`AGCACA/GCAGGA`	3	--	int¹		0	--	--	--	--
rs4357^1,2	C,F,H,	--	56939989(+)	`GGTGCC/TCAGTA`	3	--	int¹		17		NA EA NS WA	2094
rs4358^1,2	C,F,	--	56940266(+)	`TGCCCG/AGTCCA`	3	--	int¹		11		NS NA WA CSA EA	886
rs12720725^1,2	C,F,	--	56940628(+)	`AGATCG/AGTTAA`	3	--	int¹		2		WA	212
rs12709439^1,2	C,	--	56941055(+)	`AGTTCC/TAGGTG`	3	--	int¹		6		NS NA	358
rs12720740^1,2	C,F,	--	56941337(+)	`CTCCCG/ACCTGC`	3	--	int¹		2		WA	208
rs75310560^1,2	F	--	56941346(+)	`GCCTGC/ATGGAG`	3	--	int¹		1		NA	6
rs12709440^1,2	C	--	56941534(+)	`AGACCA/GGGGAA`	3	--	int¹		4		NS NA	236
rs111369717^1,2		--	56941949(+)	`GGGGTG/TGGGGA`	3	--	int¹		1		CSA	2
rs12709441^1,2	C,F,	--	56941989(+)	`GGGGGC/TCTTGG`	3	--	int¹		2		--	184
rs4361^1,2	C,	--	56942024(+)	`CACACA/GTCACA`	3	--	int¹		0	--	--	--	--
rs12720743^1,2	C,	--	56942726(+)	`CCACCT/-CCAGC`	3	--	int¹		3		CSA	98
rs111618613^1,2		--	56943591(+)	`GGACTG/CTGGGA`	3	--	ut3¹		1		CSA	2
rs74979666^1,2		--	56943672(+)	`CAGGTA/CCCCCC`	3	--	ut3¹		0	--	--	--	--
rs112901380^1,2	C,	--	56943795(+)	`CTCCTG/ACCTGT`	3	--	ut3¹		1		CSA	2
rs78716020^1,2	F,	--	56943980(+)	`CATTGG/AAGGGA`	3	--	ut3¹		1		WA	118
rs9894286^1,2	C,F,H,	--	56944391(+)	`AATATC/GTGTCC`	3	--	ds500¹		8		NS EA NA	712
rs142328237^1,2	C,F,	--	59625245(+)	`CGCCTC/G/TGGCTT`	3	S W L	mis¹		1		NA	4530
rs116003739^1,2	F,	--	61552476(+)	`CAATGC/GCCGCC`	1	--	us2k¹		1		WA	118
rs183197712^1,2		--	61552524(+)	`GAGGCA/GAGGCC`	1	--	us2k¹		0	--	--	--	--
rs188607152^1,2		--	61552618(+)	`TTCAGA/GGGCTG`	1	--	us2k¹		0	--	--	--	--
rs199577871^1,2		--	61552669(+)	`TCCAC-/AGAAAGA`	1	--	us2k¹		0	--	--	--	--
rs192218674^1,2		--	61552709(+)	`TTTGCA/GCACAG`	1	--	us2k¹		0	--	--	--	--
rs184416647^1,2		--	61552862(+)	`ACCAAA/CGTAGC`	1	--	us2k¹		0	--	--	--	--
rs147236808^1,2		--	61553012(+)	`CCTCTC/TCCGGC`	1	--	us2k¹		0	--	--	--	--
rs140738669^1,2		--	61553098(+)	`CCACCA/GCCCCC`	1	--	us2k¹		0	--	--	--	--
rs144701461^1,2		--	61553193(+)	`CACACA/TCTCCA`	1	--	us2k¹		0	--	--	--	--
rs187604747^1,2		--	61553297(+)	`CCTAAC/TGGGTT`	1	--	us2k¹		0	--	--	--	--
rs13306086^1,2	C,F,H	--	61554231(+)	`TGCGGG/AAGCCC`	1	--	us2k¹		5		EA NS	604
rs192538126^1,2		--	61554253(+)	`ATCCCA/GCCACC`	1	--	us2k¹		0	--	--	--	--
rs4292^1,2	C,F,H,	--	61554341(+)	`GGACTT/CTGGAG`	1	--	us2k¹		9		EA NA NS CSA	1309
rs147912715^1,2	C,	--	61554632(+)	`GAACAA/GGTGCT`	2	Q	syn¹		0	--	--	--	--
rs184457276^1,2		--	61554686(+)	`ACCGCA/GGAGAA`	2	A	syn¹		0	--	--	--	--
rs189334234^1,2		--	61554807(+)	`CGAACC/GCCACC`	1	--	int¹		0	--	--	--	--
