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ACD Gene

protein-coding   GIFtS: 53
GCID: GC16M067691

Adrenocortical Dysplasia Homolog (Mouse)

  See ACD-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenocortical Dysplasia Homolog (Mouse)1 2     TIN2 Interacting Protein 11 2
PIP12 3 5     TPP12 3
PTOP2 3 5     POT1 And TIN2-Interacting Protein2 3
TINT12 3 5     Adrenocortical Dysplasia Protein Homolog2
POT1 And TIN2 Organizing Protein1 2     

External Ids:    HGNC: 250701   Entrez Gene: 650572   Ensembl: ENSG000001029777   OMIM: 6093775   UniProtKB: Q96AP03   

Export aliases for ACD gene to outside databases

Previous GC identifers: GC16M066249 GC16M053564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACD Gene:
This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the
telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends.
Through its interaction with other components, this protein plays a key role in the assembly and stabilization of
this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding
different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from
the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACD Gene:
ACD (adrenocortical dysplasia homolog (mouse)) is a protein-coding gene. Diseases associated with ACD include breast cancer susceptibility. GO annotations related to this gene include DNA polymerase binding and telomeric DNA binding.

UniProtKB/Swiss-Prot: ACD_HUMAN, Q96AP0
Function: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and
protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects
chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance
and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to
single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1
heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex
assembly. May play a role in organogenesis

Gene Wiki entry for ACD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACD gene promoter:
         AREB6   Pax-5   AML1a   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACD promoter sequence
   Search Chromatin IP Primers for ACD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

ACD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACD gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067691:  view genomic region     (about GC identifiers)

Start:
67,691,415 bp from pter      End:
67,694,718 bp from pter
Size:
3,304 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ACD_HUMAN, Q96AP0 (See protein sequence)
Recommended Name: Adrenocortical dysplasia protein homolog  
Size: 544 amino acids; 57733 Da
Subunit: Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1.
Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with
STN1/OBFC1 and TINF2
Sequence caution: Sequence=AAX82621.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ACD:
2I46 (3D)    
Secondary accessions: Q562H5 Q9H8F9
Alternative splicing: 2 isoforms:  Q96AP0-1   Q96AP0-2   

Explore the universe of human proteins at neXtProt for ACD: NX_Q96AP0

Explore proteomics data for ACD at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys492
  • Modification sites at PhosphoSitePlus

  • See ACD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001075955.1  NP_001075956.1  NP_075065.2  

    ENSEMBL proteins: 
     ENSP00000219251   ENSP00000473313   ENSP00000377496   ENSP00000473679   ENSP00000473595  
    Reactome Protein details: Q96AP0

    ACD Human Recombinant Protein Products:

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    Novus Biologicals ACD Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACD

     
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    antibodies-online proteins for ACD (4 products) 

     
    antibodies-online peptides for ACD

    ACD Antibody Products:

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    antibodies-online antibodies for ACD (59 products) 

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    antibodies-online kits for ACD (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028631 ACD

    Graphical View of Domain Structure for InterPro Entry Q96AP0

    ProtoNet protein and cluster: Q96AP0


    Find genes that share domains with ACD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACD_HUMAN, Q96AP0
    Function: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and
    protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects
    chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance
    and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to
    single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1
    heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex
    assembly. May play a role in organogenesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI15231715
    GO:0042162telomeric DNA binding ----
    GO:0070182DNA polymerase binding IPI17237767
         
    Find genes that share ontologies with ACD           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Acd):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail 
     mortality/aging  pigmentation  renal/urinary system  reproductive system  tumorigenesis 

    Find genes that share phenotypes with ACD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Acdtm1.2Cek for ACD

       genOway: Develop your customized and physiologically relevant rodent model for ACD

    miRNA
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    miRTarBase miRNAs that target ACD:
    hsa-mir-24-3p (MIRT030394)

    Block miRNA regulation of human, mouse, rat ACD using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ACD:
    hsa-miR-548am hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidACD 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript Custom all cDNA clones Services for ACD
    Sino Biological Human cDNA Clone for ACD
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACD
    Addgene plasmids for ACD 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACD_HUMAN, Q96AP0: Nucleus. Chromosome, telomere
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IDA15380063
    GO:0000783nuclear telomere cap complex IDA16880378
    GO:0005654nucleoplasm TAS--
    GO:0005697telomerase holoenzyme complex ----

