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Aliases for ACE Gene

Aliases for ACE Gene

  • Angiotensin I Converting Enzyme 2 3
  • DCP1 3 4 6
  • Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 2 3
  • Dipeptidyl Carboxypeptidase I 3 4
  • CD143 Antigen 3 4
  • Kininase II 3 4
  • MVCD3 3 6
  • ACE1 3 6
  • ICH 3 6
  • DCP 3 4
  • Angiotensin I Converting Enzyme Peptidyl-Dipeptidase A 1 Transcript 3
  • Angiotensin Converting Enzyme, Somatic Isoform 3
  • Angiotensin-Converting Enzyme 3
  • Dipeptidyl Carboxypeptidase 1 3
  • Peptidyl-Dipeptidase A 2
  • Carboxycathepsin 3
  • Testicular ECA 3
  • Peptidase P 3
  • EC 3.4.15.1 4
  • EC 3.2.1.- 4
  • CD143 3

External Ids for ACE Gene

Previous HGNC Symbols for ACE Gene

  • DCP1

Previous GeneCards Identifiers for ACE Gene

  • GC17P061205
  • GC17P063980
  • GC17P061895
  • GC17P062027
  • GC17P058908
  • GC17P061554
  • GC17P056922

Summaries for ACE Gene

Entrez Gene Summary for ACE Gene

  • This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

GeneCards Summary for ACE Gene

ACE (Angiotensin I Converting Enzyme) is a Protein Coding gene. Diseases associated with ACE include microvascular complications of diabetes 3 and renal tubular dysgenesis, ace-related. Among its related pathways are p70S6K Signaling and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include actin binding and drug binding. An important paralog of this gene is TMEM27.

UniProtKB/Swiss-Prot for ACE Gene

  • Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety

Tocris Summary for ACE Gene

  • Angiotensin-converting enzyme (ACE, aka peptidyl dipeptidase A, carboxycathepsin) cleaves a C-terminal dipeptide from angiotensin I to create the vasoconstrictor peptide, angiotensin II. ACE can also inactivate the vasodilator peptide, bradykinin. There are two isoforms of ACE, a smaller/single catalytic site enzyme found in the testes and a more widely expressed ~180kDa dual active site isoform. ACE is often membrane bound. In contrast to ACE, the homolog ACE2, has recently been shown to cleave and inactivate angiotensin II to generate the vasodilator Angiotensin (1-7). ACE inhibitors are widely used to treat hypertension and cardiovascular diseases. ACE inhibitors have also been used to slow nephropathy, particularly when it is associated with diabetes.

Gene Wiki entry for ACE Gene

PharmGKB "VIP" Summary for ACE Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ACE Gene

Genomics for ACE Gene

Regulatory Elements for ACE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACE Gene

Start:
63,477,061 bp from pter
End:
63,498,380 bp from pter
Size:
21,320 bases
Orientation:
Plus strand

Genomic View for ACE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACE Gene

Proteins for ACE Gene

  • Protein details for ACE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12821-ACE_HUMAN
    Recommended name:
    Angiotensin-converting enzyme
    Protein Accession:
    P12821
    Secondary Accessions:
    • B0LPF0
    • B4DXI3
    • E7EU16
    • P22966
    • Q53YX9
    • Q59GY8
    • Q7M4L4

    Protein attributes for ACE Gene

    Size:
    1306 amino acids
    Molecular mass:
    149715 Da
    Cofactor:
    Name=chloride; Xref=ChEBI:CHEBI:17996; Note=Binds 3 chloride ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Isoform Testis-specific only binds 1 Zn(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Inhibitors of ACE are commonly used to treat hypertension and some types of renal and cardiac dysfunction
    • The glycosidase activity probably uses different active site residues than the metalloprotease activity
    SequenceCaution:
    • Sequence=BAD92208.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACE Gene

    Alternative splice isoforms for ACE Gene

neXtProt entry for ACE Gene

Proteomics data for ACE Gene at MOPED

Post-translational modifications for ACE Gene

  • Phosphorylated by CK2 on Ser-1299; which allows membrane retention.
  • Glycosylation at Asn38, Asn54, Asn74, Asn111, Asn146, Asn160, Asn318, Asn445, Asn509, Asn677, Asn695, Asn714, Asn760, Asn942, and Asn1191
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ACE Gene

Domains for ACE Gene

Gene Families for ACE Gene

HGNC:
  • CD :CD molecules
IUPHAR :

Protein Domains for ACE Gene

Graphical View of Domain Structure for InterPro Entry

P12821

UniProtKB/Swiss-Prot:

ACE_HUMAN :
  • P12821
Family:
  • Belongs to the peptidase M2 family.
genes like me logo Genes that share domains with ACE: view

Function for ACE Gene

Molecular function for ACE Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.51 mM for Hip-His-Leu {ECO:0000269 PubMed:11076943, ECO:0000269 PubMed:12542396};
UniProtKB/Swiss-Prot CatalyticActivity:
Release of a C-terminal dipeptide, oligopeptide- -Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly activated by chloride. Specifically inhibited by lisinopril, captopril and enalaprilat
UniProtKB/Swiss-Prot Function:
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety
UniProtKB/Swiss-Prot Induction:
Up-regulated in failing heart.