rs181234076^1,2		--	61554833(+)	`CGCCCC/GGACAG`	1	--	int¹		0	--	--	--	--
rs149083340^1,2		--	61554988(+)	`GGGCAA/GCTGCC`	1	--	int¹		0	--	--	--	--
rs114000559^1,2	C,F,	--	61555467(+)	`GGGCTG/AAGGGC`	1	--	int¹		1		WA	118
rs4293^1,2	C,F,A,H,	--	61555666(+)	`AGGAAG/ACATTC`	1	--	int¹		32		NS EA NA WA	3854
rs145576748^1,2		--	61555691(+)	`AAATTA/CAAATA`	1	--	int¹		0	--	--	--	--
rs184884873^1,2		--	61555768(+)	`AAGCCA/TGTAAT`	1	--	int¹		0	--	--	--	--
rs188753862^1,2		--	61555778(+)	`TCCCAA/GCACTT`	1	--	int¹		0	--	--	--	--
rs181487222^1,2		--	61556077(+)	`AGCCAC/GAGAAT`	1	--	int¹		0	--	--	--	--
rs140827874^1,2		--	61556097(+)	`CTGCCC/TTCACT`	1	--	int¹		0	--	--	--	--
rs186118049^1,2		--	61556138(+)	`TGACCC/TTGACT`	1	--	int¹		0	--	--	--	--
rs190837090^1,2		--	61556179(+)	`TGCCTC/TCACTG`	1	--	int¹		0	--	--	--	--
rs4295^1,2	C,F,A,H,	--	61556298(-)	`TGCTAC/GAAGGA`	1	--	int¹ trp³		30		NS EA NA WA CSA	5061
rs182340837^1,2	C,	--	61556342(+)	`ACTGGA/CGCATT`	1	--	int¹		0	--	--	--	--
rs201716509^1,2		--	61556389(+)	`GCAACA/GTGAGC`	2	M V	mis¹		0	--	--	--	--
rs201277497^1,2		--	61556408(+)	`CTCCAC/TCGCCA`	2	T I	mis¹		0	--	--	--	--
rs13306087^1,2	C,	--	61556410(+)	`CCACCG/ACCAAG`	2	/T /A	mis¹ ese³		4		EA NA	4634
rs143320537^1,2	C,F,	--	61556415(+)	`GCCAAG/CGTCTG`	2	/N /K	mis¹		1		NA	4532
rs148351680^1,2	C,F,	--	61556424(+)	`TGCCTC/TCCCAA`	2	L	syn¹		1		NA	4532
rs201285321^1,2		--	61556427(+)	`CTCCCC/TAACAA`	2	P	syn¹		0	--	--	--	--
rs117134739^1,2	C,	--	61556429(+)	`CCCCAA/GCAAGA`	2	N S	mis¹		2		EA NA	4650
rs139076951^1,2	C,F	--	61556453(+)	`GTCCCT/CGGACC`	2	/P /L	mis¹		1		NA	4502
rs4296^1,2	C,A,H,	--	61556527(+)	`ACTCCG/AGACCA`	1	--	int¹		16		EA NA WA CSA	998
rs149402509^1,2		--	61556589(+)	`CTCCAA/GCTGGG`	1	--	int¹		0	--	--	--	--
rs186057920^1,2		--	61556782(+)	`GGGACA/CCCTCG`	1	--	int¹		0	--	--	--	--
rs190922156^1,2		--	61556807(+)	`ACCCCG/TCTCCA`	1	--	int¹		0	--	--	--	--
rs115956722^1,2	C,F,	--	61557016(+)	`GGCACC/TGTGAT`	1	--	int¹		1		WA	118
rs12720754^1,2	C,F,	--	61557165(+)	`GCTACG/ACCATG`	2	/T /A	mis¹ ese³		2		NA	4642
rs4298^1,2	C,F,A,	--	61557200(+)	`CACAAC/TGCTGC`	2	N	syn¹		19		MN EA NA NS WA CSA EU	7607
rs148460287^1,2	C,F	--	61557223(+)	`GAAACC/TGCTGT`	2	P L	mis¹		1		NA	4542
rs148144906^1,2	C,	--	61557250(+)	`CCTCAG/TCAATG`	2	S I	mis¹		0	--	--	--	--
rs4300^1,2	C,F,	--	61557286(+)	`GGCCTC/TTCCCT`	1	--	int¹		7		NA WA EU	1103
rs183190490^1,2	C,	--	61557305(+)	`ACCACA/GCCAGG`	1	--	int¹		0	--	--	--	--