    Find genes that share ontologies with ACD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACD About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Telomere Maintenance0.64
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    DNA Damage/Telomere Stress Induced Senescence0.65
    2Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    3Cell Cycle, Mitotic
    Cell Cycle0.90
    4Meiosis (REACTOME)
    Meiosis0.74
    5Regulation of Telomerase
    Regulation of Telomerase


    Find genes that share SuperPaths with ACD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ACD
        Regulation of Telomerase


    3 Reactome Pathways for ACD
        Packaging Of Telomere Ends
    Meiotic synapsis
    DNA Damage/Telomere Stress Induced Senescence


        Pathway & Disease-focused RT2 Profiler PCR Array including ACD: 
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ACD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACD (Q96AP01, 2, 3 ENSP000003774964) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF1Q929001, 2, 3, ENSP000002628034EBI-717666,EBI-373471 MINT-8286631 MINT-8286600 MINT-8286615 I2D: score=1 STRING: ENSP00000262803
    XRCC6P129562, 3MINT-65113 I2D: score=5 
    C6orf48Q9UBA63I2D: score=1 
    ENSG00000206380Q9UBA63I2D: score=1 
    ENSG00000226710Q9UBA63I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance TAS--
    GO:0001501skeletal system development IEA--
    GO:0001655urogenital system development IEA--
    GO:0006886intracellular protein transport IMP15181449
    GO:0007004telomere maintenance via telomerase ----

    Find genes that share ontologies with ACD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACD

    1 Novoseek inferred chemical compound relationship for ACD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tin(2+) 98.1 13 15316005 (3), 15380063 (3), 15383534 (3), 15231715 (2) (see all 6)



    Find genes that share compounds with ACD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACD gene (3 alternative transcripts): 
    NM_001082486.1  NM_001082487.1  NM_022914.2  

    Unigene Cluster for ACD:

    Adrenocortical dysplasia homolog (mouse)
    Hs.78019  [show with all ESTs]
    Unigene Representative Sequence: NM_001082486
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219251(uc002etp.4 uc002etq.4 uc002etr.4 uc010vjt.1)
    ENST00000602382 ENST00000393919 ENST00000602656 ENST00000602622 ENST00000602320
    ENST00000602860 ENST00000602850 ENST00000602945 ENST00000602519 ENST00000602423
    ENST00000602780 ENST00000602821
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ACD:
    hsa-miR-548am hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidACD 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ACD
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACD
      QuantiTect SYBR Green Assays in human, mouse, rat ACD
      QuantiFast Probe-based Assays in human, mouse, rat ACD

    Additional mRNA sequence: 

    AF070535.1 AK023726.1 AK301090.1 AY502940.1 BC016904.1 

    13 DOTS entries:

    DT.312917  DT.95161809  DT.100016955  DT.95161808  DT.75126055  DT.100817189  DT.427457  DT.100817181 
    DT.120660503  DT.95161806  DT.100817182  DT.92436100  DT.97852587 

    Selected AceView cDNA sequences (see all 221):

    CB131102 BX091130 BM479322 AA766528 BI756687 BI752954 CR605529 BQ917922 
    CR609290 CB989933 CR603519 BE393922 CR615919 AK125623 BQ687392 CR592709 
    BM127444 BI832604 BQ673954 BI755782 BG910289 CA489036 AI274041 CR599071 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACD (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^
    SP1:                                                                          -                 -           -     -     -                                       
    SP2:                                                        -                 -                 -           -     -     -                                       
    SP3:                                                                                            -           -     -     -                                       
    SP4:                                                                          -                 -           -     -     -                                       
    SP5:                                                                          -                 -                                                               

    ExUns: 10a · 10b ^ 11 ^ 12
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ACD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCAAAAAA
    ACD Expression
    About this image