Enzyme Numbers (IUBMB) for ACE Gene

Gene Ontology (GO) - Molecular Function for ACE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 16186248
GO:0004175 endopeptidase activity IDA 15283675
GO:0004180 carboxypeptidase activity IEA --
GO:0005515 protein binding IPI 16186248
GO:0008144 drug binding IDA 1320019
genes like me logo Genes that share ontologies with ACE: view
genes like me logo Genes that share phenotypes with ACE: view

Animal Models for ACE Gene

MGI Knock Outs for ACE:

Animal Model Products

miRNA for ACE Gene

miRTarBase miRNAs that target ACE

No data available for Transcription Factor Targeting and HOMER Transcription for ACE Gene

Localization for ACE Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACE Gene

Angiotensin-converting enzyme, soluble form: Secreted.
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACE Gene COMPARTMENTS Subcellular localization image for ACE gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 4
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 2
peroxisome 2
cytosol 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ACE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 15283675
GO:0005764 lysosome IDA 11076943
GO:0005768 endosome IDA 17077303
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ACE: view

Pathways for ACE Gene

genes like me logo Genes that share pathways with ACE: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ACE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IMP 16116425
GO:0001974 blood vessel remodeling IC 1668266
GO:0002003 angiotensin maturation TAS --
GO:0002005 angiotensin catabolic process in blood IC 1668266
GO:0002019 regulation of renal output by angiotensin IC 1668266
genes like me logo Genes that share ontologies with ACE: view

Compounds for ACE Gene

Compound Products

(4) Tocris Compounds for ACE Gene

Compound Action Cas Number
Benazepril hydrochloride Angiotensin-converting enzyme (ACE) inhibitor [86541-74-4]
Moexipril hydrochloride Angiotensin-converting enzyme (ACE) inhibitor [82586-52-5]
Perindopril erbumine Angiotensin-converting enzyme (ACE) inhibitor [107133-36-8]
Ramipril Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor [87333-19-5]

(16) ApexBio Compounds for ACE Gene

Compound Action Cas Number
"Acetyl Angiotensinogen (1-14), porcine" Angiotensinogen precursor [66641-26-7]
"Angiotensin I (human, mouse, rat)" Precursor of angiotensin II [484-42-4]
Angiotensin 1/2 (1-5) Vasoconstrictor [58442-64-1]
Angiotensin 1/2 + A (2 - 8) [51833-76-2]
Benazepril HCl [86541-74-4]
Captopril ACE inhibitor [62571-86-2]
Cilazapril Monohydrate [92077-78-6]
Enalapril Maleate [76095-16-4]
Enalaprilat Dihydrate [84680-54-6]
Imidapril HCl [89396-94-1]
Lisinopril dihydrate ACE inhibitor [83915-83-7]
Moexipril HCl ACE inhibitor [82586-52-5]
Perindopril Erbumine ACE inhibitor [107133-36-8]
Quinapril HCl [82586-55-8]
Ramipril [87333-19-5]
Temocapril HCl [110221-44-8]

(5) HMDB Compounds for ACE Gene

Compound Synonyms Cas Number PubMed IDs
Angiotensin II
  • Hypertensin
11128-99-7
Bradykinin
  • Callidin I
58-82-2
Chlorine
  • Cl2
16887-00-6
Lisinopril
  • Acerbon
83915-83-7
Zinc
  • Zinc
7440-66-6

(17) Drugbank Compounds for ACE Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid
target
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
target
Benazepril
  • Benazepril HCl
86541-75-5 target inhibitor
Candoxatril
118785-03-8 target inhibitor
Captopril
  • Captoprilum [INN-Latin]
62571-86-2 target inhibitor

(1) IUPHAR Ligand for ACE Gene

Ligand Type Action Affinity Pubmed IDs
captopril Inhibitor Inhibition

(127) Novoseek inferred chemical compound relationships for ACE Gene

Compound -log(P) Hits PubMed IDs
enalapril 93.5 206
captopril 92.7 228
lisinopril 92.4 165
ramipril 91.6 161
perindopril 90.3 182
genes like me logo Genes that share compounds with ACE: view

Transcripts for ACE Gene

Unigene Clusters for ACE Gene

Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACE

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18a · 18b ^
SP1: - - - - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6:
SP7:
SP8: - -
SP9: -
SP10: -
SP11: - - -
SP12: - - - -
SP13:
SP14:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7: - - - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ACE Gene

GeneLoc Exon Structure for
ACE
ECgene alternative splicing isoforms for
ACE

Expression for ACE Gene

mRNA expression in normal human tissues for ACE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACE Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (13.4) and Lung (4.4).