rs187874395^1,2		--	61557353(+)	`GAGTCA/TGGCAG`	1	--	int¹		0	--	--	--	--
rs144066097^1,2		--	61557431(+)	`CCCAGC/TGTGCC`	1	--	int¹		0	--	--	--	--
rs200348541^1,2		--	61557655(+)	`GGTCCC/GAGCCT`	1	--	int¹		0	--	--	--	--
rs4301^1,2	C,H,	--	61557672(+)	`TGAGCC/TACATA`	1	--	int¹		4		NS EA	418
rs201356877^1,2		--	61557685(+)	`TCACCC/TCCACG`	1	--	int¹		0	--	--	--	--
rs12720734^1,2	C,	--	61557689(+)	`CCCCAC/TGCCCC`	1	--	int¹		2		CSA	92
rs141543325^1,2	C	--	61557724(+)	`ACTGGC/TGCTCC`	2	R C	mis¹		1		NA	4544
rs77294580^1,2	C,	--	61557757(+)	`AGGACA/GATCTG`	2	N D	mis¹		0	--	--	--	--
rs3730025^1,2	C,F,H,	--	61557773(+)	`CCTCTA/GCCAAC`	2	Y C	mis¹ ese³		12		NS EA NA EU	7085
rs200907466^1,2		--	61557800(+)	`CCTGAA/GCCTCC`	2	N S	mis¹		0	--	--	--	--
rs150011877^1,2	C,	--	61557821(+)	`CCGCCA/GCGCAC`	2	H R	mis¹		0	--	--	--	--
rs4302^1,2	C,F,	--	61557822(+)	`CGCCGC/TGCACT`	2	R	syn¹ ese³		5		MN NA CSA	4742
rs4303^1,2	C,F,H,	--	61557823(+)	`GCCGCG/TCACTG`	2	A S	mis¹ ese³		18		MN NS EA NA CSA WA EU	7896
rs138873311^1,2	F	--	61557835(+)	`ATCGCC/TGATAC`	2	R *	stg¹		1		NA	4552
rs149412997^1,2	C,F	--	61557841(+)	`GATACG/AGAGAC`	2	/R /G	mis¹		2		NA EU	5875
rs148882466^1,2	C,	--	61557861(+)	`AACCTC/TAGGGG`	2	L	syn¹		1		NA	4552
rs12709422^1,2	C,F,	--	61557901(+)	`ACCTGG/ACCTCG`	1	--	int¹		2		--	176
rs199579045^1,2		--	61557911(+)	`GCCTCC/TACATG`	1	--	int¹		0	--	--	--	--
rs182743175^1,2	C,	--	61557920(+)	`TGAGTC/TCCACG`	1	--	int¹		0	--	--	--	--
rs4304^1,2	C,F,	--	61557939(+)	`GGTCCC/TGAGGT`	1	--	int¹		6		NA WA	308
rs187392868^1,2		--	61558020(+)	`TACTGC/TTTGCT`	1	--	int¹		0	--	--	--	--
rs4305^1,2	C,F,A,H,	--	61558229(+)	`CTGGCA/GCAGCC`	1	--	int¹		25		EA NS NA CSA WA	5420
rs192454466^1,2		--	61558388(+)	`TCAGCA/GATGCA`	1	--	int¹		0	--	--	--	--
rs61740982^1,2	C,F,	--	61558493(+)	`ACATGG/ATGGTG`	2	/M /V	mis¹		2		NS NA	4614
rs150754995^1,2	F	--	61558531(+)	`GTCACC/TAGTAC`	2	T	syn¹		1		NA	4550
rs144137849^1,2	C,	--	61558532(+)	`TCACCA/GGTACT`	2	S G	mis¹		0	--	--	--	--
rs201588518^1,2		--	61558539(+)	`TACTAC/TGCTGC`	2	T M	mis¹		0	--	--	--	--
rs200623613^1,2		--	61558563(+)	`TGGGCC/TCAAGC`	1	--	int¹		0	--	--	--	--
rs201274031^1,2		--	61558565(+)	`GGCTCA/GAGCCT`	1	--	int¹		0	--	--	--	--
rs199908307^1,2		--	61558597(+)	`GGGGCA/GCAAAA`	1	--	int¹		0	--	--	--	--
rs146527324^1,2		--	61558732(+)	`GCTCCA/TCAGTG`	1	--	int¹		0	--	--	--	--
rs187775970^1,2		--	61558736(+)	`CACAGC/TGGCAG`	1	--	int¹		0	--	--	--	--
rs201977675^1,2		--	61558917(+)	`ACACCA/CCTCCT`	1	--	int¹		0	--	--	--	--
