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ACCSL Gene

protein-coding   GIFtS: 36
GCID: GC11P044027

1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
1-Aminocyclopropane-1-Carboxylate Synthase Homolog
(Arabidopsis)(Non-Functional)-Like1 2
ACC Synthase-Like Protein 22 3
1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 22
Probable Inactive 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein
22

External Ids:    HGNC: 343911   Entrez Gene: 3901102   Ensembl: ENSG000002051267   UniProtKB: Q4AC993   

Export aliases for ACCSL gene to outside databases

Previous GC identifer: GC11P043778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ACCSL Gene:
ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like) is a protein-coding gene. GO annotations related to this gene include pyridoxal phosphate binding. An important paralog of this gene is ACCS.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACCSL gene promoter:
         STAT1   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   Ik-2   HOXA5   STAT2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACCSL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ACCSL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACCSL gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044027:  view genomic region     (about GC identifiers)

Start:
44,069,531 bp from pter      End:
44,081,527 bp from pter
Size:
11,997 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: 1A1L2_HUMAN, Q4AC99 (See protein sequence)
Recommended Name: Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2  
Size: 568 amino acids; 65249 Da
Caution: While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number
of residues which are necessary for activity thus suggesting that it lacks enzymatic activity

Explore the universe of human proteins at neXtProt for ACCSL: NX_Q4AC99

Explore proteomics data for ACCSL at MOPED


See ACCSL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001027025.2  
ENSEMBL proteins: 
 ENSP00000368109   ENSP00000436505  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR015422 PyrdxlP-dep_Trfase_major_sub2
 IPR004839 Aminotransferase_I/II
 IPR015424 PyrdxlP-dep_Trfase
 IPR015421 PyrdxlP-dep_Trfase_major_sub1

Graphical View of Domain Structure for InterPro Entry Q4AC99

ProtoNet protein and cluster: Q4AC99

UniProtKB/Swiss-Prot: 1A1L2_HUMAN, Q4AC99
Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


Find genes that share domains with ACCSL           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity IEA--
GO:0030170pyridoxal phosphate binding IEA--
     
Find genes that share ontologies with ACCSL           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
endoplasmic reticulum1
mitochondrion1
nucleus1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACCSL
Interactions:

    Search GeneGlobe Interaction Network for ACCSL

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ACCSL (ENSP000003681094) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
THNSL1ENSP000003655344STRING: ENSP00000365534
THNSL2ENSP000003273234STRING: ENSP00000327323
AGXTENSP000003026204STRING: ENSP00000302620
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0009058biosynthetic process IEA--

Find genes that share ontologies with ACCSL           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ACCSL (1A1L2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ACCSL gene: 
NM_001031854.2  

Unigene Cluster for ACCSL:

1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like
Hs.558851  [show with all ESTs]
Unigene Representative Sequence: NM_001031854
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000378832(uc001mxw.1 uc009ykr.2) ENST00000527145
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Additional mRNA sequence: 

AB231732.1 AB231733.1 AB231734.1 BC144554.1 

1 DOTS entry:

DT.120683219 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ACCSL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGATCTGGGG
ACCSL Expression
About this image


ACCSL expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Neurons
         nGnG Amacrine Cells Inner Nuclear Layer
 
 Inner Cell Mass (Early Embryonic Tissues)
         Blimp1- mVenus and stella-ECFP genetically modified stem cells
 
 Eye (Sensory Organs)
         nGnG Amacrine Cells Inner Nuclear Layer
 
 Ovary (Reproductive System)
ACCSL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ACCSL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.558851
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for ACCSL gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Accsl1 , 5 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like less5
1-aminocyclopropane-1-carboxylate synthase (non-functional)-like less1
70.86(n)1
59.24(a)1
  2 (51.62 cM)5
3814111  NM_001033452.41  NP_001028624.21 
 938553615 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
46(a)
1 → many
5(21006095-21019310) ENSGALG00000007997
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
49(a)
1 → many
1(45535229-45561979)
zebrafish
(Danio rerio)
Actinopterygii accs6
1-aminocyclopropane-1-carboxylate synthase homolog...
24(a)
1 → many
25(9149694-9177908) ENSDARG00000052124
worm
(Caenorhabditis elegans)
Secernentea T04F3.16
Protein T04F3.1, isoform a (T04F3.1) mRNA, complet...
4(a)
1 → many
V(11740230-11754199) WBGene00011436
thale cress
(Arabidopsis thaliana)
eudicotyledons ACS21 ACS2 45.59(n)
33.33(a)
  837082  NM_100030.3  NP_171655.1 
rice
(Oryza sativa)
Liliopsida Os04g05780001 Os04g0578000 46.25(n)
31.72(a)
  4336750  NM_001060172.1  NP_001053637.1 


ENSEMBL Gene Tree for ACCSL (if available)
TreeFam Gene Tree for ACCSL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ACCSL gene
ACCS2  
1 SIMAP similar gene for ACCSL using alignment to 2 protein entries:     1A1L2_HUMAN (see all proteins):
ACCS

Find genes that share paralogs with ACCSL           About GenesLikeMe


1 Pseudogenes.org Pseudogene for ACCSL
PGOHUM00000243055


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ACCSL (see all 362)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1461496361,2
--44067538(+) CACTCC/TGCAGG 1 -- us2k10--------
rs790913281,2
F--44067619(+) CTCTAT/CGATAA 1 -- us2k11Minor allele frequency- C:0.01NA 120
rs1835114171,2
--44067740(+) AGAGAC/TGGTTT 1 -- us2k10--------
rs1162070851,2
F--44067840(+) TTGGGA/TTCGTA 1 -- us2k11Minor allele frequency- T:0.08WA 118
rs1885041681,2
--44067970(+) TGCCTC/TTCCTA 1 -- us2k10--------
rs1401975011,2
--44068107(+) AATGGA/GAACAT 1 -- us2k10--------
rs1929108761,2
--44068206(+) CGAGGC/TTTTTT 1 -- us2k10--------
rs1439266291,2
--44068213(+) TTTTTG/TTGTGT 1 -- us2k10--------
rs1390904821,2
C--44068239(+) GGATG-/TTTACT 1 -- us2k10--------
rs1404519431,2
--44068510(+) TGCAGG/TAAGCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ACCSL (44069531 - 44081527 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ACCSL:    About this table    
Variant IDTypeSubtypePubMed ID
nsv510251CNV Loss20534489

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ACCSL
DNA2.0 Custom Variant and Variant Library Synthesis for ACCSL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ACCSL gene integrated from 10 sources:
(articles sorted by number of sources associating them with ACCSL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 390110 HGNC: 34391 Ensembl:ENSG00000205126 euGenes: HUgn390110 ECgene: ACCSL
H-InvDB: ACCSL

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ACCSL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ACCSL gene:
Search GeneIP for patents involving ACCSL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACCSL
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 LSBio Antibodies in human, mouse, rat for ACCSL
 Browse compounds at ApexBio
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Customized transgenic rodents for:
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 antibodies-online antibodies for ACCSL (17 products)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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