    ACD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78019
        Pathway & Disease-focused RT2 Profiler PCR Array including ACD: 
              Telomeres & Telomerase in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ACD gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acd1 , 5 adrenocortical dysplasia1, 5 76(n)1
    64.63(a)1
      8 (53.04 cM)5
    4976521  NM_001012638.11  NP_001012656.11 
     1056981595 
    chicken
    (Gallus gallus)
    Aves ACD6
    adrenocortical dysplasia homolog (mouse)
    21(a)
    1 ↔ 1
    11(1149085-1154559)


    ENSEMBL Gene Tree for ACD (if available)
    TreeFam Gene Tree for ACD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACD gene

    Find genes that share paralogs with ACD           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ACD
    PGOHUM00000238369 PGOHUM00000245719


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACD (see all 52)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002271161,2
    --67692039(+) ACATGA/GCTACG 6 S syn10--------
    rs2021047411,2
    C--67692098(+) GCTGGC/TGTGTG 6 T A mis10--------
    rs1473068631,2
    C--67692151(+) GTGAGG/TGCTGG 6 H P mis11Minor allele frequency- T:0.00NA 4514
    rs1471891921,2
    C,F--67692172(+) TCTGCC/TCTGGG 6 E G mis12Minor allele frequency- T:0.01NA EU 5699
    rs2002983081,2
    --67692233(+) TTCCTC/TGGATG 6 K E mis10--------
    rs1998569651,2
    --67692249(+) TGGCCA/GGGTAA 6 P syn10--------
    rs2019654771,2
    C--67692258(+) AAGGCC/TGGGGT 6 P syn10--------
    rs725491801,2
    F--67692373(-) TGCACG/AGTGGG 3 -- int16Minor allele frequency- A:0.02MN WA 526
    rs1827656271,2
    --67692397(+) CCTGCA/GCAGCC 3 -- int10--------
    rs1387408151,2
    C,F--67692468(+) GAACTG/AGGTGA 6 /P syn11Minor allele frequency- A:0.00NA 4516

    HapMap Linkage Disequilibrium report for ACD (67691415 - 67694718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ACD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906809CNV Loss21882294
    dgv2890n71CNV Loss21882294
    dgv2891n71CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACD
    DNA2.0 Custom Variant and Variant Library Synthesis for ACD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609377    OMIM disorders: --

    1 disease for ACD:    
    About MalaCards
    breast cancer susceptibility


    Find genes that share disorders with ACD           About GenesLikeMe

    Genetic Association Database (GAD): ACD
    Human Genome Epidemiology (HuGE) Navigator: ACD (14 documents)

    Export disorders for ACD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACD gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with ACD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PTOP interacts with POT1 and regulates its localization to telomeres. (PubMed id 15181449)1, 2, 3, 9 Liu D....Songyang Z. (Nat. Cell Biol. 2004)
    2. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. (PubMed id 15231715)1, 2, 3, 9 Ye J.Z.-S.... de Lange T. (Genes Dev. 2004)
    3. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. (PubMed id 15316005)1, 2, 9 Ye J.Z.-S.... de Lange T. (J. Biol. Chem. 2004)
    4. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. (PubMed id 15383534)1, 2, 9 Liu D.... Songyang Z. (J. Biol. Chem. 2004)
    5. Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study. (PubMed id 20937264)1, 4 Zee R.Y....Chasman D.I. ( international journal of clinical chemistry 2011)
    6. OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. (PubMed id 19648609)1, 2 Wan M.... Liu D. (J. Biol. Chem. 2009)
    7. Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis. (PubMed id 19766477)1, 4 Varadi V....FAPrsti A. (Eur. J. Cancer 2009)
    8. The POT1-TPP1 telomere complex is a telomerase processivity factor. (PubMed id 17237768)1, 2 Wang F.... Lei M. (Nature 2007)
    9. Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromes. (PubMed id 17466001)1, 4 Keegan C.E....Hammer G.D. (Clin. Endocrinol. (Oxf) 2007)
    10. A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. (PubMed id 16880378)1, 2 O'Connor M.S.... Songyang Z. (Proc. Natl. Acad. Sci. U.S.A. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65057 HGNC: 25070 AceView: PTOP Ensembl:ENSG00000102977 euGenes: HUgn65057
    ECgene: ACD H-InvDB: ACD

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ACD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ACD gene:
    Search GeneIP for patents involving ACD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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