rs35141294^1,2	C,F,	--	61558951(-)	`CACCCG/AGAACA`	2	/R /W	mis¹		3		NA WA	4680
rs118145880^1,2	C,F,	--	61558956(+)	`CGGGTG/TGCAGA`	2	V	syn¹		3		NA EU	5927
rs192205417^1,2	C,	--	61558965(+)	`GAGGAA/GTTCTT`	2	E	syn¹		0	--	--	--	--
rs201456235^1,2		--	61559002(+)	`CTCCCA/GAGTTC`	2	K E	mis¹		0	--	--	--	--
rs200225958^1,2		--	61559009(+)	`GTTCTA/GGGAAG`	2	* W	stg¹		0	--	--	--	--
rs34680431^1,2	C,F,	--	61559019(-)	`AGCATC/GGACCC`	2	S	syn¹		6		NA NS EU	6467
rs2229839^1,2	C,F	--	61559033(+)	`GAAGCC/TGGCCG`	2	P L	mis¹		7		MN NA NS EU	6509
rs148193919^1,2	C,	--	61559038(+)	`CGGCCA/GACGGG`	2	N D	mis¹		0	--	--	--	--
rs142350301^1,2	C,F,	--	61559041(+)	`CCGACG/AGGCGG`	2	/R /G	mis¹		2		NA EU	5864
rs199690936^1,2		--	61559059(+)	`TGTGCC/TACGCC`	2	H Y	mis¹		0	--	--	--	--
rs114488574^1,2	C,	--	61559079(+)	`GACTTC/TTACAA`	2	F	syn¹		2		WA NA	4612
rs200713261^1,2		--	61559136(+)	`TCCCCA/GGTTCT`	1	--	int¹		0	--	--	--	--
rs188505094^1,2		--	61559455(+)	`GAGTTC/GGAGAC`	1	--	int¹		0	--	--	--	--
rs4307^1,2	C,F,	--	61559487(+)	`ACCCCG/ATCTCT`	1	--	int¹		3		NS NA	566
rs191783388^1,2		--	61559534(+)	`GCGGGC/TGCCTG`	1	--	int¹		0	--	--	--	--
rs144031372^1,2		--	61559557(+)	`CTCAGG/TAGGCT`	1	--	int¹		0	--	--	--	--
rs146902069^1,2		--	61559599(+)	`GGAGGC/TTGCAG`	1	--	int¹		0	--	--	--	--
rs4308^1,2	C,F,H,	--	61559625(+)	`CCACTG/ACAGGC`	1	--	int¹		12		NA NS WA CSA EA	931
rs184532428^1,2		--	61559736(+)	`TCATTC/TCTGTC`	1	--	int¹		0	--	--	--	--
rs114171593^1,2	F,	--	61559751(+)	`AGGTGC/ACAATC`	1	--	int¹		1		WA	118
rs199895553^1,2		--	61559781(+)	`GCCCTC/GTTCTG`	1	--	int¹		0	--	--	--	--
rs72845022^1,2	C,,	--	61559793(+)	`CCATCC/TGTCAC`	1	--	int¹		0	--	--	--	--
rs114861086^1,2	C,F,	--	61559819(+)	`CTCTAC/TGCCCC`	1	--	int¹		1		WA	118
rs139399357^1,2	C,	--	61559820(+)	`TCTACA/GCCCCA`	1	--	int¹		0	--	--	--	--
rs189243320^1,2	C,	--	61559827(+)	`CCCAGG/TATCAA`	2	R S	mis¹		0	--	--	--	--
rs150466411^1,2	C,F,	--	61559850(+)	`GGTCAC/TGATGG`	2	T M	mis¹		2		NA EU	5835
rs138418851^1,2	C	--	61559883(+)	`TGAGAT/CGGGCC`	2	/T /M	mis¹		1		NA	4548
rs4309^1,2	C,F,O,A,H,	--	61559923(+)	`CTGCCC/TGTCTC`	2	P	syn¹		29		MN EA NA NS WA EU	9658
rs201117983^1,2	C,	--	61559924(+)	`TGCCCA/GTCTCC`	2	I V	mis¹		0	--	--	--	--
rs145172277^1,2	C,F,	--	61559937(+)	`GCGTCG/AGGGGG`	2	/Q /R	mis¹		1		NA	4552
rs138521921^1,2	C,F,	--	61559950(+)	`AACCCC/TGGCTT`	2	P	syn¹		1		NA	4552
rs149252911^1,2	C,	--	61559951(+)	`ACCCCG/AGCTTC`	2	/S /G	mis¹		1		NA	4552