Protein differential expression in normal tissues for ACE Gene

This gene is overexpressed in Urine (27.6), Pancreatic juice (18.6), and Serum (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACE Gene

SOURCE GeneReport for Unigene cluster for ACE Gene Hs.298469

mRNA Expression by UniProt/SwissProt for ACE Gene

P12821-ACE_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
genes like me logo Genes that share expressions with ACE: view

Expression partners for ACE Gene

In Situ Assay Products

Orthologs for ACE Gene

This gene was present in the common ancestor of animals.

Orthologs for ACE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACE 35
  • 87.19 (n)
  • 85.45 (a)
ACE 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC610668 35
  • 87.36 (n)
  • 85.41 (a)
-- 36
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ace 35
  • 84.48 (n)
  • 83.86 (a)
Ace 16
Ace 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ACE 35
  • 98.77 (n)
  • 98.85 (a)
rat
(Rattus norvegicus)
Mammalia Ace 35
  • 84.3 (n)
  • 84.87 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves ACE 35
  • 71.13 (n)
  • 68.62 (a)
ACE 36
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ace 35
  • 66.01 (n)
  • 66.27 (a)
Str.5776 35
zebrafish
(Danio rerio)
Actinopterygii ace 35
  • 67.1 (n)
  • 65.7 (a)
ace 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Acer 37
  • 40 (a)
Ance 37
  • 44 (a)
Ance-2 37
  • 26 (a)
Ance-3 37
  • 39 (a)
Ance-4 37
  • 26 (a)
Ance-5 37
  • 27 (a)
Acer 36
  • 40 (a)
ManyToMany
Ance 36
  • 44 (a)
ManyToMany
Ance-3 36
  • 35 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ANCE9 35
  • 51.26 (n)
  • 42.68 (a)
worm
(Caenorhabditis elegans)
Secernentea acn-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for ACE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACE Gene

ENSEMBL:
Gene Tree for ACE (if available)
TreeFam:
Gene Tree for ACE (if available)

Paralogs for ACE Gene

Paralogs for ACE Gene

genes like me logo Genes that share paralogs with ACE: view

Variants for ACE Gene

Sequence variations from dbSNP and Humsavar for ACE Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4291 -- 63,476,833(+) TCTTC(A/T)AAAGA upstream-variant-2KB
rs4292 -- 63,476,980(+) GGACT(C/T)TGGAG upstream-variant-2KB
rs4293 -- 63,478,305(+) AGGAA(A/G)CATTC intron-variant
rs4294 -- 63,478,663(+) CCCCC(A/C)AAAAA intron-variant
rs4295 -- 63,478,937(-) TGCTA(C/G)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACE Gene

Variant ID Type Subtype PubMed ID
nsv908682 CNV Loss 21882294
nsv908683 CNV Loss 21882294
nsv525599 CNV Loss 19592680
esv270563 CNV Insertion 20981092
esv273813 CNV Insertion 20981092
nsv817771 CNV Loss 17921354

Relevant External Links for ACE Gene

HapMap Linkage Disequilibrium report
ACE
Human Gene Mutation Database (HGMD)
ACE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACE Gene

Disorders for ACE Gene

(4) OMIM Diseases for ACE Gene (106180)

UniProtKB/Swiss-Prot

ACE_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:15534175}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Microvascular complications of diabetes 3 (MVCD3) [MIM:612624]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Intracerebral hemorrhage (ICH) [MIM:614519]: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. {ECO:0000269 PubMed:15277638}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for ACE Gene

Disease -log(P) Hits PubMed IDs
heart failure 90.4 346
diabetic nephropathies 86.7 235
essential hypertension 86.5 179
heart failure congestive 86.2 157
renal disease 85.5 262

Relevant External Links for ACE

Genetic Association Database (GAD)
ACE
Human Genome Epidemiology (HuGE) Navigator
ACE
genes like me logo Genes that share disorders with ACE: view

No data available for Genatlas for ACE Gene

Publications for ACE Gene

  1. Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme. (PMID: 15236580) Natesh R. … Acharya K.R. (Biochemistry 2004) 3 4 23 25
  2. Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes. (PMID: 1649623) Ehlers M.R.W. … Riordan J.F. (Biochemistry 1991) 3 4 23
  3. Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction. (PMID: 8541160) Arbustini E. … Specchia G. (Br Heart J 1995) 3 23 48
  4. Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites. (PMID: 10769174) Woodman Z.L. … Sturrock E.D. (Biochem. J. 2000) 3 4 23
  5. The relationship of angiotensin-converting enzyme gene to essential hypertension and drug treatment in Chongqing. (PMID: 11024215) Liu Q. … Wang X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000) 3 23 48

Products for ACE Gene

Sources for ACE Gene

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