rs144494842^1,2	C,	--	61559967(+)	`GGCCAT/CTGGGG`	2	/T /I	mis¹		1		NA	4552
rs143321044^1,2	C,F,	--	61559983(+)	`CTGGCG/ACTCTC`	2	/A	syn¹		2		NA EU	5867
rs144657113^1,2	C,	--	61560019(+)	`AAAATC/TGGCCT`	2	I	syn¹		0	--	--	--	--
rs199697957^1,2		--	61560026(+)	`GCCTGC/GTGGAC`	2	L V	mis¹		0	--	--	--	--
rs35865660^1,2	C,F,	--	61560033(-)	`TGACAC/TGGTCC`	2	H R	mis¹		1		NA	4548
rs34241302^1,2	C,F,	--	61560049(-)	`ATACCC/GGTGTC`	2	T	syn¹		1		NA	4524
rs187328381^1,2		--	61560157(+)	`CTCCCA/GGCCCC`	1	--	int¹		0	--	--	--	--
rs190726855^1,2		--	61560159(+)	`CCCGGC/TCCCAG`	1	--	int¹		0	--	--	--	--
rs150648336^1,2		--	61560212(+)	`ACTGCA/GCCCAG`	3	--	us2k¹ int¹		0	--	--	--	--
rs180743408^1,2		--	61560316(+)	`GCCCCA/GCCAGC`	3	--	us2k¹ int¹		0	--	--	--	--
rs139287666^1,2	C,	--	61560373(+)	`CTTTCA/GTCTCA`	3	--	us2k¹ int¹		1		EU	1323
rs185115105^1,2	C,	--	61560395(+)	`AAAGTA/GACATC`	4	N D	us2k¹ mis¹		0	--	--	--	--
rs201540553^1,2	C,	--	61560491(+)	`GTGGGC/TGTACC`	4	R C	us2k¹ mis¹		1		EU	1321
rs28730839^1,2	C,F,	--	61560501(+)	`CCCCCC/GTTCCC`	4	P R	us2k¹ mis¹ trp³		1		NA	4552
rs149784122^1,2	C,F	--	61560506(+)	`CTTCCC/TGCTAC`	4	R C	us2k¹ mis¹		2		NA EU	5875
rs79703566^1,2	C	--	61560543(+)	`AGAGGA/GGGGAT`	3	--	us2k¹ int¹		0	--	--	--	--
rs76032387^1,2	C	--	61560544(+)	`GAGGAA/GGGATA`	3	--	us2k¹ int¹		0	--	--	--	--
rs80277908^1,2	C	--	61560545(+)	`AGGAGA/GGATAG`	3	--	us2k¹ int¹		0	--	--	--	--
rs199575405^1,2		--	61560547(+)	`GAGGGA/GTAGAA`	3	--	int¹ us2k¹		0	--	--	--	--
rs189924139^1,2		--	61560662(+)	`CCACCA/GCCTTC`	3	--	us2k¹ int¹		0	--	--	--	--
rs4311^1,2	C,F,H,	--	61560763(+)	`AAAAGC/TTAAAT`	3	--	us2k¹ int¹		37		EA NA NS WA CSA	5612
rs148943954^1,2	C,F	--	61560846(+)	`GTCCTC/GCTGTT`	4	P A	mis¹ us2k¹		2		NA EU	5873
rs201762720^1,2		--	61560873(+)	`ACTTTA/GATGCT`	4	N D	us2k¹ mis¹		0	--	--	--	--
rs144294634^1,2	C	--	61560876(+)	`TTGATG/TCTGGA`	4	A S	mis¹ us2k¹		1		NA	4552
rs12720747^1,2	C,F,	--	61560938(+)	`CACCCC/TACCCA`	3	--	us2k¹ int¹		3		CSA WA	214
rs200643044^1,2		--	61560951(+)	`CCAGT-/AACTGT`	3	--	int¹ us2k¹		0	--	--	--	--
rs144117363^1,2		--	61561000(+)	`GCCTCA/CTCCCC`	3	--	int¹ us2k¹		0	--	--	--	--
rs182675474^1,2		--	61561024(+)	`ATGCTC/TCTCCA`	3	--	us2k¹ int¹		0	--	--	--	--
rs200868732^1,2		--	61561172(+)	`TGGCCC/TCCCAT`	3	--	us2k¹ int¹		0	--	--	--	--
rs145152527^1,2	C,F,	--	61561278(+)	`TGAGGG/ACCCAC`	4	/D /G	us2k¹ mis¹		1		NA	4548
rs4314^1,2	C,F,H,	--	61561304(+)	`TCTACC/TGGTCC`	4	R W	mis¹ us2k¹ ese³		9		MN NS EA NA	6220
rs146515255^1,2	C,	--	61561375(+)	`AGGAGC/TGGCTG`	3	--	us2k¹ int¹		0	--	--	--	--
rs12709426^1,2	C,F,H,	--	61561756(+)	`CTTAGA/GTGCCC`	4	D G	us2k¹ mis¹		23		NS EA NA WA	6666
rs138812566^1,2	C,F,	--	61561853(+)	`TGGCCC/TGAGTA`	4	P	us2k¹ syn¹		2		NA EU	4321
rs200963739^1,2		--	61561861(+)	`GTACCA/GGTGGC`	4	Q R	mis¹ us2k¹		0	--	--	--	--
rs200255554^1,2		--	61561892(+)	`TACCCA/GGAGGG`	4	P	us2k¹ syn¹		0	--	--	--	--
rs72845024^1,2	C,,	--	61561896(+)	`CGGAGG/AGCATA`	4	/S /G	mis¹ us2k¹		1		EU	731
rs149747354^1,2		--	61562083(+)	`TTCCCC/TCAGCA`	3	--	us2k¹ int¹		0	--	--	--	--
rs191697444^1,2		--	61562170(+)	`CACTGC/TGGGCT`	3	--	us2k¹ int¹		0	--	--	--	--
rs71375895^1,2	C,F	--	61562178(+)	`GCTCCG/ACTCTT`	3	--	ut5¹ int¹		2		NA	4
rs4316^1,2	C,F,A,H,	--	61562309(+)	`GTCCCT/CAGCCA`	5	/P	int¹ syn¹		21		MN EA NS NA WA CSA EU	3101
rs4317^1,2	C,F,H,	--	61562322(+)	`AGGCAT/CCCCAA`	5	/P /S	mis¹ int¹ ese³		16		MN NS EA NA CSA WA EU	2271
rs4318^1,2	C,F,H,	--	61562373(+)	`CCAGCA/GGCCAG`	5	S G	int¹ mis¹ ese³		15		MN NS EA CSA WA	1770
rs183756567^1,2		--	61562479(+)	`GGGGCC/TGGGTA`	3	--	int¹		0	--	--	--	--
rs144726912^1,2	C,	--	61562490(+)	`GGACA-/GGGGCA`	3	--	int¹		0	--	--	--	--
rs17236674^1,2	C	--	61562491(+)	`CAGGG-/GCAGGG`	3	--	int¹		5		NS CSA	682
rs4320^1,2	C,F,A,H,	--	61562553(+)	`GGAGAG/AGGGAG`	3	--	int¹ trp³		18		EA NA NS WA CSA EU	2865
rs147429960^1,2	C,F	--	61562654(+)	`GACATC/GCCAGG`	6	S C	mis¹		2		NA EU	5873
rs148491967^1,2	C	--	61562724(+)	`ACCAGC/AAAGAT`	6	/R /S	mis¹		1		NA	4548
rs4321^1,2	C,F,A,H,	--	61562774(+)	`GTGCAC/G/TACACA`	3	--	int¹		13		NS WA NA CSA EA EU	2213
rs145446793^1,2		--	61562798(+)	`CCGCTC/TACCAC`	3	--	int¹		0	--	--	--	--
rs188630865^1,2		--	61562819(+)	`TGCCAC/GCACAT`	3	--	int¹		0	--	--	--	--
rs4323^1,2	C,F,	--	61562954(+)	`TAACAC/TGGTGA`	3	--	int¹		7		NA NS CSA	227
rs142534935^1,2		--	61562955(+)	`AACACA/GGTGAA`	3	--	int¹		0	--	--	--	--
rs193261194^1,2		--	61562987(+)	`CAAAAA/CTTAGC`	3	--	int¹		0	--	--	--	--
rs4324^1,2	C,F,A,H,	--	61563171(+)	`TTTTGA/GTGAAC`	3	--	int¹		22		NS EA NA WA	2460
rs4325^1,2	C,F,H,	--	61563200(+)	`CAATTC/ATTCTT`	3	--	int¹ trp³		20		NS EA NA	3304
rs4326^1,2	C,F,A,H,	--	61563242(+)	`TGGGAG/AGATCA`	3	--	int¹		10		NA NS WA EA	508
rs4327^1,2	C,F,H,	--	61563273(+)	`ACTAGC/GCTGGG`	3	--	int¹		10		NA NS WA EA	394
rs146664991^1,2		--	61563416(+)	`CCTCTA/GCAAAA`	3	--	int¹		0	--	--	--	--
rs139253966^1,2		--	61563424(+)	`AAAGGA/GGCTAC`	3	--	int¹		0	--	--	--	--
rs4329^1,2	C,F,A,H,	--	61563458(+)	`TGCCT`

Advanced Search

Export list of displayed genes

ACE Gene

angiotensin I converting enzyme (peptidyl-dipeptidase A)...

Aliases
for ACE gene

Summaries
for ACE gene

Genomic Views
for ACE gene

Proteins
for ACE gene

Protein Domains /
Families
for ACE gene

Function
for ACE gene

Pathways & Interactions
for ACE gene

Drugs & Compounds
for ACE gene

Transcripts
for ACE gene

Expression
for ACE gene

Orthologs
for ACE gene

Paralogs
for ACE gene

Genomic Variants
for ACE gene

Advanced Search

Export list of displayed genes

ACE Gene

angiotensin I converting enzyme (peptidyl-dipeptidase A)...

Aliasesfor ACE gene

Summariesfor ACE gene

Genomic Viewsfor ACE gene

Proteinsfor ACE gene

Protein Domains /Familiesfor ACE gene

Functionfor ACE gene

Pathways & Interactionsfor ACE gene

Drugs & Compoundsfor ACE gene

Transcriptsfor ACE gene

Expression for ACE gene

Orthologsfor ACE gene

Paralogsfor ACE gene

Genomic Variantsfor ACE gene

Aliases
for ACE gene

Summaries
for ACE gene

Genomic Views
for ACE gene

Proteins
for ACE gene

Protein Domains /
Families
for ACE gene

Function
for ACE gene

Pathways & Interactions
for ACE gene

Drugs & Compounds
for ACE gene

Transcripts
for ACE gene

Expression
for ACE gene

Orthologs
for ACE gene

Paralogs
for ACE gene

Genomic Variants
for ACE gene